drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01072 | DB01098 | 915 | 14 | [
"DDInter129",
"DDInter1622"
] | Atazanavir | Rosuvastatin | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Major | 2 | [
[
[
915,
25,
14
]
],
[
[
915,
6,
10417
],
[
10417,
45,
14
]
],
[
[
915,
21,
29579
],
[
29579,
60,
14
]
],
[
[
915,
63,
303
],
[
303,
... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Atazanavir",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound)",
"Rosuvas... | Atazanavir (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Rosuvastatin (Compound)
Atazanavir (Compound) causes Breast disorder (Side Effect) and Breast disorder (Side Effect) is caused by Rosuvastatin (Compound)
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Medro... |
DB00619 | DB15965 | 1,419 | 1,330 | [
"DDInter909",
"DDInter1270"
] | Imatinib | Naxitamab | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
1419,
24,
1330
]
],
[
[
1419,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
1419,
63,
10
],
[
10,
24,
1330
]
],
[
[
1419,
25,
1362
],
[
1362,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may ca... |
DB00214 | DB01278 | 1,028 | 1,021 | [
"DDInter1836",
"DDInter1506"
] | Torasemide | Pramlintide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1028,
24,
1021
]
],
[
[
1028,
24,
708
],
[
708,
63,
1021
]
],
[
[
1028,
24,
891
],
[
891,
24,
1021
]
],
[
[
1028,
63,
1685
],
[
1685,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone a... |
DB00696 | DB12130 | 826 | 1,017 | [
"DDInter665",
"DDInter1094"
] | Ergotamine | Lorlatinib | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
826,
24,
1017
]
],
[
[
826,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
826,
24,
1446
],
[
1446,
24,
1017
]
],
[
[
826,
40,
588
],
[
588,
... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide and Lanreoti... |
DB00569 | DB09075 | 553 | 498 | [
"DDInter775",
"DDInter621"
] | Fondaparinux | Edoxaban | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
553,
25,
498
]
],
[
[
553,
23,
944
],
[
944,
62,
498
]
],
[
[
553,
24,
1004
],
[
1004,
63,
498
]
],
[
[
553,
24,
41
],
[
41,
24,... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",... | Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phe... |
DB00413 | DB01075 | 1,346 | 1,376 | [
"DDInter1505",
"DDInter569"
] | Pramipexole | Diphenhydramine | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the mos... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1346,
24,
1376
]
],
[
[
1346,
24,
649
],
[
649,
63,
1376
]
],
[
[
1346,
63,
128
],
[
128,
24,
1376
]
],
[
[
1346,
24,
832
],
[
832,
... | [
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphenira... |
DB00662 | DB00679 | 717 | 684 | [
"DDInter1873",
"DDInter1796"
] | Trimethobenzamide | Thioridazine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
717,
24,
684
]
],
[
[
717,
24,
1237
],
[
1237,
40,
684
]
],
[
[
717,
63,
216
],
[
216,
1,
684
]
],
[
[
717,
24,
1630
],
[
1630,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramin... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) rese... |
DB01235 | DB06186 | 1,191 | 1,439 | [
"DDInter1054",
"DDInter969"
] | Levodopa | Ipilimumab | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
1191,
24,
1439
]
],
[
[
1191,
63,
268
],
[
268,
24,
1439
]
],
[
[
1191,
24,
310
],
[
310,
63,
1439
]
],
[
[
1191,
24,
309
],
[
309,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Cab... |
DB00163 | DB00975 | 1,461 | 1,317 | [
"DDInter1943",
"DDInter573"
] | Vitamin E | Dipyridamole | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
1461,
24,
1317
]
],
[
[
1461,
7,
2384
],
[
2384,
46,
1317
]
],
[
[
1461,
24,
714
],
[
714,
63,
1317
]
],
[
[
1461,
63,
942
],
[
942,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Vitamin E",
"{u} (Compound) upregulates {v} (Gene)",
"CDK6"
],
[
"CDK6",
"{u} (Gene) is upregulated by {v} (Com... | Vitamin E (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Dipyridamole (Compound)
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Vitamin E ma... |
DB00106 | DB00656 | 618 | 827 | [
"DDInter4",
"DDInter1851"
] | Abarelix | Trazodone | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Moderate | 1 | [
[
[
618,
24,
827
]
],
[
[
618,
24,
623
],
[
623,
40,
827
]
],
[
[
618,
24,
1630
],
[
1630,
1,
827
]
],
[
[
618,
25,
695
],
[
695,
1,... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
"... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compound)
Ab... |
DB00446 | DB00833 | 597 | 1,305 | [
"DDInter351",
"DDInter309"
] | Chloramphenicol | Cefaclor | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Semisynthetic, broad-spectrum antibiotic derivative of cephalexin. | Moderate | 1 | [
[
[
597,
24,
1305
]
],
[
[
597,
24,
1124
],
[
1124,
40,
1305
]
],
[
[
597,
24,
1145
],
[
1145,
1,
1305
]
],
[
[
597,
63,
790
],
[
790,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefaclor"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefamandole"
],... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefamandole and Cefamandole (Compound) resembles Cefaclor (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefdinir and Cefdinir (Compound) resembles Cefaclor (Compou... |
DB06608 | DB06637 | 1,185 | 1,109 | [
"DDInter1739",
"DDInter468"
] | Tafenoquine | Dalfampridine | Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria. Tafenoq... | Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010. | Moderate | 1 | [
[
[
1185,
24,
1109
]
],
[
[
1185,
63,
1645
],
[
1645,
24,
1109
]
],
[
[
1185,
63,
10
],
[
10,
6,
6365
],
[
6365,
45,
1109
]
],
[
[
1185,
... | [
[
[
"Tafenoquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfampridine"
]
],
[
[
"Tafenoquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
... | Tafenoquine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Dalfampridine
Tafenoquine may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapson... |
DB08882 | DB12887 | 1,281 | 1,598 | [
"DDInter1070",
"DDInter1750"
] | Linagliptin | Tazemetostat | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
1281,
24,
1598
]
],
[
[
1281,
63,
168
],
[
168,
23,
1598
]
],
[
[
1281,
63,
1039
],
[
1039,
24,
1598
]
],
[
[
1281,
24,
1476
],
[
1476... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and... |
DB09122 | DB14761 | 1,613 | 242 | [
"DDInter1409",
"DDInter1578"
] | Peginterferon beta-1a | Remdesivir | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1613,
24,
242
]
],
[
[
1613,
63,
1130
],
[
1130,
24,
242
]
],
[
[
1613,
64,
1377
],
[
1377,
24,
242
]
],
[
[
1613,
24,
971
],
[
971,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piogl... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Peginterferon beta-1a may lead to a major life threatening interaction when taken with Leflunomid... |
DB06616 | DB08826 | 594 | 1,292 | [
"DDInter224",
"DDInter489"
] | Bosutinib | Deferiprone | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
594,
25,
1292
]
],
[
[
594,
6,
2240
],
[
2240,
46,
1292
]
],
[
[
594,
21,
28759
],
[
28759,
60,
1292
]
],
[
[
594,
25,
1017
],
[
1017,... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Bosutinib",
"{u} (Compound) binds {v} (Gene)",
"BTK"
],
[
"BTK",
"{u} (Gene) is upregulated by {v} (Compound)",
"Deferipr... | Bosutinib (Compound) binds BTK (Gene) and BTK (Gene) is upregulated by Deferiprone (Compound)
Bosutinib (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Deferiprone (Compound)
Bosutinib may lead to a major life threatening interaction when taken with L... |
DB01149 | DB05381 | 851 | 172 | [
"DDInter1274",
"DDInter863"
] | Nefazodone | Histamine | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
851,
24,
172
]
],
[
[
851,
64,
1264
],
[
1264,
24,
172
]
],
[
[
851,
63,
1601
],
[
1601,
24,
172
]
],
[
[
851,
24,
849
],
[
849,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
],
[
"Doxepin",
... | Nefazodone may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine may cause a moder... |
DB00005 | DB00970 | 1,057 | 0 | [
"DDInter687",
"DDInter466"
] | Etanercept | Dactinomycin | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Major | 2 | [
[
[
1057,
25,
0
]
],
[
[
1057,
25,
259
],
[
259,
63,
0
]
],
[
[
1057,
24,
496
],
[
496,
63,
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]
],
[
[
1057,
25,
1184
],
[
1184,
24,... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dactinomycin"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacept",
"{u}... | Etanercept may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis ... |
DB00850 | DB12500 | 1,630 | 283 | [
"DDInter1432",
"DDInter714"
] | Perphenazine | Fedratinib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1630,
24,
283
]
],
[
[
1630,
25,
351
],
[
351,
23,
283
]
],
[
[
1630,
63,
1419
],
[
1419,
24,
283
]
],
[
[
1630,
24,
761
],
[
761,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Riboci... | Perphenazine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a ... |
DB00197 | DB01059 | 1,324 | 956 | [
"DDInter1881",
"DDInter1313"
] | Troglitazone | Norfloxacin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
1324,
24,
956
]
],
[
[
1324,
24,
872
],
[
872,
40,
956
]
],
[
[
1324,
24,
1176
],
[
1176,
1,
956
]
],
[
[
1324,
25,
246
],
[
246,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxac... |
DB00381 | DB00586 | 376 | 1,512 | [
"DDInter79",
"DDInter537"
] | Amlodipine | Diclofenac | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
376,
24,
1512
]
],
[
[
376,
6,
8374
],
[
8374,
45,
1512
]
],
[
[
376,
18,
2801
],
[
2801,
57,
1512
]
],
[
[
376,
21,
29231
],
[
29231,... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Amlodipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diclofenac (Compound)
Amlodipine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Diclofenac (Compound)
Amlodipine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Diclofenac... |
DB01128 | DB04868 | 918 | 478 | [
"DDInter204",
"DDInter1293"
] | Bicalutamide | Nilotinib | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
918,
25,
478
]
],
[
[
918,
6,
6017
],
[
6017,
45,
478
]
],
[
[
918,
7,
17537
],
[
17537,
46,
478
]
],
[
[
918,
21,
28963
],
[
28963,
... | [
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Bicalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Nilo... | Bicalutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Bicalutamide (Compound) upregulates USP6NL (Gene) and USP6NL (Gene) is upregulated by Nilotinib (Compound)
Bicalutamide (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Bical... |
DB00477 | DB00731 | 216 | 1,144 | [
"DDInter363",
"DDInter1269"
] | Chlorpromazine | Nateglinide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
216,
24,
1144
]
],
[
[
216,
6,
1829
],
[
1829,
45,
1144
]
],
[
[
216,
7,
4789
],
[
4789,
45,
1144
]
],
[
[
216,
21,
29222
],
[
29222,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound... | Chlorpromazine (Compound) binds ALB (Gene) and ALB (Gene) is bound by Nateglinide (Compound)
Chlorpromazine (Compound) upregulates PPARG (Gene) and PPARG (Gene) is bound by Nateglinide (Compound)
Chlorpromazine (Compound) causes Hypoglycaemia (Side Effect) and Hypoglycaemia (Side Effect) is caused by Nateglinide (Compo... |
DB03904 | DB06292 | 1,574 | 549 | [
"DDInter1903",
"DDInter474"
] | Urea | Dapagliflozin | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1574,
24,
549
]
],
[
[
1574,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1574,
63,
222
],
[
222,
24,
549
]
],
[
[
1574,
24,
1455
],
[
1455,
... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
"C... | Urea may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Urea may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could ... |
DB00342 | DB00845 | 1,181 | 1,490 | [
"DDInter1770",
"DDInter406"
] | Terfenadine | Clofazimine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Moderate | 1 | [
[
[
1181,
24,
1490
]
],
[
[
1181,
23,
112
],
[
112,
62,
1490
]
],
[
[
1181,
24,
1250
],
[
1250,
63,
1490
]
],
[
[
1181,
24,
51
],
[
51,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofazimine"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Clofazimine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pa... |
DB00934 | DB06603 | 413 | 39 | [
"DDInter1124",
"DDInter1387"
] | Maprotiline | Panobinostat | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
413,
25,
39
]
],
[
[
413,
62,
112
],
[
112,
23,
39
]
],
[
[
413,
24,
272
],
[
272,
24,
39
]
],
[
[
413,
63,
1559
],
[
1559,
24,
... | [
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Maprotiline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramin... |
DB06822 | DB14357 | 802 | 944 | [
"DDInter1812",
"DDInter347"
] | Tinzaparin | Chamomile | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
802,
23,
944
]
],
[
[
802,
64,
256
],
[
256,
23,
944
]
],
[
[
802,
25,
498
],
[
498,
23,
944
]
],
[
[
802,
64,
256
],
[
256,
64,... | [
[
[
"Tinzaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Tinzaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Tinzaparin may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Tinzaparin may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a minor interaction that... |
DB00582 | DB09472 | 1,622 | 1,383 | [
"DDInter1946",
"DDInter1693"
] | Voriconazole | Sodium sulfate | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1622,
24,
1383
]
],
[
[
1622,
24,
609
],
[
609,
24,
1383
]
],
[
[
1622,
63,
521
],
[
521,
24,
1383
]
],
[
[
1622,
74,
600
],
[
600,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Goser... |
DB00047 | DB00668 | 176 | 874 | [
"DDInter932",
"DDInter652"
] | Insulin glargine | Epinephrine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
176,
24,
874
]
],
[
[
176,
24,
1636
],
[
1636,
1,
874
]
],
[
[
176,
24,
688
],
[
688,
63,
874
]
],
[
[
176,
24,
1399
],
[
1399,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate int... |
DB00381 | DB12010 | 376 | 214 | [
"DDInter79",
"DDInter785"
] | Amlodipine | Fostamatinib | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
376,
24,
214
]
],
[
[
376,
40,
1428
],
[
1428,
24,
214
]
],
[
[
376,
24,
723
],
[
723,
24,
214
]
],
[
[
376,
63,
600
],
[
600,
2... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Amlodipine",
"{u} (Compound) resembles {v} (Compound)",
"Isradipine"
],
[
"Isradipine",
"{u} may cause a moder... | Amlodipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that cou... |
DB01320 | DB12015 | 651 | 1,033 | [
"DDInter783",
"DDInter53"
] | Fosphenytoin | Alpelisib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Major | 2 | [
[
[
651,
25,
1033
]
],
[
[
651,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
651,
63,
1254
],
[
1254,
24,
1033
]
],
[
[
651,
24,
738
],
[
738,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alpelisib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ... | Fosphenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisi... |
DB06791 | DB09564 | 1,446 | 1,296 | [
"DDInter1021",
"DDInter930"
] | Lanreotide | Insulin degludec | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1446,
24,
1296
]
],
[
[
1446,
63,
17
],
[
17,
24,
1296
]
],
[
[
1446,
24,
52
],
[
52,
24,
1296
]
],
[
[
1446,
24,
1385
],
[
1385,
... | [
[
[
"Lanreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Lanreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
],
[... | Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulag... |
DB00759 | DB00982 | 1,620 | 1,517 | [
"DDInter1783",
"DDInter991"
] | Tetracycline | Isotretinoin | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Major | 2 | [
[
[
1620,
25,
1517
]
],
[
[
1620,
64,
640
],
[
640,
25,
1517
]
],
[
[
1620,
24,
637
],
[
637,
63,
1517
]
],
[
[
1620,
63,
663
],
[
663,
... | [
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isotretinoin"
]
],
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acitretin"
],
[
"Acitretin",
"{... | Tetracycline may lead to a major life threatening interaction when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi and Asparagin... |
DB00554 | DB01240 | 1,027 | 885 | [
"DDInter1478",
"DDInter657"
] | Piroxicam | Epoprostenol | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1027,
24,
885
]
],
[
[
1027,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1027,
6,
6017
],
[
6017,
45,
885
]
],
[
[
1027,
24,
1512
],
[
1512,
... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Piroxicam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Piroxicam may cause a moderate interaction that could exacer... |
DB06718 | DB14761 | 1,687 | 242 | [
"DDInter1709",
"DDInter1578"
] | Stanozolol | Remdesivir | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1687,
24,
242
]
],
[
[
1687,
64,
1377
],
[
1377,
24,
242
]
],
[
[
1687,
24,
384
],
[
384,
24,
242
]
],
[
[
1687,
63,
482
],
[
482,
... | [
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Stanozolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Leflunomi... | Stanozolol may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may caus... |
DB00086 | DB14006 | 1,167 | 972 | [
"DDInter1712",
"DDInter370"
] | Streptokinase | Choline salicylate | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1167,
24,
972
]
],
[
[
1167,
25,
553
],
[
553,
24,
972
]
],
[
[
1167,
24,
885
],
[
885,
24,
972
]
],
[
[
1167,
64,
1578
],
[
1578,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
... | Streptokinase may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and E... |
DB00662 | DB00719 | 717 | 1,219 | [
"DDInter1873",
"DDInter149"
] | Trimethobenzamide | Azatadine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
717,
24,
1219
]
],
[
[
717,
63,
13
],
[
13,
24,
1219
]
],
[
[
717,
24,
1405
],
[
1405,
63,
1219
]
],
[
[
717,
24,
1216
],
[
1216,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00603 | DB12095 | 303 | 179 | [
"DDInter1137",
"DDInter1760"
] | Medroxyprogesterone acetate | Telotristat ethyl | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
303,
24,
179
]
],
[
[
303,
24,
1517
],
[
1517,
24,
179
]
],
[
[
303,
24,
283
],
[
283,
63,
179
]
],
[
[
303,
63,
1324
],
[
1324,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate d... |
DB01229 | DB14444 | 973 | 151 | [
"DDInter1377",
"DDInter924"
] | Paclitaxel | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
973,
24,
151
]
],
[
[
973,
63,
66
],
[
66,
24,
151
]
],
[
[
973,
24,
1619
],
[
1619,
24,
151
]
],
[
[
973,
25,
375
],
[
375,
24,... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could e... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Paclitaxel may cause a moderate inter... |
DB09079 | DB12141 | 1,496 | 971 | [
"DDInter1296",
"DDInter817"
] | Nintedanib | Gilteritinib | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1496,
24,
971
]
],
[
[
1496,
24,
1097
],
[
1097,
24,
971
]
],
[
[
1496,
63,
1627
],
[
1627,
24,
971
]
],
[
[
1496,
24,
242
],
[
242,
... | [
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
],
[
... | Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan and Lasmiditan may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib
Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Can... |
DB00279 | DB04574 | 1,152 | 177 | [
"DDInter1074",
"DDInter684"
] | Liothyronine | Estrone sulfate (topical) | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Estrone 3-sulfate is a steroid sulfate that is the 3-sulfate of estrone. It has a role as a human metabolite and a mouse metabolite. It is a 17-oxo steroid and a steroid sulfate. It is functionally related to an estrone. It is a conjugate acid of an estrone 3-sulfate(1-). It derives from a hydride of an estrane. | Moderate | 1 | [
[
[
1152,
24,
177
]
],
[
[
1152,
24,
380
],
[
380,
1,
177
]
],
[
[
1152,
6,
1829
],
[
1829,
45,
177
]
],
[
[
1152,
21,
28890
],
[
28890,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone sulfate"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conjugated estroge... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Estrone sulfate
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Estrone sulfate (Compound)
Liothyronine (Compound) ... |
DB00635 | DB14730 | 1,573 | 1,412 | [
"DDInter1515",
"DDInter264"
] | Prednisone | Calaspargase pegol | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1573,
24,
1412
]
],
[
[
1573,
24,
1439
],
[
1439,
24,
1412
]
],
[
[
1573,
63,
1647
],
[
1647,
24,
1412
]
],
[
[
1573,
40,
251
],
[
251... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
],
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and ... |
DB01100 | DB13074 | 1,568 | 877 | [
"DDInter1470",
"DDInter1110"
] | Pimozide | Macimorelin | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1568,
25,
877
]
],
[
[
1568,
62,
112
],
[
112,
23,
877
]
],
[
[
1568,
63,
85
],
[
85,
24,
877
]
],
[
[
1568,
25,
913
],
[
913,
2... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Pimozide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine ... |
DB00586 | DB01191 | 1,512 | 1,039 | [
"DDInter537",
"DDInter518"
] | Diclofenac | Dexfenfluramine | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1512,
24,
1039
]
],
[
[
1512,
6,
10215
],
[
10215,
45,
1039
]
],
[
[
1512,
23,
479
],
[
479,
23,
1039
]
],
[
[
1512,
24,
1046
],
[
104... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Comp... | Diclofenac (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexfenfluramine (Compound)
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Dexfenfluramine
Diclofenac m... |
DB00046 | DB01294 | 1,179 | 266 | [
"DDInter940",
"DDInter215"
] | Insulin lispro | Bismuth subsalicylate | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of [salicylic acid] linked to trivalent [bismuth cation]. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth s... | Moderate | 1 | [
[
[
1179,
24,
266
]
],
[
[
1179,
24,
1620
],
[
1620,
24,
266
]
],
[
[
1179,
24,
1620
],
[
1620,
6,
1829
],
[
1829,
45,
266
]
],
[
[
1179,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bismuth subsalicylate"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracyc... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Bismuth subsalicylate
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01309 | DB09100 | 1,254 | 320 | [
"DDInter933",
"DDInter1799"
] | Insulin glulisine | Thyroid, porcine | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1254,
24,
320
]
],
[
[
1254,
63,
417
],
[
417,
23,
320
]
],
[
[
1254,
63,
127
],
[
127,
24,
320
]
],
[
[
1254,
24,
135
],
[
135,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralf... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Mig... |
DB00370 | DB01142 | 1,251 | 1,264 | [
"DDInter1230",
"DDInter593"
] | Mirtazapine | Doxepin | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
1251,
25,
1264
]
],
[
[
1251,
24,
401
],
[
401,
24,
1264
]
],
[
[
1251,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
1251,
24,
649
],
[
649,
... | [
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Promethaz... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Dox... |
DB00041 | DB00780 | 1,648 | 551 | [
"DDInter38",
"DDInter1440"
] | Aldesleukin | Phenelzine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Moderate | 1 | [
[
[
1648,
24,
551
]
],
[
[
1648,
24,
1161
],
[
1161,
40,
551
]
],
[
[
1648,
24,
999
],
[
999,
24,
551
]
],
[
[
1648,
24,
537
],
[
537,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline (Compound) resembles Phenelzine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may cause a moderate interact... |
DB09054 | DB10316 | 384 | 334 | [
"DDInter905",
"DDInter1248"
] | Idelalisib | Mumps virus strain B level jeryl lynn live antigen | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
384,
25,
334
]
],
[
[
384,
64,
617
],
[
617,
24,
334
]
],
[
[
384,
64,
594
],
[
594,
25,
334
]
],
[
[
384,
24,
1316
],
[
1316,
6... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
]... | Idelalisib may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Mumps virus strain B level jeryl lynn live antigen
Idelalisib may lead to a major life threatening interaction when taken with Bosutinib a... |
DB00218 | DB00855 | 1,176 | 213 | [
"DDInter1247",
"DDInter72"
] | Moxifloxacin | Aminolevulinic acid | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
1176,
25,
213
]
],
[
[
1176,
21,
30100
],
[
30100,
60,
213
]
],
[
[
1176,
24,
848
],
[
848,
64,
213
]
],
[
[
1176,
1,
956
],
[
956,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Eyelid oedema"
],
[
"Eyelid oedema",
"{u} (Side Effect) i... | Moxifloxacin (Compound) causes Eyelid oedema (Side Effect) and Eyelid oedema (Side Effect) is caused by Aminolevulinic acid (Compound)
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead to a major life threatening interaction when taken with Ami... |
DB00862 | DB01169 | 1,005 | 57 | [
"DDInter1918",
"DDInter120"
] | Vardenafil | Arsenic trioxide | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1005,
25,
57
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1005,
24,
112
],
[
112,
23,
57
]
],
[
[
1005,
24,
603
],
[
603,
6... | [
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"A... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Va... |
DB00673 | DB08873 | 723 | 74 | [
"DDInter112",
"DDInter221"
] | Aprepitant | Boceprevir | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
723,
24,
74
]
],
[
[
723,
6,
8374
],
[
8374,
45,
74
]
],
[
[
723,
54,
19146
],
[
19146,
15,
74
]
],
[
[
723,
21,
28769
],
[
28769,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Aprepitant (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Boceprevir (Compound)
Aprepitant (Compound) causes Feeling abnormal (S... |
DB01211 | DB11837 | 609 | 1,297 | [
"DDInter393",
"DDInter1351"
] | Clarithromycin | Osilodrostat | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
609,
25,
1297
]
],
[
[
609,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
609,
62,
112
],
[
112,
23,
1297
]
],
[
[
609,
24,
466
],
[
466,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Clarithromycin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole ... |
DB00295 | DB00952 | 475 | 1,541 | [
"DDInter1244",
"DDInter1267"
] | Morphine | Naratriptan | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches. | Moderate | 1 | [
[
[
475,
24,
1541
]
],
[
[
475,
24,
399
],
[
399,
1,
1541
]
],
[
[
475,
21,
29324
],
[
29324,
60,
1541
]
],
[
[
475,
24,
1166
],
[
1166,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naratriptan"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sumatriptan"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Sumatriptan and Sumatriptan (Compound) resembles Naratriptan (Compound)
Morphine (Compound) causes Neuralgia (Side Effect) and Neuralgia (Side Effect) is caused by Naratriptan (Compound)
Morphine may cause a moderate interaction th... |
DB01064 | DB12245 | 1,148 | 823 | [
"DDInter987",
"DDInter1863"
] | Isoprenaline | Triclabendazole | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1148,
24,
823
]
],
[
[
1148,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1148,
63,
1010
],
[
1010,
24,
823
]
],
[
[
1148,
24,
1619
],
[
1619,... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine... |
DB00656 | DB01105 | 827 | 222 | [
"DDInter1851",
"DDInter1665"
] | Trazodone | Sibutramine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
827,
25,
222
]
],
[
[
827,
6,
8374
],
[
8374,
45,
222
]
],
[
[
827,
21,
29356
],
[
29356,
60,
222
]
],
[
[
827,
24,
384
],
[
384,
... | [
[
[
"Trazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Sibutram... | Trazodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Trazodone (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when tak... |
DB01229 | DB06636 | 973 | 1,623 | [
"DDInter1378",
"DDInter980"
] | Paclitaxel (protein-bound) | Isavuconazonium | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
973,
24,
1623
]
],
[
[
973,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
973,
24,
309
],
[
309,
24,
1623
]
],
[
[
973,
24,
1593
],
[
1593,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Pacl... |
DB00252 | DB00959 | 362 | 1,486 | [
"DDInter1460",
"DDInter1191"
] | Phenytoin | Methylprednisolone | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
362,
24,
1486
]
],
[
[
362,
24,
175
],
[
175,
40,
1486
]
],
[
[
362,
24,
167
],
[
167,
1,
1486
]
],
[
[
362,
6,
8374
],
[
8374,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Me... |
DB00092 | DB00762 | 58 | 613 | [
"DDInter40",
"DDInter973"
] | Alefacept | Irinotecan | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
58,
24,
613
]
],
[
[
58,
24,
869
],
[
869,
63,
613
]
],
[
[
58,
63,
599
],
[
599,
24,
613
]
],
[
[
58,
24,
1555
],
[
1555,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzum... |
DB01064 | DB04946 | 1,148 | 924 | [
"DDInter987",
"DDInter907"
] | Isoprenaline | Iloperidone | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
1148,
25,
924
]
],
[
[
1148,
63,
1664
],
[
1664,
1,
924
]
],
[
[
1148,
64,
1425
],
[
1425,
25,
924
]
],
[
[
1148,
24,
519
],
[
519,
... | [
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
"Risp... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Isoprenaline may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when... |
DB00365 | DB05294 | 839 | 1,069 | [
"DDInter842",
"DDInter1917"
] | Grepafloxacin | Vandetanib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
839,
25,
1069
]
],
[
[
839,
24,
1195
],
[
1195,
40,
1069
]
],
[
[
839,
24,
1215
],
[
1215,
23,
1069
]
],
[
[
839,
23,
112
],
[
112,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
"Erlot... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that ... |
DB00414 | DB00774 | 590 | 1,577 | [
"DDInter16",
"DDInter889"
] | Acetohexamide | Hydroflumethiazide | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Moderate | 1 | [
[
[
590,
24,
1577
]
],
[
[
590,
24,
359
],
[
359,
40,
1577
]
],
[
[
590,
24,
504
],
[
504,
1,
1577
]
],
[
[
590,
24,
761
],
[
761,
6... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazid... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Co... |
DB06636 | DB11581 | 1,623 | 1,456 | [
"DDInter980",
"DDInter1926"
] | Isavuconazonium | Venetoclax | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1623,
25,
1456
]
],
[
[
1623,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
1623,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
1623,
63,
86
],
[
86,
... | [
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Isavuconazonium may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Isavuconazonium may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderat... |
DB00963 | DB01082 | 1,263 | 1,448 | [
"DDInter241",
"DDInter1713"
] | Bromfenac | Streptomycin | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1263,
24,
1448
]
],
[
[
1263,
24,
1272
],
[
1272,
63,
1448
]
],
[
[
1263,
63,
91
],
[
91,
24,
1448
]
],
[
[
1263,
1,
935
],
[
935,
... | [
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
],
[
... | Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vanc... |
DB01218 | DB09420 | 1,493 | 1,074 | [
"DDInter852",
"DDInter953"
] | Halofantrine | Iodide I-123 | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1493,
24,
1074
]
],
[
[
1493,
62,
1247
],
[
1247,
24,
1074
]
],
[
[
1493,
25,
1487
],
[
1487,
24,
1074
]
],
[
[
1493,
64,
33
],
[
33,
... | [
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Halofantrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
]... | Halofantrine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Halofantrine may lead to a major life threatening interaction when taken with Hydroxychloroquine a... |
DB01176 | DB01367 | 537 | 1,163 | [
"DDInter453",
"DDInter1572"
] | Cyclizine | Rasagiline | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
537,
24,
1163
]
],
[
[
537,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
537,
63,
100
],
[
100,
24,
1163
]
],
[
[
537,
40,
830
],
[
830,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Cyclizine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused b... | Cyclizine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with R... |
DB00373 | DB00782 | 461 | 1,123 | [
"DDInter1809",
"DDInter1535"
] | Timolol | Propantheline | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
461,
24,
1123
]
],
[
[
461,
21,
28681
],
[
28681,
60,
1123
]
],
[
[
461,
24,
1192
],
[
1192,
63,
1123
]
],
[
[
461,
63,
999
],
[
999,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Timolol",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effe... | Timolol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Propantheline (Compound)
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when... |
DB00041 | DB00285 | 1,648 | 1,100 | [
"DDInter38",
"DDInter1927"
] | Aldesleukin | Venlafaxine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Moderate | 1 | [
[
[
1648,
24,
1100
]
],
[
[
1648,
25,
534
],
[
534,
1,
1100
]
],
[
[
1648,
24,
643
],
[
643,
40,
1100
]
],
[
[
1648,
24,
1555
],
[
1555,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
]
],
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
],
[
"Tramadol"... | Aldesleukin may lead to a major life threatening interaction when taken with Tramadol and Tramadol (Compound) resembles Venlafaxine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine (Compound) resembles Venlafaxine (Compound)
Aldesle... |
DB00218 | DB00757 | 1,176 | 1,166 | [
"DDInter1247",
"DDInter581"
] | Moxifloxacin | Dolasetron | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1176,
25,
1166
]
],
[
[
1176,
21,
28803
],
[
28803,
60,
1166
]
],
[
[
1176,
23,
112
],
[
112,
62,
1166
]
],
[
[
1176,
24,
688
],
[
688... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Anaemia"
],
[
"Anaemia",
"{u} (Side Effect) is caused by {v} (Comp... | Moxifloxacin (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Dolasetron (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Dolas... |
DB00934 | DB12332 | 413 | 1,619 | [
"DDInter1124",
"DDInter1626"
] | Maprotiline | Rucaparib | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
413,
24,
1619
]
],
[
[
413,
24,
222
],
[
222,
23,
1619
]
],
[
[
413,
62,
112
],
[
112,
23,
1619
]
],
[
[
413,
24,
1662
],
[
1662,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metr... |
DB00723 | DB01132 | 1,240 | 1,130 | [
"DDInter1176",
"DDInter1472"
] | Methoxamine | Pioglitazone | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
1240,
24,
1130
]
],
[
[
1240,
24,
688
],
[
688,
24,
1130
]
],
[
[
1240,
63,
1179
],
[
1179,
24,
1130
]
],
[
[
1240,
24,
1296
],
[
1296... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro an... |
DB00877 | DB11767 | 629 | 1,583 | [
"DDInter1678",
"DDInter1643"
] | Sirolimus | Sarilumab | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
629,
24,
1583
]
],
[
[
629,
62,
1461
],
[
1461,
23,
1583
]
],
[
[
629,
23,
1114
],
[
1114,
23,
1583
]
],
[
[
629,
64,
362
],
[
362,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Sirolimus",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"V... | Sirolimus may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Sirolimus may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate ma... |
DB01110 | DB06603 | 86 | 39 | [
"DDInter1209",
"DDInter1387"
] | Miconazole | Panobinostat | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
86,
24,
39
]
],
[
[
86,
62,
479
],
[
479,
23,
39
]
],
[
[
86,
63,
211
],
[
211,
23,
39
]
],
[
[
86,
24,
336
],
[
336,
24,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Miconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
... | Miconazole may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodi... |
DB01124 | DB01191 | 1,411 | 1,039 | [
"DDInter1828",
"DDInter518"
] | Tolbutamide | Dexfenfluramine | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1411,
24,
1039
]
],
[
[
1411,
24,
1529
],
[
1529,
64,
1039
]
],
[
[
1411,
6,
10215
],
[
10215,
45,
1039
]
],
[
[
1411,
24,
673
],
[
67... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may lead to a major life threatening interaction when taken with Dexfenfluramine
Tolbutamide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexfenfluramine (Compound)
Tolbutamide m... |
DB01122 | DB11921 | 158 | 1,019 | [
"DDInter61",
"DDInter492"
] | Ambenonium | Deflazacort | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
158,
24,
1019
]
],
[
[
158,
24,
1220
],
[
1220,
25,
1019
]
],
[
[
158,
63,
770
],
[
770,
25,
1019
]
],
[
[
158,
24,
1220
],
[
1220,
... | [
[
[
"Ambenonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Ambenonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Ambenonium may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may lead to a major life threatening interaction when taken with Deflazacort
Ambenonium may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide m... |
DB00675 | DB14509 | 888 | 1,399 | [
"DDInter1744",
"DDInter1081"
] | Tamoxifen | Lithium carbonate | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
888,
24,
1399
]
],
[
[
888,
25,
1374
],
[
1374,
24,
1399
]
],
[
[
888,
24,
820
],
[
820,
24,
1399
]
],
[
[
888,
63,
1010
],
[
1010,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abir... | Tamoxifen may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine m... |
DB00033 | DB00059 | 342 | 1,560 | [
"DDInter949",
"DDInter1404"
] | Interferon gamma-1b | Pegaspargase | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Moderate | 1 | [
[
[
342,
24,
1560
]
],
[
[
342,
24,
372
],
[
372,
63,
1560
]
],
[
[
342,
63,
1257
],
[
1257,
24,
1560
]
],
[
[
342,
25,
593
],
[
593,
... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegaspargase"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofara... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00357 | DB12825 | 1,051 | 1,375 | [
"DDInter71",
"DDInter1032"
] | Aminoglutethimide | Lefamulin | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1051,
24,
1375
]
],
[
[
1051,
24,
159
],
[
159,
63,
1375
]
],
[
[
1051,
24,
309
],
[
309,
24,
1375
]
],
[
[
1051,
62,
1101
],
[
1101,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Ix... |
DB00041 | DB00270 | 1,648 | 1,428 | [
"DDInter38",
"DDInter993"
] | Aldesleukin | Isradipine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Moderate | 1 | [
[
[
1648,
24,
1428
]
],
[
[
1648,
24,
376
],
[
376,
40,
1428
]
],
[
[
1648,
24,
1486
],
[
1486,
63,
1428
]
],
[
[
1648,
25,
770
],
[
770,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Isradipine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate inte... |
DB00342 | DB00674 | 1,181 | 1,516 | [
"DDInter1770",
"DDInter802"
] | Terfenadine | Galantamine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
1181,
24,
1516
]
],
[
[
1181,
24,
688
],
[
688,
63,
1516
]
],
[
[
1181,
63,
521
],
[
521,
24,
1516
]
],
[
[
1181,
25,
1487
],
[
1487,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Galantamine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Gose... |
DB00213 | DB01344 | 837 | 1,231 | [
"DDInter1388",
"DDInter1830"
] | Pantoprazole | Tolevamer | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
837,
24,
1231
]
],
[
[
837,
1,
660
],
[
660,
24,
1231
]
],
[
[
837,
24,
1596
],
[
1596,
63,
1231
]
],
[
[
837,
24,
1152
],
[
1152,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Pantoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Esomeprazole"
],
[
"Esomeprazole",
"{u} may cause a ... | Pantoprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exac... |
DB00816 | DB01069 | 1,674 | 401 | [
"DDInter1346",
"DDInter1533"
] | Orciprenaline | Promethazine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1674,
24,
401
]
],
[
[
1674,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1674,
24,
939
],
[
939,
24,
401
]
],
[
[
1674,
21,
28662
],
[
28662,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and B... |
DB01309 | DB14730 | 1,254 | 1,412 | [
"DDInter933",
"DDInter264"
] | Insulin glulisine | Calaspargase pegol | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1254,
24,
1412
]
],
[
[
1254,
24,
5
],
[
5,
24,
1412
]
],
[
[
1254,
63,
251
],
[
251,
24,
1412
]
],
[
[
1254,
63,
1101
],
[
1101,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lirag... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00067 | DB09268 | 317 | 1,662 | [
"DDInter1921",
"DDInter1464"
] | Vasopressin | Picosulfuric acid | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
317,
24,
1662
]
],
[
[
317,
24,
484
],
[
484,
63,
1662
]
],
[
[
317,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
317,
24,
1491
],
[
1491,
... | [
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Vasopressin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozant... |
DB00283 | DB00708 | 701 | 1,454 | [
"DDInter395",
"DDInter1718"
] | Clemastine | Sufentanil | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
701,
24,
1454
]
],
[
[
701,
24,
704
],
[
704,
40,
1454
]
],
[
[
701,
6,
8374
],
[
8374,
45,
1454
]
],
[
[
701,
21,
28658
],
[
28658,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sufentanil (Compound)
Clemastine (Compound) causes Vomiting (Side Effect) and Vomiting (Side... |
DB01035 | DB11834 | 1,401 | 1,303 | [
"DDInter1524",
"DDInter849"
] | Procainamide | Guselkumab | A derivative of procaine with less CNS action. | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
1401,
24,
1303
]
],
[
[
1401,
63,
58
],
[
58,
24,
1303
]
],
[
[
1401,
74,
608
],
[
608,
24,
1303
]
],
[
[
1401,
24,
270
],
[
270,
... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[... | Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Procainamide (Compound) resembles Lidocaine (Compound) and Procainamide may cause a moderate interaction that co... |
DB00471 | DB00675 | 201 | 888 | [
"DDInter1242",
"DDInter1744"
] | Montelukast | Tamoxifen | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
201,
24,
888
]
],
[
[
201,
6,
8374
],
[
8374,
45,
888
]
],
[
[
201,
7,
6952
],
[
6952,
46,
888
]
],
[
[
201,
21,
29152
],
[
29152,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tamoxifen (Compound)
Montelukast (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Tamoxifen (Compound)
Montelukast (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Tamoxifen (Compound)
Montelukas... |
DB00349 | DB01390 | 902 | 1,117 | [
"DDInter401",
"DDInter1683"
] | Clobazam | Sodium bicarbonate | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
902,
23,
1117
]
],
[
[
902,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
902,
63,
1018
],
[
1018,
23,
1117
]
],
[
[
902,
40,
1119
],
[
1119... | [
[
[
"Clobazam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Clobazam",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is caused... | Clobazam (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Sodium ... |
DB09030 | DB09065 | 840 | 760 | [
"DDInter1945",
"DDInter424"
] | Vorapaxar | Cobicistat | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
840,
25,
760
]
],
[
[
840,
63,
1230
],
[
1230,
23,
760
]
],
[
[
840,
64,
34
],
[
34,
24,
760
]
],
[
[
840,
25,
1421
],
[
1421,
6... | [
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
"Citalopram",... | Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Vorapaxar may lead to a major life threatening interaction when taken with Fosamprenavir and Fosamprenavir may caus... |
DB09098 | DB11952 | 98 | 800 | [
"DDInter1700",
"DDInter612"
] | Somatrem | Duvelisib | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
98,
24,
800
]
],
[
[
98,
24,
466
],
[
466,
62,
800
]
],
[
[
98,
63,
222
],
[
222,
23,
800
]
],
[
[
98,
63,
310
],
[
310,
24,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutram... |
DB00377 | DB00490 | 1,494 | 946 | [
"DDInter1382",
"DDInter254"
] | Palonosetron | Buspirone | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Major | 2 | [
[
[
1494,
25,
946
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
946
]
],
[
[
1494,
21,
29209
],
[
29209,
60,
946
]
],
[
[
1494,
24,
820
],
[
820,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Buspirone"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Busp... | Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Buspirone (Compound)
Palonosetron (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Buspirone (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and A... |
DB00861 | DB01099 | 914 | 1,272 | [
"DDInter551",
"DDInter744"
] | Diflunisal | Flucytosine | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
914,
24,
1272
]
],
[
[
914,
21,
29209
],
[
29209,
60,
1272
]
],
[
[
914,
24,
1448
],
[
1448,
24,
1272
]
],
[
[
914,
63,
599
],
[
599,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Diflunisal",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is cause... | Diflunisal (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Fluc... |
DB00468 | DB01177 | 1,424 | 77 | [
"DDInter1557",
"DDInter904"
] | Quinine | Idarubicin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1424,
24,
77
]
],
[
[
1424,
6,
6017
],
[
6017,
45,
77
]
],
[
[
1424,
7,
12111
],
[
12111,
46,
77
]
],
[
[
1424,
7,
5998
],
[
5998,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Quinine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Quinine (Compound) upregulates MSRA (Gene) and MSRA (Gene) is upregulated by Idarubicin (Compound)
Quinine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Idarubicin (Compound)
Quinine (Compound) causes H... |
DB09046 | DB09073 | 1,094 | 951 | [
"DDInter1201",
"DDInter1379"
] | Metreleptin | Palbociclib | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1094,
24,
951
]
],
[
[
1094,
24,
907
],
[
907,
62,
951
]
],
[
[
1094,
24,
1476
],
[
1476,
63,
951
]
],
[
[
1094,
63,
1671
],
[
1671,
... | [
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
],
[... | Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB01166 | DB12825 | 477 | 1,375 | [
"DDInter379",
"DDInter1032"
] | Cilostazol | Lefamulin | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
477,
24,
1375
]
],
[
[
477,
62,
112
],
[
112,
23,
1375
]
],
[
[
477,
24,
159
],
[
159,
63,
1375
]
],
[
[
477,
24,
659
],
[
659,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and La... |
DB00999 | DB11110 | 504 | 603 | [
"DDInter883",
"DDInter1115"
] | Hydrochlorothiazide | Magnesium citrate | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
504,
24,
603
]
],
[
[
504,
25,
57
],
[
57,
24,
603
]
],
[
[
504,
63,
870
],
[
870,
24,
603
]
],
[
[
504,
1,
1326
],
[
1326,
24,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Hydrochlorothiazide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"... | Hydrochlorothiazide may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00485 | DB01024 | 916 | 1,096 | [
"DDInter541",
"DDInter1252"
] | Dicloxacillin | Mycophenolic acid | One of the penicillins which is resistant to penicillinase. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
916,
24,
1096
]
],
[
[
916,
7,
9283
],
[
9283,
46,
1096
]
],
[
[
916,
18,
2293
],
[
2293,
57,
1096
]
],
[
[
916,
21,
28996
],
[
28996,... | [
[
[
"Dicloxacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Dicloxacillin",
"{u} (Compound) upregulates {v} (Gene)",
"UBR7"
],
[
"UBR7",
"{u} (Gene) is upregulate... | Dicloxacillin (Compound) upregulates UBR7 (Gene) and UBR7 (Gene) is upregulated by Mycophenolic acid (Compound)
Dicloxacillin (Compound) downregulates CLTC (Gene) and CLTC (Gene) is downregulated by Mycophenolic acid (Compound)
Dicloxacillin (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal... |
DB01064 | DB09038 | 1,148 | 1,450 | [
"DDInter987",
"DDInter636"
] | Isoprenaline | Empagliflozin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1148,
24,
1450
]
],
[
[
1148,
63,
461
],
[
461,
24,
1450
]
],
[
[
1148,
24,
659
],
[
659,
63,
1450
]
],
[
[
1148,
24,
872
],
[
872,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilan... |
DB00820 | DB12267 | 402 | 1,476 | [
"DDInter1736",
"DDInter233"
] | Tadalafil | Brigatinib | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
402,
24,
1476
]
],
[
[
402,
24,
951
],
[
951,
24,
1476
]
],
[
[
402,
24,
982
],
[
982,
63,
1476
]
],
[
[
402,
63,
1051
],
[
1051,
... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[
... | Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosid... |
DB00928 | DB01030 | 1,426 | 869 | [
"DDInter148",
"DDInter1835"
] | Azacitidine | Topotecan | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
1426,
24,
869
]
],
[
[
1426,
7,
5677
],
[
5677,
46,
869
]
],
[
[
1426,
18,
10084
],
[
10084,
46,
869
]
],
[
[
1426,
6,
5245
],
[
5245,... | [
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Azacitidine",
"{u} (Compound) upregulates {v} (Gene)",
"GADD45B"
],
[
"GADD45B",
"{u} (Gene) is upregulated by {... | Azacitidine (Compound) upregulates GADD45B (Gene) and GADD45B (Gene) is upregulated by Topotecan (Compound)
Azacitidine (Compound) downregulates SPR (Gene) and SPR (Gene) is upregulated by Topotecan (Compound)
Azacitidine (Compound) binds DNMT3A (Gene) and DNMT3A (Gene) is upregulated by Topotecan (Compound)
Azacitidin... |
DB00712 | DB01225 | 1,274 | 500 | [
"DDInter763",
"DDInter645"
] | Flurbiprofen | Enoxaparin | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Major | 2 | [
[
[
1274,
25,
500
]
],
[
[
1274,
21,
28804
],
[
28804,
60,
500
]
],
[
[
1274,
23,
297
],
[
297,
62,
500
]
],
[
[
1274,
63,
311
],
[
311,
... | [
[
[
"Flurbiprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) causes {v} (Side Effect)",
"Purpura"
],
[
"Purpura",
"{u} (Side Effect) is caused by {v} (Comp... | Flurbiprofen (Compound) causes Purpura (Side Effect) and Purpura (Side Effect) is caused by Enoxaparin (Compound)
Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Enoxaparin
Flurbiprof... |
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