drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00502 | DB01176 | 1,300 | 537 | [
"DDInter853",
"DDInter453"
] | Haloperidol | Cyclizine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1300,
24,
537
]
],
[
[
1300,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1300,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1300,
24,
104
],
[
104,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cet... |
DB08916 | DB09065 | 26 | 760 | [
"DDInter32",
"DDInter424"
] | Afatinib | Cobicistat | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
26,
24,
760
]
],
[
[
26,
24,
1627
],
[
1627,
23,
760
]
],
[
[
26,
63,
1374
],
[
1374,
23,
760
]
],
[
[
26,
24,
938
],
[
938,
63,... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiratero... |
DB00881 | DB01142 | 954 | 1,264 | [
"DDInter1554",
"DDInter593"
] | Quinapril | Doxepin | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
954,
24,
1264
]
],
[
[
954,
24,
401
],
[
401,
24,
1264
]
],
[
[
954,
21,
28898
],
[
28898,
60,
1264
]
],
[
[
954,
63,
1648
],
[
1648,
... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Quinapril (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxepin (Comp... |
DB06274 | DB11581 | 574 | 1,456 | [
"DDInter59",
"DDInter1926"
] | Alvimopan | Venetoclax | Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
574,
24,
1456
]
],
[
[
574,
24,
214
],
[
214,
63,
1456
]
],
[
[
574,
24,
913
],
[
913,
64,
1456
]
],
[
[
574,
1,
215
],
[
215,
2... | [
[
[
"Alvimopan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Alvimopan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
... | Alvimopan may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Alvimopan may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apa... |
DB00532 | DB00544 | 208 | 970 | [
"DDInter1152",
"DDInter757"
] | Mephenytoin | Fluorouracil | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Moderate | 1 | [
[
[
208,
24,
970
]
],
[
[
208,
24,
147
],
[
147,
62,
970
]
],
[
[
208,
24,
1531
],
[
1531,
63,
970
]
],
[
[
208,
63,
482
],
[
482,
2... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Fluorouracil
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and C... |
DB01238 | DB11963 | 673 | 1,045 | [
"DDInter118",
"DDInter465"
] | Aripiprazole | Dacomitinib | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
673,
24,
1045
]
],
[
[
673,
63,
1039
],
[
1039,
24,
1045
]
],
[
[
673,
1,
827
],
[
827,
24,
1045
]
],
[
[
673,
24,
384
],
[
384,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Aripiprazole (Compound) resembles Trazodone (Compound) and Trazodone may cause a moderate interacti... |
DB00196 | DB11828 | 600 | 1,406 | [
"DDInter743",
"DDInter1281"
] | Fluconazole | Neratinib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
600,
25,
1406
]
],
[
[
600,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
600,
24,
392
],
[
392,
24,
1406
]
],
[
[
600,
25,
1510
],
[
1510,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ma... | Fluconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a mod... |
DB00501 | DB00705 | 752 | 441 | [
"DDInter380",
"DDInter496"
] | Cimetidine | Delavirdine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
752,
24,
441
]
],
[
[
752,
6,
21998
],
[
21998,
45,
441
]
],
[
[
752,
21,
29058
],
[
29058,
60,
441
]
],
[
[
752,
23,
466
],
[
466,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound ... | Cimetidine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Delavirdine (Compound)
Cimetidine (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Delavirdine (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with D... |
DB00312 | DB06626 | 1,023 | 263 | [
"DDInter1423",
"DDInter147"
] | Pentobarbital | Axitinib | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
1023,
24,
263
]
],
[
[
1023,
23,
752
],
[
752,
23,
263
]
],
[
[
1023,
24,
392
],
[
392,
24,
263
]
],
[
[
1023,
24,
1593
],
[
1593,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Pentobarbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],
[
... | Pentobarbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Axitinib
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatin... |
DB00808 | DB01070 | 1,605 | 1,098 | [
"DDInter916",
"DDInter558"
] | Indapamide | Dihydrotachysterol | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
1605,
24,
1098
]
],
[
[
1605,
63,
386
],
[
386,
25,
1098
]
],
[
[
1605,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
1605,
24,
603
],
[
603,
... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol and P... |
DB00877 | DB10429 | 629 | 200 | [
"DDInter1678",
"DDInter282"
] | Sirolimus | Candida albicans | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
629,
24,
200
]
],
[
[
629,
24,
1096
],
[
1096,
24,
200
]
],
[
[
629,
25,
976
],
[
976,
24,
200
]
],
[
[
629,
24,
1019
],
[
1019,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Sirolimus may lead to a major life threatening interaction when taken with Tofacitinib and To... |
DB00514 | DB00792 | 506 | 832 | [
"DDInter527",
"DDInter1878"
] | Dextromethorphan | Tripelennamine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
506,
24,
832
]
],
[
[
506,
24,
100
],
[
100,
63,
832
]
],
[
[
506,
24,
939
],
[
939,
1,
832
]
],
[
[
506,
63,
508
],
[
508,
1,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromphenira... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00586 | DB06441 | 1,512 | 936 | [
"DDInter537",
"DDInter283"
] | Diclofenac | Cangrelor | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
1512,
24,
936
]
],
[
[
1512,
23,
297
],
[
297,
62,
936
]
],
[
[
1512,
24,
97
],
[
97,
24,
936
]
],
[
[
1512,
24,
637
],
[
637,
6... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Diclofenac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clo... | Diclofenac may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin may cause a ... |
DB00775 | DB09068 | 1,226 | 1,427 | [
"DDInter1818",
"DDInter1948"
] | Tirofiban | Vortioxetine | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1226,
24,
1427
]
],
[
[
1226,
64,
25
],
[
25,
24,
1427
]
],
[
[
1226,
25,
256
],
[
256,
24,
1427
]
],
[
[
1226,
24,
477
],
[
477,
... | [
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"Anistrep... | Tirofiban may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Tirofiban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a moderate in... |
DB00488 | DB08826 | 196 | 1,292 | [
"DDInter57",
"DDInter489"
] | Altretamine | Deferiprone | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
196,
25,
1292
]
],
[
[
196,
21,
28722
],
[
28722,
60,
1292
]
],
[
[
196,
24,
4
],
[
4,
25,
1292
]
],
[
[
196,
64,
1064
],
[
1064,
... | [
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Altretamine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compoun... | Altretamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Deferiprone (Compound)
Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken ... |
DB00550 | DB01359 | 99 | 729 | [
"DDInter1541",
"DDInter1417"
] | Propylthiouracil | Penbutolol | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
99,
24,
729
]
],
[
[
99,
63,
461
],
[
461,
1,
729
]
],
[
[
99,
21,
28762
],
[
28762,
60,
729
]
],
[
[
99,
63,
542
],
[
542,
23,
... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],... | Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Propylthiouracil (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Penbutolol (Compound)
Propylthiouracil may cause a moderate in... |
DB00477 | DB11130 | 216 | 407 | [
"DDInter363",
"DDInter1344"
] | Chlorpromazine | Opium | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
216,
24,
407
]
],
[
[
216,
24,
662
],
[
662,
24,
407
]
],
[
[
216,
35,
104
],
[
104,
24,
407
]
],
[
[
216,
63,
1233
],
[
1233,
2... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Chlorpromazine (Compound) resembles Methdilazine (Compound) and Chlorpromazine may cause a moderate interac... |
DB00238 | DB00361 | 188 | 134 | [
"DDInter1285",
"DDInter1939"
] | Nevirapine | Vinorelbine | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
188,
24,
134
]
],
[
[
188,
24,
147
],
[
147,
63,
134
]
],
[
[
188,
6,
8374
],
[
8374,
45,
134
]
],
[
[
188,
21,
28658
],
[
28658,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinorelbine (Compound)
Nevirapine (Co... |
DB00991 | DB08890 | 97 | 16 | [
"DDInter1358",
"DDInter1069"
] | Oxaprozin | Linaclotide | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin deri... | Minor | 0 | [
[
[
97,
23,
16
]
],
[
[
97,
63,
1314
],
[
1314,
40,
16
]
],
[
[
97,
63,
1512
],
[
1512,
23,
16
]
],
[
[
97,
24,
848
],
[
848,
23,
... | [
[
[
"Oxaprozin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Linaclotide (Compound)
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a minor interaction that can l... |
DB00046 | DB00627 | 1,179 | 265 | [
"DDInter940",
"DDInter1286"
] | Insulin lispro | Niacin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
1179,
24,
265
]
],
[
[
1179,
24,
1479
],
[
1479,
62,
265
]
],
[
[
1179,
24,
245
],
[
245,
24,
265
]
],
[
[
1179,
24,
433
],
[
433,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Niacin
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01024 | DB08908 | 1,096 | 713 | [
"DDInter1252",
"DDInter564"
] | Mycophenolic acid | Dimethyl fumarate | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1096,
24,
713
]
],
[
[
1096,
24,
4
],
[
4,
24,
713
]
],
[
[
1096,
63,
453
],
[
453,
24,
713
]
],
[
[
1096,
24,
270
],
[
270,
63,... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacet... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Mycophenolic acid may cause a moderate interaction that could exacer... |
DB08870 | DB14783 | 850 | 287 | [
"DDInter228",
"DDInter574"
] | Brentuximab vedotin | Diroximel fumarate | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
850,
24,
287
]
],
[
[
850,
63,
1101
],
[
1101,
24,
287
]
],
[
[
850,
24,
384
],
[
384,
24,
287
]
],
[
[
850,
64,
329
],
[
329,
2... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"B... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00220 | DB00307 | 798 | 1,101 | [
"DDInter1276",
"DDInter202"
] | Nelfinavir | Bexarotene | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Moderate | 1 | [
[
[
798,
24,
1101
]
],
[
[
798,
6,
8374
],
[
8374,
45,
1101
]
],
[
[
798,
21,
28762
],
[
28762,
60,
1101
]
],
[
[
798,
24,
353
],
[
353,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Nelfinavir (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Gris... |
DB00404 | DB11569 | 523 | 1,093 | [
"DDInter54",
"DDInter1003"
] | Alprazolam | Ixekizumab | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
523,
24,
1093
]
],
[
[
523,
63,
608
],
[
608,
24,
1093
]
],
[
[
523,
24,
1683
],
[
1683,
24,
1093
]
],
[
[
523,
40,
1382
],
[
1382,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekin... |
DB00620 | DB14723 | 175 | 159 | [
"DDInter1855",
"DDInter1026"
] | Triamcinolone | Larotrectinib | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
175,
24,
159
]
],
[
[
175,
24,
1375
],
[
1375,
24,
159
]
],
[
[
175,
23,
307
],
[
307,
24,
159
]
],
[
[
175,
24,
1412
],
[
1412,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Triamcinolone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Mo... |
DB00586 | DB09122 | 1,512 | 1,613 | [
"DDInter537",
"DDInter1409"
] | Diclofenac | Peginterferon beta-1a | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1512,
24,
1613
]
],
[
[
1512,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
1512,
63,
152
],
[
152,
24,
1613
]
],
[
[
1512,
24,
1383
],
[
1383... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bosentan... |
DB00782 | DB08815 | 1,123 | 154 | [
"DDInter1535",
"DDInter1104"
] | Propantheline | Lurasidone | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
1123,
24,
154
]
],
[
[
1123,
21,
29118
],
[
29118,
60,
154
]
],
[
[
1123,
24,
100
],
[
100,
24,
154
]
],
[
[
1123,
63,
1233
],
[
1233,... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Propantheline",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effec... | Propantheline (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Lurasidone (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases whe... |
DB00615 | DB01234 | 690 | 1,220 | [
"DDInter1589",
"DDInter513"
] | Rifabutin | Dexamethasone | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
690,
24,
1220
]
],
[
[
690,
24,
870
],
[
870,
1,
1220
]
],
[
[
690,
24,
175
],
[
175,
40,
1220
]
],
[
[
690,
63,
251
],
[
251,
1... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexam... |
DB00696 | DB06764 | 826 | 1,090 | [
"DDInter665",
"DDInter1787"
] | Ergotamine | Tetryzoline (nasal) | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Major | 2 | [
[
[
826,
25,
1090
]
],
[
[
826,
25,
222
],
[
222,
24,
1090
]
],
[
[
826,
37,
247
],
[
247,
25,
1090
]
],
[
[
826,
40,
628
],
[
628,
... | [
[
[
"Ergotamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetryzoline"
]
],
[
[
"Ergotamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",
"{u... | Ergotamine may lead to a major life threatening interaction when taken with Tetryzoline
Ergotamine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Ergotamine may cause a moderate inte... |
DB00333 | DB09080 | 576 | 144 | [
"DDInter1166",
"DDInter1331"
] | Methadone | Olodaterol | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
576,
24,
144
]
],
[
[
576,
25,
1011
],
[
1011,
24,
144
]
],
[
[
576,
1,
1301
],
[
1301,
24,
144
]
],
[
[
576,
35,
543
],
[
543,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolimod",... | Methadone may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Methadone (Compound) resembles Levacetylmethadol (Compound) and Levacetylmethadol may cause a moderate interaction that could ex... |
DB00280 | DB00443 | 494 | 251 | [
"DDInter575",
"DDInter195"
] | Disopyramide | Betamethasone | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
494,
24,
251
]
],
[
[
494,
24,
617
],
[
617,
40,
251
]
],
[
[
494,
24,
870
],
[
870,
1,
251
]
],
[
[
494,
6,
8374
],
[
8374,
45,... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betam... |
DB01438 | DB09112 | 585 | 1,455 | [
"DDInter1438",
"DDInter1306"
] | Phenazopyridine | Nitrous acid | Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is still us... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
585,
25,
1455
]
],
[
[
585,
6,
3120
],
[
3120,
45,
285
],
[
285,
25,
1455
]
],
[
[
585,
6,
7953
],
[
7953,
45,
122
],
[
122,
24,
... | [
[
[
"Phenazopyridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Phenazopyridine",
"{u} (Compound) binds {v} (Gene)",
"SCN1A"
],
[
"SCN1A",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenazopyridine (Compound) binds SCN1A (Gene) and SCN1A (Gene) is bound by Articaine (Compound) and Articaine may lead to a major life threatening interaction when taken with Nitrous acid
Phenazopyridine (Compound) binds SCN5A (Gene) and SCN5A (Gene) is bound by Verapamil (Compound) and Verapamil may cause a moderate i... |
DB00222 | DB01241 | 245 | 1,206 | [
"DDInter825",
"DDInter812"
] | Glimepiride | Gemfibrozil | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Moderate | 1 | [
[
[
245,
24,
1206
]
],
[
[
245,
6,
6017
],
[
6017,
45,
1206
]
],
[
[
245,
21,
29232
],
[
29232,
60,
1206
]
],
[
[
245,
24,
1476
],
[
1476,... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemfibrozil"
]
],
[
[
"Glimepiride",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Gemfibrozil (Compound)
Glimepiride (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Gemfibrozil (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and... |
DB04574 | DB14723 | 177 | 159 | [
"DDInter684",
"DDInter1026"
] | Estrone sulfate (topical) | Larotrectinib | Estrone 3-sulfate is a steroid sulfate that is the 3-sulfate of estrone. It has a role as a human metabolite and a mouse metabolite. It is a 17-oxo steroid and a steroid sulfate. It is functionally related to an estrone. It is a conjugate acid of an estrone 3-sulfate(1-). It derives from a hydride of an estrane. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
177,
24,
159
]
],
[
[
177,
24,
98
],
[
98,
24,
159
]
],
[
[
177,
40,
35
],
[
35,
24,
159
]
],
[
[
177,
63,
1419
],
[
1419,
24,
... | [
[
[
"Estrone sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Estrone sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
... | Estrone sulfate may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Estrone sulfate may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectini... |
DB00916 | DB11915 | 112 | 1,293 | [
"DDInter1202",
"DDInter1909"
] | Metronidazole | Valbenazine | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Minor | 0 | [
[
[
112,
23,
1293
]
],
[
[
112,
62,
521
],
[
521,
24,
1293
]
],
[
[
112,
23,
401
],
[
401,
24,
1293
]
],
[
[
112,
23,
1619
],
[
1619,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Valbenazine"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Goserelin"
],
[
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Goserelin and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Promethazine and Pro... |
DB01168 | DB04835 | 1,053 | 1,655 | [
"DDInter1526",
"DDInter1125"
] | Procarbazine | Maraviroc | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
1053,
24,
1655
]
],
[
[
1053,
21,
29538
],
[
29538,
60,
1655
]
],
[
[
1053,
63,
1214
],
[
1214,
24,
1655
]
],
[
[
1053,
24,
885
],
[
8... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Procarbazine",
"{u} (Compound) causes {v} (Side Effect)",
"Herpes virus infection"
],
[
"Herpes virus infection",
... | Procarbazine (Compound) causes Herpes virus infection (Side Effect) and Herpes virus infection (Side Effect) is caused by Maraviroc (Compound)
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil and Minoxidil may cause a moderate interaction that could exacerbate disea... |
DB00850 | DB09481 | 1,630 | 460 | [
"DDInter1432",
"DDInter1113"
] | Perphenazine | Magnesium carbonate | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1630,
23,
460
]
],
[
[
1630,
35,
401
],
[
401,
23,
460
]
],
[
[
1630,
63,
999
],
[
999,
23,
460
]
],
[
[
1630,
1,
216
],
[
216,
... | [
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Perphenazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases w... | Perphenazine (Compound) resembles Promethazine (Compound) and Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Perphenazine may cause a moderate int... |
DB00533 | DB00631 | 1,416 | 372 | [
"DDInter1613",
"DDInter405"
] | Rofecoxib | Clofarabine | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1416,
24,
372
]
],
[
[
1416,
63,
1560
],
[
1560,
24,
372
]
],
[
[
1416,
24,
663
],
[
663,
24,
372
]
],
[
[
1416,
24,
1448
],
[
1448,
... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegaspargase"
],
[
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and M... |
DB00321 | DB04837 | 21 | 649 | [
"DDInter78",
"DDInter407"
] | Amitriptyline | Clofedanol | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
21,
24,
649
]
],
[
[
21,
35,
1376
],
[
1376,
24,
649
]
],
[
[
21,
1,
1405
],
[
1405,
24,
649
]
],
[
[
21,
1,
293
],
[
293,
40,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when t... | Amitriptyline (Compound) resembles Diphenhydramine (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Amitriptyline (Compound) resemble... |
DB00652 | DB01041 | 234 | 770 | [
"DDInter1421",
"DDInter1789"
] | Pentazocine | Thalidomide | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
234,
24,
770
]
],
[
[
234,
21,
28789
],
[
28789,
60,
770
]
],
[
[
234,
24,
849
],
[
849,
63,
770
]
],
[
[
234,
63,
1614
],
[
1614,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Pentazocine",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
... | Pentazocine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate disea... |
DB06210 | DB15328 | 72 | 829 | [
"DDInter631",
"DDInter1896"
] | Eltrombopag | Ubrogepant | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
72,
24,
829
]
],
[
[
72,
24,
1476
],
[
1476,
24,
829
]
],
[
[
72,
63,
392
],
[
392,
24,
829
]
],
[
[
72,
25,
412
],
[
412,
24,
... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapat... |
DB12455 | DB14520 | 933 | 1,229 | [
"DDInter1336",
"DDInter1785"
] | Omadacycline | Tetraferric tricitrate decahydrate | Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in ani... | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Moderate | 1 | [
[
[
933,
24,
1229
]
],
[
[
933,
63,
803
],
[
803,
24,
943
],
[
943,
24,
1229
]
],
[
[
933,
63,
900
],
[
900,
63,
945
],
[
945,
24,
... | [
[
[
"Omadacycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Omadacycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omadacycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium chloride and Calcium chloride may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline and Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00604 | DB00819 | 1,425 | 471 | [
"DDInter385",
"DDInter15"
] | Cisapride | Acetazolamide | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Major | 2 | [
[
[
1425,
25,
471
]
],
[
[
1425,
25,
997
],
[
997,
40,
471
]
],
[
[
1425,
6,
8374
],
[
8374,
45,
471
]
],
[
[
1425,
25,
1264
],
[
1264,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetazolamide"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methazolamide"
],
[
"Methazolamide",
... | Cisapride may lead to a major life threatening interaction when taken with Methazolamide and Methazolamide (Compound) resembles Acetazolamide (Compound)
Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Acetazolamide (Compound)
Cisapride may lead to a major life threatening interaction when taken w... |
DB01041 | DB08871 | 770 | 36 | [
"DDInter1789",
"DDInter666"
] | Thalidomide | Eribulin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
770,
24,
36
]
],
[
[
770,
63,
122
],
[
122,
23,
36
]
],
[
[
770,
24,
519
],
[
519,
24,
36
]
],
[
[
770,
24,
221
],
[
221,
63,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperi... |
DB11979 | DB12941 | 1,320 | 466 | [
"DDInter625",
"DDInter481"
] | Elagolix | Darolutamide | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1320,
24,
466
]
],
[
[
1320,
64,
1622
],
[
1622,
23,
466
]
],
[
[
1320,
63,
34
],
[
34,
23,
466
]
],
[
[
1320,
24,
484
],
[
484,
... | [
[
[
"Elagolix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Elagolix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Voriconazo... | Elagolix may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir may ... |
DB00877 | DB14568 | 629 | 982 | [
"DDInter1678",
"DDInter1000"
] | Sirolimus | Ivosidenib | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
629,
24,
982
]
],
[
[
629,
63,
1101
],
[
1101,
23,
982
]
],
[
[
629,
25,
976
],
[
976,
24,
982
]
],
[
[
629,
63,
1081
],
[
1081,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Sirolimus may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a ... |
DB00674 | DB00877 | 1,516 | 629 | [
"DDInter802",
"DDInter1678"
] | Galantamine | Sirolimus | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1516,
24,
629
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
629
]
],
[
[
1516,
7,
10365
],
[
10365,
46,
629
]
],
[
[
1516,
18,
15501
],
[
1550... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Galantamine (Compound) upregulates STK10 (Gene) and STK10 (Gene) is upregulated by Sirolimus (Compound)
Galantamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sirolimus (Compound)
Galantamine ... |
DB00197 | DB15093 | 1,324 | 1,654 | [
"DDInter1881",
"DDInter1698"
] | Troglitazone | Somapacitan | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1324,
24,
1654
]
],
[
[
1324,
23,
608
],
[
608,
23,
1654
]
],
[
[
1324,
63,
168
],
[
168,
23,
1654
]
],
[
[
1324,
24,
10
],
[
10,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezo... |
DB01001 | DB01246 | 688 | 820 | [
"DDInter1632",
"DDInter45"
] | Salbutamol | Alimemazine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
688,
24,
820
]
],
[
[
688,
24,
401
],
[
401,
24,
820
]
],
[
[
688,
63,
939
],
[
939,
24,
820
]
],
[
[
688,
63,
675
],
[
675,
25,... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine an... |
DB00705 | DB09098 | 441 | 98 | [
"DDInter496",
"DDInter1700"
] | Delavirdine | Somatrem | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
441,
24,
98
]
],
[
[
441,
63,
608
],
[
608,
23,
98
]
],
[
[
441,
25,
159
],
[
159,
63,
98
]
],
[
[
441,
64,
11
],
[
11,
24,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somatrem
Delavirdine may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may caus... |
DB01144 | DB09112 | 1,326 | 1,455 | [
"DDInter540",
"DDInter1306"
] | Diclofenamide | Nitrous acid | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1326,
24,
1455
]
],
[
[
1326,
1,
674
],
[
674,
24,
1455
]
],
[
[
1326,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
1326,
40,
504
],
[
504,
... | [
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Diclofenamide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiazide",
... | Diclofenamide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a m... |
DB00673 | DB00969 | 723 | 2 | [
"DDInter112",
"DDInter52"
] | Aprepitant | Alosetron | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Moderate | 1 | [
[
[
723,
24,
2
]
],
[
[
723,
6,
6017
],
[
6017,
45,
2
]
],
[
[
723,
21,
28883
],
[
28883,
60,
2
]
],
[
[
723,
25,
1362
],
[
1362,
63... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alosetron"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Aprepitant (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Alosetron (Compound)
Aprepitant (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Alosetron (Compound)
Aprepitant may lead to a major life threatening interaction when taken with Olaparib and Olaparib may ca... |
DB01232 | DB14568 | 1,327 | 982 | [
"DDInter1640",
"DDInter1000"
] | Saquinavir | Ivosidenib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1327,
25,
982
]
],
[
[
1327,
62,
112
],
[
112,
23,
982
]
],
[
[
1327,
63,
168
],
[
168,
23,
982
]
],
[
[
1327,
64,
608
],
[
608,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Saquinavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Saquinavir may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bort... |
DB00242 | DB06772 | 1,064 | 310 | [
"DDInter392",
"DDInter259"
] | Cladribine | Cabazitaxel | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Major | 2 | [
[
[
1064,
25,
310
]
],
[
[
1064,
25,
973
],
[
973,
24,
310
]
],
[
[
1064,
6,
17404
],
[
17404,
45,
310
]
],
[
[
1064,
21,
28894
],
[
28894... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
],
[
"Paclitaxel",
"{u} ... | Cladribine may lead to a major life threatening interaction when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Cabazitaxel (Compound)
Cladribine (Compound) causes Card... |
DB01254 | DB12674 | 1,213 | 975 | [
"DDInter484",
"DDInter1105"
] | Dasatinib | Lurbinectedin | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1213,
24,
975
]
],
[
[
1213,
24,
159
],
[
159,
63,
975
]
],
[
[
1213,
24,
98
],
[
98,
24,
975
]
],
[
[
1213,
63,
147
],
[
147,
2... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and S... |
DB00029 | DB00215 | 25 | 1,230 | [
"DDInter99",
"DDInter388"
] | Anistreplase | Citalopram | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Moderate | 1 | [
[
[
25,
24,
1230
]
],
[
[
25,
24,
318
],
[
318,
40,
1230
]
],
[
[
25,
25,
500
],
[
500,
63,
1230
]
],
[
[
25,
24,
885
],
[
885,
63,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
],
... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) resembles Citalopram (Compound)
Anistreplase may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacer... |
DB00916 | DB08880 | 112 | 1,510 | [
"DDInter1202",
"DDInter1771"
] | Metronidazole | Teriflunomide | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
112,
24,
1510
]
],
[
[
112,
23,
129
],
[
129,
63,
1510
]
],
[
[
112,
24,
505
],
[
505,
63,
1510
]
],
[
[
112,
63,
1144
],
[
1144,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enzalutamide"
],... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydr... |
DB00486 | DB00678 | 1,614 | 240 | [
"DDInter1253",
"DDInter1095"
] | Nabilone | Losartan | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Moderate | 1 | [
[
[
1614,
24,
240
]
],
[
[
1614,
24,
1414
],
[
1414,
1,
240
]
],
[
[
1614,
63,
217
],
[
217,
1,
240
]
],
[
[
1614,
24,
911
],
[
911,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
],
[
"E... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Eprosartan and Eprosartan (Compound) resembles Losartan (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Losartan (Compound)
Nabilone... |
DB09061 | DB11979 | 1,627 | 1,320 | [
"DDInter284",
"DDInter625"
] | Cannabidiol | Elagolix | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1627,
24,
1320
]
],
[
[
1627,
63,
168
],
[
168,
23,
1320
]
],
[
[
1627,
63,
79
],
[
79,
24,
1320
]
],
[
[
1627,
24,
913
],
[
913,
... | [
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib... |
DB08826 | DB12498 | 1,292 | 76 | [
"DDInter489",
"DDInter1238"
] | Deferiprone | Mogamulizumab | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
1292,
25,
76
]
],
[
[
1292,
24,
1193
],
[
1193,
23,
76
]
],
[
[
1292,
25,
384
],
[
384,
24,
76
]
],
[
[
1292,
64,
248
],
[
248,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[
"Z... | Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Deferiprone may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib... |
DB00682 | DB01296 | 126 | 605 | [
"DDInter1951",
"DDInter829"
] | Warfarin | Glucosamine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to nonsteroidal anti-inflammatory drugs treating the painful symptoms of OA... | Moderate | 1 | [
[
[
126,
24,
605
]
],
[
[
126,
6,
10215
],
[
10215,
45,
605
]
],
[
[
126,
6,
8374
],
[
8374,
45,
1224
],
[
1224,
40,
605
]
],
[
[
126,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glucosamine"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Warfarin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Glucosamine (Compound)
Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cytarabine (Compound) and Cytarabine (Compound) resembles Glucosamine (Compound)
Warfarin may lead to a major life threatening interaction when taken with ... |
DB00515 | DB10675 | 589 | 961 | [
"DDInter387",
"DDInter1065"
] | Cisplatin | Licorice | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Licorice allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
589,
24,
961
]
],
[
[
589,
24,
870
],
[
870,
24,
961
]
],
[
[
589,
63,
251
],
[
251,
24,
961
]
],
[
[
589,
24,
1019
],
[
1019,
6... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Licorice"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone a... |
DB00207 | DB11978 | 1,570 | 124 | [
"DDInter157",
"DDInter822"
] | Azithromycin | Glasdegib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1570,
24,
124
]
],
[
[
1570,
23,
1135
],
[
1135,
23,
124
]
],
[
[
1570,
24,
79
],
[
79,
24,
124
]
],
[
[
1570,
63,
521
],
[
521,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Azithromycin may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib ... |
DB00163 | DB01169 | 1,461 | 57 | [
"DDInter1943",
"DDInter120"
] | Vitamin E | Arsenic trioxide | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Moderate | 1 | [
[
[
1461,
24,
57
]
],
[
[
1461,
23,
167
],
[
167,
25,
57
]
],
[
[
1461,
24,
1342
],
[
1342,
64,
57
]
],
[
[
1461,
24,
51
],
[
51,
25... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrocortisone"
],
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Hydrocortisone and Hydrocortisone may lead to a major life threatening interaction when taken with Arsenic trioxide
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin ... |
DB00834 | DB12332 | 932 | 1,619 | [
"DDInter1215",
"DDInter1626"
] | Mifepristone | Rucaparib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
932,
25,
1619
]
],
[
[
932,
23,
112
],
[
112,
23,
1619
]
],
[
[
932,
25,
1135
],
[
1135,
23,
1619
]
],
[
[
932,
24,
309
],
[
309,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Mifepristone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Mifepristone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Mifepristone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cau... |
DB00208 | DB00465 | 1,018 | 886 | [
"DDInter1804",
"DDInter1010"
] | Ticlopidine | Ketorolac | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Moderate | 1 | [
[
[
1018,
24,
886
]
],
[
[
1018,
24,
24
],
[
24,
40,
886
]
],
[
[
1018,
18,
10375
],
[
10375,
57,
886
]
],
[
[
1018,
21,
29340
],
[
29340,... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
],
[
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin (Compound) resembles Ketorolac (Compound)
Ticlopidine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ketorolac (Compound)
Ticlopidine (Compound) causes Stevens-Johnson syndrome... |
DB08895 | DB12095 | 976 | 179 | [
"DDInter1825",
"DDInter1760"
] | Tofacitinib | Telotristat ethyl | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
976,
24,
179
]
],
[
[
976,
64,
310
],
[
310,
24,
179
]
],
[
[
976,
24,
214
],
[
214,
24,
179
]
],
[
[
976,
25,
1468
],
[
1468,
2... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"... | Tofacitinib may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamat... |
DB00357 | DB00673 | 1,051 | 723 | [
"DDInter71",
"DDInter112"
] | Aminoglutethimide | Aprepitant | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
1051,
24,
723
]
],
[
[
1051,
24,
875
],
[
875,
40,
723
]
],
[
[
1051,
6,
7950
],
[
7950,
45,
723
]
],
[
[
1051,
21,
29062
],
[
29062,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant and Fosaprepitant (Compound) resembles Aprepitant (Compound)
Aminoglutethimide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Aprepitant (Compound)
Aminoglutethimide (Compound) causes Neutropeni... |
DB01229 | DB01232 | 973 | 1,327 | [
"DDInter1378",
"DDInter1640"
] | Paclitaxel (protein-bound) | Saquinavir | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
973,
25,
1327
]
],
[
[
973,
64,
798
],
[
798,
40,
1327
]
],
[
[
973,
6,
10417
],
[
10417,
45,
1327
]
],
[
[
973,
21,
29198
],
[
29198,... | [
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",
"{u} (... | Paclitaxel may lead to a major life threatening interaction when taken with Saquinavir
Paclitaxel may lead to a major life threatening interaction when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Paclitaxel (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saquinavir (Compou... |
DB04855 | DB12130 | 540 | 1,017 | [
"DDInter602",
"DDInter1094"
] | Dronedarone | Lorlatinib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
540,
24,
1017
]
],
[
[
540,
63,
608
],
[
608,
23,
1017
]
],
[
[
540,
24,
976
],
[
976,
24,
1017
]
],
[
[
540,
25,
1421
],
[
1421,
... | [
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacit... |
DB09034 | DB09143 | 1,313 | 313 | [
"DDInter1733",
"DDInter1701"
] | Suvorexant | Sonidegib | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Moderate | 1 | [
[
[
1313,
24,
313
]
],
[
[
1313,
63,
478
],
[
478,
24,
313
]
],
[
[
1313,
24,
484
],
[
484,
63,
313
]
],
[
[
1313,
24,
951
],
[
951,
... | [
[
[
"Suvorexant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sonidegib"
]
],
[
[
"Suvorexant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Suvorexant may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sonidegib
Suvorexant may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrecti... |
DB09570 | DB11988 | 1,480 | 270 | [
"DDInter1002",
"DDInter1321"
] | Ixazomib | Ocrelizumab | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1480,
24,
270
]
],
[
[
1480,
63,
1461
],
[
1461,
23,
270
]
],
[
[
1480,
24,
1060
],
[
1060,
63,
270
]
],
[
[
1480,
63,
134
],
[
134,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfor... |
DB00443 | DB01059 | 251 | 956 | [
"DDInter195",
"DDInter1313"
] | Betamethasone | Norfloxacin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Major | 2 | [
[
[
251,
25,
956
]
],
[
[
251,
25,
872
],
[
872,
40,
956
]
],
[
[
251,
64,
1176
],
[
1176,
1,
956
]
],
[
[
251,
25,
1539
],
[
1539,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norfloxacin"
]
],
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin",
... | Betamethasone may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Betamethasone may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Betamethasone ... |
DB00697 | DB01233 | 876 | 1,311 | [
"DDInter1821",
"DDInter1197"
] | Tizanidine | Metoclopramide | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
876,
24,
1311
]
],
[
[
876,
24,
1151
],
[
1151,
40,
1311
]
],
[
[
876,
64,
1425
],
[
1425,
40,
1311
]
],
[
[
876,
10,
11610
],
[
11610... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Tizanidine may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Tizanidine ... |
DB00035 | DB01209 | 1,314 | 1,359 | [
"DDInter507",
"DDInter531"
] | Desmopressin | Dezocine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1314,
24,
1359
]
],
[
[
1314,
24,
234
],
[
234,
1,
1359
]
],
[
[
1314,
24,
1264
],
[
1264,
24,
1359
]
],
[
[
1314,
24,
407
],
[
407,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could e... |
DB00978 | DB14520 | 739 | 1,229 | [
"DDInter1084",
"DDInter1785"
] | Lomefloxacin | Tetraferric tricitrate decahydrate | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Moderate | 1 | [
[
[
739,
24,
1229
]
],
[
[
739,
24,
1096
],
[
1096,
23,
1229
]
],
[
[
739,
1,
246
],
[
246,
24,
1229
]
],
[
[
739,
40,
1299
],
[
1299,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Tetraferric tricitrate decahydrate
Lomefloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin... |
DB00619 | DB08880 | 1,419 | 1,510 | [
"DDInter909",
"DDInter1771"
] | Imatinib | Teriflunomide | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1419,
25,
1510
]
],
[
[
1419,
63,
608
],
[
608,
23,
1510
]
],
[
[
1419,
25,
129
],
[
129,
63,
1510
]
],
[
[
1419,
24,
1033
],
[
1033,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Imatinib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a... |
DB00619 | DB14575 | 1,419 | 733 | [
"DDInter909",
"DDInter674"
] | Imatinib | Eslicarbazepine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1419,
24,
733
]
],
[
[
1419,
62,
1101
],
[
1101,
23,
733
]
],
[
[
1419,
24,
1264
],
[
1264,
24,
733
]
],
[
[
1419,
23,
222
],
[
222,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may ... |
DB00910 | DB09054 | 1,041 | 384 | [
"DDInter1394",
"DDInter905"
] | Paricalcitol | Idelalisib | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1041,
24,
384
]
],
[
[
1041,
25,
241
],
[
241,
63,
384
]
],
[
[
1041,
63,
1023
],
[
1023,
24,
384
]
],
[
[
1041,
24,
851
],
[
851,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Paricalcitol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erdafitinib"
],
[
"Erdaf... | Paricalcitol may lead to a major life threatening interaction when taken with Erdafitinib and Erdafitinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbita... |
DB01118 | DB09570 | 33 | 1,480 | [
"DDInter76",
"DDInter1002"
] | Amiodarone | Ixazomib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
33,
24,
1480
]
],
[
[
33,
63,
268
],
[
268,
24,
1480
]
],
[
[
33,
24,
148
],
[
148,
63,
1480
]
],
[
[
33,
24,
98
],
[
98,
24,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB00060 | DB09079 | 912 | 1,496 | [
"DDInter947",
"DDInter1296"
] | Interferon beta-1a | Nintedanib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
912,
24,
1496
]
],
[
[
912,
24,
33
],
[
33,
24,
1496
]
],
[
[
912,
24,
1412
],
[
1412,
63,
1496
]
],
[
[
912,
63,
305
],
[
305,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Calas... |
DB00005 | DB11989 | 1,057 | 1,434 | [
"DDInter687",
"DDInter183"
] | Etanercept | Benznidazole | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1057,
24,
1434
]
],
[
[
1057,
24,
788
],
[
788,
24,
1434
]
],
[
[
1057,
25,
375
],
[
375,
24,
1434
]
],
[
[
1057,
24,
148
],
[
148,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Etanercept may lead to a major life threatening interaction when taken with Certolizumab pegol and Certoli... |
DB00399 | DB01249 | 963 | 258 | [
"DDInter1968",
"DDInter958"
] | Zoledronic acid | Iodixanol | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
963,
25,
258
]
],
[
[
963,
25,
497
],
[
497,
1,
258
]
],
[
[
963,
21,
28748
],
[
28748,
60,
258
]
],
[
[
963,
24,
712
],
[
712,
... | [
[
[
"Zoledronic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Zoledronic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u... | Zoledronic acid may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Zoledronic acid (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Zoledronic acid may cause a moderate interaction that could e... |
DB00835 | DB01114 | 100 | 272 | [
"DDInter245",
"DDInter362"
] | Brompheniramine | Chlorpheniramine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
100,
35,
272
]
],
[
[
100,
35,
358
],
[
358,
63,
272
]
],
[
[
100,
1,
11775
],
[
11775,
40,
272
]
],
[
[
100,
24,
1237
],
[
1237,
... | [
[
[
"Brompheniramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Brompheniramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a mode... | Brompheniramine (Compound) resembles Chlorpheniramine (Compound) and
Brompheniramine (Compound) resembles Orphenadrine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate disea... |
DB00451 | DB00668 | 542 | 874 | [
"DDInter1064",
"DDInter652"
] | Levothyroxine | Epinephrine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
542,
24,
874
]
],
[
[
542,
63,
1636
],
[
1636,
1,
874
]
],
[
[
542,
24,
584
],
[
584,
1,
874
]
],
[
[
542,
6,
8374
],
[
8374,
45... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
]... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin and Levonordefrin (Compound) resembles Epi... |
DB00603 | DB01309 | 303 | 1,254 | [
"DDInter1137",
"DDInter933"
] | Medroxyprogesterone acetate | Insulin glulisine | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
303,
24,
1254
]
],
[
[
303,
40,
167
],
[
167,
24,
1254
]
],
[
[
303,
24,
1094
],
[
1094,
63,
1254
]
],
[
[
303,
63,
1645
],
[
1645,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) resembles {v} (Compound)",
"Hydrocortisone"
],
[
... | Medroxyprogesterone acetate (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metr... |
DB06595 | DB14783 | 1,491 | 287 | [
"DDInter1214",
"DDInter574"
] | Midostaurin | Diroximel fumarate | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1491,
24,
287
]
],
[
[
1491,
63,
1101
],
[
1101,
24,
287
]
],
[
[
1491,
25,
384
],
[
384,
24,
287
]
],
[
[
1491,
24,
1619
],
[
1619,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Midostaurin may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib ... |
DB00054 | DB00749 | 1,432 | 59 | [
"DDInter6",
"DDInter699"
] | Abciximab | Etodolac | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
1432,
24,
59
]
],
[
[
1432,
64,
25
],
[
25,
24,
59
]
],
[
[
1432,
25,
1018
],
[
1018,
24,
59
]
],
[
[
1432,
24,
1039
],
[
1039,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"Anistreplase... | Abciximab may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Abciximab may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine may cause a moderate in... |
DB01082 | DB01212 | 1,448 | 1,453 | [
"DDInter1713",
"DDInter334"
] | Streptomycin | Ceftriaxone | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse ac... | Moderate | 1 | [
[
[
1448,
24,
1453
]
],
[
[
1448,
24,
1024
],
[
1024,
40,
1453
]
],
[
[
1448,
63,
149
],
[
149,
40,
1453
]
],
[
[
1448,
24,
1227
],
[
1227... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftriaxone"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
],
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefpodoxime and Cefpodoxime (Compound) resembles Ceftriaxone (Compound)
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Ceftriaxone (... |
DB01088 | DB03619 | 714 | 557 | [
"DDInter908",
"DDInter501"
] | Iloprost | Deoxycholic acid | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Moderate | 1 | [
[
[
714,
24,
557
]
],
[
[
714,
63,
1479
],
[
1479,
24,
557
]
],
[
[
714,
25,
405
],
[
405,
63,
557
]
],
[
[
714,
25,
500
],
[
500,
2... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid
Iloprost may lead to a major life threatening interaction when taken with Acalabrutinib ... |
DB00005 | DB00393 | 1,057 | 854 | [
"DDInter687",
"DDInter1295"
] | Etanercept | Nimodipine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Moderate | 1 | [
[
[
1057,
24,
854
]
],
[
[
1057,
24,
84
],
[
84,
40,
854
]
],
[
[
1057,
25,
478
],
[
478,
63,
854
]
],
[
[
1057,
25,
1101
],
[
1101,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nimodipine"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nisoldipine"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Nisoldipine and Nisoldipine (Compound) resembles Nimodipine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate dis... |
DB00526 | DB00604 | 1,555 | 1,425 | [
"DDInter1355",
"DDInter385"
] | Oxaliplatin | Cisapride | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Major | 2 | [
[
[
1555,
25,
1425
]
],
[
[
1555,
25,
924
],
[
924,
64,
1425
]
],
[
[
1555,
6,
7950
],
[
7950,
45,
1425
]
],
[
[
1555,
23,
1247
],
[
1247,... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
]
],
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
],
[
"Iloperidone",
"{u... | Oxaliplatin may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone may lead to a major life threatening interaction when taken with Cisapride
Oxaliplatin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cisapride (Compound)
Oxaliplatin may cause a minor interaction that... |
DB00861 | DB09420 | 914 | 1,074 | [
"DDInter551",
"DDInter953"
] | Diflunisal | Iodide I-123 | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
914,
24,
1074
]
],
[
[
914,
25,
500
],
[
500,
24,
1074
]
],
[
[
914,
64,
126
],
[
126,
24,
1074
]
],
[
[
914,
63,
50
],
[
50,
24... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
"Enoxapar... | Diflunisal may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Diflunisal may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate intera... |
DB00603 | DB00872 | 303 | 1,080 | [
"DDInter1137",
"DDInter438"
] | Medroxyprogesterone acetate | Conivaptan | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Moderate | 1 | [
[
[
303,
24,
1080
]
],
[
[
303,
23,
700
],
[
700,
40,
1080
]
],
[
[
303,
6,
8374
],
[
8374,
45,
1080
]
],
[
[
303,
21,
28769
],
[
28769,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
... | Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Atorvastatin and Atorvastatin (Compound) resembles Conivaptan (Compound)
Medroxyprogesterone acetate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Conivaptan (Compound)
Medroxyprogesterone acetate (C... |
DB00748 | DB09034 | 662 | 1,313 | [
"DDInter297",
"DDInter1733"
] | Carbinoxamine | Suvorexant | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
662,
24,
1313
]
],
[
[
662,
35,
649
],
[
649,
24,
1313
]
],
[
[
662,
63,
530
],
[
530,
24,
1313
]
],
[
[
662,
24,
401
],
[
401,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when t... | Carbinoxamine (Compound) resembles Clofedanol (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Suvorexant
Carbinoxamine may cause a moderate interaction t... |
DB00434 | DB01191 | 13 | 1,039 | [
"DDInter459",
"DDInter518"
] | Cyproheptadine | Dexfenfluramine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
13,
24,
1039
]
],
[
[
13,
6,
5744
],
[
5744,
45,
1039
]
],
[
[
13,
24,
211
],
[
211,
23,
1039
]
],
[
[
13,
24,
673
],
[
673,
63,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"HTR2C"
],
[
"HTR2C",
"{u} (Gene) is bound by {v} (... | Cyproheptadine (Compound) binds HTR2C (Gene) and HTR2C (Gene) is bound by Dexfenfluramine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Dexfenfluramine
Cy... |
DB00405 | DB01043 | 128 | 108 | [
"DDInter517",
"DDInter1146"
] | Dexbrompheniramine | Memantine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in ... | Moderate | 1 | [
[
[
128,
24,
108
]
],
[
[
128,
24,
506
],
[
506,
23,
108
]
],
[
[
128,
24,
1264
],
[
1264,
63,
108
]
],
[
[
128,
24,
1219
],
[
1219,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Memantine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethor... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a minor interaction that can limit clinical effects when taken with Memantine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00562 | DB11130 | 1,014 | 407 | [
"DDInter188",
"DDInter1344"
] | Benzthiazide | Opium | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1014,
24,
407
]
],
[
[
1014,
24,
849
],
[
849,
24,
407
]
],
[
[
1014,
40,
178
],
[
178,
24,
407
]
],
[
[
1014,
1,
323
],
[
323,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Benzthiazide (Compound) resembles Polythiazide (Compound) and Polythiazide may cause a moderate interaction that co... |
DB00366 | DB00765 | 1,594 | 1,266 | [
"DDInter600",
"DDInter1205"
] | Doxylamine | Metyrosine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Moderate | 1 | [
[
[
1594,
24,
1266
]
],
[
[
1594,
21,
28779
],
[
28779,
60,
1266
]
],
[
[
1594,
24,
662
],
[
662,
24,
1266
]
],
[
[
1594,
24,
401
],
[
401... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metyrosine"
]
],
[
[
"Doxylamine",
"{u} (Compound) causes {v} (Side Effect)",
"Dry mouth"
],
[
"Dry mouth",
"{u} (Side Effect) is caus... | Doxylamine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Metyrosine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB05528 | DB06777 | 1,070 | 780 | [
"DDInter1228",
"DDInter348"
] | Mipomersen | Chenodeoxycholic acid | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Major | 2 | [
[
[
1070,
25,
780
]
],
[
[
1070,
25,
384
],
[
384,
63,
780
]
],
[
[
1070,
64,
267
],
[
267,
24,
780
]
],
[
[
1070,
25,
1510
],
[
1510,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chenodeoxycholic acid"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
[
"Idelalisib",
... | Mipomersen may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Chenodeoxycholic acid
Mipomersen may lead to a major life threatening interaction when taken with Naltrexone and Naltrexone may cause a mo... |
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