drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00586 | DB01197 | 1,512 | 1,603 | [
"DDInter537",
"DDInter292"
] | Diclofenac | Captopril | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1512,
24,
1603
]
],
[
[
1512,
63,
610
],
[
610,
1,
1603
]
],
[
[
1512,
10,
11573
],
[
11573,
44,
1603
]
],
[
[
1512,
6,
1829
],
[
1829... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Diclofenac (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Captopril (Compound)
Diclofenac (Compound) binds AL... |
DB00494 | DB01064 | 1,533 | 1,148 | [
"DDInter646",
"DDInter987"
] | Entacapone | Isoprenaline | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1533,
24,
1148
]
],
[
[
1533,
24,
874
],
[
874,
24,
1148
]
],
[
[
1533,
21,
28717
],
[
28717,
60,
1148
]
],
[
[
1533,
25,
1629
],
[
16... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Entacapone (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Isoprenaline (Co... |
DB09049 | DB15982 | 1,135 | 1,339 | [
"DDInter1261",
"DDInter193"
] | Naloxegol | Berotralstat | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
1135,
25,
1339
]
],
[
[
1135,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
1135,
25,
283
],
[
283,
23,
1339
]
],
[
[
1135,
62,
1213
],
[
1213... | [
[
[
"Naloxegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Naloxegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Naloxegol may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a ... |
DB00331 | DB00465 | 1,645 | 886 | [
"DDInter1164",
"DDInter1010"
] | Metformin | Ketorolac | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Moderate | 1 | [
[
[
1645,
24,
886
]
],
[
[
1645,
24,
24
],
[
24,
40,
886
]
],
[
[
1645,
7,
7273
],
[
7273,
46,
886
]
],
[
[
1645,
21,
28936
],
[
28936,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
],
[
"... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin (Compound) resembles Ketorolac (Compound)
Metformin (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Ketorolac (Compound)
Metformin (Compound) causes Hyperhidrosis (Side Effect) and ... |
DB00047 | DB00938 | 176 | 455 | [
"DDInter932",
"DDInter1635"
] | Insulin glargine | Salmeterol | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
176,
24,
455
]
],
[
[
176,
24,
1523
],
[
1523,
25,
455
]
],
[
[
176,
24,
688
],
[
688,
63,
455
]
],
[
[
176,
24,
167
],
[
167,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may lead to a major life threatening interaction when taken with Salmeterol
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol ... |
DB00197 | DB06016 | 1,324 | 1,508 | [
"DDInter1881",
"DDInter300"
] | Troglitazone | Cariprazine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1324,
24,
1508
]
],
[
[
1324,
24,
1593
],
[
1593,
63,
1508
]
],
[
[
1324,
63,
176
],
[
176,
24,
1508
]
],
[
[
1324,
24,
1213
],
[
1213... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine... |
DB09043 | DB09082 | 135 | 659 | [
"DDInter36",
"DDInter1934"
] | Albiglutide | Vilanterol | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
135,
24,
659
]
],
[
[
135,
63,
1220
],
[
1220,
23,
659
]
],
[
[
135,
24,
1296
],
[
1296,
63,
659
]
],
[
[
135,
63,
323
],
[
323,
... | [
[
[
"Albiglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Albiglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin deglude... |
DB00710 | DB08938 | 1,199 | 1,384 | [
"DDInter897",
"DDInter1112"
] | Ibandronate | Magaldrate | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1199,
24,
1384
]
],
[
[
1199,
24,
428
],
[
428,
63,
1384
]
],
[
[
1199,
24,
1596
],
[
1596,
24,
1384
]
],
[
[
1199,
40,
1485
],
[
1485... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
],
... | Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Iron an... |
DB06704 | DB08826 | 247 | 1,292 | [
"DDInter952",
"DDInter489"
] | Iobenguane (I-131) | Deferiprone | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
247,
25,
1292
]
],
[
[
247,
21,
28762
],
[
28762,
60,
1292
]
],
[
[
247,
63,
563
],
[
563,
25,
1292
]
],
[
[
247,
64,
453
],
[
453,
... | [
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Iobenguane",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compo... | Iobenguane may lead to a major life threatening interaction when taken with Deferiprone
Iobenguane (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Deferiprone (Compound)
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovi... |
DB00641 | DB09054 | 467 | 384 | [
"DDInter1675",
"DDInter905"
] | Simvastatin | Idelalisib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
467,
25,
384
]
],
[
[
467,
24,
1627
],
[
1627,
62,
384
]
],
[
[
467,
24,
555
],
[
555,
23,
384
]
],
[
[
467,
24,
72
],
[
72,
24,... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
"Cannabi... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netu... |
DB00277 | DB00930 | 1,031 | 166 | [
"DDInter1791",
"DDInter432"
] | Theophylline | Colesevelam | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | Moderate | 1 | [
[
[
1031,
24,
166
]
],
[
[
1031,
1,
746
],
[
746,
24,
166
]
],
[
[
1031,
24,
1152
],
[
1152,
24,
166
]
],
[
[
1031,
24,
617
],
[
617,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colesevelam"
]
],
[
[
"Theophylline",
"{u} (Compound) resembles {v} (Compound)",
"Dyphylline"
],
[
"Dyphylline",
"{u} may cause a mo... | Theophylline (Compound) resembles Dyphylline (Compound) and Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine may cause a moderate interaction t... |
DB00704 | DB14730 | 267 | 1,412 | [
"DDInter1263",
"DDInter264"
] | Naltrexone | Calaspargase pegol | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
267,
24,
1412
]
],
[
[
267,
24,
250
],
[
250,
24,
1412
]
],
[
[
267,
63,
883
],
[
883,
24,
1412
]
],
[
[
267,
63,
1101
],
[
1101,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib... |
DB00863 | DB00939 | 1,194 | 1,338 | [
"DDInter1568",
"DDInter1135"
] | Ranitidine | Meclofenamic acid | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Minor | 0 | [
[
[
1194,
23,
1338
]
],
[
[
1194,
21,
28900
],
[
28900,
60,
1338
]
],
[
[
1194,
40,
1127
],
[
1127,
23,
1338
]
],
[
[
1194,
24,
959
],
[
9... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Ranitidine",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side ... | Ranitidine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Meclofenamic acid (Compound)
Ranitidine (Compound) resembles Nizatidine (Compound) and Nizatidine may cause a minor interaction that can limit clinical effects when taken with Meclofenamic acid
Ranitidine may cause a... |
DB08901 | DB14975 | 1,468 | 988 | [
"DDInter1492",
"DDInter1949"
] | Ponatinib | Voxelotor | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
1468,
24,
988
]
],
[
[
1468,
63,
222
],
[
222,
23,
988
]
],
[
[
1468,
63,
629
],
[
629,
24,
988
]
],
[
[
1468,
64,
126
],
[
126,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus ... |
DB00197 | DB00738 | 1,324 | 485 | [
"DDInter1881",
"DDInter1420"
] | Troglitazone | Pentamidine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
1324,
24,
485
]
],
[
[
1324,
24,
971
],
[
971,
63,
485
]
],
[
[
1324,
23,
1612
],
[
1612,
63,
485
]
],
[
[
1324,
24,
867
],
[
867,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Fostemsavir an... |
DB00222 | DB00586 | 245 | 1,512 | [
"DDInter825",
"DDInter537"
] | Glimepiride | Diclofenac | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
245,
24,
1512
]
],
[
[
245,
24,
1020
],
[
1020,
1,
1512
]
],
[
[
245,
24,
1263
],
[
1263,
63,
1512
]
],
[
[
245,
6,
6017
],
[
6017,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Diclofenac (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac may cause a moderate interaction that could e... |
DB01238 | DB06589 | 673 | 1,250 | [
"DDInter118",
"DDInter1400"
] | Aripiprazole | Pazopanib | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
673,
24,
1250
]
],
[
[
673,
6,
4973
],
[
4973,
45,
1250
]
],
[
[
673,
21,
29264
],
[
29264,
60,
1250
]
],
[
[
673,
62,
112
],
[
112,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Aripiprazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Aripiprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pazopanib (Compound)
Aripiprazole (Compound) causes Rhinorrhoea (Side Effect) and Rhinorrhoea (Side Effect) is caused by Pazopanib (Compound)
Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB00344 | DB12141 | 1,302 | 971 | [
"DDInter1543",
"DDInter817"
] | Protriptyline | Gilteritinib | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1302,
24,
971
]
],
[
[
1302,
23,
112
],
[
112,
23,
971
]
],
[
[
1302,
24,
485
],
[
485,
24,
971
]
],
[
[
1302,
24,
823
],
[
823,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Protriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],... | Protriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine... |
DB00382 | DB11730 | 62 | 351 | [
"DDInter1734",
"DDInter1588"
] | Tacrine | Ribociclib | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
62,
24,
351
]
],
[
[
62,
24,
112
],
[
112,
23,
351
]
],
[
[
62,
24,
372
],
[
372,
24,
351
]
],
[
[
62,
63,
912
],
[
912,
24,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofara... |
DB09082 | DB13179 | 659 | 68 | [
"DDInter1934",
"DDInter1882"
] | Vilanterol | Troleandomycin | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
659,
24,
68
]
],
[
[
659,
63,
1374
],
[
1374,
23,
68
]
],
[
[
659,
62,
251
],
[
251,
24,
68
]
],
[
[
659,
63,
1151
],
[
1151,
24... | [
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Vilanterol may cause a minor interaction that can limit clinical effects when taken with Betamethasone and B... |
DB00295 | DB01221 | 475 | 1,190 | [
"DDInter1244",
"DDInter1007"
] | Morphine | Ketamine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
475,
24,
1190
]
],
[
[
475,
6,
8374
],
[
8374,
45,
1190
]
],
[
[
475,
21,
28642
],
[
28642,
60,
1190
]
],
[
[
475,
24,
649
],
[
649,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Morphine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketamine (Compound)
Morphine (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Ketamine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a... |
DB00595 | DB09407 | 1,545 | 853 | [
"DDInter1374",
"DDInter1114"
] | Oxytetracycline | Magnesium chloride | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
1545,
24,
853
]
],
[
[
1545,
40,
964
],
[
964,
24,
853
]
],
[
[
1545,
24,
544
],
[
544,
24,
853
]
],
[
[
1545,
24,
460
],
[
460,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Oxytetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Doxycycline"
],
[
"Doxycycline",
"{u}... | Oxytetracycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause... |
DB01083 | DB08882 | 1,142 | 1,281 | [
"DDInter1348",
"DDInter1070"
] | Orlistat | Linagliptin | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1142,
24,
1281
]
],
[
[
1142,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1142,
5,
11640
],
[
11640,
44,
1281
]
],
[
[
1142,
6,
8374
],
[
837... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Orlistat (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Linagliptin (Compound)
Orlistat (Compound) bin... |
DB00280 | DB12130 | 494 | 1,017 | [
"DDInter575",
"DDInter1094"
] | Disopyramide | Lorlatinib | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
494,
24,
1017
]
],
[
[
494,
24,
608
],
[
608,
23,
1017
]
],
[
[
494,
24,
590
],
[
590,
24,
1017
]
],
[
[
494,
25,
1491
],
[
1491,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Ace... |
DB00274 | DB00798 | 277 | 1,132 | [
"DDInter320",
"DDInter815"
] | Cefmetazole | Gentamicin | A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
277,
24,
1132
]
],
[
[
277,
24,
361
],
[
361,
63,
1132
]
],
[
[
277,
1,
1402
],
[
1402,
63,
1132
]
],
[
[
277,
24,
416
],
[
416,
... | [
[
[
"Cefmetazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Cefmetazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
],
[
... | Cefmetazole may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Cefmetazole (Compound) resembles Cefotetan (Compound) and Cefotetan may cause a moderate interaction that could exa... |
DB08826 | DB11110 | 1,292 | 603 | [
"DDInter489",
"DDInter1115"
] | Deferiprone | Magnesium citrate | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1292,
24,
603
]
],
[
[
1292,
64,
57
],
[
57,
24,
603
]
],
[
[
1292,
63,
544
],
[
544,
24,
603
]
],
[
[
1292,
25,
36
],
[
36,
24,... | [
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Deferiprone may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfa... |
DB00006 | DB01381 | 942 | 958 | [
"DDInter217",
"DDInter819"
] | Bivalirudin | Ginkgo biloba | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
942,
24,
958
]
],
[
[
942,
24,
1347
],
[
1347,
24,
958
]
],
[
[
942,
25,
126
],
[
126,
24,
958
]
],
[
[
942,
25,
792
],
[
792,
6... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Bivalirudin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cau... |
DB06792 | DB14491 | 1,606 | 428 | [
"DDInter1023",
"DDInter725"
] | Lanthanum carbonate | Ferrous fumarate | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1606,
24,
428
]
],
[
[
1606,
63,
1096
],
[
1096,
23,
428
]
],
[
[
1606,
63,
1008
],
[
1008,
24,
428
]
],
[
[
1606,
24,
320
],
[
320,
... | [
[
[
"Lanthanum carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Lanthanum carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Myc... | Lanthanum carbonate may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Lanthanum carbonate may cause a moderate interaction that could exacerbate diseases w... |
DB00451 | DB01124 | 542 | 1,411 | [
"DDInter1064",
"DDInter1828"
] | Levothyroxine | Tolbutamide | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
542,
24,
1411
]
],
[
[
542,
24,
959
],
[
959,
40,
1411
]
],
[
[
542,
63,
245
],
[
245,
40,
1411
]
],
[
[
542,
6,
3486
],
[
3486,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Co... |
DB01185 | DB06404 | 155 | 1,514 | [
"DDInter759",
"DDInter869"
] | Fluoxymesterone | Human C1-esterase inhibitor | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Moderate | 1 | [
[
[
155,
24,
1514
]
],
[
[
155,
40,
1581
],
[
1581,
24,
1514
]
],
[
[
155,
1,
984
],
[
984,
24,
1514
]
],
[
[
155,
1,
1546
],
[
1546,
... | [
[
[
"Fluoxymesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human C1-esterase inhibitor"
]
],
[
[
"Fluoxymesterone",
"{u} (Compound) resembles {v} (Compound)",
"Testolactone"
],
[
"Testolactone",... | Fluoxymesterone (Compound) resembles Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Fluoxymesterone (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases wh... |
DB00564 | DB01142 | 1,236 | 1,264 | [
"DDInter293",
"DDInter593"
] | Carbamazepine | Doxepin | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1236,
24,
1264
]
],
[
[
1236,
40,
508
],
[
508,
24,
1264
]
],
[
[
1236,
24,
401
],
[
401,
24,
1264
]
],
[
[
1236,
63,
1594
],
[
1594,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Carbamazepine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause a modera... | Carbamazepine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that ... |
DB00761 | DB00881 | 1,621 | 954 | [
"DDInter1497",
"DDInter1554"
] | Potassium chloride | Quinapril | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Major | 2 | [
[
[
1621,
25,
954
]
],
[
[
1621,
64,
1638
],
[
1638,
1,
954
]
],
[
[
1621,
25,
664
],
[
664,
1,
954
]
],
[
[
1621,
21,
28649
],
[
28649,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinapril"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trandolapril"
],
[
"Trandola... | Potassium chloride may lead to a major life threatening interaction when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Perindopril and Perindopril (Compound) resembles Quinapril (Compound)
Potassium ... |
DB00982 | DB09098 | 1,517 | 98 | [
"DDInter991",
"DDInter1700"
] | Isotretinoin | Somatrem | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1517,
24,
98
]
],
[
[
1517,
63,
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],
[
1573,
24,
98
]
],
[
[
1517,
24,
1375
],
[
1375,
63,
98
]
],
[
[
1517,
24,
868
],
[
868,
... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefam... |
DB01001 | DB01124 | 688 | 1,411 | [
"DDInter1632",
"DDInter1828"
] | Salbutamol | Tolbutamide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
688,
24,
1411
]
],
[
[
688,
24,
959
],
[
959,
40,
1411
]
],
[
[
688,
63,
245
],
[
245,
40,
1411
]
],
[
[
688,
21,
29222
],
[
29222,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound... |
DB01136 | DB09065 | 772 | 760 | [
"DDInter305",
"DDInter424"
] | Carvedilol | Cobicistat | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
772,
24,
760
]
],
[
[
772,
24,
1374
],
[
1374,
23,
760
]
],
[
[
772,
24,
868
],
[
868,
24,
760
]
],
[
[
772,
24,
1033
],
[
1033,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemur... |
DB00777 | DB11186 | 146 | 1,609 | [
"DDInter1537",
"DDInter1427"
] | Propiomazine | Pentoxyverine | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
146,
24,
1609
]
],
[
[
146,
40,
508
],
[
508,
24,
1609
]
],
[
[
146,
1,
104
],
[
104,
24,
1609
]
],
[
[
146,
63,
506
],
[
506,
2... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Propiomazine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause a mo... | Propiomazine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Propiomazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pe... |
DB01149 | DB06228 | 851 | 792 | [
"DDInter1274",
"DDInter1609"
] | Nefazodone | Rivaroxaban | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
851,
24,
792
]
],
[
[
851,
6,
4973
],
[
4973,
45,
792
]
],
[
[
851,
21,
28703
],
[
28703,
60,
792
]
],
[
[
851,
23,
466
],
[
466,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Nefazodone (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Nefazodone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolu... |
DB00515 | DB00549 | 589 | 522 | [
"DDInter387",
"DDInter1955"
] | Cisplatin | Zafirlukast | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
589,
24,
522
]
],
[
[
589,
6,
17404
],
[
17404,
45,
522
]
],
[
[
589,
21,
28784
],
[
28784,
60,
522
]
],
[
[
589,
63,
168
],
[
168,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Cisplatin",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Cisplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Zafirlukast (Compound)
Cisplatin (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Zafirlukast (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezom... |
DB00213 | DB00476 | 837 | 109 | [
"DDInter1388",
"DDInter608"
] | Pantoprazole | Duloxetine | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Minor | 0 | [
[
[
837,
23,
109
]
],
[
[
837,
6,
7950
],
[
7950,
45,
109
]
],
[
[
837,
21,
28864
],
[
28864,
60,
109
]
],
[
[
837,
1,
660
],
[
660,
... | [
[
[
"Pantoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Duloxetine"
]
],
[
[
"Pantoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Pantoprazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Duloxetine (Compound)
Pantoprazole (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Duloxetine (Compound)
Pantoprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole may cause a... |
DB00434 | DB01563 | 13 | 680 | [
"DDInter459",
"DDInter349"
] | Cyproheptadine | Chloral hydrate | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. | Moderate | 1 | [
[
[
13,
24,
680
]
],
[
[
13,
24,
272
],
[
272,
24,
680
]
],
[
[
13,
24,
1609
],
[
1609,
63,
680
]
],
[
[
13,
63,
1242
],
[
1242,
24,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloral hydrate"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorphenirami... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00831 | DB01177 | 1,178 | 77 | [
"DDInter1866",
"DDInter904"
] | Trifluoperazine | Idarubicin | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1178,
24,
77
]
],
[
[
1178,
6,
3588
],
[
3588,
46,
77
]
],
[
[
1178,
7,
18228
],
[
18228,
46,
77
]
],
[
[
1178,
18,
6538
],
[
6538,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) binds {v} (Gene)",
"TNNC1"
],
[
"TNNC1",
"{u} (Gene) is upregulated by {v... | Trifluoperazine (Compound) binds TNNC1 (Gene) and TNNC1 (Gene) is upregulated by Idarubicin (Compound)
Trifluoperazine (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is upregulated by Idarubicin (Compound)
Trifluoperazine (Compound) downregulates PSMB10 (Gene) and PSMB10 (Gene) is upregulated by Idarubicin (Compo... |
DB08871 | DB14783 | 36 | 287 | [
"DDInter666",
"DDInter574"
] | Eribulin | Diroximel fumarate | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
36,
24,
287
]
],
[
[
36,
24,
384
],
[
384,
24,
287
]
],
[
[
36,
63,
599
],
[
599,
24,
287
]
],
[
[
36,
64,
478
],
[
478,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and A... |
DB00851 | DB01610 | 611 | 248 | [
"DDInter463",
"DDInter1912"
] | Dacarbazine | Valganciclovir | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
611,
24,
248
]
],
[
[
611,
24,
563
],
[
563,
1,
248
]
],
[
[
611,
63,
1238
],
[
1238,
24,
248
]
],
[
[
611,
25,
507
],
[
507,
63... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Pentostatin and Pentostatin may cause a moderate interaction ... |
DB00601 | DB09080 | 453 | 144 | [
"DDInter1073",
"DDInter1331"
] | Linezolid | Olodaterol | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
453,
24,
144
]
],
[
[
453,
25,
1011
],
[
1011,
24,
144
]
],
[
[
453,
24,
31
],
[
31,
24,
144
]
],
[
[
453,
64,
1048
],
[
1048,
2... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolimod",... | Linezolid may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline and Xylometazoline may ... |
DB01236 | DB12245 | 679 | 823 | [
"DDInter1664",
"DDInter1863"
] | Sevoflurane | Triclabendazole | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
679,
24,
823
]
],
[
[
679,
62,
112
],
[
112,
23,
823
]
],
[
[
679,
63,
1010
],
[
1010,
24,
823
]
],
[
[
679,
24,
28
],
[
28,
24,... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Sevoflurane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB01225 | DB08875 | 500 | 1,618 | [
"DDInter645",
"DDInter262"
] | Enoxaparin | Cabozantinib | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
500,
25,
1618
]
],
[
[
500,
24,
41
],
[
41,
63,
1618
]
],
[
[
500,
25,
283
],
[
283,
63,
1618
]
],
[
[
500,
63,
222
],
[
222,
24... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"Lev... | Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Enoxaparin may lead to a major life threatening interaction when taken with Fedratinib and Fedratini... |
DB00349 | DB08900 | 902 | 1,162 | [
"DDInter401",
"DDInter1753"
] | Clobazam | Teduglutide | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine). The significance of this substitution is that te... | Moderate | 1 | [
[
[
902,
24,
1162
]
],
[
[
902,
40,
1119
],
[
1119,
24,
1162
]
],
[
[
902,
40,
1119
],
[
1119,
40,
1382
],
[
1382,
24,
1162
]
],
[
[
902,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teduglutide"
]
],
[
[
"Clobazam",
"{u} (Compound) resembles {v} (Compound)",
"Chlordiazepoxide"
],
[
"Chlordiazepoxide",
"{u} may cause ... | Clobazam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Teduglutide
Clobazam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide (Compound) resembles Midazolam (Compound) and Midazolam may cause a mo... |
DB00312 | DB08899 | 1,023 | 129 | [
"DDInter1423",
"DDInter649"
] | Pentobarbital | Enzalutamide | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1023,
24,
129
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1023,
21,
28921
],
[
28921,
60,
129
]
],
[
[
1023,
24,
112
],
[
112,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Pentobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Pentobarbital (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Enzalutamide (Compound)
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Metron... |
DB06663 | DB11853 | 1,154 | 230 | [
"DDInter1398",
"DDInter1577"
] | Pasireotide | Relugolix | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Major | 2 | [
[
[
1154,
25,
230
]
],
[
[
1154,
25,
129
],
[
129,
23,
230
]
],
[
[
1154,
62,
112
],
[
112,
23,
230
]
],
[
[
1154,
63,
480
],
[
480,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Relugolix"
]
],
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
"... | Pasireotide may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Pasireotide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may... |
DB00342 | DB00370 | 1,181 | 1,251 | [
"DDInter1770",
"DDInter1230"
] | Terfenadine | Mirtazapine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Moderate | 1 | [
[
[
1181,
24,
1251
]
],
[
[
1181,
23,
112
],
[
112,
62,
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],
[
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1181,
24,
392
],
[
392,
63,
1251
]
],
[
[
1181,
25,
609
],
[
609,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Mirtazapine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and La... |
DB00242 | DB00812 | 1,064 | 998 | [
"DDInter392",
"DDInter1451"
] | Cladribine | Phenylbutazone | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Major | 2 | [
[
[
1064,
25,
998
]
],
[
[
1064,
24,
362
],
[
362,
1,
998
]
],
[
[
1064,
7,
7720
],
[
7720,
45,
998
]
],
[
[
1064,
64,
168
],
[
168,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
"Phenyto... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenylbutazone (Compound)
Cladribine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Phenylbutazone (Compound)
Cladribine may lead to a major life threatening interact... |
DB00515 | DB01044 | 589 | 246 | [
"DDInter387",
"DDInter809"
] | Cisplatin | Gatifloxacin | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Minor | 0 | [
[
[
589,
23,
246
]
],
[
[
589,
23,
739
],
[
739,
1,
246
]
],
[
[
589,
62,
1176
],
[
1176,
1,
246
]
],
[
[
589,
23,
945
],
[
945,
40,... | [
[
[
"Cisplatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Cisplatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Cisplatin may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Comp... |
DB00342 | DB11978 | 1,181 | 124 | [
"DDInter1770",
"DDInter822"
] | Terfenadine | Glasdegib | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1181,
24,
124
]
],
[
[
1181,
23,
1247
],
[
1247,
23,
124
]
],
[
[
1181,
24,
327
],
[
327,
24,
124
]
],
[
[
1181,
24,
1032
],
[
1032,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Abametapir a... |
DB01059 | DB06663 | 956 | 1,154 | [
"DDInter1313",
"DDInter1398"
] | Norfloxacin | Pasireotide | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
956,
25,
1154
]
],
[
[
956,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
956,
62,
112
],
[
112,
23,
1154
]
],
[
[
956,
24,
1385
],
[
1385,
... | [
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Norfloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused... | Norfloxacin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when tak... |
DB00404 | DB08904 | 523 | 375 | [
"DDInter54",
"DDInter342"
] | Alprazolam | Certolizumab pegol | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
523,
24,
375
]
],
[
[
523,
24,
1593
],
[
1593,
24,
375
]
],
[
[
523,
63,
608
],
[
608,
24,
375
]
],
[
[
523,
1,
902
],
[
902,
24... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and... |
DB00494 | DB00514 | 1,533 | 506 | [
"DDInter646",
"DDInter527"
] | Entacapone | Dextromethorphan | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
1533,
24,
506
]
],
[
[
1533,
21,
28810
],
[
28810,
60,
506
]
],
[
[
1533,
63,
13
],
[
13,
24,
506
]
],
[
[
1533,
24,
717
],
[
717,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Entacapone",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
... | Entacapone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Dextromethorphan (Compound)
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exace... |
DB00059 | DB06081 | 1,560 | 1,046 | [
"DDInter1404",
"DDInter286"
] | Pegaspargase | Caplacizumab | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Moderate | 1 | [
[
[
1560,
24,
1046
]
],
[
[
1560,
24,
1171
],
[
1171,
24,
1046
]
],
[
[
1560,
24,
1496
],
[
1496,
63,
1046
]
],
[
[
1560,
24,
1479
],
[
14... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caplacizumab"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Ni... |
DB00619 | DB04868 | 1,419 | 478 | [
"DDInter909",
"DDInter1293"
] | Imatinib | Nilotinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1419,
35,
478
]
],
[
[
1419,
35,
1468
],
[
1468,
63,
478
]
],
[
[
1419,
5,
11555
],
[
11555,
44,
478
]
],
[
[
1419,
6,
15724
],
[
1572... | [
[
[
"Imatinib",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Imatinib",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that... | Imatinib (Compound) resembles Nilotinib (Compound) and
Imatinib (Compound) resembles Ponatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Imatini... |
DB00059 | DB15066 | 1,560 | 445 | [
"DDInter1404",
"DDInter821"
] | Pegaspargase | Givosiran | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Moderate | 1 | [
[
[
1560,
24,
445
]
],
[
[
1560,
24,
1555
],
[
1555,
24,
445
]
],
[
[
1560,
25,
1377
],
[
1377,
25,
445
]
],
[
[
1560,
24,
187
],
[
187,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Givosiran"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Pegaspargase may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may... |
DB01131 | DB06697 | 1,243 | 436 | [
"DDInter1531",
"DDInter121"
] | Proguanil | Artemether | Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Moderate | 1 | [
[
[
1243,
24,
436
]
],
[
[
1243,
5,
11571
],
[
11571,
44,
436
]
],
[
[
1243,
6,
12523
],
[
12523,
45,
436
]
],
[
[
1243,
24,
283
],
[
283,... | [
[
[
"Proguanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Artemether"
]
],
[
[
"Proguanil",
"{u} (Compound) treats {v} (Disease)",
"malaria"
],
[
"malaria",
"{u} (Disease) is treated by {v} (Co... | Proguanil (Compound) treats malaria (Disease) and malaria (Disease) is treated by Artemether (Compound)
Proguanil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Artemether (Compound)
Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cau... |
DB00250 | DB01232 | 10 | 1,327 | [
"DDInter475",
"DDInter1640"
] | Dapsone | Saquinavir | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
10,
25,
1327
]
],
[
[
10,
63,
798
],
[
798,
40,
1327
]
],
[
[
10,
6,
10215
],
[
10215,
45,
1327
]
],
[
[
10,
21,
28900
],
[
28900,
... | [
[
[
"Dapsone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",
... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Dapsone (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Saquinavir (Compound)
Dapsone (Compound) causes Abdominal pain (Side Effect) and Abdominal p... |
DB00193 | DB00662 | 534 | 717 | [
"DDInter1841",
"DDInter1873"
] | Tramadol | Trimethobenzamide | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
534,
24,
717
]
],
[
[
534,
25,
1425
],
[
1425,
40,
717
]
],
[
[
534,
21,
29648
],
[
29648,
60,
717
]
],
[
[
534,
24,
1594
],
[
1594,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
],
[
"Cisaprid... | Tramadol may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Trimethobenzamide (Compound)
Tramadol (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Tramadol may cause a moderate interaction... |
DB01024 | DB01051 | 1,096 | 1,153 | [
"DDInter1252",
"DDInter1317"
] | Mycophenolic acid | Novobiocin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Novobiocin is an antibiotic compound derived from _Streptomyces niveus_. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin,... | Moderate | 1 | [
[
[
1096,
24,
1153
]
],
[
[
1096,
7,
4634
],
[
4634,
46,
1153
]
],
[
[
1096,
18,
4675
],
[
4675,
57,
1153
]
],
[
[
1096,
7,
4634
],
[
4634... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Novobiocin"
]
],
[
[
"Mycophenolic acid",
"{u} (Compound) upregulates {v} (Gene)",
"FOXO4"
],
[
"FOXO4",
"{u} (Gene) is upregul... | Mycophenolic acid (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Novobiocin (Compound)
Mycophenolic acid (Compound) downregulates PLOD3 (Gene) and PLOD3 (Gene) is downregulated by Novobiocin (Compound)
Mycophenolic acid (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) regulates PTGS2 (Gene) ... |
DB00973 | DB06210 | 1,149 | 72 | [
"DDInter707",
"DDInter631"
] | Ezetimibe | Eltrombopag | Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it was being localized within enterocytes of the intestinal vill... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
1149,
24,
72
]
],
[
[
1149,
6,
15705
],
[
15705,
45,
72
]
],
[
[
1149,
63,
467
],
[
467,
24,
72
]
],
[
[
1149,
24,
484
],
[
484,
... | [
[
[
"Ezetimibe",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Ezetimibe",
"{u} (Compound) binds {v} (Gene)",
"UGT1A1"
],
[
"UGT1A1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ezetimibe (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Eltrombopag (Compound)
Ezetimibe may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Ezetimibe may ca... |
DB00834 | DB01254 | 932 | 1,213 | [
"DDInter1215",
"DDInter484"
] | Mifepristone | Dasatinib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
932,
25,
1213
]
],
[
[
932,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
932,
7,
3466
],
[
3466,
46,
1213
]
],
[
[
932,
18,
4071
],
[
4071,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasati... | Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Mifepristone (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Dasatinib (Compound)
Mifepristone (Compound) downregulates PNP (Gene) and PNP (Gene) is downregulated by Dasatinib (Compound)
Mifepristone (Com... |
DB01244 | DB12332 | 762 | 1,619 | [
"DDInter192",
"DDInter1626"
] | Bepridil | Rucaparib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
762,
25,
1619
]
],
[
[
762,
62,
112
],
[
112,
23,
1619
]
],
[
[
762,
23,
1135
],
[
1135,
23,
1619
]
],
[
[
762,
25,
1662
],
[
1662,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Bepridil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazole"... | Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Bepridil may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol ma... |
DB00633 | DB04837 | 614 | 649 | [
"DDInter520",
"DDInter407"
] | Dexmedetomidine | Clofedanol | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
614,
24,
649
]
],
[
[
614,
24,
1376
],
[
1376,
24,
649
]
],
[
[
614,
24,
832
],
[
832,
40,
649
]
],
[
[
614,
63,
701
],
[
701,
2... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00619 | DB05351 | 1,419 | 101 | [
"DDInter909",
"DDInter519"
] | Imatinib | Dexlansoprazole | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
1419,
24,
101
]
],
[
[
1419,
63,
109
],
[
109,
23,
101
]
],
[
[
1419,
24,
263
],
[
263,
62,
101
]
],
[
[
1419,
35,
1468
],
[
1468,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Axitinib and Axitinib ... |
DB00912 | DB09128 | 473 | 1,241 | [
"DDInter1581",
"DDInter231"
] | Repaglinide | Brexpiprazole | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
473,
24,
1241
]
],
[
[
473,
24,
549
],
[
549,
24,
1241
]
],
[
[
473,
24,
913
],
[
913,
63,
1241
]
],
[
[
473,
63,
104
],
[
104,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Apalutamid... |
DB00004 | DB11003 | 669 | 748 | [
"DDInter499",
"DDInter100"
] | Denileukin diftitox | Anthrax vaccine | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
669,
24,
748
]
],
[
[
669,
25,
676
],
[
676,
63,
748
]
],
[
[
669,
24,
1683
],
[
1683,
24,
748
]
],
[
[
669,
25,
1057
],
[
1057,
... | [
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]... | Denileukin diftitox may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Ustekinum... |
DB08868 | DB10276 | 1,011 | 1,624 | [
"DDInter737",
"DDInter1623"
] | Fingolimod | Rotavirus vaccine | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1011,
25,
1624
]
],
[
[
1011,
64,
617
],
[
617,
24,
1624
]
],
[
[
1011,
64,
552
],
[
552,
25,
1624
]
],
[
[
1011,
25,
1583
],
[
1583,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
],
[
"Budesonide",
... | Fingolimod may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Fingolimod may lead to a major life threatening interaction when taken with Carmustine and Carmustine may lead to a majo... |
DB00685 | DB13928 | 1,299 | 1,385 | [
"DDInter1887",
"DDInter1660"
] | Trovafloxacin | Semaglutide | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1299,
24,
1385
]
],
[
[
1299,
25,
891
],
[
891,
24,
1385
]
],
[
[
1299,
1,
872
],
[
872,
24,
1385
]
],
[
[
1299,
63,
305
],
[
305,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisolone"
],
[
"P... | Trovafloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Trovafloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could... |
DB00872 | DB06603 | 1,080 | 39 | [
"DDInter438",
"DDInter1387"
] | Conivaptan | Panobinostat | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1080,
25,
39
]
],
[
[
1080,
25,
455
],
[
455,
24,
39
]
],
[
[
1080,
25,
578
],
[
578,
63,
39
]
],
[
[
1080,
24,
850
],
[
850,
63... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Salmeterol"
],
[
"Salmeterol",
"{u}... | Conivaptan may lead to a major life threatening interaction when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Conivaptan may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a moderate in... |
DB00496 | DB00514 | 194 | 506 | [
"DDInter480",
"DDInter527"
] | Darifenacin | Dextromethorphan | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
194,
24,
506
]
],
[
[
194,
6,
8374
],
[
8374,
45,
506
]
],
[
[
194,
21,
28810
],
[
28810,
60,
506
]
],
[
[
194,
24,
741
],
[
741,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Darifenacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Darifenacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Darifenacin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Dextromethorphan (Compound)
Darifenacin may cause a moderate interaction that could exacerbate disea... |
DB00357 | DB11689 | 1,051 | 321 | [
"DDInter71",
"DDInter1659"
] | Aminoglutethimide | Selumetinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
[
1051,
24,
321
]
],
[
[
1051,
24,
392
],
[
392,
24,
321
]
],
[
[
1051,
24,
1297
],
[
1297,
63,
321
]
],
[
[
1051,
62,
1101
],
[
1101,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Osilodro... |
DB08868 | DB13139 | 1,011 | 1,032 | [
"DDInter737",
"DDInter1063"
] | Fingolimod | Levosalbutamol | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1011,
24,
1032
]
],
[
[
1011,
64,
1573
],
[
1573,
23,
1032
]
],
[
[
1011,
25,
1618
],
[
1618,
24,
1032
]
],
[
[
1011,
64,
594
],
[
594... | [
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Predni... | Fingolimod may lead to a major life threatening interaction when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Fingolimod may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderat... |
DB00994 | DB01357 | 361 | 890 | [
"DDInter1277",
"DDInter1160"
] | Neomycin | Mestranol | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
361,
24,
890
]
],
[
[
361,
63,
1438
],
[
1438,
1,
890
]
],
[
[
361,
63,
50
],
[
50,
24,
890
]
],
[
[
361,
35,
416
],
[
416,
24,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
"E... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Mestranol (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that could ... |
DB01577 | DB09241 | 1,529 | 1,629 | [
"DDInter1161",
"DDInter1186"
] | Metamfetamine | Methylene blue | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1529,
25,
1629
]
],
[
[
1529,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
1529,
24,
659
],
[
659,
24,
1629
]
],
[
[
1529,
75,
73
],
[
73,
... | [
[
[
"Metamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Vilante... |
DB01176 | DB01591 | 537 | 667 | [
"DDInter453",
"DDInter1696"
] | Cyclizine | Solifenacin | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
537,
24,
667
]
],
[
[
537,
21,
28703
],
[
28703,
60,
667
]
],
[
[
537,
40,
830
],
[
830,
63,
667
]
],
[
[
537,
40,
104
],
[
104,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Cyclizine",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused ... | Cyclizine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Solifenacin (Compound)
Cyclizine (Compound) resembles Phenindamine (Compound) and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Solifenacin
Cyclizine (Compound) resembles Methdilazin... |
DB00888 | DB08908 | 1,001 | 713 | [
"DDInter1133",
"DDInter564"
] | Mechlorethamine | Dimethyl fumarate | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1001,
24,
713
]
],
[
[
1001,
24,
4
],
[
4,
24,
713
]
],
[
[
1001,
24,
270
],
[
270,
63,
713
]
],
[
[
1001,
63,
134
],
[
134,
24,... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxin... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Mechlorethamine may cause a moderate interaction that could exacerbate... |
DB00078 | DB00081 | 1,172 | 273 | [
"DDInter898",
"DDInter1838"
] | Ibritumomab tiuxetan | Tositumomab | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Major | 2 | [
[
[
1172,
25,
273
]
],
[
[
1172,
23,
539
],
[
539,
62,
273
]
],
[
[
1172,
24,
109
],
[
109,
63,
273
]
],
[
[
1172,
63,
1184
],
[
1184,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tositumomab"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
... | Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tositumomab
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Duloxeti... |
DB01619 | DB05541 | 830 | 801 | [
"DDInter1441",
"DDInter239"
] | Phenindamine | Brivaracetam | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
830,
24,
801
]
],
[
[
830,
63,
475
],
[
475,
24,
801
]
],
[
[
830,
1,
1219
],
[
1219,
24,
801
]
],
[
[
830,
40,
104
],
[
104,
24... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam
Phenindamine (Compound) resembles Azatadine (Compound) and Azatadine may cause a moderate interaction that could... |
DB00723 | DB09043 | 1,240 | 135 | [
"DDInter1176",
"DDInter36"
] | Methoxamine | Albiglutide | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1240,
24,
135
]
],
[
[
1240,
63,
1647
],
[
1647,
23,
135
]
],
[
[
1240,
63,
176
],
[
176,
24,
135
]
],
[
[
1240,
24,
688
],
[
688,
... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Ins... |
DB09080 | DB09352 | 144 | 373 | [
"DDInter1331",
"DDInter892"
] | Olodaterol | Hydroxyamphetamine (ophthalmic) | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | 4-(2-aminopropyl)phenol is a member of amphetamines. | Moderate | 1 | [
[
[
144,
24,
373
]
],
[
[
144,
63,
480
],
[
480,
24,
373
]
],
[
[
144,
24,
659
],
[
659,
24,
373
]
],
[
[
144,
63,
480
],
[
480,
24,... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyamphetamine"
]
],
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyamphetamine
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyamphet... |
DB11943 | DB13928 | 255 | 1,385 | [
"DDInter495",
"DDInter1660"
] | Delafloxacin | Semaglutide | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
255,
24,
1385
]
],
[
[
255,
64,
891
],
[
891,
24,
1385
]
],
[
[
255,
24,
1476
],
[
1476,
24,
1385
]
],
[
[
255,
63,
417
],
[
417,
... | [
[
[
"Delafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Delafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisolone"
],
[
"Pre... | Delafloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Delafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib m... |
DB00526 | DB01166 | 1,555 | 477 | [
"DDInter1355",
"DDInter379"
] | Oxaliplatin | Cilostazol | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1555,
24,
477
]
],
[
[
1555,
6,
7950
],
[
7950,
45,
477
]
],
[
[
1555,
24,
112
],
[
112,
23,
477
]
],
[
[
1555,
23,
1247
],
[
1247,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Oxaliplatin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cilostazol (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Oxaliplatin ... |
DB00461 | DB12332 | 598 | 1,619 | [
"DDInter1254",
"DDInter1626"
] | Nabumetone | Rucaparib | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
598,
24,
1619
]
],
[
[
598,
24,
222
],
[
222,
23,
1619
]
],
[
[
598,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
598,
25,
1213
],
[
1213,
... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and ... |
DB01299 | DB08870 | 698 | 850 | [
"DDInter1722",
"DDInter228"
] | Sulfadoxine | Brentuximab vedotin | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
698,
24,
850
]
],
[
[
698,
63,
267
],
[
267,
24,
850
]
],
[
[
698,
1,
1247
],
[
1247,
24,
850
]
],
[
[
698,
24,
1254
],
[
1254,
... | [
[
[
"Sulfadoxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Sulfadoxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Sulfadoxine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Sulfadoxine (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate... |
DB00694 | DB11979 | 51 | 1,320 | [
"DDInter486",
"DDInter625"
] | Daunorubicin (liposomal) | Elagolix | Daunomycin can cause cancer according to an independent committee of scientific and health experts. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
51,
24,
1320
]
],
[
[
51,
24,
1612
],
[
1612,
23,
1320
]
],
[
[
51,
24,
1297
],
[
1297,
24,
1320
]
],
[
[
51,
63,
79
],
[
79,
24... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Elagolix
Daunorubic... |
DB01320 | DB06626 | 651 | 263 | [
"DDInter783",
"DDInter147"
] | Fosphenytoin | Axitinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
651,
25,
263
]
],
[
[
651,
64,
752
],
[
752,
23,
263
]
],
[
[
651,
63,
1194
],
[
1194,
23,
263
]
],
[
[
651,
63,
322
],
[
322,
2... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cimetidine"
],
[
"Cimetidine",
"{u}... | Fosphenytoin may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Axitinib
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause ... |
DB00081 | DB00465 | 273 | 886 | [
"DDInter1838",
"DDInter1010"
] | Tositumomab | Ketorolac | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Major | 2 | [
[
[
273,
37,
886
]
],
[
[
273,
24,
282
],
[
282,
40,
886
]
],
[
[
273,
25,
24
],
[
24,
40,
886
]
],
[
[
273,
64,
20
],
[
20,
24,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Ketorolac"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that coul... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Nepafenac and Nepafenac (Compound) resembles Ketorolac (Compound)
Tositumomab may lead to a major life threatening interac... |
DB06772 | DB08865 | 310 | 1,593 | [
"DDInter259",
"DDInter448"
] | Cabazitaxel | Crizotinib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
310,
24,
1593
]
],
[
[
310,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
310,
6,
16974
],
[
16974,
57,
1593
]
],
[
[
310,
21,
29093
],
[
29093... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Cabazitaxel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Cabazitaxel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Cabazitaxel (Compound) binds TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Crizotinib (Compound)
Cabazitaxel (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Cabazitaxel... |
DB00295 | DB00454 | 475 | 1,349 | [
"DDInter1244",
"DDInter1150"
] | Morphine | Meperidine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Major | 2 | [
[
[
475,
25,
1349
]
],
[
[
475,
24,
901
],
[
901,
1,
1349
]
],
[
[
475,
6,
7940
],
[
7940,
45,
1349
]
],
[
[
475,
54,
19161
],
[
19161,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meperidine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
[
"Milnacipran",... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Meperidine (Compound)
Morphine (Compound) binds OPRK1 (Gene) and OPRK1 (Gene) is bound by Meperidine (Compound)
Morphine (Compound) is included by Full Opioid Agonists (Pharmacologic... |
DB00106 | DB09054 | 618 | 384 | [
"DDInter4",
"DDInter905"
] | Abarelix | Idelalisib | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
618,
24,
384
]
],
[
[
618,
25,
318
],
[
318,
23,
384
]
],
[
[
618,
24,
479
],
[
479,
23,
384
]
],
[
[
618,
25,
1618
],
[
1618,
2... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalopram... | Abarelix may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a mi... |
DB11057 | DB11901 | 720 | 913 | [
"DDInter1223",
"DDInter107"
] | Mineral oil | Apalutamide | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
720,
24,
913
]
],
[
[
720,
63,
600
],
[
600,
24,
913
]
],
[
[
720,
24,
823
],
[
823,
63,
913
]
],
[
[
720,
24,
1375
],
[
1375,
6... | [
[
[
"Mineral oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Mineral oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Mineral oil may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Mineral oil may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole ... |
DB01591 | DB04843 | 667 | 1,511 | [
"DDInter1696",
"DDInter1149"
] | Solifenacin | Mepenzolate | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
667,
24,
1511
]
],
[
[
667,
63,
537
],
[
537,
24,
1511
]
],
[
[
667,
24,
1429
],
[
1429,
63,
1511
]
],
[
[
667,
6,
7992
],
[
7992,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium and Aclid... |
DB00163 | DB00987 | 1,461 | 1,224 | [
"DDInter1943",
"DDInter461"
] | Vitamin E | Cytarabine (liposomal) | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
1461,
24,
1224
]
],
[
[
1461,
24,
1426
],
[
1426,
1,
1224
]
],
[
[
1461,
24,
322
],
[
322,
24,
1224
]
],
[
[
1461,
62,
66
],
[
66,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Cytarabine (Compound)
Vitamin E may cause a moderate interaction that could exac... |
DB00364 | DB08938 | 417 | 1,384 | [
"DDInter1717",
"DDInter1112"
] | Sucralfate | Magaldrate | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
417,
24,
1384
]
],
[
[
417,
23,
1178
],
[
1178,
23,
1384
]
],
[
[
417,
62,
88
],
[
88,
23,
1384
]
],
[
[
417,
24,
1252
],
[
1252,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trifluoperazine"
],
[... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Trifluoperazine and Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Metoprolol and Me... |
DB01591 | DB08897 | 667 | 1,429 | [
"DDInter1696",
"DDInter22"
] | Solifenacin | Aclidinium | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
667,
24,
1429
]
],
[
[
667,
63,
352
],
[
352,
24,
1429
]
],
[
[
667,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
667,
6,
4304
],
[
4304,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzo... |
DB00322 | DB14711 | 141 | 779 | [
"DDInter742",
"DDInter1680"
] | Floxuridine | Smallpox (Vaccinia) Vaccine, Live | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
141,
25,
779
]
],
[
[
141,
64,
1064
],
[
1064,
25,
779
]
],
[
[
141,
25,
1377
],
[
1377,
25,
779
]
],
[
[
141,
24,
147
],
[
147,
... | [
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"... | Floxuridine may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Floxuridine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may lead to a... |
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