drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB08903 | DB09020 | 996 | 28 | [
"DDInter170",
"DDInter212"
] | Bedaquiline | Bisacodyl | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
996,
24,
28
]
],
[
[
996,
21,
28666
],
[
28666,
60,
28
]
],
[
[
996,
25,
823
],
[
823,
63,
28
]
],
[
[
996,
64,
1250
],
[
1250,
... | [
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Bedaquiline",
"{u} (Compound) causes {v} (Side Effect)",
"Nervous system disorder"
],
[
"Nervous system disorder",
... | Bedaquiline (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Bedaquiline may lead to a major life threatening interaction when taken with Triclabendazole and Triclabendazole may cause a moderate interaction that could exacerbate diseases... |
DB00446 | DB12267 | 597 | 1,476 | [
"DDInter351",
"DDInter233"
] | Chloramphenicol | Brigatinib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
597,
25,
1476
]
],
[
[
597,
25,
1135
],
[
1135,
23,
1476
]
],
[
[
597,
63,
168
],
[
168,
23,
1476
]
],
[
[
597,
24,
629
],
[
629,
... | [
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Chloramphenicol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may ... |
DB00398 | DB00557 | 79 | 252 | [
"DDInter1702",
"DDInter895"
] | Sorafenib | Hydroxyzine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Moderate | 1 | [
[
[
79,
24,
252
]
],
[
[
79,
24,
1630
],
[
1630,
1,
252
]
],
[
[
79,
24,
623
],
[
623,
40,
252
]
],
[
[
79,
6,
12523
],
[
12523,
45,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Hydroxyzine (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Hydroxyzine (Compou... |
DB00197 | DB09570 | 1,324 | 1,480 | [
"DDInter1881",
"DDInter1002"
] | Troglitazone | Ixazomib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1324,
24,
1480
]
],
[
[
1324,
24,
152
],
[
152,
24,
1480
]
],
[
[
1324,
24,
1598
],
[
1598,
63,
1480
]
],
[
[
1324,
63,
912
],
[
912,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bosentan and Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Tazeme... |
DB00281 | DB01203 | 608 | 699 | [
"DDInter1066",
"DDInter1255"
] | Lidocaine | Nadolol | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
608,
24,
699
]
],
[
[
608,
24,
729
],
[
729,
1,
699
]
],
[
[
608,
6,
4973
],
[
4973,
45,
699
]
],
[
[
608,
21,
29868
],
[
29868,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
[
"... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Lidocaine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nadolol (Compound)
Lidocaine (Compound) causes Slurred speech (Side Effect) and Slurred speech ... |
DB00014 | DB00526 | 521 | 1,555 | [
"DDInter839",
"DDInter1355"
] | Goserelin | Oxaliplatin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
521,
24,
1555
]
],
[
[
521,
23,
1247
],
[
1247,
62,
1555
]
],
[
[
521,
24,
79
],
[
79,
24,
1555
]
],
[
[
521,
24,
1232
],
[
1232,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Oxaliplatin
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and ... |
DB08826 | DB09276 | 1,292 | 381 | [
"DDInter489",
"DDInter1682"
] | Deferiprone | Sodium aurothiomalate | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Major | 2 | [
[
[
1292,
25,
381
]
],
[
[
1292,
64,
491
],
[
491,
24,
381
]
],
[
[
1292,
25,
1593
],
[
1593,
24,
381
]
],
[
[
1292,
25,
1480
],
[
1480,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon alfa-2a"
],
[
"P... | Deferiprone may lead to a major life threatening interaction when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Deferiprone may lead to a major life threatening interaction when taken with Crizotinib and C... |
DB00262 | DB05679 | 552 | 1,683 | [
"DDInter302",
"DDInter1907"
] | Carmustine | Ustekinumab | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
552,
24,
1683
]
],
[
[
552,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
552,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
552,
63,
305
],
[
305,
... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib ma... |
DB00983 | DB01001 | 480 | 688 | [
"DDInter776",
"DDInter1632"
] | Formoterol | Salbutamol | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
480,
24,
688
]
],
[
[
480,
63,
874
],
[
874,
24,
688
]
],
[
[
480,
25,
668
],
[
668,
64,
688
]
],
[
[
480,
24,
1148
],
[
1148,
6... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Formoterol may lead to a major life threatening interaction when taken with Levobunolol and Levobunolol may le... |
DB00365 | DB01132 | 839 | 1,130 | [
"DDInter842",
"DDInter1472"
] | Grepafloxacin | Pioglitazone | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
839,
24,
1130
]
],
[
[
839,
24,
303
],
[
303,
23,
1130
]
],
[
[
839,
24,
688
],
[
688,
24,
1130
]
],
[
[
839,
25,
11
],
[
11,
24... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Pioglitazone
Grepafloxacin may cause a moderate interaction that could exacerbate diseas... |
DB00973 | DB09272 | 1,149 | 412 | [
"DDInter707",
"DDInter632"
] | Ezetimibe | Eluxadoline | Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it was being localized within enterocytes of the intestinal vill... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1149,
24,
412
]
],
[
[
1149,
63,
467
],
[
467,
24,
412
]
],
[
[
1149,
24,
14
],
[
14,
24,
412
]
],
[
[
1149,
1,
1568
],
[
1568,
... | [
[
[
"Ezetimibe",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Ezetimibe",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Ezetimibe may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Ezetimibe may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Ros... |
DB01075 | DB09291 | 1,376 | 741 | [
"DDInter569",
"DDInter1615"
] | Diphenhydramine | Rolapitant | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1376,
24,
741
]
],
[
[
1376,
63,
211
],
[
211,
23,
741
]
],
[
[
1376,
63,
506
],
[
506,
24,
741
]
],
[
[
1376,
24,
924
],
[
924,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Rolapitant
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dextrometho... |
DB00220 | DB12332 | 798 | 1,619 | [
"DDInter1276",
"DDInter1626"
] | Nelfinavir | Rucaparib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
798,
24,
1619
]
],
[
[
798,
23,
222
],
[
222,
23,
1619
]
],
[
[
798,
25,
1135
],
[
1135,
23,
1619
]
],
[
[
798,
24,
309
],
[
309,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Nelfinavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Nelfinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a min... |
DB00284 | DB01234 | 1,647 | 1,220 | [
"DDInter11",
"DDInter513"
] | Acarbose | Dexamethasone | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1647,
24,
1220
]
],
[
[
1647,
24,
870
],
[
870,
1,
1220
]
],
[
[
1647,
24,
175
],
[
175,
40,
1220
]
],
[
[
1647,
23,
1103
],
[
1103,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamet... |
DB04865 | DB06043 | 4 | 1,644 | [
"DDInter1335",
"DDInter1328"
] | Omacetaxine mepesuccinate | Olaratumab | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Moderate | 1 | [
[
[
4,
24,
1644
]
],
[
[
4,
24,
1531
],
[
1531,
63,
1644
]
],
[
[
4,
63,
1184
],
[
1184,
24,
1644
]
],
[
[
4,
24,
1683
],
[
1683,
24... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaratumab"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaratumab
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when ... |
DB00658 | DB01070 | 965 | 1,098 | [
"DDInter1663",
"DDInter558"
] | Sevelamer | Dihydrotachysterol | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
965,
24,
1098
]
],
[
[
965,
63,
386
],
[
386,
25,
1098
]
],
[
[
965,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
965,
24,
1196
],
[
1196,
... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol and Par... |
DB00465 | DB01082 | 886 | 1,448 | [
"DDInter1010",
"DDInter1713"
] | Ketorolac | Streptomycin | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
886,
24,
1448
]
],
[
[
886,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
886,
24,
1272
],
[
1272,
63,
1448
]
],
[
[
886,
24,
91
],
[
91,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Ketorolac",
"{u} (Compound) causes {v} (Side Effect)",
"Renal failure"
],
[
"Renal failure",
"{u} (Side Effect)... | Ketorolac (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00321 | DB00668 | 21 | 874 | [
"DDInter78",
"DDInter652"
] | Amitriptyline | Epinephrine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Major | 2 | [
[
[
21,
25,
874
]
],
[
[
21,
25,
1636
],
[
1636,
1,
874
]
],
[
[
21,
24,
688
],
[
688,
63,
874
]
],
[
[
21,
6,
7950
],
[
7950,
45,
... | [
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylephrine"
],
[
"Phenylephrine",... | Amitriptyline may lead to a major life threatening interaction when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could e... |
DB06203 | DB06791 | 1,002 | 1,446 | [
"DDInter51",
"DDInter1021"
] | Alogliptin | Lanreotide | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
1002,
24,
1446
]
],
[
[
1002,
24,
154
],
[
154,
63,
1446
]
],
[
[
1002,
63,
1685
],
[
1685,
24,
1446
]
],
[
[
1002,
1,
1281
],
[
1281,... | [
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
... | Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Ins... |
DB01182 | DB14724 | 371 | 48 | [
"DDInter1534",
"DDInter634"
] | Propafenone | Emapalumab | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
371,
24,
48
]
],
[
[
371,
25,
1456
],
[
1456,
24,
48
]
],
[
[
371,
63,
126
],
[
126,
24,
48
]
],
[
[
371,
24,
1409
],
[
1409,
24... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Propafenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
],
[
"Venetocl... | Propafenone may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a ... |
DB00990 | DB12825 | 1,547 | 1,375 | [
"DDInter705",
"DDInter1032"
] | Exemestane | Lefamulin | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1547,
24,
1375
]
],
[
[
1547,
63,
1101
],
[
1101,
24,
1375
]
],
[
[
1547,
24,
98
],
[
98,
24,
1375
]
],
[
[
1547,
25,
770
],
[
770,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem ... |
DB00029 | DB00991 | 25 | 97 | [
"DDInter99",
"DDInter1358"
] | Anistreplase | Oxaprozin | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
25,
24,
97
]
],
[
[
25,
24,
1274
],
[
1274,
24,
97
]
],
[
[
25,
25,
936
],
[
936,
63,
97
]
],
[
[
25,
64,
1578
],
[
1578,
24,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Anistreplase may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may c... |
DB00762 | DB12893 | 613 | 586 | [
"DDInter973",
"DDInter1629"
] | Irinotecan | Sacituzumab govitecan | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab goviteca... | Major | 2 | [
[
[
613,
25,
586
]
],
[
[
613,
24,
270
],
[
270,
24,
586
]
],
[
[
613,
63,
58
],
[
58,
24,
586
]
],
[
[
613,
25,
384
],
[
384,
24,
... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sacituzumab govitecan"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sacituzumab govitecan
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Alefacep... |
DB00224 | DB00673 | 215 | 723 | [
"DDInter917",
"DDInter112"
] | Indinavir | Aprepitant | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
215,
24,
723
]
],
[
[
215,
6,
6799
],
[
6799,
45,
723
]
],
[
[
215,
21,
28890
],
[
28890,
60,
723
]
],
[
[
215,
23,
222
],
[
222,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Indinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compound)",
... | Indinavir (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Aprepitant (Compound)
Indinavir (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Aprepitant (Compound)
Indinavir may cause a minor interaction that can limit clinical effects when taken with ... |
DB01181 | DB14811 | 1,532 | 385 | [
"DDInter906",
"DDInter979"
] | Ifosfamide | Isatuximab | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
1532,
24,
385
]
],
[
[
1532,
24,
1362
],
[
1362,
24,
385
]
],
[
[
1532,
63,
377
],
[
377,
24,
385
]
],
[
[
1532,
74,
450
],
[
450,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin m... |
DB00889 | DB06448 | 1,133 | 171 | [
"DDInter840",
"DDInter1087"
] | Granisetron | Lonafarnib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
1133,
24,
171
]
],
[
[
1133,
25,
222
],
[
222,
23,
171
]
],
[
[
1133,
63,
888
],
[
888,
24,
171
]
],
[
[
1133,
23,
112
],
[
112,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutra... | Granisetron may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Lonafarnib
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause ... |
DB01211 | DB06603 | 609 | 39 | [
"DDInter393",
"DDInter1387"
] | Clarithromycin | Panobinostat | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
609,
25,
39
]
],
[
[
609,
62,
1247
],
[
1247,
23,
39
]
],
[
[
609,
63,
211
],
[
211,
23,
39
]
],
[
[
609,
63,
912
],
[
912,
24,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Tol... |
DB00945 | DB01124 | 1,479 | 1,411 | [
"DDInter20",
"DDInter1828"
] | Acetylsalicylic acid | Tolbutamide | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1479,
24,
1411
]
],
[
[
1479,
24,
959
],
[
959,
40,
1411
]
],
[
[
1479,
24,
824
],
[
824,
24,
1411
]
],
[
[
1479,
63,
245
],
[
245,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipiz... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Probenecid and Probenecid may cause a moderate int... |
DB01197 | DB01222 | 1,603 | 617 | [
"DDInter292",
"DDInter246"
] | Captopril | Budesonide | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
1603,
24,
617
]
],
[
[
1603,
63,
251
],
[
251,
1,
617
]
],
[
[
1603,
24,
1220
],
[
1220,
1,
617
]
],
[
[
1603,
18,
10351
],
[
10351,
... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Budesonide (... |
DB00581 | DB09268 | 355 | 1,662 | [
"DDInter1018",
"DDInter1464"
] | Lactulose | Picosulfuric acid | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
355,
24,
1662
]
],
[
[
355,
24,
721
],
[
721,
62,
1662
]
],
[
[
355,
23,
16
],
[
16,
23,
1662
]
],
[
[
355,
24,
484
],
[
484,
63... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylcellulose"
]... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Methylcellulose and Methylcellulose may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Lactulose may cause a minor interaction that can limit clinical effects when taken with Linaclotid... |
DB00404 | DB09085 | 523 | 587 | [
"DDInter54",
"DDInter1779"
] | Alprazolam | Tetracaine | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch. | Moderate | 1 | [
[
[
523,
24,
587
]
],
[
[
523,
1,
686
],
[
686,
24,
587
]
],
[
[
523,
40,
1119
],
[
1119,
24,
587
]
],
[
[
523,
1,
686
],
[
686,
1,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracaine"
]
],
[
[
"Alprazolam",
"{u} (Compound) resembles {v} (Compound)",
"Oxazepam"
],
[
"Oxazepam",
"{u} may cause a moderate in... | Alprazolam (Compound) resembles Oxazepam (Compound) and Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Tetracaine
Alprazolam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Tet... |
DB00649 | DB01229 | 231 | 973 | [
"DDInter1710",
"DDInter1378"
] | Stavudine | Paclitaxel (protein-bound) | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
231,
24,
973
]
],
[
[
231,
24,
310
],
[
310,
63,
973
]
],
[
[
231,
7,
9489
],
[
9489,
46,
973
]
],
[
[
231,
21,
28779
],
[
28779,
... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Stavudine ... |
DB01024 | DB01333 | 1,096 | 207 | [
"DDInter1252",
"DDInter328"
] | Mycophenolic acid | Cefradine | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | A semi-synthetic cephalosporin antibiotic. | Moderate | 1 | [
[
[
1096,
24,
207
]
],
[
[
1096,
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],
[
315,
40,
207
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[
[
1096,
63,
778
],
[
778,
1,
207
]
],
[
[
1096,
24,
1227
],
[
1227,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefradine"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefprozil"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefprozil and Cefprozil (Compound) resembles Cefradine (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefixime and Cefixime (Compound) resembles Cefradine (Comp... |
DB00313 | DB00514 | 556 | 506 | [
"DDInter1913",
"DDInter527"
] | Valproic acid | Dextromethorphan | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
556,
24,
506
]
],
[
[
556,
6,
8374
],
[
8374,
45,
506
]
],
[
[
556,
21,
28750
],
[
28750,
60,
506
]
],
[
[
556,
24,
13
],
[
13,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} ... | Valproic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Valproic acid (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Dextromethorphan (Compound)
Valproic acid may cause a moderate interaction that could exacerbate d... |
DB01367 | DB06704 | 1,163 | 247 | [
"DDInter1572",
"DDInter952"
] | Rasagiline | Iobenguane (I-131) | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
1163,
25,
247
]
],
[
[
1163,
21,
28787
],
[
28787,
60,
247
]
],
[
[
1163,
63,
820
],
[
820,
24,
247
]
],
[
[
1163,
24,
1090
],
[
1090,... | [
[
[
"Rasagiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Rasagiline",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (Co... | Rasagiline may lead to a major life threatening interaction when taken with Iobenguane
Rasagiline (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemaz... |
DB00060 | DB01095 | 912 | 671 | [
"DDInter947",
"DDInter769"
] | Interferon beta-1a | Fluvastatin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
912,
24,
671
]
],
[
[
912,
24,
788
],
[
788,
40,
671
]
],
[
[
912,
24,
14
],
[
14,
63,
671
]
],
[
[
912,
24,
126
],
[
126,
23,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastat... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a modera... |
DB01124 | DB01276 | 1,411 | 123 | [
"DDInter1828",
"DDInter706"
] | Tolbutamide | Exenatide | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1411,
24,
123
]
],
[
[
1411,
62,
1103
],
[
1103,
23,
123
]
],
[
[
1411,
63,
532
],
[
532,
24,
123
]
],
[
[
1411,
24,
1518
],
[
1518,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Exenatide
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamin... |
DB00397 | DB00574 | 1,466 | 121 | [
"DDInter1458",
"DDInter717"
] | Phenylpropanolamine | Fenfluramine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Major | 2 | [
[
[
1466,
25,
121
]
],
[
[
1466,
24,
1144
],
[
1144,
63,
121
]
],
[
[
1466,
24,
127
],
[
127,
24,
121
]
],
[
[
1466,
63,
831
],
[
831,
... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00363 | DB08882 | 695 | 1,281 | [
"DDInter419",
"DDInter1070"
] | Clozapine | Linagliptin | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
695,
24,
1281
]
],
[
[
695,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
695,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
695,
1,
623
],
[
623,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Clozapine (Compound) resembles Quetiapine (Compound) and Quetiapin... |
DB09074 | DB15719 | 1,362 | 487 | [
"DDInter1327",
"DDInter171"
] | Olaparib | Belantamab mafodotin | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
1362,
24,
487
]
],
[
[
1362,
63,
440
],
[
440,
24,
487
]
],
[
[
1362,
24,
810
],
[
810,
24,
487
]
],
[
[
1362,
64,
976
],
[
976,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrastim"
],
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim and Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Strontium chlor... |
DB00163 | DB00278 | 1,461 | 291 | [
"DDInter1943",
"DDInter117"
] | Vitamin E | Argatroban | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Moderate | 1 | [
[
[
1461,
24,
291
]
],
[
[
1461,
24,
578
],
[
578,
63,
291
]
],
[
[
1461,
24,
707
],
[
707,
64,
291
]
],
[
[
1461,
63,
1432
],
[
1432,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Argatroban"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Argatroban
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid and Danaparo... |
DB01136 | DB04843 | 772 | 1,511 | [
"DDInter305",
"DDInter1149"
] | Carvedilol | Mepenzolate | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
772,
24,
1511
]
],
[
[
772,
63,
1192
],
[
1192,
24,
1511
]
],
[
[
772,
21,
28975
],
[
28975,
60,
1511
]
],
[
[
772,
24,
849
],
[
849,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Carvedilol (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Mepenzolate (... |
DB00283 | DB00372 | 701 | 999 | [
"DDInter395",
"DDInter1793"
] | Clemastine | Thiethylperazine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
701,
24,
999
]
],
[
[
701,
63,
784
],
[
784,
24,
999
]
],
[
[
701,
24,
1614
],
[
1614,
63,
999
]
],
[
[
701,
24,
1089
],
[
1089,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pregabalin"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Pregabalin and Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Na... |
DB01563 | DB11130 | 680 | 407 | [
"DDInter349",
"DDInter1344"
] | Chloral hydrate | Opium | A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
680,
24,
407
]
],
[
[
680,
63,
662
],
[
662,
24,
407
]
],
[
[
680,
24,
849
],
[
849,
24,
407
]
],
[
[
680,
64,
475
],
[
475,
24,... | [
[
[
"Chloral hydrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Chloral hydrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Chloral hydrate may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Chloral hydrate may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine... |
DB00208 | DB12500 | 1,018 | 283 | [
"DDInter1804",
"DDInter714"
] | Ticlopidine | Fedratinib | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1018,
24,
283
]
],
[
[
1018,
23,
479
],
[
479,
23,
283
]
],
[
[
1018,
23,
211
],
[
211,
24,
283
]
],
[
[
1018,
24,
1580
],
[
1580,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
... | Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine... |
DB00420 | DB06176 | 508 | 1,342 | [
"DDInter1532",
"DDInter1616"
] | Promazine | Romidepsin | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
508,
24,
1342
]
],
[
[
508,
23,
112
],
[
112,
23,
1342
]
],
[
[
508,
24,
485
],
[
485,
24,
1342
]
],
[
[
508,
24,
1616
],
[
1616,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Promazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Promazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Penta... |
DB00279 | DB00344 | 1,152 | 1,302 | [
"DDInter1074",
"DDInter1543"
] | Liothyronine | Protriptyline | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Moderate | 1 | [
[
[
1152,
24,
1302
]
],
[
[
1152,
24,
1236
],
[
1236,
1,
1302
]
],
[
[
1152,
6,
4973
],
[
4973,
45,
1302
]
],
[
[
1152,
21,
28766
],
[
287... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Protriptyline (Compound)
Liothyronine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Protriptyline (Compound)
Liothyronine (Compound) causes Hypotension (Side Eff... |
DB00586 | DB12015 | 1,512 | 1,033 | [
"DDInter537",
"DDInter53"
] | Diclofenac | Alpelisib | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1512,
24,
1033
]
],
[
[
1512,
24,
738
],
[
738,
24,
1033
]
],
[
[
1512,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
1512,
63,
758
],
[
758,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Diclofenac may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cau... |
DB00215 | DB11978 | 1,230 | 124 | [
"DDInter388",
"DDInter822"
] | Citalopram | Glasdegib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1230,
25,
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],
[
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[
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[
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[
475,
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],
[
[
1230,
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[
79,
2... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphin... |
DB00827 | DB01206 | 646 | 37 | [
"DDInter383",
"DDInter1086"
] | Cinoxacin | Lomustine | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Minor | 0 | [
[
[
646,
23,
37
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[
[
646,
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[
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646,
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[
147,
23,
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],
[
[
646,
62,
141
],
[
141,
24... | [
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomustine"
]
],
[
[
"Cinoxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (... | Cinoxacin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound)
Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Lomustine
Cinoxaci... |
DB00222 | DB01238 | 245 | 673 | [
"DDInter825",
"DDInter118"
] | Glimepiride | Aripiprazole | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
245,
24,
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[
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[
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[
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28792
],
[
28792,
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673
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],
[
[
245,
64,
600
],
[
600,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compound)
Glimepiride (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Aripiprazole (Compound)
Gl... |
DB00349 | DB01041 | 902 | 770 | [
"DDInter401",
"DDInter1789"
] | Clobazam | Thalidomide | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
902,
24,
770
]
],
[
[
902,
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[
10215,
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[
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902,
21,
29177
],
[
29177,
60,
770
]
],
[
[
902,
24,
609
],
[
609,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Clobazam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Clobazam (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Thalidomide (Compound)
Clobazam (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)
Clobazam may cause a moderate interaction that could exacerbate diseases when ... |
DB00418 | DB01176 | 536 | 537 | [
"DDInter1650",
"DDInter453"
] | Secobarbital | Cyclizine | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
536,
24,
537
]
],
[
[
536,
63,
1242
],
[
1242,
24,
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]
],
[
[
536,
24,
104
],
[
104,
1,
537
]
],
[
[
536,
24,
13
],
[
13,
24,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and M... |
DB01155 | DB06788 | 872 | 1,616 | [
"DDInter813",
"DDInter864"
] | Gemifloxacin | Histrelin | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
872,
24,
1616
]
],
[
[
872,
62,
112
],
[
112,
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[
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872,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
872,
64,
1179
],
[
1179,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Gemifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and R... |
DB00675 | DB11652 | 888 | 1,155 | [
"DDInter1744",
"DDInter1891"
] | Tamoxifen | Tucatinib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
888,
24,
1155
]
],
[
[
888,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
888,
63,
1424
],
[
1424,
24,
1155
]
],
[
[
888,
24,
659
],
[
659,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may ca... |
DB00341 | DB00575 | 1,242 | 1,020 | [
"DDInter343",
"DDInter412"
] | Cetirizine | Clonidine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Moderate | 1 | [
[
[
1242,
24,
1020
]
],
[
[
1242,
24,
1617
],
[
1617,
40,
1020
]
],
[
[
1242,
21,
28810
],
[
28810,
60,
1020
]
],
[
[
1242,
24,
1311
],
[
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Clonidine (Compound)
Cetirizine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Clonidine (Compound)
Cetirizine may c... |
DB00015 | DB01242 | 582 | 1,237 | [
"DDInter1585",
"DDInter410"
] | Reteplase | Clomipramine | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
582,
24,
1237
]
],
[
[
582,
64,
1578
],
[
1578,
24,
1237
]
],
[
[
582,
24,
1274
],
[
1274,
24,
1237
]
],
[
[
582,
25,
498
],
[
498,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",... | Reteplase may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may caus... |
DB00431 | DB09268 | 1,503 | 1,662 | [
"DDInter1072",
"DDInter1464"
] | Lindane | Picosulfuric acid | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1503,
24,
1662
]
],
[
[
1503,
24,
1164
],
[
1164,
24,
1662
]
],
[
[
1503,
63,
342
],
[
342,
24,
1662
]
],
[
[
1503,
24,
163
],
[
163,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
],
[... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Interferon gamma... |
DB04868 | DB06663 | 478 | 1,154 | [
"DDInter1293",
"DDInter1398"
] | Nilotinib | Pasireotide | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
478,
25,
1154
]
],
[
[
478,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
478,
62,
112
],
[
112,
23,
1154
]
],
[
[
478,
23,
907
],
[
907,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Nilotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused by ... | Nilotinib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Nilotinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB08870 | DB14443 | 850 | 987 | [
"DDInter228",
"DDInter1931"
] | Brentuximab vedotin | Vibrio cholerae CVD 103-HgR strain live antigen | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
850,
24,
987
]
],
[
[
850,
24,
1480
],
[
1480,
24,
987
]
],
[
[
850,
63,
1488
],
[
1488,
24,
987
]
],
[
[
850,
64,
581
],
[
581,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases w... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Brentuximab vedotin may cause a moderate interaction that could exacer... |
DB00366 | DB00924 | 1,594 | 1,405 | [
"DDInter600",
"DDInter454"
] | Doxylamine | Cyclobenzaprine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
1594,
35,
1405
]
],
[
[
1594,
24,
649
],
[
649,
63,
1405
]
],
[
[
1594,
40,
11296
],
[
11296,
1,
1405
]
],
[
[
1594,
1,
293
],
[
293,
... | [
[
[
"Doxylamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when ta... | Doxylamine (Compound) resembles Cyclobenzaprine (Compound) and
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine
Doxylamine (Compound) resembles Bromodiphenh... |
DB00650 | DB08898 | 1,147 | 524 | [
"DDInter1041",
"DDInter828"
] | Leucovorin | Glucarpidase | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Glucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified _Escherichia coli_ bacteria. It is a 390-amino acid homodimer protein. High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades in treating various cancers; however, even with aggressive hydration, ... | Moderate | 1 | [
[
[
1147,
24,
524
]
],
[
[
1147,
64,
1548
],
[
1548,
24,
524
]
],
[
[
1147,
21,
28703
],
[
28703,
60,
304
],
[
304,
24,
524
]
],
[
[
1147,... | [
[
[
"Leucovorin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glucarpidase"
]
],
[
[
"Leucovorin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimethoprim"
],
[
"Trimet... | Leucovorin may lead to a major life threatening interaction when taken with Trimethoprim and Trimethoprim may cause a moderate interaction that could exacerbate diseases when taken with Glucarpidase
Leucovorin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Trimetrexate (Compound) and T... |
DB00333 | DB00877 | 576 | 629 | [
"DDInter1166",
"DDInter1678"
] | Methadone | Sirolimus | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
576,
24,
629
]
],
[
[
576,
6,
4973
],
[
4973,
45,
629
]
],
[
[
576,
21,
28898
],
[
28898,
60,
629
]
],
[
[
576,
24,
1476
],
[
1476,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Methadone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Methadone (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Sirolimus (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB09078 | DB13074 | 1,228 | 877 | [
"DDInter1036",
"DDInter1110"
] | Lenvatinib | Macimorelin | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1228,
25,
877
]
],
[
[
1228,
62,
112
],
[
112,
23,
877
]
],
[
[
1228,
63,
673
],
[
673,
24,
877
]
],
[
[
1228,
24,
913
],
[
913,
... | [
[
[
"Lenvatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Lenvatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Lenvatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and A... |
DB01075 | DB09237 | 1,376 | 1,586 | [
"DDInter569",
"DDInter1045"
] | Diphenhydramine | Levamlodipine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1376,
24,
1586
]
],
[
[
1376,
63,
1648
],
[
1648,
24,
1586
]
],
[
[
1376,
24,
478
],
[
478,
24,
1586
]
],
[
[
1376,
24,
283
],
[
283,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Niloti... |
DB00682 | DB01329 | 126 | 1,458 | [
"DDInter1951",
"DDInter322"
] | Warfarin | Cefoperazone | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against <i>Pseudomonas</i> infections. It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, per... | Moderate | 1 | [
[
[
126,
24,
1458
]
],
[
[
126,
63,
277
],
[
277,
1,
1458
]
],
[
[
126,
24,
1402
],
[
1402,
40,
1458
]
],
[
[
126,
24,
1227
],
[
1227,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefoperazone"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefmetazole"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefmetazole and Cefmetazole (Compound) resembles Cefoperazone (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefotetan and Cefotetan (Compound) resembles Cefoperazone (Compound)
... |
DB00196 | DB12825 | 600 | 1,375 | [
"DDInter743",
"DDInter1032"
] | Fluconazole | Lefamulin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
600,
25,
1375
]
],
[
[
600,
23,
112
],
[
112,
23,
1375
]
],
[
[
600,
24,
159
],
[
159,
63,
1375
]
],
[
[
600,
24,
1532
],
[
1532,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and ... |
DB08895 | DB10276 | 976 | 1,624 | [
"DDInter1825",
"DDInter1623"
] | Tofacitinib | Rotavirus vaccine | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
976,
25,
1624
]
],
[
[
976,
64,
617
],
[
617,
24,
1624
]
],
[
[
976,
64,
552
],
[
552,
25,
1624
]
],
[
[
976,
25,
1583
],
[
1583,
... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
],
[
"Budesonide",
... | Tofacitinib may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Tofacitinib may lead to a major life threatening interaction when taken with Carmustine and Carmustine may lead to a ma... |
DB06589 | DB14443 | 1,250 | 987 | [
"DDInter1400",
"DDInter1931"
] | Pazopanib | Vibrio cholerae CVD 103-HgR strain live antigen | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1250,
24,
987
]
],
[
[
1250,
63,
1220
],
[
1220,
24,
987
]
],
[
[
1250,
25,
351
],
[
351,
24,
987
]
],
[
[
1250,
24,
1362
],
[
1362,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Pazopanib may lead to a major life threatening interaction when taken ... |
DB00361 | DB12267 | 134 | 1,476 | [
"DDInter1939",
"DDInter233"
] | Vinorelbine | Brigatinib | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
134,
24,
1476
]
],
[
[
134,
63,
168
],
[
168,
23,
1476
]
],
[
[
134,
24,
629
],
[
629,
24,
1476
]
],
[
[
134,
63,
1184
],
[
1184,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolim... |
DB00035 | DB00333 | 1,314 | 576 | [
"DDInter507",
"DDInter1166"
] | Desmopressin | Methadone | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Moderate | 1 | [
[
[
1314,
24,
576
]
],
[
[
1314,
24,
998
],
[
998,
40,
576
]
],
[
[
1314,
24,
1164
],
[
1164,
1,
576
]
],
[
[
1314,
21,
28691
],
[
28691,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methadone"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Methadone (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Methado... |
DB00445 | DB11793 | 322 | 738 | [
"DDInter655",
"DDInter1297"
] | Epirubicin | Niraparib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
322,
24,
738
]
],
[
[
322,
24,
1213
],
[
1213,
24,
738
]
],
[
[
322,
24,
1033
],
[
1033,
63,
738
]
],
[
[
322,
63,
1253
],
[
1253,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib ... |
DB01229 | DB08904 | 973 | 375 | [
"DDInter1377",
"DDInter342"
] | Paclitaxel | Certolizumab pegol | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
973,
25,
375
]
],
[
[
973,
63,
1461
],
[
1461,
23,
375
]
],
[
[
973,
63,
231
],
[
231,
24,
375
]
],
[
[
973,
24,
1047
],
[
1047,
... | [
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vit... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Sta... |
DB00254 | DB01174 | 964 | 697 | [
"DDInter598",
"DDInter1442"
] | Doxycycline | Phenobarbital | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
964,
24,
697
]
],
[
[
964,
24,
759
],
[
759,
1,
697
]
],
[
[
964,
63,
362
],
[
362,
1,
697
]
],
[
[
964,
24,
536
],
[
536,
40,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compou... |
DB00026 | DB00641 | 1,184 | 467 | [
"DDInter94",
"DDInter1675"
] | Anakinra | Simvastatin | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
1184,
24,
467
]
],
[
[
1184,
24,
1428
],
[
1428,
23,
467
]
],
[
[
1184,
24,
126
],
[
126,
62,
467
]
],
[
[
1184,
24,
800
],
[
800,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may cause a minor interaction that can limit clinical effects when taken with Simvastatin
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may ... |
DB00420 | DB09104 | 508 | 286 | [
"DDInter1532",
"DDInter1118"
] | Promazine | Magnesium hydroxide | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
508,
24,
286
]
],
[
[
508,
1,
820
],
[
820,
23,
286
]
],
[
[
508,
35,
401
],
[
401,
23,
286
]
],
[
[
508,
24,
1559
],
[
1559,
23... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may cause ... | Promazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Promazine (Compound) resembles Promethazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pro... |
DB00738 | DB01244 | 485 | 762 | [
"DDInter1420",
"DDInter192"
] | Pentamidine | Bepridil | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
485,
25,
762
]
],
[
[
485,
63,
675
],
[
675,
40,
762
]
],
[
[
485,
6,
12523
],
[
12523,
45,
762
]
],
[
[
485,
21,
28698
],
[
28698,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],
[
"De... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Bepridil (Compound)
Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound)
Pentamidine (Compound) causes Insomnia (Side Effect)... |
DB00727 | DB06691 | 685 | 849 | [
"DDInter1304",
"DDInter1155"
] | Nitroglycerin | Mepyramine | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
685,
24,
849
]
],
[
[
685,
63,
1648
],
[
1648,
24,
849
]
],
[
[
685,
24,
407
],
[
407,
63,
849
]
],
[
[
685,
23,
262
],
[
262,
2... | [
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opi... |
DB00549 | DB09054 | 522 | 384 | [
"DDInter1955",
"DDInter905"
] | Zafirlukast | Idelalisib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
522,
24,
384
]
],
[
[
522,
23,
222
],
[
222,
23,
384
]
],
[
[
522,
62,
1230
],
[
1230,
23,
384
]
],
[
[
522,
24,
1627
],
[
1627,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Zafirlukast",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Citalopram and Citalopr... |
DB00352 | DB08901 | 482 | 1,468 | [
"DDInter1814",
"DDInter1492"
] | Tioguanine | Ponatinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
482,
24,
1468
]
],
[
[
482,
24,
478
],
[
478,
24,
1468
]
],
[
[
482,
6,
7129
],
[
7129,
57,
1468
]
],
[
[
482,
21,
28722
],
[
28722,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Tioguanine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Ponatinib (Compound)
Tioguanine (Comp... |
DB00218 | DB11978 | 1,176 | 124 | [
"DDInter1247",
"DDInter822"
] | Moxifloxacin | Glasdegib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1176,
25,
124
]
],
[
[
1176,
23,
112
],
[
112,
23,
124
]
],
[
[
1176,
25,
79
],
[
79,
24,
124
]
],
[
[
1176,
1,
739
],
[
739,
24... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Moxifloxacin may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cau... |
DB00060 | DB00900 | 912 | 45 | [
"DDInter947",
"DDInter544"
] | Interferon beta-1a | Didanosine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Moderate | 1 | [
[
[
912,
24,
45
]
],
[
[
912,
24,
1669
],
[
1669,
62,
45
]
],
[
[
912,
24,
1142
],
[
1142,
63,
45
]
],
[
[
912,
63,
491
],
[
491,
24... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minocycline... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and Minocycline may cause a minor interaction that can limit clinical effects when taken with Didanosine
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Orlis... |
DB01583 | DB06718 | 624 | 1,687 | [
"DDInter1075",
"DDInter1709"
] | Liotrix | Stanozolol | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
624,
24,
1687
]
],
[
[
624,
63,
1026
],
[
1026,
40,
1687
]
],
[
[
624,
40,
1152
],
[
1152,
24,
1687
]
],
[
[
624,
63,
1144
],
[
1144,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
],
[
"... | Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone (Compound) resembles Stanozolol (Compound)
Liotrix (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Stanozolol
... |
DB00624 | DB08880 | 1,561 | 1,510 | [
"DDInter1775",
"DDInter1771"
] | Testosterone | Teriflunomide | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1561,
25,
1510
]
],
[
[
1561,
24,
129
],
[
129,
63,
1510
]
],
[
[
1561,
24,
1144
],
[
1144,
24,
1510
]
],
[
[
1561,
40,
303
],
[
303,
... | [
[
[
"Testosterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
"E... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinid... |
DB00880 | DB01168 | 359 | 1,053 | [
"DDInter360",
"DDInter1526"
] | Chlorothiazide | Procarbazine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
359,
24,
1053
]
],
[
[
359,
24,
848
],
[
848,
40,
1053
]
],
[
[
359,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
359,
62,
126
],
[
126,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Chlorothiazide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Chlorothiazide may cause a minor int... |
DB00758 | DB01050 | 1,347 | 848 | [
"DDInter413",
"DDInter900"
] | Clopidogrel | Ibuprofen | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1347,
24,
848
]
],
[
[
1347,
6,
3486
],
[
3486,
45,
848
]
],
[
[
1347,
21,
28773
],
[
28773,
60,
848
]
],
[
[
1347,
23,
297
],
[
297,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Clopidogrel (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ibuprofen (Compound)
Clopidogrel (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Clov... |
DB00635 | DB14409 | 1,573 | 1,129 | [
"DDInter1515",
"DDInter867"
] | Prednisone | Human adenovirus e serotype 4 strain cl-68578 antigen | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1573,
24,
1129
]
],
[
[
1573,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1573,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
1573,
40,
251
],
[
251... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Prednisone may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Prednisone may cause a moderate interaction that could exacerbate diseases when take... |
DB04911 | DB13074 | 968 | 877 | [
"DDInter1347",
"DDInter1110"
] | Oritavancin | Macimorelin | Oritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). Oritavancin was initially approved by the FDA in 2014 and formulated to combat susceptible gram-positive bacteria that cause skin and skin structure infections. It boasts... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
968,
24,
877
]
],
[
[
968,
24,
1320
],
[
1320,
24,
877
]
],
[
[
968,
63,
79
],
[
79,
25,
877
]
],
[
[
968,
24,
1491
],
[
1491,
2... | [
[
[
"Oritavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Oritavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Oritavancin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Oritavancin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafeni... |
DB00685 | DB01278 | 1,299 | 1,021 | [
"DDInter1887",
"DDInter1506"
] | Trovafloxacin | Pramlintide | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1299,
24,
1021
]
],
[
[
1299,
63,
1560
],
[
1560,
24,
1021
]
],
[
[
1299,
25,
891
],
[
891,
24,
1021
]
],
[
[
1299,
64,
1573
],
[
1573... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegaspargase"
],... | Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Trovafloxacin may lead to a major life threatening interaction when taken with Prednisolone and Predniso... |
DB06077 | DB06655 | 879 | 5 | [
"DDInter1102",
"DDInter1077"
] | Lumateperone | Liraglutide | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
879,
24,
5
]
],
[
[
879,
64,
353
],
[
353,
23,
5
]
],
[
[
879,
63,
245
],
[
245,
24,
5
]
],
[
[
879,
64,
1220
],
[
1220,
24,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Griseofulvin"
],
[
"Gri... | Lumateperone may lead to a major life threatening interaction when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride m... |
DB00024 | DB01278 | 818 | 1,021 | [
"DDInter1800",
"DDInter1506"
] | Thyrotropin alfa | Pramlintide | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
818,
24,
1021
]
],
[
[
818,
24,
1144
],
[
1144,
24,
1021
]
],
[
[
818,
24,
1296
],
[
1296,
63,
1021
]
],
[
[
818,
24,
1144
],
[
1144,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Insuli... |
DB00467 | DB00544 | 1,467 | 970 | [
"DDInter644",
"DDInter757"
] | Enoxacin | Fluorouracil | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Minor | 0 | [
[
[
1467,
23,
970
]
],
[
[
1467,
6,
7950
],
[
7950,
45,
970
]
],
[
[
1467,
23,
147
],
[
147,
62,
970
]
],
[
[
1467,
1,
956
],
[
956,
... | [
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fluorouracil"
]
],
[
[
"Enoxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Enoxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Fluorouracil (Compound)
Enoxacin may cause a minor interaction that can limit clinical effects when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Fluorouracil
Enoxacin (Compound) ... |
DB00023 | DB01278 | 305 | 1,021 | [
"DDInter127",
"DDInter1506"
] | Asparaginase Escherichia coli | Pramlintide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
305,
24,
1021
]
],
[
[
305,
24,
1142
],
[
1142,
24,
1021
]
],
[
[
305,
24,
1019
],
[
1019,
63,
1021
]
],
[
[
305,
25,
695
],
[
695,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases wh... |
DB00951 | DB11978 | 1,072 | 124 | [
"DDInter986",
"DDInter822"
] | Isoniazid | Glasdegib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1072,
24,
124
]
],
[
[
1072,
23,
1135
],
[
1135,
23,
124
]
],
[
[
1072,
63,
112
],
[
112,
23,
124
]
],
[
[
1072,
24,
159
],
[
159,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Isoniazid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"N... | Isoniazid may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazol... |
DB01136 | DB11837 | 772 | 1,297 | [
"DDInter305",
"DDInter1351"
] | Carvedilol | Osilodrostat | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
772,
24,
1297
]
],
[
[
772,
23,
578
],
[
578,
24,
1297
]
],
[
[
772,
63,
401
],
[
401,
24,
1297
]
],
[
[
772,
64,
688
],
[
688,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Carvedilol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
],
[
... | Carvedilol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prom... |
DB00241 | DB00687 | 288 | 870 | [
"DDInter257",
"DDInter747"
] | Butalbital | Fludrocortisone | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
288,
24,
870
]
],
[
[
288,
24,
1220
],
[
1220,
40,
870
]
],
[
[
288,
24,
392
],
[
392,
63,
870
]
],
[
[
288,
1,
536
],
[
536,
24... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction t... |
DB00556 | DB09472 | 1,262 | 1,383 | [
"DDInter1429",
"DDInter1693"
] | Perflutren | Sodium sulfate | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1262,
24,
1383
]
],
[
[
1262,
24,
609
],
[
609,
24,
1383
]
],
[
[
1262,
63,
521
],
[
521,
24,
1383
]
],
[
[
1262,
25,
1618
],
[
1618,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Goserelin... |
DB00048 | DB09075 | 1,595 | 498 | [
"DDInter435",
"DDInter621"
] | Collagenase clostridium histolyticum | Edoxaban | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
1595,
24,
498
]
],
[
[
1595,
63,
582
],
[
582,
25,
498
]
],
[
[
1595,
24,
714
],
[
714,
25,
498
]
],
[
[
1595,
24,
1421
],
[
1421,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when t... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Reteplase and Reteplase may lead to a major life threatening interaction when taken with Edoxaban
Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when... |
DB00889 | DB09241 | 1,133 | 1,629 | [
"DDInter840",
"DDInter1186"
] | Granisetron | Methylene blue | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1133,
25,
1629
]
],
[
[
1133,
63,
1052
],
[
1052,
24,
1629
]
],
[
[
1133,
24,
1148
],
[
1148,
24,
1629
]
],
[
[
1133,
23,
697
],
[
697... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
],
[
"Ritod... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB05015 | DB08904 | 1,077 | 375 | [
"DDInter174",
"DDInter342"
] | Belinostat | Certolizumab pegol | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
1077,
25,
375
]
],
[
[
1077,
24,
200
],
[
200,
63,
375
]
],
[
[
1077,
63,
66
],
[
66,
24,
375
]
],
[
[
1077,
24,
1430
],
[
1430,
... | [
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Belinostat may cause a moderate interaction that could exacerbate diseases when taken with E... |
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