drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00845 | DB09082 | 1,490 | 659 | [
"DDInter406",
"DDInter1934"
] | Clofazimine | Vilanterol | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1490,
24,
659
]
],
[
[
1490,
24,
927
],
[
927,
63,
659
]
],
[
[
1490,
25,
1069
],
[
1069,
24,
659
]
],
[
[
1490,
63,
485
],
[
485,
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Clofazimine may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may ca... |
DB04938 | DB09280 | 1,423 | 1,604 | [
"DDInter1353",
"DDInter1101"
] | Ospemifene | Lumacaftor | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
1423,
24,
1604
]
],
[
[
1423,
63,
522
],
[
522,
24,
1604
]
],
[
[
1423,
63,
478
],
[
478,
25,
1604
]
],
[
[
1423,
74,
11
],
[
11,
... | [
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
[
... | Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilot... |
DB00472 | DB08865 | 758 | 1,593 | [
"DDInter758",
"DDInter448"
] | Fluoxetine | Crizotinib | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
758,
25,
1593
]
],
[
[
758,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
758,
7,
1986
],
[
1986,
46,
1593
]
],
[
[
758,
18,
9275
],
[
9275,
... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizoti... | Fluoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Fluoxetine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Crizotinib (Compound)
Fluoxetine (Compound) downregulates RNF167 (Gene) and RNF167 (Gene) is upregulated by Crizotinib (Compound)
Fluoxetine (... |
DB00349 | DB06723 | 902 | 115 | [
"DDInter401",
"DDInter58"
] | Clobazam | Aluminum hydroxide | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
902,
23,
115
]
],
[
[
902,
21,
28643
],
[
28643,
60,
115
]
],
[
[
902,
40,
523
],
[
523,
23,
115
]
],
[
[
902,
63,
1018
],
[
1018,
... | [
[
[
"Clobazam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Clobazam",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effect) is ca... | Clobazam (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Clobazam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Clobazam may cause a moderate inte... |
DB00332 | DB00572 | 1,089 | 85 | [
"DDInter970",
"DDInter136"
] | Ipratropium | Atropine | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
1089,
24,
85
]
],
[
[
1089,
35,
19
],
[
19,
24,
85
]
],
[
[
1089,
63,
357
],
[
357,
24,
85
]
],
[
[
1089,
40,
1177
],
[
1177,
40... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Ipratropium",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken w... | Ipratropium (Compound) resembles Hyoscyamine (Compound) and Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Ipratropium may cause a moderate interaction that c... |
DB01612 | DB04948 | 1,637 | 1,084 | [
"DDInter92",
"DDInter1083"
] | Amyl Nitrite | Lofexidine | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
1637,
24,
1084
]
],
[
[
1637,
63,
1617
],
[
1617,
1,
1084
]
],
[
[
1637,
63,
530
],
[
530,
24,
1084
]
],
[
[
1637,
24,
1450
],
[
1450,... | [
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
... | Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction ... |
DB01098 | DB11791 | 14 | 785 | [
"DDInter1622",
"DDInter287"
] | Rosuvastatin | Capmatinib | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
14,
24,
785
]
],
[
[
14,
24,
868
],
[
868,
24,
785
]
],
[
[
14,
63,
482
],
[
482,
24,
785
]
],
[
[
14,
62,
600
],
[
600,
24,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and ... |
DB00619 | DB11828 | 1,419 | 1,406 | [
"DDInter909",
"DDInter1281"
] | Imatinib | Neratinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
1419,
25,
1406
]
],
[
[
1419,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
1419,
24,
392
],
[
392,
24,
1406
]
],
[
[
1419,
25,
1510
],
[
1510... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may caus... | Imatinib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate ... |
DB00687 | DB11113 | 870 | 657 | [
"DDInter747",
"DDInter307"
] | Fludrocortisone | Castor oil | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
870,
24,
657
]
],
[
[
870,
25,
540
],
[
540,
24,
657
]
],
[
[
870,
24,
1326
],
[
1326,
24,
657
]
],
[
[
870,
1,
891
],
[
891,
24... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
... | Fludrocortisone may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclof... |
DB01229 | DB04855 | 973 | 540 | [
"DDInter1378",
"DDInter602"
] | Paclitaxel (protein-bound) | Dronedarone | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
973,
24,
540
]
],
[
[
973,
63,
33
],
[
33,
40,
540
]
],
[
[
973,
6,
8374
],
[
8374,
45,
540
]
],
[
[
973,
21,
28883
],
[
28883,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Paclitaxel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Ge... |
DB00048 | DB00086 | 1,595 | 1,167 | [
"DDInter435",
"DDInter1712"
] | Collagenase clostridium histolyticum | Streptokinase | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Moderate | 1 | [
[
[
1595,
24,
1167
]
],
[
[
1595,
24,
1317
],
[
1317,
63,
1167
]
],
[
[
1595,
24,
553
],
[
553,
64,
1167
]
],
[
[
1595,
63,
1578
],
[
1578... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptokinase"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases w... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole and Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Streptokinase
Collagenase clostridium histolyticum may cause a moderate interaction that coul... |
DB00713 | DB09420 | 1,138 | 1,074 | [
"DDInter1354",
"DDInter953"
] | Oxacillin | Iodide I-123 | An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1138,
24,
1074
]
],
[
[
1138,
40,
339
],
[
339,
24,
1074
]
],
[
[
1138,
63,
126
],
[
126,
24,
1074
]
],
[
[
1138,
1,
1681
],
[
1681,
... | [
[
[
"Oxacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Oxacillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicillin",
"{u} may cause a m... | Oxacillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Oxacillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that cou... |
DB00059 | DB00635 | 1,560 | 1,573 | [
"DDInter1404",
"DDInter1515"
] | Pegaspargase | Prednisone | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
1560,
24,
1573
]
],
[
[
1560,
24,
175
],
[
175,
40,
1573
]
],
[
[
1560,
24,
251
],
[
251,
1,
1573
]
],
[
[
1560,
24,
1018
],
[
1018,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Predni... |
DB00030 | DB00468 | 1,685 | 1,424 | [
"DDInter934",
"DDInter1557"
] | Insulin human | Quinine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Moderate | 1 | [
[
[
1685,
24,
1424
]
],
[
[
1685,
24,
1247
],
[
1247,
62,
1424
]
],
[
[
1685,
24,
964
],
[
964,
23,
1424
]
],
[
[
1685,
24,
673
],
[
673,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Quinine
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Doxycycl... |
DB01203 | DB12267 | 699 | 1,476 | [
"DDInter1255",
"DDInter233"
] | Nadolol | Brigatinib | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
699,
24,
1476
]
],
[
[
699,
63,
176
],
[
176,
24,
1476
]
],
[
[
699,
23,
578
],
[
578,
24,
1476
]
],
[
[
699,
40,
729
],
[
729,
... | [
[
[
"Nadolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Nadolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
],
[
... | Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Nadolol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ti... |
DB00745 | DB12267 | 307 | 1,476 | [
"DDInter1236",
"DDInter233"
] | Modafinil | Brigatinib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
307,
25,
1476
]
],
[
[
307,
23,
1135
],
[
1135,
23,
1476
]
],
[
[
307,
62,
168
],
[
168,
23,
1476
]
],
[
[
307,
24,
629
],
[
629,
... | [
[
[
"Modafinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Modafinil may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may c... |
DB00747 | DB13913 | 1,442 | 1,536 | [
"DDInter1647",
"DDInter175"
] | Scopolamine | Belladonna | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
1442,
24,
1536
]
],
[
[
1442,
24,
849
],
[
849,
24,
1536
]
],
[
[
1442,
63,
128
],
[
128,
24,
1536
]
],
[
[
1442,
74,
85
],
[
85,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine ... |
DB00554 | DB09418 | 1,027 | 554 | [
"DDInter1478",
"DDInter1501"
] | Piroxicam | Potassium perchlorate | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Moderate | 1 | [
[
[
1027,
24,
554
]
],
[
[
1027,
40,
1171
],
[
1171,
24,
554
]
],
[
[
1027,
24,
1274
],
[
1274,
24,
554
]
],
[
[
1027,
40,
1171
],
[
1171,... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Piroxicam",
"{u} (Compound) resembles {v} (Compound)",
"Meloxicam"
],
[
"Meloxicam",
"{u} may cause a ... | Piroxicam (Compound) resembles Meloxicam (Compound) and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction... |
DB00816 | DB09241 | 1,674 | 1,629 | [
"DDInter1346",
"DDInter1186"
] | Orciprenaline | Methylene blue | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Moderate | 1 | [
[
[
1674,
24,
1629
]
],
[
[
1674,
24,
1052
],
[
1052,
24,
1629
]
],
[
[
1674,
35,
1148
],
[
1148,
24,
1629
]
],
[
[
1674,
63,
1240
],
[
12... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylene blue"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
],... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Orciprenaline (Compound) resembles Isoprenaline (Compound) and Orciprenaline may cause a moderate interacti... |
DB00951 | DB09570 | 1,072 | 1,480 | [
"DDInter986",
"DDInter1002"
] | Isoniazid | Ixazomib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1072,
24,
1480
]
],
[
[
1072,
63,
268
],
[
268,
24,
1480
]
],
[
[
1072,
24,
148
],
[
148,
63,
1480
]
],
[
[
1072,
24,
310
],
[
310,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Sec... |
DB00491 | DB01067 | 127 | 959 | [
"DDInter1217",
"DDInter826"
] | Miglitol | Glipizide | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
127,
24,
959
]
],
[
[
127,
63,
245
],
[
245,
40,
959
]
],
[
[
127,
24,
1411
],
[
1411,
1,
959
]
],
[
[
127,
5,
11640
],
[
11640,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
Mi... |
DB00631 | DB10583 | 372 | 949 | [
"DDInter405",
"DDInter415"
] | Clofarabine | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
372,
24,
949
]
],
[
[
372,
63,
589
],
[
589,
24,
949
]
],
[
[
372,
24,
250
],
[
250,
24,
949
]
],
[
[
372,
25,
1377
],
[
1377,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Clofarabine may cause a moderate interaction that could exacerb... |
DB01166 | DB06636 | 477 | 1,623 | [
"DDInter379",
"DDInter980"
] | Cilostazol | Isavuconazonium | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Major | 2 | [
[
[
477,
25,
1623
]
],
[
[
477,
63,
222
],
[
222,
23,
1623
]
],
[
[
477,
64,
1419
],
[
1419,
24,
1623
]
],
[
[
477,
63,
1557
],
[
1557,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibu... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Isavuconazonium
Cilostazol may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause... |
DB00883 | DB09038 | 426 | 1,450 | [
"DDInter989",
"DDInter636"
] | Isosorbide dinitrate | Empagliflozin | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
426,
24,
1450
]
],
[
[
426,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
426,
24,
885
],
[
885,
24,
1450
]
],
[
[
426,
25,
1455
],
[
1455,
... | [
[
[
"Isosorbide dinitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Isosorbide dinitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trep... | Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken... |
DB01234 | DB08883 | 1,220 | 1,597 | [
"DDInter513",
"DDInter1428"
] | Dexamethasone | Perampanel | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
1220,
24,
1597
]
],
[
[
1220,
63,
609
],
[
609,
23,
1597
]
],
[
[
1220,
24,
868
],
[
868,
24,
1597
]
],
[
[
1220,
63,
1051
],
[
1051,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Perampanel
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafen... |
DB00078 | DB09498 | 1,172 | 810 | [
"DDInter898",
"DDInter1715"
] | Ibritumomab tiuxetan | Strontium chloride Sr-89 | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1172,
24,
810
]
],
[
[
1172,
24,
597
],
[
597,
24,
810
]
],
[
[
1172,
25,
273
],
[
273,
24,
810
]
],
[
[
1172,
25,
503
],
[
503,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Ibritumomab tiuxetan may lead to a major life threatening interaction when tak... |
DB00877 | DB01394 | 629 | 1,554 | [
"DDInter1678",
"DDInter431"
] | Sirolimus | Colchicine | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Moderate | 1 | [
[
[
629,
24,
1554
]
],
[
[
629,
6,
4973
],
[
4973,
45,
1554
]
],
[
[
629,
18,
2183
],
[
2183,
46,
1554
]
],
[
[
629,
7,
3222
],
[
3222,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colchicine"
]
],
[
[
"Sirolimus",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Colchicine (Compound)
Sirolimus (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by Colchicine (Compound)
Sirolimus (Compound) upregulates DUSP4 (Gene) and DUSP4 (Gene) is upregulated by Colchicine (Compound)
Sirolimus (Compound) ... |
DB06603 | DB08881 | 39 | 868 | [
"DDInter1387",
"DDInter1925"
] | Panobinostat | Vemurafenib | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
39,
25,
868
]
],
[
[
39,
62,
211
],
[
211,
23,
868
]
],
[
[
39,
63,
122
],
[
122,
23,
868
]
],
[
[
39,
24,
578
],
[
578,
24,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Panobinostat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
],
[
"Tolter... | Panobinostat may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Vera... |
DB00146 | DB00524 | 160 | 811 | [
"DDInter265",
"DDInter1199"
] | Calcifediol | Metolazone | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Moderate | 1 | [
[
[
160,
24,
811
]
],
[
[
160,
24,
1605
],
[
1605,
40,
811
]
],
[
[
160,
24,
1014
],
[
1014,
1,
811
]
],
[
[
160,
25,
1331
],
[
1331,
... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
[
... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Metolazone (Compound)
Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Metolazone (Comp... |
DB00254 | DB01294 | 964 | 266 | [
"DDInter598",
"DDInter215"
] | Doxycycline | Bismuth subsalicylate | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of [salicylic acid] linked to trivalent [bismuth cation]. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth s... | Moderate | 1 | [
[
[
964,
24,
266
]
],
[
[
964,
40,
1620
],
[
1620,
24,
266
]
],
[
[
964,
24,
1254
],
[
1254,
63,
266
]
],
[
[
964,
63,
176
],
[
176,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bismuth subsalicylate"
]
],
[
[
"Doxycycline",
"{u} (Compound) resembles {v} (Compound)",
"Tetracycline"
],
[
"Tetracycline",
"{u} ma... | Doxycycline (Compound) resembles Tetracycline (Compound) and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Bismuth subsalicylate
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a ... |
DB01591 | DB14723 | 667 | 159 | [
"DDInter1696",
"DDInter1026"
] | Solifenacin | Larotrectinib | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
667,
24,
159
]
],
[
[
667,
24,
98
],
[
98,
24,
159
]
],
[
[
667,
63,
597
],
[
597,
24,
159
]
],
[
[
667,
64,
11
],
[
11,
24,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[... | Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and ... |
DB00002 | DB00544 | 1,284 | 970 | [
"DDInter344",
"DDInter757"
] | Cetuximab | Fluorouracil | Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it... | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Moderate | 1 | [
[
[
1284,
24,
970
]
],
[
[
1284,
24,
1555
],
[
1555,
24,
970
]
],
[
[
1284,
24,
384
],
[
384,
63,
970
]
],
[
[
1284,
25,
770
],
[
770,
... | [
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
]
],
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil
Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idel... |
DB00683 | DB09154 | 1,382 | 1,475 | [
"DDInter1212",
"DDInter1686"
] | Midazolam | Sodium citrate | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Minor | 0 | [
[
[
1382,
23,
1475
]
],
[
[
1382,
1,
902
],
[
902,
23,
1475
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],
[
[
1382,
24,
1250
],
[
1250,
24,
1475
]
],
[
[
1382,
23,
115
],
[
115,
... | [
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium citrate"
]
],
[
[
"Midazolam",
"{u} (Compound) resembles {v} (Compound)",
"Clobazam"
],
[
"Clobazam",
"{u} may cause a minor inter... | Midazolam (Compound) resembles Clobazam (Compound) and Clobazam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazopanib may cause a moderate interaction that could exace... |
DB00916 | DB12240 | 112 | 110 | [
"DDInter1202",
"DDInter1485"
] | Metronidazole | Polatuzumab vedotin | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
112,
24,
110
]
],
[
[
112,
23,
129
],
[
129,
23,
110
]
],
[
[
112,
63,
467
],
[
467,
24,
110
]
],
[
[
112,
24,
980
],
[
980,
24,... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enzalutamide"
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Simvas... |
DB00446 | DB09049 | 597 | 1,135 | [
"DDInter351",
"DDInter1261"
] | Chloramphenicol | Naloxegol | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
597,
25,
1135
]
],
[
[
597,
24,
33
],
[
33,
23,
1135
]
],
[
[
597,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
597,
24,
971
],
[
971,
... | [
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
],
[
"A... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Chloramphenicol may lead to a major life threatening interaction when taken with Neratinib and Neratinib may c... |
DB00682 | DB03404 | 126 | 765 | [
"DDInter1951",
"DDInter855"
] | Warfarin | Hemin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Moderate | 1 | [
[
[
126,
24,
765
]
],
[
[
126,
25,
840
],
[
840,
63,
765
]
],
[
[
126,
64,
291
],
[
291,
24,
765
]
],
[
[
126,
63,
1018
],
[
1018,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
],
[
"Vorapaxar",
"{... | Warfarin may lead to a major life threatening interaction when taken with Vorapaxar and Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Hemin
Warfarin may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a moderate interaction tha... |
DB01577 | DB09045 | 1,529 | 52 | [
"DDInter1161",
"DDInter607"
] | Metamfetamine | Dulaglutide | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1529,
24,
52
]
],
[
[
1529,
63,
170
],
[
170,
23,
52
]
],
[
[
1529,
1,
280
],
[
280,
24,
52
]
],
[
[
1529,
75,
73
],
[
73,
24,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Metamfetamine (Compound) resembles Mephentermine (Compound) and Mephentermine may cause a moderate interacti... |
DB01129 | DB01592 | 379 | 1,596 | [
"DDInter1559",
"DDInter975"
] | Rabeprazole | Iron | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
379,
24,
1596
]
],
[
[
379,
21,
29024
],
[
29024,
60,
1596
]
],
[
[
379,
63,
955
],
[
955,
23,
1596
]
],
[
[
379,
1,
1215
],
[
1215,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Rabeprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is ca... | Rabeprazole (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Iron (Compound)
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil may cause a minor interaction that can limit clinical effects w... |
DB00280 | DB00748 | 494 | 662 | [
"DDInter575",
"DDInter297"
] | Disopyramide | Carbinoxamine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
494,
24,
662
]
],
[
[
494,
24,
28
],
[
28,
40,
662
]
],
[
[
494,
35,
1594
],
[
1594,
24,
662
]
],
[
[
494,
24,
128
],
[
128,
24,... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
],
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Disopyramide (Compound) resembles Doxylamine (Compound) and Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Doxy... |
DB00529 | DB00860 | 789 | 891 | [
"DDInter779",
"DDInter1513"
] | Foscarnet | Prednisolone | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
789,
24,
891
]
],
[
[
789,
24,
175
],
[
175,
40,
891
]
],
[
[
789,
24,
167
],
[
167,
1,
891
]
],
[
[
789,
63,
218
],
[
218,
1,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Predniso... |
DB00446 | DB01157 | 597 | 304 | [
"DDInter351",
"DDInter1875"
] | Chloramphenicol | Trimetrexate | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Moderate | 1 | [
[
[
597,
24,
304
]
],
[
[
597,
21,
28703
],
[
28703,
60,
304
]
],
[
[
597,
63,
599
],
[
599,
24,
304
]
],
[
[
597,
24,
810
],
[
810,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimetrexate"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effec... | Chloramphenicol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Trimetrexate (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00213 | DB12825 | 837 | 1,375 | [
"DDInter1388",
"DDInter1032"
] | Pantoprazole | Lefamulin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
837,
24,
1375
]
],
[
[
837,
24,
159
],
[
159,
63,
1375
]
],
[
[
837,
24,
98
],
[
98,
24,
1375
]
],
[
[
837,
23,
1468
],
[
1468,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and... |
DB00317 | DB12130 | 883 | 1,017 | [
"DDInter810",
"DDInter1094"
] | Gefitinib | Lorlatinib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
883,
24,
1017
]
],
[
[
883,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
883,
24,
126
],
[
126,
24,
1017
]
],
[
[
883,
63,
529
],
[
529,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may... |
DB00959 | DB01319 | 1,486 | 34 | [
"DDInter1191",
"DDInter777"
] | Methylprednisolone | Fosamprenavir | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Major | 2 | [
[
[
1486,
25,
34
]
],
[
[
1486,
64,
1091
],
[
1091,
40,
34
]
],
[
[
1486,
6,
8374
],
[
8374,
45,
34
]
],
[
[
1486,
21,
28723
],
[
28723,
... | [
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Ampren... | Methylprednisolone may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Methylprednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Methylprednisolone (Compound) causes Malnutrition (Side Eff... |
DB04946 | DB09065 | 924 | 760 | [
"DDInter907",
"DDInter424"
] | Iloperidone | Cobicistat | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
924,
25,
760
]
],
[
[
924,
25,
1374
],
[
1374,
23,
760
]
],
[
[
924,
40,
1664
],
[
1664,
24,
760
]
],
[
[
924,
25,
868
],
[
868,
... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",
"{... | Iloperidone may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Iloperidone (Compound) resembles Risperidone (Compound) and Risperidone may cause a moderate interaction that could exacerbate... |
DB00842 | DB01075 | 686 | 1,376 | [
"DDInter1359",
"DDInter569"
] | Oxazepam | Diphenhydramine | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
686,
24,
1376
]
],
[
[
686,
24,
649
],
[
649,
63,
1376
]
],
[
[
686,
63,
128
],
[
128,
24,
1376
]
],
[
[
686,
24,
401
],
[
401,
... | [
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine a... |
DB00072 | DB08913 | 550 | 1,186 | [
"DDInter1846",
"DDInter1561"
] | Trastuzumab | Radium Ra 223 dichloride | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
550,
24,
1186
]
],
[
[
550,
25,
51
],
[
51,
24,
1186
]
],
[
[
550,
24,
1362
],
[
1362,
63,
1186
]
],
[
[
550,
24,
599
],
[
599,
... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daunorubicin"
],
[... | Trastuzumab may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Ola... |
DB00308 | DB00927 | 347 | 1,559 | [
"DDInter901",
"DDInter712"
] | Ibutilide | Famotidine | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
347,
24,
1559
]
],
[
[
347,
21,
28859
],
[
28859,
60,
1559
]
],
[
[
347,
24,
286
],
[
286,
62,
1559
]
],
[
[
347,
23,
112
],
[
112,
... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Atrioventricular block"
],
[
"Atrioventricular block",
"{... | Ibutilide (Compound) causes Atrioventricular block (Side Effect) and Atrioventricular block (Side Effect) is caused by Famotidine (Compound)
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit ... |
DB00280 | DB00398 | 494 | 79 | [
"DDInter575",
"DDInter1702"
] | Disopyramide | Sorafenib | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Major | 2 | [
[
[
494,
25,
79
]
],
[
[
494,
6,
8374
],
[
8374,
45,
79
]
],
[
[
494,
21,
29209
],
[
29209,
60,
79
]
],
[
[
494,
23,
112
],
[
112,
6... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sorafenib"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Sora... | Disopyramide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sorafenib (Compound)
Disopyramide (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Sorafenib (Compound)
Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and M... |
DB06605 | DB09280 | 1,409 | 1,604 | [
"DDInter108",
"DDInter1101"
] | Apixaban | Lumacaftor | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1409,
25,
1604
]
],
[
[
1409,
64,
1171
],
[
1171,
24,
1604
]
],
[
[
1409,
25,
292
],
[
292,
24,
1604
]
],
[
[
1409,
24,
1427
],
[
1427... | [
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meloxicam"
],
[
"Meloxicam",
"{u} may cau... | Apixaban may lead to a major life threatening interaction when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Apixaban may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may cause a moderate interact... |
DB00877 | DB04575 | 629 | 35 | [
"DDInter1678",
"DDInter1555"
] | Sirolimus | Quinestrol | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
629,
24,
35
]
],
[
[
629,
63,
566
],
[
566,
1,
35
]
],
[
[
629,
24,
984
],
[
984,
40,
35
]
],
[
[
629,
63,
1336
],
[
1336,
40,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Quinestrol (Compound)
... |
DB00687 | DB01263 | 870 | 859 | [
"DDInter747",
"DDInter1494"
] | Fludrocortisone | Posaconazole | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
870,
24,
859
]
],
[
[
870,
21,
28762
],
[
28762,
60,
859
]
],
[
[
870,
63,
1101
],
[
1101,
23,
859
]
],
[
[
870,
24,
286
],
[
286,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effec... | Fludrocortisone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with... |
DB00467 | DB00620 | 1,467 | 175 | [
"DDInter644",
"DDInter1855"
] | Enoxacin | Triamcinolone | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Major | 2 | [
[
[
1467,
25,
175
]
],
[
[
1467,
25,
1573
],
[
1573,
1,
175
]
],
[
[
1467,
64,
251
],
[
251,
1,
175
]
],
[
[
1467,
24,
115
],
[
115,
... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
]
],
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Prednisone",
"{u} (C... | Enoxacin may lead to a major life threatening interaction when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Enoxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone (Compound) resembles Triamcinolone (Compound)
Enoxacin may cause a m... |
DB00791 | DB11988 | 132 | 270 | [
"DDInter1902",
"DDInter1321"
] | Uracil mustard | Ocrelizumab | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
132,
24,
270
]
],
[
[
132,
63,
1461
],
[
1461,
23,
270
]
],
[
[
132,
24,
713
],
[
713,
24,
270
]
],
[
[
132,
24,
287
],
[
287,
6... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarat... |
DB00427 | DB01114 | 1,233 | 272 | [
"DDInter1879",
"DDInter362"
] | Triprolidine | Chlorpheniramine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1233,
24,
272
]
],
[
[
1233,
24,
358
],
[
358,
63,
272
]
],
[
[
1233,
1,
11268
],
[
11268,
1,
272
]
],
[
[
1233,
63,
128
],
[
128,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Triprolidine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Chlo... |
DB01118 | DB01169 | 33 | 57 | [
"DDInter76",
"DDInter120"
] | Amiodarone | Arsenic trioxide | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
33,
25,
57
]
],
[
[
33,
6,
8374
],
[
8374,
45,
57
]
],
[
[
33,
63,
112
],
[
112,
23,
57
]
],
[
[
33,
24,
603
],
[
603,
63,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"A... | Amiodarone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Am... |
DB00358 | DB00363 | 1,010 | 695 | [
"DDInter1140",
"DDInter419"
] | Mefloquine | Clozapine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
1010,
25,
695
]
],
[
[
1010,
24,
1178
],
[
1178,
1,
695
]
],
[
[
1010,
63,
902
],
[
902,
40,
695
]
],
[
[
1010,
24,
623
],
[
623,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
"Triflu... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Clozapine (Compou... |
DB00620 | DB08873 | 175 | 74 | [
"DDInter1855",
"DDInter221"
] | Triamcinolone | Boceprevir | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Major | 2 | [
[
[
175,
25,
74
]
],
[
[
175,
6,
8374
],
[
8374,
45,
74
]
],
[
[
175,
21,
28769
],
[
28769,
60,
74
]
],
[
[
175,
24,
473
],
[
473,
2... | [
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Boceprevir"
]
],
[
[
"Triamcinolone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"B... | Triamcinolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Triamcinolone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Boceprevir (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00564 | DB01254 | 1,236 | 1,213 | [
"DDInter293",
"DDInter484"
] | Carbamazepine | Dasatinib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1236,
25,
1213
]
],
[
[
1236,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1236,
18,
10375
],
[
10375,
57,
1213
]
],
[
[
1236,
21,
28882
],
[
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasa... | Carbamazepine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Carbamazepine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dasatinib (Compound)
Carbamazepine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effe... |
DB06176 | DB10315 | 1,342 | 1,137 | [
"DDInter1616",
"DDInter1127"
] | Romidepsin | Measles virus vaccine live attenuated | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1342,
25,
1137
]
],
[
[
1342,
64,
581
],
[
581,
25,
1137
]
],
[
[
1342,
24,
384
],
[
384,
25,
1137
]
],
[
[
1342,
63,
1184
],
[
1184,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Romidepsin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB00831 | DB08824 | 1,178 | 591 | [
"DDInter1866",
"DDInter959"
] | Trifluoperazine | Ioflupane I-123 | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
1178,
24,
591
]
],
[
[
1178,
21,
28722
],
[
28722,
60,
591
]
],
[
[
1178,
1,
684
],
[
684,
24,
591
]
],
[
[
1178,
40,
1630
],
[
1630,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect... | Trifluoperazine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Trifluoperazine (Compound) resembles Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Trifluoperazine (Compound)... |
DB12141 | DB13139 | 971 | 1,032 | [
"DDInter817",
"DDInter1063"
] | Gilteritinib | Levosalbutamol | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
971,
24,
1032
]
],
[
[
971,
63,
1220
],
[
1220,
23,
1032
]
],
[
[
971,
64,
1618
],
[
1618,
24,
1032
]
],
[
[
971,
63,
124
],
[
124,
... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Gilteritinib may lead to a major life threatening interaction when taken with Cabozantinib and Cabozan... |
DB00470 | DB00876 | 530 | 1,414 | [
"DDInter601",
"DDInter658"
] | Dronabinol | Eprosartan | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
530,
24,
1414
]
],
[
[
530,
24,
240
],
[
240,
40,
1414
]
],
[
[
530,
6,
6017
],
[
6017,
45,
1414
]
],
[
[
530,
21,
28975
],
[
28975,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Dronabinol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Eprosartan (Compound)
Dronabinol (Compound) causes Tension (Side Effect) and Tension (Side E... |
DB00731 | DB01059 | 1,144 | 956 | [
"DDInter1269",
"DDInter1313"
] | Nateglinide | Norfloxacin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Major | 2 | [
[
[
1144,
25,
956
]
],
[
[
1144,
25,
872
],
[
872,
40,
956
]
],
[
[
1144,
64,
1176
],
[
1176,
1,
956
]
],
[
[
1144,
25,
1539
],
[
1539,
... | [
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norfloxacin"
]
],
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin",
... | Nateglinide may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Nateglinide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Nateglinide may le... |
DB01041 | DB04948 | 770 | 1,084 | [
"DDInter1789",
"DDInter1083"
] | Thalidomide | Lofexidine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
770,
24,
1084
]
],
[
[
770,
63,
1617
],
[
1617,
1,
1084
]
],
[
[
770,
63,
112
],
[
112,
23,
1084
]
],
[
[
770,
63,
618
],
[
618,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction... |
DB00350 | DB01235 | 1,214 | 1,191 | [
"DDInter1226",
"DDInter1054"
] | Minoxidil | Levodopa | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
1214,
24,
1191
]
],
[
[
1214,
24,
1264
],
[
1264,
23,
1191
]
],
[
[
1214,
24,
1376
],
[
1376,
24,
1191
]
],
[
[
1214,
24,
820
],
[
820... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"Do... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinical effects when taken with Levodopa
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydrami... |
DB00619 | DB01232 | 1,419 | 1,327 | [
"DDInter909",
"DDInter1640"
] | Imatinib | Saquinavir | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
1419,
24,
1327
]
],
[
[
1419,
63,
798
],
[
798,
40,
1327
]
],
[
[
1419,
24,
915
],
[
915,
40,
1327
]
],
[
[
1419,
6,
10215
],
[
10215,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
Imat... |
DB00065 | DB00446 | 581 | 597 | [
"DDInter923",
"DDInter351"
] | Infliximab | Chloramphenicol | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
581,
24,
597
]
],
[
[
581,
25,
1101
],
[
1101,
23,
597
]
],
[
[
581,
24,
1627
],
[
1627,
62,
597
]
],
[
[
581,
25,
450
],
[
450,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexar... | Infliximab may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may c... |
DB00238 | DB11730 | 188 | 351 | [
"DDInter1285",
"DDInter1588"
] | Nevirapine | Ribociclib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
188,
24,
351
]
],
[
[
188,
24,
466
],
[
466,
62,
351
]
],
[
[
188,
24,
222
],
[
222,
23,
351
]
],
[
[
188,
24,
310
],
[
310,
24,... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sib... |
DB00986 | DB01148 | 1,192 | 1,128 | [
"DDInter834",
"DDInter738"
] | Glycopyrronium | Flavoxate | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | Moderate | 1 | [
[
[
1192,
24,
1128
]
],
[
[
1192,
6,
7992
],
[
7992,
45,
1128
]
],
[
[
1192,
21,
29817
],
[
29817,
60,
1128
]
],
[
[
1192,
24,
537
],
[
53... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flavoxate"
]
],
[
[
"Glycopyrronium",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compou... | Glycopyrronium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Flavoxate (Compound)
Glycopyrronium (Compound) causes Hyperpyrexia (Side Effect) and Hyperpyrexia (Side Effect) is caused by Flavoxate (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Cycli... |
DB01344 | DB11348 | 1,231 | 1,065 | [
"DDInter1830",
"DDInter279"
] | Tolevamer | Calcium Phosphate | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
1231,
24,
1065
]
],
[
[
1231,
24,
624
],
[
624,
24,
1065
]
],
[
[
1231,
63,
1152
],
[
1152,
24,
1065
]
],
[
[
1231,
24,
624
],
[
624,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
[
... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Lioth... |
DB01041 | DB01619 | 770 | 830 | [
"DDInter1789",
"DDInter1441"
] | Thalidomide | Phenindamine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
770,
24,
830
]
],
[
[
770,
63,
1251
],
[
1251,
1,
830
]
],
[
[
770,
24,
537
],
[
537,
40,
830
]
],
[
[
770,
63,
1219
],
[
1219,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Mirtazapine and Mirtazapine (Compound) resembles Phenindamine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Comp... |
DB00454 | DB12130 | 1,349 | 1,017 | [
"DDInter1150",
"DDInter1094"
] | Meperidine | Lorlatinib | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1349,
24,
1017
]
],
[
[
1349,
24,
976
],
[
976,
24,
1017
]
],
[
[
1349,
24,
159
],
[
159,
63,
1017
]
],
[
[
1349,
25,
222
],
[
222,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[
... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and L... |
DB00026 | DB11817 | 1,184 | 1,259 | [
"DDInter94",
"DDInter165"
] | Anakinra | Baricitinib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1184,
25,
1259
]
],
[
[
1184,
23,
1193
],
[
1193,
23,
1259
]
],
[
[
1184,
24,
949
],
[
949,
24,
1259
]
],
[
[
1184,
24,
1129
],
[
1129... | [
[
[
"Anakinra",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc glucon... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani t... |
DB00342 | DB11110 | 1,181 | 603 | [
"DDInter1770",
"DDInter1115"
] | Terfenadine | Magnesium citrate | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1181,
24,
603
]
],
[
[
1181,
25,
57
],
[
57,
24,
603
]
],
[
[
1181,
24,
789
],
[
789,
24,
603
]
],
[
[
1181,
64,
494
],
[
494,
2... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Terfenadine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and F... |
DB00580 | DB09156 | 311 | 777 | [
"DDInter1910",
"DDInter964"
] | Valdecoxib | Iopromide | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
311,
25,
777
]
],
[
[
311,
24,
372
],
[
372,
25,
777
]
],
[
[
311,
63,
663
],
[
663,
25,
777
]
],
[
[
311,
25,
629
],
[
629,
25,... | [
[
[
"Valdecoxib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
"Clofarabin... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may lead to a major life threatening interaction when taken with Iopromide
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may l... |
DB00175 | DB11986 | 681 | 484 | [
"DDInter1509",
"DDInter648"
] | Pravastatin | Entrectinib | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
681,
24,
484
]
],
[
[
681,
24,
112
],
[
112,
23,
484
]
],
[
[
681,
24,
466
],
[
466,
62,
484
]
],
[
[
681,
24,
322
],
[
322,
24,... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide a... |
DB00712 | DB09030 | 1,274 | 840 | [
"DDInter763",
"DDInter1945"
] | Flurbiprofen | Vorapaxar | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
1274,
25,
840
]
],
[
[
1274,
23,
297
],
[
297,
62,
840
]
],
[
[
1274,
63,
1416
],
[
1416,
24,
840
]
],
[
[
1274,
24,
885
],
[
885,
... | [
[
[
"Flurbiprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Flurbiprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib and Rofecoxib may caus... |
DB01285 | DB11057 | 708 | 720 | [
"DDInter445",
"DDInter1223"
] | Corticotropin | Mineral oil | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
708,
24,
720
]
],
[
[
708,
63,
323
],
[
323,
24,
720
]
],
[
[
708,
24,
178
],
[
178,
24,
720
]
],
[
[
708,
64,
33
],
[
33,
24,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bendroflumethiazide"... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01114 | DB01192 | 272 | 560 | [
"DDInter362",
"DDInter1372"
] | Chlorpheniramine | Oxymorphone | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
272,
24,
560
]
],
[
[
272,
63,
828
],
[
828,
1,
560
]
],
[
[
272,
6,
12523
],
[
12523,
45,
560
]
],
[
[
272,
21,
28817
],
[
28817,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Chlorpheniramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxymorphone (Compound)
Chlorpheniramine (Compound) causes Vision blurred (Sid... |
DB00451 | DB01193 | 542 | 819 | [
"DDInter1064",
"DDInter12"
] | Levothyroxine | Acebutolol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Minor | 0 | [
[
[
542,
23,
819
]
],
[
[
542,
23,
887
],
[
887,
1,
819
]
],
[
[
542,
62,
88
],
[
88,
1,
819
]
],
[
[
542,
6,
4973
],
[
4973,
45,
... | [
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pindolol"
],
[
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol and Metoprolol (Compound) resembles Acebutolol (Compound)
Le... |
DB06441 | DB14357 | 936 | 944 | [
"DDInter283",
"DDInter347"
] | Cangrelor | Chamomile | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
936,
23,
944
]
],
[
[
936,
64,
256
],
[
256,
23,
944
]
],
[
[
936,
25,
498
],
[
498,
23,
944
]
],
[
[
936,
63,
1061
],
[
1061,
2... | [
[
[
"Cangrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Cangrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Cangrelor may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Cangrelor may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a minor interaction that c... |
DB00918 | DB01191 | 1,373 | 1,039 | [
"DDInter49",
"DDInter518"
] | Almotriptan | Dexfenfluramine | Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that ... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
1373,
25,
1039
]
],
[
[
1373,
6,
10215
],
[
10215,
45,
1039
]
],
[
[
1373,
24,
760
],
[
760,
63,
1039
]
],
[
[
1373,
63,
1419
],
[
141... | [
[
[
"Almotriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Almotriptan",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Almotriptan (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexfenfluramine (Compound)
Almotriptan may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Almo... |
DB00621 | DB01309 | 1,026 | 1,254 | [
"DDInter1357",
"DDInter933"
] | Oxandrolone | Insulin glulisine | A synthetic hormone with anabolic and androgenic properties. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1026,
24,
1254
]
],
[
[
1026,
24,
167
],
[
167,
24,
1254
]
],
[
[
1026,
63,
305
],
[
305,
24,
1254
]
],
[
[
1026,
24,
637
],
[
637,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
... | Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Aspa... |
DB09078 | DB12332 | 1,228 | 1,619 | [
"DDInter1036",
"DDInter1626"
] | Lenvatinib | Rucaparib | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1228,
24,
1619
]
],
[
[
1228,
62,
112
],
[
112,
23,
1619
]
],
[
[
1228,
63,
87
],
[
87,
24,
1619
]
],
[
[
1228,
24,
1662
],
[
1662,
... | [
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Lenvatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Lenvatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxap... |
DB00022 | DB12834 | 268 | 148 | [
"DDInter1408",
"DDInter1649"
] | Peginterferon alfa-2b | Secnidazole | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
268,
24,
148
]
],
[
[
268,
24,
1593
],
[
1593,
24,
148
]
],
[
[
268,
63,
491
],
[
491,
24,
148
]
],
[
[
268,
25,
1477
],
[
1477,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Criz... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00421 | DB00635 | 443 | 1,573 | [
"DDInter1707",
"DDInter1515"
] | Spironolactone | Prednisone | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
443,
24,
1573
]
],
[
[
443,
24,
175
],
[
175,
40,
1573
]
],
[
[
443,
1,
11347
],
[
11347,
40,
1573
]
],
[
[
443,
1,
1581
],
[
1581,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Spironolactone (Compound) resembles Hydrocortamate (Compound) and Hydrocortamate (Compound) resembles Prednisone (Compound)
Spironolactone (Compound) ... |
DB00694 | DB09268 | 51 | 1,662 | [
"DDInter485",
"DDInter1464"
] | Daunorubicin | Picosulfuric acid | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
51,
24,
1662
]
],
[
[
51,
24,
1164
],
[
1164,
24,
1662
]
],
[
[
51,
24,
484
],
[
484,
63,
1662
]
],
[
[
51,
25,
1618
],
[
1618,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Entrec... |
DB00099 | DB06595 | 440 | 1,491 | [
"DDInter735",
"DDInter1214"
] | Filgrastim | Midostaurin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
440,
24,
1491
]
],
[
[
440,
24,
1342
],
[
1342,
24,
1491
]
],
[
[
440,
24,
1399
],
[
1399,
63,
1491
]
],
[
[
440,
63,
599
],
[
599,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate an... |
DB00361 | DB08827 | 134 | 990 | [
"DDInter1939",
"DDInter1085"
] | Vinorelbine | Lomitapide | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
134,
24,
990
]
],
[
[
134,
25,
1080
],
[
1080,
1,
990
]
],
[
[
134,
6,
8374
],
[
8374,
45,
990
]
],
[
[
134,
21,
28701
],
[
28701,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivapt... | Vinorelbine may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Vinorelbine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Eff... |
DB01267 | DB09488 | 519 | 103 | [
"DDInter1381",
"DDInter23"
] | Paliperidone | Acrivastine | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
519,
24,
103
]
],
[
[
519,
63,
85
],
[
85,
24,
103
]
],
[
[
519,
24,
830
],
[
830,
24,
103
]
],
[
[
519,
40,
1664
],
[
1664,
24,... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phe... |
DB00176 | DB00470 | 529 | 530 | [
"DDInter770",
"DDInter601"
] | Fluvoxamine | Dronabinol | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
529,
24,
530
]
],
[
[
529,
24,
1614
],
[
1614,
40,
530
]
],
[
[
529,
6,
6017
],
[
6017,
45,
530
]
],
[
[
529,
21,
29226
],
[
29226,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Fluvoxamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dronabinol (Compound)
Fluvoxamine (Compound) causes Sinusitis (Side Effect) and Sinusitis ... |
DB00580 | DB01259 | 311 | 392 | [
"DDInter1910",
"DDInter1024"
] | Valdecoxib | Lapatinib | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
311,
24,
392
]
],
[
[
311,
24,
112
],
[
112,
23,
392
]
],
[
[
311,
63,
254
],
[
254,
24,
392
]
],
[
[
311,
24,
167
],
[
167,
24,... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lapatinib
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and Nit... |
DB00928 | DB01041 | 1,426 | 770 | [
"DDInter148",
"DDInter1789"
] | Azacitidine | Thalidomide | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
1426,
25,
770
]
],
[
[
1426,
7,
7720
],
[
7720,
45,
770
]
],
[
[
1426,
18,
5051
],
[
5051,
46,
770
]
],
[
[
1426,
7,
7669
],
[
7669,
... | [
[
[
"Azacitidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Azacitidine",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compound)",
"... | Azacitidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Thalidomide (Compound)
Azacitidine (Compound) downregulates SMARCD2 (Gene) and SMARCD2 (Gene) is upregulated by Thalidomide (Compound)
Azacitidine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Az... |
DB01001 | DB01599 | 688 | 1,232 | [
"DDInter1632",
"DDInter1523"
] | Salbutamol | Probucol | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
688,
24,
1232
]
],
[
[
688,
62,
112
],
[
112,
23,
1232
]
],
[
[
688,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
688,
24,
927
],
[
927,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxali... |
DB00029 | DB06081 | 25 | 1,046 | [
"DDInter99",
"DDInter286"
] | Anistreplase | Caplacizumab | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Major | 2 | [
[
[
25,
25,
1046
]
],
[
[
25,
23,
1631
],
[
1631,
62,
1046
]
],
[
[
25,
24,
222
],
[
222,
24,
1046
]
],
[
[
25,
24,
1427
],
[
1427,
... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Caplacizumab
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutra... |
DB11986 | DB15982 | 484 | 1,339 | [
"DDInter648",
"DDInter193"
] | Entrectinib | Berotralstat | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
484,
25,
1339
]
],
[
[
484,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
484,
62,
222
],
[
222,
23,
1339
]
],
[
[
484,
25,
283
],
[
283,
... | [
[
[
"Entrectinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Entrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Entrectinib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibut... |
DB00047 | DB00903 | 176 | 1,680 | [
"DDInter932",
"DDInter686"
] | Insulin glargine | Etacrynic acid | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Moderate | 1 | [
[
[
176,
24,
1680
]
],
[
[
176,
24,
1545
],
[
1545,
23,
1680
]
],
[
[
176,
24,
1669
],
[
1669,
62,
1680
]
],
[
[
176,
24,
1021
],
[
1021,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxytetracyc... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Etacrynic acid
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00188 | DB00357 | 168 | 1,051 | [
"DDInter222",
"DDInter71"
] | Bortezomib | Aminoglutethimide | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Minor | 0 | [
[
[
168,
23,
1051
]
],
[
[
168,
6,
8374
],
[
8374,
45,
1051
]
],
[
[
168,
33,
5795
],
[
5795,
57,
1051
]
],
[
[
168,
21,
28803
],
[
28803,... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aminoglutethimide"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Bortezomib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aminoglutethimide (Compound)
Bortezomib (Compound) binds PSMB8 (Gene) and Bortezomib (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is downregulated by Aminoglutethimide (Compound)
Bortezomib (Compound) causes Anaemia (Side Effect) and Anae... |
DB00041 | DB08870 | 1,648 | 850 | [
"DDInter38",
"DDInter228"
] | Aldesleukin | Brentuximab vedotin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1648,
24,
850
]
],
[
[
1648,
24,
496
],
[
496,
63,
850
]
],
[
[
1648,
25,
611
],
[
611,
24,
850
]
],
[
[
1648,
24,
896
],
[
896,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vacc... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Aldesleukin may lead to a major life threatening interaction when taken with Dacarba... |
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