drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00443 | DB14444 | 251 | 151 | [
"DDInter195",
"DDInter924"
] | Betamethasone | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
251,
24,
151
]
],
[
[
251,
63,
66
],
[
66,
24,
151
]
],
[
[
251,
24,
1619
],
[
1619,
24,
151
]
],
[
[
251,
1,
1573
],
[
1573,
24... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that c... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Betamethasone may cause a moderate... |
DB00776 | DB09330 | 1,335 | 985 | [
"DDInter1360",
"DDInter1352"
] | Oxcarbazepine | Osimertinib | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1335,
24,
985
]
],
[
[
1335,
62,
168
],
[
168,
23,
985
]
],
[
[
1335,
24,
1478
],
[
1478,
24,
985
]
],
[
[
1335,
63,
134
],
[
134,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
... | Oxcarbazepine may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivac... |
DB00773 | DB10315 | 896 | 1,137 | [
"DDInter702",
"DDInter1127"
] | Etoposide | Measles virus vaccine live attenuated | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
896,
25,
1137
]
],
[
[
896,
64,
581
],
[
581,
25,
1137
]
],
[
[
896,
24,
384
],
[
384,
25,
1137
]
],
[
[
896,
63,
1101
],
[
1101,
... | [
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
"... | Etoposide may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib ... |
DB00860 | DB01010 | 891 | 61 | [
"DDInter1513",
"DDInter622"
] | Prednisolone | Edrophonium | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Moderate | 1 | [
[
[
891,
24,
61
]
],
[
[
891,
24,
1372
],
[
1372,
63,
61
]
],
[
[
891,
21,
29260
],
[
29260,
60,
61
]
],
[
[
891,
25,
1011
],
[
1011,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neostigmine"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Neostigmine and Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium
Prednisolone (Compound) causes Conjunctival hyperaemia (Side Effect) and Conjunctival hyperaemia (Side Effe... |
DB01278 | DB09389 | 1,021 | 517 | [
"DDInter1506",
"DDInter1315"
] | Pramlintide | Norgestrel | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1021,
24,
517
]
],
[
[
1021,
24,
1254
],
[
1254,
24,
517
]
],
[
[
1021,
63,
629
],
[
629,
24,
517
]
],
[
[
1021,
24,
1296
],
[
1296,
... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Sirol... |
DB00372 | DB00968 | 999 | 1,551 | [
"DDInter1793",
"DDInter1185"
] | Thiethylperazine | Methyldopa | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Moderate | 1 | [
[
[
999,
24,
1551
]
],
[
[
999,
24,
817
],
[
817,
40,
1551
]
],
[
[
999,
24,
874
],
[
874,
24,
1551
]
],
[
[
999,
24,
959
],
[
959,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyldopa"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
]... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Methyldopa (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction ... |
DB00086 | DB00302 | 1,167 | 335 | [
"DDInter1712",
"DDInter1844"
] | Streptokinase | Tranexamic acid | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986. | Moderate | 1 | [
[
[
1167,
24,
335
]
],
[
[
1167,
24,
578
],
[
578,
62,
335
]
],
[
[
1167,
23,
539
],
[
539,
62,
582
],
[
582,
24,
335
]
],
[
[
1167,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tranexamic acid"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Tranexamic acid
Streptokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and C... |
DB00557 | DB00981 | 252 | 1,528 | [
"DDInter895",
"DDInter1463"
] | Hydroxyzine | Physostigmine (ophthalmic) | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Moderate | 1 | [
[
[
252,
24,
1528
]
],
[
[
252,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
252,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
252,
24,
543
],
[
543,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effect) ... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Hydroxyzine (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00690 | DB01069 | 1,216 | 401 | [
"DDInter762",
"DDInter1533"
] | Flurazepam | Promethazine | A benzodiazepine derivative used mainly as a hypnotic. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1216,
24,
401
]
],
[
[
1216,
40,
11275
],
[
11275,
40,
401
]
],
[
[
1216,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1216,
40,
1237
],
[
123... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Flurazepam",
"{u} (Compound) resembles {v} (Compound)",
"Chlorprothixene"
],
[
"Chlorprothixene",
"{u} (Compou... | Flurazepam (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Promethazine (Compound)
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Prome... |
DB01208 | DB01229 | 945 | 973 | [
"DDInter1705",
"DDInter1377"
] | Sparfloxacin | Paclitaxel | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Minor | 0 | [
[
[
945,
23,
973
]
],
[
[
945,
6,
4973
],
[
4973,
45,
973
]
],
[
[
945,
18,
3833
],
[
3833,
46,
973
]
],
[
[
945,
6,
3199
],
[
3199,
... | [
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Paclitaxel"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Sparfloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paclitaxel (Compound)
Sparfloxacin (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is upregulated by Paclitaxel (Compound)
Sparfloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Paclitaxel (Compound)
Sparfloxacin (Co... |
DB00321 | DB00692 | 21 | 274 | [
"DDInter78",
"DDInter1448"
] | Amitriptyline | Phentolamine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
21,
24,
274
]
],
[
[
21,
6,
11204
],
[
11204,
45,
274
]
],
[
[
21,
21,
29118
],
[
29118,
60,
274
]
],
[
[
21,
24,
530
],
[
530,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"SIGMAR1"
],
[
"SIGMAR1",
"{u} (Gene) is bound by {v} (C... | Amitriptyline (Compound) binds SIGMAR1 (Gene) and SIGMAR1 (Gene) is bound by Phentolamine (Compound)
Amitriptyline (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00939 | DB09030 | 1,338 | 840 | [
"DDInter1135",
"DDInter1945"
] | Meclofenamic acid | Vorapaxar | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
1338,
25,
840
]
],
[
[
1338,
24,
885
],
[
885,
24,
840
]
],
[
[
1338,
63,
121
],
[
121,
24,
840
]
],
[
[
1338,
24,
738
],
[
738,
... | [
[
[
"Meclofenamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Fenf... |
DB00728 | DB09407 | 1,610 | 853 | [
"DDInter1612",
"DDInter1114"
] | Rocuronium | Magnesium chloride | Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechan... | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
1610,
24,
853
]
],
[
[
1610,
63,
964
],
[
964,
24,
853
]
],
[
[
1610,
24,
1669
],
[
1669,
24,
853
]
],
[
[
1610,
1,
728
],
[
728,
... | [
[
[
"Rocuronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Rocuronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
],... | Rocuronium may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Rocuronium may cause a moderate interaction that could exacerbate diseases when taken with Minocycline... |
DB00593 | DB01142 | 1,464 | 1,264 | [
"DDInter695",
"DDInter593"
] | Ethosuximide | Doxepin | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1464,
24,
1264
]
],
[
[
1464,
24,
401
],
[
401,
24,
1264
]
],
[
[
1464,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
1464,
24,
649
],
[
649,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and D... |
DB00862 | DB01268 | 1,005 | 1,151 | [
"DDInter1918",
"DDInter1731"
] | Vardenafil | Sunitinib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1005,
24,
1151
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
1151
]
],
[
[
1005,
21,
29269
],
[
29269,
60,
1151
]
],
[
[
1005,
24,
112
],
[
11... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sunitinib (Compound)
Vardenafil (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Sunitinib (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00741 | DB01080 | 167 | 855 | [
"DDInter885",
"DDInter1933"
] | Hydrocortisone | Vigabatrin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Major | 2 | [
[
[
167,
25,
855
]
],
[
[
167,
21,
28719
],
[
28719,
60,
855
]
],
[
[
167,
25,
770
],
[
770,
24,
855
]
],
[
[
167,
1,
617
],
[
617,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vigabatrin"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Compou... | Hydrocortisone (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vigabatrin (Compound)
Hydrocortisone may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Hydrocortis... |
DB01073 | DB14811 | 1,488 | 385 | [
"DDInter745",
"DDInter979"
] | Fludarabine | Isatuximab | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
1488,
24,
385
]
],
[
[
1488,
24,
1362
],
[
1362,
24,
385
]
],
[
[
1488,
63,
377
],
[
377,
24,
385
]
],
[
[
1488,
40,
372
],
[
372,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin... |
DB08899 | DB09381 | 129 | 192 | [
"DDInter649",
"DDInter678"
] | Enzalutamide | Esterified estrogens | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
129,
24,
192
]
],
[
[
129,
63,
1264
],
[
1264,
23,
192
]
],
[
[
129,
25,
1019
],
[
1019,
63,
192
]
],
[
[
129,
24,
1450
],
[
1450,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Enzalutamide may lead to a major life threatening interaction when taken with Deflazacort and Deflazacort ma... |
DB00202 | DB00254 | 190 | 964 | [
"DDInter1716",
"DDInter598"
] | Succinylcholine | Doxycycline | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Moderate | 1 | [
[
[
190,
24,
964
]
],
[
[
190,
24,
1572
],
[
1572,
40,
964
]
],
[
[
190,
24,
1620
],
[
1620,
1,
964
]
],
[
[
190,
24,
1424
],
[
1424,
... | [
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]
],
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
... | Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Doxycycline (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles... |
DB05294 | DB06788 | 1,069 | 1,616 | [
"DDInter1917",
"DDInter864"
] | Vandetanib | Histrelin | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
1069,
25,
1616
]
],
[
[
1069,
62,
112
],
[
112,
23,
1616
]
],
[
[
1069,
64,
1664
],
[
1664,
24,
1616
]
],
[
[
1069,
25,
1342
],
[
1342... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Vandetanib may lead to a major life threatening interaction when taken with Risperidone and Risperidone may cau... |
DB00734 | DB06699 | 1,664 | 774 | [
"DDInter1605",
"DDInter493"
] | Risperidone | Degarelix | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1664,
24,
774
]
],
[
[
1664,
63,
521
],
[
521,
1,
774
]
],
[
[
1664,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1664,
23,
112
],
[
112,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Risperidone (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Risperidone may cause a minor interaction that... |
DB01406 | DB04868 | 984 | 478 | [
"DDInter472",
"DDInter1293"
] | Danazol | Nilotinib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
984,
24,
478
]
],
[
[
984,
6,
8374
],
[
8374,
45,
478
]
],
[
[
984,
7,
4759
],
[
4759,
46,
478
]
],
[
[
984,
18,
8587
],
[
8587,
... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Danazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Danazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Danazol (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Nilotinib (Compound)
Danazol (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Nilotinib (Compound)
Danazol (Compound) binds... |
DB00242 | DB00444 | 1,064 | 63 | [
"DDInter392",
"DDInter1765"
] | Cladribine | Teniposide | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Major | 2 | [
[
[
1064,
25,
63
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
63
]
],
[
[
1064,
6,
17404
],
[
17404,
45,
63
]
],
[
[
1064,
7,
9187
],
[
9187,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teniposide"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated b... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Teniposide (Compound)
Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Teniposide (Compound)
Cladribine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Teniposide (Compoun... |
DB00313 | DB04837 | 556 | 649 | [
"DDInter1913",
"DDInter407"
] | Valproic acid | Clofedanol | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
556,
24,
649
]
],
[
[
556,
24,
1376
],
[
1376,
24,
649
]
],
[
[
556,
24,
832
],
[
832,
40,
649
]
],
[
[
556,
63,
701
],
[
701,
2... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Tripe... |
DB00980 | DB14723 | 969 | 159 | [
"DDInter1564",
"DDInter1026"
] | Ramelteon | Larotrectinib | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
969,
24,
159
]
],
[
[
969,
24,
222
],
[
222,
23,
159
]
],
[
[
969,
24,
98
],
[
98,
24,
159
]
],
[
[
969,
63,
530
],
[
530,
24,
... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatre... |
DB00065 | DB00531 | 581 | 450 | [
"DDInter923",
"DDInter456"
] | Infliximab | Cyclophosphamide | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Major | 2 | [
[
[
581,
25,
450
]
],
[
[
581,
25,
1001
],
[
1001,
40,
450
]
],
[
[
581,
63,
491
],
[
491,
23,
450
]
],
[
[
581,
24,
367
],
[
367,
2... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclophosphamide"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mechlorethamine"
],
[
"Mechlorethamin... | Infliximab may lead to a major life threatening interaction when taken with Mechlorethamine and Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a minor in... |
DB04868 | DB09054 | 478 | 384 | [
"DDInter1293",
"DDInter905"
] | Nilotinib | Idelalisib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
478,
25,
384
]
],
[
[
478,
63,
222
],
[
222,
23,
384
]
],
[
[
478,
64,
318
],
[
318,
23,
384
]
],
[
[
478,
24,
1627
],
[
1627,
6... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Nilotinib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may caus... |
DB00188 | DB10795 | 168 | 221 | [
"DDInter222",
"DDInter1486"
] | Bortezomib | Poliovirus type 1 antigen (formaldehyde inactivated) | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
168,
24,
221
]
],
[
[
168,
24,
36
],
[
36,
24,
221
]
],
[
[
168,
64,
581
],
[
581,
24,
221
]
],
[
[
168,
63,
599
],
[
599,
24,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Bortezomib may lead to a major life threatening interaction when taken wit... |
DB00095 | DB01024 | 66 | 1,096 | [
"DDInter623",
"DDInter1252"
] | Efalizumab | Mycophenolic acid | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
66,
24,
1096
]
],
[
[
66,
24,
955
],
[
955,
1,
1096
]
],
[
[
66,
23,
1193
],
[
1193,
62,
1096
]
],
[
[
66,
23,
1461
],
[
1461,
2... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofeti... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may caus... |
DB00867 | DB13928 | 1,052 | 1,385 | [
"DDInter1606",
"DDInter1660"
] | Ritodrine | Semaglutide | Adrenergic beta-agonist used to control premature labor. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1052,
24,
1385
]
],
[
[
1052,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
1052,
62,
891
],
[
891,
24,
1385
]
],
[
[
1052,
63,
1445
],
[
1445... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Ritodrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasireotid... | Ritodrine may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Ritodrine may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Prednisolone may cau... |
DB00945 | DB01197 | 1,479 | 1,603 | [
"DDInter20",
"DDInter292"
] | Acetylsalicylic acid | Captopril | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1479,
24,
1603
]
],
[
[
1479,
63,
610
],
[
610,
1,
1603
]
],
[
[
1479,
5,
11576
],
[
11576,
44,
1603
]
],
[
[
1479,
6,
1829
],
[
1829,... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapri... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Acetylsalicylic acid (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Captopril (Compound)
Acetyls... |
DB00060 | DB00609 | 912 | 595 | [
"DDInter947",
"DDInter694"
] | Interferon beta-1a | Ethionamide | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Moderate | 1 | [
[
[
912,
24,
595
]
],
[
[
912,
24,
372
],
[
372,
63,
595
]
],
[
[
912,
24,
367
],
[
367,
24,
595
]
],
[
[
912,
63,
305
],
[
305,
24,... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with In... |
DB00404 | DB01390 | 523 | 1,117 | [
"DDInter54",
"DDInter1683"
] | Alprazolam | Sodium bicarbonate | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
523,
23,
1117
]
],
[
[
523,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
523,
23,
1220
],
[
1220,
23,
1117
]
],
[
[
523,
40,
1119
],
[
1119... | [
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Alprazolam",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is ca... | Alprazolam (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Alprazolam may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with S... |
DB00220 | DB14723 | 798 | 159 | [
"DDInter1276",
"DDInter1026"
] | Nelfinavir | Larotrectinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
798,
25,
159
]
],
[
[
798,
23,
222
],
[
222,
23,
159
]
],
[
[
798,
24,
466
],
[
466,
23,
159
]
],
[
[
798,
25,
1135
],
[
1135,
2... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Nelfinavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
"Sibutram... | Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Dar... |
DB00427 | DB01209 | 1,233 | 1,359 | [
"DDInter1879",
"DDInter531"
] | Triprolidine | Dezocine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1233,
24,
1359
]
],
[
[
1233,
24,
234
],
[
234,
1,
1359
]
],
[
[
1233,
24,
717
],
[
717,
24,
1359
]
],
[
[
1233,
63,
1594
],
[
1594,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide may cause a moderate inte... |
DB00317 | DB01320 | 883 | 651 | [
"DDInter810",
"DDInter783"
] | Gefitinib | Fosphenytoin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
883,
24,
651
]
],
[
[
883,
23,
307
],
[
307,
1,
651
]
],
[
[
883,
63,
362
],
[
362,
1,
651
]
],
[
[
883,
24,
998
],
[
998,
1,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Gefitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Gefitinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Gefi... |
DB00159 | DB06209 | 940 | 256 | [
"DDInter903",
"DDInter1508"
] | Icosapent | Prasugrel | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
940,
24,
256
]
],
[
[
940,
21,
28792
],
[
28792,
60,
256
]
],
[
[
940,
24,
1479
],
[
1479,
24,
256
]
],
[
[
940,
24,
578
],
[
578,
... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Icosapent",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
... | Icosapent (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Prasugrel (Compound)
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that ... |
DB00836 | DB04843 | 543 | 1,511 | [
"DDInter1088",
"DDInter1149"
] | Loperamide | Mepenzolate | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
543,
35,
1511
]
],
[
[
543,
63,
675
],
[
675,
24,
1511
]
],
[
[
543,
24,
537
],
[
537,
24,
1511
]
],
[
[
543,
1,
1413
],
[
1413,
... | [
[
[
"Loperamide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken ... | Loperamide (Compound) resembles Mepenzolate (Compound) and
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Loperamide may cause a moderate inte... |
DB00001 | DB01166 | 1,578 | 477 | [
"DDInter1037",
"DDInter379"
] | Lepirudin | Cilostazol | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
1578,
25,
477
]
],
[
[
1578,
23,
297
],
[
297,
62,
477
]
],
[
[
1578,
25,
126
],
[
126,
23,
477
]
],
[
[
1578,
24,
109
],
[
109,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Lepirudin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction ... |
DB01191 | DB08918 | 1,039 | 41 | [
"DDInter518",
"DDInter1059"
] | Dexfenfluramine | Levomilnacipran | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Major | 2 | [
[
[
1039,
25,
41
]
],
[
[
1039,
25,
901
],
[
901,
40,
41
]
],
[
[
1039,
64,
1349
],
[
1349,
40,
41
]
],
[
[
1039,
6,
10215
],
[
10215,
... | [
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
],
[
"Milnacipr... | Dexfenfluramine may lead to a major life threatening interaction when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Dexfenfluramine may lead to a major life threatening interaction when taken with Meperidine and Meperidine (Compound) resembles Levomilnacipran (Compound)
Dexfenfl... |
DB01215 | DB01377 | 1,418 | 1,283 | [
"DDInter677",
"DDInter1119"
] | Estazolam | Magnesium oxide | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
1418,
23,
1283
]
],
[
[
1418,
1,
905
],
[
905,
23,
1283
]
],
[
[
1418,
40,
1174
],
[
1174,
23,
1283
]
],
[
[
1418,
63,
752
],
[
752,
... | [
[
[
"Estazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Estazolam",
"{u} (Compound) resembles {v} (Compound)",
"Lorazepam"
],
[
"Lorazepam",
"{u} may cause a minor in... | Estazolam (Compound) resembles Lorazepam (Compound) and Lorazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Estazolam (Compound) resembles Temazepam (Compound) and Temazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
... |
DB06777 | DB08870 | 780 | 850 | [
"DDInter348",
"DDInter228"
] | Chenodeoxycholic acid | Brentuximab vedotin | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
780,
24,
850
]
],
[
[
780,
63,
267
],
[
267,
24,
850
]
],
[
[
780,
24,
1412
],
[
1412,
63,
850
]
],
[
[
780,
25,
1510
],
[
1510,
... | [
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when t... |
DB00539 | DB01149 | 11 | 851 | [
"DDInter1837",
"DDInter1274"
] | Toremifene | Nefazodone | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Major | 2 | [
[
[
11,
25,
851
]
],
[
[
11,
25,
252
],
[
252,
40,
851
]
],
[
[
11,
25,
1178
],
[
1178,
1,
851
]
],
[
[
11,
24,
673
],
[
673,
40,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxyzine"
],
[
"Hydroxyzine",
"{u}... | Toremifene may lead to a major life threatening interaction when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Nefazodone (Compound)
Toremifene may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Nefazodone (Compound)
Toremifene may cau... |
DB08890 | DB11089 | 16 | 338 | [
"DDInter1069",
"DDInter579"
] | Linaclotide | Docusate | Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin deri... | Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation. Docusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass . Docusate can be orally or rectally administered. Docusate is on the World Health Organization's... | Minor | 0 | [
[
[
16,
23,
338
]
],
[
[
16,
23,
720
],
[
720,
24,
338
]
],
[
[
16,
62,
355
],
[
355,
24,
338
]
],
[
[
16,
23,
720
],
[
720,
63,
... | [
[
[
"Linaclotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Docusate"
]
],
[
[
"Linaclotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mineral oil"
],
[
... | Linaclotide may cause a minor interaction that can limit clinical effects when taken with Mineral oil and Mineral oil may cause a moderate interaction that could exacerbate diseases when taken with Docusate
Linaclotide may cause a minor interaction that can limit clinical effects when taken with Lactulose and Lactulose... |
DB00067 | DB01218 | 317 | 1,493 | [
"DDInter1921",
"DDInter852"
] | Vasopressin | Halofantrine | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
317,
25,
1493
]
],
[
[
317,
23,
112
],
[
112,
23,
1493
]
],
[
[
317,
24,
770
],
[
770,
24,
1493
]
],
[
[
317,
24,
144
],
[
144,
... | [
[
[
"Vasopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Halofantrine
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and... |
DB01211 | DB11796 | 609 | 1,612 | [
"DDInter393",
"DDInter786"
] | Clarithromycin | Fostemsavir | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
609,
24,
1612
]
],
[
[
609,
24,
98
],
[
98,
23,
1612
]
],
[
[
609,
63,
1324
],
[
1324,
23,
1612
]
],
[
[
609,
25,
1476
],
[
1476,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and T... |
DB00209 | DB09272 | 352 | 412 | [
"DDInter1886",
"DDInter632"
] | Trospium | Eluxadoline | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
352,
24,
412
]
],
[
[
352,
24,
1594
],
[
1594,
24,
412
]
],
[
[
352,
24,
1536
],
[
1536,
63,
412
]
],
[
[
352,
35,
1192
],
[
1192,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Belladonna and Belladonn... |
DB00717 | DB09045 | 1,197 | 52 | [
"DDInter1312",
"DDInter607"
] | Norethisterone | Dulaglutide | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1197,
24,
52
]
],
[
[
1197,
24,
170
],
[
170,
23,
52
]
],
[
[
1197,
24,
609
],
[
609,
24,
52
]
],
[
[
1197,
40,
989
],
[
989,
24... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromyc... |
DB00357 | DB11986 | 1,051 | 484 | [
"DDInter71",
"DDInter648"
] | Aminoglutethimide | Entrectinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1051,
24,
484
]
],
[
[
1051,
23,
271
],
[
271,
23,
484
]
],
[
[
1051,
24,
466
],
[
466,
62,
484
]
],
[
[
1051,
24,
1135
],
[
1135,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
... | Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Darolutami... |
DB08868 | DB08879 | 1,011 | 632 | [
"DDInter737",
"DDInter173"
] | Fingolimod | Belimumab | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Major | 2 | [
[
[
1011,
25,
632
]
],
[
[
1011,
25,
713
],
[
713,
63,
632
]
],
[
[
1011,
24,
1270
],
[
1270,
63,
632
]
],
[
[
1011,
64,
1184
],
[
1184,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belimumab"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dimethyl fumarate"
],
[
"Dimethyl fumarate",... | Fingolimod may lead to a major life threatening interaction when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Belimumab
Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified pro... |
DB00539 | DB05294 | 11 | 1,069 | [
"DDInter1837",
"DDInter1917"
] | Toremifene | Vandetanib | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
11,
25,
1069
]
],
[
[
11,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
11,
7,
3051
],
[
3051,
45,
1069
]
],
[
[
11,
21,
28719
],
[
28719,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vandeta... | Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Toremifene (Compound) upregulates ERBB3 (Gene) and ERBB3 (Gene) is bound by Vandetanib (Compound)
Toremifene (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Toremifene may cause a... |
DB00889 | DB08903 | 1,133 | 996 | [
"DDInter840",
"DDInter170"
] | Granisetron | Bedaquiline | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
1133,
25,
996
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1133,
21,
29282
],
[
29282,
60,
996
]
],
[
[
1133,
23,
112
],
[
112,
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Beda... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Granisetron (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00398 | DB06663 | 79 | 1,154 | [
"DDInter1702",
"DDInter1398"
] | Sorafenib | Pasireotide | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
79,
25,
1154
]
],
[
[
79,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
79,
23,
112
],
[
112,
23,
1154
]
],
[
[
79,
24,
663
],
[
663,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Sorafenib",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused by ... | Sorafenib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00649 | DB09065 | 231 | 760 | [
"DDInter1710",
"DDInter424"
] | Stavudine | Cobicistat | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
231,
24,
760
]
],
[
[
231,
64,
1101
],
[
1101,
23,
760
]
],
[
[
231,
24,
14
],
[
14,
24,
760
]
],
[
[
231,
63,
168
],
[
168,
24,... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Stavudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",... | Stavudine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause ... |
DB00976 | DB08899 | 1,056 | 129 | [
"DDInter1758",
"DDInter649"
] | Telithromycin | Enzalutamide | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1056,
25,
129
]
],
[
[
1056,
24,
918
],
[
918,
1,
129
]
],
[
[
1056,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1056,
21,
28703
],
[
28703,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Telithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Telithromycin (Compound) causes Pruritus (Side Effec... |
DB01241 | DB08912 | 1,206 | 1,040 | [
"DDInter812",
"DDInter462"
] | Gemfibrozil | Dabrafenib | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1206,
24,
1040
]
],
[
[
1206,
6,
3486
],
[
3486,
45,
1040
]
],
[
[
1206,
18,
20057
],
[
20057,
57,
1040
]
],
[
[
1206,
7,
3586
],
[
35... | [
[
[
"Gemfibrozil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Gemfibrozil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)... | Gemfibrozil (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dabrafenib (Compound)
Gemfibrozil (Compound) downregulates SLC35F2 (Gene) and SLC35F2 (Gene) is downregulated by Dabrafenib (Compound)
Gemfibrozil (Compound) upregulates EZH2 (Gene) and EZH2 (Gene) is downregulated by Dabrafenib (Compound)
Gemfibr... |
DB08899 | DB14568 | 129 | 982 | [
"DDInter649",
"DDInter1000"
] | Enzalutamide | Ivosidenib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
129,
25,
982
]
],
[
[
129,
62,
271
],
[
271,
23,
982
]
],
[
[
129,
64,
168
],
[
168,
23,
982
]
],
[
[
129,
23,
1459
],
[
1459,
2... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Enzalutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegr... | Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Enzalutamide may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause ... |
DB00818 | DB09078 | 898 | 1,228 | [
"DDInter1538",
"DDInter1036"
] | Propofol | Lenvatinib | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
898,
24,
1228
]
],
[
[
898,
23,
112
],
[
112,
23,
1228
]
],
[
[
898,
24,
609
],
[
609,
24,
1228
]
],
[
[
898,
24,
603
],
[
603,
... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Propofol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Propofol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clar... |
DB00041 | DB14811 | 1,648 | 385 | [
"DDInter38",
"DDInter979"
] | Aldesleukin | Isatuximab | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
1648,
24,
385
]
],
[
[
1648,
24,
1362
],
[
1362,
24,
385
]
],
[
[
1648,
25,
611
],
[
611,
24,
385
]
],
[
[
1648,
63,
1257
],
[
1257,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Aldesleukin may lead to a major life threatening interaction when taken with Dacarbazine and Dacarbazine may cause ... |
DB05316 | DB09065 | 749 | 760 | [
"DDInter1467",
"DDInter424"
] | Pimavanserin | Cobicistat | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
749,
25,
760
]
],
[
[
749,
63,
1101
],
[
1101,
23,
760
]
],
[
[
749,
24,
1374
],
[
1374,
23,
760
]
],
[
[
749,
63,
723
],
[
723,
... | [
[
[
"Pimavanserin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abi... |
DB00812 | DB01250 | 998 | 712 | [
"DDInter1451",
"DDInter1334"
] | Phenylbutazone | Olsalazine | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
998,
24,
712
]
],
[
[
998,
63,
50
],
[
50,
40,
712
]
],
[
[
998,
6,
10522
],
[
10522,
45,
712
]
],
[
[
998,
64,
126
],
[
126,
23... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Phenylbutazone (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Olsalazine (Compound)
Phenylbutazone may lead to a major life threatening in... |
DB01030 | DB11988 | 869 | 270 | [
"DDInter1835",
"DDInter1321"
] | Topotecan | Ocrelizumab | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
869,
24,
270
]
],
[
[
869,
63,
1461
],
[
1461,
23,
270
]
],
[
[
869,
24,
1060
],
[
1060,
63,
270
]
],
[
[
869,
63,
134
],
[
134,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enf... |
DB00994 | DB01212 | 361 | 1,453 | [
"DDInter1277",
"DDInter334"
] | Neomycin | Ceftriaxone | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse ac... | Moderate | 1 | [
[
[
361,
24,
1453
]
],
[
[
361,
24,
1024
],
[
1024,
40,
1453
]
],
[
[
361,
63,
149
],
[
149,
40,
1453
]
],
[
[
361,
24,
1227
],
[
1227,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftriaxone"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
],
[
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefpodoxime and Cefpodoxime (Compound) resembles Ceftriaxone (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Ceftriaxone (Compound... |
DB00264 | DB00668 | 88 | 874 | [
"DDInter1200",
"DDInter652"
] | Metoprolol | Epinephrine | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
88,
24,
874
]
],
[
[
88,
24,
1636
],
[
1636,
1,
874
]
],
[
[
88,
24,
688
],
[
688,
63,
874
]
],
[
[
88,
6,
3576
],
[
3576,
45,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction tha... |
DB01234 | DB09098 | 1,220 | 98 | [
"DDInter513",
"DDInter1700"
] | Dexamethasone | Somatrem | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1220,
24,
98
]
],
[
[
1220,
23,
1612
],
[
1612,
62,
98
]
],
[
[
1220,
62,
608
],
[
608,
23,
98
]
],
[
[
1220,
23,
1459
],
[
1459,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Dexamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fostemsavir"
],
[... | Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Somatrem
Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocai... |
DB04953 | DB11837 | 495 | 1,297 | [
"DDInter708",
"DDInter1351"
] | Ezogabine | Osilodrostat | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
495,
24,
1297
]
],
[
[
495,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
495,
62,
112
],
[
112,
23,
1297
]
],
[
[
495,
63,
222
],
[
222,
... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Ezogabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Ezogabine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Ezogabine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazo... |
DB00163 | DB00620 | 1,461 | 175 | [
"DDInter1943",
"DDInter1855"
] | Vitamin E | Triamcinolone | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Minor | 0 | [
[
[
1461,
23,
175
]
],
[
[
1461,
23,
1573
],
[
1573,
1,
175
]
],
[
[
1461,
23,
617
],
[
617,
40,
175
]
],
[
[
1461,
24,
1018
],
[
1018,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Triamcinolone"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compound)
... |
DB00816 | DB01132 | 1,674 | 1,130 | [
"DDInter1346",
"DDInter1472"
] | Orciprenaline | Pioglitazone | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
1674,
24,
1130
]
],
[
[
1674,
21,
28778
],
[
28778,
60,
1130
]
],
[
[
1674,
63,
307
],
[
307,
23,
1130
]
],
[
[
1674,
24,
359
],
[
359... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Orciprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
... | Orciprenaline (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects w... |
DB00911 | DB09115 | 458 | 505 | [
"DDInter1811",
"DDInter559"
] | Tinidazole | Diiodohydroxyquinoline | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
458,
24,
505
]
],
[
[
458,
24,
1593
],
[
1593,
24,
505
]
],
[
[
458,
63,
467
],
[
467,
24,
505
]
],
[
[
458,
24,
1434
],
[
1434,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Simvastat... |
DB00710 | DB11248 | 1,199 | 1,193 | [
"DDInter897",
"DDInter1965"
] | Ibandronate | Zinc gluconate | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1199,
24,
1193
]
],
[
[
1199,
24,
1596
],
[
1596,
23,
1193
]
],
[
[
1199,
24,
428
],
[
428,
62,
1193
]
],
[
[
1199,
25,
629
],
[
629,
... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
[
... | Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous ... |
DB01023 | DB12267 | 409 | 1,476 | [
"DDInter716",
"DDInter233"
] | Felodipine | Brigatinib | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
409,
24,
1476
]
],
[
[
409,
23,
1135
],
[
1135,
23,
1476
]
],
[
[
409,
63,
629
],
[
629,
24,
1476
]
],
[
[
409,
24,
1531
],
[
1531,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Felodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Felodipine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may... |
DB11581 | DB11796 | 1,456 | 1,612 | [
"DDInter1926",
"DDInter786"
] | Venetoclax | Fostemsavir | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1456,
24,
1612
]
],
[
[
1456,
63,
1051
],
[
1051,
23,
1612
]
],
[
[
1456,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
1456,
64,
1220
],
[
12... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Brigatin... |
DB00916 | DB01357 | 112 | 890 | [
"DDInter1202",
"DDInter1160"
] | Metronidazole | Mestranol | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
112,
24,
890
]
],
[
[
112,
63,
1438
],
[
1438,
1,
890
]
],
[
[
112,
6,
6017
],
[
6017,
45,
890
]
],
[
[
112,
62,
752
],
[
752,
2... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Mestranol (Compound)
Metronidazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Mestranol (Compound)
Metronidazole may cause a minor interaction that can limit clini... |
DB00794 | DB11978 | 759 | 124 | [
"DDInter1521",
"DDInter822"
] | Primidone | Glasdegib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
759,
25,
124
]
],
[
[
759,
25,
1135
],
[
1135,
23,
124
]
],
[
[
759,
24,
112
],
[
112,
23,
124
]
],
[
[
759,
25,
466
],
[
466,
6... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ca... | Primidone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a... |
DB00014 | DB09564 | 521 | 1,296 | [
"DDInter839",
"DDInter930"
] | Goserelin | Insulin degludec | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
521,
24,
1296
]
],
[
[
521,
25,
17
],
[
17,
24,
1296
]
],
[
[
521,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
521,
24,
1385
],
[
1385,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotalol",... | Goserelin may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause ... |
DB00741 | DB11640 | 167 | 1,267 | [
"DDInter885",
"DDInter64"
] | Hydrocortisone | Amifampridine | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
167,
24,
1267
]
],
[
[
167,
1,
1220
],
[
1220,
24,
1267
]
],
[
[
167,
24,
913
],
[
913,
63,
1267
]
],
[
[
167,
40,
870
],
[
870,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
"{u} ma... | Hydrocortisone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate int... |
DB06723 | DB13257 | 115 | 260 | [
"DDInter58",
"DDInter727"
] | Aluminum hydroxide | Ferrous sulfate anhydrous | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
115,
24,
260
]
],
[
[
115,
62,
752
],
[
752,
23,
260
]
],
[
[
115,
63,
1096
],
[
1096,
23,
260
]
],
[
[
115,
63,
1620
],
[
1620,
... | [
[
[
"Aluminum hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Aluminum hydroxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
... | Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ferrous sulfate anhydrous
Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken... |
DB06605 | DB09075 | 1,409 | 498 | [
"DDInter108",
"DDInter621"
] | Apixaban | Edoxaban | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
1409,
25,
498
]
],
[
[
1409,
23,
944
],
[
944,
62,
498
]
],
[
[
1409,
24,
1004
],
[
1004,
63,
498
]
],
[
[
1409,
24,
41
],
[
41,
... | [
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Apixaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
"... | Apixaban may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl sali... |
DB06810 | DB15035 | 397 | 503 | [
"DDInter1484",
"DDInter1959"
] | Plicamycin | Zanubrutinib | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
397,
25,
503
]
],
[
[
397,
63,
222
],
[
222,
24,
503
]
],
[
[
397,
24,
810
],
[
810,
24,
503
]
],
[
[
397,
64,
39
],
[
39,
25,
... | [
[
[
"Plicamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutra... | Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chlorid... |
DB00584 | DB09038 | 610 | 1,450 | [
"DDInter638",
"DDInter636"
] | Enalapril | Empagliflozin | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
610,
24,
1450
]
],
[
[
610,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
610,
24,
1486
],
[
1486,
24,
1450
]
],
[
[
610,
1,
1603
],
[
1603,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolo... |
DB06723 | DB08912 | 115 | 1,040 | [
"DDInter58",
"DDInter462"
] | Aluminum hydroxide | Dabrafenib | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
115,
24,
1040
]
],
[
[
115,
21,
28882
],
[
28882,
60,
1040
]
],
[
[
115,
63,
478
],
[
478,
24,
1040
]
],
[
[
115,
62,
870
],
[
870,
... | [
[
[
"Aluminum hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Aluminum hydroxide",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temper... | Aluminum hydroxide (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dabrafenib (Compound)
Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that c... |
DB06210 | DB11652 | 72 | 1,155 | [
"DDInter631",
"DDInter1891"
] | Eltrombopag | Tucatinib | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
72,
24,
1155
]
],
[
[
72,
24,
1613
],
[
1613,
24,
1155
]
],
[
[
72,
63,
1419
],
[
1419,
24,
1155
]
],
[
[
72,
24,
466
],
[
466,
... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Tucatinib
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00877 | DB14409 | 629 | 1,129 | [
"DDInter1678",
"DDInter867"
] | Sirolimus | Human adenovirus e serotype 4 strain cl-68578 antigen | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
629,
24,
1129
]
],
[
[
629,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
629,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
629,
63,
134
],
[
134,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"E... | Sirolimus may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00501 | DB06616 | 752 | 594 | [
"DDInter380",
"DDInter224"
] | Cimetidine | Bosutinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
752,
24,
594
]
],
[
[
752,
63,
883
],
[
883,
1,
594
]
],
[
[
752,
6,
8374
],
[
8374,
45,
594
]
],
[
[
752,
18,
6351
],
[
6351,
5... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Cimetidine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is d... |
DB08897 | DB13913 | 1,429 | 1,536 | [
"DDInter22",
"DDInter175"
] | Aclidinium | Belladonna | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
1429,
24,
1536
]
],
[
[
1429,
63,
849
],
[
849,
24,
1536
]
],
[
[
1429,
24,
412
],
[
412,
24,
1536
]
],
[
[
1429,
74,
1415
],
[
1415,
... | [
[
[
"Aclidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Aclidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Aclidinium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Aclidinium may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline and Eluxa... |
DB00996 | DB01114 | 1,198 | 272 | [
"DDInter791",
"DDInter362"
] | Gabapentin | Chlorpheniramine | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1198,
24,
272
]
],
[
[
1198,
24,
849
],
[
849,
63,
272
]
],
[
[
1198,
63,
128
],
[
128,
24,
272
]
],
[
[
1198,
21,
28705
],
[
28705,
... | [
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00188 | DB11827 | 168 | 433 | [
"DDInter222",
"DDInter669"
] | Bortezomib | Ertugliflozin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
168,
24,
433
]
],
[
[
168,
23,
1654
],
[
1654,
63,
433
]
],
[
[
168,
25,
695
],
[
695,
24,
433
]
],
[
[
168,
24,
959
],
[
959,
2... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Somapacitan"
],
[
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan and Somapacitan may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Bortezomib may lead to a major life threatening interaction when taken with Clozapine and Clozapine may cause... |
DB11110 | DB13997 | 603 | 133 | [
"DDInter1115",
"DDInter163"
] | Magnesium citrate | Baloxavir marboxil | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of [baloxavir] with an improved absorption profile than its active metabolite due to the add... | Moderate | 1 | [
[
[
603,
24,
133
]
],
[
[
603,
63,
853
],
[
853,
24,
133
]
],
[
[
603,
63,
853
],
[
853,
63,
544
],
[
544,
24,
133
]
],
[
[
603,
63,... | [
[
[
"Magnesium citrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baloxavir marboxil"
]
],
[
[
"Magnesium citrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magne... | Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride and Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Baloxavir marboxil
Magnesium citrate may cause a moderate interaction that could exacerbate diseases... |
DB01210 | DB06703 | 668 | 619 | [
"DDInter1050",
"DDInter793"
] | Levobunolol (ophthalmic) | Gadobutrol | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to ot... | Moderate | 1 | [
[
[
668,
24,
619
]
],
[
[
668,
21,
28809
],
[
28809,
60,
619
]
],
[
[
668,
24,
1013
],
[
1013,
63,
619
]
],
[
[
668,
40,
461
],
[
461,
... | [
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobutrol"
]
],
[
[
"Levobunolol",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is ca... | Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Gadobutrol
Levobunolol (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Gadobutrol (Compound)
Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Tyropano... |
DB00627 | DB01132 | 265 | 1,130 | [
"DDInter1286",
"DDInter1472"
] | Niacin | Pioglitazone | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
265,
24,
1130
]
],
[
[
265,
6,
12523
],
[
12523,
45,
1130
]
],
[
[
265,
21,
28778
],
[
28778,
60,
1130
]
],
[
[
265,
63,
305
],
[
305,... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Niacin",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Niacin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pioglitazone (Compound)
Niacin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound)
Niacin may cause a moderate interaction that could exacerbate diseases when taken with Asparagin... |
DB00881 | DB01377 | 954 | 1,283 | [
"DDInter1554",
"DDInter1119"
] | Quinapril | Magnesium oxide | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
954,
23,
1283
]
],
[
[
954,
40,
743
],
[
743,
23,
1283
]
],
[
[
954,
63,
167
],
[
167,
23,
1283
]
],
[
[
954,
1,
1523
],
[
1523,
... | [
[
[
"Quinapril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Quinapril",
"{u} (Compound) resembles {v} (Compound)",
"Lisinopril"
],
[
"Lisinopril",
"{u} may cause a minor ... | Quinapril (Compound) resembles Lisinopril (Compound) and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that... |
DB00635 | DB01193 | 1,573 | 819 | [
"DDInter1515",
"DDInter12"
] | Prednisone | Acebutolol | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1573,
24,
819
]
],
[
[
1573,
24,
887
],
[
887,
1,
819
]
],
[
[
1573,
63,
1121
],
[
1121,
1,
819
]
],
[
[
1573,
6,
4973
],
[
4973,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Acebutolol (Compound)
Pred... |
DB01064 | DB01259 | 1,148 | 392 | [
"DDInter987",
"DDInter1024"
] | Isoprenaline | Lapatinib | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1148,
24,
392
]
],
[
[
1148,
21,
28695
],
[
28695,
60,
392
]
],
[
[
1148,
63,
898
],
[
898,
24,
392
]
],
[
[
1148,
24,
749
],
[
749,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Isoprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspnoea"
],
[
"Dyspnoea",
"{u} (Side Effect) is cau... | Isoprenaline (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Lapatinib (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Propofol and Propofol may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib
... |
DB00595 | DB09564 | 1,545 | 1,296 | [
"DDInter1374",
"DDInter930"
] | Oxytetracycline | Insulin degludec | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1545,
24,
1296
]
],
[
[
1545,
62,
811
],
[
811,
24,
1296
]
],
[
[
1545,
40,
964
],
[
964,
24,
1296
]
],
[
[
1545,
63,
305
],
[
305,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Oxytetracycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate intera... |
DB00388 | DB01064 | 1,636 | 1,148 | [
"DDInter1453",
"DDInter987"
] | Phenylephrine | Isoprenaline | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1636,
24,
1148
]
],
[
[
1636,
24,
480
],
[
480,
24,
1148
]
],
[
[
1636,
1,
874
],
[
874,
24,
1148
]
],
[
[
1636,
24,
1551
],
[
1551,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Phenylephrine (Compound) resembles Epinephrine (Compound) and Epinephrine may cause a moderate interaction ... |
DB11767 | DB14881 | 1,583 | 180 | [
"DDInter1643",
"DDInter1329"
] | Sarilumab | Oliceridine | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
1583,
24,
180
]
],
[
[
1583,
64,
1184
],
[
1184,
24,
180
]
],
[
[
1583,
63,
58
],
[
58,
24,
180
]
],
[
[
1583,
25,
1259
],
[
1259,
... | [
[
[
"Sarilumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Sarilumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anakinra"
],
[
"Anakinra",
... | Sarilumab may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Sarilumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moder... |
DB01076 | DB09104 | 700 | 286 | [
"DDInter133",
"DDInter1118"
] | Atorvastatin | Magnesium hydroxide | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
700,
23,
286
]
],
[
[
700,
63,
752
],
[
752,
23,
286
]
],
[
[
700,
24,
1468
],
[
1468,
23,
286
]
],
[
[
700,
24,
1593
],
[
1593,
... | [
[
[
"Atorvastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib ... |
DB00083 | DB00804 | 677 | 1,507 | [
"DDInter225",
"DDInter543"
] | Botulinum toxin type A | Dicyclomine | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
677,
24,
1507
]
],
[
[
677,
24,
1594
],
[
1594,
24,
1507
]
],
[
[
677,
24,
100
],
[
100,
63,
1507
]
],
[
[
677,
24,
1594
],
[
1594,
... | [
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Do... | Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine
Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00215 | DB08875 | 1,230 | 1,618 | [
"DDInter388",
"DDInter262"
] | Citalopram | Cabozantinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1230,
25,
1618
]
],
[
[
1230,
23,
112
],
[
112,
23,
1618
]
],
[
[
1230,
23,
723
],
[
723,
24,
1618
]
],
[
[
1230,
23,
384
],
[
384,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Citalopram may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Apre... |
DB01276 | DB09082 | 123 | 659 | [
"DDInter706",
"DDInter1934"
] | Exenatide | Vilanterol | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
123,
24,
659
]
],
[
[
123,
63,
1220
],
[
1220,
23,
659
]
],
[
[
123,
24,
708
],
[
708,
23,
659
]
],
[
[
123,
24,
1296
],
[
1296,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and C... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.