drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00781 | DB01249 | 1,481 | 258 | [
"DDInter1489",
"DDInter958"
] | Polymyxin B | Iodixanol | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
1481,
25,
258
]
],
[
[
1481,
25,
497
],
[
497,
1,
258
]
],
[
[
1481,
21,
28719
],
[
28719,
60,
258
]
],
[
[
1481,
24,
242
],
[
242,
... | [
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compo... | Polymyxin B may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Polymyxin B (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Iodixanol (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases... |
DB01618 | DB11186 | 776 | 1,609 | [
"DDInter1239",
"DDInter1427"
] | Molindone | Pentoxyverine | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
776,
24,
1609
]
],
[
[
776,
63,
104
],
[
104,
24,
1609
]
],
[
[
776,
24,
649
],
[
649,
24,
1609
]
],
[
[
776,
64,
1311
],
[
1311,
... | [
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Molindone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Molindone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and C... |
DB00647 | DB01612 | 675 | 1,637 | [
"DDInter528",
"DDInter92"
] | Dextropropoxyphene | Amyl Nitrite | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
675,
24,
1637
]
],
[
[
675,
40,
358
],
[
358,
24,
1637
]
],
[
[
675,
64,
475
],
[
475,
24,
1637
]
],
[
[
675,
25,
401
],
[
401,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{... | Dextropropoxyphene (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Dextropropoxyphene may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that co... |
DB01072 | DB06335 | 915 | 761 | [
"DDInter129",
"DDInter1646"
] | Atazanavir | Saxagliptin | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
915,
24,
761
]
],
[
[
915,
6,
10417
],
[
10417,
45,
761
]
],
[
[
915,
21,
28722
],
[
28722,
60,
761
]
],
[
[
915,
25,
1491
],
[
1491,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Atazanavir",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound)",
... | Atazanavir (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saxagliptin (Compound)
Atazanavir (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Atazanavir may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a ... |
DB00465 | DB00945 | 886 | 1,479 | [
"DDInter1010",
"DDInter20"
] | Ketorolac | Acetylsalicylic acid | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Major | 2 | [
[
[
886,
25,
1479
]
],
[
[
886,
40,
345
],
[
345,
40,
1479
]
],
[
[
886,
7,
2900
],
[
2900,
45,
1479
]
],
[
[
886,
6,
10522
],
[
10522,
... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Ketorolac",
"{u} (Compound) resembles {v} (Compound)",
"Salsalate"
],
[
"Salsalate",
"{u} (Compound) resembles {v} (Co... | Ketorolac (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Acetylsalicylic acid (Compound)
Ketorolac (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is bound by Acetylsalicylic acid (Compound)
Ketorolac (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Acetylsalicylic acid (C... |
DB09133 | DB09340 | 1,527 | 1,013 | [
"DDInter965",
"DDInter1895"
] | Iothalamic acid | Tyropanoic acid | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
1527,
24,
1013
]
],
[
[
1527,
24,
1586
],
[
1586,
24,
1013
]
],
[
[
1527,
63,
819
],
[
819,
24,
1013
]
],
[
[
1527,
24,
1586
],
[
1586... | [
[
[
"Iothalamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Iothalamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipin... | Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine and Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB09030 | DB14276 | 840 | 1,631 | [
"DDInter1945",
"DDInter1892"
] | Vorapaxar | Turmeric | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
840,
23,
1631
]
],
[
[
840,
64,
20
],
[
20,
23,
1631
]
],
[
[
840,
25,
1421
],
[
1421,
23,
1631
]
],
[
[
840,
63,
578
],
[
578,
... | [
[
[
"Vorapaxar",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
]
],
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenecteplase",... | Vorapaxar may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Vorapaxar may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a minor interacti... |
DB00783 | DB14723 | 1,438 | 159 | [
"DDInter679",
"DDInter1026"
] | Estradiol | Larotrectinib | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1438,
24,
159
]
],
[
[
1438,
24,
98
],
[
98,
24,
159
]
],
[
[
1438,
63,
597
],
[
597,
24,
159
]
],
[
[
1438,
1,
35
],
[
35,
24,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chlo... |
DB00877 | DB01076 | 629 | 700 | [
"DDInter1678",
"DDInter133"
] | Sirolimus | Atorvastatin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
629,
24,
700
]
],
[
[
629,
64,
1080
],
[
1080,
1,
700
]
],
[
[
629,
24,
788
],
[
788,
1,
700
]
],
[
[
629,
6,
4973
],
[
4973,
45... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan... | Sirolimus may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Sirolimus... |
DB00099 | DB00970 | 440 | 0 | [
"DDInter735",
"DDInter466"
] | Filgrastim | Dactinomycin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Moderate | 1 | [
[
[
440,
24,
0
]
],
[
[
440,
24,
384
],
[
384,
63,
0
]
],
[
[
440,
24,
611
],
[
611,
24,
0
]
],
[
[
440,
63,
1648
],
[
1648,
24,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dactinomycin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine and Dac... |
DB08889 | DB11989 | 350 | 1,434 | [
"DDInter299",
"DDInter183"
] | Carfilzomib | Benznidazole | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
350,
24,
1434
]
],
[
[
350,
63,
788
],
[
788,
24,
1434
]
],
[
[
350,
25,
375
],
[
375,
24,
1434
]
],
[
[
350,
24,
148
],
[
148,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Carfilzomib may lead to a major life threatening interaction when taken with Certolizumab pegol and Certo... |
DB00328 | DB00531 | 831 | 450 | [
"DDInter921",
"DDInter456"
] | Indomethacin | Cyclophosphamide | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Minor | 0 | [
[
[
831,
23,
450
]
],
[
[
831,
6,
6017
],
[
6017,
45,
450
]
],
[
[
831,
21,
28725
],
[
28725,
60,
450
]
],
[
[
831,
25,
256
],
[
256,
... | [
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cyclophosphamide"
]
],
[
[
"Indomethacin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Com... | Indomethacin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cyclophosphamide (Compound)
Indomethacin (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Cyclophosphamide (Compound)
Indomethacin may lead to a major life threatening interaction when taken with Prasugrel ... |
DB00451 | DB11827 | 542 | 433 | [
"DDInter1064",
"DDInter669"
] | Levothyroxine | Ertugliflozin | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
542,
24,
433
]
],
[
[
542,
23,
1121
],
[
1121,
24,
433
]
],
[
[
542,
24,
959
],
[
959,
24,
433
]
],
[
[
542,
63,
362
],
[
362,
2... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bisoprolol"
],
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Bisoprolol and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and ... |
DB09080 | DB11642 | 144 | 938 | [
"DDInter1331",
"DDInter1480"
] | Olodaterol | Pitolisant | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
144,
24,
938
]
],
[
[
144,
63,
600
],
[
600,
24,
938
]
],
[
[
144,
24,
927
],
[
927,
63,
938
]
],
[
[
144,
24,
659
],
[
659,
24,... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Enc... |
DB00427 | DB00981 | 1,233 | 1,528 | [
"DDInter1879",
"DDInter1462"
] | Triprolidine | Physostigmine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1233,
24,
1528
]
],
[
[
1233,
63,
508
],
[
508,
24,
1528
]
],
[
[
1233,
24,
87
],
[
87,
24,
1528
]
],
[
[
1233,
24,
1511
],
[
1511,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Am... |
DB00008 | DB00060 | 491 | 912 | [
"DDInter1407",
"DDInter947"
] | Peginterferon alfa-2a | Interferon beta-1a | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Moderate | 1 | [
[
[
491,
24,
912
]
],
[
[
491,
24,
1439
],
[
1439,
63,
912
]
],
[
[
491,
25,
876
],
[
876,
63,
912
]
],
[
[
491,
24,
305
],
[
305,
2... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a
Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Tizani... |
DB00059 | DB08901 | 1,560 | 1,468 | [
"DDInter1404",
"DDInter1492"
] | Pegaspargase | Ponatinib | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1560,
24,
1468
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[
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1560,
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],
[
478,
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[
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1560,
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[
987,
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[
[
1560,
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268
],
[
268,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD ... |
DB00401 | DB11921 | 84 | 1,019 | [
"DDInter1298",
"DDInter492"
] | Nisoldipine | Deflazacort | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
84,
24,
1019
]
],
[
[
84,
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],
[
1619,
63,
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]
],
[
[
84,
24,
629
],
[
629,
24,
1019
]
],
[
[
84,
40,
1428
],
[
1428,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Siroli... |
DB00988 | DB01278 | 817 | 1,021 | [
"DDInter584",
"DDInter1506"
] | Dopamine | Pramlintide | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
817,
24,
1021
]
],
[
[
817,
63,
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],
[
1466,
24,
1021
]
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[
[
817,
24,
1296
],
[
1296,
63,
1021
]
],
[
[
817,
40,
532
],
[
532,
... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylpropanolamine"
],
... | Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamine and Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Insuli... |
DB00656 | DB11186 | 827 | 1,609 | [
"DDInter1851",
"DDInter1427"
] | Trazodone | Pentoxyverine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
827,
24,
1609
]
],
[
[
827,
1,
623
],
[
623,
24,
1609
]
],
[
[
827,
24,
104
],
[
104,
24,
1609
]
],
[
[
827,
63,
999
],
[
999,
2... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Trazodone",
"{u} (Compound) resembles {v} (Compound)",
"Quetiapine"
],
[
"Quetiapine",
"{u} may cause a modera... | Trazodone (Compound) resembles Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that ... |
DB01365 | DB09043 | 280 | 135 | [
"DDInter1151",
"DDInter36"
] | Mephentermine | Albiglutide | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
280,
24,
135
]
],
[
[
280,
63,
1647
],
[
1647,
23,
135
]
],
[
[
280,
63,
176
],
[
176,
24,
135
]
],
[
[
280,
74,
73
],
[
73,
24,... | [
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
... | Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and... |
DB00041 | DB00831 | 1,648 | 1,178 | [
"DDInter38",
"DDInter1866"
] | Aldesleukin | Trifluoperazine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1648,
24,
1178
]
],
[
[
1648,
25,
695
],
[
695,
40,
1178
]
],
[
[
1648,
24,
146
],
[
146,
40,
1178
]
],
[
[
1648,
24,
9
],
[
9,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Cloz... | Aldesleukin may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine (Compound) resembles Trifluoperazine (Compound)
A... |
DB00213 | DB00563 | 837 | 663 | [
"DDInter1388",
"DDInter1174"
] | Pantoprazole | Methotrexate | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Major | 2 | [
[
[
837,
25,
663
]
],
[
[
837,
6,
4973
],
[
4973,
45,
663
]
],
[
[
837,
21,
29215
],
[
29215,
60,
663
]
],
[
[
837,
24,
126
],
[
126,
... | [
[
[
"Pantoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
]
],
[
[
"Pantoprazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Met... | Pantoprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Pantoprazole (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Methotrexate (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Warfarin ... |
DB14443 | DB15091 | 987 | 676 | [
"DDInter1931",
"DDInter1901"
] | Vibrio cholerae CVD 103-HgR strain live antigen | Upadacitinib | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
987,
24,
676
]
],
[
[
987,
63,
1184
],
[
1184,
25,
676
]
],
[
[
987,
24,
994
],
[
994,
25,
676
]
],
[
[
987,
63,
1184
],
[
1184,
... | [
[
[
"Vibrio cholerae CVD 103-HgR strain live antigen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Vibrio cholerae CVD 103-HgR strain live antigen",
"{u} may cause a moderate interaction that could ... | Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could ... |
DB01176 | DB11130 | 537 | 407 | [
"DDInter453",
"DDInter1344"
] | Cyclizine | Opium | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
537,
24,
407
]
],
[
[
537,
63,
558
],
[
558,
24,
407
]
],
[
[
537,
24,
1190
],
[
1190,
24,
407
]
],
[
[
537,
24,
418
],
[
418,
6... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
],
[
"Zolp... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Opium
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Ketamine and Ketamine may cause ... |
DB00056 | DB00065 | 816 | 581 | [
"DDInter814",
"DDInter923"
] | Gemtuzumab ozogamicin | Infliximab | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions . Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory... | Major | 2 | [
[
[
816,
25,
581
]
],
[
[
816,
24,
221
],
[
221,
63,
581
]
],
[
[
816,
24,
912
],
[
912,
24,
581
]
],
[
[
816,
25,
1137
],
[
1137,
6... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 an... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Infliximab
Gemtuzumab ozogam... |
DB00250 | DB12332 | 10 | 1,619 | [
"DDInter475",
"DDInter1626"
] | Dapsone | Rucaparib | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
10,
24,
1619
]
],
[
[
10,
23,
307
],
[
307,
23,
1619
]
],
[
[
10,
24,
112
],
[
112,
23,
1619
]
],
[
[
10,
24,
309
],
[
309,
24,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Dapsone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modaf... | Dapsone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole ma... |
DB01042 | DB06168 | 1,307 | 1,531 | [
"DDInter1144",
"DDInter281"
] | Melphalan | Canakinumab | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
1307,
24,
1531
]
],
[
[
1307,
23,
1193
],
[
1193,
62,
1531
]
],
[
[
1307,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
1307,
63,
377
],
[
377... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Melphalan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Melphalan may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vita... |
DB00595 | DB00774 | 1,545 | 1,577 | [
"DDInter1374",
"DDInter889"
] | Oxytetracycline | Hydroflumethiazide | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Minor | 0 | [
[
[
1545,
23,
1577
]
],
[
[
1545,
23,
359
],
[
359,
40,
1577
]
],
[
[
1545,
23,
504
],
[
504,
1,
1577
]
],
[
[
1545,
40,
1620
],
[
1620,
... | [
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chlorothiazid... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazide (Co... |
DB00305 | DB11627 | 377 | 1,367 | [
"DDInter1232",
"DDInter860"
] | Mitomycin | Hepatitis B Vaccine (Recombinant) | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
377,
24,
1367
]
],
[
[
377,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
377,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
377,
24,
259
],
[
259,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesl... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Mitomycin may lead to a major life threatening interaction when taken with Cladribine an... |
DB00603 | DB08912 | 303 | 1,040 | [
"DDInter1137",
"DDInter462"
] | Medroxyprogesterone acetate | Dabrafenib | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Major | 2 | [
[
[
303,
25,
1040
]
],
[
[
303,
6,
3486
],
[
3486,
45,
1040
]
],
[
[
303,
7,
3932
],
[
3932,
46,
1040
]
],
[
[
303,
18,
15601
],
[
15601,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dabrafenib"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound ... | Medroxyprogesterone acetate (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dabrafenib (Compound)
Medroxyprogesterone acetate (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Dabrafenib (Compound)
Medroxyprogesterone acetate (Compound) downregulates DHRS7 (Gene) and DHRS7 (Gene) is up... |
DB00444 | DB01118 | 63 | 33 | [
"DDInter1765",
"DDInter76"
] | Teniposide | Amiodarone | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
63,
24,
33
]
],
[
[
63,
24,
540
],
[
540,
1,
33
]
],
[
[
63,
6,
7524
],
[
7524,
45,
33
]
],
[
[
63,
7,
8606
],
[
8606,
46,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Teniposide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Amiodarone (Compound)
Teniposide (Compound) upregulates ALDOC (Gene) and ALDOC (Gene) ... |
DB00502 | DB09472 | 1,300 | 1,383 | [
"DDInter853",
"DDInter1693"
] | Haloperidol | Sodium sulfate | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1300,
24,
1383
]
],
[
[
1300,
25,
609
],
[
609,
24,
1383
]
],
[
[
1300,
64,
521
],
[
521,
24,
1383
]
],
[
[
1300,
63,
1466
],
[
1466,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"... | Haloperidol may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Haloperidol may lead to a major life threatening interaction when taken with Goserelin and Goserelin may cause a m... |
DB00004 | DB06168 | 669 | 1,531 | [
"DDInter499",
"DDInter281"
] | Denileukin diftitox | Canakinumab | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
669,
24,
1531
]
],
[
[
669,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
669,
24,
599
],
[
599,
24,
1531
]
],
[
[
669,
25,
770
],
[
770,
... | [
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubercul... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Denileukin diftitox may cause a moderate inter... |
DB00603 | DB11834 | 303 | 1,303 | [
"DDInter1137",
"DDInter849"
] | Medroxyprogesterone acetate | Guselkumab | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
303,
24,
1303
]
],
[
[
303,
63,
58
],
[
58,
24,
1303
]
],
[
[
303,
24,
259
],
[
259,
24,
1303
]
],
[
[
303,
23,
700
],
[
700,
24... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when ... |
DB01281 | DB10989 | 881 | 496 | [
"DDInter5",
"DDInter858"
] | Abatacept | Hepatitis A Vaccine | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
881,
24,
496
]
],
[
[
881,
24,
4
],
[
4,
24,
496
]
],
[
[
881,
25,
976
],
[
976,
24,
496
]
],
[
[
881,
24,
270
],
[
270,
63,
... | [
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Abatacept may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Abatacept may lead to a major life threatening interaction when taken with... |
DB00502 | DB00719 | 1,300 | 1,219 | [
"DDInter853",
"DDInter149"
] | Haloperidol | Azatadine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1300,
24,
1219
]
],
[
[
1300,
63,
13
],
[
13,
24,
1219
]
],
[
[
1300,
24,
830
],
[
830,
1,
1219
]
],
[
[
1300,
6,
8374
],
[
8374,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine... |
DB00357 | DB06717 | 1,051 | 875 | [
"DDInter71",
"DDInter778"
] | Aminoglutethimide | Fosaprepitant | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
1051,
24,
875
]
],
[
[
1051,
24,
723
],
[
723,
1,
875
]
],
[
[
1051,
21,
28680
],
[
28680,
60,
875
]
],
[
[
1051,
24,
466
],
[
466,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Aminoglutethimide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Fosaprepitant (Compound)
Aminoglutethimide may cause a mode... |
DB00601 | DB00852 | 453 | 1,445 | [
"DDInter1073",
"DDInter1545"
] | Linezolid | Pseudoephedrine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Major | 2 | [
[
[
453,
25,
1445
]
],
[
[
453,
64,
73
],
[
73,
24,
1445
]
],
[
[
453,
25,
22
],
[
22,
40,
1445
]
],
[
[
453,
6,
9053
],
[
9053,
45,... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phentermine"
],
[
"Phentermine",
"... | Linezolid may lead to a major life threatening interaction when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Linezolid may lead to a major life threatening interaction when taken with Ephedrine and Ephedrine (Compound) resembles P... |
DB00745 | DB12332 | 307 | 1,619 | [
"DDInter1236",
"DDInter1626"
] | Modafinil | Rucaparib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Minor | 0 | [
[
[
307,
23,
1619
]
],
[
[
307,
23,
1135
],
[
1135,
23,
1619
]
],
[
[
307,
23,
309
],
[
309,
24,
1619
]
],
[
[
307,
62,
1419
],
[
1419,
... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rucaparib"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Nal... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Modafinil may cause a minor interaction that can limit clinical effects when taken with Ixabepilone and Ixabepilone may ... |
DB00507 | DB01067 | 316 | 959 | [
"DDInter1299",
"DDInter826"
] | Nitazoxanide | Glipizide | Nitazoxanide belongs to the class of drugs known as _thiazolides_. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses.... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
316,
24,
959
]
],
[
[
316,
63,
245
],
[
245,
40,
959
]
],
[
[
316,
24,
1411
],
[
1411,
1,
959
]
],
[
[
316,
18,
1918
],
[
1918,
... | [
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Comp... |
DB00454 | DB00747 | 1,349 | 1,442 | [
"DDInter1150",
"DDInter1647"
] | Meperidine | Scopolamine | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1349,
24,
1442
]
],
[
[
1349,
63,
19
],
[
19,
24,
1442
]
],
[
[
1349,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
1349,
24,
543
],
[
543,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Meperidine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Scopolamine... |
DB06694 | DB09082 | 31 | 659 | [
"DDInter1952",
"DDInter1934"
] | Xylometazoline (nasal) | Vilanterol | Xylometazoline is an alkylbenzene. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
31,
24,
659
]
],
[
[
31,
63,
1161
],
[
1161,
24,
659
]
],
[
[
31,
24,
1663
],
[
1663,
63,
659
]
],
[
[
31,
24,
643
],
[
643,
24,... | [
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
],
... | Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Xy... |
DB00350 | DB00862 | 1,214 | 1,005 | [
"DDInter1226",
"DDInter1918"
] | Minoxidil | Vardenafil | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Moderate | 1 | [
[
[
1214,
24,
1005
]
],
[
[
1214,
24,
1344
],
[
1344,
63,
1005
]
],
[
[
1214,
24,
1061
],
[
1061,
24,
1005
]
],
[
[
1214,
24,
1344
],
[
13... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vardenafil"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and ... |
DB00916 | DB11730 | 112 | 351 | [
"DDInter1202",
"DDInter1588"
] | Metronidazole | Ribociclib | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Minor | 0 | [
[
[
112,
23,
351
]
],
[
[
112,
23,
1247
],
[
1247,
23,
351
]
],
[
[
112,
63,
479
],
[
479,
23,
351
]
],
[
[
112,
24,
310
],
[
310,
2... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ribociclib"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Donepez... |
DB06717 | DB12941 | 875 | 466 | [
"DDInter778",
"DDInter481"
] | Fosaprepitant | Darolutamide | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
875,
23,
466
]
],
[
[
875,
63,
600
],
[
600,
23,
466
]
],
[
[
875,
24,
351
],
[
351,
23,
466
]
],
[
[
875,
25,
484
],
[
484,
23,... | [
[
[
"Fosaprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib an... |
DB00802 | DB01619 | 1,322 | 830 | [
"DDInter43",
"DDInter1441"
] | Alfentanil | Phenindamine | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1322,
24,
830
]
],
[
[
1322,
24,
537
],
[
537,
40,
830
]
],
[
[
1322,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1322,
63,
13
],
[
13,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound)
... |
DB00263 | DB01067 | 1,029 | 959 | [
"DDInter1727",
"DDInter826"
] | Sulfisoxazole | Glipizide | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1029,
24,
959
]
],
[
[
1029,
63,
245
],
[
245,
40,
959
]
],
[
[
1029,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1029,
6,
6017
],
[
6017,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Co... |
DB00208 | DB05541 | 1,018 | 801 | [
"DDInter1804",
"DDInter239"
] | Ticlopidine | Brivaracetam | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Minor | 0 | [
[
[
1018,
23,
801
]
],
[
[
1018,
25,
477
],
[
477,
23,
801
]
],
[
[
1018,
24,
126
],
[
126,
23,
801
]
],
[
[
1018,
24,
506
],
[
506,
... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Brivaracetam"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
],
[
"Cilostaz... | Ticlopidine may lead to a major life threatening interaction when taken with Cilostazol and Cilostazol may cause a minor interaction that can limit clinical effects when taken with Brivaracetam
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a ... |
DB00741 | DB08882 | 167 | 1,281 | [
"DDInter885",
"DDInter1070"
] | Hydrocortisone | Linagliptin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
167,
24,
1281
]
],
[
[
167,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
167,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
167,
21,
28966
],
[
28966,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Hydrocortisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Hydrocortisone (Compound) causes Upper respiratory tract... |
DB00843 | DB09078 | 479 | 1,228 | [
"DDInter583",
"DDInter1036"
] | Donepezil | Lenvatinib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
479,
24,
1228
]
],
[
[
479,
24,
112
],
[
112,
23,
1228
]
],
[
[
479,
23,
609
],
[
609,
24,
1228
]
],
[
[
479,
24,
1264
],
[
1264,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Donepezil may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Cl... |
DB00899 | DB01041 | 411 | 770 | [
"DDInter1579",
"DDInter1789"
] | Remifentanil | Thalidomide | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
411,
24,
770
]
],
[
[
411,
21,
29425
],
[
29425,
60,
770
]
],
[
[
411,
24,
849
],
[
849,
63,
770
]
],
[
[
411,
63,
1614
],
[
1614,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Remifentanil",
"{u} (Compound) causes {v} (Side Effect)",
"Myocardial ischaemia"
],
[
"Myocardial ischaemia",
... | Remifentanil (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate disea... |
DB06209 | DB06441 | 256 | 936 | [
"DDInter1508",
"DDInter283"
] | Prasugrel | Cangrelor | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Major | 2 | [
[
[
256,
25,
936
]
],
[
[
256,
23,
1631
],
[
1631,
62,
936
]
],
[
[
256,
64,
97
],
[
97,
24,
936
]
],
[
[
256,
63,
383
],
[
383,
24,... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cangrelor"
]
],
[
[
"Prasugrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",
... | Prasugrel may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Prasugrel may lead to a major life threatening interaction when taken with Oxaprozin and Oxaprozin may cause a moderate in... |
DB00867 | DB01259 | 1,052 | 392 | [
"DDInter1606",
"DDInter1024"
] | Ritodrine | Lapatinib | Adrenergic beta-agonist used to control premature labor. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1052,
24,
392
]
],
[
[
1052,
24,
918
],
[
918,
24,
392
]
],
[
[
1052,
63,
1010
],
[
1010,
24,
392
]
],
[
[
1052,
62,
167
],
[
167,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Meflo... |
DB09280 | DB11978 | 1,604 | 124 | [
"DDInter1101",
"DDInter822"
] | Lumacaftor | Glasdegib | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1604,
25,
124
]
],
[
[
1604,
64,
1135
],
[
1135,
23,
124
]
],
[
[
1604,
25,
466
],
[
466,
62,
124
]
],
[
[
1604,
63,
79
],
[
79,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Lumacaftor may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Lumacaftor may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interact... |
DB00446 | DB00552 | 597 | 1,238 | [
"DDInter351",
"DDInter1425"
] | Chloramphenicol | Pentostatin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
597,
24,
1238
]
],
[
[
597,
63,
1083
],
[
1083,
40,
1238
]
],
[
[
597,
24,
1426
],
[
1426,
1,
1238
]
],
[
[
597,
24,
1477
],
[
1477,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) resembles Pentostatin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Pento... |
DB01030 | DB05273 | 869 | 507 | [
"DDInter1835",
"DDInter1638"
] | Topotecan | Samarium (153Sm) lexidronam | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
869,
25,
507
]
],
[
[
869,
24,
248
],
[
248,
24,
507
]
],
[
[
869,
63,
563
],
[
563,
24,
507
]
],
[
[
869,
24,
270
],
[
270,
63,... | [
[
[
"Topotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Topotecan may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB08881 | DB11796 | 868 | 1,612 | [
"DDInter1925",
"DDInter786"
] | Vemurafenib | Fostemsavir | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Major | 2 | [
[
[
868,
25,
1612
]
],
[
[
868,
63,
1051
],
[
1051,
23,
1612
]
],
[
[
868,
24,
98
],
[
98,
23,
1612
]
],
[
[
868,
24,
1476
],
[
1476,
... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
"... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Somatr... |
DB00005 | DB15035 | 1,057 | 503 | [
"DDInter687",
"DDInter1959"
] | Etanercept | Zanubrutinib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1057,
25,
503
]
],
[
[
1057,
24,
1430
],
[
1430,
24,
503
]
],
[
[
1057,
25,
1683
],
[
1683,
24,
503
]
],
[
[
1057,
25,
39
],
[
39,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Etanercept may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab ma... |
DB01234 | DB01324 | 1,220 | 178 | [
"DDInter513",
"DDInter1490"
] | Dexamethasone | Polythiazide | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
1220,
24,
178
]
],
[
[
1220,
63,
674
],
[
674,
40,
178
]
],
[
[
1220,
21,
28835
],
[
28835,
60,
178
]
],
[
[
1220,
63,
126
],
[
126,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Dexamethasone (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Dexameth... |
DB06077 | DB09046 | 879 | 1,094 | [
"DDInter1102",
"DDInter1201"
] | Lumateperone | Metreleptin | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Major | 2 | [
[
[
879,
25,
1094
]
],
[
[
879,
63,
1254
],
[
1254,
24,
1094
]
],
[
[
879,
25,
384
],
[
384,
63,
1094
]
],
[
[
879,
24,
214
],
[
214,
... | [
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metreleptin"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],
[
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Lumateperone may lead to a major life threatening interaction when taken with Idelalisib and Id... |
DB01224 | DB06335 | 623 | 761 | [
"DDInter1553",
"DDInter1646"
] | Quetiapine | Saxagliptin | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
623,
24,
761
]
],
[
[
623,
6,
7524
],
[
7524,
45,
761
]
],
[
[
623,
21,
28966
],
[
28966,
60,
761
]
],
[
[
623,
24,
1491
],
[
1491,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Quetiapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)"... | Quetiapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Saxagliptin (Compound)
Quetiapine (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Quetiapine may cause a moderate interaction that could exace... |
DB01045 | DB01611 | 463 | 1,487 | [
"DDInter1590",
"DDInter893"
] | Rifampicin | Hydroxychloroquine | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
463,
24,
1487
]
],
[
[
463,
63,
663
],
[
663,
23,
1487
]
],
[
[
463,
63,
723
],
[
723,
24,
1487
]
],
[
[
463,
64,
168
],
[
168,
... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant ... |
DB00572 | DB00836 | 85 | 543 | [
"DDInter136",
"DDInter1088"
] | Atropine | Loperamide | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
85,
24,
543
]
],
[
[
85,
24,
704
],
[
704,
40,
543
]
],
[
[
85,
24,
675
],
[
675,
24,
543
]
],
[
[
85,
63,
194
],
[
194,
24,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
"F... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Loperamide (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction th... |
DB08870 | DB08904 | 850 | 375 | [
"DDInter228",
"DDInter342"
] | Brentuximab vedotin | Certolizumab pegol | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
850,
25,
375
]
],
[
[
850,
63,
231
],
[
231,
24,
375
]
],
[
[
850,
24,
200
],
[
200,
63,
375
]
],
[
[
850,
64,
1066
],
[
1066,
2... | [
[
[
"Brentuximab vedotin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stavudine"
]... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00563 | DB01097 | 663 | 1,377 | [
"DDInter1174",
"DDInter1033"
] | Methotrexate | Leflunomide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
663,
25,
1377
]
],
[
[
663,
5,
11573
],
[
11573,
44,
1377
]
],
[
[
663,
6,
17404
],
[
17404,
45,
1377
]
],
[
[
663,
21,
29062
],
[
290... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Methotrexate",
"{u} (Compound) treats {v} (Disease)",
"systemic scleroderma"
],
[
"systemic scleroderma",
"{u} (Disease) is ... | Methotrexate (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Leflunomide (Compound)
Methotrexate (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Leflunomide (Compound)
Methotrexate (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is c... |
DB00877 | DB14115 | 629 | 1,312 | [
"DDInter1678",
"DDInter868"
] | Sirolimus | Human botulinum neurotoxin A/B immune globulin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Infant botulism is a rare infectious disease occurring in infants in which _Clostridium botulinum_ colonize the large intestine and being to produce botulinum neurotoxin directly in the gut. As these neurotoxins interfere with cholinergic nervous transmission, patients initially present with evident of loss of muscle t... | Major | 2 | [
[
[
629,
25,
1312
]
],
[
[
629,
24,
123
],
[
123,
24,
1312
]
],
[
[
629,
64,
1132
],
[
1132,
25,
1312
]
],
[
[
629,
25,
416
],
[
416,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Human botulinum neurotoxin A/B immune globulin"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatid... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Human botulinum neurotoxin A/B immune globulin
Sirolimus may lead to a major life threatening interaction when taken with Gent... |
DB00060 | DB00564 | 912 | 1,236 | [
"DDInter947",
"DDInter293"
] | Interferon beta-1a | Carbamazepine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
912,
24,
1236
]
],
[
[
912,
24,
362
],
[
362,
1,
1236
]
],
[
[
912,
24,
1632
],
[
1632,
62,
1236
]
],
[
[
912,
24,
1101
],
[
1101,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoi... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Nicotinamide and Nicotinamide may cause a minor inte... |
DB00026 | DB13007 | 1,184 | 1,060 | [
"DDInter94",
"DDInter642"
] | Anakinra | Enfortumab vedotin | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1184,
24,
1060
]
],
[
[
1184,
24,
270
],
[
270,
24,
1060
]
],
[
[
1184,
25,
980
],
[
980,
24,
1060
]
],
[
[
1184,
25,
1011
],
[
1011,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Anakinra may lead to a major life threatening interaction when taken with Tocilizumab and Tocilizumab ma... |
DB00682 | DB10672 | 126 | 297 | [
"DDInter1951",
"DDInter417"
] | Warfarin | Clove | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
126,
23,
297
]
],
[
[
126,
25,
235
],
[
235,
62,
297
]
],
[
[
126,
24,
578
],
[
578,
23,
297
]
],
[
[
126,
25,
1564
],
[
1564,
2... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
"{u}... | Warfarin may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor inter... |
DB09046 | DB11986 | 1,094 | 484 | [
"DDInter1201",
"DDInter648"
] | Metreleptin | Entrectinib | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1094,
24,
484
]
],
[
[
1094,
24,
466
],
[
466,
62,
484
]
],
[
[
1094,
24,
1135
],
[
1135,
23,
484
]
],
[
[
1094,
63,
1197
],
[
1197,
... | [
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Na... |
DB00346 | DB00816 | 472 | 1,674 | [
"DDInter44",
"DDInter1346"
] | Alfuzosin | Orciprenaline | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
472,
24,
1674
]
],
[
[
472,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
472,
63,
618
],
[
618,
24,
1674
]
],
[
[
472,
24,
484
],
[
484,
... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Alfuzosin",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is cau... | Alfuzosin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Orciprenal... |
DB00026 | DB01041 | 1,184 | 770 | [
"DDInter94",
"DDInter1789"
] | Anakinra | Thalidomide | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1184,
24,
770
]
],
[
[
1184,
24,
1668
],
[
1668,
1,
770
]
],
[
[
1184,
24,
4
],
[
4,
63,
770
]
],
[
[
1184,
24,
1401
],
[
1401,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a ... |
DB00877 | DB01276 | 629 | 123 | [
"DDInter1678",
"DDInter706"
] | Sirolimus | Exenatide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
629,
24,
123
]
],
[
[
629,
63,
1463
],
[
1463,
23,
123
]
],
[
[
629,
63,
1336
],
[
1336,
24,
123
]
],
[
[
629,
24,
984
],
[
984,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a minor interaction that can limit clinical effects when taken with Exenatide
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Etonogestrel and Etonogest... |
DB01138 | DB08899 | 804 | 129 | [
"DDInter1726",
"DDInter649"
] | Sulfinpyrazone | Enzalutamide | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
804,
24,
129
]
],
[
[
804,
6,
8374
],
[
8374,
45,
129
]
],
[
[
804,
62,
608
],
[
608,
23,
129
]
],
[
[
804,
63,
79
],
[
79,
24,
... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Sulfinpyrazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Sulfinpyrazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Sulfinpyrazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Enzalutamide
Sulfinpyrazo... |
DB00390 | DB12130 | 1,252 | 1,017 | [
"DDInter554",
"DDInter1094"
] | Digoxin | Lorlatinib | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1252,
24,
1017
]
],
[
[
1252,
24,
175
],
[
175,
24,
1017
]
],
[
[
1252,
24,
971
],
[
971,
63,
1017
]
],
[
[
1252,
25,
392
],
[
392,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilt... |
DB00323 | DB00748 | 1,062 | 662 | [
"DDInter1829",
"DDInter297"
] | Tolcapone | Carbinoxamine | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
1062,
24,
662
]
],
[
[
1062,
24,
1594
],
[
1594,
24,
662
]
],
[
[
1062,
6,
6017
],
[
6017,
45,
662
]
],
[
[
1062,
21,
28921
],
[
28921... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Tolcapone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carbinoxamine (Compound)
Tolcapone (Com... |
DB00682 | DB00963 | 126 | 1,263 | [
"DDInter1951",
"DDInter241"
] | Warfarin | Bromfenac | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Major | 2 | [
[
[
126,
25,
1263
]
],
[
[
126,
36,
935
],
[
935,
40,
1263
]
],
[
[
126,
64,
831
],
[
831,
40,
1263
]
],
[
[
126,
64,
1512
],
[
1512,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromfenac"
]
],
[
[
"Warfarin",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
],... | Warfarin (Compound) resembles Ketoprofen (Compound) and Warfarin may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Warfarin may lead to a major life threatening interaction when taken with Indomethacin and Indomethacin (Compound) resembl... |
DB00382 | DB01050 | 62 | 848 | [
"DDInter1734",
"DDInter900"
] | Tacrine | Ibuprofen | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Minor | 0 | [
[
[
62,
23,
848
]
],
[
[
62,
24,
752
],
[
752,
23,
848
]
],
[
[
62,
24,
1619
],
[
1619,
63,
848
]
],
[
[
62,
63,
482
],
[
482,
24,
... | [
[
[
"Tacrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ibuprofen"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[
"Cime... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may ca... |
DB00461 | DB08875 | 598 | 1,618 | [
"DDInter1254",
"DDInter262"
] | Nabumetone | Cabozantinib | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
598,
25,
1618
]
],
[
[
598,
24,
384
],
[
384,
63,
1618
]
],
[
[
598,
24,
850
],
[
850,
24,
1618
]
],
[
[
598,
25,
629
],
[
629,
... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
"Idelalis... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin... |
DB00284 | DB01105 | 1,647 | 222 | [
"DDInter11",
"DDInter1665"
] | Acarbose | Sibutramine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1647,
24,
222
]
],
[
[
1647,
21,
28880
],
[
28880,
60,
222
]
],
[
[
1647,
24,
839
],
[
839,
23,
222
]
],
[
[
1647,
24,
384
],
[
384,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Acarbose",
"{u} (Compound) causes {v} (Side Effect)",
"Angiopathy"
],
[
"Angiopathy",
"{u} (Side Effect) is cause... | Acarbose (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Sibutramine (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibu... |
DB01110 | DB01238 | 86 | 673 | [
"DDInter1209",
"DDInter118"
] | Miconazole | Aripiprazole | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
86,
24,
673
]
],
[
[
86,
24,
851
],
[
851,
1,
673
]
],
[
[
86,
63,
827
],
[
827,
40,
673
]
],
[
[
86,
6,
3958
],
[
3958,
45,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound... |
DB00191 | DB00193 | 73 | 534 | [
"DDInter1447",
"DDInter1841"
] | Phentermine | Tramadol | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Major | 2 | [
[
[
73,
25,
534
]
],
[
[
73,
25,
1100
],
[
1100,
40,
534
]
],
[
[
73,
24,
506
],
[
506,
1,
534
]
],
[
[
73,
6,
6112
],
[
6112,
45,
... | [
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
]
],
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venlafaxine"
],
[
"Venlafaxine",
"{u}... | Phentermine may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine (Compound) resembles Tramadol (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan (Compound) resembles Tramadol (Compound)
Phe... |
DB00197 | DB09381 | 1,324 | 192 | [
"DDInter1881",
"DDInter678"
] | Troglitazone | Esterified estrogens | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1324,
24,
192
]
],
[
[
1324,
24,
1019
],
[
1019,
63,
192
]
],
[
[
1324,
24,
723
],
[
723,
24,
192
]
],
[
[
1324,
63,
176
],
[
176,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprep... |
DB00529 | DB01211 | 789 | 609 | [
"DDInter779",
"DDInter393"
] | Foscarnet | Clarithromycin | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
789,
24,
609
]
],
[
[
789,
21,
28662
],
[
28662,
60,
609
]
],
[
[
789,
63,
600
],
[
600,
23,
609
]
],
[
[
789,
23,
112
],
[
112,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Tremor"
],
[
"Tremor",
"{u} (Side Effect) is caused b... | Foscarnet (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Clarithromy... |
DB00279 | DB00364 | 1,152 | 417 | [
"DDInter1074",
"DDInter1717"
] | Liothyronine | Sucralfate | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protec... | Minor | 0 | [
[
[
1152,
23,
417
]
],
[
[
1152,
6,
1829
],
[
1829,
45,
417
]
],
[
[
1152,
21,
28882
],
[
28882,
60,
417
]
],
[
[
1152,
23,
17
],
[
17,
... | [
[
[
"Liothyronine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sucralfate"
]
],
[
[
"Liothyronine",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Liothyronine (Compound) binds ALB (Gene) and ALB (Gene) is bound by Sucralfate (Compound)
Liothyronine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sucralfate (Compound)
Liothyronine may cause a minor interaction that can limit clinical effects whe... |
DB00604 | DB06788 | 1,425 | 1,616 | [
"DDInter385",
"DDInter864"
] | Cisapride | Histrelin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
1425,
25,
1616
]
],
[
[
1425,
23,
112
],
[
112,
23,
1616
]
],
[
[
1425,
25,
1664
],
[
1664,
24,
1616
]
],
[
[
1425,
64,
1251
],
[
1251... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Cisapride may lead to a major life threatening interaction when taken with Risperidone and Risperidone may cause... |
DB09054 | DB15035 | 384 | 503 | [
"DDInter905",
"DDInter1959"
] | Idelalisib | Zanubrutinib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
384,
25,
503
]
],
[
[
384,
63,
1094
],
[
1094,
24,
503
]
],
[
[
384,
25,
982
],
[
982,
24,
503
]
],
[
[
384,
62,
222
],
[
222,
2... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
"Metrele... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Idelalisib may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may ca... |
DB00604 | DB04844 | 1,425 | 843 | [
"DDInter385",
"DDInter1778"
] | Cisapride | Tetrabenazine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Major | 2 | [
[
[
1425,
25,
843
]
],
[
[
1425,
24,
479
],
[
479,
40,
843
]
],
[
[
1425,
6,
12523
],
[
12523,
45,
843
]
],
[
[
1425,
23,
112
],
[
112,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
"Donepezil"... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Cisapride (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Cisapride may cause a minor interaction that can limit clinical ... |
DB01089 | DB01364 | 1,340 | 22 | [
"DDInter502",
"DDInter650"
] | Deserpidine | Ephedrine | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1340,
24,
22
]
],
[
[
1340,
63,
1445
],
[
1445,
1,
22
]
],
[
[
1340,
6,
6771
],
[
6771,
45,
22
]
],
[
[
1340,
24,
1220
],
[
1220,
... | [
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
... | Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Ephedrine (Compound)
Deserpidine (Compound) binds SLC18A2 (Gene) and SLC18A2 (Gene) is bound by Ephedrine (Compound)
Deserpidine may cause a moderate interaction that coul... |
DB00563 | DB01009 | 663 | 935 | [
"DDInter1174",
"DDInter1009"
] | Methotrexate | Ketoprofen | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Major | 2 | [
[
[
663,
25,
935
]
],
[
[
663,
24,
1523
],
[
1523,
40,
935
]
],
[
[
663,
63,
847
],
[
847,
1,
935
]
],
[
[
663,
25,
1274
],
[
1274,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
"Labetal... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Ketoprofen (Compou... |
DB00713 | DB01017 | 1,138 | 1,669 | [
"DDInter1354",
"DDInter1224"
] | Oxacillin | Minocycline | An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections. | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Moderate | 1 | [
[
[
1138,
24,
1669
]
],
[
[
1138,
63,
1572
],
[
1572,
1,
1669
]
],
[
[
1138,
63,
1545
],
[
1545,
40,
1669
]
],
[
[
1138,
24,
1620
],
[
162... | [
[
[
"Oxacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minocycline"
]
],
[
[
"Oxacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],
[... | Oxacillin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Oxacillin may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline (Compound) resembles Minoc... |
DB00106 | DB00557 | 618 | 252 | [
"DDInter4",
"DDInter895"
] | Abarelix | Hydroxyzine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Moderate | 1 | [
[
[
618,
24,
252
]
],
[
[
618,
24,
1630
],
[
1630,
1,
252
]
],
[
[
618,
24,
623
],
[
623,
40,
252
]
],
[
[
618,
23,
112
],
[
112,
62... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
[
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Hydroxyzine (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Hydroxyzine (Compound... |
DB00436 | DB09268 | 323 | 1,662 | [
"DDInter179",
"DDInter1464"
] | Bendroflumethiazide | Picosulfuric acid | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
323,
24,
1662
]
],
[
[
323,
24,
708
],
[
708,
24,
1662
]
],
[
[
323,
40,
504
],
[
504,
24,
1662
]
],
[
[
323,
62,
964
],
[
964,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Co... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Bendroflumethiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hydrochlorothi... |
DB00556 | DB08946 | 1,262 | 512 | [
"DDInter1429",
"DDInter962"
] | Perflutren | Iopanoic acid | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
1262,
24,
512
]
],
[
[
1262,
24,
888
],
[
888,
7,
7669
],
[
7669,
46,
512
]
],
[
[
1262,
63,
1010
],
[
1010,
7,
7669
],
[
7669,
46,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
... | Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Iopanoic acid (Compound)
Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mef... |
DB01087 | DB05812 | 1,520 | 1,374 | [
"DDInter1520",
"DDInter8"
] | Primaquine | Abiraterone | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1520,
24,
1374
]
],
[
[
1520,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
1520,
21,
28658
],
[
28658,
60,
1374
]
],
[
[
1520,
62,
112
],
[
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Primaquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Primaquine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Abiraterone (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
DB08895 | DB09312 | 976 | 967 | [
"DDInter1825",
"DDInter103"
] | Tofacitinib | Antilymphocyte immunoglobulin (horse) | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Major | 2 | [
[
[
976,
64,
967
]
],
[
[
976,
23,
1193
],
[
1193,
62,
967
]
],
[
[
976,
62,
1461
],
[
1461,
62,
967
]
],
[
[
976,
64,
1683
],
[
1683,
... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antilymphocyte immunoglobulin (horse)"
]
],
[
[
"Tofacitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"... | Tofacitinib may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Antilymphocyte immunoglobulin (horse)
Tofacitinib may cause a minor interaction that can limit clinical effects when t... |
DB00209 | DB00981 | 352 | 1,528 | [
"DDInter1886",
"DDInter1462"
] | Trospium | Physostigmine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
352,
24,
1528
]
],
[
[
352,
21,
28658
],
[
28658,
60,
1528
]
],
[
[
352,
24,
1592
],
[
1592,
63,
1528
]
],
[
[
352,
24,
508
],
[
508,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Trospium",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused ... | Trospium (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Physostigmine (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol and Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Physostigmin... |
DB01169 | DB09083 | 57 | 880 | [
"DDInter120",
"DDInter996"
] | Arsenic trioxide | Ivabradine | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
57,
25,
880
]
],
[
[
57,
63,
480
],
[
480,
24,
880
]
],
[
[
57,
64,
1148
],
[
1148,
24,
880
]
],
[
[
57,
24,
659
],
[
659,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Arsenic trioxide may lead to a major life threatening interaction when taken with Isoprenaline and Isopren... |
DB08865 | DB09268 | 1,593 | 1,662 | [
"DDInter448",
"DDInter1464"
] | Crizotinib | Picosulfuric acid | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1593,
24,
1662
]
],
[
[
1593,
63,
1482
],
[
1482,
23,
1662
]
],
[
[
1593,
64,
1164
],
[
1164,
24,
1662
]
],
[
[
1593,
25,
484
],
[
484... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Crizotinib may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may... |
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