drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00741 | DB10343 | 167 | 962 | [
"DDInter885",
"DDInter160"
] | Hydrocortisone | Bacillus calmette-guerin substrain tice live antigen | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
167,
25,
962
]
],
[
[
167,
1,
617
],
[
617,
24,
962
]
],
[
[
167,
64,
1057
],
[
1057,
25,
962
]
],
[
[
167,
24,
1213
],
[
1213,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Budesonide"
],
[
"Budesoni... | Hydrocortisone (Compound) resembles Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Bacillus calmette-guerin substrain tice live antigen
Hydrocortisone may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead... |
DB01210 | DB09135 | 668 | 1,211 | [
"DDInter1050",
"DDInter967"
] | Levobunolol (ophthalmic) | Ioxilan | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
668,
24,
1211
]
],
[
[
668,
40,
887
],
[
887,
24,
1211
]
],
[
[
668,
24,
1013
],
[
1013,
63,
1211
]
],
[
[
668,
24,
512
],
[
512,
... | [
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Levobunolol",
"{u} (Compound) resembles {v} (Compound)",
"Pindolol"
],
[
"Pindolol",
"{u} may cause a moderate int... | Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Levobunolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Levobunolol may cause a moderate interaction that could exacerbate... |
DB00095 | DB01284 | 66 | 1,042 | [
"DDInter623",
"DDInter1782"
] | Efalizumab | Tetracosactide | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
66,
24,
1042
]
],
[
[
66,
24,
1683
],
[
1683,
63,
1042
]
],
[
[
66,
25,
1137
],
[
1137,
63,
1042
]
],
[
[
66,
63,
1184
],
[
1184,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Efalizumab may lead to a major life threatening interaction when taken with Measles virus vaccine live att... |
DB00593 | DB01075 | 1,464 | 1,376 | [
"DDInter695",
"DDInter569"
] | Ethosuximide | Diphenhydramine | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1464,
24,
1376
]
],
[
[
1464,
24,
649
],
[
649,
63,
1376
]
],
[
[
1464,
63,
128
],
[
128,
24,
1376
]
],
[
[
1464,
24,
832
],
[
832,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheni... |
DB01281 | DB14409 | 881 | 1,129 | [
"DDInter5",
"DDInter867"
] | Abatacept | Human adenovirus e serotype 4 strain cl-68578 antigen | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
881,
24,
1129
]
],
[
[
881,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
881,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
881,
63,
1184
],
[
1184,
... | [
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Abatacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"E... | Abatacept may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Abatacept may cause a moderate interaction that could exacerbate diseases when taken ... |
DB11652 | DB12130 | 1,155 | 1,017 | [
"DDInter1891",
"DDInter1094"
] | Tucatinib | Lorlatinib | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
1155,
25,
1017
]
],
[
[
1155,
63,
608
],
[
608,
23,
1017
]
],
[
[
1155,
62,
1101
],
[
1101,
23,
1017
]
],
[
[
1155,
64,
175
],
[
175,
... | [
[
[
"Tucatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Tucatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",
... | Tucatinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Tucatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may... |
DB00543 | DB00835 | 87 | 100 | [
"DDInter82",
"DDInter245"
] | Amoxapine | Brompheniramine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
87,
24,
100
]
],
[
[
87,
24,
832
],
[
832,
24,
100
]
],
[
[
87,
63,
128
],
[
128,
24,
100
]
],
[
[
87,
24,
649
],
[
649,
63,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphe... |
DB00620 | DB09268 | 175 | 1,662 | [
"DDInter1855",
"DDInter1464"
] | Triamcinolone | Picosulfuric acid | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
175,
24,
1662
]
],
[
[
175,
24,
1482
],
[
1482,
23,
1662
]
],
[
[
175,
63,
1252
],
[
1252,
23,
1662
]
],
[
[
175,
24,
1619
],
[
1619,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and ... |
DB00014 | DB12141 | 521 | 971 | [
"DDInter839",
"DDInter817"
] | Goserelin | Gilteritinib | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
521,
24,
971
]
],
[
[
521,
23,
1247
],
[
1247,
23,
971
]
],
[
[
521,
24,
485
],
[
485,
24,
971
]
],
[
[
521,
24,
730
],
[
730,
6... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB00353 | DB09098 | 588 | 98 | [
"DDInter1187",
"DDInter1700"
] | Methylergometrine | Somatrem | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
588,
24,
98
]
],
[
[
588,
24,
159
],
[
159,
63,
98
]
],
[
[
588,
25,
609
],
[
609,
24,
98
]
],
[
[
588,
24,
868
],
[
868,
24,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Methylergometrine may lead to a major life threatening interaction when taken with Clarithromycin and... |
DB00656 | DB12500 | 827 | 283 | [
"DDInter1851",
"DDInter714"
] | Trazodone | Fedratinib | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
827,
24,
283
]
],
[
[
827,
24,
351
],
[
351,
23,
283
]
],
[
[
827,
25,
1593
],
[
1593,
23,
283
]
],
[
[
827,
63,
1419
],
[
1419,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Trazodone may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a mi... |
DB01024 | DB09278 | 1,096 | 852 | [
"DDInter1252",
"DDInter24"
] | Mycophenolic acid | Activated charcoal | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Major | 2 | [
[
[
1096,
25,
852
]
],
[
[
1096,
62,
157
],
[
157,
24,
852
]
],
[
[
1096,
63,
964
],
[
964,
24,
852
]
],
[
[
1096,
25,
1377
],
[
1377,
... | [
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Activated charcoal"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ethotoin"
],
[... | Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ethotoin and Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Doxyc... |
DB01024 | DB06590 | 1,096 | 1,682 | [
"DDInter1252",
"DDInter329"
] | Mycophenolic acid | Ceftaroline fosamil | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia. | Moderate | 1 | [
[
[
1096,
24,
1682
]
],
[
[
1096,
24,
1462
],
[
1462,
1,
1682
]
],
[
[
1096,
63,
149
],
[
149,
40,
1682
]
],
[
[
1096,
63,
778
],
[
778,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftaroline fosamil"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefd... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Ceftaroline fosamil (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembl... |
DB00912 | DB12010 | 473 | 214 | [
"DDInter1581",
"DDInter785"
] | Repaglinide | Fostamatinib | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
473,
24,
214
]
],
[
[
473,
63,
723
],
[
723,
24,
214
]
],
[
[
473,
24,
861
],
[
861,
63,
214
]
],
[
[
473,
24,
879
],
[
879,
24,... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib and Ri... |
DB01246 | DB01367 | 820 | 1,163 | [
"DDInter45",
"DDInter1572"
] | Alimemazine | Rasagiline | A phenothiazine derivative that is used as an antipruritic. | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
820,
24,
1163
]
],
[
[
820,
21,
30438
],
[
30438,
60,
1163
]
],
[
[
820,
63,
100
],
[
100,
24,
1163
]
],
[
[
820,
25,
985
],
[
985,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Alimemazine",
"{u} (Compound) causes {v} (Side Effect)",
"Muscle rigidity"
],
[
"Muscle rigidity",
"{u} (Side E... | Alimemazine (Compound) causes Muscle rigidity (Side Effect) and Muscle rigidity (Side Effect) is caused by Rasagiline (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases... |
DB09570 | DB10316 | 1,480 | 334 | [
"DDInter1002",
"DDInter1248"
] | Ixazomib | Mumps virus strain B level jeryl lynn live antigen | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1480,
25,
334
]
],
[
[
1480,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1480,
63,
310
],
[
310,
25,
334
]
],
[
[
1480,
25,
1259
],
[
1259,
... | [
[
[
"Ixazomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Ixazomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
],
... | Ixazomib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and... |
DB00371 | DB00692 | 1,050 | 274 | [
"DDInter1154",
"DDInter1448"
] | Meprobamate | Phentolamine | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
1050,
24,
274
]
],
[
[
1050,
21,
29118
],
[
29118,
60,
274
]
],
[
[
1050,
24,
530
],
[
530,
24,
274
]
],
[
[
1050,
24,
104
],
[
104,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Meprobamate",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect)... | Meprobamate (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00370 | DB00398 | 1,251 | 79 | [
"DDInter1230",
"DDInter1702"
] | Mirtazapine | Sorafenib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
1251,
24,
79
]
],
[
[
1251,
6,
6017
],
[
6017,
45,
79
]
],
[
[
1251,
7,
5727
],
[
5727,
46,
79
]
],
[
[
1251,
18,
10699
],
[
10699,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Mirtazapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sorafenib (Compound)
Mirtazapine (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Sorafenib (Compound)
Mirtazapine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Sorafenib (Compound)
Mirtazapine (C... |
DB01006 | DB04865 | 300 | 4 | [
"DDInter1040",
"DDInter1335"
] | Letrozole | Omacetaxine mepesuccinate | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
300,
24,
4
]
],
[
[
300,
7,
2384
],
[
2384,
46,
4
]
],
[
[
300,
25,
770
],
[
770,
24,
4
]
],
[
[
300,
24,
1619
],
[
1619,
63,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Letrozole",
"{u} (Compound) upregulates {v} (Gene)",
"CDK6"
],
[
"CDK6",
"{u} (Gene) is upregulate... | Letrozole (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Letrozole may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesucci... |
DB00295 | DB00889 | 475 | 1,133 | [
"DDInter1244",
"DDInter840"
] | Morphine | Granisetron | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
475,
24,
1133
]
],
[
[
475,
24,
19
],
[
19,
40,
1133
]
],
[
[
475,
24,
85
],
[
85,
1,
1133
]
],
[
[
475,
6,
8374
],
[
8374,
45,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Compound)
Morp... |
DB00346 | DB01254 | 472 | 1,213 | [
"DDInter44",
"DDInter484"
] | Alfuzosin | Dasatinib | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
472,
24,
1213
]
],
[
[
472,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
472,
18,
2852
],
[
2852,
57,
1213
]
],
[
[
472,
21,
28743
],
[
28743,... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Alfuzosin (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Dasatinib (Compound)
Alfuzosin (Compound) causes Atrial fibrillation (Side Effect) and Atrial fibrillation (Side Effect) is caused by Dasatinib... |
DB00701 | DB01390 | 1,091 | 1,117 | [
"DDInter90",
"DDInter1683"
] | Amprenavir | Sodium bicarbonate | Amprenavir is a protease inhibitor used to treat HIV infection. | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
1091,
24,
1117
]
],
[
[
1091,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
1091,
24,
1220
],
[
1220,
23,
1117
]
],
[
[
1091,
63,
1573
],
[
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Amprenavir",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is ... | Amprenavir (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with... |
DB00405 | DB06204 | 128 | 768 | [
"DDInter517",
"DDInter1746"
] | Dexbrompheniramine | Tapentadol | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Moderate | 1 | [
[
[
128,
24,
768
]
],
[
[
128,
24,
1123
],
[
1123,
24,
768
]
],
[
[
128,
63,
999
],
[
999,
24,
768
]
],
[
[
128,
24,
849
],
[
849,
6... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tapentadol"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheli... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01599 | DB06595 | 1,232 | 1,491 | [
"DDInter1523",
"DDInter1214"
] | Probucol | Midostaurin | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1232,
24,
1491
]
],
[
[
1232,
62,
112
],
[
112,
23,
1491
]
],
[
[
1232,
63,
888
],
[
888,
24,
1491
]
],
[
[
1232,
24,
657
],
[
657,
... | [
[
[
"Probucol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Probucol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxife... |
DB01041 | DB01219 | 770 | 716 | [
"DDInter1789",
"DDInter473"
] | Thalidomide | Dantrolene | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Moderate | 1 | [
[
[
770,
24,
716
]
],
[
[
770,
21,
28698
],
[
28698,
60,
716
]
],
[
[
770,
24,
1609
],
[
1609,
63,
716
]
],
[
[
770,
63,
100
],
[
100,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dantrolene"
]
],
[
[
"Thalidomide",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caus... | Thalidomide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dantrolene (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with D... |
DB00590 | DB01168 | 1,433 | 1,053 | [
"DDInter592",
"DDInter1526"
] | Doxazosin | Procarbazine | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1433,
24,
1053
]
],
[
[
1433,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1433,
24,
104
],
[
104,
24,
1053
]
],
[
[
1433,
63,
1648
],
[
16... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Doxazosin",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused... | Doxazosin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Proca... |
DB00065 | DB00620 | 581 | 175 | [
"DDInter923",
"DDInter1855"
] | Infliximab | Triamcinolone | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Major | 2 | [
[
[
581,
25,
175
]
],
[
[
581,
25,
1573
],
[
1573,
1,
175
]
],
[
[
581,
25,
617
],
[
617,
40,
175
]
],
[
[
581,
24,
1072
],
[
1072,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Prednisone",
"{u... | Infliximab may lead to a major life threatening interaction when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Infliximab may lead to a major life threatening interaction when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compound)
Infliximab may cause a m... |
DB01001 | DB09564 | 688 | 1,296 | [
"DDInter1632",
"DDInter930"
] | Salbutamol | Insulin degludec | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
688,
24,
1296
]
],
[
[
688,
64,
17
],
[
17,
24,
1296
]
],
[
[
688,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
688,
63,
1645
],
[
1645,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Salbutamol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotalol... | Salbutamol may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may caus... |
DB01263 | DB04868 | 859 | 478 | [
"DDInter1494",
"DDInter1293"
] | Posaconazole | Nilotinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
859,
25,
478
]
],
[
[
859,
25,
1468
],
[
1468,
63,
478
]
],
[
[
859,
6,
4973
],
[
4973,
45,
478
]
],
[
[
859,
21,
28963
],
[
28963,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} ... | Posaconazole may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Posaconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Posaconazole (Compound) causes Anxi... |
DB00580 | DB00775 | 311 | 1,226 | [
"DDInter1910",
"DDInter1818"
] | Valdecoxib | Tirofiban | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Moderate | 1 | [
[
[
311,
24,
1226
]
],
[
[
311,
24,
714
],
[
714,
63,
1226
]
],
[
[
311,
63,
1061
],
[
1061,
24,
1226
]
],
[
[
311,
24,
1512
],
[
1512,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tirofiban"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Tirofiban
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprosti... |
DB00214 | DB01097 | 1,028 | 1,377 | [
"DDInter1836",
"DDInter1033"
] | Torasemide | Leflunomide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Moderate | 1 | [
[
[
1028,
24,
1377
]
],
[
[
1028,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
1028,
21,
28864
],
[
28864,
60,
1377
]
],
[
[
1028,
24,
126
],
[
12... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leflunomide"
]
],
[
[
"Torasemide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Torasemide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Torasemide (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Leflunomide (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB06589 | DB10583 | 1,250 | 949 | [
"DDInter1400",
"DDInter415"
] | Pazopanib | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1250,
24,
949
]
],
[
[
1250,
64,
1377
],
[
1377,
24,
949
]
],
[
[
1250,
63,
58
],
[
58,
24,
949
]
],
[
[
1250,
25,
1259
],
[
1259,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Pazopanib may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Pazopanib may cause a moderate interaction that could exacerbate diseases wh... |
DB08881 | DB13874 | 868 | 1,501 | [
"DDInter1925",
"DDInter639"
] | Vemurafenib | Enasidenib | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
868,
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[
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663,
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[
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[
[
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[
1180,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Vemurafenib may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may ca... |
DB00703 | DB09020 | 997 | 28 | [
"DDInter1167",
"DDInter212"
] | Methazolamide | Bisacodyl | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
997,
24,
28
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],
[
[
997,
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],
[
6929,
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[
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997,
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28809
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[
28809,
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]
],
[
[
997,
63,
870
],
[
870,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Methazolamide",
"{u} (Compound) downregulates {v} (Gene)",
"ITGAE"
],
[
"ITGAE",
"{u} (Gene) is downregulated ... | Methazolamide (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Bisacodyl (Compound)
Methazolamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound)
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00238 | DB01006 | 188 | 300 | [
"DDInter1285",
"DDInter1040"
] | Nevirapine | Letrozole | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Moderate | 1 | [
[
[
188,
24,
300
]
],
[
[
188,
6,
8717
],
[
8717,
45,
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]
],
[
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188,
21,
28646
],
[
28646,
60,
300
]
],
[
[
188,
24,
478
],
[
478,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Letrozole"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",
... | Nevirapine (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Letrozole (Compound)
Nevirapine (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Letrozole (Compound)
Nevirapine may cause a mod... |
DB00586 | DB09101 | 1,512 | 70 | [
"DDInter537",
"DDInter633"
] | Diclofenac | Elvitegravir | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome ... | Moderate | 1 | [
[
[
1512,
24,
70
]
],
[
[
1512,
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],
[
1017,
63,
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],
[
[
1512,
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1040
],
[
1040,
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70
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],
[
[
1512,
24,
913
],
[
913,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elvitegravir"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Elvitegravir
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabr... |
DB00741 | DB01336 | 167 | 545 | [
"DDInter885",
"DDInter1198"
] | Hydrocortisone | Metocurine | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | Moderate | 1 | [
[
[
167,
24,
545
]
],
[
[
167,
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1217
],
[
1217,
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545
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[
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167,
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1031
],
[
1031,
24,
545
]
],
[
[
167,
1,
1486
],
[
1486,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
]... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Tubocurarine and Tubocurarine (Compound) resembles Metocurine (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate intera... |
DB00470 | DB00924 | 530 | 1,405 | [
"DDInter601",
"DDInter454"
] | Dronabinol | Cyclobenzaprine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
530,
24,
1405
]
],
[
[
530,
24,
649
],
[
649,
63,
1405
]
],
[
[
530,
63,
1302
],
[
1302,
1,
1405
]
],
[
[
530,
24,
1236
],
[
1236,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline an... |
DB00641 | DB06186 | 467 | 1,439 | [
"DDInter1675",
"DDInter969"
] | Simvastatin | Ipilimumab | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
467,
24,
1439
]
],
[
[
467,
63,
912
],
[
912,
24,
1439
]
],
[
[
467,
24,
1060
],
[
1060,
63,
1439
]
],
[
[
467,
24,
267
],
[
267,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Enf... |
DB00363 | DB12001 | 695 | 564 | [
"DDInter419",
"DDInter7"
] | Clozapine | Abemaciclib | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
695,
25,
564
]
],
[
[
695,
25,
868
],
[
868,
24,
564
]
],
[
[
695,
64,
600
],
[
600,
24,
564
]
],
[
[
695,
25,
982
],
[
982,
63,... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafenib",
"{u} ... | Clozapine may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Clozapine may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate i... |
DB01128 | DB01255 | 918 | 633 | [
"DDInter204",
"DDInter1078"
] | Bicalutamide | Lisdexamfetamine | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
918,
24,
633
]
],
[
[
918,
21,
28890
],
[
28890,
60,
633
]
],
[
[
918,
62,
112
],
[
112,
23,
633
]
],
[
[
918,
63,
1494
],
[
1494,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Bicalutamide",
"{u} (Compound) causes {v} (Side Effect)",
"Myocardial infarction"
],
[
"Myocardial infarction"... | Bicalutamide (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Lisdexamfetamine (Compound)
Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clin... |
DB00816 | DB01155 | 1,674 | 872 | [
"DDInter1346",
"DDInter813"
] | Orciprenaline | Gemifloxacin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1674,
24,
872
]
],
[
[
1674,
24,
739
],
[
739,
1,
872
]
],
[
[
1674,
25,
945
],
[
945,
40,
872
]
],
[
[
1674,
64,
1176
],
[
1176,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Orciprenaline may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gemifloxacin (Compoun... |
DB01024 | DB01190 | 1,096 | 568 | [
"DDInter1252",
"DDInter398"
] | Mycophenolic acid | Clindamycin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Moderate | 1 | [
[
[
1096,
24,
568
]
],
[
[
1096,
24,
1208
],
[
1208,
1,
568
]
],
[
[
1096,
21,
29180
],
[
29180,
60,
568
]
],
[
[
1096,
24,
339
],
[
339,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clindamycin"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lincomycin"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Lincomycin and Lincomycin (Compound) resembles Clindamycin (Compound)
Mycophenolic acid (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Clindamycin (Compound)
Mycoph... |
DB00317 | DB00460 | 883 | 612 | [
"DDInter810",
"DDInter1929"
] | Gefitinib | Verteporfin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
883,
24,
612
]
],
[
[
883,
21,
29044
],
[
29044,
60,
612
]
],
[
[
883,
35,
392
],
[
392,
63,
612
]
],
[
[
883,
24,
842
],
[
842,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Gefitinib",
"{u} (Compound) causes {v} (Side Effect)",
"Pneumonia"
],
[
"Pneumonia",
"{u} (Side Effect) is cause... | Gefitinib (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Verteporfin (Compound)
Gefitinib (Compound) resembles Lapatinib (Compound) and Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction t... |
DB09054 | DB14881 | 384 | 180 | [
"DDInter905",
"DDInter1329"
] | Idelalisib | Oliceridine | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
384,
25,
180
]
],
[
[
384,
63,
1094
],
[
1094,
24,
180
]
],
[
[
384,
25,
124
],
[
124,
24,
180
]
],
[
[
384,
64,
578
],
[
578,
2... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
"Metrelep... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Idelalisib may lead to a major life threatening interaction when taken with Glasdegib and Glasdegib may cause... |
DB00792 | DB00843 | 832 | 479 | [
"DDInter1878",
"DDInter583"
] | Tripelennamine | Donepezil | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
832,
24,
479
]
],
[
[
832,
24,
843
],
[
843,
1,
479
]
],
[
[
832,
6,
12523
],
[
12523,
45,
479
]
],
[
[
832,
63,
1442
],
[
1442,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Tripelennamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Tripelennamine may cause a moderate interaction that c... |
DB00501 | DB14491 | 752 | 428 | [
"DDInter380",
"DDInter725"
] | Cimetidine | Ferrous fumarate | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Used in treatment of iron deficiency anemia. | Minor | 0 | [
[
[
752,
23,
428
]
],
[
[
752,
23,
872
],
[
872,
24,
428
]
],
[
[
752,
62,
1467
],
[
1467,
24,
428
]
],
[
[
752,
23,
1459
],
[
1459,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Enoxacin and En... |
DB00069 | DB08868 | 367 | 1,011 | [
"DDInter946",
"DDInter737"
] | Interferon alfacon-1 | Fingolimod | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
367,
25,
1011
]
],
[
[
367,
24,
112
],
[
112,
23,
1011
]
],
[
[
367,
24,
242
],
[
242,
63,
1011
]
],
[
[
367,
24,
1136
],
[
1136,
... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00563 | DB12500 | 663 | 283 | [
"DDInter1174",
"DDInter714"
] | Methotrexate | Fedratinib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
663,
24,
283
]
],
[
[
663,
24,
466
],
[
466,
62,
283
]
],
[
[
663,
24,
351
],
[
351,
23,
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]
],
[
[
663,
24,
69
],
[
69,
63,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and ... |
DB06688 | DB08886 | 1,430 | 637 | [
"DDInter1677",
"DDInter126"
] | Sipuleucel-T | Asparaginase Erwinia chrysanthemi | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1430,
24,
637
]
],
[
[
1430,
63,
491
],
[
491,
24,
637
]
],
[
[
1430,
24,
250
],
[
250,
63,
637
]
],
[
[
1430,
24,
850
],
[
850,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Sipuleucel-T may cause a moderate interaction that could exacerba... |
DB00494 | DB01592 | 1,533 | 1,596 | [
"DDInter646",
"DDInter975"
] | Entacapone | Iron | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1533,
24,
1596
]
],
[
[
1533,
21,
29276
],
[
29276,
60,
1596
]
],
[
[
1533,
21,
29276
],
[
29276,
60,
1096
],
[
1096,
23,
1596
]
],
[
[
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Entacapone",
"{u} (Compound) causes {v} (Side Effect)",
"Haemoglobin"
],
[
"Haemoglobin",
"{u} (Side Effect) is caused... | Entacapone (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Iron (Compound)
Entacapone (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical eff... |
DB00470 | DB01501 | 530 | 1,118 | [
"DDInter601",
"DDInter549"
] | Dronabinol | Difenoxin | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
530,
24,
1118
]
],
[
[
530,
63,
576
],
[
576,
1,
1118
]
],
[
[
530,
24,
704
],
[
704,
1,
1118
]
],
[
[
530,
63,
78
],
[
78,
24,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methadone"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Difenoxin (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Difenoxin (Compound)
Dronabin... |
DB00377 | DB01156 | 1,494 | 593 | [
"DDInter1382",
"DDInter252"
] | Palonosetron | Bupropion | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1494,
25,
593
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
593
]
],
[
[
1494,
21,
29220
],
[
29220,
60,
593
]
],
[
[
1494,
25,
996
],
[
996,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bupr... | Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Palonosetron (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Bupropion (Compound)
Palonosetron may lead to a major life threatening interaction when taken with Bedaquil... |
DB01050 | DB05528 | 848 | 1,070 | [
"DDInter900",
"DDInter1228"
] | Ibuprofen | Mipomersen | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
848,
25,
1070
]
],
[
[
848,
25,
292
],
[
292,
64,
1070
]
],
[
[
848,
63,
1512
],
[
1512,
25,
1070
]
],
[
[
848,
24,
384
],
[
384,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
],
[
"Regorafenib",
"{u} m... | Ibuprofen may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may lead to a major life threatening interaction when taken with Mipomersen
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lead to a major life ... |
DB00749 | DB01276 | 59 | 123 | [
"DDInter699",
"DDInter706"
] | Etodolac | Exenatide | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
59,
24,
123
]
],
[
[
59,
63,
1573
],
[
1573,
24,
123
]
],
[
[
59,
24,
1039
],
[
1039,
24,
123
]
],
[
[
59,
24,
850
],
[
850,
63,... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
"... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfen... |
DB01169 | DB01208 | 57 | 945 | [
"DDInter120",
"DDInter1705"
] | Arsenic trioxide | Sparfloxacin | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
57,
25,
945
]
],
[
[
57,
64,
739
],
[
739,
1,
945
]
],
[
[
57,
6,
4973
],
[
4973,
45,
945
]
],
[
[
57,
62,
112
],
[
112,
23,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxa... | Arsenic trioxide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Arsenic trioxide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sparfloxacin (Compound)
Arsenic trioxide may cause a minor interaction that can limit c... |
DB00067 | DB00539 | 317 | 11 | [
"DDInter1921",
"DDInter1837"
] | Vasopressin | Toremifene | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
317,
25,
11
]
],
[
[
317,
23,
112
],
[
112,
62,
11
]
],
[
[
317,
24,
144
],
[
144,
63,
11
]
],
[
[
317,
24,
1250
],
[
1250,
64,
... | [
[
[
"Vasopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Toremifene
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Ol... |
DB01097 | DB01118 | 1,377 | 33 | [
"DDInter1033",
"DDInter76"
] | Leflunomide | Amiodarone | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Major | 2 | [
[
[
1377,
25,
33
]
],
[
[
1377,
25,
540
],
[
540,
1,
33
]
],
[
[
1377,
6,
7950
],
[
7950,
45,
33
]
],
[
[
1377,
21,
28779
],
[
28779,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
"{... | Leflunomide may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Leflunomide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Leflunomide (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Eff... |
DB00069 | DB09276 | 367 | 381 | [
"DDInter946",
"DDInter1682"
] | Interferon alfacon-1 | Sodium aurothiomalate | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
367,
24,
381
]
],
[
[
367,
24,
1683
],
[
1683,
24,
381
]
],
[
[
367,
63,
491
],
[
491,
24,
381
]
],
[
[
367,
24,
1480
],
[
1480,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when... |
DB01215 | DB01233 | 1,418 | 1,311 | [
"DDInter677",
"DDInter1197"
] | Estazolam | Metoclopramide | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1418,
24,
1311
]
],
[
[
1418,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1418,
63,
629
],
[
629,
24,
1311
]
],
[
[
1418,
24,
649
],
[
649... | [
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Estazolam",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is ... | Estazolam (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Metoc... |
DB00231 | DB09104 | 1,174 | 286 | [
"DDInter1761",
"DDInter1118"
] | Temazepam | Magnesium hydroxide | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
1174,
23,
286
]
],
[
[
1174,
1,
481
],
[
481,
23,
286
]
],
[
[
1174,
24,
820
],
[
820,
23,
286
]
],
[
[
1174,
40,
1382
],
[
1382,
... | [
[
[
"Temazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Temazepam",
"{u} (Compound) resembles {v} (Compound)",
"Quazepam"
],
[
"Quazepam",
"{u} may cause a minor ... | Temazepam (Compound) resembles Quazepam (Compound) and Quazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Temazepam may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can l... |
DB01009 | DB12015 | 935 | 1,033 | [
"DDInter1009",
"DDInter53"
] | Ketoprofen | Alpelisib | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
935,
24,
1033
]
],
[
[
935,
24,
738
],
[
738,
24,
1033
]
],
[
[
935,
63,
1144
],
[
1144,
24,
1033
]
],
[
[
935,
25,
1510
],
[
1510,
... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglin... |
DB04868 | DB12941 | 478 | 466 | [
"DDInter1293",
"DDInter481"
] | Nilotinib | Darolutamide | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
478,
23,
466
]
],
[
[
478,
64,
1622
],
[
1622,
23,
466
]
],
[
[
478,
24,
1623
],
[
1623,
23,
466
]
],
[
[
478,
63,
336
],
[
336,
... | [
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Voriconazo... | Nilotinib may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium and Isavuconazoniu... |
DB00443 | DB14740 | 251 | 771 | [
"DDInter195",
"DDInter881"
] | Betamethasone | Hyaluronidase | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
251,
23,
771
]
],
[
[
251,
24,
1438
],
[
1438,
23,
771
]
],
[
[
251,
40,
167
],
[
167,
23,
771
]
],
[
[
251,
1,
617
],
[
617,
23... | [
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Betamethasone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction ... |
DB00427 | DB01202 | 1,233 | 1,435 | [
"DDInter1879",
"DDInter1046"
] | Triprolidine | Levetiracetam | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Moderate | 1 | [
[
[
1233,
24,
1435
]
],
[
[
1233,
63,
701
],
[
701,
24,
1435
]
],
[
[
1233,
24,
717
],
[
717,
24,
1435
]
],
[
[
1233,
24,
820
],
[
820,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levetiracetam"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levetiracetam
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzam... |
DB01284 | DB09564 | 1,042 | 1,296 | [
"DDInter1782",
"DDInter930"
] | Tetracosactide | Insulin degludec | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1042,
24,
1296
]
],
[
[
1042,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1042,
23,
659
],
[
659,
24,
1296
]
],
[
[
1042,
24,
761
],
[
761,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Tetracosactide may cause a minor interaction that can limit clinical effects when taken with Vilante... |
DB00877 | DB00976 | 629 | 1,056 | [
"DDInter1678",
"DDInter1758"
] | Sirolimus | Telithromycin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Major | 2 | [
[
[
629,
25,
1056
]
],
[
[
629,
6,
7524
],
[
7524,
45,
1056
]
],
[
[
629,
21,
28681
],
[
28681,
60,
1056
]
],
[
[
629,
24,
1220
],
[
1220,... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telithromycin"
]
],
[
[
"Sirolimus",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Telith... | Sirolimus (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Telithromycin (Compound)
Sirolimus (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Telithromycin (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with De... |
DB00457 | DB01234 | 1,205 | 1,220 | [
"DDInter1511",
"DDInter513"
] | Prazosin | Dexamethasone | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1205,
24,
1220
]
],
[
[
1205,
24,
870
],
[
870,
1,
1220
]
],
[
[
1205,
24,
175
],
[
175,
40,
1220
]
],
[
[
1205,
63,
251
],
[
251,
... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamet... |
DB04951 | DB08893 | 187 | 271 | [
"DDInter1477",
"DDInter1229"
] | Pirfenidone | Mirabegron | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Moderate | 1 | [
[
[
187,
24,
271
]
],
[
[
187,
24,
283
],
[
283,
62,
271
]
],
[
[
187,
25,
868
],
[
868,
23,
271
]
],
[
[
187,
63,
597
],
[
597,
23,... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
]
],
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron
Pirfenidone may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may caus... |
DB00939 | DB00975 | 1,338 | 1,317 | [
"DDInter1135",
"DDInter573"
] | Meclofenamic acid | Dipyridamole | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
1338,
24,
1317
]
],
[
[
1338,
21,
28956
],
[
28956,
60,
1317
]
],
[
[
1338,
24,
714
],
[
714,
63,
1317
]
],
[
[
1338,
63,
1167
],
[
11... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Meclofenamic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Palpitations"
],
[
"Palpitations",
"{u}... | Meclofenamic acid (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dipyridamole (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when ... |
DB00005 | DB01076 | 1,057 | 700 | [
"DDInter687",
"DDInter133"
] | Etanercept | Atorvastatin | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
1057,
24,
700
]
],
[
[
1057,
24,
788
],
[
788,
1,
700
]
],
[
[
1057,
24,
303
],
[
303,
23,
700
]
],
[
[
1057,
25,
896
],
[
896,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may... |
DB00307 | DB08931 | 1,101 | 947 | [
"DDInter202",
"DDInter1600"
] | Bexarotene | Riociguat | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Moderate | 1 | [
[
[
1101,
24,
947
]
],
[
[
1101,
24,
1478
],
[
1478,
24,
947
]
],
[
[
1101,
23,
609
],
[
609,
24,
947
]
],
[
[
1101,
23,
982
],
[
982,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riociguat"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarith... |
DB08908 | DB10316 | 713 | 334 | [
"DDInter564",
"DDInter1248"
] | Dimethyl fumarate | Mumps virus strain B level jeryl lynn live antigen | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
713,
25,
334
]
],
[
[
713,
63,
1042
],
[
1042,
24,
334
]
],
[
[
713,
63,
594
],
[
594,
25,
334
]
],
[
[
713,
64,
1057
],
[
1057,
... | [
[
[
"Dimethyl fumarate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Mumps virus strain B level jeryl lynn live antigen
Dimethyl fumarate may cause a moderate interaction that c... |
DB00446 | DB00696 | 597 | 826 | [
"DDInter351",
"DDInter665"
] | Chloramphenicol | Ergotamine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Moderate | 1 | [
[
[
597,
24,
826
]
],
[
[
597,
63,
588
],
[
588,
1,
826
]
],
[
[
597,
63,
1131
],
[
1131,
40,
826
]
],
[
[
597,
24,
628
],
[
628,
1,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergotamine"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylergometrine... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergotamine (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) rese... |
DB00353 | DB06764 | 588 | 1,090 | [
"DDInter1187",
"DDInter1787"
] | Methylergometrine | Tetryzoline (nasal) | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Major | 2 | [
[
[
588,
25,
1090
]
],
[
[
588,
40,
628
],
[
628,
25,
1090
]
],
[
[
588,
1,
1131
],
[
1131,
25,
1090
]
],
[
[
588,
40,
628
],
[
628,
... | [
[
[
"Methylergometrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetryzoline"
]
],
[
[
"Methylergometrine",
"{u} (Compound) resembles {v} (Compound)",
"Ergometrine"
],
[
"Ergometrine",
"{u} may lead to a maj... | Methylergometrine may lead to a major life threatening interaction when taken with Tetryzoline
Methylergometrine (Compound) resembles Ergometrine (Compound) and Ergometrine may lead to a major life threatening interaction when taken with Tetryzoline
Methylergometrine (Compound) resembles Methysergide (Compound) and Met... |
DB00448 | DB00705 | 1,215 | 441 | [
"DDInter1022",
"DDInter496"
] | Lansoprazole | Delavirdine | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
1215,
24,
441
]
],
[
[
1215,
6,
10215
],
[
10215,
45,
441
]
],
[
[
1215,
21,
28709
],
[
28709,
60,
441
]
],
[
[
1215,
24,
609
],
[
609... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Lansoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Comp... | Lansoprazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Delavirdine (Compound)
Lansoprazole (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Lansoprazole may cause a moderate interaction that could exacerbate diseases when ta... |
DB05351 | DB08901 | 101 | 1,468 | [
"DDInter519",
"DDInter1492"
] | Dexlansoprazole | Ponatinib | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Minor | 0 | [
[
[
101,
23,
1468
]
],
[
[
101,
63,
478
],
[
478,
24,
1468
]
],
[
[
101,
24,
1375
],
[
1375,
63,
1468
]
],
[
[
101,
64,
1195
],
[
1195,
... | [
[
[
"Dexlansoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
]
],
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
... | Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and ... |
DB00902 | DB01238 | 104 | 673 | [
"DDInter1168",
"DDInter118"
] | Methdilazine | Aripiprazole | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
104,
24,
673
]
],
[
[
104,
63,
827
],
[
827,
40,
673
]
],
[
[
104,
74,
1630
],
[
1630,
1,
673
]
],
[
[
104,
1,
1321
],
[
1321,
4... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Methdilazine (Compound) resembles Perphenazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Per... |
DB00738 | DB08865 | 485 | 1,593 | [
"DDInter1420",
"DDInter448"
] | Pentamidine | Crizotinib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
485,
25,
1593
]
],
[
[
485,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
485,
7,
5295
],
[
5295,
45,
1593
]
],
[
[
485,
7,
1720
],
[
1720,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizo... | Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Pentamidine (Compound) upregulates CDK7 (Gene) and CDK7 (Gene) is bound by Crizotinib (Compound)
Pentamidine (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Crizotinib (Compound)
Pentamidine (Compound) do... |
DB00414 | DB06077 | 590 | 879 | [
"DDInter16",
"DDInter1102"
] | Acetohexamide | Lumateperone | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
590,
24,
879
]
],
[
[
590,
24,
1281
],
[
1281,
63,
879
]
],
[
[
590,
63,
1645
],
[
1645,
24,
879
]
],
[
[
590,
24,
597
],
[
597,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Metformin a... |
DB00092 | DB00851 | 58 | 611 | [
"DDInter40",
"DDInter463"
] | Alefacept | Dacarbazine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
58,
24,
611
]
],
[
[
58,
24,
141
],
[
141,
24,
611
]
],
[
[
58,
24,
850
],
[
850,
63,
611
]
],
[
[
58,
63,
305
],
[
305,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin ... |
DB00388 | DB11827 | 1,636 | 433 | [
"DDInter1453",
"DDInter669"
] | Phenylephrine | Ertugliflozin | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1636,
24,
433
]
],
[
[
1636,
24,
1121
],
[
1121,
24,
433
]
],
[
[
1636,
63,
1000
],
[
1000,
24,
433
]
],
[
[
1636,
1,
874
],
[
874,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
],... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Guanadrel an... |
DB00444 | DB04868 | 63 | 478 | [
"DDInter1765",
"DDInter1293"
] | Teniposide | Nilotinib | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
63,
24,
478
]
],
[
[
63,
24,
1468
],
[
1468,
63,
478
]
],
[
[
63,
5,
11555
],
[
11555,
44,
478
]
],
[
[
63,
6,
6017
],
[
6017,
4... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Teniposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib ... |
DB00342 | DB00745 | 1,181 | 307 | [
"DDInter1770",
"DDInter1236"
] | Terfenadine | Modafinil | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Moderate | 1 | [
[
[
1181,
24,
307
]
],
[
[
1181,
24,
1236
],
[
1236,
40,
307
]
],
[
[
1181,
63,
847
],
[
847,
40,
307
]
],
[
[
1181,
64,
576
],
[
576,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
],
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Modafinil (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Modafinil (Co... |
DB00827 | DB01005 | 646 | 995 | [
"DDInter383",
"DDInter894"
] | Cinoxacin | Hydroxyurea | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Minor | 0 | [
[
[
646,
23,
995
]
],
[
[
646,
21,
28845
],
[
28845,
60,
995
]
],
[
[
646,
62,
1238
],
[
1238,
24,
995
]
],
[
[
646,
23,
869
],
[
869,
... | [
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Cinoxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is caused by {v}... | Cinoxacin (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Hydroxyurea (Compound)
Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Pentostatin and Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea
Ci... |
DB00620 | DB01009 | 175 | 935 | [
"DDInter1855",
"DDInter1009"
] | Triamcinolone | Ketoprofen | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
175,
24,
935
]
],
[
[
175,
63,
1523
],
[
1523,
40,
935
]
],
[
[
175,
24,
1274
],
[
1274,
24,
935
]
],
[
[
175,
24,
1263
],
[
1263,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction th... |
DB06772 | DB08816 | 310 | 578 | [
"DDInter259",
"DDInter1802"
] | Cabazitaxel | Ticagrelor | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
310,
24,
578
]
],
[
[
310,
6,
4973
],
[
4973,
45,
578
]
],
[
[
310,
21,
28646
],
[
28646,
60,
578
]
],
[
[
310,
63,
336
],
[
336,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Cabazitaxel",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Cabazitaxel (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Cabazitaxel (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Cabazitaxel may cause a ... |
DB00005 | DB12159 | 1,057 | 12 | [
"DDInter687",
"DDInter609"
] | Etanercept | Dupilumab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Major | 2 | [
[
[
1057,
25,
12
]
],
[
[
1057,
23,
1461
],
[
1461,
23,
12
]
],
[
[
1057,
24,
599
],
[
599,
24,
12
]
],
[
[
1057,
25,
287
],
[
287,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dupilumab"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Dupilumab
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab ... |
DB08870 | DB12095 | 850 | 179 | [
"DDInter228",
"DDInter1760"
] | Brentuximab vedotin | Telotristat ethyl | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
850,
24,
179
]
],
[
[
850,
63,
79
],
[
79,
24,
179
]
],
[
[
850,
24,
214
],
[
214,
24,
179
]
],
[
[
850,
24,
283
],
[
283,
63,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"So... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01261 | DB06595 | 170 | 1,491 | [
"DDInter1679",
"DDInter1214"
] | Sitagliptin | Midostaurin | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
170,
24,
1491
]
],
[
[
170,
63,
1148
],
[
1148,
24,
1491
]
],
[
[
170,
24,
927
],
[
927,
63,
1491
]
],
[
[
170,
23,
52
],
[
52,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib an... |
DB01045 | DB05676 | 463 | 1,513 | [
"DDInter1590",
"DDInter111"
] | Rifampicin | Apremilast | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Major | 2 | [
[
[
463,
25,
1513
]
],
[
[
463,
24,
1421
],
[
1421,
63,
1513
]
],
[
[
463,
1,
690
],
[
690,
24,
1513
]
],
[
[
463,
62,
1101
],
[
1101,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apremilast"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
],
[
"Betrixaban... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Betrixaban may cause a moderate interaction that could exacerbate diseases when taken with Apremilast
Rifampicin (Compound) resembles Rifabutin (Compound) and Rifabutin may cause a moderate interaction that could e... |
DB00494 | DB11186 | 1,533 | 1,609 | [
"DDInter646",
"DDInter1427"
] | Entacapone | Pentoxyverine | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1533,
24,
1609
]
],
[
[
1533,
24,
104
],
[
104,
24,
1609
]
],
[
[
1533,
63,
999
],
[
999,
24,
1609
]
],
[
[
1533,
40,
1062
],
[
1062,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazi... |
DB00692 | DB11130 | 274 | 407 | [
"DDInter1448",
"DDInter1344"
] | Phentolamine | Opium | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
274,
24,
407
]
],
[
[
274,
63,
558
],
[
558,
24,
407
]
],
[
[
274,
24,
1322
],
[
1322,
24,
407
]
],
[
[
274,
24,
1399
],
[
1399,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
],
[
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Opium
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil ... |
DB01101 | DB01610 | 60 | 248 | [
"DDInter285",
"DDInter1912"
] | Capecitabine | Valganciclovir | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
60,
24,
248
]
],
[
[
60,
63,
563
],
[
563,
1,
248
]
],
[
[
60,
21,
29209
],
[
29209,
60,
248
]
],
[
[
60,
63,
141
],
[
141,
24,
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Capecitabine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Capecitabine may cause a moderat... |
DB00951 | DB09049 | 1,072 | 1,135 | [
"DDInter986",
"DDInter1261"
] | Isoniazid | Naloxegol | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
1072,
23,
1135
]
],
[
[
1072,
24,
971
],
[
971,
62,
1135
]
],
[
[
1072,
24,
478
],
[
478,
23,
1135
]
],
[
[
1072,
24,
1017
],
[
1017,
... | [
[
[
"Isoniazid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotini... |
DB02701 | DB09061 | 1,632 | 1,627 | [
"DDInter1289",
"DDInter284"
] | Nicotinamide | Cannabidiol | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1632,
24,
1627
]
],
[
[
1632,
24,
384
],
[
384,
23,
1627
]
],
[
[
1632,
24,
1613
],
[
1613,
63,
1627
]
],
[
[
1632,
63,
267
],
[
267,
... | [
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta... |
DB00488 | DB01208 | 196 | 945 | [
"DDInter57",
"DDInter1705"
] | Altretamine | Sparfloxacin | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
196,
23,
945
]
],
[
[
196,
23,
739
],
[
739,
1,
945
]
],
[
[
196,
62,
1176
],
[
1176,
1,
945
]
],
[
[
196,
21,
28751
],
[
28751,
... | [
[
[
"Altretamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Altretamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Altretamine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Altretamine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (... |
DB00363 | DB00835 | 695 | 100 | [
"DDInter419",
"DDInter245"
] | Clozapine | Brompheniramine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
695,
24,
100
]
],
[
[
695,
24,
832
],
[
832,
24,
100
]
],
[
[
695,
24,
28
],
[
28,
40,
100
]
],
[
[
695,
24,
649
],
[
649,
63,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl ... |
DB00471 | DB00776 | 201 | 1,335 | [
"DDInter1242",
"DDInter1360"
] | Montelukast | Oxcarbazepine | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
201,
24,
1335
]
],
[
[
201,
24,
1236
],
[
1236,
1,
1335
]
],
[
[
201,
6,
8374
],
[
8374,
45,
1335
]
],
[
[
201,
21,
29058
],
[
29058,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
],
... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Oxcarbazepine (Compound)
Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxcarbazepine (Compound)
Montelukast (Compound) causes Hepatitis (Side Effect... |
DB00987 | DB10316 | 1,224 | 334 | [
"DDInter460",
"DDInter1248"
] | Cytarabine | Mumps virus strain B level jeryl lynn live antigen | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1224,
25,
334
]
],
[
[
1224,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1224,
24,
328
],
[
328,
25,
334
]
],
[
[
1224,
25,
908
],
[
908,
... | [
[
[
"Cytarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Cytarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Cytarabine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopur... |
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