drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB11921 | DB12010 | 1,019 | 214 | [
"DDInter492",
"DDInter785"
] | Deflazacort | Fostamatinib | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1019,
24,
214
]
],
[
[
1019,
64,
976
],
[
976,
24,
214
]
],
[
[
1019,
63,
1428
],
[
1428,
24,
214
]
],
[
[
1019,
25,
676
],
[
676,
... | [
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Deflazacort",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofac... | Deflazacort may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may ... |
DB01009 | DB06603 | 935 | 39 | [
"DDInter1009",
"DDInter1387"
] | Ketoprofen | Panobinostat | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
935,
25,
39
]
],
[
[
935,
63,
912
],
[
912,
24,
39
]
],
[
[
935,
1,
282
],
[
282,
63,
39
]
],
[
[
935,
24,
578
],
[
578,
63,
... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
],
[
"... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Ketoprofen (Compound) resembles Nepafenac (Compound) and Nepafenac may cause a moderate intera... |
DB00377 | DB11642 | 1,494 | 938 | [
"DDInter1382",
"DDInter1480"
] | Palonosetron | Pitolisant | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1494,
24,
938
]
],
[
[
1494,
23,
112
],
[
112,
23,
938
]
],
[
[
1494,
24,
28
],
[
28,
24,
938
]
],
[
[
1494,
63,
600
],
[
600,
2... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and B... |
DB00563 | DB06718 | 663 | 1,687 | [
"DDInter1174",
"DDInter1709"
] | Methotrexate | Stanozolol | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
663,
24,
1687
]
],
[
[
663,
24,
1546
],
[
1546,
1,
1687
]
],
[
[
663,
24,
1561
],
[
1561,
40,
1687
]
],
[
[
663,
7,
7720
],
[
7720,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resemble... |
DB00289 | DB09082 | 847 | 659 | [
"DDInter132",
"DDInter1934"
] | Atomoxetine | Vilanterol | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
847,
24,
659
]
],
[
[
847,
24,
927
],
[
927,
63,
659
]
],
[
[
847,
25,
1069
],
[
1069,
24,
659
]
],
[
[
847,
23,
222
],
[
222,
2... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Atomoxetine may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may ca... |
DB00331 | DB00500 | 1,645 | 24 | [
"DDInter1164",
"DDInter1831"
] | Metformin | Tolmetin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Moderate | 1 | [
[
[
1645,
24,
24
]
],
[
[
1645,
24,
886
],
[
886,
1,
24
]
],
[
[
1645,
63,
831
],
[
831,
40,
24
]
],
[
[
1645,
21,
28809
],
[
28809,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
],
[
"... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Tolmetin (Compound)
Metf... |
DB00539 | DB01115 | 11 | 336 | [
"DDInter1837",
"DDInter1291"
] | Toremifene | Nifedipine | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
11,
24,
336
]
],
[
[
11,
6,
7950
],
[
7950,
45,
336
]
],
[
[
11,
7,
15786
],
[
15786,
46,
336
]
],
[
[
11,
18,
5632
],
[
5632,
4... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",... | Toremifene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound)
Toremifene (Compound) upregulates TCTN1 (Gene) and TCTN1 (Gene) is upregulated by Nifedipine (Compound)
Toremifene (Compound) downregulates C10orf2 (Gene) and C10orf2 (Gene) is upregulated by Nifedipine (Compound)
Toremifene (... |
DB06699 | DB11978 | 774 | 124 | [
"DDInter493",
"DDInter822"
] | Degarelix | Glasdegib | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
774,
24,
124
]
],
[
[
774,
62,
1247
],
[
1247,
23,
124
]
],
[
[
774,
63,
1079
],
[
1079,
24,
124
]
],
[
[
774,
24,
1032
],
[
1032,
... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and T... |
DB00446 | DB00853 | 597 | 1,686 | [
"DDInter351",
"DDInter1762"
] | Chloramphenicol | Temozolomide | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
597,
24,
1686
]
],
[
[
597,
6,
8374
],
[
8374,
45,
1686
]
],
[
[
597,
18,
4930
],
[
4930,
57,
1686
]
],
[
[
597,
21,
28703
],
[
28703,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} ... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temozolomide (Compound)
Chloramphenicol (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Temozolomide (Compound)
Chloramphenicol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Temozolomid... |
DB00365 | DB00377 | 839 | 1,494 | [
"DDInter842",
"DDInter1382"
] | Grepafloxacin | Palonosetron | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Major | 2 | [
[
[
839,
25,
1494
]
],
[
[
839,
23,
112
],
[
112,
62,
1494
]
],
[
[
839,
25,
1148
],
[
1148,
63,
1494
]
],
[
[
839,
64,
600
],
[
600,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palonosetron"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Palonosetron
Grepafloxacin may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenal... |
DB00776 | DB06697 | 1,335 | 436 | [
"DDInter1360",
"DDInter121"
] | Oxcarbazepine | Artemether | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Moderate | 1 | [
[
[
1335,
24,
436
]
],
[
[
1335,
6,
7524
],
[
7524,
45,
436
]
],
[
[
1335,
24,
1220
],
[
1220,
24,
436
]
],
[
[
1335,
24,
214
],
[
214,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Artemether"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compo... | Oxcarbazepine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Artemether (Compound)
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Artemether
Oxcarb... |
DB00334 | DB01114 | 867 | 272 | [
"DDInter1326",
"DDInter362"
] | Olanzapine | Chlorpheniramine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
867,
24,
272
]
],
[
[
867,
24,
849
],
[
849,
63,
272
]
],
[
[
867,
24,
128
],
[
128,
24,
272
]
],
[
[
867,
6,
12523
],
[
12523,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00888 | DB08913 | 1,001 | 1,186 | [
"DDInter1133",
"DDInter1561"
] | Mechlorethamine | Radium Ra 223 dichloride | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1001,
24,
1186
]
],
[
[
1001,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
1001,
24,
37
],
[
37,
24,
1186
]
],
[
[
1001,
63,
134
],
[
134,
... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Mechlorethamine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Si... | Mechlorethamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00570 | DB12887 | 147 | 1,598 | [
"DDInter1936",
"DDInter1750"
] | Vinblastine | Tazemetostat | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
147,
24,
1598
]
],
[
[
147,
63,
168
],
[
168,
23,
1598
]
],
[
[
147,
24,
985
],
[
985,
24,
1598
]
],
[
[
147,
63,
134
],
[
134,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osi... |
DB00624 | DB14723 | 1,561 | 159 | [
"DDInter1776",
"DDInter1026"
] | Testosterone (topical) | Larotrectinib | Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, an androstanoid, a C19-steroid and a 3-oxo-Delta(4) steroid. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1561,
24,
159
]
],
[
[
1561,
24,
98
],
[
98,
24,
159
]
],
[
[
1561,
63,
322
],
[
322,
24,
159
]
],
[
[
1561,
40,
1197
],
[
1197,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Test... |
DB00907 | DB13139 | 290 | 1,032 | [
"DDInter427",
"DDInter1063"
] | Cocaine (topical) | Levosalbutamol | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Major | 2 | [
[
[
290,
25,
1032
]
],
[
[
290,
64,
1048
],
[
1048,
24,
1032
]
],
[
[
290,
25,
659
],
[
659,
24,
1032
]
],
[
[
290,
64,
1048
],
[
1048,
... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxapram"
],
[
"Doxapram",
"{u} may cau... | Cocaine may lead to a major life threatening interaction when taken with Levosalbutamol
Cocaine may lead to a major life threatening interaction when taken with Doxapram and Doxapram may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Cocaine may lead to a major life threateni... |
DB00480 | DB05528 | 1,668 | 1,070 | [
"DDInter1035",
"DDInter1228"
] | Lenalidomide | Mipomersen | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1668,
25,
1070
]
],
[
[
1668,
25,
14
],
[
14,
25,
1070
]
],
[
[
1668,
24,
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],
[
1320,
64,
1070
]
],
[
[
1668,
64,
581
],
[
581,
... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rosuvastatin"
],
[
"Rosuvastatin",
... | Lenalidomide may lead to a major life threatening interaction when taken with Rosuvastatin and Rosuvastatin may lead to a major life threatening interaction when taken with Mipomersen
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may lead to a major l... |
DB01208 | DB06663 | 945 | 1,154 | [
"DDInter1705",
"DDInter1398"
] | Sparfloxacin | Pasireotide | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
945,
25,
1154
]
],
[
[
945,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
945,
62,
112
],
[
112,
23,
1154
]
],
[
[
945,
24,
1385
],
[
1385,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caus... | Sparfloxacin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when t... |
DB00376 | DB00405 | 1,105 | 128 | [
"DDInter1870",
"DDInter517"
] | Trihexyphenidyl | Dexbrompheniramine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
1105,
24,
128
]
],
[
[
1105,
24,
662
],
[
662,
63,
128
]
],
[
[
1105,
1,
1386
],
[
1386,
24,
128
]
],
[
[
1105,
63,
1089
],
[
1089,
... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxa... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Trihexyphenidyl (Compound) resembles Procyclidine (Compound) and Procyclidine may cause a mod... |
DB00047 | DB00780 | 176 | 551 | [
"DDInter932",
"DDInter1440"
] | Insulin glargine | Phenelzine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Moderate | 1 | [
[
[
176,
24,
551
]
],
[
[
176,
24,
1161
],
[
1161,
40,
551
]
],
[
[
176,
24,
73
],
[
73,
25,
551
]
],
[
[
176,
24,
999
],
[
999,
24,... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline (Compound) resembles Phenelzine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may lead to a major life thre... |
DB00860 | DB09293 | 891 | 116 | [
"DDInter1513",
"DDInter954"
] | Prednisolone | Iodide I-131 | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
891,
24,
116
]
],
[
[
891,
1,
1486
],
[
1486,
24,
116
]
],
[
[
891,
40,
167
],
[
167,
24,
116
]
],
[
[
891,
24,
1004
],
[
1004,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Methylprednisolone"
],
[
"Methylprednisolone",
"{... | Prednisolone (Compound) resembles Methylprednisolone (Compound) and Methyl
Prednisolone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Prednisolone may cause a moderate interaction that could exacerbate disea... |
DB00069 | DB01362 | 367 | 497 | [
"DDInter946",
"DDInter960"
] | Interferon alfacon-1 | Iohexol | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
367,
25,
497
]
],
[
[
367,
24,
242
],
[
242,
63,
497
]
],
[
[
367,
24,
33
],
[
33,
24,
497
]
],
[
[
367,
24,
1267
],
[
1267,
64,... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
[
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Amio... |
DB01209 | DB06274 | 1,359 | 574 | [
"DDInter531",
"DDInter59"
] | Dezocine | Alvimopan | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period. | Major | 2 | [
[
[
1359,
25,
574
]
],
[
[
1359,
6,
7940
],
[
7940,
45,
574
]
],
[
[
1359,
40,
234
],
[
234,
25,
574
]
],
[
[
1359,
64,
475
],
[
475,
... | [
[
[
"Dezocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alvimopan"
]
],
[
[
"Dezocine",
"{u} (Compound) binds {v} (Gene)",
"OPRK1"
],
[
"OPRK1",
"{u} (Gene) is bound by {v} (Compound)",
"Alvimopan"
... | Dezocine (Compound) binds OPRK1 (Gene) and OPRK1 (Gene) is bound by Alvimopan (Compound)
Dezocine (Compound) resembles Pentazocine (Compound) and Pentazocine may lead to a major life threatening interaction when taken with Alvimopan
Dezocine may lead to a major life threatening interaction when taken with Morphine and ... |
DB00087 | DB12267 | 599 | 1,476 | [
"DDInter41",
"DDInter233"
] | Alemtuzumab | Brigatinib | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
599,
24,
1476
]
],
[
[
599,
24,
168
],
[
168,
23,
1476
]
],
[
[
599,
24,
629
],
[
629,
24,
1476
]
],
[
[
599,
63,
1184
],
[
1184,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolim... |
DB00372 | DB11823 | 999 | 858 | [
"DDInter1793",
"DDInter673"
] | Thiethylperazine | Esketamine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
999,
24,
858
]
],
[
[
999,
24,
272
],
[
272,
24,
858
]
],
[
[
999,
63,
1242
],
[
1242,
24,
858
]
],
[
[
999,
25,
1311
],
[
1311,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramin... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00019 | DB06595 | 1,257 | 1,491 | [
"DDInter1405",
"DDInter1214"
] | Pegfilgrastim | Midostaurin | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1257,
24,
1491
]
],
[
[
1257,
24,
1342
],
[
1342,
24,
1491
]
],
[
[
1257,
24,
1399
],
[
1399,
63,
1491
]
],
[
[
1257,
24,
39
],
[
39,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbon... |
DB06595 | DB06772 | 1,491 | 310 | [
"DDInter1214",
"DDInter259"
] | Midostaurin | Cabazitaxel | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
1491,
24,
310
]
],
[
[
1491,
63,
973
],
[
973,
24,
310
]
],
[
[
1491,
63,
307
],
[
307,
23,
310
]
],
[
[
1491,
24,
800
],
[
800,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Moda... |
DB00480 | DB00563 | 1,668 | 663 | [
"DDInter1035",
"DDInter1174"
] | Lenalidomide | Methotrexate | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1668,
24,
663
]
],
[
[
1668,
5,
11555
],
[
11555,
44,
663
]
],
[
[
1668,
6,
4973
],
[
4973,
45,
663
]
],
[
[
1668,
6,
7720
],
[
7720,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Lenalidomide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (... | Lenalidomide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Methotrexate (Compound)
Lenalidomide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Lenalidomide (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Methotrexate (C... |
DB00008 | DB00445 | 491 | 322 | [
"DDInter1407",
"DDInter655"
] | Peginterferon alfa-2a | Epirubicin | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
491,
24,
322
]
],
[
[
491,
24,
112
],
[
112,
62,
322
]
],
[
[
491,
24,
671
],
[
671,
63,
322
]
],
[
[
491,
24,
134
],
[
134,
24,... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metro... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00701 | DB00741 | 1,091 | 167 | [
"DDInter90",
"DDInter885"
] | Amprenavir | Hydrocortisone | Amprenavir is a protease inhibitor used to treat HIV infection. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1091,
24,
167
]
],
[
[
1091,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1091,
64,
303
],
[
303,
40,
167
]
],
[
[
1091,
63,
1351
],
[
1351,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Amprenavir may lead to a major life threatening interaction when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) res... |
DB00934 | DB09082 | 413 | 659 | [
"DDInter1124",
"DDInter1934"
] | Maprotiline | Vilanterol | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
413,
24,
659
]
],
[
[
413,
24,
927
],
[
927,
63,
659
]
],
[
[
413,
25,
1069
],
[
1069,
24,
659
]
],
[
[
413,
24,
222
],
[
222,
2... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Maprotiline may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may ca... |
DB01169 | DB12332 | 57 | 1,619 | [
"DDInter120",
"DDInter1626"
] | Arsenic trioxide | Rucaparib | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
57,
25,
1619
]
],
[
[
57,
62,
112
],
[
112,
23,
1619
]
],
[
[
57,
64,
87
],
[
87,
24,
1619
]
],
[
[
57,
25,
1662
],
[
1662,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Arsenic trioxide may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine... |
DB00313 | DB11901 | 556 | 913 | [
"DDInter1913",
"DDInter107"
] | Valproic acid | Apalutamide | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
556,
24,
913
]
],
[
[
556,
24,
303
],
[
303,
24,
913
]
],
[
[
556,
24,
1619
],
[
1619,
63,
913
]
],
[
[
556,
23,
286
],
[
286,
2... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone ... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Valproic acid may cause a moderate interaction that could exacerbate disea... |
DB04868 | DB06448 | 478 | 171 | [
"DDInter1293",
"DDInter1087"
] | Nilotinib | Lonafarnib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
478,
25,
171
]
],
[
[
478,
63,
222
],
[
222,
23,
171
]
],
[
[
478,
63,
254
],
[
254,
24,
171
]
],
[
[
478,
64,
888
],
[
888,
24,... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Lonafarnib
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and Nitisino... |
DB00741 | DB08904 | 167 | 375 | [
"DDInter885",
"DDInter342"
] | Hydrocortisone | Certolizumab pegol | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
167,
25,
375
]
],
[
[
167,
62,
1461
],
[
1461,
23,
375
]
],
[
[
167,
23,
1193
],
[
1193,
62,
375
]
],
[
[
167,
24,
200
],
[
200,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconat... |
DB01181 | DB09156 | 1,532 | 777 | [
"DDInter906",
"DDInter964"
] | Ifosfamide | Iopromide | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
1532,
25,
777
]
],
[
[
1532,
63,
1648
],
[
1648,
24,
777
]
],
[
[
1532,
24,
242
],
[
242,
63,
777
]
],
[
[
1532,
63,
372
],
[
372,
... | [
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
"Aldesleuki... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remde... |
DB10429 | DB11767 | 200 | 1,583 | [
"DDInter282",
"DDInter1643"
] | Candida albicans | Sarilumab | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
200,
24,
1583
]
],
[
[
200,
63,
850
],
[
850,
24,
1583
]
],
[
[
200,
24,
738
],
[
738,
63,
1583
]
],
[
[
200,
24,
1456
],
[
1456,
... | [
[
[
"Candida albicans",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Candida albicans",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedo... | Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Candida albicans may cause a moderate interaction that could exacerbate diseases when tak... |
DB00215 | DB12130 | 1,230 | 1,017 | [
"DDInter388",
"DDInter1094"
] | Citalopram | Lorlatinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1230,
24,
1017
]
],
[
[
1230,
24,
590
],
[
590,
24,
1017
]
],
[
[
1230,
24,
1421
],
[
1421,
63,
1017
]
],
[
[
1230,
25,
1491
],
[
1491... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
[... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and ... |
DB00376 | DB00427 | 1,105 | 1,233 | [
"DDInter1870",
"DDInter1879"
] | Trihexyphenidyl | Triprolidine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
1105,
24,
1233
]
],
[
[
1105,
1,
11268
],
[
11268,
40,
1233
]
],
[
[
1105,
24,
262
],
[
262,
63,
1233
]
],
[
[
1105,
35,
1192
],
[
119... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Trihexyphenidyl",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Co... | Trihexyphenidyl (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Triprolidine (Compound)
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB09083 | DB11901 | 880 | 913 | [
"DDInter996",
"DDInter107"
] | Ivabradine | Apalutamide | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
880,
25,
913
]
],
[
[
880,
64,
600
],
[
600,
24,
913
]
],
[
[
880,
24,
1320
],
[
1320,
63,
913
]
],
[
[
880,
25,
877
],
[
877,
6... | [
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fluconazole",
"{u... | Ivabradine may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Ivabradine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a... |
DB08904 | DB13985 | 375 | 546 | [
"DDInter342",
"DDInter1108"
] | Certolizumab pegol | Lutetium Lu 177 dotatate | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Major | 2 | [
[
[
375,
25,
546
]
],
[
[
375,
63,
66
],
[
66,
24,
546
]
],
[
[
375,
64,
1683
],
[
1683,
24,
546
]
],
[
[
375,
25,
270
],
[
270,
24,... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
... | Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Certolizumab pegol may lead to a major life threatening interaction when taken with Usteki... |
DB00480 | DB11793 | 1,668 | 738 | [
"DDInter1035",
"DDInter1297"
] | Lenalidomide | Niraparib | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1668,
24,
738
]
],
[
[
1668,
24,
1033
],
[
1033,
63,
738
]
],
[
[
1668,
24,
663
],
[
663,
24,
738
]
],
[
[
1668,
63,
1253
],
[
1253,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Met... |
DB00501 | DB08815 | 752 | 154 | [
"DDInter380",
"DDInter1104"
] | Cimetidine | Lurasidone | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
752,
24,
154
]
],
[
[
752,
6,
8374
],
[
8374,
45,
154
]
],
[
[
752,
21,
29175
],
[
29175,
60,
154
]
],
[
[
752,
24,
959
],
[
959,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lurasidone (Compound)
Cimetidine (Compound) causes Galactorrhoea (Side Effect) and Galactorrhoea (Side Effect) is caused by Lurasidone (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide a... |
DB00191 | DB00285 | 73 | 1,100 | [
"DDInter1447",
"DDInter1927"
] | Phentermine | Venlafaxine | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Major | 2 | [
[
[
73,
25,
1100
]
],
[
[
73,
25,
534
],
[
534,
1,
1100
]
],
[
[
73,
25,
643
],
[
643,
40,
1100
]
],
[
[
73,
6,
6017
],
[
6017,
45,
... | [
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venlafaxine"
]
],
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
],
[
"Tramadol",
"{u} (C... | Phentermine may lead to a major life threatening interaction when taken with Tramadol and Tramadol (Compound) resembles Venlafaxine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Desvenlafaxine and Desvenlafaxine (Compound) resembles Venlafaxine (Compound)
Phentermine (Compound)... |
DB00176 | DB01211 | 529 | 609 | [
"DDInter770",
"DDInter393"
] | Fluvoxamine | Clarithromycin | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
529,
24,
609
]
],
[
[
529,
6,
4973
],
[
4973,
45,
609
]
],
[
[
529,
7,
3466
],
[
3466,
46,
609
]
],
[
[
529,
21,
28662
],
[
28662,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Fluvoxamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Fluvoxamine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compound)
Fluvoxamine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)... |
DB00400 | DB08873 | 353 | 74 | [
"DDInter843",
"DDInter221"
] | Griseofulvin | Boceprevir | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
353,
24,
74
]
],
[
[
353,
6,
8374
],
[
8374,
45,
74
]
],
[
[
353,
21,
28769
],
[
28769,
60,
74
]
],
[
[
353,
24,
310
],
[
310,
2... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Griseofulvin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Boceprevir (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01220 | DB11791 | 1,088 | 785 | [
"DDInter1593",
"DDInter287"
] | Rifaximin | Capmatinib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
1088,
24,
785
]
],
[
[
1088,
24,
1320
],
[
1320,
63,
785
]
],
[
[
1088,
63,
126
],
[
126,
24,
785
]
],
[
[
1088,
24,
478
],
[
478,
... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may c... |
DB00261 | DB00574 | 702 | 121 | [
"DDInter93",
"DDInter717"
] | Anagrelide | Fenfluramine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
702,
24,
121
]
],
[
[
702,
24,
479
],
[
479,
62,
121
]
],
[
[
702,
64,
366
],
[
366,
24,
121
]
],
[
[
702,
24,
1032
],
[
1032,
6... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Fenfluramine
Anagrelide may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may caus... |
DB00619 | DB00700 | 1,419 | 312 | [
"DDInter909",
"DDInter656"
] | Imatinib | Eplerenone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Major | 2 | [
[
[
1419,
25,
312
]
],
[
[
1419,
24,
167
],
[
167,
63,
312
]
],
[
[
1419,
63,
989
],
[
989,
1,
312
]
],
[
[
1419,
24,
1561
],
[
1561,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eplerenone"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
"Hydrocorti... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and ... |
DB00668 | DB01359 | 874 | 729 | [
"DDInter652",
"DDInter1417"
] | Epinephrine | Penbutolol | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Major | 2 | [
[
[
874,
25,
729
]
],
[
[
874,
64,
461
],
[
461,
1,
729
]
],
[
[
874,
25,
699
],
[
699,
40,
729
]
],
[
[
874,
6,
3576
],
[
3576,
45,... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Penbutolol"
]
],
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Timolol"
],
[
"Timolol",
"{u} (Comp... | Epinephrine may lead to a major life threatening interaction when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Epinephrine may lead to a major life threatening interaction when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Epinephrine (Compound) binds ADRB2 (Gene... |
DB00370 | DB11963 | 1,251 | 1,045 | [
"DDInter1230",
"DDInter465"
] | Mirtazapine | Dacomitinib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
1251,
24,
1045
]
],
[
[
1251,
25,
1039
],
[
1039,
24,
1045
]
],
[
[
1251,
24,
1376
],
[
1376,
24,
1045
]
],
[
[
1251,
24,
1670
],
[
16... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"De... | Mirtazapine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Dip... |
DB00741 | DB09037 | 167 | 920 | [
"DDInter885",
"DDInter1413"
] | Hydrocortisone | Pembrolizumab | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and ... | Moderate | 1 | [
[
[
167,
24,
920
]
],
[
[
167,
1,
891
],
[
891,
24,
920
]
],
[
[
167,
25,
770
],
[
770,
25,
920
]
],
[
[
167,
1,
891
],
[
891,
1,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pembrolizumab"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Prednisolone"
],
[
"Prednisolone",
"{u} may ... | Hydrocortisone (Compound) resembles Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Pembrolizumab
Hydrocortisone may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a major life threatening inte... |
DB00994 | DB04834 | 361 | 276 | [
"DDInter1277",
"DDInter1571"
] | Neomycin | Rapacuronium | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Major | 2 | [
[
[
361,
25,
276
]
],
[
[
361,
63,
91
],
[
91,
24,
276
]
],
[
[
361,
64,
1441
],
[
1441,
24,
276
]
],
[
[
361,
62,
608
],
[
608,
24,... | [
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rapacuronium"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vancomycin",... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Neomycin may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin may cause a ... |
DB00631 | DB08880 | 372 | 1,510 | [
"DDInter405",
"DDInter1771"
] | Clofarabine | Teriflunomide | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
372,
25,
1510
]
],
[
[
372,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
372,
24,
221
],
[
221,
63,
1510
]
],
[
[
372,
24,
1136
],
[
1136,
... | [
[
[
"Clofarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 an... |
DB01175 | DB06663 | 318 | 1,154 | [
"DDInter672",
"DDInter1398"
] | Escitalopram | Pasireotide | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
318,
25,
1154
]
],
[
[
318,
63,
1314
],
[
1314,
40,
1154
]
],
[
[
318,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
318,
62,
112
],
[
112,
... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
"Des... | Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Pasireotide (Compound)
Escitalopram (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Escitalopram may cause a... |
DB00358 | DB11901 | 1,010 | 913 | [
"DDInter1140",
"DDInter107"
] | Mefloquine | Apalutamide | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1010,
24,
913
]
],
[
[
1010,
23,
112
],
[
112,
23,
913
]
],
[
[
1010,
63,
608
],
[
608,
23,
913
]
],
[
[
1010,
63,
600
],
[
600,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lido... |
DB00679 | DB06704 | 684 | 247 | [
"DDInter1796",
"DDInter951"
] | Thioridazine | Iobenguane (I-123) | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
684,
24,
247
]
],
[
[
684,
18,
7359
],
[
7359,
57,
247
]
],
[
[
684,
21,
28787
],
[
28787,
60,
247
]
],
[
[
684,
36,
820
],
[
820,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Thioridazine",
"{u} (Compound) downregulates {v} (Gene)",
"TXNDC9"
],
[
"TXNDC9",
"{u} (Gene) is downregulated... | Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Thioridazine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Iobenguane (Compound)
Thioridazine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobeng... |
DB08880 | DB10989 | 1,510 | 496 | [
"DDInter1771",
"DDInter858"
] | Teriflunomide | Hepatitis A Vaccine | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1510,
24,
496
]
],
[
[
1510,
25,
1093
],
[
1093,
63,
496
]
],
[
[
1510,
64,
4
],
[
4,
24,
496
]
],
[
[
1510,
25,
951
],
[
951,
2... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
],
[
... | Teriflunomide may lead to a major life threatening interaction when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Teriflunomide may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacet... |
DB01024 | DB01045 | 1,096 | 463 | [
"DDInter1252",
"DDInter1590"
] | Mycophenolic acid | Rifampicin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Major | 2 | [
[
[
1096,
25,
463
]
],
[
[
1096,
7,
8155
],
[
8155,
45,
463
]
],
[
[
1096,
6,
15705
],
[
15705,
45,
463
]
],
[
[
1096,
24,
115
],
[
115,
... | [
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rifampicin"
]
],
[
[
"Mycophenolic acid",
"{u} (Compound) upregulates {v} (Gene)",
"ABCC5"
],
[
"ABCC5",
"{u} (Gene) is bound by {v} (Compound... | Mycophenolic acid (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is bound by Rifampicin (Compound)
Mycophenolic acid (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Rifampicin (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxi... |
DB11113 | DB11986 | 657 | 484 | [
"DDInter307",
"DDInter648"
] | Castor oil | Entrectinib | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of, which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic,... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
657,
24,
484
]
],
[
[
657,
63,
1539
],
[
1539,
24,
484
]
],
[
[
657,
24,
180
],
[
180,
63,
484
]
],
[
[
657,
24,
927
],
[
927,
2... | [
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
],
[
... | Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine and Olicer... |
DB00814 | DB01082 | 1,171 | 1,448 | [
"DDInter1143",
"DDInter1713"
] | Meloxicam | Streptomycin | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1171,
24,
1448
]
],
[
[
1171,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
1171,
24,
1272
],
[
1272,
63,
1448
]
],
[
[
1171,
1,
1027
],
[
1... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Meloxicam",
"{u} (Compound) causes {v} (Side Effect)",
"Renal failure"
],
[
"Renal failure",
"{u} (Side Effect)... | Meloxicam (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00086 | DB15035 | 1,167 | 503 | [
"DDInter1712",
"DDInter1959"
] | Streptokinase | Zanubrutinib | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1167,
25,
503
]
],
[
[
1167,
24,
222
],
[
222,
24,
503
]
],
[
[
1167,
25,
39
],
[
39,
25,
503
]
],
[
[
1167,
24,
1018
],
[
1018,
... | [
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"S... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Streptokinase may lead to a major life threatening interaction when taken with Panobinostat and Panobinos... |
DB00679 | DB00986 | 684 | 1,192 | [
"DDInter1796",
"DDInter834"
] | Thioridazine | Glycopyrronium | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
684,
24,
1192
]
],
[
[
684,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
684,
24,
262
],
[
262,
24,
1192
]
],
[
[
684,
6,
4304
],
[
4304,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],... | Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium a... |
DB00738 | DB04844 | 485 | 843 | [
"DDInter1420",
"DDInter1778"
] | Pentamidine | Tetrabenazine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
485,
24,
843
]
],
[
[
485,
24,
479
],
[
479,
40,
843
]
],
[
[
485,
6,
12523
],
[
12523,
45,
843
]
],
[
[
485,
18,
4495
],
[
4495,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Pentamidine (Compound) downregulates CBR1 (Gene) and CBR1 (G... |
DB00501 | DB00652 | 752 | 234 | [
"DDInter380",
"DDInter1421"
] | Cimetidine | Pentazocine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Moderate | 1 | [
[
[
752,
24,
234
]
],
[
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752,
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[
28762,
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[
[
752,
24,
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[
1264,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Dezocine and Dezocine (Compound) resembles Pentazocine (Compound)
Cimetidine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Pentazocine (Compound)
Cimetidine may cause a moderate interaction that... |
DB09080 | DB11796 | 144 | 1,612 | [
"DDInter1331",
"DDInter786"
] | Olodaterol | Fostemsavir | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
144,
24,
1612
]
],
[
[
144,
63,
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[
1324,
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[
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144,
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],
[
1424,
24,
1612
]
],
[
[
144,
24,
823
],
[
823,
... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[... | Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinin... |
DB00289 | DB01142 | 847 | 1,264 | [
"DDInter132",
"DDInter593"
] | Atomoxetine | Doxepin | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Minor | 0 | [
[
[
847,
23,
1264
]
],
[
[
847,
24,
401
],
[
401,
24,
1264
]
],
[
[
847,
1,
1594
],
[
1594,
24,
1264
]
],
[
[
847,
40,
11355
],
[
11355,
... | [
[
[
"Atomoxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doxepin"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Atomoxetine (Compound) resembles Doxylamine (Compound) and Doxylamine may cause a moderate interaction that co... |
DB00554 | DB06081 | 1,027 | 1,046 | [
"DDInter1478",
"DDInter286"
] | Piroxicam | Caplacizumab | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Moderate | 1 | [
[
[
1027,
24,
1046
]
],
[
[
1027,
24,
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],
[
1039,
24,
1046
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],
[
[
1027,
40,
1171
],
[
1171,
24,
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]
],
[
[
1027,
63,
1061
],
[
10... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caplacizumab"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab
Piroxicam (Compound) resembles Meloxicam (Compound) and Meloxicam may cause a moderate interaction th... |
DB00230 | DB01069 | 784 | 401 | [
"DDInter1516",
"DDInter1533"
] | Pregabalin | Promethazine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
784,
24,
401
]
],
[
[
784,
24,
1264
],
[
1264,
63,
401
]
],
[
[
784,
24,
104
],
[
104,
24,
401
]
],
[
[
784,
21,
28709
],
[
28709,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdila... |
DB01124 | DB06077 | 1,411 | 879 | [
"DDInter1828",
"DDInter1102"
] | Tolbutamide | Lumateperone | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1411,
24,
879
]
],
[
[
1411,
24,
1281
],
[
1281,
63,
879
]
],
[
[
1411,
63,
1645
],
[
1645,
24,
879
]
],
[
[
1411,
24,
170
],
[
170,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Metformin and M... |
DB01177 | DB11943 | 77 | 255 | [
"DDInter904",
"DDInter495"
] | Idarubicin | Delafloxacin | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
77,
23,
255
]
],
[
[
77,
63,
1001
],
[
1001,
23,
255
]
],
[
[
77,
24,
37
],
[
37,
23,
255
]
],
[
[
77,
74,
322
],
[
322,
23,
... | [
[
[
"Idarubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Lomustine a... |
DB00215 | DB01114 | 1,230 | 272 | [
"DDInter388",
"DDInter362"
] | Citalopram | Chlorpheniramine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1230,
24,
272
]
],
[
[
1230,
24,
849
],
[
849,
63,
272
]
],
[
[
1230,
24,
128
],
[
128,
24,
272
]
],
[
[
1230,
24,
28
],
[
28,
1... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00252 | DB01611 | 362 | 1,487 | [
"DDInter1460",
"DDInter893"
] | Phenytoin | Hydroxychloroquine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
362,
24,
1487
]
],
[
[
362,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
362,
24,
663
],
[
663,
23,
1487
]
],
[
[
362,
24,
723
],
[
723,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Phenytoin",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is ... | Phenytoin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with H... |
DB00372 | DB00842 | 999 | 686 | [
"DDInter1793",
"DDInter1359"
] | Thiethylperazine | Oxazepam | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
999,
24,
686
]
],
[
[
999,
63,
695
],
[
695,
40,
686
]
],
[
[
999,
24,
1119
],
[
1119,
1,
686
]
],
[
[
999,
63,
1174
],
[
1174,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Ox... |
DB06273 | DB09237 | 980 | 1,586 | [
"DDInter1824",
"DDInter1045"
] | Tocilizumab | Levamlodipine | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
980,
24,
1586
]
],
[
[
980,
25,
908
],
[
908,
24,
1586
]
],
[
[
980,
24,
384
],
[
384,
24,
1586
]
],
[
[
980,
64,
1184
],
[
1184,
... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Tocilizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
],
[
"Golimu... | Tocilizumab may lead to a major life threatening interaction when taken with Golimumab and Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine
Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cau... |
DB05273 | DB06772 | 507 | 310 | [
"DDInter1638",
"DDInter259"
] | Samarium (153Sm) lexidronam | Cabazitaxel | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Major | 2 | [
[
[
507,
25,
310
]
],
[
[
507,
64,
973
],
[
973,
24,
310
]
],
[
[
507,
25,
800
],
[
800,
63,
310
]
],
[
[
507,
25,
1626
],
[
1626,
2... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
],
... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Duvelisib and Du... |
DB01254 | DB09054 | 1,213 | 384 | [
"DDInter484",
"DDInter905"
] | Dasatinib | Idelalisib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1213,
25,
384
]
],
[
[
1213,
63,
222
],
[
222,
23,
384
]
],
[
[
1213,
64,
318
],
[
318,
23,
384
]
],
[
[
1213,
23,
907
],
[
907,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Dasatinib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may caus... |
DB01070 | DB09146 | 1,098 | 489 | [
"DDInter558",
"DDInter978"
] | Dihydrotachysterol | Iron sucrose | A vitamin D that can be regarded as a reduction product of vitamin D2. | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1098,
24,
489
]
],
[
[
1098,
64,
386
],
[
386,
24,
489
]
],
[
[
1098,
75,
1331
],
[
1331,
24,
489
]
],
[
[
1098,
25,
1196
],
[
1196,
... | [
[
[
"Dihydrotachysterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Dihydrotachysterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cholecalciferol"
],
... | Dihydrotachysterol may lead to a major life threatening interaction when taken with Cholecalciferol and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Dihydrotachysterol (Compound) resembles Ergocalciferol (Compound) and Dihydrotachysterol may lead to a majo... |
DB00252 | DB00254 | 362 | 964 | [
"DDInter1460",
"DDInter598"
] | Phenytoin | Doxycycline | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Moderate | 1 | [
[
[
362,
24,
964
]
],
[
[
362,
6,
8374
],
[
8374,
45,
964
]
],
[
[
362,
24,
1424
],
[
1424,
62,
964
]
],
[
[
362,
63,
1685
],
[
1685,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenytoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Phenytoin may cause a mode... |
DB00381 | DB11730 | 376 | 351 | [
"DDInter79",
"DDInter1588"
] | Amlodipine | Ribociclib | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
376,
24,
351
]
],
[
[
376,
23,
466
],
[
466,
62,
351
]
],
[
[
376,
24,
283
],
[
283,
62,
351
]
],
[
[
376,
24,
597
],
[
597,
24,... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Amlodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Amlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB01059 | DB01132 | 956 | 1,130 | [
"DDInter1313",
"DDInter1472"
] | Norfloxacin | Pioglitazone | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
956,
24,
1130
]
],
[
[
956,
6,
8374
],
[
8374,
45,
1130
]
],
[
[
956,
21,
28661
],
[
28661,
60,
1130
]
],
[
[
956,
63,
688
],
[
688,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pioglitazone (Compound)
Norfloxacin (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Pioglitazone (Compound)
Norfloxacin may cause a moderate interaction that could exacerbate diseases ... |
DB00056 | DB08886 | 816 | 637 | [
"DDInter814",
"DDInter126"
] | Gemtuzumab ozogamicin | Asparaginase Erwinia chrysanthemi | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
816,
24,
637
]
],
[
[
816,
24,
850
],
[
850,
24,
637
]
],
[
[
816,
24,
1613
],
[
1613,
63,
637
]
],
[
[
816,
25,
581
],
[
581,
2... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken ... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Gemtuzumab ozogamicin may cause a moderate interaction that ... |
DB01229 | DB10316 | 973 | 334 | [
"DDInter1378",
"DDInter1248"
] | Paclitaxel (protein-bound) | Mumps virus strain B level jeryl lynn live antigen | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
973,
25,
334
]
],
[
[
973,
64,
1057
],
[
1057,
25,
334
]
],
[
[
973,
25,
908
],
[
908,
25,
334
]
],
[
[
973,
24,
310
],
[
310,
2... | [
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Paclitaxel may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Paclitaxel may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level... |
DB00792 | DB11601 | 832 | 1,270 | [
"DDInter1878",
"DDInter1889"
] | Tripelennamine | Tuberculin purified protein derivative | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
832,
24,
1270
]
],
[
[
832,
63,
13
],
[
13,
24,
1270
]
],
[
[
832,
24,
1053
],
[
1053,
24,
1270
]
],
[
[
832,
74,
662
],
[
662,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Tripelennamine may cause a moderate interaction that could exacerbate di... |
DB09075 | DB15035 | 498 | 503 | [
"DDInter621",
"DDInter1959"
] | Edoxaban | Zanubrutinib | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
498,
25,
503
]
],
[
[
498,
64,
868
],
[
868,
24,
503
]
],
[
[
498,
63,
222
],
[
222,
24,
503
]
],
[
[
498,
25,
1320
],
[
1320,
2... | [
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafenib",
"{u} m... | Edoxaban may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may caus... |
DB00603 | DB06273 | 303 | 980 | [
"DDInter1137",
"DDInter1824"
] | Medroxyprogesterone acetate | Tocilizumab | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
303,
24,
980
]
],
[
[
303,
24,
629
],
[
629,
24,
980
]
],
[
[
303,
63,
58
],
[
58,
24,
980
]
],
[
[
303,
24,
655
],
[
655,
63,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when... |
DB00812 | DB13620 | 998 | 948 | [
"DDInter1451",
"DDInter1499"
] | Phenylbutazone | Potassium gluconate | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Moderate | 1 | [
[
[
998,
24,
948
]
],
[
[
998,
24,
848
],
[
848,
24,
948
]
],
[
[
998,
63,
1512
],
[
1512,
24,
948
]
],
[
[
998,
1,
97
],
[
97,
24,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Diclof... |
DB08882 | DB11978 | 1,281 | 124 | [
"DDInter1070",
"DDInter822"
] | Linagliptin | Glasdegib | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1281,
24,
124
]
],
[
[
1281,
63,
739
],
[
739,
24,
124
]
],
[
[
1281,
24,
98
],
[
98,
24,
124
]
],
[
[
1281,
24,
1320
],
[
1320,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Som... |
DB01044 | DB01268 | 246 | 1,151 | [
"DDInter809",
"DDInter1731"
] | Gatifloxacin | Sunitinib | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
246,
25,
1151
]
],
[
[
246,
18,
8386
],
[
8386,
46,
1151
]
],
[
[
246,
7,
2067
],
[
2067,
46,
1151
]
],
[
[
246,
18,
2801
],
[
2801,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) downregulates {v} (Gene)",
"MTHFD2"
],
[
"MTHFD2",
"{u} (Gene) is upregulated by {v} (Compound)... | Gatifloxacin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Sunitinib (Compound)
Gatifloxacin (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Sunitinib (Compound)
Gatifloxacin (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Sunitinib (Compoun... |
DB01229 | DB08899 | 973 | 129 | [
"DDInter1378",
"DDInter649"
] | Paclitaxel (protein-bound) | Enzalutamide | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
973,
24,
129
]
],
[
[
973,
63,
918
],
[
918,
1,
129
]
],
[
[
973,
6,
8374
],
[
8374,
45,
129
]
],
[
[
973,
21,
29377
],
[
29377,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Paclitaxel (Compound) binds CYP3A4 (Gene) and CYP3... |
DB00983 | DB01037 | 480 | 1,161 | [
"DDInter776",
"DDInter1653"
] | Formoterol | Selegiline | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Moderate | 1 | [
[
[
480,
24,
1161
]
],
[
[
480,
63,
551
],
[
551,
1,
1161
]
],
[
[
480,
24,
1529
],
[
1529,
1,
1161
]
],
[
[
480,
24,
280
],
[
280,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Selegiline (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Selegiline (Comp... |
DB00445 | DB01097 | 322 | 1,377 | [
"DDInter655",
"DDInter1033"
] | Epirubicin | Leflunomide | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
322,
25,
1377
]
],
[
[
322,
7,
2602
],
[
2602,
45,
1377
]
],
[
[
322,
7,
9489
],
[
9489,
46,
1377
]
],
[
[
322,
18,
8386
],
[
8386,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Epirubicin",
"{u} (Compound) upregulates {v} (Gene)",
"PTK2B"
],
[
"PTK2B",
"{u} (Gene) is bound by {v} (Compound)",
"Le... | Epirubicin (Compound) upregulates PTK2B (Gene) and PTK2B (Gene) is bound by Leflunomide (Compound)
Epirubicin (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Leflunomide (Compound)
Epirubicin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Leflunomide (Compound)
Epirubi... |
DB00063 | DB11071 | 366 | 1,004 | [
"DDInter659",
"DDInter1449"
] | Eptifibatide | Phenyl salicylate | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
366,
24,
1004
]
],
[
[
366,
25,
500
],
[
500,
24,
1004
]
],
[
[
366,
25,
235
],
[
235,
63,
1004
]
],
[
[
366,
64,
834
],
[
834,
... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
... | Eptifibatide may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Eptifibatide may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a mode... |
DB00065 | DB09073 | 581 | 951 | [
"DDInter923",
"DDInter1379"
] | Infliximab | Palbociclib | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
581,
25,
951
]
],
[
[
581,
24,
496
],
[
496,
63,
951
]
],
[
[
581,
25,
1476
],
[
1476,
63,
951
]
],
[
[
581,
24,
1454
],
[
1454,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
[
"... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Infliximab may lead to a major life threatening interaction when taken with Brigatinib and Br... |
DB06168 | DB06674 | 1,531 | 908 | [
"DDInter281",
"DDInter837"
] | Canakinumab | Golimumab | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1531,
25,
908
]
],
[
[
1531,
23,
1193
],
[
1193,
62,
908
]
],
[
[
1531,
62,
1461
],
[
1461,
23,
908
]
],
[
[
1531,
63,
336
],
[
336,
... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Canakinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gl... | Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Canakinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB06697 | DB14723 | 436 | 159 | [
"DDInter121",
"DDInter1026"
] | Artemether | Larotrectinib | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
436,
24,
159
]
],
[
[
436,
24,
98
],
[
98,
24,
159
]
],
[
[
436,
63,
307
],
[
307,
24,
159
]
],
[
[
436,
24,
1654
],
[
1654,
63,... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[
... | Artemether may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Artemether may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafini... |
DB00683 | DB05679 | 1,382 | 1,683 | [
"DDInter1212",
"DDInter1907"
] | Midazolam | Ustekinumab | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1382,
24,
1683
]
],
[
[
1382,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
1382,
62,
1573
],
[
1573,
24,
1683
]
],
[
[
1382,
24,
478
],
[
478... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Midazolam may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone ma... |
DB00372 | DB00697 | 999 | 876 | [
"DDInter1793",
"DDInter1821"
] | Thiethylperazine | Tizanidine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
999,
24,
876
]
],
[
[
999,
24,
1617
],
[
1617,
1,
876
]
],
[
[
999,
24,
401
],
[
401,
63,
876
]
],
[
[
999,
24,
19
],
[
19,
24,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Tizanidine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate ... |
DB00615 | DB12267 | 690 | 1,476 | [
"DDInter1589",
"DDInter233"
] | Rifabutin | Brigatinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
690,
25,
1476
]
],
[
[
690,
24,
1135
],
[
1135,
23,
1476
]
],
[
[
690,
64,
168
],
[
168,
23,
1476
]
],
[
[
690,
25,
629
],
[
629,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Rifabutin may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a mino... |
DB00903 | DB01082 | 1,680 | 1,448 | [
"DDInter686",
"DDInter1713"
] | Etacrynic acid | Streptomycin | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Major | 2 | [
[
[
1680,
25,
1448
]
],
[
[
1680,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
1680,
21,
28882
],
[
28882,
60,
1448
]
],
[
[
1680,
25,
361
],
[
... | [
[
[
"Etacrynic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Streptomycin"
]
],
[
[
"Etacrynic acid",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compound)",
... | Etacrynic acid (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Etacrynic acid (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Streptomycin (Compound)
Etacrynic acid may lead to a major life threatening interactio... |
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