drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00759 | DB08827 | 1,620 | 990 | [
"DDInter1783",
"DDInter1085"
] | Tetracycline | Lomitapide | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1620,
25,
990
]
],
[
[
1620,
6,
8374
],
[
8374,
45,
990
]
],
[
[
1620,
63,
126
],
[
126,
24,
990
]
],
[
[
1620,
63,
305
],
[
305,
... | [
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Tetracycline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Lom... | Tetracycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Tetracycline may c... |
DB00514 | DB01202 | 506 | 1,435 | [
"DDInter527",
"DDInter1046"
] | Dextromethorphan | Levetiracetam | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Moderate | 1 | [
[
[
506,
24,
1435
]
],
[
[
506,
6,
4973
],
[
4973,
45,
1435
]
],
[
[
506,
21,
28769
],
[
28769,
60,
1435
]
],
[
[
506,
63,
701
],
[
701,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levetiracetam"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v}... | Dextromethorphan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levetiracetam (Compound)
Dextromethorphan (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Levetiracetam (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases... |
DB01138 | DB09065 | 804 | 760 | [
"DDInter1726",
"DDInter424"
] | Sulfinpyrazone | Cobicistat | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
804,
24,
760
]
],
[
[
804,
62,
1101
],
[
1101,
23,
760
]
],
[
[
804,
63,
1195
],
[
1195,
24,
760
]
],
[
[
804,
24,
868
],
[
868,
... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
... | Sulfinpyrazone may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erl... |
DB00515 | DB09276 | 589 | 381 | [
"DDInter387",
"DDInter1682"
] | Cisplatin | Sodium aurothiomalate | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
589,
24,
381
]
],
[
[
589,
24,
1683
],
[
1683,
24,
381
]
],
[
[
589,
63,
491
],
[
491,
24,
381
]
],
[
[
589,
25,
375
],
[
375,
2... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterfe... |
DB00444 | DB06372 | 63 | 259 | [
"DDInter1765",
"DDInter1594"
] | Teniposide | Rilonacept | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
63,
24,
259
]
],
[
[
63,
63,
1461
],
[
1461,
23,
259
]
],
[
[
63,
24,
1619
],
[
1619,
63,
259
]
],
[
[
63,
24,
478
],
[
478,
24,... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib m... |
DB09039 | DB09068 | 1,670 | 1,427 | [
"DDInter629",
"DDInter1948"
] | Eliglustat | Vortioxetine | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1670,
24,
1427
]
],
[
[
1670,
24,
1320
],
[
1320,
63,
1427
]
],
[
[
1670,
63,
477
],
[
477,
24,
1427
]
],
[
[
1670,
25,
1604
],
[
1604... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostaz... |
DB11691 | DB12500 | 1,499 | 283 | [
"DDInter1258",
"DDInter714"
] | Naldemedine | Fedratinib | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1499,
24,
283
]
],
[
[
1499,
24,
351
],
[
351,
23,
283
]
],
[
[
1499,
63,
1593
],
[
1593,
23,
283
]
],
[
[
1499,
24,
1339
],
[
1339,
... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizot... |
DB00242 | DB00619 | 1,064 | 1,419 | [
"DDInter392",
"DDInter909"
] | Cladribine | Imatinib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Major | 2 | [
[
[
1064,
25,
1419
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
1419
]
],
[
[
1064,
6,
17404
],
[
17404,
45,
1419
]
],
[
[
1064,
21,
28847
],
[
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imatinib"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated by ... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Imatinib (Compound)
Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Imatinib (Compound)
Cladribine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Imati... |
DB11760 | DB15091 | 119 | 676 | [
"DDInter1742",
"DDInter1901"
] | Talazoparib | Upadacitinib | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
119,
25,
676
]
],
[
[
119,
63,
1430
],
[
1430,
24,
676
]
],
[
[
119,
24,
214
],
[
214,
24,
676
]
],
[
[
119,
64,
122
],
[
122,
2... | [
[
[
"Talazoparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipu... | Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib ... |
DB08865 | DB11915 | 1,593 | 1,293 | [
"DDInter448",
"DDInter1909"
] | Crizotinib | Valbenazine | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Major | 2 | [
[
[
1593,
25,
1293
]
],
[
[
1593,
63,
112
],
[
112,
23,
1293
]
],
[
[
1593,
24,
710
],
[
710,
63,
1293
]
],
[
[
1593,
64,
521
],
[
521,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valbenazine"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metron... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and ... |
DB00662 | DB01246 | 717 | 820 | [
"DDInter1873",
"DDInter45"
] | Trimethobenzamide | Alimemazine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
717,
24,
820
]
],
[
[
717,
24,
358
],
[
358,
24,
820
]
],
[
[
717,
63,
1236
],
[
1236,
24,
820
]
],
[
[
717,
24,
649
],
[
649,
1... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Ca... |
DB00564 | DB00719 | 1,236 | 1,219 | [
"DDInter293",
"DDInter149"
] | Carbamazepine | Azatadine | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1236,
24,
1219
]
],
[
[
1236,
63,
13
],
[
13,
24,
1219
]
],
[
[
1236,
24,
830
],
[
830,
1,
1219
]
],
[
[
1236,
1,
1506
],
[
1506,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Pheninda... |
DB00938 | DB01166 | 455 | 477 | [
"DDInter1635",
"DDInter379"
] | Salmeterol | Cilostazol | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
455,
24,
477
]
],
[
[
455,
6,
8374
],
[
8374,
45,
477
]
],
[
[
455,
21,
28688
],
[
28688,
60,
477
]
],
[
[
455,
63,
216
],
[
216,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Salmeterol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Salmeterol (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Cilostazol (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and ... |
DB00836 | DB06788 | 543 | 1,616 | [
"DDInter1088",
"DDInter864"
] | Loperamide | Histrelin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
543,
24,
1616
]
],
[
[
543,
24,
112
],
[
112,
23,
1616
]
],
[
[
543,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
543,
24,
623
],
[
623,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Ri... |
DB00696 | DB06706 | 826 | 468 | [
"DDInter665",
"DDInter985"
] | Ergotamine | Isometheptene | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Major | 2 | [
[
[
826,
25,
468
]
],
[
[
826,
6,
5214
],
[
5214,
45,
468
]
],
[
[
826,
25,
222
],
[
222,
24,
468
]
],
[
[
826,
64,
1466
],
[
1466,
... | [
[
[
"Ergotamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isometheptene"
]
],
[
[
"Ergotamine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)",
"Isom... | Ergotamine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Isometheptene (Compound)
Ergotamine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Ergotamine may lead to a ... |
DB00682 | DB00872 | 126 | 1,080 | [
"DDInter1951",
"DDInter438"
] | Warfarin | Conivaptan | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Minor | 0 | [
[
[
126,
23,
1080
]
],
[
[
126,
23,
700
],
[
700,
40,
1080
]
],
[
[
126,
24,
990
],
[
990,
40,
1080
]
],
[
[
126,
6,
8374
],
[
8374,
... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Conivaptan"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Atorvastatin"
],
[
"A... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Atorvastatin and Atorvastatin (Compound) resembles Conivaptan (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide and Lomitapide (Compound) resembles Conivaptan (Compound)
Wa... |
DB00867 | DB01177 | 1,052 | 77 | [
"DDInter1606",
"DDInter904"
] | Ritodrine | Idarubicin | Adrenergic beta-agonist used to control premature labor. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1052,
24,
77
]
],
[
[
1052,
7,
5999
],
[
5999,
46,
77
]
],
[
[
1052,
18,
2183
],
[
2183,
57,
77
]
],
[
[
1052,
24,
823
],
[
823,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Ritodrine",
"{u} (Compound) upregulates {v} (Gene)",
"DYRK3"
],
[
"DYRK3",
"{u} (Gene) is upregulated by {v} (Com... | Ritodrine (Compound) upregulates DYRK3 (Gene) and DYRK3 (Gene) is upregulated by Idarubicin (Compound)
Ritodrine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Idarubicin (Compound)
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole and ... |
DB01064 | DB01601 | 1,148 | 833 | [
"DDInter987",
"DDInter1089"
] | Isoprenaline | Lopinavir | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Moderate | 1 | [
[
[
1148,
24,
833
]
],
[
[
1148,
25,
1327
],
[
1327,
40,
833
]
],
[
[
1148,
24,
549
],
[
549,
63,
833
]
],
[
[
1148,
63,
1555
],
[
1555,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
]
],
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquina... | Isoprenaline may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exace... |
DB00564 | DB11834 | 1,236 | 1,303 | [
"DDInter293",
"DDInter849"
] | Carbamazepine | Guselkumab | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
1236,
24,
1303
]
],
[
[
1236,
25,
792
],
[
792,
24,
1303
]
],
[
[
1236,
63,
58
],
[
58,
24,
1303
]
],
[
[
1236,
24,
467
],
[
467,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
"Riv... | Carbamazepine may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may ... |
DB00468 | DB09082 | 1,424 | 659 | [
"DDInter1557",
"DDInter1934"
] | Quinine | Vilanterol | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1424,
24,
659
]
],
[
[
1424,
24,
1220
],
[
1220,
23,
659
]
],
[
[
1424,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1424,
24,
1296
],
[
1296,... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithr... |
DB00008 | DB08865 | 491 | 1,593 | [
"DDInter1407",
"DDInter448"
] | Peginterferon alfa-2a | Crizotinib | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
491,
24,
1593
]
],
[
[
491,
24,
1627
],
[
1627,
62,
1593
]
],
[
[
491,
24,
1060
],
[
1060,
63,
1593
]
],
[
[
491,
23,
450
],
[
450,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canna... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Crizotinib
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00615 | DB08882 | 690 | 1,281 | [
"DDInter1589",
"DDInter1070"
] | Rifabutin | Linagliptin | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
690,
24,
1281
]
],
[
[
690,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
690,
21,
28762
],
[
28762,
60,
1281
]
],
[
[
690,
63,
251
],
[
251,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Rifabutin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Linagliptin (Compound)
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Beta... |
DB00230 | DB01142 | 784 | 1,264 | [
"DDInter1516",
"DDInter593"
] | Pregabalin | Doxepin | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
784,
24,
1264
]
],
[
[
784,
24,
401
],
[
401,
24,
1264
]
],
[
[
784,
24,
649
],
[
649,
63,
1264
]
],
[
[
784,
21,
32601
],
[
32601,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofe... |
DB00853 | DB10316 | 1,686 | 334 | [
"DDInter1762",
"DDInter1248"
] | Temozolomide | Mumps virus strain B level jeryl lynn live antigen | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1686,
25,
334
]
],
[
[
1686,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1686,
24,
328
],
[
328,
25,
334
]
],
[
[
1686,
25,
908
],
[
908,
... | [
[
[
"Temozolomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Temozolomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Temozolomide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Mercapt... |
DB00010 | DB01124 | 1,649 | 1,411 | [
"DDInter1661",
"DDInter1828"
] | Sermorelin | Tolbutamide | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1649,
24,
1411
]
],
[
[
1649,
24,
959
],
[
959,
40,
1411
]
],
[
[
1649,
24,
1296
],
[
1296,
63,
1411
]
],
[
[
1649,
24,
1144
],
[
1144... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction... |
DB01229 | DB11943 | 973 | 255 | [
"DDInter1377",
"DDInter495"
] | Paclitaxel | Delafloxacin | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
973,
23,
255
]
],
[
[
973,
63,
63
],
[
63,
23,
255
]
],
[
[
973,
24,
1320
],
[
1320,
63,
255
]
],
[
[
973,
24,
913
],
[
913,
24,... | [
[
[
"Paclitaxel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix... |
DB00393 | DB11986 | 854 | 484 | [
"DDInter1295",
"DDInter648"
] | Nimodipine | Entrectinib | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
854,
24,
484
]
],
[
[
854,
24,
1478
],
[
1478,
24,
484
]
],
[
[
854,
1,
336
],
[
336,
24,
484
]
],
[
[
854,
24,
159
],
[
159,
63... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Nimodipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could ... |
DB00673 | DB14881 | 723 | 180 | [
"DDInter112",
"DDInter1329"
] | Aprepitant | Oliceridine | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
723,
25,
180
]
],
[
[
723,
24,
124
],
[
124,
24,
180
]
],
[
[
723,
25,
484
],
[
484,
24,
180
]
],
[
[
723,
63,
752
],
[
752,
24,... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
"Glasdegib"... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Aprepitant may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause... |
DB00631 | DB01097 | 372 | 1,377 | [
"DDInter405",
"DDInter1033"
] | Clofarabine | Leflunomide | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
372,
25,
1377
]
],
[
[
372,
6,
17404
],
[
17404,
45,
1377
]
],
[
[
372,
21,
29062
],
[
29062,
60,
1377
]
],
[
[
372,
63,
1461
],
[
146... | [
[
[
"Clofarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Clofarabine",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
"Leflun... | Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Leflunomide (Compound)
Clofarabine (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E an... |
DB06704 | DB08913 | 247 | 1,186 | [
"DDInter952",
"DDInter1561"
] | Iobenguane (I-131) | Radium Ra 223 dichloride | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
247,
24,
1186
]
],
[
[
247,
21,
28787
],
[
28787,
60,
1186
]
],
[
[
247,
24,
810
],
[
810,
63,
1186
]
],
[
[
247,
21,
28787
],
[
28787... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Iobenguane",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Iobenguane (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Iobenguane may cause a moderate interaction that could exacerbate diseas... |
DB00019 | DB00773 | 1,257 | 896 | [
"DDInter1405",
"DDInter702"
] | Pegfilgrastim | Etoposide | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
1257,
24,
896
]
],
[
[
1257,
24,
147
],
[
147,
23,
896
]
],
[
[
1257,
24,
1362
],
[
1362,
63,
896
]
],
[
[
1257,
24,
322
],
[
322,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Etoposide
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Ola... |
DB06176 | DB11796 | 1,342 | 1,612 | [
"DDInter1616",
"DDInter786"
] | Romidepsin | Fostemsavir | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1342,
24,
1612
]
],
[
[
1342,
24,
98
],
[
98,
23,
1612
]
],
[
[
1342,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
1342,
63,
1220
],
[
1220,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib ... |
DB06616 | DB09237 | 594 | 1,586 | [
"DDInter224",
"DDInter1045"
] | Bosutinib | Levamlodipine | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
594,
24,
1586
]
],
[
[
594,
63,
478
],
[
478,
24,
1586
]
],
[
[
594,
24,
1297
],
[
1297,
63,
1586
]
],
[
[
594,
24,
1478
],
[
1478,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilo... |
DB00006 | DB00686 | 942 | 383 | [
"DDInter217",
"DDInter1424"
] | Bivalirudin | Pentosan polysulfate | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Moderate | 1 | [
[
[
942,
24,
383
]
],
[
[
942,
24,
714
],
[
714,
63,
383
]
],
[
[
942,
25,
20
],
[
20,
24,
383
]
],
[
[
942,
25,
405
],
[
405,
63,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate
Bivalirudin may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplas... |
DB09407 | DB12035 | 853 | 943 | [
"DDInter1114",
"DDInter1641"
] | Magnesium chloride | Sarecycline | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
853,
24,
943
]
],
[
[
853,
24,
1473
],
[
1473,
63,
943
]
],
[
[
853,
24,
460
],
[
460,
24,
943
]
],
[
[
853,
63,
1283
],
[
1283,
... | [
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium ... | Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate and Magnesium gluconate may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Magnesium chloride may cause a moderate interaction that could exacerbate diseases wh... |
DB08879 | DB11003 | 632 | 748 | [
"DDInter173",
"DDInter100"
] | Belimumab | Anthrax vaccine | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
632,
24,
748
]
],
[
[
632,
25,
676
],
[
676,
63,
748
]
],
[
[
632,
63,
1683
],
[
1683,
24,
748
]
],
[
[
632,
64,
1057
],
[
1057,
... | [
[
[
"Belimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Belimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
"Upada... | Belimumab may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Belimumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab m... |
DB05273 | DB14811 | 507 | 385 | [
"DDInter1638",
"DDInter979"
] | Samarium (153Sm) lexidronam | Isatuximab | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Major | 2 | [
[
[
507,
25,
385
]
],
[
[
507,
25,
1362
],
[
1362,
24,
385
]
],
[
[
507,
64,
377
],
[
377,
24,
385
]
],
[
[
507,
24,
270
],
[
270,
2... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isatuximab"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Mitomycin and Mitomyc... |
DB00443 | DB00939 | 251 | 1,338 | [
"DDInter195",
"DDInter1135"
] | Betamethasone | Meclofenamic acid | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
251,
24,
1338
]
],
[
[
251,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
251,
6,
7720
],
[
7720,
45,
1338
]
],
[
[
251,
21,
28900
],
[
28900,... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicyli... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Betamethasone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Meclofena... |
DB09472 | DB11130 | 1,383 | 407 | [
"DDInter1693",
"DDInter1344"
] | Sodium sulfate | Opium | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1383,
24,
407
]
],
[
[
1383,
63,
529
],
[
529,
24,
407
]
],
[
[
1383,
24,
1267
],
[
1267,
63,
407
]
],
[
[
1383,
64,
576
],
[
576,
... | [
[
[
"Sodium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Sodium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvoxamine"
],
... | Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine an... |
DB00501 | DB01377 | 752 | 1,283 | [
"DDInter380",
"DDInter1119"
] | Cimetidine | Magnesium oxide | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
752,
23,
1283
]
],
[
[
752,
25,
684
],
[
684,
23,
1283
]
],
[
[
752,
63,
461
],
[
461,
23,
1283
]
],
[
[
752,
62,
831
],
[
831,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thior... | Cimetidine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause... |
DB00087 | DB05679 | 599 | 1,683 | [
"DDInter41",
"DDInter1907"
] | Alemtuzumab | Ustekinumab | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
599,
24,
1683
]
],
[
[
599,
24,
1042
],
[
1042,
24,
1683
]
],
[
[
599,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
599,
63,
305
],
[
305,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib a... |
DB00282 | DB01250 | 641 | 712 | [
"DDInter1383",
"DDInter1334"
] | Pamidronic acid | Olsalazine | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
641,
24,
712
]
],
[
[
641,
24,
50
],
[
50,
40,
712
]
],
[
[
641,
24,
416
],
[
416,
24,
712
]
],
[
[
641,
1,
1199
],
[
1199,
24,
... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
... | Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin may cause a moderate interact... |
DB01030 | DB06595 | 869 | 1,491 | [
"DDInter1835",
"DDInter1214"
] | Topotecan | Midostaurin | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
869,
24,
1491
]
],
[
[
869,
63,
58
],
[
58,
24,
1491
]
],
[
[
869,
24,
270
],
[
270,
63,
1491
]
],
[
[
869,
24,
1342
],
[
1342,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizu... |
DB00370 | DB09472 | 1,251 | 1,383 | [
"DDInter1230",
"DDInter1693"
] | Mirtazapine | Sodium sulfate | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1251,
24,
1383
]
],
[
[
1251,
24,
609
],
[
609,
24,
1383
]
],
[
[
1251,
63,
521
],
[
521,
24,
1383
]
],
[
[
1251,
25,
1133
],
[
1133,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Goserel... |
DB00047 | DB00902 | 176 | 104 | [
"DDInter932",
"DDInter1168"
] | Insulin glargine | Methdilazine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
176,
24,
104
]
],
[
[
176,
24,
820
],
[
820,
1,
104
]
],
[
[
176,
24,
401
],
[
401,
63,
104
]
],
[
[
176,
24,
417
],
[
417,
23,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate in... |
DB00434 | DB11186 | 13 | 1,609 | [
"DDInter459",
"DDInter1427"
] | Cyproheptadine | Pentoxyverine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
13,
24,
1609
]
],
[
[
13,
24,
314
],
[
314,
24,
1609
]
],
[
[
13,
63,
556
],
[
556,
24,
1609
]
],
[
[
13,
25,
306
],
[
306,
24,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Valproic a... |
DB00813 | DB01619 | 704 | 830 | [
"DDInter722",
"DDInter1441"
] | Fentanyl | Phenindamine | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
704,
24,
830
]
],
[
[
704,
40,
11286
],
[
11286,
1,
830
]
],
[
[
704,
35,
537
],
[
537,
40,
830
]
],
[
[
704,
63,
1219
],
[
1219,
... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Fentanyl",
"{u} (Compound) resembles {v} (Compound)",
"Diphenylpyraline"
],
[
"Diphenylpyraline",
"{u} (Compound... | Fentanyl (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles Phenindamine (Compound)
Fentanyl (Compound) resembles Cyclizine (Compound) and Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenind... |
DB00209 | DB01100 | 352 | 1,568 | [
"DDInter1886",
"DDInter1470"
] | Trospium | Pimozide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
352,
24,
1568
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1568
]
],
[
[
352,
21,
28921
],
[
28921,
60,
1568
]
],
[
[
352,
24,
19
],
[
19,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Trospium",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pimozide (Compound)
Trospium (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Pimozide (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine m... |
DB00687 | DB01203 | 870 | 699 | [
"DDInter747",
"DDInter1255"
] | Fludrocortisone | Nadolol | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
870,
24,
699
]
],
[
[
870,
24,
729
],
[
729,
1,
699
]
],
[
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870,
21,
29051
],
[
29051,
60,
699
]
],
[
[
870,
23,
1384
],
[
1384,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Fludrocortisone (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Nadolol (Compound)
Fludrocortisone may cause a ... |
DB01009 | DB01276 | 935 | 123 | [
"DDInter1009",
"DDInter706"
] | Ketoprofen | Exenatide | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
935,
24,
123
]
],
[
[
935,
63,
1573
],
[
1573,
24,
123
]
],
[
[
935,
24,
1039
],
[
1039,
24,
123
]
],
[
[
935,
40,
1263
],
[
1263,
... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and De... |
DB00736 | DB01242 | 660 | 1,237 | [
"DDInter676",
"DDInter410"
] | Esomeprazole | Clomipramine | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
660,
24,
1237
]
],
[
[
660,
63,
902
],
[
902,
40,
1237
]
],
[
[
660,
6,
8374
],
[
8374,
45,
1237
]
],
[
[
660,
21,
28703
],
[
28703,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clobazam"
],
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Clomipramine (Compound)
Esomeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clomipramine (Compound)
Esomeprazole (Compound) causes Pruritus (Side Effect) and Prur... |
DB00652 | DB08895 | 234 | 976 | [
"DDInter1421",
"DDInter1825"
] | Pentazocine | Tofacitinib | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
234,
24,
976
]
],
[
[
234,
25,
407
],
[
407,
63,
976
]
],
[
[
234,
64,
475
],
[
475,
24,
976
]
],
[
[
234,
63,
1512
],
[
1512,
2... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Pentazocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Opium"
],
[
"Opium",
... | Pentazocine may lead to a major life threatening interaction when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Pentazocine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction tha... |
DB00726 | DB09272 | 1,164 | 412 | [
"DDInter1876",
"DDInter632"
] | Trimipramine | Eluxadoline | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1164,
24,
412
]
],
[
[
1164,
63,
1594
],
[
1594,
24,
412
]
],
[
[
1164,
24,
543
],
[
543,
24,
412
]
],
[
[
1164,
1,
21
],
[
21,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and L... |
DB00006 | DB06779 | 942 | 365 | [
"DDInter217",
"DDInter470"
] | Bivalirudin | Dalteparin | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
942,
25,
365
]
],
[
[
942,
23,
539
],
[
539,
62,
365
]
],
[
[
942,
24,
1496
],
[
1496,
63,
365
]
],
[
[
942,
24,
1100
],
[
1100,
... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib m... |
DB00945 | DB11817 | 1,479 | 1,259 | [
"DDInter20",
"DDInter165"
] | Acetylsalicylic acid | Baricitinib | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
1479,
24,
1259
]
],
[
[
1479,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
1479,
63,
1274
],
[
1274,
24,
1259
]
],
[
[
1479,
24,
935
],
[
935... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitami... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Flur... |
DB00358 | DB01227 | 1,010 | 1,301 | [
"DDInter1140",
"DDInter1043"
] | Mefloquine | Levacetylmethadol | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
1010,
25,
1301
]
],
[
[
1010,
64,
494
],
[
494,
1,
1301
]
],
[
[
1010,
24,
675
],
[
675,
1,
1301
]
],
[
[
1010,
6,
10450
],
[
10450,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyramide"
],
[
"Disopyramide",
... | Mefloquine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Levacetylm... |
DB00358 | DB00593 | 1,010 | 1,464 | [
"DDInter1140",
"DDInter695"
] | Mefloquine | Ethosuximide | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Moderate | 1 | [
[
[
1010,
24,
1464
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1464
]
],
[
[
1010,
21,
28723
],
[
28723,
60,
1464
]
],
[
[
1010,
24,
401
],
[
40... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethosuximide"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethosuximide (Compound)
Mefloquine (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Ethosuximide (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Promethaz... |
DB05316 | DB14568 | 749 | 982 | [
"DDInter1467",
"DDInter1000"
] | Pimavanserin | Ivosidenib | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
749,
25,
982
]
],
[
[
749,
62,
112
],
[
112,
23,
982
]
],
[
[
749,
63,
1101
],
[
1101,
23,
982
]
],
[
[
749,
63,
543
],
[
543,
2... | [
[
[
"Pimavanserin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and ... |
DB01319 | DB09074 | 34 | 1,362 | [
"DDInter777",
"DDInter1327"
] | Fosamprenavir | Olaparib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
34,
25,
1362
]
],
[
[
34,
63,
2
],
[
2,
24,
1362
]
],
[
[
34,
25,
1478
],
[
1478,
24,
1362
]
],
[
[
34,
64,
467
],
[
467,
24,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alosetron"
],
[
"Alosetr... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Alosetron and Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Fosamprenavir may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause ... |
DB09280 | DB11718 | 1,604 | 927 | [
"DDInter1101",
"DDInter640"
] | Lumacaftor | Encorafenib | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
1604,
25,
927
]
],
[
[
1604,
63,
1005
],
[
1005,
24,
927
]
],
[
[
1604,
64,
946
],
[
946,
24,
927
]
],
[
[
1604,
25,
938
],
[
938,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Lumacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vardenafil"
],
[
"Vardenafi... | Lumacaftor may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Lumacaftor may lead to a major life threatening interaction when taken with Buspirone and Buspirone may cause a... |
DB00574 | DB01242 | 121 | 1,237 | [
"DDInter717",
"DDInter410"
] | Fenfluramine | Clomipramine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
121,
24,
1237
]
],
[
[
121,
25,
684
],
[
684,
1,
1237
]
],
[
[
121,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
121,
63,
902
],
[
902,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Th... | Fenfluramine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)... |
DB00254 | DB01144 | 964 | 1,326 | [
"DDInter598",
"DDInter540"
] | Doxycycline | Diclofenamide | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Minor | 0 | [
[
[
964,
23,
1326
]
],
[
[
964,
23,
504
],
[
504,
1,
1326
]
],
[
[
964,
23,
359
],
[
359,
40,
1326
]
],
[
[
964,
40,
1620
],
[
1620,
... | [
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Diclofenamide"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrochlorothiazide"
]... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Doxycycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resem... |
DB00213 | DB06626 | 837 | 263 | [
"DDInter1388",
"DDInter147"
] | Pantoprazole | Axitinib | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Minor | 0 | [
[
[
837,
23,
263
]
],
[
[
837,
1,
1215
],
[
1215,
23,
263
]
],
[
[
837,
24,
1335
],
[
1335,
24,
263
]
],
[
[
837,
63,
529
],
[
529,
... | [
[
[
"Pantoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Axitinib"
]
],
[
[
"Pantoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Lansoprazole"
],
[
"Lansoprazole",
"{u} may cause a min... | Pantoprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine may cause a moderate interaction ... |
DB00290 | DB00365 | 329 | 839 | [
"DDInter219",
"DDInter842"
] | Bleomycin | Grepafloxacin | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Minor | 0 | [
[
[
329,
23,
839
]
],
[
[
329,
24,
1488
],
[
1488,
62,
839
]
],
[
[
329,
24,
141
],
[
141,
23,
839
]
],
[
[
329,
63,
552
],
[
552,
2... | [
[
[
"Bleomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Grepafloxacin"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Flox... |
DB00912 | DB01365 | 473 | 280 | [
"DDInter1581",
"DDInter1151"
] | Repaglinide | Mephentermine | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
473,
24,
280
]
],
[
[
473,
63,
551
],
[
551,
1,
280
]
],
[
[
473,
24,
1161
],
[
1161,
1,
280
]
],
[
[
473,
24,
22
],
[
22,
40,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Mephentermine (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline (Compound) resembles Mephentermine (Co... |
DB01097 | DB01610 | 1,377 | 248 | [
"DDInter1033",
"DDInter1912"
] | Leflunomide | Valganciclovir | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
1377,
24,
248
]
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[
[
1377,
63,
563
],
[
563,
1,
248
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[
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29209
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[
29209,
60,
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[
[
1377,
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1101
],
[
1101,
... | [
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Leflunomide (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Leflunomide may lead to a major li... |
DB00938 | DB11642 | 455 | 938 | [
"DDInter1635",
"DDInter1480"
] | Salmeterol | Pitolisant | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
455,
24,
938
]
],
[
[
455,
25,
760
],
[
760,
24,
938
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],
[
[
455,
63,
600
],
[
600,
24,
938
]
],
[
[
455,
24,
1228
],
[
1228,
2... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Salmeterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
],
[
"Cobicistat... | Salmeterol may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may caus... |
DB00327 | DB01069 | 421 | 401 | [
"DDInter890",
"DDInter1533"
] | Hydromorphone | Promethazine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
421,
24,
401
]
],
[
[
421,
24,
1264
],
[
1264,
63,
401
]
],
[
[
421,
24,
104
],
[
104,
24,
401
]
],
[
[
421,
6,
12523
],
[
12523,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Me... |
DB00938 | DB05316 | 455 | 749 | [
"DDInter1635",
"DDInter1467"
] | Salmeterol | Pimavanserin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
455,
24,
749
]
],
[
[
455,
24,
1264
],
[
1264,
24,
749
]
],
[
[
455,
63,
521
],
[
521,
24,
749
]
],
[
[
455,
24,
594
],
[
594,
6... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Pimavanserin
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin m... |
DB06209 | DB14006 | 256 | 972 | [
"DDInter1508",
"DDInter370"
] | Prasugrel | Choline salicylate | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
256,
24,
972
]
],
[
[
256,
62,
660
],
[
660,
23,
972
]
],
[
[
256,
64,
553
],
[
553,
24,
972
]
],
[
[
256,
63,
885
],
[
885,
24,... | [
[
[
"Prasugrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Prasugrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
],
... | Prasugrel may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Prasugrel may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux ... |
DB01101 | DB06723 | 60 | 115 | [
"DDInter285",
"DDInter58"
] | Capecitabine | Aluminum hydroxide | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
60,
23,
115
]
],
[
[
60,
21,
29803
],
[
29803,
60,
115
]
],
[
[
60,
62,
1176
],
[
1176,
24,
115
]
],
[
[
60,
23,
1539
],
[
1539,
... | [
[
[
"Capecitabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Capecitabine",
"{u} (Compound) causes {v} (Side Effect)",
"Venous thrombosis"
],
[
"Venous thrombosis",
... | Capecitabine (Compound) causes Venous thrombosis (Side Effect) and Venous thrombosis (Side Effect) is caused by Aluminum hydroxide (Compound)
Capecitabine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin may cause a moderate interaction that could exacerbate di... |
DB06595 | DB06699 | 1,491 | 774 | [
"DDInter1214",
"DDInter493"
] | Midostaurin | Degarelix | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1491,
24,
774
]
],
[
[
1491,
63,
521
],
[
521,
1,
774
]
],
[
[
1491,
62,
112
],
[
112,
23,
774
]
],
[
[
1491,
63,
888
],
[
888,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Midostaurin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can l... |
DB00681 | DB01028 | 1,287 | 1,332 | [
"DDInter85",
"DDInter1179"
] | Amphotericin B | Methoxyflurane | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Moderate | 1 | [
[
[
1287,
24,
1332
]
],
[
[
1287,
24,
1448
],
[
1448,
63,
1332
]
],
[
[
1287,
63,
589
],
[
589,
24,
1332
]
],
[
[
1287,
24,
50
],
[
50,
... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxyflurane"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Cispl... |
DB01255 | DB08868 | 633 | 1,011 | [
"DDInter1078",
"DDInter737"
] | Lisdexamfetamine | Fingolimod | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
633,
25,
1011
]
],
[
[
633,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
633,
62,
112
],
[
112,
23,
1011
]
],
[
[
633,
24,
144
],
[
144,
... | [
[
[
"Lisdexamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Lisdexamfetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
... | Lisdexamfetamine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can ... |
DB01234 | DB04868 | 1,220 | 478 | [
"DDInter513",
"DDInter1293"
] | Dexamethasone | Nilotinib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1220,
25,
478
]
],
[
[
1220,
24,
1468
],
[
1468,
63,
478
]
],
[
[
1220,
5,
11555
],
[
11555,
44,
478
]
],
[
[
1220,
6,
6017
],
[
6017,... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
"Ponati... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Dexamethasone (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilo... |
DB00562 | DB01362 | 1,014 | 497 | [
"DDInter188",
"DDInter960"
] | Benzthiazide | Iohexol | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Moderate | 1 | [
[
[
1014,
24,
497
]
],
[
[
1014,
1,
323
],
[
323,
24,
497
]
],
[
[
1014,
40,
674
],
[
674,
24,
497
]
],
[
[
1014,
24,
891
],
[
891,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
]
],
[
[
"Benzthiazide",
"{u} (Compound) resembles {v} (Compound)",
"Bendroflumethiazide"
],
[
"Bendroflumethiazide",
"{u} ... | Benzthiazide (Compound) resembles Bendroflumethiazide (Compound) and Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Benzthiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate d... |
DB01170 | DB01234 | 1,150 | 1,220 | [
"DDInter846",
"DDInter513"
] | Guanethidine | Dexamethasone | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1150,
24,
1220
]
],
[
[
1150,
63,
870
],
[
870,
1,
1220
]
],
[
[
1150,
63,
175
],
[
175,
40,
1220
]
],
[
[
1150,
24,
617
],
[
617,
... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles... |
DB01142 | DB11901 | 1,264 | 913 | [
"DDInter593",
"DDInter107"
] | Doxepin | Apalutamide | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1264,
24,
913
]
],
[
[
1264,
63,
312
],
[
312,
23,
913
]
],
[
[
1264,
62,
112
],
[
112,
23,
913
]
],
[
[
1264,
24,
271
],
[
271,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
[
"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Doxepin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazol... |
DB00196 | DB00818 | 600 | 898 | [
"DDInter743",
"DDInter1538"
] | Fluconazole | Propofol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
600,
24,
898
]
],
[
[
600,
6,
6017
],
[
6017,
45,
898
]
],
[
[
600,
21,
28882
],
[
28882,
60,
898
]
],
[
[
600,
24,
1031
],
[
1031,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Fluconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Propofol (Compound)
Fluconazole (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Propofol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases wh... |
DB00218 | DB11986 | 1,176 | 484 | [
"DDInter1247",
"DDInter648"
] | Moxifloxacin | Entrectinib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1176,
25,
484
]
],
[
[
1176,
23,
112
],
[
112,
23,
484
]
],
[
[
1176,
1,
1539
],
[
1539,
24,
484
]
],
[
[
1176,
25,
774
],
[
774,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Moxifloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that ... |
DB00197 | DB00364 | 1,324 | 417 | [
"DDInter1881",
"DDInter1717"
] | Troglitazone | Sucralfate | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protec... | Moderate | 1 | [
[
[
1324,
24,
417
]
],
[
[
1324,
24,
1630
],
[
1630,
62,
417
]
],
[
[
1324,
24,
1152
],
[
1152,
23,
417
]
],
[
[
1324,
24,
956
],
[
956,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine an... |
DB00361 | DB01611 | 134 | 1,487 | [
"DDInter1939",
"DDInter893"
] | Vinorelbine | Hydroxychloroquine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
134,
24,
1487
]
],
[
[
134,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
134,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
134,
24,
663
],
[
663,... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (C... | Vinorelbine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Vinorelbine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB08904 | DB12839 | 375 | 919 | [
"DDInter342",
"DDInter1411"
] | Certolizumab pegol | Pegvaliase | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and _trans_-cinnamic acid . Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients wit... | Moderate | 1 | [
[
[
375,
24,
919
]
],
[
[
375,
63,
268
],
[
268,
24,
919
]
],
[
[
375,
64,
1560
],
[
1560,
24,
919
]
],
[
[
375,
63,
268
],
[
268,
6... | [
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegvaliase"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterfer... | Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Pegvaliase
Certolizumab pegol may lead to a major life threatening interaction when taken wit... |
DB04899 | DB06292 | 1,549 | 549 | [
"DDInter1282",
"DDInter474"
] | Nesiritide | Dapagliflozin | Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1549,
24,
549
]
],
[
[
1549,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1549,
63,
885
],
[
885,
24,
549
]
],
[
[
1549,
24,
1455
],
[
1455,
... | [
[
[
"Nesiritide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Nesiritide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Nesiritide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Nesiritide may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interacti... |
DB00242 | DB00995 | 1,064 | 1,112 | [
"DDInter392",
"DDInter139"
] | Cladribine | Auranofin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Major | 2 | [
[
[
1064,
25,
1112
]
],
[
[
1064,
7,
7720
],
[
7720,
46,
1112
]
],
[
[
1064,
18,
1848
],
[
1848,
57,
1112
]
],
[
[
1064,
21,
28709
],
[
28... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Auranofin"
]
],
[
[
"Cladribine",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Cladribine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Auranofin (Compound)
Cladribine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Auranofin (Compound)
Cladribine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by ... |
DB00554 | DB06822 | 1,027 | 802 | [
"DDInter1478",
"DDInter1812"
] | Piroxicam | Tinzaparin | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
1027,
25,
802
]
],
[
[
1027,
24,
222
],
[
222,
24,
802
]
],
[
[
1027,
24,
738
],
[
738,
63,
802
]
],
[
[
1027,
63,
305
],
[
305,
... | [
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirapar... |
DB00584 | DB01124 | 610 | 1,411 | [
"DDInter638",
"DDInter1828"
] | Enalapril | Tolbutamide | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
610,
24,
1411
]
],
[
[
610,
24,
959
],
[
959,
40,
1411
]
],
[
[
610,
63,
245
],
[
245,
40,
1411
]
],
[
[
610,
6,
4610
],
[
4610,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB00278 | DB06822 | 291 | 802 | [
"DDInter117",
"DDInter1812"
] | Argatroban | Tinzaparin | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
291,
25,
802
]
],
[
[
291,
23,
944
],
[
944,
62,
802
]
],
[
[
291,
24,
222
],
[
222,
24,
802
]
],
[
[
291,
24,
1427
],
[
1427,
6... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Argatroban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Argatroban may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine... |
DB00841 | DB01309 | 532 | 1,254 | [
"DDInter577",
"DDInter933"
] | Dobutamine | Insulin glulisine | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
532,
24,
1254
]
],
[
[
532,
63,
1645
],
[
1645,
24,
1254
]
],
[
[
532,
35,
480
],
[
480,
24,
1254
]
],
[
[
532,
24,
170
],
[
170,
... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
... | Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Dobutamine (Compound) resembles Formoterol (Compound) and Dobutamine may cause a moderate interaction that ... |
DB00712 | DB11943 | 1,274 | 255 | [
"DDInter763",
"DDInter495"
] | Flurbiprofen | Delafloxacin | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1274,
24,
255
]
],
[
[
1274,
63,
372
],
[
372,
23,
255
]
],
[
[
1274,
24,
397
],
[
397,
23,
255
]
],
[
[
1274,
63,
1512
],
[
1512,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin and ... |
DB00092 | DB10316 | 58 | 334 | [
"DDInter40",
"DDInter1248"
] | Alefacept | Mumps virus strain B level jeryl lynn live antigen | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
58,
25,
334
]
],
[
[
58,
24,
1042
],
[
1042,
24,
334
]
],
[
[
58,
24,
594
],
[
594,
25,
334
]
],
[
[
58,
63,
1057
],
[
1057,
25,... | [
[
[
"Alefacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetr... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Mumps virus strain B level jeryl lynn live antigen
Alefacept may cause a moderate interaction that could exacerbate ... |
DB00827 | DB00945 | 646 | 1,479 | [
"DDInter383",
"DDInter20"
] | Cinoxacin | Acetylsalicylic acid | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
646,
24,
1479
]
],
[
[
646,
6,
10612
],
[
10612,
45,
1479
]
],
[
[
646,
21,
29232
],
[
29232,
60,
1479
]
],
[
[
646,
24,
1283
],
[
128... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Cinoxacin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (C... | Cinoxacin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Acetylsalicylic acid (Compound)
Cinoxacin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Acetylsalicylic acid (Compound)
Cinoxacin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00065 | DB00108 | 581 | 1,066 | [
"DDInter923",
"DDInter1268"
] | Infliximab | Natalizumab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Major | 2 | [
[
[
581,
25,
1066
]
],
[
[
581,
23,
1114
],
[
1114,
62,
1066
]
],
[
[
581,
24,
949
],
[
949,
63,
1066
]
],
[
[
581,
25,
375
],
[
375,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Natalizumab"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulf... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Natalizumab
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani t... |
DB04855 | DB06603 | 540 | 39 | [
"DDInter602",
"DDInter1387"
] | Dronedarone | Panobinostat | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
540,
25,
39
]
],
[
[
540,
62,
112
],
[
112,
23,
39
]
],
[
[
540,
63,
912
],
[
912,
24,
39
]
],
[
[
540,
24,
578
],
[
578,
63,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Dronedarone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta... |
DB04575 | DB09228 | 35 | 687 | [
"DDInter1555",
"DDInter437"
] | Quinestrol | Conestat alfa | The 3-cyclopentyl ether of ethinyl estradiol. | C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibi... | Moderate | 1 | [
[
[
35,
24,
687
]
],
[
[
35,
40,
559
],
[
559,
24,
687
]
],
[
[
35,
1,
984
],
[
984,
24,
687
]
],
[
[
35,
25,
350
],
[
350,
25,
... | [
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conestat alfa"
]
],
[
[
"Quinestrol",
"{u} (Compound) resembles {v} (Compound)",
"Estrone"
],
[
"Estrone",
"{u} may cause a moderate i... | Quinestrol (Compound) resembles Estrone (Compound) and Estrone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Quinestrol (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Quines... |
DB00015 | DB06754 | 582 | 707 | [
"DDInter1585",
"DDInter471"
] | Reteplase | Danaparoid | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
582,
25,
707
]
],
[
[
582,
23,
944
],
[
944,
62,
707
]
],
[
[
582,
24,
298
],
[
298,
63,
707
]
],
[
[
582,
24,
901
],
[
901,
24,... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Danaparoid
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C may c... |
DB01072 | DB01261 | 915 | 170 | [
"DDInter129",
"DDInter1679"
] | Atazanavir | Sitagliptin | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
915,
24,
170
]
],
[
[
915,
6,
8374
],
[
8374,
45,
170
]
],
[
[
915,
21,
28850
],
[
28850,
60,
170
]
],
[
[
915,
24,
52
],
[
52,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Atazanavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Atazanavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Atazanavir (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and D... |
DB00631 | DB14811 | 372 | 385 | [
"DDInter405",
"DDInter979"
] | Clofarabine | Isatuximab | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
372,
24,
385
]
],
[
[
372,
24,
1362
],
[
1362,
24,
385
]
],
[
[
372,
63,
377
],
[
377,
24,
385
]
],
[
[
372,
1,
1488
],
[
1488,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin... |
DB00060 | DB01381 | 912 | 958 | [
"DDInter947",
"DDInter819"
] | Interferon beta-1a | Ginkgo biloba | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
912,
24,
958
]
],
[
[
912,
24,
126
],
[
126,
24,
958
]
],
[
[
912,
63,
1648
],
[
1648,
24,
958
]
],
[
[
912,
25,
593
],
[
593,
2... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Aldesl... |
DB01006 | DB01357 | 300 | 890 | [
"DDInter1040",
"DDInter1160"
] | Letrozole | Mestranol | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
300,
24,
890
]
],
[
[
300,
24,
35
],
[
35,
40,
890
]
],
[
[
300,
63,
380
],
[
380,
40,
890
]
],
[
[
300,
63,
559
],
[
559,
1,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
[
... | Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Mestranol (Compound)
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Mestr... |
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