drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00743 | DB01229 | 808 | 973 | [
"DDInter792",
"DDInter1377"
] | Gadobenic acid | Paclitaxel | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
808,
24,
973
]
],
[
[
808,
21,
29267
],
[
29267,
60,
973
]
],
[
[
808,
63,
134
],
[
134,
24,
973
]
],
[
[
808,
24,
772
],
[
772,
... | [
[
[
"Gadobenic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Gadobenic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Alanine aminotransferase increased"
],
[
"Alanine ami... | Gadobenic acid (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Paclitaxel (Compound)
Gadobenic acid may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate intera... |
DB00476 | DB01001 | 109 | 688 | [
"DDInter608",
"DDInter1632"
] | Duloxetine | Salbutamol | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
109,
24,
688
]
],
[
[
109,
24,
874
],
[
874,
24,
688
]
],
[
[
109,
63,
1636
],
[
1636,
24,
688
]
],
[
[
109,
24,
1148
],
[
1148,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and P... |
DB00557 | DB14740 | 252 | 771 | [
"DDInter895",
"DDInter881"
] | Hydroxyzine | Hyaluronidase | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
252,
23,
771
]
],
[
[
252,
24,
849
],
[
849,
23,
771
]
],
[
[
252,
74,
1242
],
[
1242,
23,
771
]
],
[
[
252,
63,
1181
],
[
1181,
... | [
[
[
"Hydroxyzine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Hydroxyzine (Compound) resembles Cetirizine (Compound) and Hydroxyzine may cause a moderate interaction that c... |
DB00422 | DB01142 | 895 | 1,264 | [
"DDInter1189",
"DDInter593"
] | Methylphenidate | Doxepin | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
895,
24,
1264
]
],
[
[
895,
24,
401
],
[
401,
24,
1264
]
],
[
[
895,
6,
7390
],
[
7390,
45,
1264
]
],
[
[
895,
21,
29226
],
[
29226,
... | [
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Methylphenidate (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Doxepin (Compound)
Methylphen... |
DB00227 | DB00773 | 1,463 | 896 | [
"DDInter1098",
"DDInter702"
] | Lovastatin | Etoposide | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
1463,
24,
896
]
],
[
[
1463,
6,
5912
],
[
5912,
45,
896
]
],
[
[
1463,
18,
7335
],
[
7335,
46,
896
]
],
[
[
1463,
7,
12648
],
[
12648,... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Lovastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",
... | Lovastatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Etoposide (Compound)
Lovastatin (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is upregulated by Etoposide (Compound)
Lovastatin (Compound) upregulates GPER1 (Gene) and GPER1 (Gene) is upregulated by Etoposide (Compound)
Lovastatin (Compound) d... |
DB04948 | DB11110 | 1,084 | 603 | [
"DDInter1083",
"DDInter1115"
] | Lofexidine | Magnesium citrate | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1084,
24,
603
]
],
[
[
1084,
64,
57
],
[
57,
24,
603
]
],
[
[
1084,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1084,
63,
1151
],
[
1151,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Lofexidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Lofexidine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and His... |
DB00092 | DB09052 | 58 | 250 | [
"DDInter40",
"DDInter220"
] | Alefacept | Blinatumomab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
58,
24,
250
]
],
[
[
58,
24,
949
],
[
949,
63,
250
]
],
[
[
58,
63,
305
],
[
305,
24,
250
]
],
[
[
58,
24,
1236
],
[
1236,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid a... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab
Alefacept m... |
DB00963 | DB09122 | 1,263 | 1,613 | [
"DDInter241",
"DDInter1409"
] | Bromfenac | Peginterferon beta-1a | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1263,
24,
1613
]
],
[
[
1263,
63,
1274
],
[
1274,
24,
1613
]
],
[
[
1263,
1,
831
],
[
831,
24,
1613
]
],
[
[
1263,
24,
1383
],
[
1383,... | [
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Bromfenac (Compound) resembles Indomethacin (Compound) and Indomethacin may cause a moderate inter... |
DB00047 | DB09413 | 176 | 1,203 | [
"DDInter932",
"DDInter1241"
] | Insulin glargine | Monopotassium phosphate | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia b... | Minor | 0 | [
[
[
176,
23,
1203
]
],
[
[
176,
24,
22
],
[
22,
23,
1203
]
],
[
[
176,
24,
22
],
[
22,
63,
1685
],
[
1685,
23,
1203
]
],
[
[
176,
23... | [
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Monopotassium phosphate"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephe... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a minor interaction that can limit clinical effects when taken with Monopotassium phosphate
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00352 | DB00500 | 482 | 24 | [
"DDInter1814",
"DDInter1831"
] | Tioguanine | Tolmetin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Moderate | 1 | [
[
[
482,
24,
24
]
],
[
[
482,
24,
886
],
[
886,
1,
24
]
],
[
[
482,
63,
1062
],
[
1062,
40,
24
]
],
[
[
482,
21,
28868
],
[
28868,
6... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Tolcapone and Tolcapone (Compound) resembles Tolmetin (Compound)
Tioguani... |
DB01037 | DB01156 | 1,161 | 593 | [
"DDInter1653",
"DDInter252"
] | Selegiline | Bupropion | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1161,
25,
593
]
],
[
[
1161,
6,
3486
],
[
3486,
45,
593
]
],
[
[
1161,
21,
29491
],
[
29491,
60,
593
]
],
[
[
1161,
23,
256
],
[
256,
... | [
[
[
"Selegiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Selegiline",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Bupropio... | Selegiline (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bupropion (Compound)
Selegiline (Compound) causes Dental caries (Side Effect) and Dental caries (Side Effect) is caused by Bupropion (Compound)
Selegiline may cause a minor interaction that can limit clinical effects when taken with Prasugrel and P... |
DB00480 | DB14409 | 1,668 | 1,129 | [
"DDInter1035",
"DDInter867"
] | Lenalidomide | Human adenovirus e serotype 4 strain cl-68578 antigen | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1668,
24,
1129
]
],
[
[
1668,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1668,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
1668,
63,
1184
],
[
11... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Lenalidomide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Lenalidomide may cause a moderate interaction that could exacerbate diseases when ... |
DB01259 | DB12457 | 392 | 1,180 | [
"DDInter1024",
"DDInter1598"
] | Lapatinib | Rimegepant | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
392,
24,
1180
]
],
[
[
392,
24,
741
],
[
741,
24,
1180
]
],
[
[
392,
63,
1419
],
[
1419,
24,
1180
]
],
[
[
392,
24,
1501
],
[
1501,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib m... |
DB00574 | DB09065 | 121 | 760 | [
"DDInter717",
"DDInter424"
] | Fenfluramine | Cobicistat | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
121,
24,
760
]
],
[
[
121,
23,
479
],
[
479,
23,
760
]
],
[
[
121,
24,
271
],
[
271,
23,
760
]
],
[
[
121,
64,
1230
],
[
1230,
2... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Fenfluramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
... | Fenfluramine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegr... |
DB00554 | DB01050 | 1,027 | 848 | [
"DDInter1478",
"DDInter900"
] | Piroxicam | Ibuprofen | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1027,
24,
848
]
],
[
[
1027,
6,
1829
],
[
1829,
45,
848
]
],
[
[
1027,
10,
11666
],
[
11666,
49,
848
]
],
[
[
1027,
54,
19122
],
[
191... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
"I... | Piroxicam (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Piroxicam (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Ibuprofen (Compound)
Piroxicam (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroi... |
DB00231 | DB00427 | 1,174 | 1,233 | [
"DDInter1761",
"DDInter1879"
] | Temazepam | Triprolidine | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
1174,
24,
1233
]
],
[
[
1174,
1,
686
],
[
686,
63,
1233
]
],
[
[
1174,
1,
523
],
[
523,
24,
1233
]
],
[
[
1174,
24,
104
],
[
104,
... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Temazepam",
"{u} (Compound) resembles {v} (Compound)",
"Oxazepam"
],
[
"Oxazepam",
"{u} may cause a moderate in... | Temazepam (Compound) resembles Oxazepam (Compound) and Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Temazepam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Te... |
DB00631 | DB06317 | 372 | 1,626 | [
"DDInter405",
"DDInter630"
] | Clofarabine | Elotuzumab | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
372,
24,
1626
]
],
[
[
372,
63,
1463
],
[
1463,
24,
1626
]
],
[
[
372,
24,
200
],
[
200,
63,
1626
]
],
[
[
372,
24,
671
],
[
671,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans an... |
DB06209 | DB11703 | 256 | 405 | [
"DDInter1508",
"DDInter9"
] | Prasugrel | Acalabrutinib | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
256,
25,
405
]
],
[
[
256,
63,
383
],
[
383,
24,
405
]
],
[
[
256,
24,
643
],
[
643,
24,
405
]
],
[
[
256,
25,
1598
],
[
1598,
6... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Prasugrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00424 | DB00562 | 19 | 1,014 | [
"DDInter896",
"DDInter188"
] | Hyoscyamine | Benzthiazide | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Minor | 0 | [
[
[
19,
23,
1014
]
],
[
[
19,
23,
811
],
[
811,
40,
1014
]
],
[
[
19,
23,
674
],
[
674,
1,
1014
]
],
[
[
19,
24,
1192
],
[
1192,
62,... | [
[
[
"Hyoscyamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Benzthiazide"
]
],
[
[
"Hyoscyamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
],
[
... | Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resembles Benzthiazide (Compound)
Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Benzth... |
DB00059 | DB00861 | 1,560 | 914 | [
"DDInter1404",
"DDInter551"
] | Pegaspargase | Diflunisal | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
1560,
24,
914
]
],
[
[
1560,
24,
1019
],
[
1019,
63,
914
]
],
[
[
1560,
24,
1512
],
[
1512,
24,
914
]
],
[
[
1560,
25,
976
],
[
976,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and ... |
DB00526 | DB01265 | 1,555 | 1,477 | [
"DDInter1355",
"DDInter1757"
] | Oxaliplatin | Telbivudine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
1555,
24,
1477
]
],
[
[
1555,
63,
141
],
[
141,
1,
1477
]
],
[
[
1555,
24,
231
],
[
231,
1,
1477
]
],
[
[
1555,
24,
112
],
[
112,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) resembles Telbivudine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine (Compound) resembles Telbivudine (Compou... |
DB00818 | DB14568 | 898 | 982 | [
"DDInter1538",
"DDInter1000"
] | Propofol | Ivosidenib | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
898,
24,
982
]
],
[
[
898,
23,
112
],
[
112,
23,
982
]
],
[
[
898,
24,
543
],
[
543,
24,
982
]
],
[
[
898,
63,
355
],
[
355,
24,... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Propofol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Propofol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperami... |
DB01030 | DB01610 | 869 | 248 | [
"DDInter1835",
"DDInter1912"
] | Topotecan | Valganciclovir | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
869,
24,
248
]
],
[
[
869,
63,
563
],
[
563,
1,
248
]
],
[
[
869,
21,
29209
],
[
29209,
60,
248
]
],
[
[
869,
63,
1101
],
[
1101,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
[... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Topotecan (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Topotecan may cause a moderate interac... |
DB00804 | DB01173 | 1,507 | 358 | [
"DDInter543",
"DDInter1349"
] | Dicyclomine | Orphenadrine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
1507,
24,
358
]
],
[
[
1507,
24,
211
],
[
211,
1,
358
]
],
[
[
1507,
24,
272
],
[
272,
24,
358
]
],
[
[
1507,
24,
820
],
[
820,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Orphenadrine (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate inte... |
DB00029 | DB00569 | 25 | 553 | [
"DDInter99",
"DDInter775"
] | Anistreplase | Fondaparinux | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Major | 2 | [
[
[
25,
25,
553
]
],
[
[
25,
23,
539
],
[
539,
62,
553
]
],
[
[
25,
24,
972
],
[
972,
63,
553
]
],
[
[
25,
24,
109
],
[
109,
24,
... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Fondaparinux
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate and ... |
DB00748 | DB00981 | 662 | 1,528 | [
"DDInter297",
"DDInter1462"
] | Carbinoxamine | Physostigmine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
662,
24,
1528
]
],
[
[
662,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
662,
63,
508
],
[
508,
24,
1528
]
],
[
[
662,
24,
1511
],
[
1511,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effe... | Carbinoxamine (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00280 | DB09135 | 494 | 1,211 | [
"DDInter575",
"DDInter967"
] | Disopyramide | Ioxilan | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
494,
24,
1211
]
],
[
[
494,
24,
1287
],
[
1287,
25,
1211
]
],
[
[
494,
25,
485
],
[
485,
25,
1211
]
],
[
[
494,
24,
1287
],
[
1287,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
],
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Amphotericin B and Amphotericin B may lead to a major life threatening interaction when taken with Ioxilan
Disopyramide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may lead to a ... |
DB00637 | DB11796 | 1,557 | 1,612 | [
"DDInter128",
"DDInter786"
] | Astemizole | Fostemsavir | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1557,
24,
1612
]
],
[
[
1557,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
1557,
63,
1101
],
[
1101,
23,
1612
]
],
[
[
1557,
24,
1040
],
[
10... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarot... |
DB00603 | DB06168 | 303 | 1,531 | [
"DDInter1137",
"DDInter281"
] | Medroxyprogesterone acetate | Canakinumab | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
303,
24,
1531
]
],
[
[
303,
25,
1476
],
[
1476,
63,
1531
]
],
[
[
303,
24,
1213
],
[
1213,
24,
1531
]
],
[
[
303,
24,
1093
],
[
1093,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigati... | Medroxyprogesterone acetate may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with D... |
DB00026 | DB11714 | 1,184 | 1,316 | [
"DDInter94",
"DDInter610"
] | Anakinra | Durvalumab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Moderate | 1 | [
[
[
1184,
24,
1316
]
],
[
[
1184,
23,
1461
],
[
1461,
23,
1316
]
],
[
[
1184,
24,
167
],
[
167,
24,
1316
]
],
[
[
1184,
24,
270
],
[
270,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Durvalumab"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vi... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortiso... |
DB00635 | DB01324 | 1,573 | 178 | [
"DDInter1515",
"DDInter1490"
] | Prednisone | Polythiazide | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
1573,
24,
178
]
],
[
[
1573,
24,
674
],
[
674,
40,
178
]
],
[
[
1573,
63,
1014
],
[
1014,
40,
178
]
],
[
[
1573,
21,
30696
],
[
30696,... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles ... |
DB01159 | DB09268 | 419 | 1,662 | [
"DDInter854",
"DDInter1464"
] | Halothane | Picosulfuric acid | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
419,
24,
1662
]
],
[
[
419,
24,
484
],
[
484,
63,
1662
]
],
[
[
419,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
419,
24,
1491
],
[
1491,
... | [
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Halothane may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Halothane may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib... |
DB00277 | DB09122 | 1,031 | 1,613 | [
"DDInter1791",
"DDInter1409"
] | Theophylline | Peginterferon beta-1a | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1031,
24,
1613
]
],
[
[
1031,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
1031,
63,
600
],
[
600,
24,
1613
]
],
[
[
1031,
24,
1383
],
[
1383... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Fluc... |
DB09237 | DB11901 | 1,586 | 913 | [
"DDInter1045",
"DDInter107"
] | Levamlodipine | Apalutamide | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1586,
25,
913
]
],
[
[
1586,
63,
600
],
[
600,
24,
913
]
],
[
[
1586,
64,
467
],
[
467,
24,
913
]
],
[
[
1586,
24,
1619
],
[
1619,
... | [
[
[
"Levamlodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
"Fl... | Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Levamlodipine may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin... |
DB00675 | DB01227 | 888 | 1,301 | [
"DDInter1744",
"DDInter1043"
] | Tamoxifen | Levacetylmethadol | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
888,
36,
1301
]
],
[
[
888,
64,
494
],
[
494,
1,
1301
]
],
[
[
888,
24,
307
],
[
307,
1,
1301
]
],
[
[
888,
40,
649
],
[
649,
1,... | [
[
[
"Tamoxifen",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyra... | Tamoxifen (Compound) resembles Levacetylmethadol (Compound) and
Tamoxifen may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Modafinil a... |
DB00860 | DB04834 | 891 | 276 | [
"DDInter1513",
"DDInter1571"
] | Prednisolone | Rapacuronium | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Moderate | 1 | [
[
[
891,
24,
276
]
],
[
[
891,
63,
1031
],
[
1031,
24,
276
]
],
[
[
891,
40,
251
],
[
251,
24,
276
]
],
[
[
891,
1,
175
],
[
175,
24... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rapacuronium"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Prednisolone (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a moderate intera... |
DB00252 | DB06723 | 362 | 115 | [
"DDInter1460",
"DDInter58"
] | Phenytoin | Aluminum hydroxide | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
362,
24,
115
]
],
[
[
362,
21,
28872
],
[
28872,
60,
115
]
],
[
[
362,
24,
870
],
[
870,
23,
115
]
],
[
[
362,
63,
1018
],
[
1018,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Phenytoin",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u} (Side E... | Phenytoin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Aluminum hydroxide (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects w... |
DB01076 | DB12130 | 700 | 1,017 | [
"DDInter133",
"DDInter1094"
] | Atorvastatin | Lorlatinib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
700,
24,
1017
]
],
[
[
700,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
700,
24,
14
],
[
14,
24,
1017
]
],
[
[
700,
62,
126
],
[
126,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Ro... |
DB08901 | DB09098 | 1,468 | 98 | [
"DDInter1492",
"DDInter1700"
] | Ponatinib | Somatrem | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1468,
24,
98
]
],
[
[
1468,
63,
168
],
[
168,
23,
98
]
],
[
[
1468,
63,
671
],
[
671,
24,
98
]
],
[
[
1468,
24,
159
],
[
159,
63... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin... |
DB01619 | DB06077 | 830 | 879 | [
"DDInter1441",
"DDInter1102"
] | Phenindamine | Lumateperone | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
830,
24,
879
]
],
[
[
830,
24,
407
],
[
407,
63,
879
]
],
[
[
830,
24,
1511
],
[
1511,
24,
879
]
],
[
[
830,
1,
537
],
[
537,
24... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzola... |
DB00773 | DB12825 | 896 | 1,375 | [
"DDInter702",
"DDInter1032"
] | Etoposide | Lefamulin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
896,
24,
1375
]
],
[
[
896,
24,
112
],
[
112,
23,
1375
]
],
[
[
896,
24,
159
],
[
159,
63,
1375
]
],
[
[
896,
24,
1532
],
[
1532,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and La... |
DB00352 | DB08896 | 482 | 292 | [
"DDInter1814",
"DDInter1576"
] | Tioguanine | Regorafenib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
482,
24,
292
]
],
[
[
482,
24,
79
],
[
79,
1,
292
]
],
[
[
482,
21,
28989
],
[
28989,
60,
292
]
],
[
[
482,
63,
1560
],
[
1560,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Tioguanine (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Regorafenib (Compound)
Tioguanine may cause a moderate in... |
DB01601 | DB01611 | 833 | 1,487 | [
"DDInter1089",
"DDInter893"
] | Lopinavir | Hydroxychloroquine | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
833,
25,
1487
]
],
[
[
833,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
833,
62,
597
],
[
597,
24,
1487
]
],
[
[
833,
24,
286
],
[
286,
... | [
[
[
"Lopinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Lopinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"H... | Lopinavir (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Lopinavir may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroqu... |
DB00346 | DB00604 | 472 | 1,425 | [
"DDInter44",
"DDInter385"
] | Alfuzosin | Cisapride | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Major | 2 | [
[
[
472,
25,
1425
]
],
[
[
472,
6,
8374
],
[
8374,
45,
1425
]
],
[
[
472,
7,
2216
],
[
2216,
46,
1425
]
],
[
[
472,
23,
112
],
[
112,
... | [
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cisapride"... | Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cisapride (Compound)
Alfuzosin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Cisapride (Compound)
Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may caus... |
DB01246 | DB06655 | 820 | 5 | [
"DDInter45",
"DDInter1077"
] | Alimemazine | Liraglutide | A phenothiazine derivative that is used as an antipruritic. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
820,
24,
5
]
],
[
[
820,
63,
743
],
[
743,
23,
5
]
],
[
[
820,
24,
651
],
[
651,
24,
5
]
],
[
[
820,
63,
245
],
[
245,
24,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
[... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fos... |
DB00872 | DB11828 | 1,080 | 1,406 | [
"DDInter438",
"DDInter1281"
] | Conivaptan | Neratinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
1080,
25,
1406
]
],
[
[
1080,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
1080,
25,
392
],
[
392,
24,
1406
]
],
[
[
1080,
63,
1195
],
[
1195... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Conivaptan may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Conivaptan may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction... |
DB01083 | DB01232 | 1,142 | 1,327 | [
"DDInter1348",
"DDInter1640"
] | Orlistat | Saquinavir | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
1142,
24,
1327
]
],
[
[
1142,
63,
798
],
[
798,
40,
1327
]
],
[
[
1142,
6,
8374
],
[
8374,
45,
1327
]
],
[
[
1142,
21,
28936
],
[
2893... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Orlistat (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saquinavir (Compound)
Orlistat (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidros... |
DB00563 | DB00740 | 663 | 424 | [
"DDInter1174",
"DDInter1596"
] | Methotrexate | Riluzole | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. | Moderate | 1 | [
[
[
663,
24,
424
]
],
[
[
663,
6,
17404
],
[
17404,
45,
424
]
],
[
[
663,
7,
18110
],
[
18110,
46,
424
]
],
[
[
663,
18,
2801
],
[
2801,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riluzole"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",... | Methotrexate (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Riluzole (Compound)
Methotrexate (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Riluzole (Compound)
Methotrexate (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Riluzole (Compound)
Methot... |
DB00472 | DB01156 | 758 | 593 | [
"DDInter758",
"DDInter252"
] | Fluoxetine | Bupropion | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
758,
25,
593
]
],
[
[
758,
6,
8374
],
[
8374,
45,
593
]
],
[
[
758,
10,
11621
],
[
11621,
49,
593
]
],
[
[
758,
18,
10375
],
[
10375,
... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bupropio... | Fluoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Fluoxetine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Bupropion (Compound)
Fluoxetine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Bupropion (Compo... |
DB08889 | DB11627 | 350 | 1,367 | [
"DDInter299",
"DDInter860"
] | Carfilzomib | Hepatitis B Vaccine (Recombinant) | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
350,
24,
1367
]
],
[
[
350,
63,
1560
],
[
1560,
24,
1367
]
],
[
[
350,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
350,
24,
1480
],
[
1480,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pe... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Carfilzomib may lead to a major life threatening interaction when taken with Cladrib... |
DB00635 | DB06819 | 1,573 | 754 | [
"DDInter1515",
"DDInter1452"
] | Prednisone | Phenylbutyric acid | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and ur... | Moderate | 1 | [
[
[
1573,
24,
754
]
],
[
[
1573,
1,
891
],
[
891,
24,
754
]
],
[
[
1573,
40,
251
],
[
251,
24,
754
]
],
[
[
1573,
63,
1236
],
[
1236,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutyric acid"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound)",
"Prednisolone"
],
[
"Prednisolone",
"{u} may cau... | Prednisone (Compound) resembles Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Prednisone (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when take... |
DB00631 | DB13179 | 372 | 68 | [
"DDInter405",
"DDInter1882"
] | Clofarabine | Troleandomycin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
372,
24,
68
]
],
[
[
372,
63,
1101
],
[
1101,
23,
68
]
],
[
[
372,
24,
1374
],
[
1374,
23,
68
]
],
[
[
372,
24,
267
],
[
267,
24... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and A... |
DB00284 | DB01357 | 1,647 | 890 | [
"DDInter11",
"DDInter1160"
] | Acarbose | Mestranol | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
1647,
24,
890
]
],
[
[
1647,
24,
1197
],
[
1197,
40,
890
]
],
[
[
1647,
24,
559
],
[
559,
1,
890
]
],
[
[
1647,
24,
1486
],
[
1486,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles Mestranol (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Estrone and Estrone (Compound) resembles Mestranol (Compound)
Acar... |
DB00252 | DB00277 | 362 | 1,031 | [
"DDInter1460",
"DDInter1791"
] | Phenytoin | Theophylline | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Moderate | 1 | [
[
[
362,
24,
1031
]
],
[
[
362,
6,
6017
],
[
6017,
45,
1031
]
],
[
[
362,
21,
28991
],
[
28991,
60,
1031
]
],
[
[
362,
23,
1096
],
[
1096,... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Phenytoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Theophylline (Compound)
Phenytoin (Compound) causes Gastric irritation (Side Effect) and Gastric irritation (Side Effect) is caused by Theophylline (Compound)
Phenytoin may cause a minor interaction that can limit clinical effects when taken with My... |
DB00569 | DB01191 | 553 | 1,039 | [
"DDInter775",
"DDInter518"
] | Fondaparinux | Dexfenfluramine | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
553,
24,
1039
]
],
[
[
553,
25,
1046
],
[
1046,
63,
1039
]
],
[
[
553,
25,
935
],
[
935,
24,
1039
]
],
[
[
553,
64,
702
],
[
702,
... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
],
[
... | Fondaparinux may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Fondaparinux may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen may cause a ... |
DB09073 | DB13179 | 951 | 68 | [
"DDInter1379",
"DDInter1882"
] | Palbociclib | Troleandomycin | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
951,
25,
68
]
],
[
[
951,
63,
1101
],
[
1101,
23,
68
]
],
[
[
951,
24,
710
],
[
710,
24,
68
]
],
[
[
951,
63,
1220
],
[
1220,
24... | [
[
[
"Palbociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexa... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and B... |
DB00612 | DB09134 | 1,121 | 1,552 | [
"DDInter216",
"DDInter966"
] | Bisoprolol | Ioversol | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
1121,
24,
1552
]
],
[
[
1121,
1,
819
],
[
819,
24,
1552
]
],
[
[
1121,
40,
726
],
[
726,
24,
1552
]
],
[
[
1121,
63,
1648
],
[
1648,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Bisoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Acebutolol"
],
[
"Acebutolol",
"{u} may cause a moderate ... | Bisoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Bisoprolol (Compound) resembles Betaxolol (Compound) and Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Bisopr... |
DB01069 | DB11827 | 401 | 433 | [
"DDInter1533",
"DDInter669"
] | Promethazine | Ertugliflozin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
401,
24,
433
]
],
[
[
401,
63,
1020
],
[
1020,
24,
433
]
],
[
[
401,
64,
1176
],
[
1176,
24,
433
]
],
[
[
401,
24,
1508
],
[
1508,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Promethazine may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin m... |
DB11901 | DB12141 | 913 | 971 | [
"DDInter107",
"DDInter817"
] | Apalutamide | Gilteritinib | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
913,
25,
971
]
],
[
[
913,
64,
1135
],
[
1135,
23,
971
]
],
[
[
913,
62,
1247
],
[
1247,
23,
971
]
],
[
[
913,
25,
466
],
[
466,
... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u}... | Apalutamide may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Apalutamide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole ... |
DB01069 | DB11730 | 401 | 351 | [
"DDInter1533",
"DDInter1588"
] | Promethazine | Ribociclib | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
401,
25,
351
]
],
[
[
401,
24,
271
],
[
271,
23,
351
]
],
[
[
401,
62,
1247
],
[
1247,
23,
351
]
],
[
[
401,
24,
283
],
[
283,
6... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
],
[
"Mirabe... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Promethazine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and ... |
DB00414 | DB08869 | 590 | 162 | [
"DDInter16",
"DDInter1773"
] | Acetohexamide | Tesamorelin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and... | Moderate | 1 | [
[
[
590,
24,
162
]
],
[
[
590,
24,
170
],
[
170,
24,
162
]
],
[
[
590,
24,
1344
],
[
1344,
63,
162
]
],
[
[
590,
63,
176
],
[
176,
2... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tesamorelin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tesamorelin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozi... |
DB06186 | DB06228 | 1,439 | 792 | [
"DDInter969",
"DDInter1609"
] | Ipilimumab | Rivaroxaban | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1439,
25,
792
]
],
[
[
1439,
63,
453
],
[
453,
40,
792
]
],
[
[
1439,
24,
1412
],
[
1412,
63,
792
]
],
[
[
1439,
63,
597
],
[
597,
... | [
[
[
"Ipilimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
],
[
"Linezolid"... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Linezolid and Linezolid (Compound) resembles Rivaroxaban (Compound)
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and Calaspargase pegol may cause a moderate interac... |
DB00877 | DB14509 | 629 | 1,399 | [
"DDInter1678",
"DDInter1081"
] | Sirolimus | Lithium carbonate | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
629,
25,
1399
]
],
[
[
629,
64,
589
],
[
589,
23,
1399
]
],
[
[
629,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
629,
63,
1010
],
[
1010,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
],
[
"Cisplatin",
"{u... | Sirolimus may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide and Semaglutide may cau... |
DB00472 | DB00983 | 758 | 480 | [
"DDInter758",
"DDInter776"
] | Fluoxetine | Formoterol | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
758,
24,
480
]
],
[
[
758,
24,
1148
],
[
1148,
63,
480
]
],
[
[
758,
6,
6017
],
[
6017,
45,
480
]
],
[
[
758,
18,
10375
],
[
10375,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Fluoxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Formoterol (Compound)
Fluoxetine (Co... |
DB00627 | DB09122 | 265 | 1,613 | [
"DDInter1286",
"DDInter1409"
] | Niacin | Peginterferon beta-1a | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
265,
24,
1613
]
],
[
[
265,
24,
267
],
[
267,
24,
1613
]
],
[
[
265,
63,
1560
],
[
1560,
24,
1613
]
],
[
[
265,
25,
14
],
[
14,
... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Niacin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and P... |
DB00812 | DB09134 | 998 | 1,552 | [
"DDInter1451",
"DDInter966"
] | Phenylbutazone | Ioversol | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
998,
25,
1552
]
],
[
[
998,
24,
848
],
[
848,
25,
1552
]
],
[
[
998,
63,
1274
],
[
1274,
25,
1552
]
],
[
[
998,
25,
629
],
[
629,
... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibupr... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead to a major life threatening interaction when taken with Ioversol
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen ma... |
DB00687 | DB10315 | 870 | 1,137 | [
"DDInter747",
"DDInter1127"
] | Fludrocortisone | Measles virus vaccine live attenuated | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
870,
25,
1137
]
],
[
[
870,
64,
581
],
[
581,
25,
1137
]
],
[
[
870,
24,
384
],
[
384,
25,
1137
]
],
[
[
870,
63,
1101
],
[
1101,
... | [
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
... | Fludrocortisone may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and... |
DB00328 | DB01105 | 831 | 222 | [
"DDInter921",
"DDInter1665"
] | Indomethacin | Sibutramine | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
831,
24,
222
]
],
[
[
831,
21,
29215
],
[
29215,
60,
222
]
],
[
[
831,
24,
384
],
[
384,
62,
222
]
],
[
[
831,
23,
752
],
[
752,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Indomethacin",
"{u} (Compound) causes {v} (Side Effect)",
"Ecchymosis"
],
[
"Ecchymosis",
"{u} (Side Effect) ... | Indomethacin (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Sibutramine (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Si... |
DB00023 | DB01406 | 305 | 984 | [
"DDInter127",
"DDInter472"
] | Asparaginase Escherichia coli | Danazol | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
305,
24,
984
]
],
[
[
305,
24,
1546
],
[
1546,
1,
984
]
],
[
[
305,
24,
1026
],
[
1026,
40,
984
]
],
[
[
305,
24,
127
],
[
127,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Danazol (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Ox... |
DB00286 | DB00682 | 380 | 126 | [
"DDInter439",
"DDInter1951"
] | Conjugated estrogens | Warfarin | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
380,
24,
126
]
],
[
[
380,
6,
7950
],
[
7950,
45,
126
]
],
[
[
380,
24,
135
],
[
135,
62,
126
]
],
[
[
380,
63,
1647
],
[
1647,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound b... | Conjugated estrogens (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Warfarin (Compound)
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide and Albiglutide may cause a minor interaction that can limit clinical effects when taken with Warfarin
Co... |
DB00526 | DB00601 | 1,555 | 453 | [
"DDInter1355",
"DDInter1073"
] | Oxaliplatin | Linezolid | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
1555,
24,
453
]
],
[
[
1555,
25,
770
],
[
770,
63,
453
]
],
[
[
1555,
24,
713
],
[
713,
63,
453
]
],
[
[
1555,
63,
10
],
[
10,
2... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
],
[
"Thalidom... | Oxaliplatin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fu... |
DB00619 | DB11003 | 1,419 | 748 | [
"DDInter909",
"DDInter100"
] | Imatinib | Anthrax vaccine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1419,
24,
748
]
],
[
[
1419,
63,
322
],
[
322,
24,
748
]
],
[
[
1419,
24,
896
],
[
896,
24,
748
]
],
[
[
1419,
25,
594
],
[
594,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etopos... |
DB09280 | DB14840 | 1,604 | 861 | [
"DDInter1101",
"DDInter1601"
] | Lumacaftor | Ripretinib | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Major | 2 | [
[
[
1604,
25,
861
]
],
[
[
1604,
25,
214
],
[
214,
24,
861
]
],
[
[
1604,
63,
973
],
[
973,
24,
861
]
],
[
[
1604,
64,
1362
],
[
1362,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ripretinib"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
],
[
"Fostamatinib",
"{... | Lumacaftor may lead to a major life threatening interaction when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Lumacaftor may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may ca... |
DB00317 | DB01149 | 883 | 851 | [
"DDInter810",
"DDInter1274"
] | Gefitinib | Nefazodone | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
883,
24,
851
]
],
[
[
883,
24,
673
],
[
673,
40,
851
]
],
[
[
883,
6,
8374
],
[
8374,
45,
851
]
],
[
[
883,
7,
4759
],
[
4759,
4... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Nefazodone (Compound)
Gefitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Gefitinib (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (G... |
DB00370 | DB01611 | 1,251 | 1,487 | [
"DDInter1230",
"DDInter893"
] | Mirtazapine | Hydroxychloroquine | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1251,
25,
1487
]
],
[
[
1251,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
1251,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1251,
21,
28658
],
[
... | [
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Mirtazapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Mirtazapine (Co... |
DB00741 | DB06718 | 167 | 1,687 | [
"DDInter885",
"DDInter1709"
] | Hydrocortisone | Stanozolol | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
167,
24,
1687
]
],
[
[
167,
1,
11219
],
[
11219,
1,
1687
]
],
[
[
167,
35,
1546
],
[
1546,
1,
1687
]
],
[
[
167,
63,
1561
],
[
1561,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Testosterone Propionate"
],
[
"Testosterone Propionat... | Hydrocortisone (Compound) resembles Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Stanozolol (Compound)
Hydrocortisone (Compound) resembles Methyltestosterone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestost... |
DB01037 | DB01088 | 1,161 | 714 | [
"DDInter1653",
"DDInter908"
] | Selegiline | Iloprost | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1161,
24,
714
]
],
[
[
1161,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1161,
24,
1637
],
[
1637,
63,
714
]
],
[
[
1161,
75,
1445
],
[
1445,... | [
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite and Amyl... |
DB01143 | DB09401 | 923 | 928 | [
"DDInter65",
"DDInter988"
] | Amifostine | Isosorbide | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the... | Moderate | 1 | [
[
[
923,
24,
928
]
],
[
[
923,
63,
1061
],
[
1061,
24,
928
]
],
[
[
923,
24,
885
],
[
885,
24,
928
]
],
[
[
923,
63,
1061
],
[
1061,
... | [
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide"
]
],
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide
Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and ... |
DB00006 | DB00054 | 942 | 1,432 | [
"DDInter217",
"DDInter6"
] | Bivalirudin | Abciximab | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Moderate | 1 | [
[
[
942,
24,
1432
]
],
[
[
942,
23,
539
],
[
539,
62,
1432
]
],
[
[
942,
24,
714
],
[
714,
63,
1432
]
],
[
[
942,
25,
477
],
[
477,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abciximab"
]
],
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
... | Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Abciximab
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may ca... |
DB00472 | DB11730 | 758 | 351 | [
"DDInter758",
"DDInter1588"
] | Fluoxetine | Ribociclib | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
758,
25,
351
]
],
[
[
758,
23,
112
],
[
112,
23,
351
]
],
[
[
758,
25,
222
],
[
222,
23,
351
]
],
[
[
758,
24,
283
],
[
283,
62,... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Fluoxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Fluoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Fluoxetine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may ca... |
DB01041 | DB12141 | 770 | 971 | [
"DDInter1789",
"DDInter817"
] | Thalidomide | Gilteritinib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
770,
24,
971
]
],
[
[
770,
63,
112
],
[
112,
23,
971
]
],
[
[
770,
63,
485
],
[
485,
24,
971
]
],
[
[
770,
24,
1097
],
[
1097,
2... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB06704 | DB10795 | 247 | 221 | [
"DDInter952",
"DDInter1486"
] | Iobenguane (I-131) | Poliovirus type 1 antigen (formaldehyde inactivated) | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
247,
24,
221
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
24,
221
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
24,
... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1"... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate ... |
DB01053 | DB09420 | 514 | 1,074 | [
"DDInter189",
"DDInter953"
] | Benzylpenicillin | Iodide I-123 | Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible o... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
514,
24,
1074
]
],
[
[
514,
40,
339
],
[
339,
24,
1074
]
],
[
[
514,
63,
126
],
[
126,
24,
1074
]
],
[
[
514,
1,
1681
],
[
1681,
... | [
[
[
"Benzylpenicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Benzylpenicillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicillin",
"{u}... | Benzylpenicillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Benzylpenicillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate intera... |
DB00196 | DB00738 | 600 | 485 | [
"DDInter743",
"DDInter1420"
] | Fluconazole | Pentamidine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
600,
24,
485
]
],
[
[
600,
25,
1423
],
[
1423,
1,
485
]
],
[
[
600,
6,
7524
],
[
7524,
45,
485
]
],
[
[
600,
7,
4603
],
[
4603,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ospemifene"
],
[
"Ospemif... | Fluconazole may lead to a major life threatening interaction when taken with Ospemifene and Ospemifene (Compound) resembles Pentamidine (Compound)
Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Pentamidine (Compound)
Fluconazole (Compound) upregulates RAB11FIP2 (Gene) and RAB11FIP2 (Gene) is u... |
DB08912 | DB11995 | 1,040 | 1,634 | [
"DDInter462",
"DDInter143"
] | Dabrafenib | Avatrombopag | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Major | 2 | [
[
[
1040,
25,
1634
]
],
[
[
1040,
63,
1622
],
[
1622,
24,
1634
]
],
[
[
1040,
24,
760
],
[
760,
24,
1634
]
],
[
[
1040,
64,
171
],
[
171,
... | [
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avatrombopag"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
],
[
"Vorico... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and ... |
DB00046 | DB00519 | 1,179 | 1,638 | [
"DDInter940",
"DDInter1843"
] | Insulin lispro | Trandolapril | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
1179,
24,
1638
]
],
[
[
1179,
24,
954
],
[
954,
40,
1638
]
],
[
[
1179,
24,
170
],
[
170,
63,
1638
]
],
[
[
1179,
24,
1560
],
[
1560,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction ... |
DB09268 | DB14158 | 1,662 | 882 | [
"DDInter1464",
"DDInter1211"
] | Picosulfuric acid | Microcrystalline cellulose | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical prepara... | Minor | 0 | [
[
[
1662,
23,
882
]
],
[
[
1662,
62,
16
],
[
16,
23,
882
]
],
[
[
1662,
63,
355
],
[
355,
24,
882
]
],
[
[
1662,
62,
16
],
[
16,
62,... | [
[
[
"Picosulfuric acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Microcrystalline cellulose"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"L... | Picosulfuric acid may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Microcrystalline cellulose
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when take... |
DB00372 | DB00470 | 999 | 530 | [
"DDInter1793",
"DDInter601"
] | Thiethylperazine | Dronabinol | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
999,
24,
530
]
],
[
[
999,
24,
1614
],
[
1614,
40,
530
]
],
[
[
999,
63,
701
],
[
701,
24,
530
]
],
[
[
999,
24,
336
],
[
336,
6... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction th... |
DB00773 | DB11932 | 896 | 327 | [
"DDInter702",
"DDInter3"
] | Etoposide | Abametapir (topical) | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
896,
24,
327
]
],
[
[
896,
24,
124
],
[
124,
63,
327
]
],
[
[
896,
63,
168
],
[
168,
24,
327
]
],
[
[
896,
24,
309
],
[
309,
24,... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Etoposide may ... |
DB00475 | DB00835 | 1,119 | 100 | [
"DDInter355",
"DDInter245"
] | Chlordiazepoxide | Brompheniramine | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1119,
24,
100
]
],
[
[
1119,
24,
832
],
[
832,
24,
100
]
],
[
[
1119,
63,
128
],
[
128,
24,
100
]
],
[
[
1119,
24,
649
],
[
649,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelenna... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00366 | DB00371 | 1,594 | 1,050 | [
"DDInter600",
"DDInter1154"
] | Doxylamine | Meprobamate | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Moderate | 1 | [
[
[
1594,
24,
1050
]
],
[
[
1594,
24,
210
],
[
210,
1,
1050
]
],
[
[
1594,
21,
28741
],
[
28741,
60,
1050
]
],
[
[
1594,
24,
222
],
[
222,... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meprobamate"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carisoprodol"
],
[... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carisoprodol and Carisoprodol (Compound) resembles Meprobamate (Compound)
Doxylamine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Meprobamate (Compound)
Doxylamine may cause a moderate intera... |
DB01024 | DB11901 | 1,096 | 913 | [
"DDInter1252",
"DDInter107"
] | Mycophenolic acid | Apalutamide | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1096,
24,
913
]
],
[
[
1096,
63,
112
],
[
112,
23,
913
]
],
[
[
1096,
64,
303
],
[
303,
24,
913
]
],
[
[
1096,
24,
609
],
[
609,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazol... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Mycophenolic acid may lead to a major life threatening interaction when taken with Medroxyprogestero... |
DB00022 | DB01097 | 268 | 1,377 | [
"DDInter1408",
"DDInter1033"
] | Peginterferon alfa-2b | Leflunomide | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
268,
25,
1377
]
],
[
[
268,
24,
242
],
[
242,
63,
1377
]
],
[
[
268,
25,
1477
],
[
1477,
63,
1377
]
],
[
[
268,
24,
126
],
[
126,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Peginterferon alfa-2b may lead to a major life threatening interaction when taken with Telbivudine a... |
DB00792 | DB05541 | 832 | 801 | [
"DDInter1878",
"DDInter239"
] | Tripelennamine | Brivaracetam | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
832,
24,
801
]
],
[
[
832,
63,
475
],
[
475,
24,
801
]
],
[
[
832,
24,
100
],
[
100,
24,
801
]
],
[
[
832,
35,
272
],
[
272,
24,... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine... |
DB00501 | DB12301 | 752 | 907 | [
"DDInter380",
"DDInter585"
] | Cimetidine | Doravirine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
752,
23,
907
]
],
[
[
752,
24,
1478
],
[
1478,
23,
907
]
],
[
[
752,
24,
159
],
[
159,
62,
907
]
],
[
[
752,
25,
1213
],
[
1213,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotre... |
DB06616 | DB10795 | 594 | 221 | [
"DDInter224",
"DDInter1486"
] | Bosutinib | Poliovirus type 1 antigen (formaldehyde inactivated) | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
594,
24,
221
]
],
[
[
594,
24,
36
],
[
36,
24,
221
]
],
[
[
594,
64,
581
],
[
581,
24,
221
]
],
[
[
594,
63,
599
],
[
599,
24,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Bosutinib may lead to a major life threatening interaction when taken with ... |
DB00014 | DB01069 | 521 | 401 | [
"DDInter839",
"DDInter1533"
] | Goserelin | Promethazine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
521,
24,
401
]
],
[
[
521,
24,
1264
],
[
1264,
63,
401
]
],
[
[
521,
21,
28709
],
[
28709,
60,
401
]
],
[
[
521,
24,
286
],
[
286,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Goserelin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Promet... |
DB00352 | DB00619 | 482 | 1,419 | [
"DDInter1814",
"DDInter909"
] | Tioguanine | Imatinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
482,
24,
1419
]
],
[
[
482,
5,
11555
],
[
11555,
44,
1419
]
],
[
[
482,
21,
28709
],
[
28709,
60,
1419
]
],
[
[
482,
63,
1101
],
[
110... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Tioguanine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease)... | Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Imatinib (Compound)
Tioguanine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Imatinib (Compound)
Tioguanine may cause a moderate interaction that could exacerba... |
DB01058 | DB12267 | 978 | 1,476 | [
"DDInter1510",
"DDInter233"
] | Praziquantel | Brigatinib | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
978,
24,
1476
]
],
[
[
978,
24,
800
],
[
800,
24,
1476
]
],
[
[
978,
24,
1598
],
[
1598,
63,
1476
]
],
[
[
978,
63,
288
],
[
288,
... | [
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
],
[... | Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib and Duvelisib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Ta... |
DB00470 | DB00700 | 530 | 312 | [
"DDInter601",
"DDInter656"
] | Dronabinol | Eplerenone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Moderate | 1 | [
[
[
530,
24,
312
]
],
[
[
530,
63,
443
],
[
443,
1,
312
]
],
[
[
530,
6,
8374
],
[
8374,
45,
312
]
],
[
[
530,
21,
28762
],
[
28762,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone (Compound) resembles Eplerenone (Compound)
Dronabinol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Eplerenone (Compound)
Dronabinol (Compound) causes Headache (Side Effect) and He... |
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