drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00741 | DB09045 | 167 | 52 | [
"DDInter885",
"DDInter607"
] | Hydrocortisone | Dulaglutide | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
167,
24,
52
]
],
[
[
167,
24,
170
],
[
170,
23,
52
]
],
[
[
167,
24,
609
],
[
609,
24,
52
]
],
[
[
167,
1,
989
],
[
989,
24,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromyc... |
DB01073 | DB06186 | 1,488 | 1,439 | [
"DDInter745",
"DDInter969"
] | Fludarabine | Ipilimumab | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
1488,
24,
1439
]
],
[
[
1488,
24,
1060
],
[
1060,
63,
1439
]
],
[
[
1488,
63,
268
],
[
268,
24,
1439
]
],
[
[
1488,
24,
671
],
[
671,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Peg... |
DB06317 | DB08895 | 1,626 | 976 | [
"DDInter630",
"DDInter1825"
] | Elotuzumab | Tofacitinib | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1626,
25,
976
]
],
[
[
1626,
24,
200
],
[
200,
63,
976
]
],
[
[
1626,
24,
1430
],
[
1430,
24,
976
]
],
[
[
1626,
63,
563
],
[
563,
... | [
[
[
"Elotuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
"Can... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleuc... |
DB09074 | DB14783 | 1,362 | 287 | [
"DDInter1327",
"DDInter574"
] | Olaparib | Diroximel fumarate | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1362,
24,
287
]
],
[
[
1362,
63,
1101
],
[
1101,
24,
287
]
],
[
[
1362,
64,
384
],
[
384,
24,
287
]
],
[
[
1362,
24,
1583
],
[
1583,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Olaparib may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may ca... |
DB09082 | DB11901 | 659 | 913 | [
"DDInter1934",
"DDInter107"
] | Vilanterol | Apalutamide | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
659,
24,
913
]
],
[
[
659,
63,
600
],
[
600,
24,
913
]
],
[
[
659,
25,
877
],
[
877,
63,
913
]
],
[
[
659,
24,
1619
],
[
1619,
6... | [
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Vilanterol may lead to a major life threatening interaction when taken with Macimorelin and Macimorelin may c... |
DB00342 | DB00450 | 1,181 | 78 | [
"DDInter1770",
"DDInter603"
] | Terfenadine | Droperidol | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Major | 2 | [
[
[
1181,
25,
78
]
],
[
[
1181,
25,
1300
],
[
1300,
40,
78
]
],
[
[
1181,
25,
1568
],
[
1568,
1,
78
]
],
[
[
1181,
23,
112
],
[
112,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Haloperidol"
],
[
"Haloperidol",
"{... | Terfenadine may lead to a major life threatening interaction when taken with Haloperidol and Haloperidol (Compound) resembles Droperidol (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Pimozide and Pimozide (Compound) resembles Droperidol (Compound)
Terfenadine may cause a minor ... |
DB00585 | DB01377 | 1,127 | 1,283 | [
"DDInter1309",
"DDInter1119"
] | Nizatidine | Magnesium oxide | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
1127,
23,
1283
]
],
[
[
1127,
62,
831
],
[
831,
23,
1283
]
],
[
[
1127,
23,
1468
],
[
1468,
62,
1283
]
],
[
[
1127,
1,
1194
],
[
1194,... | [
[
[
"Nizatidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Nizatidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indomethacin"
],
[... | Nizatidine may cause a minor interaction that can limit clinical effects when taken with Indomethacin and Indomethacin may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Nizatidine may cause a minor interaction that can limit clinical effects when taken with Ponatinib and Pona... |
DB00370 | DB05812 | 1,251 | 1,374 | [
"DDInter1230",
"DDInter8"
] | Mirtazapine | Abiraterone | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1251,
24,
1374
]
],
[
[
1251,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
1251,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
1251,
23,
112
],
[
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Mirtazapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Mirtazapine (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Mirtazapine may cause a minor interaction that can limit clinical effects when... |
DB00095 | DB01157 | 66 | 304 | [
"DDInter623",
"DDInter1875"
] | Efalizumab | Trimetrexate | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Moderate | 1 | [
[
[
66,
24,
304
]
],
[
[
66,
63,
58
],
[
58,
24,
304
]
],
[
[
66,
24,
1270
],
[
1270,
63,
304
]
],
[
[
66,
24,
139
],
[
139,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimetrexate"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified p... |
DB00222 | DB00865 | 245 | 939 | [
"DDInter825",
"DDInter187"
] | Glimepiride | Benzphetamine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Moderate | 1 | [
[
[
245,
24,
939
]
],
[
[
245,
24,
1529
],
[
1529,
1,
939
]
],
[
[
245,
24,
1161
],
[
1161,
40,
939
]
],
[
[
245,
24,
401
],
[
401,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzphetamine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline (Compound) resembles Benzphetami... |
DB11130 | DB12161 | 407 | 730 | [
"DDInter1344",
"DDInter512"
] | Opium | Deutetrabenazine | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
407,
24,
730
]
],
[
[
407,
63,
100
],
[
100,
24,
730
]
],
[
[
407,
24,
1609
],
[
1609,
24,
730
]
],
[
[
407,
63,
104
],
[
104,
2... | [
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
[
... | Opium may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Opium may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine a... |
DB09351 | DB12267 | 722 | 1,476 | [
"DDInter1048",
"DDInter233"
] | Levobetaxolol (ophthalmic) | Brigatinib | (S)-betaxolol is the (S)-enantiomer of betaxolol. It is an enantiomer of a (R)-betaxolol. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
722,
24,
1476
]
],
[
[
722,
24,
1276
],
[
1276,
24,
1476
]
],
[
[
722,
63,
770
],
[
770,
24,
1476
]
],
[
[
722,
63,
1011
],
[
1011,
... | [
[
[
"Levobetaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Levobetaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
],
... | Levobetaxolol may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Levobetaxolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib and Alectinib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Levobe... |
DB00005 | DB00056 | 1,057 | 816 | [
"DDInter687",
"DDInter814"
] | Etanercept | Gemtuzumab ozogamicin | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Major | 2 | [
[
[
1057,
25,
816
]
],
[
[
1057,
25,
305
],
[
305,
24,
816
]
],
[
[
1057,
25,
869
],
[
869,
63,
816
]
],
[
[
1057,
24,
748
],
[
748,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemtuzumab ozogamicin"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Asparaginase Escherichia coli"
],
[
... | Etanercept may lead to a major life threatening interaction when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Gemtuzumab ozogamicin
Etanercept may lead to a major life threatening interaction when taken with To... |
DB00816 | DB01577 | 1,674 | 1,529 | [
"DDInter1346",
"DDInter1161"
] | Orciprenaline | Metamfetamine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1674,
24,
1529
]
],
[
[
1674,
24,
939
],
[
939,
40,
1529
]
],
[
[
1674,
63,
80
],
[
80,
40,
1529
]
],
[
[
1674,
24,
93
],
[
93,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Metam... |
DB00279 | DB01174 | 1,152 | 697 | [
"DDInter1074",
"DDInter1442"
] | Liothyronine | Phenobarbital | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1152,
24,
697
]
],
[
[
1152,
24,
759
],
[
759,
1,
697
]
],
[
[
1152,
63,
362
],
[
362,
1,
697
]
],
[
[
1152,
24,
536
],
[
536,
4... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Comp... |
DB00536 | DB11988 | 1,225 | 270 | [
"DDInter848",
"DDInter1321"
] | Guanidine | Ocrelizumab | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1225,
24,
270
]
],
[
[
1225,
24,
4
],
[
4,
24,
270
]
],
[
[
1225,
63,
599
],
[
599,
24,
270
]
],
[
[
1225,
64,
1064
],
[
1064,
2... | [
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
... | Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Guanidine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00618 | DB09146 | 1,572 | 489 | [
"DDInter498",
"DDInter978"
] | Demeclocycline | Iron sucrose | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1572,
24,
489
]
],
[
[
1572,
24,
260
],
[
260,
63,
489
]
],
[
[
1572,
1,
1669
],
[
1669,
24,
489
]
],
[
[
1572,
24,
954
],
[
954,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate a... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Ferrous sulfate anhydrous and Ferrous sulfate anhydrous may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Demeclocycline (Compound) resembles Minocycline (Compound) and Minocycline m... |
DB01234 | DB06710 | 1,220 | 1,546 | [
"DDInter513",
"DDInter1193"
] | Dexamethasone | Methyltestosterone | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
1220,
24,
1546
]
],
[
[
1220,
40,
1581
],
[
1581,
1,
1546
]
],
[
[
1220,
63,
312
],
[
312,
1,
1546
]
],
[
[
1220,
74,
155
],
[
155,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Testolactone"
],
[
"Testolactone",
"{u} (... | Dexamethasone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Methyltestosterone (Compound)
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone (Compound) resembles Methyltestosterone (Compound)
Dexamethasone (Compoun... |
DB01168 | DB01210 | 1,053 | 668 | [
"DDInter1526",
"DDInter1050"
] | Procarbazine | Levobunolol (ophthalmic) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Moderate | 1 | [
[
[
1053,
24,
668
]
],
[
[
1053,
63,
461
],
[
461,
1,
668
]
],
[
[
1053,
63,
688
],
[
688,
25,
668
]
],
[
[
1053,
24,
729
],
[
729,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levobunolol"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Levobunolol
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Levobunolol (Compound)
Procarbazine may cause a moderate interaction that could e... |
DB01009 | DB09122 | 935 | 1,613 | [
"DDInter1009",
"DDInter1409"
] | Ketoprofen | Peginterferon beta-1a | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
935,
24,
1613
]
],
[
[
935,
63,
1274
],
[
1274,
24,
1613
]
],
[
[
935,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
935,
25,
292
],
[
292,
... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Sodium... |
DB00434 | DB00486 | 13 | 1,614 | [
"DDInter459",
"DDInter1253"
] | Cyproheptadine | Nabilone | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
13,
24,
1614
]
],
[
[
13,
24,
530
],
[
530,
1,
1614
]
],
[
[
13,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
13,
63,
999
],
[
999,
2... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Cyproheptadine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Cyproheptadine m... |
DB00341 | DB00387 | 1,242 | 1,386 | [
"DDInter343",
"DDInter1528"
] | Cetirizine | Procyclidine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Moderate | 1 | [
[
[
1242,
24,
1386
]
],
[
[
1242,
40,
11268
],
[
11268,
1,
1386
]
],
[
[
1242,
24,
1105
],
[
1105,
1,
1386
]
],
[
[
1242,
24,
1376
],
[
13... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procyclidine"
]
],
[
[
"Cetirizine",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Compound) re... | Cetirizine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Procyclidine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Procyclidine (Compound)
Cetirizine may cause a moderat... |
DB00656 | DB01612 | 827 | 1,637 | [
"DDInter1851",
"DDInter92"
] | Trazodone | Amyl Nitrite | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
827,
24,
1637
]
],
[
[
827,
1,
252
],
[
252,
24,
1637
]
],
[
[
827,
63,
475
],
[
475,
24,
1637
]
],
[
[
827,
24,
401
],
[
401,
2... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Trazodone",
"{u} (Compound) resembles {v} (Compound)",
"Hydroxyzine"
],
[
"Hydroxyzine",
"{u} may cause a moder... | Trazodone (Compound) resembles Hydroxyzine (Compound) and Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could e... |
DB00308 | DB09156 | 347 | 777 | [
"DDInter901",
"DDInter964"
] | Ibutilide | Iopromide | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
347,
24,
777
]
],
[
[
347,
40,
17
],
[
17,
24,
777
]
],
[
[
347,
25,
485
],
[
485,
25,
777
]
],
[
[
347,
40,
17
],
[
17,
24,
... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Ibutilide",
"{u} (Compound) resembles {v} (Compound)",
"Sotalol"
],
[
"Sotalol",
"{u} may cause a moderate interac... | Ibutilide (Compound) resembles Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Ibutilide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may lead to a major life threatening interaction when taken with ... |
DB00530 | DB09048 | 1,195 | 555 | [
"DDInter667",
"DDInter1284"
] | Erlotinib | Netupitant | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
1195,
24,
555
]
],
[
[
1195,
63,
1101
],
[
1101,
23,
555
]
],
[
[
1195,
24,
384
],
[
384,
62,
555
]
],
[
[
1195,
63,
1324
],
[
1324,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib... |
DB01234 | DB11853 | 1,220 | 230 | [
"DDInter513",
"DDInter1577"
] | Dexamethasone | Relugolix | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
1220,
24,
230
]
],
[
[
1220,
24,
129
],
[
129,
23,
230
]
],
[
[
1220,
63,
1101
],
[
1101,
23,
230
]
],
[
[
1220,
25,
1476
],
[
1476,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and... |
DB00015 | DB00554 | 582 | 1,027 | [
"DDInter1585",
"DDInter1478"
] | Reteplase | Piroxicam | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Moderate | 1 | [
[
[
582,
24,
1027
]
],
[
[
582,
24,
1171
],
[
1171,
1,
1027
]
],
[
[
582,
24,
222
],
[
222,
63,
1027
]
],
[
[
582,
64,
1578
],
[
1578,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) resembles Piroxicam (Compound)
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could ex... |
DB01263 | DB11921 | 859 | 1,019 | [
"DDInter1494",
"DDInter492"
] | Posaconazole | Deflazacort | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
859,
25,
1019
]
],
[
[
859,
63,
959
],
[
959,
24,
1019
]
],
[
[
859,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
859,
24,
761
],
[
761,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
"Glipiz... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruca... |
DB00283 | DB00765 | 701 | 1,266 | [
"DDInter395",
"DDInter1205"
] | Clemastine | Metyrosine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Moderate | 1 | [
[
[
701,
24,
1266
]
],
[
[
701,
21,
28762
],
[
28762,
60,
1266
]
],
[
[
701,
24,
662
],
[
662,
24,
1266
]
],
[
[
701,
24,
401
],
[
401,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metyrosine"
]
],
[
[
"Clemastine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused... | Clemastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Metyrosine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Met... |
DB01030 | DB09570 | 869 | 1,480 | [
"DDInter1835",
"DDInter1002"
] | Topotecan | Ixazomib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
869,
24,
1480
]
],
[
[
869,
24,
987
],
[
987,
63,
1480
]
],
[
[
869,
63,
440
],
[
440,
24,
1480
]
],
[
[
869,
24,
248
],
[
248,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR str... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Topotecan may cause a moderate interactio... |
DB11988 | DB14811 | 270 | 385 | [
"DDInter1321",
"DDInter979"
] | Ocrelizumab | Isatuximab | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
270,
24,
385
]
],
[
[
270,
63,
1362
],
[
1362,
24,
385
]
],
[
[
270,
64,
908
],
[
908,
25,
385
]
],
[
[
270,
25,
676
],
[
676,
6... | [
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Ocrelizumab may lead to a major life threatening interaction when taken with Golimumab and Golimumab may lead to a ... |
DB08908 | DB09122 | 713 | 1,613 | [
"DDInter564",
"DDInter1409"
] | Dimethyl fumarate | Peginterferon beta-1a | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
713,
24,
1613
]
],
[
[
713,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
713,
24,
975
],
[
975,
63,
1613
]
],
[
[
713,
63,
168
],
[
168,
... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ca... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken... |
DB01168 | DB13139 | 1,053 | 1,032 | [
"DDInter1526",
"DDInter1063"
] | Procarbazine | Levosalbutamol | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1053,
24,
1032
]
],
[
[
1053,
37,
1090
],
[
1090,
24,
1032
]
],
[
[
1053,
64,
121
],
[
121,
24,
1032
]
],
[
[
1053,
25,
22
],
[
22,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major ... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline and Procarbazine may lead to a major life threatening interaction when taken with Tetryzoline and Tetryzoline may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Procarbazi... |
DB01010 | DB01057 | 61 | 1,318 | [
"DDInter622",
"DDInter615"
] | Edrophonium | Echothiophate (ophthalmic) | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | Moderate | 1 | [
[
[
61,
24,
1318
]
],
[
[
61,
6,
5765
],
[
5765,
45,
1318
]
],
[
[
61,
21,
29166
],
[
29166,
60,
1318
]
],
[
[
61,
6,
10558
],
[
10558,
... | [
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Echothiophate"
]
],
[
[
"Edrophonium",
"{u} (Compound) binds {v} (Gene)",
"ACHE"
],
[
"ACHE",
"{u} (Gene) is bound by {v} (Compound)"... | Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Echothiophate
Edrophonium (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Echothiophate (Compound)
Edrophonium (Compound) causes Lacrimation increased (Side Effect) and Lacrimation increased (Side Effect) is caused by E... |
DB01142 | DB01381 | 1,264 | 958 | [
"DDInter593",
"DDInter819"
] | Doxepin | Ginkgo biloba | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1264,
24,
958
]
],
[
[
1264,
63,
126
],
[
126,
24,
958
]
],
[
[
1264,
24,
129
],
[
129,
63,
958
]
],
[
[
1264,
25,
593
],
[
593,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamid... |
DB00023 | DB09123 | 305 | 1,525 | [
"DDInter127",
"DDInter546"
] | Asparaginase Escherichia coli | Dienogest | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in... | Moderate | 1 | [
[
[
305,
24,
1525
]
],
[
[
305,
25,
1064
],
[
1064,
24,
1525
]
],
[
[
305,
24,
980
],
[
980,
24,
1525
]
],
[
[
305,
24,
484
],
[
484,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dienogest"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladr... | Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Dienogest
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01206 | DB10429 | 37 | 200 | [
"DDInter1086",
"DDInter282"
] | Lomustine | Candida albicans | An alkylating agent of value against both hematologic malignancies and solid tumors. | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
37,
24,
200
]
],
[
[
37,
24,
1683
],
[
1683,
24,
200
]
],
[
[
37,
25,
976
],
[
976,
24,
200
]
],
[
[
37,
63,
869
],
[
869,
24,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Lomustine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00241 | DB11703 | 288 | 405 | [
"DDInter257",
"DDInter9"
] | Butalbital | Acalabrutinib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
288,
24,
405
]
],
[
[
288,
23,
1101
],
[
1101,
24,
405
]
],
[
[
288,
24,
951
],
[
951,
24,
405
]
],
[
[
288,
24,
1297
],
[
1297,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Butalbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Butalbital may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palb... |
DB01240 | DB12364 | 885 | 1,421 | [
"DDInter657",
"DDInter200"
] | Epoprostenol | Betrixaban | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
885,
25,
1421
]
],
[
[
885,
23,
944
],
[
944,
62,
1421
]
],
[
[
885,
23,
539
],
[
539,
23,
1421
]
],
[
[
885,
63,
529
],
[
529,
... | [
[
[
"Epoprostenol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Epoprostenol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile... | Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may... |
DB00476 | DB01619 | 109 | 830 | [
"DDInter608",
"DDInter1441"
] | Duloxetine | Phenindamine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
109,
24,
830
]
],
[
[
109,
24,
537
],
[
537,
40,
830
]
],
[
[
109,
63,
13
],
[
13,
24,
830
]
],
[
[
109,
24,
104
],
[
104,
1,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction th... |
DB01156 | DB01598 | 593 | 483 | [
"DDInter252",
"DDInter911"
] | Bupropion | Imipenem | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include [meropenem], known for having greater activity ... | Major | 2 | [
[
[
593,
25,
483
]
],
[
[
593,
18,
4930
],
[
4930,
57,
483
]
],
[
[
593,
63,
126
],
[
126,
24,
483
]
],
[
[
593,
64,
1503
],
[
1503,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imipenem"
]
],
[
[
"Bupropion",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (Compound)",
"I... | Bupropion (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Imipenem (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Imipenem
Bupropion may lead... |
DB00011 | DB01381 | 1,451 | 958 | [
"DDInter944",
"DDInter819"
] | Interferon alfa-n1 | Ginkgo biloba | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1451,
24,
958
]
],
[
[
1451,
24,
126
],
[
126,
24,
958
]
],
[
[
1451,
25,
1648
],
[
1648,
24,
958
]
],
[
[
1451,
63,
491
],
[
491,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Interferon alfa-n1 may lead to a major life threatening interaction when taken with Aldesleukin and Aldes... |
DB00078 | DB10315 | 1,172 | 1,137 | [
"DDInter898",
"DDInter1127"
] | Ibritumomab tiuxetan | Measles virus vaccine live attenuated | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1172,
25,
1137
]
],
[
[
1172,
25,
273
],
[
273,
25,
1137
]
],
[
[
1172,
64,
581
],
[
581,
25,
1137
]
],
[
[
1172,
24,
384
],
[
384,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tositumoma... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Tositumomab and Tositumomab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Infliximab and In... |
DB01057 | DB09488 | 1,318 | 103 | [
"DDInter615",
"DDInter23"
] | Echothiophate (ophthalmic) | Acrivastine | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1318,
24,
103
]
],
[
[
1318,
24,
537
],
[
537,
24,
103
]
],
[
[
1318,
63,
104
],
[
104,
24,
103
]
],
[
[
1318,
24,
537
],
[
537,
... | [
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Echo... |
DB06228 | DB12500 | 792 | 283 | [
"DDInter1609",
"DDInter714"
] | Rivaroxaban | Fedratinib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
792,
25,
283
]
],
[
[
792,
24,
466
],
[
466,
62,
283
]
],
[
[
792,
24,
351
],
[
351,
23,
283
]
],
[
[
792,
63,
122
],
[
122,
23,... | [
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolu... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ri... |
DB01234 | DB01396 | 1,220 | 1,482 | [
"DDInter513",
"DDInter553"
] | Dexamethasone | Digitoxin | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
1220,
24,
1482
]
],
[
[
1220,
63,
1252
],
[
1252,
1,
1482
]
],
[
[
1220,
6,
8374
],
[
8374,
45,
1482
]
],
[
[
1220,
7,
2719
],
[
2719,... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Dexamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digitoxin (Compound)
Dexamethasone (Compound) upregulates ATP1A1 (Gene) and ATP1A1 (Gene)... |
DB09074 | DB15233 | 1,362 | 1,650 | [
"DDInter1327",
"DDInter142"
] | Olaparib | Avapritinib | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
1362,
24,
1650
]
],
[
[
1362,
63,
1478
],
[
1478,
24,
1650
]
],
[
[
1362,
24,
159
],
[
159,
24,
1650
]
],
[
[
1362,
64,
908
],
[
908,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrec... |
DB01118 | DB11978 | 33 | 124 | [
"DDInter76",
"DDInter822"
] | Amiodarone | Glasdegib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
33,
25,
124
]
],
[
[
33,
23,
1135
],
[
1135,
23,
124
]
],
[
[
33,
63,
112
],
[
112,
23,
124
]
],
[
[
33,
23,
466
],
[
466,
62,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Amiodarone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidaz... |
DB00894 | DB08889 | 1,581 | 350 | [
"DDInter1774",
"DDInter299"
] | Testolactone | Carfilzomib | An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer. | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Major | 2 | [
[
[
1581,
25,
350
]
],
[
[
1581,
21,
28658
],
[
28658,
60,
350
]
],
[
[
1581,
24,
4
],
[
4,
24,
350
]
],
[
[
1581,
24,
687
],
[
687,
... | [
[
[
"Testolactone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
]
],
[
[
"Testolactone",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {v} (C... | Testolactone (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Carfilzomib (Compound)
Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate... |
DB00980 | DB01110 | 969 | 86 | [
"DDInter1564",
"DDInter1209"
] | Ramelteon | Miconazole | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
969,
24,
86
]
],
[
[
969,
6,
10215
],
[
10215,
45,
86
]
],
[
[
969,
21,
28809
],
[
28809,
60,
86
]
],
[
[
969,
24,
222
],
[
222,
... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Ramelteon",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",... | Ramelteon (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Ramelteon (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Miconazole (Compound)
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibu... |
DB06168 | DB06616 | 1,531 | 594 | [
"DDInter281",
"DDInter224"
] | Canakinumab | Bosutinib | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1531,
24,
594
]
],
[
[
1531,
24,
713
],
[
713,
63,
594
]
],
[
[
1531,
63,
663
],
[
663,
24,
594
]
],
[
[
1531,
24,
1250
],
[
1250,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
],
... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Methot... |
DB00603 | DB05679 | 303 | 1,683 | [
"DDInter1137",
"DDInter1907"
] | Medroxyprogesterone acetate | Ustekinumab | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
303,
24,
1683
]
],
[
[
303,
24,
1093
],
[
1093,
63,
1683
]
],
[
[
303,
63,
305
],
[
305,
24,
1683
]
],
[
[
303,
24,
478
],
[
478,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases wh... |
DB00686 | DB12364 | 383 | 1,421 | [
"DDInter1424",
"DDInter200"
] | Pentosan polysulfate | Betrixaban | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
383,
24,
1421
]
],
[
[
383,
24,
765
],
[
765,
24,
1421
]
],
[
[
383,
24,
714
],
[
714,
25,
1421
]
],
[
[
383,
63,
291
],
[
291,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
... | Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Iloprost an... |
DB06603 | DB14723 | 39 | 159 | [
"DDInter1387",
"DDInter1026"
] | Panobinostat | Larotrectinib | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
39,
24,
159
]
],
[
[
39,
62,
479
],
[
479,
23,
159
]
],
[
[
39,
64,
318
],
[
318,
23,
159
]
],
[
[
39,
25,
1375
],
[
1375,
24,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Panobinostat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
... | Panobinostat may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Panobinostat may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may c... |
DB06206 | DB06822 | 1,268 | 802 | [
"DDInter1719",
"DDInter1812"
] | Sugammadex | Tinzaparin | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
1268,
24,
802
]
],
[
[
1268,
24,
1409
],
[
1409,
25,
802
]
],
[
[
1268,
63,
553
],
[
553,
25,
802
]
],
[
[
1268,
24,
498
],
[
498,
... | [
[
[
"Sugammadex",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Sugammadex",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
],
[
... | Sugammadex may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may lead to a major life threatening interaction when taken with Tinzaparin
Sugammadex may cause a moderate interaction that could exacerbate diseases when taken with Fondaparinux and Fondaparinux may lead t... |
DB00035 | DB00454 | 1,314 | 1,349 | [
"DDInter507",
"DDInter1150"
] | Desmopressin | Meperidine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Moderate | 1 | [
[
[
1314,
24,
1349
]
],
[
[
1314,
24,
901
],
[
901,
1,
1349
]
],
[
[
1314,
21,
28717
],
[
28717,
60,
1349
]
],
[
[
1314,
24,
1532
],
[
153... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meperidine"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Meperidine (Compound)
Desmopressin (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Meperidine (Compound)
Desmopressin may cause a moderate intera... |
DB00317 | DB01254 | 883 | 1,213 | [
"DDInter810",
"DDInter484"
] | Gefitinib | Dasatinib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
883,
24,
1213
]
],
[
[
883,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
883,
7,
3422
],
[
3422,
46,
1213
]
],
[
[
883,
18,
4729
],
[
4729,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Gefitinib (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Gefitinib (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Dasatinib (Compound)
Gefitinib (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dasatinib (Compound)
Gefitinib (Compo... |
DB05679 | DB08870 | 1,683 | 850 | [
"DDInter1907",
"DDInter228"
] | Ustekinumab | Brentuximab vedotin | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1683,
24,
850
]
],
[
[
1683,
24,
496
],
[
496,
63,
850
]
],
[
[
1683,
63,
611
],
[
611,
24,
850
]
],
[
[
1683,
25,
1583
],
[
1583,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vacc... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Ustekinumab may cause a moderate interaction that could exacerbate diseases when tak... |
DB01339 | DB09407 | 728 | 853 | [
"DDInter1922",
"DDInter1114"
] | Vecuronium | Magnesium chloride | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide ad... | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
728,
24,
853
]
],
[
[
728,
63,
964
],
[
964,
24,
853
]
],
[
[
728,
40,
1610
],
[
1610,
24,
853
]
],
[
[
728,
1,
1579
],
[
1579,
... | [
[
[
"Vecuronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Vecuronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
],... | Vecuronium may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Vecuronium (Compound) resembles Rocuronium (Compound) and Rocuronium may cause a moderate interaction ... |
DB00414 | DB01039 | 590 | 535 | [
"DDInter16",
"DDInter718"
] | Acetohexamide | Fenofibrate | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Moderate | 1 | [
[
[
590,
24,
535
]
],
[
[
590,
63,
831
],
[
831,
1,
535
]
],
[
[
590,
24,
629
],
[
629,
24,
535
]
],
[
[
590,
24,
1296
],
[
1296,
63... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibrate"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indomethacin"
],... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Fenofibrate (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction t... |
DB00047 | DB00808 | 176 | 1,605 | [
"DDInter932",
"DDInter916"
] | Insulin glargine | Indapamide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
176,
24,
1605
]
],
[
[
176,
24,
811
],
[
811,
1,
1605
]
],
[
[
176,
24,
1669
],
[
1669,
62,
1605
]
],
[
[
176,
24,
964
],
[
964,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and Minocycline may cause a minor interaction... |
DB00358 | DB09330 | 1,010 | 985 | [
"DDInter1140",
"DDInter1352"
] | Mefloquine | Osimertinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1010,
25,
985
]
],
[
[
1010,
23,
1247
],
[
1247,
23,
985
]
],
[
[
1010,
63,
608
],
[
608,
23,
985
]
],
[
[
1010,
24,
1478
],
[
1478,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfa... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine an... |
DB00631 | DB01095 | 372 | 671 | [
"DDInter405",
"DDInter769"
] | Clofarabine | Fluvastatin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
372,
24,
671
]
],
[
[
372,
24,
788
],
[
788,
40,
671
]
],
[
[
372,
24,
14
],
[
14,
63,
671
]
],
[
[
372,
7,
7720
],
[
7720,
46,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction... |
DB00486 | DB06204 | 1,614 | 768 | [
"DDInter1253",
"DDInter1746"
] | Nabilone | Tapentadol | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Moderate | 1 | [
[
[
1614,
24,
768
]
],
[
[
1614,
21,
29727
],
[
29727,
60,
768
]
],
[
[
1614,
24,
717
],
[
717,
24,
768
]
],
[
[
1614,
63,
999
],
[
999,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tapentadol"
]
],
[
[
"Nabilone",
"{u} (Compound) causes {v} (Side Effect)",
"Memory impairment"
],
[
"Memory impairment",
"{u} (Side Eff... | Nabilone (Compound) causes Memory impairment (Side Effect) and Memory impairment (Side Effect) is caused by Tapentadol (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide may cause a moderate interaction that could exacerbate diseas... |
DB00270 | DB08816 | 1,428 | 578 | [
"DDInter993",
"DDInter1802"
] | Isradipine | Ticagrelor | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Minor | 0 | [
[
[
1428,
23,
578
]
],
[
[
1428,
6,
8374
],
[
8374,
45,
578
]
],
[
[
1428,
21,
28646
],
[
28646,
60,
578
]
],
[
[
1428,
1,
336
],
[
336,
... | [
[
[
"Isradipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
]
],
[
[
"Isradipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Isradipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Isradipine (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Isradipine (Compound) re... |
DB00939 | DB01166 | 1,338 | 477 | [
"DDInter1135",
"DDInter379"
] | Meclofenamic acid | Cilostazol | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1338,
24,
477
]
],
[
[
1338,
21,
29340
],
[
29340,
60,
477
]
],
[
[
1338,
64,
126
],
[
126,
23,
477
]
],
[
[
1338,
24,
936
],
[
936,
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Meclofenamic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Stevens-Johnson syndrome"
],
[
"Stevens-Johnson... | Meclofenamic acid (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Cilostazol (Compound)
Meclofenamic acid may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects ... |
DB00950 | DB12035 | 1,413 | 943 | [
"DDInter732",
"DDInter1641"
] | Fexofenadine | Sarecycline | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1413,
24,
943
]
],
[
[
1413,
24,
1456
],
[
1456,
24,
943
]
],
[
[
1413,
24,
971
],
[
971,
63,
943
]
],
[
[
1413,
40,
543
],
[
543,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
],
... | Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and... |
DB06589 | DB10315 | 1,250 | 1,137 | [
"DDInter1400",
"DDInter1127"
] | Pazopanib | Measles virus vaccine live attenuated | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1250,
25,
1137
]
],
[
[
1250,
63,
617
],
[
617,
24,
1137
]
],
[
[
1250,
64,
581
],
[
581,
25,
1137
]
],
[
[
1250,
25,
384
],
[
384,
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Pazopanib may lead to a major life threatening interaction when taken with Infliximab ... |
DB00934 | DB06704 | 413 | 247 | [
"DDInter1124",
"DDInter951"
] | Maprotiline | Iobenguane (I-123) | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
413,
37,
247
]
],
[
[
413,
6,
7390
],
[
7390,
45,
247
]
],
[
[
413,
18,
9205
],
[
9205,
57,
247
]
],
[
[
413,
21,
28787
],
[
28787,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"SLC6... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Maprotiline may lead to a major life threatening interaction when taken with Iobenguane
Maprotiline (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Maprotiline (Compound) downreg... |
DB00757 | DB01136 | 1,166 | 772 | [
"DDInter581",
"DDInter305"
] | Dolasetron | Carvedilol | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Major | 2 | [
[
[
1166,
25,
772
]
],
[
[
1166,
25,
371
],
[
371,
1,
772
]
],
[
[
1166,
6,
12523
],
[
12523,
45,
772
]
],
[
[
1166,
21,
28997
],
[
28997,... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carvedilol"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Propafenone"
],
[
"Propafenone",
"{u}... | Dolasetron may lead to a major life threatening interaction when taken with Propafenone and Propafenone (Compound) resembles Carvedilol (Compound)
Dolasetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Carvedilol (Compound)
Dolasetron (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined... |
DB01100 | DB01254 | 1,568 | 1,213 | [
"DDInter1470",
"DDInter484"
] | Pimozide | Dasatinib | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1568,
25,
1213
]
],
[
[
1568,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1568,
7,
2023
],
[
2023,
46,
1213
]
],
[
[
1568,
18,
7335
],
[
7335... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"
... | Pimozide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Pimozide (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Dasatinib (Compound)
Pimozide (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is downregulated by Dasatinib (Compound)
Pimozide (Compound) cau... |
DB00728 | DB00762 | 1,610 | 613 | [
"DDInter1612",
"DDInter973"
] | Rocuronium | Irinotecan | Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechan... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Minor | 0 | [
[
[
1610,
23,
613
]
],
[
[
1610,
21,
28658
],
[
28658,
60,
613
]
],
[
[
1610,
1,
728
],
[
728,
62,
613
]
],
[
[
1610,
63,
544
],
[
544,
... | [
[
[
"Rocuronium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Irinotecan"
]
],
[
[
"Rocuronium",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused b... | Rocuronium (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Irinotecan (Compound)
Rocuronium (Compound) resembles Vecuronium (Compound) and Vecuronium may cause a minor interaction that can limit clinical effects when taken with Irinotecan
Rocuronium may cause a moderate interaction that... |
DB01229 | DB08908 | 973 | 713 | [
"DDInter1377",
"DDInter564"
] | Paclitaxel | Dimethyl fumarate | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
973,
24,
713
]
],
[
[
973,
24,
4
],
[
4,
24,
713
]
],
[
[
973,
63,
453
],
[
453,
24,
713
]
],
[
[
973,
24,
270
],
[
270,
63,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Paclitaxel may cause a moderate interaction that could exacerbate diseases ... |
DB00515 | DB01394 | 589 | 1,554 | [
"DDInter387",
"DDInter431"
] | Cisplatin | Colchicine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Moderate | 1 | [
[
[
589,
24,
1554
]
],
[
[
589,
6,
4973
],
[
4973,
45,
1554
]
],
[
[
589,
21,
28714
],
[
28714,
60,
1554
]
],
[
[
589,
63,
367
],
[
367,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colchicine"
]
],
[
[
"Cisplatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Cisplatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Colchicine (Compound)
Cisplatin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Colchicine (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and I... |
DB00328 | DB11793 | 831 | 738 | [
"DDInter921",
"DDInter1297"
] | Indomethacin | Niraparib | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
831,
24,
738
]
],
[
[
831,
25,
1213
],
[
1213,
24,
738
]
],
[
[
831,
24,
1033
],
[
1033,
63,
738
]
],
[
[
831,
63,
1578
],
[
1578,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Indomethacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatini... | Indomethacin may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a... |
DB00358 | DB01202 | 1,010 | 1,435 | [
"DDInter1140",
"DDInter1046"
] | Mefloquine | Levetiracetam | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Moderate | 1 | [
[
[
1010,
24,
1435
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
1435
]
],
[
[
1010,
21,
28769
],
[
28769,
60,
1435
]
],
[
[
1010,
25,
1487
],
[
1... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levetiracetam"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levetiracetam (Compound)
Mefloquine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Levetiracetam (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Hydroxychloroqui... |
DB00348 | DB09280 | 254 | 1,604 | [
"DDInter1300",
"DDInter1101"
] | Nitisinone | Lumacaftor | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
254,
24,
1604
]
],
[
[
254,
24,
1171
],
[
1171,
24,
1604
]
],
[
[
254,
63,
245
],
[
245,
24,
1604
]
],
[
[
254,
23,
307
],
[
307,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepi... |
DB00731 | DB15093 | 1,144 | 1,654 | [
"DDInter1269",
"DDInter1698"
] | Nateglinide | Somapacitan | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1144,
24,
1654
]
],
[
[
1144,
63,
168
],
[
168,
23,
1654
]
],
[
[
1144,
63,
10
],
[
10,
24,
1654
]
],
[
[
1144,
24,
433
],
[
433,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone ... |
DB11952 | DB12332 | 800 | 1,619 | [
"DDInter612",
"DDInter1626"
] | Duvelisib | Rucaparib | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
800,
24,
1619
]
],
[
[
800,
62,
222
],
[
222,
23,
1619
]
],
[
[
800,
64,
1135
],
[
1135,
23,
1619
]
],
[
[
800,
63,
259
],
[
259,
... | [
[
[
"Duvelisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Duvelisib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Duvelisib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Duvelisib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor... |
DB08893 | DB11581 | 271 | 1,456 | [
"DDInter1229",
"DDInter1926"
] | Mirabegron | Venetoclax | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
271,
25,
1456
]
],
[
[
271,
62,
86
],
[
86,
24,
1456
]
],
[
[
271,
23,
982
],
[
982,
63,
1456
]
],
[
[
271,
23,
951
],
[
951,
24... | [
[
[
"Mirabegron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Mirabegron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Miconazole"
],
[
"Miconazole",... | Mirabegron may cause a minor interaction that can limit clinical effects when taken with Miconazole and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib and Ivosidenib... |
DB00195 | DB01249 | 726 | 258 | [
"DDInter198",
"DDInter958"
] | Betaxolol (ophthalmic) | Iodixanol | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
726,
24,
258
]
],
[
[
726,
24,
497
],
[
497,
1,
258
]
],
[
[
726,
21,
28748
],
[
28748,
60,
258
]
],
[
[
726,
1,
887
],
[
887,
2... | [
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
],
[
"I... | Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol
Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Betaxolol (Compound) causes Vertigo (Side Effect) and Vertigo (Side ... |
DB11652 | DB11995 | 1,155 | 1,634 | [
"DDInter1891",
"DDInter143"
] | Tucatinib | Avatrombopag | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
1155,
24,
1634
]
],
[
[
1155,
63,
760
],
[
760,
24,
1634
]
],
[
[
1155,
25,
913
],
[
913,
24,
1634
]
],
[
[
1155,
25,
971
],
[
971,
... | [
[
[
"Tucatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Tucatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
[
... | Tucatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Tucatinib may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may caus... |
DB00705 | DB11581 | 441 | 1,456 | [
"DDInter496",
"DDInter1926"
] | Delavirdine | Venetoclax | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
441,
25,
1456
]
],
[
[
441,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
441,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
441,
23,
466
],
[
466,
... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Delavirdine may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Delavirdine may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate intera... |
DB06603 | DB09030 | 39 | 840 | [
"DDInter1387",
"DDInter1945"
] | Panobinostat | Vorapaxar | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
39,
25,
840
]
],
[
[
39,
63,
765
],
[
765,
24,
840
]
],
[
[
39,
64,
529
],
[
529,
24,
840
]
],
[
[
39,
24,
1017
],
[
1017,
63,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
],
[
"Hemin",
... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Panobinostat may lead to a major life threatening interaction when taken with Fluvoxamine and Fluvoxamine may cause a mod... |
DB00334 | DB11130 | 867 | 407 | [
"DDInter1326",
"DDInter1344"
] | Olanzapine | Opium | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
867,
24,
407
]
],
[
[
867,
24,
662
],
[
662,
24,
407
]
],
[
[
867,
63,
352
],
[
352,
24,
407
]
],
[
[
867,
1,
623
],
[
623,
24,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospiu... |
DB08871 | DB09121 | 36 | 1,328 | [
"DDInter666",
"DDInter140"
] | Eribulin | Aurothioglucose | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased si... | Moderate | 1 | [
[
[
36,
24,
1328
]
],
[
[
36,
63,
367
],
[
367,
24,
1328
]
],
[
[
36,
64,
581
],
[
581,
24,
1328
]
],
[
[
36,
25,
375
],
[
375,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aurothioglucose"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1"
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Eribulin may lead to a major life threatening interaction when taken with Infliximab and ... |
DB09039 | DB11718 | 1,670 | 927 | [
"DDInter629",
"DDInter640"
] | Eliglustat | Encorafenib | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1670,
24,
927
]
],
[
[
1670,
63,
1088
],
[
1088,
24,
927
]
],
[
[
1670,
24,
938
],
[
938,
24,
927
]
],
[
[
1670,
62,
479
],
[
479,
... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifaximin"
],
[
... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Rifaximin and Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant and Pitolis... |
DB01381 | DB06754 | 958 | 707 | [
"DDInter819",
"DDInter471"
] | Ginkgo biloba | Danaparoid | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Moderate | 1 | [
[
[
958,
24,
707
]
],
[
[
958,
63,
121
],
[
121,
24,
707
]
],
[
[
958,
63,
291
],
[
291,
25,
707
]
],
[
[
958,
24,
365
],
[
365,
64,... | [
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
]
],
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
... | Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Argatroban ... |
DB00801 | DB00877 | 1,563 | 629 | [
"DDInter850",
"DDInter1678"
] | Halazepam | Sirolimus | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1563,
24,
629
]
],
[
[
1563,
40,
1418
],
[
1418,
63,
629
]
],
[
[
1563,
24,
1311
],
[
1311,
63,
629
]
],
[
[
1563,
63,
752
],
[
752,
... | [
[
[
"Halazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Halazepam",
"{u} (Compound) resembles {v} (Compound)",
"Estazolam"
],
[
"Estazolam",
"{u} may cause a moderate int... | Halazepam (Compound) resembles Estazolam (Compound) and Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus
Halazepam may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that co... |
DB00284 | DB01001 | 1,647 | 688 | [
"DDInter11",
"DDInter1632"
] | Acarbose | Salbutamol | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1647,
24,
688
]
],
[
[
1647,
24,
874
],
[
874,
24,
688
]
],
[
[
1647,
24,
1148
],
[
1148,
63,
688
]
],
[
[
1647,
21,
28826
],
[
28826,... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isopre... |
DB00376 | DB00719 | 1,105 | 1,219 | [
"DDInter1870",
"DDInter149"
] | Trihexyphenidyl | Azatadine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1105,
24,
1219
]
],
[
[
1105,
24,
13
],
[
13,
24,
1219
]
],
[
[
1105,
24,
830
],
[
830,
1,
1219
]
],
[
[
1105,
24,
543
],
[
543,
... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Phen... |
DB00814 | DB08870 | 1,171 | 850 | [
"DDInter1143",
"DDInter228"
] | Meloxicam | Brentuximab vedotin | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1171,
24,
850
]
],
[
[
1171,
63,
267
],
[
267,
24,
850
]
],
[
[
1171,
24,
1033
],
[
1033,
63,
850
]
],
[
[
1171,
25,
1468
],
[
1468,
... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and ... |
DB00176 | DB01075 | 529 | 1,376 | [
"DDInter770",
"DDInter569"
] | Fluvoxamine | Diphenhydramine | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
529,
24,
1376
]
],
[
[
529,
24,
649
],
[
649,
63,
1376
]
],
[
[
529,
24,
11
],
[
11,
1,
1376
]
],
[
[
529,
24,
128
],
[
128,
24,... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and... |
DB01359 | DB09104 | 729 | 286 | [
"DDInter1417",
"DDInter1118"
] | Penbutolol | Magnesium hydroxide | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
729,
23,
286
]
],
[
[
729,
63,
401
],
[
401,
23,
286
]
],
[
[
729,
40,
461
],
[
461,
23,
286
]
],
[
[
729,
1,
699
],
[
699,
23,
... | [
[
[
"Penbutolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Penbutolol (Compound) resembles Timolol (Compound) and Timolol may cause a minor interaction that can... |
DB00396 | DB00731 | 989 | 1,144 | [
"DDInter1529",
"DDInter1269"
] | Progesterone | Nateglinide | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in var... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
989,
24,
1144
]
],
[
[
989,
6,
6799
],
[
6799,
45,
1144
]
],
[
[
989,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
989,
63,
1051
],
[
1051,... | [
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Progesterone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compou... | Progesterone (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Nateglinide (Compound)
Progesterone (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Aminoglut... |
DB00480 | DB10583 | 1,668 | 949 | [
"DDInter1035",
"DDInter415"
] | Lenalidomide | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1668,
24,
949
]
],
[
[
1668,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1668,
63,
58
],
[
58,
24,
949
]
],
[
[
1668,
24,
663
],
[
663,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {... | Lenalidomide may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Lenalidomide may cause a moderate interaction that could exacerbate disea... |
DB09330 | DB15982 | 985 | 1,339 | [
"DDInter1352",
"DDInter193"
] | Osimertinib | Berotralstat | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
985,
25,
1339
]
],
[
[
985,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
985,
24,
283
],
[
283,
23,
1339
]
],
[
[
985,
64,
1213
],
[
1213,
... | [
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedr... |
DB00945 | DB04865 | 1,479 | 4 | [
"DDInter20",
"DDInter1335"
] | Acetylsalicylic acid | Omacetaxine mepesuccinate | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
1479,
25,
4
]
],
[
[
1479,
6,
2900
],
[
2900,
46,
4
]
],
[
[
1479,
7,
1860
],
[
1860,
46,
4
]
],
[
[
1479,
18,
2049
],
[
2049,
5... | [
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) binds {v} (Gene)",
"NFKBIA"
],
[
"NFKBIA",
"{u} (Gene) is upreg... | Acetylsalicylic acid (Compound) binds NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Acetylsalicylic acid (Compound) upregulates STX1A (Gene) and STX1A (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Acetylsalicylic acid (Compound) downregulates MRPS16 (Gene) and MR... |
DB01197 | DB11760 | 1,603 | 119 | [
"DDInter292",
"DDInter1742"
] | Captopril | Talazoparib | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
1603,
24,
119
]
],
[
[
1603,
24,
971
],
[
971,
63,
119
]
],
[
[
1603,
25,
1456
],
[
1456,
24,
119
]
],
[
[
1603,
24,
384
],
[
384,
... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Captopril may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may cau... |
DB00747 | DB00985 | 1,442 | 1,443 | [
"DDInter1647",
"DDInter562"
] | Scopolamine | Dimenhydrinate | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Moderate | 1 | [
[
[
1442,
24,
1443
]
],
[
[
1442,
24,
1376
],
[
1376,
63,
1443
]
],
[
[
1442,
63,
357
],
[
357,
1,
1443
]
],
[
[
1442,
24,
358
],
[
358,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimenhydrinate"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dimenhydrinate
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Benza... |
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