drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB05294 | DB12130 | 1,069 | 1,017 | [
"DDInter1917",
"DDInter1094"
] | Vandetanib | Lorlatinib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1069,
24,
1017
]
],
[
[
1069,
25,
1612
],
[
1612,
23,
1017
]
],
[
[
1069,
25,
786
],
[
786,
24,
1017
]
],
[
[
1069,
63,
126
],
[
126,
... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostemsav... | Vandetanib may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Vandetanib may lead to a major life threatening interaction when taken with Rilpivirine and Rilpivirine may cause a moderate in... |
DB00076 | DB00831 | 1,352 | 1,178 | [
"DDInter555",
"DDInter1866"
] | Digoxin Immune Fab (Ovine) | Trifluoperazine | Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin. | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1352,
24,
1178
]
],
[
[
1352,
24,
216
],
[
216,
40,
1178
]
],
[
[
1352,
25,
57
],
[
57,
64,
1178
]
],
[
[
1352,
24,
216
],
[
216,
... | [
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Digoxin Immune Fab (Ovine) may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Trifluoperazine (Compound)
Digoxin Immune Fab (Ovine) may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide m... |
DB00363 | DB11703 | 695 | 405 | [
"DDInter419",
"DDInter9"
] | Clozapine | Acalabrutinib | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
695,
25,
405
]
],
[
[
695,
63,
1324
],
[
1324,
24,
405
]
],
[
[
695,
64,
1101
],
[
1101,
24,
405
]
],
[
[
695,
25,
951
],
[
951,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"Troglit... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Clozapine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may c... |
DB00601 | DB06273 | 453 | 980 | [
"DDInter1073",
"DDInter1824"
] | Linezolid | Tocilizumab | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
453,
24,
980
]
],
[
[
453,
24,
309
],
[
309,
24,
980
]
],
[
[
453,
24,
850
],
[
850,
63,
980
]
],
[
[
453,
63,
597
],
[
597,
24,... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin ... |
DB01234 | DB01259 | 1,220 | 392 | [
"DDInter513",
"DDInter1024"
] | Dexamethasone | Lapatinib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1220,
24,
392
]
],
[
[
1220,
10,
11579
],
[
11579,
44,
392
]
],
[
[
1220,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1220,
7,
3727
],
[
3727,... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Dexamethasone",
"{u} (Compound) palliates {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease)... | Dexamethasone (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Dexamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Dexamethasone (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
De... |
DB00322 | DB00446 | 141 | 597 | [
"DDInter742",
"DDInter351"
] | Floxuridine | Chloramphenicol | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
141,
24,
597
]
],
[
[
141,
18,
9205
],
[
9205,
57,
597
]
],
[
[
141,
21,
29373
],
[
29373,
60,
597
]
],
[
[
141,
24,
450
],
[
450,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Floxuridine",
"{u} (Compound) downregulates {v} (Gene)",
"IFRD2"
],
[
"IFRD2",
"{u} (Gene) is downregulate... | Floxuridine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Chloramphenicol (Compound)
Floxuridine (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Chloramphenicol (Compound)
Floxuridine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00420 | DB00434 | 508 | 13 | [
"DDInter1532",
"DDInter459"
] | Promazine | Cyproheptadine | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
508,
24,
13
]
],
[
[
508,
1,
11321
],
[
11321,
40,
13
]
],
[
[
508,
1,
104
],
[
104,
63,
13
]
],
[
[
508,
6,
10104
],
[
10104,
4... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound)",
"Metixene"
],
[
"Metixene",
"{u} (Compound) resembles ... | Promazine (Compound) resembles Metixene (Compound) and Metixene (Compound) resembles Cyproheptadine (Compound)
Promazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Promazine (Compound) binds HRH1 (Gene) and... |
DB00572 | DB00734 | 85 | 1,664 | [
"DDInter136",
"DDInter1605"
] | Atropine | Risperidone | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
85,
24,
1664
]
],
[
[
85,
24,
924
],
[
924,
40,
1664
]
],
[
[
85,
21,
28787
],
[
28787,
60,
1664
]
],
[
[
85,
63,
1089
],
[
1089,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Atropine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Risperidone (Compound)
Atropine may cause a moderate interaction ... |
DB00445 | DB06403 | 322 | 1,204 | [
"DDInter655",
"DDInter62"
] | Epirubicin | Ambrisentan | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Moderate | 1 | [
[
[
322,
24,
1204
]
],
[
[
322,
63,
600
],
[
600,
23,
1204
]
],
[
[
322,
24,
609
],
[
609,
23,
1204
]
],
[
[
322,
25,
868
],
[
868,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambrisentan"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ambrisentan
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and C... |
DB00970 | DB11627 | 0 | 1,367 | [
"DDInter466",
"DDInter860"
] | Dactinomycin | Hepatitis B Vaccine (Recombinant) | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
0,
24,
1367
]
],
[
[
0,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
0,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
0,
24,
259
],
[
259,
24,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Dactinomycin may lead to a major life threatening interaction when taken with Cladrib... |
DB00530 | DB08867 | 1,195 | 807 | [
"DDInter667",
"DDInter1897"
] | Erlotinib | Ulipristal | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Moderate | 1 | [
[
[
1195,
24,
807
]
],
[
[
1195,
24,
609
],
[
609,
23,
807
]
],
[
[
1195,
24,
1017
],
[
1017,
63,
807
]
],
[
[
1195,
24,
478
],
[
478,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lo... |
DB00762 | DB06688 | 613 | 1,430 | [
"DDInter973",
"DDInter1677"
] | Irinotecan | Sipuleucel-T | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
613,
24,
1430
]
],
[
[
613,
24,
869
],
[
869,
24,
1430
]
],
[
[
613,
25,
676
],
[
676,
63,
1430
]
],
[
[
613,
24,
713
],
[
713,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Irinotecan may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may ca... |
DB06209 | DB14730 | 256 | 1,412 | [
"DDInter1508",
"DDInter264"
] | Prasugrel | Calaspargase pegol | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
256,
24,
1412
]
],
[
[
256,
25,
792
],
[
792,
24,
1412
]
],
[
[
256,
75,
1347
],
[
1347,
24,
1412
]
],
[
[
256,
64,
553
],
[
553,
... | [
[
[
"Prasugrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
"Riv... | Prasugrel may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Prasugrel (Compound) resembles Clopidogrel (Compound) and Prasugrel may lead to a major life threatening interaction w... |
DB00323 | DB09122 | 1,062 | 1,613 | [
"DDInter1829",
"DDInter1409"
] | Tolcapone | Peginterferon beta-1a | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1062,
24,
1613
]
],
[
[
1062,
24,
267
],
[
267,
24,
1613
]
],
[
[
1062,
63,
1560
],
[
1560,
24,
1613
]
],
[
[
1062,
40,
24
],
[
24,
... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase... |
DB01155 | DB11978 | 872 | 124 | [
"DDInter813",
"DDInter822"
] | Gemifloxacin | Glasdegib | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
872,
24,
124
]
],
[
[
872,
62,
112
],
[
112,
23,
124
]
],
[
[
872,
63,
79
],
[
79,
24,
124
]
],
[
[
872,
40,
739
],
[
739,
24,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Gemifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and So... |
DB00647 | DB00748 | 675 | 662 | [
"DDInter528",
"DDInter297"
] | Dextropropoxyphene | Carbinoxamine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Major | 2 | [
[
[
675,
25,
662
]
],
[
[
675,
24,
28
],
[
28,
40,
662
]
],
[
[
675,
75,
1594
],
[
1594,
24,
662
]
],
[
[
675,
64,
128
],
[
128,
24,... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
],
[... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Dextropropoxyphene (Compound) resembles Doxylamine (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with D... |
DB00281 | DB01259 | 608 | 392 | [
"DDInter1066",
"DDInter1024"
] | Lidocaine | Lapatinib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
608,
24,
392
]
],
[
[
608,
6,
2192
],
[
2192,
45,
392
]
],
[
[
608,
18,
15501
],
[
15501,
57,
392
]
],
[
[
608,
21,
28695
],
[
28695,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"EGFR"
],
[
"EGFR",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds EGFR (Gene) and EGFR (Gene) is bound by Lapatinib (Compound)
Lidocaine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Lapatinib (Compound)
Lidocaine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Lapatinib (Compound)
Lidocaine ma... |
DB01097 | DB08879 | 1,377 | 632 | [
"DDInter1033",
"DDInter173"
] | Leflunomide | Belimumab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Major | 2 | [
[
[
1377,
25,
632
]
],
[
[
1377,
62,
1461
],
[
1461,
23,
632
]
],
[
[
1377,
23,
1114
],
[
1114,
62,
632
]
],
[
[
1377,
25,
713
],
[
713,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belimumab"
]
],
[
[
"Leflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Leflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Belimumab
Leflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfat... |
DB01177 | DB06372 | 77 | 259 | [
"DDInter904",
"DDInter1594"
] | Idarubicin | Rilonacept | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
77,
24,
259
]
],
[
[
77,
63,
1461
],
[
1461,
23,
259
]
],
[
[
77,
63,
0
],
[
0,
24,
259
]
],
[
[
77,
24,
1619
],
[
1619,
63,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin and Dactinom... |
DB00586 | DB06715 | 1,512 | 239 | [
"DDInter537",
"DDInter1500"
] | Diclofenac | Potassium Iodide | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyr... | Moderate | 1 | [
[
[
1512,
24,
239
]
],
[
[
1512,
21,
29195
],
[
29195,
60,
239
]
],
[
[
1512,
24,
1263
],
[
1263,
24,
239
]
],
[
[
1512,
24,
877
],
[
877,... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium Iodide"
]
],
[
[
"Diclofenac",
"{u} (Compound) causes {v} (Side Effect)",
"Tingling sensation"
],
[
"Tingling sensation",
"{... | Diclofenac (Compound) causes Tingling sensation (Side Effect) and Tingling sensation (Side Effect) is caused by Potassium Iodide (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac may cause a moderate interaction that could exacerbate diseases w... |
DB00581 | DB01259 | 355 | 392 | [
"DDInter1018",
"DDInter1024"
] | Lactulose | Lapatinib | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
355,
24,
392
]
],
[
[
355,
21,
28736
],
[
28736,
60,
392
]
],
[
[
355,
24,
898
],
[
898,
24,
392
]
],
[
[
355,
63,
1251
],
[
1251,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Lactulose",
"{u} (Compound) causes {v} (Side Effect)",
"Dehydration"
],
[
"Dehydration",
"{u} (Side Effect) is cau... | Lactulose (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Lapatinib (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Propofol and Propofol may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib
... |
DB00081 | DB11718 | 273 | 927 | [
"DDInter1838",
"DDInter640"
] | Tositumomab | Encorafenib | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
273,
25,
927
]
],
[
[
273,
24,
1100
],
[
1100,
24,
927
]
],
[
[
273,
25,
1259
],
[
1259,
63,
927
]
],
[
[
273,
25,
1510
],
[
1510,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
"Venlaf... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Tositumomab may lead to a major life threatening interaction when taken with Baricitinib and Baricitinib may... |
DB00262 | DB01005 | 552 | 995 | [
"DDInter302",
"DDInter894"
] | Carmustine | Hydroxyurea | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
552,
24,
995
]
],
[
[
552,
5,
11555
],
[
11555,
44,
995
]
],
[
[
552,
21,
29276
],
[
29276,
60,
995
]
],
[
[
552,
23,
1299
],
[
1299,
... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Carmustine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disea... | Carmustine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Hydroxyurea (Compound)
Carmustine (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Hydroxyurea (Compound)
Carmustine may cause a minor interaction that can limit clinical effect... |
DB00773 | DB00911 | 896 | 458 | [
"DDInter702",
"DDInter1811"
] | Etoposide | Tinidazole | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
896,
24,
458
]
],
[
[
896,
24,
112
],
[
112,
1,
458
]
],
[
[
896,
6,
8374
],
[
8374,
45,
458
]
],
[
[
896,
21,
29340
],
[
29340,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tinidazole (Compound)
Etoposide (Compound) causes Stevens-Johnson syndrome (Side Eff... |
DB08864 | DB12332 | 786 | 1,619 | [
"DDInter1595",
"DDInter1626"
] | Rilpivirine | Rucaparib | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
786,
24,
1619
]
],
[
[
786,
62,
112
],
[
112,
23,
1619
]
],
[
[
786,
63,
1419
],
[
1419,
24,
1619
]
],
[
[
786,
24,
159
],
[
159,
... | [
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Rilpivirine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Rilpivirine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imati... |
DB00861 | DB00959 | 914 | 1,486 | [
"DDInter551",
"DDInter1191"
] | Diflunisal | Methylprednisolone | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
914,
24,
1486
]
],
[
[
914,
63,
175
],
[
175,
40,
1486
]
],
[
[
914,
63,
167
],
[
167,
1,
1486
]
],
[
[
914,
24,
1220
],
[
1220,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB00472 | DB09472 | 758 | 1,383 | [
"DDInter758",
"DDInter1693"
] | Fluoxetine | Sodium sulfate | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
758,
24,
1383
]
],
[
[
758,
24,
609
],
[
609,
24,
1383
]
],
[
[
758,
63,
521
],
[
521,
24,
1383
]
],
[
[
758,
64,
1466
],
[
1466,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin... |
DB00491 | DB01105 | 127 | 222 | [
"DDInter1217",
"DDInter1665"
] | Miglitol | Sibutramine | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
127,
24,
222
]
],
[
[
127,
21,
29665
],
[
29665,
60,
222
]
],
[
[
127,
63,
839
],
[
839,
23,
222
]
],
[
[
127,
24,
984
],
[
984,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Miglitol",
"{u} (Compound) causes {v} (Side Effect)",
"Intestinal obstruction"
],
[
"Intestinal obstruction",
"{u... | Miglitol (Compound) causes Intestinal obstruction (Side Effect) and Intestinal obstruction (Side Effect) is caused by Sibutramine (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepafloxacin may cause a minor interaction that can limit clinical effe... |
DB01320 | DB12141 | 651 | 971 | [
"DDInter783",
"DDInter817"
] | Fosphenytoin | Gilteritinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
651,
25,
971
]
],
[
[
651,
25,
1135
],
[
1135,
23,
971
]
],
[
[
651,
25,
466
],
[
466,
62,
971
]
],
[
[
651,
63,
112
],
[
112,
2... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{... | Fosphenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Fosphenytoin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor i... |
DB00092 | DB00708 | 58 | 1,454 | [
"DDInter40",
"DDInter1718"
] | Alefacept | Sufentanil | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
58,
24,
1454
]
],
[
[
58,
24,
704
],
[
704,
40,
1454
]
],
[
[
58,
24,
1093
],
[
1093,
63,
1454
]
],
[
[
58,
24,
1101
],
[
1101,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exace... |
DB00333 | DB01211 | 576 | 609 | [
"DDInter1166",
"DDInter393"
] | Methadone | Clarithromycin | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
576,
25,
609
]
],
[
[
576,
6,
4973
],
[
4973,
45,
609
]
],
[
[
576,
21,
28662
],
[
28662,
60,
609
]
],
[
[
576,
64,
600
],
[
600,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Clarith... | Methadone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Methadone (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Methadone may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause... |
DB00983 | DB11915 | 480 | 1,293 | [
"DDInter776",
"DDInter1909"
] | Formoterol | Valbenazine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
480,
24,
1293
]
],
[
[
480,
63,
521
],
[
521,
24,
1293
]
],
[
[
480,
24,
401
],
[
401,
24,
1293
]
],
[
[
480,
24,
1619
],
[
1619,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prome... |
DB06081 | DB06228 | 1,046 | 792 | [
"DDInter286",
"DDInter1609"
] | Caplacizumab | Rivaroxaban | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1046,
25,
792
]
],
[
[
1046,
23,
944
],
[
944,
62,
792
]
],
[
[
1046,
24,
1412
],
[
1412,
63,
792
]
],
[
[
1046,
63,
901
],
[
901,
... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Caplacizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomil... | Caplacizumab may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and... |
DB00059 | DB00766 | 1,560 | 1,675 | [
"DDInter1404",
"DDInter394"
] | Pegaspargase | Clavulanic acid | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with [Amoxicillin] or [Ticarcillin] to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections. Clavulanic acid is derived from the organism Streptomyces... | Moderate | 1 | [
[
[
1560,
24,
1675
]
],
[
[
1560,
24,
850
],
[
850,
63,
1675
]
],
[
[
1560,
24,
482
],
[
482,
24,
1675
]
],
[
[
1560,
25,
1377
],
[
1377,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clavulanic acid"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedoti... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Clavulanic acid
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken... |
DB00014 | DB01165 | 521 | 1,539 | [
"DDInter839",
"DDInter1325"
] | Goserelin | Ofloxacin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
521,
24,
1539
]
],
[
[
521,
25,
1176
],
[
1176,
1,
1539
]
],
[
[
521,
25,
945
],
[
945,
40,
1539
]
],
[
[
521,
24,
956
],
[
956,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxaci... | Goserelin may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Goserelin may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Goserelin may cause a mode... |
DB08826 | DB09322 | 1,292 | 1,114 | [
"DDInter489",
"DDInter1966"
] | Deferiprone | Zinc sulfate | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
1292,
24,
1114
]
],
[
[
1292,
64,
66
],
[
66,
23,
1114
]
],
[
[
1292,
24,
260
],
[
260,
62,
1114
]
],
[
[
1292,
25,
1583
],
[
1583,
... | [
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Efalizumab"
],
[
"Efaliz... | Deferiprone may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Ferrous sulfate anhydrous and Ferr... |
DB00353 | DB01128 | 588 | 918 | [
"DDInter1187",
"DDInter204"
] | Methylergometrine | Bicalutamide | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
588,
24,
918
]
],
[
[
588,
24,
129
],
[
129,
40,
918
]
],
[
[
588,
6,
8374
],
[
8374,
45,
918
]
],
[
[
588,
21,
28936
],
[
28936,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamid... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Methylergometrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Methylergometrine (Compound) causes Hyperhid... |
DB00701 | DB06772 | 1,091 | 310 | [
"DDInter90",
"DDInter259"
] | Amprenavir | Cabazitaxel | Amprenavir is a protease inhibitor used to treat HIV infection. | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
1091,
24,
310
]
],
[
[
1091,
25,
973
],
[
973,
24,
310
]
],
[
[
1091,
6,
7524
],
[
7524,
45,
310
]
],
[
[
1091,
21,
28692
],
[
28692,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
],
[
"Paclitaxe... | Amprenavir may lead to a major life threatening interaction when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Amprenavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cabazitaxel (Compound)
Amprenavir (Compound) causes Me... |
DB00562 | DB09082 | 1,014 | 659 | [
"DDInter188",
"DDInter1934"
] | Benzthiazide | Vilanterol | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1014,
24,
659
]
],
[
[
1014,
24,
1220
],
[
1220,
23,
659
]
],
[
[
1014,
63,
251
],
[
251,
23,
659
]
],
[
[
1014,
24,
1296
],
[
1296,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone... |
DB00078 | DB09074 | 1,172 | 1,362 | [
"DDInter898",
"DDInter1327"
] | Ibritumomab tiuxetan | Olaparib | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1172,
24,
1362
]
],
[
[
1172,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
1172,
25,
702
],
[
702,
24,
1362
]
],
[
[
1172,
25,
710
],
[
710,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinum... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Anagrelide and A... |
DB00657 | DB00852 | 1,360 | 1,445 | [
"DDInter1130",
"DDInter1545"
] | Mecamylamine | Pseudoephedrine | A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1360,
24,
1445
]
],
[
[
1360,
24,
22
],
[
22,
40,
1445
]
],
[
[
1360,
21,
28714
],
[
28714,
60,
1445
]
],
[
[
1360,
24,
1344
],
[
1344... | [
[
[
"Mecamylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Mecamylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
],
... | Mecamylamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine (Compound) resembles Pseudoephedrine (Compound)
Mecamylamine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Pseudoephedrine (Compound)
Mecamylamine may cause a moderate ... |
DB00350 | DB01168 | 1,214 | 1,053 | [
"DDInter1226",
"DDInter1526"
] | Minoxidil | Procarbazine | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1214,
24,
1053
]
],
[
[
1214,
64,
1000
],
[
1000,
24,
1053
]
],
[
[
1214,
24,
9
],
[
9,
63,
1053
]
],
[
[
1214,
24,
104
],
[
104,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Minoxidil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Guanadrel"
],
[
"Guanadrel",... | Minoxidil may lead to a major life threatening interaction when taken with Guanadrel and Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazin... |
DB00205 | DB00495 | 929 | 139 | [
"DDInter1550",
"DDInter1961"
] | Pyrimethamine | Zidovudine | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Moderate | 1 | [
[
[
929,
24,
139
]
],
[
[
929,
6,
6017
],
[
6017,
45,
139
]
],
[
[
929,
21,
29209
],
[
29209,
60,
139
]
],
[
[
929,
24,
304
],
[
304,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
]
],
[
[
"Pyrimethamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compo... | Pyrimethamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Zidovudine (Compound)
Pyrimethamine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Zidovudine (Compound)
Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate... |
DB00163 | DB00208 | 1,461 | 1,018 | [
"DDInter1943",
"DDInter1804"
] | Vitamin E | Ticlopidine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Moderate | 1 | [
[
[
1461,
24,
1018
]
],
[
[
1461,
24,
1347
],
[
1347,
64,
1018
]
],
[
[
1461,
23,
1486
],
[
1486,
62,
1018
]
],
[
[
1461,
24,
885
],
[
885... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone and Methylpredniso... |
DB09322 | DB11817 | 1,114 | 1,259 | [
"DDInter1966",
"DDInter165"
] | Zinc sulfate | Baricitinib | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Minor | 0 | [
[
[
1114,
23,
1259
]
],
[
[
1114,
62,
1220
],
[
1220,
25,
1259
]
],
[
[
1114,
23,
1316
],
[
1316,
25,
1259
]
],
[
[
1114,
23,
1303
],
[
13... | [
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Baricitinib"
]
],
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
... | Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may lead to a major life threatening interaction when taken with Baricitinib
Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Durvalumab and Durvalumab may... |
DB01232 | DB11691 | 1,327 | 1,499 | [
"DDInter1640",
"DDInter1258"
] | Saquinavir | Naldemedine | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
1327,
24,
1499
]
],
[
[
1327,
63,
723
],
[
723,
24,
1499
]
],
[
[
1327,
1,
798
],
[
798,
24,
1499
]
],
[
[
1327,
25,
1670
],
[
1670,
... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Saquinavir (Compound) resembles Nelfinavir (Compound) and Nelfinavir may cause a moderate interaction that coul... |
DB08901 | DB09481 | 1,468 | 460 | [
"DDInter1492",
"DDInter1113"
] | Ponatinib | Magnesium carbonate | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1468,
23,
460
]
],
[
[
1468,
63,
1252
],
[
1252,
23,
460
]
],
[
[
1468,
64,
831
],
[
831,
23,
460
]
],
[
[
1468,
62,
752
],
[
752,
... | [
[
[
"Ponatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Ponatinib may lead to a major life threatening interaction when taken with Indomethacin and Indomethacin may cau... |
DB00705 | DB11995 | 441 | 1,634 | [
"DDInter496",
"DDInter143"
] | Delavirdine | Avatrombopag | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
441,
24,
1634
]
],
[
[
441,
24,
760
],
[
760,
24,
1634
]
],
[
[
441,
25,
913
],
[
913,
24,
1634
]
],
[
[
441,
63,
254
],
[
254,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Delavirdine may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may ... |
DB00197 | DB00497 | 1,324 | 828 | [
"DDInter1881",
"DDInter1366"
] | Troglitazone | Oxycodone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
1324,
24,
828
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],
[
[
1324,
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[
267,
64,
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],
[
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1324,
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],
[
401,
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]
],
[
[
1324,
23,
1101
],
[
1101,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may lead to a major life threatening interaction when taken with Oxycodone
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may... |
DB00581 | DB11089 | 355 | 338 | [
"DDInter1018",
"DDInter579"
] | Lactulose | Docusate | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation. Docusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass . Docusate can be orally or rectally administered. Docusate is on the World Health Organization's... | Moderate | 1 | [
[
[
355,
24,
338
]
],
[
[
355,
23,
16
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[
16,
23,
338
]
],
[
[
355,
24,
720
],
[
720,
24,
338
]
],
[
[
355,
23,
16
],
[
16,
23,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Docusate"
]
],
[
[
"Lactulose",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
],
[
"... | Lactulose may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Docusate
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Mineral oil... |
DB06273 | DB09074 | 980 | 1,362 | [
"DDInter1824",
"DDInter1327"
] | Tocilizumab | Olaparib | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
980,
24,
1362
]
],
[
[
980,
63,
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],
[
896,
24,
1362
]
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[
[
980,
64,
1683
],
[
1683,
24,
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]
],
[
[
980,
24,
1468
],
[
1468,
... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Tocilizumab may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause ... |
DB00398 | DB00776 | 79 | 1,335 | [
"DDInter1702",
"DDInter1360"
] | Sorafenib | Oxcarbazepine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
79,
24,
1335
]
],
[
[
79,
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126
],
[
126,
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[
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79,
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1264
],
[
1264,
63,
1335
]
],
[
[
79,
63,
21
],
[
21,
1,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Oxcarbazepine (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerba... |
DB00682 | DB09061 | 126 | 1,627 | [
"DDInter1951",
"DDInter284"
] | Warfarin | Cannabidiol | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
126,
24,
1627
]
],
[
[
126,
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723
],
[
723,
23,
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]
],
[
[
126,
24,
760
],
[
760,
62,
1627
]
],
[
[
126,
24,
660
],
[
660,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat ... |
DB00526 | DB00834 | 1,555 | 932 | [
"DDInter1355",
"DDInter1215"
] | Oxaliplatin | Mifepristone | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
1555,
25,
932
]
],
[
[
1555,
24,
112
],
[
112,
62,
932
]
],
[
[
1555,
24,
480
],
[
480,
63,
932
]
],
[
[
1555,
63,
597
],
[
597,
... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Met... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Mifepristone
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol an... |
DB00615 | DB01254 | 690 | 1,213 | [
"DDInter1589",
"DDInter484"
] | Rifabutin | Dasatinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
690,
25,
1213
]
],
[
[
690,
6,
8374
],
[
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45,
1213
]
],
[
[
690,
18,
2183
],
[
2183,
57,
1213
]
],
[
[
690,
21,
28882
],
[
28882,... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"... | Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Rifabutin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dasatinib (Compound)
Rifabutin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is cause... |
DB00315 | DB00757 | 767 | 1,166 | [
"DDInter1969",
"DDInter581"
] | Zolmitriptan | Dolasetron | Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptan... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
767,
25,
1166
]
],
[
[
767,
21,
29081
],
[
29081,
60,
1166
]
],
[
[
767,
24,
752
],
[
752,
23,
1166
]
],
[
[
767,
63,
475
],
[
475,
... | [
[
[
"Zolmitriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Zolmitriptan",
"{u} (Compound) causes {v} (Side Effect)",
"Angioedema"
],
[
"Angioedema",
"{u} (Side Effect) is caused by {v}... | Zolmitriptan (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Dolasetron (Compound)
Zolmitriptan may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Dol... |
DB00529 | DB00959 | 789 | 1,486 | [
"DDInter779",
"DDInter1191"
] | Foscarnet | Methylprednisolone | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
789,
24,
1486
]
],
[
[
789,
24,
175
],
[
175,
40,
1486
]
],
[
[
789,
24,
167
],
[
167,
1,
1486
]
],
[
[
789,
63,
251
],
[
251,
1... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Me... |
DB00220 | DB00570 | 798 | 147 | [
"DDInter1276",
"DDInter1936"
] | Nelfinavir | Vinblastine | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Major | 2 | [
[
[
798,
25,
147
]
],
[
[
798,
25,
134
],
[
134,
24,
147
]
],
[
[
798,
6,
8374
],
[
8374,
45,
147
]
],
[
[
798,
7,
5360
],
[
5360,
4... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinblastine"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinorelbine"
],
[
"Vinorelbine",
"{u... | Nelfinavir may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinblastine (Compound)
Nelfinavir (Compound) upregul... |
DB00794 | DB00911 | 759 | 458 | [
"DDInter1521",
"DDInter1811"
] | Primidone | Tinidazole | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
759,
24,
458
]
],
[
[
759,
24,
112
],
[
112,
1,
458
]
],
[
[
759,
6,
8374
],
[
8374,
45,
458
]
],
[
[
759,
21,
28723
],
[
28723,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Primidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tinidazole (Compound)
Primidone (Compound) causes Malnutrition (Side Effect) and Mal... |
DB00358 | DB09276 | 1,010 | 381 | [
"DDInter1140",
"DDInter1682"
] | Mefloquine | Sodium aurothiomalate | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Major | 2 | [
[
[
1010,
25,
381
]
],
[
[
1010,
25,
1593
],
[
1593,
24,
381
]
],
[
[
1010,
23,
112
],
[
112,
24,
381
]
],
[
[
1010,
24,
770
],
[
770,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotinib",
... | Mefloquine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronida... |
DB00015 | DB11793 | 582 | 738 | [
"DDInter1585",
"DDInter1297"
] | Reteplase | Niraparib | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
582,
24,
738
]
],
[
[
582,
25,
1213
],
[
1213,
24,
738
]
],
[
[
582,
64,
1578
],
[
1578,
24,
738
]
],
[
[
582,
24,
848
],
[
848,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Reteplase may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Reteplase may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction... |
DB00819 | DB11110 | 471 | 603 | [
"DDInter15",
"DDInter1115"
] | Acetazolamide | Magnesium citrate | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
471,
24,
603
]
],
[
[
471,
25,
57
],
[
57,
24,
603
]
],
[
[
471,
63,
870
],
[
870,
24,
603
]
],
[
[
471,
64,
1425
],
[
1425,
24,... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Acetazolamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
... | Acetazolamide may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocorti... |
DB06603 | DB14730 | 39 | 1,412 | [
"DDInter1387",
"DDInter264"
] | Panobinostat | Calaspargase pegol | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
39,
24,
1412
]
],
[
[
39,
64,
792
],
[
792,
24,
1412
]
],
[
[
39,
24,
159
],
[
159,
24,
1412
]
],
[
[
39,
25,
868
],
[
868,
24,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
... | Panobinostat may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Laro... |
DB01142 | DB06176 | 1,264 | 1,342 | [
"DDInter593",
"DDInter1616"
] | Doxepin | Romidepsin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1264,
24,
1342
]
],
[
[
1264,
62,
1247
],
[
1247,
23,
1342
]
],
[
[
1264,
63,
956
],
[
956,
24,
1342
]
],
[
[
1264,
24,
1616
],
[
1616... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Nor... |
DB00884 | DB01172 | 1,008 | 416 | [
"DDInter1604",
"DDInter1004"
] | Risedronic acid | Kanamycin | Risedronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
1008,
24,
416
]
],
[
[
1008,
6,
7720
],
[
7720,
46,
416
]
],
[
[
1008,
21,
29196
],
[
29196,
60,
416
]
],
[
[
1008,
40,
1485
],
[
1485... | [
[
[
"Risedronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Risedronic acid",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v}... | Risedronic acid (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Kanamycin (Compound)
Risedronic acid (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Kanamycin (Compound)
Risedronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid may caus... |
DB08903 | DB09330 | 996 | 985 | [
"DDInter170",
"DDInter1352"
] | Bedaquiline | Osimertinib | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
996,
25,
985
]
],
[
[
996,
63,
168
],
[
168,
23,
985
]
],
[
[
996,
62,
112
],
[
112,
23,
985
]
],
[
[
996,
63,
1478
],
[
1478,
2... | [
[
[
"Bedaquiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Bedaquiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezo... | Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Bedaquiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metr... |
DB00581 | DB01044 | 355 | 246 | [
"DDInter1018",
"DDInter809"
] | Lactulose | Gatifloxacin | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Moderate | 1 | [
[
[
355,
24,
246
]
],
[
[
355,
24,
739
],
[
739,
1,
246
]
],
[
[
355,
63,
1176
],
[
1176,
1,
246
]
],
[
[
355,
24,
945
],
[
945,
40,... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (... |
DB00019 | DB00631 | 1,257 | 372 | [
"DDInter1405",
"DDInter405"
] | Pegfilgrastim | Clofarabine | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1257,
24,
372
]
],
[
[
1257,
24,
1426
],
[
1426,
40,
372
]
],
[
[
1257,
25,
1064
],
[
1064,
25,
372
]
],
[
[
1257,
24,
329
],
[
329,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Clofarabine (Compound)
Pegfilgrastim may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction ... |
DB12941 | DB15093 | 466 | 1,654 | [
"DDInter481",
"DDInter1698"
] | Darolutamide | Somapacitan | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
466,
24,
1654
]
],
[
[
466,
62,
351
],
[
351,
24,
1654
]
],
[
[
466,
63,
467
],
[
467,
24,
1654
]
],
[
[
466,
23,
159
],
[
159,
... | [
[
[
"Darolutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Darolutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ribociclib"
],
[... | Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Si... |
DB00059 | DB00963 | 1,560 | 1,263 | [
"DDInter1404",
"DDInter241"
] | Pegaspargase | Bromfenac | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
1560,
24,
1263
]
],
[
[
1560,
24,
935
],
[
935,
40,
1263
]
],
[
[
1560,
24,
1512
],
[
1512,
24,
1263
]
],
[
[
1560,
24,
123
],
[
123,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that co... |
DB00563 | DB00704 | 663 | 267 | [
"DDInter1174",
"DDInter1263"
] | Methotrexate | Naltrexone | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
663,
24,
267
]
],
[
[
663,
6,
4973
],
[
4973,
45,
267
]
],
[
[
663,
7,
2900
],
[
2900,
46,
267
]
],
[
[
663,
18,
15501
],
[
15501,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Naltrexone (Compound)
Methotrexate (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Naltrexone (Compound)
Methotrexate (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Naltrexone (Compound)
Methot... |
DB00467 | DB11921 | 1,467 | 1,019 | [
"DDInter644",
"DDInter492"
] | Enoxacin | Deflazacort | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1467,
25,
1019
]
],
[
[
1467,
24,
1193
],
[
1193,
23,
1019
]
],
[
[
1467,
25,
959
],
[
959,
24,
1019
]
],
[
[
1467,
24,
1021
],
[
1021... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluc... | Enoxacin may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Enoxacin may lead to a major life threatening interaction when taken with Glipizide and Glipizide may cause... |
DB00938 | DB00960 | 455 | 887 | [
"DDInter1635",
"DDInter1471"
] | Salmeterol | Pindolol | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Major | 2 | [
[
[
455,
25,
887
]
],
[
[
455,
63,
726
],
[
726,
1,
887
]
],
[
[
455,
24,
819
],
[
819,
40,
887
]
],
[
[
455,
24,
1148
],
[
1148,
63... | [
[
[
"Salmeterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pindolol"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betaxolol"
],
[
"Betaxolol",
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Betaxolol and Betaxolol (Compound) resembles Pindolol (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Salmet... |
DB01232 | DB09020 | 1,327 | 28 | [
"DDInter1640",
"DDInter212"
] | Saquinavir | Bisacodyl | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1327,
24,
28
]
],
[
[
1327,
7,
7972
],
[
7972,
46,
28
]
],
[
[
1327,
18,
1954
],
[
1954,
57,
28
]
],
[
[
1327,
21,
28666
],
[
28666,
... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Saquinavir",
"{u} (Compound) upregulates {v} (Gene)",
"COL11A1"
],
[
"COL11A1",
"{u} (Gene) is upregulated by {v}... | Saquinavir (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Bisacodyl (Compound)
Saquinavir (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Bisacodyl (Compound)
Saquinavir (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect)... |
DB00095 | DB11767 | 66 | 1,583 | [
"DDInter623",
"DDInter1643"
] | Efalizumab | Sarilumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
66,
24,
1583
]
],
[
[
66,
23,
1461
],
[
1461,
23,
1583
]
],
[
[
66,
24,
850
],
[
850,
24,
1583
]
],
[
[
66,
24,
287
],
[
287,
63... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Bren... |
DB01021 | DB09043 | 674 | 135 | [
"DDInter1861",
"DDInter36"
] | Trichlormethiazide | Albiglutide | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
674,
24,
135
]
],
[
[
674,
62,
126
],
[
126,
23,
135
]
],
[
[
674,
63,
1647
],
[
1647,
23,
135
]
],
[
[
674,
1,
323
],
[
323,
24... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
... | Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and... |
DB00295 | DB01575 | 475 | 1,054 | [
"DDInter1244",
"DDInter1005"
] | Morphine | Kaolin | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
475,
24,
1054
]
],
[
[
475,
24,
17
],
[
17,
23,
1054
]
],
[
[
475,
63,
88
],
[
88,
23,
1054
]
],
[
[
475,
24,
1592
],
[
1592,
62... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
],
[
"Sotalo... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol may cause a... |
DB00938 | DB01284 | 455 | 1,042 | [
"DDInter1635",
"DDInter1782"
] | Salmeterol | Tetracosactide | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Minor | 0 | [
[
[
455,
23,
1042
]
],
[
[
455,
24,
209
],
[
209,
62,
1042
]
],
[
[
455,
24,
480
],
[
480,
23,
1042
]
],
[
[
455,
63,
1052
],
[
1052,
... | [
[
[
"Salmeterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracosactide"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Racepinephrine"
],
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Racepinephrine and Racepinephrine may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol ... |
DB00065 | DB00813 | 581 | 704 | [
"DDInter923",
"DDInter722"
] | Infliximab | Fentanyl | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Moderate | 1 | [
[
[
581,
24,
704
]
],
[
[
581,
24,
371
],
[
371,
40,
704
]
],
[
[
581,
24,
1454
],
[
1454,
1,
704
]
],
[
[
581,
25,
375
],
[
375,
63... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],
[
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Fentanyl (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Sufentanil and Sufentanil (Compound) resembles Fentanyl (Compound)
In... |
DB00673 | DB01227 | 723 | 1,301 | [
"DDInter112",
"DDInter1043"
] | Aprepitant | Levacetylmethadol | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
723,
25,
1301
]
],
[
[
723,
63,
494
],
[
494,
1,
1301
]
],
[
[
723,
23,
307
],
[
307,
1,
1301
]
],
[
[
723,
24,
939
],
[
939,
1,... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
[
"D... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Aprepitant may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Levacetylmethad... |
DB00723 | DB09564 | 1,240 | 1,296 | [
"DDInter1176",
"DDInter930"
] | Methoxamine | Insulin degludec | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1240,
24,
1296
]
],
[
[
1240,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1240,
63,
1645
],
[
1645,
24,
1296
]
],
[
[
1240,
24,
1385
],
[
13... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Metformin a... |
DB00934 | DB09291 | 413 | 741 | [
"DDInter1124",
"DDInter1615"
] | Maprotiline | Rolapitant | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
413,
24,
741
]
],
[
[
413,
24,
1264
],
[
1264,
24,
741
]
],
[
[
413,
40,
847
],
[
847,
24,
741
]
],
[
[
413,
25,
478
],
[
478,
2... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Maprotiline (Compound) resembles Atomoxetine (Compound) and Atomoxetine may cause a moderate interaction that could e... |
DB00425 | DB01234 | 558 | 1,220 | [
"DDInter1970",
"DDInter513"
] | Zolpidem | Dexamethasone | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
558,
24,
1220
]
],
[
[
558,
10,
11594
],
[
11594,
44,
1220
]
],
[
[
558,
6,
21998
],
[
21998,
45,
1220
]
],
[
[
558,
21,
29879
],
[
29... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Zolpidem",
"{u} (Compound) palliates {v} (Disease)",
"multiple sclerosis"
],
[
"multiple sclerosis",
"{u} (Dise... | Zolpidem (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Dexamethasone (Compound)
Zolpidem (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Dexamethasone (Compound)
Zolpidem (Compound) causes Trauma (Side Effect) and Trauma (Side Effect) is ... |
DB01174 | DB06273 | 697 | 980 | [
"DDInter1442",
"DDInter1824"
] | Phenobarbital | Tocilizumab | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
697,
24,
980
]
],
[
[
697,
24,
309
],
[
309,
24,
980
]
],
[
[
697,
63,
1031
],
[
1031,
24,
980
]
],
[
[
697,
64,
629
],
[
629,
2... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Theophylline... |
DB00420 | DB09278 | 508 | 852 | [
"DDInter1532",
"DDInter24"
] | Promazine | Activated charcoal | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
508,
24,
852
]
],
[
[
508,
40,
21
],
[
21,
24,
852
]
],
[
[
508,
24,
127
],
[
127,
24,
852
]
],
[
[
508,
63,
1647
],
[
1647,
24,... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Promazine",
"{u} (Compound) resembles {v} (Compound)",
"Amitriptyline"
],
[
"Amitriptyline",
"{u} may cau... | Promazine (Compound) resembles Amitriptyline (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction th... |
DB00163 | DB11714 | 1,461 | 1,316 | [
"DDInter1943",
"DDInter610"
] | Vitamin E | Durvalumab | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Minor | 0 | [
[
[
1461,
23,
1316
]
],
[
[
1461,
23,
167
],
[
167,
24,
1316
]
],
[
[
1461,
23,
270
],
[
270,
63,
1316
]
],
[
[
1461,
62,
58
],
[
58,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Durvalumab"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrocortisone"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Durvalumab
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab and Ocr... |
DB00635 | DB06203 | 1,573 | 1,002 | [
"DDInter1515",
"DDInter51"
] | Prednisone | Alogliptin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1573,
24,
1002
]
],
[
[
1573,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1573,
6,
8374
],
[
8374,
45,
1002
]
],
[
[
1573,
21,
28873
],
[
28... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Prednisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alogliptin (Compound)
Prednisone (Compound) causes Pancreatitis (Side Effect) and Panc... |
DB00679 | DB01191 | 684 | 1,039 | [
"DDInter1796",
"DDInter518"
] | Thioridazine | Dexfenfluramine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
684,
25,
1039
]
],
[
[
684,
6,
5744
],
[
5744,
45,
1039
]
],
[
[
684,
18,
4360
],
[
4360,
57,
1039
]
],
[
[
684,
25,
1045
],
[
1045,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"HTR2C"
],
[
"HTR2C",
"{u} (Gene) is bound by {v} (Compound)",
"... | Thioridazine (Compound) binds HTR2C (Gene) and HTR2C (Gene) is bound by Dexfenfluramine (Compound)
Thioridazine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Dexfenfluramine (Compound)
Thioridazine may lead to a major life threatening interaction when taken with Dacomitinib and Dacomitinib ... |
DB00682 | DB00754 | 126 | 157 | [
"DDInter1951",
"DDInter696"
] | Warfarin | Ethotoin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
126,
24,
157
]
],
[
[
126,
25,
759
],
[
759,
40,
157
]
],
[
[
126,
1,
11305
],
[
11305,
40,
157
]
],
[
[
126,
6,
10215
],
[
10215,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primidone"
],
[
"Primidone",
... | Warfarin may lead to a major life threatening interaction when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Warfarin (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Ethotoin (Compound)
Warfarin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by... |
DB00575 | DB00692 | 1,020 | 274 | [
"DDInter412",
"DDInter1448"
] | Clonidine | Phentolamine | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
1020,
24,
274
]
],
[
[
1020,
6,
5372
],
[
5372,
45,
274
]
],
[
[
1020,
5,
11590
],
[
11590,
49,
274
]
],
[
[
1020,
21,
29118
],
[
2911... | [
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Clonidine",
"{u} (Compound) binds {v} (Gene)",
"ADRA2A"
],
[
"ADRA2A",
"{u} (Gene) is bound by {v} (Compound)",... | Clonidine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Phentolamine (Compound)
Clonidine (Compound) treats hypertension (Disease) and hypertension (Disease) is palliated by Phentolamine (Compound)
Clonidine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolami... |
DB00570 | DB14723 | 147 | 159 | [
"DDInter1936",
"DDInter1026"
] | Vinblastine | Larotrectinib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
147,
24,
159
]
],
[
[
147,
24,
1375
],
[
1375,
24,
159
]
],
[
[
147,
62,
63
],
[
63,
24,
159
]
],
[
[
147,
23,
307
],
[
307,
24,... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Vinblastine may cause a minor interaction that can limit clinical effects when taken with Teniposide and Tenip... |
DB00099 | DB01042 | 440 | 1,307 | [
"DDInter735",
"DDInter1144"
] | Filgrastim | Melphalan | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Moderate | 1 | [
[
[
440,
24,
1307
]
],
[
[
440,
24,
168
],
[
168,
23,
1307
]
],
[
[
440,
24,
4
],
[
4,
63,
1307
]
],
[
[
440,
24,
869
],
[
869,
24,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Melphalan
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinat... |
DB00286 | DB01285 | 380 | 708 | [
"DDInter439",
"DDInter445"
] | Conjugated estrogens | Corticotropin | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
380,
24,
708
]
],
[
[
380,
23,
771
],
[
771,
62,
708
]
],
[
[
380,
63,
245
],
[
245,
24,
708
]
],
[
[
380,
24,
170
],
[
170,
24,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyalur... | Conjugated estrogens may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00738 | DB01118 | 485 | 33 | [
"DDInter1420",
"DDInter76"
] | Pentamidine | Amiodarone | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Major | 2 | [
[
[
485,
25,
33
]
],
[
[
485,
25,
540
],
[
540,
1,
33
]
],
[
[
485,
6,
7950
],
[
7950,
45,
33
]
],
[
[
485,
18,
9650
],
[
9650,
46,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
]
],
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
"{... | Pentamidine may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Pentamidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Pentamidine (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upreg... |
DB00903 | DB09133 | 1,680 | 1,527 | [
"DDInter686",
"DDInter965"
] | Etacrynic acid | Iothalamic acid | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
1680,
24,
1527
]
],
[
[
1680,
63,
1648
],
[
1648,
24,
1527
]
],
[
[
1680,
63,
589
],
[
589,
25,
1527
]
],
[
[
1680,
24,
848
],
[
848,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Cispla... |
DB00604 | DB00845 | 1,425 | 1,490 | [
"DDInter385",
"DDInter406"
] | Cisapride | Clofazimine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Major | 2 | [
[
[
1425,
25,
1490
]
],
[
[
1425,
6,
8374
],
[
8374,
45,
1490
]
],
[
[
1425,
23,
112
],
[
112,
62,
1490
]
],
[
[
1425,
25,
1250
],
[
1250,... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofazimine"
]
],
[
[
"Cisapride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Clofazim... | Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clofazimine (Compound)
Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Clofazimine
Cisapride may le... |
DB00254 | DB01602 | 964 | 339 | [
"DDInter598",
"DDInter159"
] | Doxycycline | Bacampicillin | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal ac... | Moderate | 1 | [
[
[
964,
24,
339
]
],
[
[
964,
24,
703
],
[
703,
1,
339
]
],
[
[
964,
24,
950
],
[
950,
40,
339
]
],
[
[
964,
24,
115
],
[
115,
63,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacampicillin"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbenicillin"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Carbenicillin and Carbenicillin (Compound) resembles Bacampicillin (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembles Bacampici... |
DB01218 | DB08903 | 1,493 | 996 | [
"DDInter852",
"DDInter170"
] | Halofantrine | Bedaquiline | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
1493,
25,
996
]
],
[
[
1493,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1493,
21,
29282
],
[
29282,
60,
996
]
],
[
[
1493,
62,
112
],
[
112,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Halofantrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Be... | Halofantrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Halofantrine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Halofantrine may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00321 | DB01064 | 21 | 1,148 | [
"DDInter78",
"DDInter987"
] | Amitriptyline | Isoprenaline | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
21,
24,
1148
]
],
[
[
21,
25,
1636
],
[
1636,
24,
1148
]
],
[
[
21,
24,
480
],
[
480,
24,
1148
]
],
[
[
21,
18,
1954
],
[
1954,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylephrine"
],
[
... | Amitriptyline may lead to a major life threatening interaction when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formote... |
DB00726 | DB09488 | 1,164 | 103 | [
"DDInter1876",
"DDInter23"
] | Trimipramine | Acrivastine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1164,
24,
103
]
],
[
[
1164,
1,
1405
],
[
1405,
24,
103
]
],
[
[
1164,
63,
85
],
[
85,
24,
103
]
],
[
[
1164,
35,
1264
],
[
1264,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Trimipramine",
"{u} (Compound) resembles {v} (Compound)",
"Cyclobenzaprine"
],
[
"Cyclobenzaprine",
"{u} may ... | Trimipramine (Compound) resembles Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction... |
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