drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00373 | DB09564 | 461 | 1,296 | [
"DDInter1809",
"DDInter930"
] | Timolol | Insulin degludec | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
461,
24,
1296
]
],
[
[
461,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
461,
25,
659
],
[
659,
24,
1296
]
],
[
[
461,
23,
542
],
[
542,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Timolol may lead to a major life threatening interaction when taken with Vilanterol and Vilanterol may caus... |
DB00843 | DB12267 | 479 | 1,476 | [
"DDInter583",
"DDInter233"
] | Donepezil | Brigatinib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
479,
24,
1476
]
],
[
[
479,
23,
951
],
[
951,
24,
1476
]
],
[
[
479,
63,
79
],
[
79,
24,
1476
]
],
[
[
479,
62,
883
],
[
883,
24... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Palbociclib"
],
[
... | Donepezil may cause a minor interaction that can limit clinical effects when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib... |
DB00363 | DB09564 | 695 | 1,296 | [
"DDInter419",
"DDInter930"
] | Clozapine | Insulin degludec | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
695,
24,
1296
]
],
[
[
695,
24,
274
],
[
274,
23,
1296
]
],
[
[
695,
25,
1621
],
[
1621,
23,
1296
]
],
[
[
695,
24,
1411
],
[
1411,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
],
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Clozapine may lead to a major life threatening interaction when taken with Potassium chloride and Potassi... |
DB01591 | DB11901 | 667 | 913 | [
"DDInter1696",
"DDInter107"
] | Solifenacin | Apalutamide | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
667,
24,
913
]
],
[
[
667,
62,
112
],
[
112,
23,
913
]
],
[
[
667,
63,
600
],
[
600,
24,
913
]
],
[
[
667,
24,
28
],
[
28,
24,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Solifenacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Solifenacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB00620 | DB00776 | 175 | 1,335 | [
"DDInter1855",
"DDInter1360"
] | Triamcinolone | Oxcarbazepine | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
175,
24,
1335
]
],
[
[
175,
24,
1605
],
[
1605,
1,
1335
]
],
[
[
175,
63,
1236
],
[
1236,
1,
1335
]
],
[
[
175,
23,
307
],
[
307,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Oxcarba... |
DB00539 | DB01174 | 11 | 697 | [
"DDInter1837",
"DDInter1442"
] | Toremifene | Phenobarbital | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Major | 2 | [
[
[
11,
25,
697
]
],
[
[
11,
25,
759
],
[
759,
1,
697
]
],
[
[
11,
64,
362
],
[
362,
1,
697
]
],
[
[
11,
63,
536
],
[
536,
40,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenobarbital"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primidone"
],
[
"Primidone",
"{u} ... | Toremifene may lead to a major life threatening interaction when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Toremifene may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound)
Toremifene may cause a moder... |
DB01100 | DB01362 | 1,568 | 497 | [
"DDInter1470",
"DDInter960"
] | Pimozide | Iohexol | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1568,
25,
497
]
],
[
[
1568,
21,
28787
],
[
28787,
60,
497
]
],
[
[
1568,
63,
999
],
[
999,
25,
497
]
],
[
[
1568,
25,
1264
],
[
1264,... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Pimozide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (Compound)... | Pimozide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when taken with Iohexol
Pimozid... |
DB00081 | DB00500 | 273 | 24 | [
"DDInter1838",
"DDInter1831"
] | Tositumomab | Tolmetin | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Major | 2 | [
[
[
273,
25,
24
]
],
[
[
273,
37,
886
],
[
886,
1,
24
]
],
[
[
273,
24,
1263
],
[
1263,
1,
24
]
],
[
[
273,
25,
831
],
[
831,
40,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tolmetin"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening intera... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Tositumomab may lead to a major life threatening interaction when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)
Tositumomab may cause a moderate interaction that could exacerbate disea... |
DB00472 | DB04951 | 758 | 187 | [
"DDInter758",
"DDInter1477"
] | Fluoxetine | Pirfenidone | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
758,
24,
187
]
],
[
[
758,
25,
1670
],
[
1670,
63,
187
]
],
[
[
758,
24,
1017
],
[
1017,
63,
187
]
],
[
[
758,
24,
1419
],
[
1419,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
],
[
"Eliglusta... | Fluoxetine may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause... |
DB00046 | DB01367 | 1,179 | 1,163 | [
"DDInter940",
"DDInter1572"
] | Insulin lispro | Rasagiline | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1179,
24,
1163
]
],
[
[
1179,
24,
590
],
[
590,
24,
1163
]
],
[
[
1179,
23,
274
],
[
274,
24,
1163
]
],
[
[
1179,
24,
659
],
[
659,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Phentolam... |
DB00761 | DB01176 | 1,621 | 537 | [
"DDInter1497",
"DDInter453"
] | Potassium chloride | Cyclizine | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Major | 2 | [
[
[
1621,
25,
537
]
],
[
[
1621,
25,
1511
],
[
1511,
63,
537
]
],
[
[
1621,
25,
104
],
[
104,
1,
537
]
],
[
[
1621,
64,
13
],
[
13,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclizine"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mepenzolate"
],
[
"Mepenzola... | Potassium chloride may lead to a major life threatening interaction when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Potassium chloride may lead to a major life threatening interaction when taken with Methdilazine and Methdilazine (Com... |
DB00586 | DB09418 | 1,512 | 554 | [
"DDInter537",
"DDInter1501"
] | Diclofenac | Potassium perchlorate | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Moderate | 1 | [
[
[
1512,
24,
554
]
],
[
[
1512,
24,
935
],
[
935,
24,
554
]
],
[
[
1512,
64,
886
],
[
886,
24,
554
]
],
[
[
1512,
63,
598
],
[
598,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Diclofenac may lead to a major life threatening interaction when taken with Ketorolac and Ketorolac m... |
DB01001 | DB06292 | 688 | 549 | [
"DDInter1632",
"DDInter474"
] | Salbutamol | Dapagliflozin | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
688,
24,
549
]
],
[
[
688,
24,
1344
],
[
1344,
40,
549
]
],
[
[
688,
6,
8374
],
[
8374,
45,
549
]
],
[
[
688,
21,
29222
],
[
29222,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Salbutamol (Compound) causes Hypoglycaemia (Side Effec... |
DB00104 | DB00491 | 966 | 127 | [
"DDInter1323",
"DDInter1217"
] | Octreotide | Miglitol | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
966,
24,
127
]
],
[
[
966,
21,
29180
],
[
29180,
60,
127
]
],
[
[
966,
24,
245
],
[
245,
24,
127
]
],
[
[
966,
24,
1021
],
[
1021,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Octreotide",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal distension"
],
[
"Abdominal distension",
"{u} (... | Octreotide (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Miglitol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases w... |
DB05812 | DB09082 | 1,374 | 659 | [
"DDInter8",
"DDInter1934"
] | Abiraterone | Vilanterol | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1374,
24,
659
]
],
[
[
1374,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1374,
24,
927
],
[
927,
63,
659
]
],
[
[
1374,
25,
1155
],
[
1155,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and... |
DB06081 | DB14357 | 1,046 | 944 | [
"DDInter286",
"DDInter347"
] | Caplacizumab | Chamomile | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1046,
23,
944
]
],
[
[
1046,
25,
256
],
[
256,
23,
944
]
],
[
[
1046,
64,
582
],
[
582,
23,
944
]
],
[
[
1046,
63,
1061
],
[
1061,
... | [
[
[
"Caplacizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel"... | Caplacizumab may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Caplacizumab may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a minor interactio... |
DB00790 | DB06335 | 664 | 761 | [
"DDInter1431",
"DDInter1646"
] | Perindopril | Saxagliptin | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
664,
24,
761
]
],
[
[
664,
21,
28966
],
[
28966,
60,
761
]
],
[
[
664,
24,
104
],
[
104,
24,
761
]
],
[
[
664,
63,
1573
],
[
1573,
... | [
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Perindopril",
"{u} (Compound) causes {v} (Side Effect)",
"Upper respiratory tract infection"
],
[
"Upper respiratory... | Perindopril (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction... |
DB00792 | DB00924 | 832 | 1,405 | [
"DDInter1878",
"DDInter454"
] | Tripelennamine | Cyclobenzaprine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
832,
35,
1405
]
],
[
[
832,
40,
649
],
[
649,
63,
1405
]
],
[
[
832,
40,
11296
],
[
11296,
1,
1405
]
],
[
[
832,
1,
293
],
[
293,
... | [
[
[
"Tripelennamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Tripelennamine",
"{u} (Compound) resembles {v} (Compound)",
"Clofedanol"
],... | Tripelennamine (Compound) resembles Cyclobenzaprine (Compound) and
Tripelennamine (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine
Tripelennamine (Compound) resembles Bromodiphenhydramine (Compound) and Bromodiphenh... |
DB00352 | DB01250 | 482 | 712 | [
"DDInter1814",
"DDInter1334"
] | Tioguanine | Olsalazine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
482,
24,
712
]
],
[
[
482,
24,
50
],
[
50,
40,
712
]
],
[
[
482,
24,
886
],
[
886,
24,
712
]
],
[
[
482,
24,
445
],
[
445,
63,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
[... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac may cause a moderate interaction that c... |
DB00758 | DB00813 | 1,347 | 704 | [
"DDInter413",
"DDInter722"
] | Clopidogrel | Fentanyl | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Moderate | 1 | [
[
[
1347,
24,
704
]
],
[
[
1347,
63,
307
],
[
307,
1,
704
]
],
[
[
1347,
25,
543
],
[
543,
1,
704
]
],
[
[
1347,
24,
1322
],
[
1322,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
]
],
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Fentanyl (Compound)
Clopidogrel may lead to a major life threatening interaction when taken with Loperamide and Loperamide (Compound) resembles Fentanyl (Compound)
Clopidogrel may cau... |
DB00835 | DB00964 | 100 | 1,617 | [
"DDInter245",
"DDInter110"
] | Brompheniramine | Apraclonidine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Moderate | 1 | [
[
[
100,
24,
1617
]
],
[
[
100,
63,
1020
],
[
1020,
1,
1617
]
],
[
[
100,
24,
1084
],
[
1084,
40,
1617
]
],
[
[
100,
63,
876
],
[
876,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Apraclonidine (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine (Compound) resembles Apraclonidi... |
DB00501 | DB00679 | 752 | 684 | [
"DDInter380",
"DDInter1796"
] | Cimetidine | Thioridazine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Major | 2 | [
[
[
752,
25,
684
]
],
[
[
752,
24,
1237
],
[
1237,
40,
684
]
],
[
[
752,
62,
216
],
[
216,
1,
684
]
],
[
[
752,
6,
12523
],
[
12523,
... | [
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
"Clomip... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thioridazi... |
DB00418 | DB01168 | 536 | 1,053 | [
"DDInter1650",
"DDInter1526"
] | Secobarbital | Procarbazine | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
536,
24,
1053
]
],
[
[
536,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
536,
25,
126
],
[
126,
23,
1053
]
],
[
[
536,
40,
1269
],
[
1269,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Secobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is ... | Secobarbital (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Secobarbital may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Secobarbita... |
DB00472 | DB01611 | 758 | 1,487 | [
"DDInter758",
"DDInter893"
] | Fluoxetine | Hydroxychloroquine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
758,
25,
1487
]
],
[
[
758,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
758,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
758,
21,
28658
],
[
2865... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"Pr... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Fluoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Fluoxetine (Compo... |
DB06176 | DB09039 | 1,342 | 1,670 | [
"DDInter1616",
"DDInter629"
] | Romidepsin | Eliglustat | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
1342,
24,
1670
]
],
[
[
1342,
63,
479
],
[
479,
23,
1670
]
],
[
[
1342,
63,
1164
],
[
1164,
24,
1670
]
],
[
[
1342,
64,
839
],
[
839,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipra... |
DB00620 | DB09420 | 175 | 1,074 | [
"DDInter1855",
"DDInter953"
] | Triamcinolone | Iodide I-123 | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
175,
24,
1074
]
],
[
[
175,
24,
1004
],
[
1004,
63,
1074
]
],
[
[
175,
24,
126
],
[
126,
24,
1074
]
],
[
[
175,
40,
251
],
[
251,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with... |
DB06212 | DB11901 | 165 | 913 | [
"DDInter1833",
"DDInter107"
] | Tolvaptan | Apalutamide | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
165,
25,
913
]
],
[
[
165,
63,
600
],
[
600,
24,
913
]
],
[
[
165,
64,
609
],
[
609,
24,
913
]
],
[
[
165,
24,
1320
],
[
1320,
6... | [
[
[
"Tolvaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
"Fluconazol... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Tolvaptan may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin m... |
DB00621 | DB14761 | 1,026 | 242 | [
"DDInter1357",
"DDInter1578"
] | Oxandrolone | Remdesivir | A synthetic hormone with anabolic and androgenic properties. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1026,
24,
242
]
],
[
[
1026,
63,
1512
],
[
1512,
24,
242
]
],
[
[
1026,
25,
1377
],
[
1377,
24,
242
]
],
[
[
1026,
24,
384
],
[
384,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
... | Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Oxandrolone may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may ca... |
DB01168 | DB11988 | 1,053 | 270 | [
"DDInter1526",
"DDInter1321"
] | Procarbazine | Ocrelizumab | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1053,
24,
270
]
],
[
[
1053,
63,
1461
],
[
1461,
23,
270
]
],
[
[
1053,
24,
713
],
[
713,
24,
270
]
],
[
[
1053,
24,
287
],
[
287,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate an... |
DB01181 | DB09048 | 1,532 | 555 | [
"DDInter906",
"DDInter1284"
] | Ifosfamide | Netupitant | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
1532,
24,
555
]
],
[
[
1532,
63,
473
],
[
473,
24,
555
]
],
[
[
1532,
25,
676
],
[
676,
63,
555
]
],
[
[
1532,
25,
976
],
[
976,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Netupitant
Ifosfamide may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may ... |
DB00816 | DB06788 | 1,674 | 1,616 | [
"DDInter1346",
"DDInter864"
] | Orciprenaline | Histrelin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1674,
24,
1616
]
],
[
[
1674,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
1674,
24,
623
],
[
623,
24,
1616
]
],
[
[
1674,
24,
927
],
[
927,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Histrelin
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and... |
DB01069 | DB06077 | 401 | 879 | [
"DDInter1533",
"DDInter1102"
] | Promethazine | Lumateperone | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
401,
24,
879
]
],
[
[
401,
24,
1281
],
[
1281,
63,
879
]
],
[
[
401,
63,
1645
],
[
1645,
24,
879
]
],
[
[
401,
24,
392
],
[
392,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and... |
DB00224 | DB11978 | 215 | 124 | [
"DDInter917",
"DDInter822"
] | Indinavir | Glasdegib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
215,
25,
124
]
],
[
[
215,
25,
1135
],
[
1135,
23,
124
]
],
[
[
215,
24,
466
],
[
466,
62,
124
]
],
[
[
215,
25,
629
],
[
629,
2... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ca... | Indinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a m... |
DB00364 | DB06335 | 417 | 761 | [
"DDInter1717",
"DDInter1646"
] | Sucralfate | Saxagliptin | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
417,
24,
761
]
],
[
[
417,
21,
28643
],
[
28643,
60,
761
]
],
[
[
417,
23,
104
],
[
104,
24,
761
]
],
[
[
417,
24,
1296
],
[
1296,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Sucralfate",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effect) is cau... | Sucralfate (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Saxagliptin (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Saxa... |
DB01177 | DB01242 | 77 | 1,237 | [
"DDInter904",
"DDInter410"
] | Idarubicin | Clomipramine | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
77,
24,
1237
]
],
[
[
77,
64,
684
],
[
684,
1,
1237
]
],
[
[
77,
63,
1164
],
[
1164,
1,
1237
]
],
[
[
77,
63,
401
],
[
401,
24,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thiori... | Idarubicin may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
Ida... |
DB01234 | DB11003 | 1,220 | 748 | [
"DDInter513",
"DDInter100"
] | Dexamethasone | Anthrax vaccine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1220,
24,
748
]
],
[
[
1220,
62,
168
],
[
168,
24,
748
]
],
[
[
1220,
25,
594
],
[
594,
24,
748
]
],
[
[
1220,
24,
564
],
[
564,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Dexamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],... | Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Dexamethasone may lead to a major life threatening interaction when taken with Bosutinib and Bosutinib may... |
DB01168 | DB10315 | 1,053 | 1,137 | [
"DDInter1526",
"DDInter1127"
] | Procarbazine | Measles virus vaccine live attenuated | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1053,
25,
1137
]
],
[
[
1053,
64,
581
],
[
581,
25,
1137
]
],
[
[
1053,
63,
1184
],
[
1184,
25,
1137
]
],
[
[
1053,
25,
676
],
[
676,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Procarbazine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinr... |
DB00374 | DB06209 | 1,061 | 256 | [
"DDInter1852",
"DDInter1508"
] | Treprostinil | Prasugrel | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
1061,
24,
256
]
],
[
[
1061,
6,
17955
],
[
17955,
45,
256
]
],
[
[
1061,
21,
29276
],
[
29276,
60,
256
]
],
[
[
1061,
23,
944
],
[
944... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Treprostinil",
"{u} (Compound) binds {v} (Gene)",
"P2RY12"
],
[
"P2RY12",
"{u} (Gene) is bound by {v} (Compound... | Treprostinil (Compound) binds P2RY12 (Gene) and P2RY12 (Gene) is bound by Prasugrel (Compound)
Treprostinil (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Prasugrel (Compound)
Treprostinil may cause a minor interaction that can limit clinical effects when taken with Chamomile and... |
DB00006 | DB00712 | 942 | 1,274 | [
"DDInter217",
"DDInter763"
] | Bivalirudin | Flurbiprofen | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
942,
24,
1274
]
],
[
[
942,
24,
935
],
[
935,
63,
1274
]
],
[
[
942,
23,
297
],
[
297,
62,
1274
]
],
[
[
942,
24,
529
],
[
529,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may... |
DB01234 | DB11757 | 1,220 | 960 | [
"DDInter513",
"DDInter994"
] | Dexamethasone | Istradefylline | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
1220,
24,
960
]
],
[
[
1220,
24,
1135
],
[
1135,
23,
960
]
],
[
[
1220,
24,
1499
],
[
1499,
24,
960
]
],
[
[
1220,
63,
134
],
[
134,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Istradefylline
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine and... |
DB00976 | DB11793 | 1,056 | 738 | [
"DDInter1758",
"DDInter1297"
] | Telithromycin | Niraparib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1056,
24,
738
]
],
[
[
1056,
24,
466
],
[
466,
63,
738
]
],
[
[
1056,
25,
1213
],
[
1213,
24,
738
]
],
[
[
1056,
63,
663
],
[
663,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Telithromycin may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may... |
DB00601 | DB00911 | 453 | 458 | [
"DDInter1073",
"DDInter1811"
] | Linezolid | Tinidazole | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
453,
24,
458
]
],
[
[
453,
24,
112
],
[
112,
1,
458
]
],
[
[
453,
18,
18226
],
[
18226,
57,
458
]
],
[
[
453,
21,
29340
],
[
29340,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Linezolid (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Tinidazole (Compound)
Linezolid (Compound) causes Stevens-Johnson synd... |
DB01080 | DB01501 | 855 | 1,118 | [
"DDInter1933",
"DDInter549"
] | Vigabatrin | Difenoxin | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
855,
24,
1118
]
],
[
[
855,
24,
1688
],
[
1688,
40,
1118
]
],
[
[
855,
63,
506
],
[
506,
24,
1118
]
],
[
[
855,
24,
1609
],
[
1609,
... | [
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenoxylate"
],
[
... | Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Difenoxin (Compound)
Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate inter... |
DB04835 | DB12015 | 1,655 | 1,033 | [
"DDInter1125",
"DDInter53"
] | Maraviroc | Alpelisib | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1655,
24,
1033
]
],
[
[
1655,
24,
951
],
[
951,
24,
1033
]
],
[
[
1655,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
1655,
63,
322
],
[
322,
... | [
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[
... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Maraviroc may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may c... |
DB01068 | DB12332 | 1,565 | 1,619 | [
"DDInter411",
"DDInter1626"
] | Clonazepam | Rucaparib | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1565,
24,
1619
]
],
[
[
1565,
24,
222
],
[
222,
23,
1619
]
],
[
[
1565,
24,
259
],
[
259,
24,
1619
]
],
[
[
1565,
63,
1419
],
[
1419,
... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonac... |
DB01181 | DB16627 | 1,532 | 1,125 | [
"DDInter906",
"DDInter1145"
] | Ifosfamide | Melphalan flufenamide | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. _In vitro_ models show that melphalan is 10 to hundreds of times more potent than melphala... | Moderate | 1 | [
[
[
1532,
24,
1125
]
],
[
[
1532,
63,
611
],
[
611,
24,
1125
]
],
[
[
1532,
63,
611
],
[
611,
63,
147
],
[
147,
24,
1125
]
],
[
[
1532,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan flufenamide"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine and Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan flufenamide
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Dacarbaz... |
DB00284 | DB12015 | 1,647 | 1,033 | [
"DDInter11",
"DDInter53"
] | Acarbose | Alpelisib | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1647,
24,
1033
]
],
[
[
1647,
24,
154
],
[
154,
24,
1033
]
],
[
[
1647,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
1647,
23,
126
],
[
126,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
"... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Acarbose may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause... |
DB00384 | DB01143 | 1,275 | 923 | [
"DDInter1859",
"DDInter65"
] | Triamterene | Amifostine | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1275,
24,
923
]
],
[
[
1275,
21,
28778
],
[
28778,
60,
923
]
],
[
[
1275,
24,
714
],
[
714,
24,
923
]
],
[
[
1275,
24,
885
],
[
885,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Triamterene",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
"{u} (... | Triamterene (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Amifostine (Compound)
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when ta... |
DB00213 | DB00214 | 837 | 1,028 | [
"DDInter1388",
"DDInter1836"
] | Pantoprazole | Torasemide | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Moderate | 1 | [
[
[
837,
24,
1028
]
],
[
[
837,
6,
6017
],
[
6017,
45,
1028
]
],
[
[
837,
21,
28931
],
[
28931,
60,
1028
]
],
[
[
837,
24,
1347
],
[
1347,... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Torasemide"
]
],
[
[
"Pantoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Pantoprazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Torasemide (Compound)
Pantoprazole (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Torasemide (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Clopidogr... |
DB00816 | DB14881 | 1,674 | 180 | [
"DDInter1346",
"DDInter1329"
] | Orciprenaline | Oliceridine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
1674,
24,
180
]
],
[
[
1674,
24,
401
],
[
401,
24,
180
]
],
[
[
1674,
63,
618
],
[
618,
24,
180
]
],
[
[
1674,
35,
1148
],
[
1148,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Abarelix a... |
DB00889 | DB08820 | 1,133 | 1,478 | [
"DDInter840",
"DDInter997"
] | Granisetron | Ivacaftor | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1133,
24,
1478
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1133,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1133,
62,
307
],
[
30... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Granisetron (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafini... |
DB06701 | DB09080 | 1,177 | 144 | [
"DDInter521",
"DDInter1331"
] | Dexmethylphenidate | Olodaterol | Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer s... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1177,
24,
144
]
],
[
[
1177,
40,
895
],
[
895,
24,
144
]
],
[
[
1177,
63,
1445
],
[
1445,
24,
144
]
],
[
[
1177,
24,
468
],
[
468,
... | [
[
[
"Dexmethylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Dexmethylphenidate",
"{u} (Compound) resembles {v} (Compound)",
"Methylphenidate"
],
[
"Methylphenidate",
... | Dexmethylphenidate (Compound) resembles Methylphenidate (Compound) and Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Dexmethylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cau... |
DB01128 | DB01175 | 918 | 318 | [
"DDInter204",
"DDInter672"
] | Bicalutamide | Escitalopram | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Major | 2 | [
[
[
918,
25,
318
]
],
[
[
918,
64,
1230
],
[
1230,
1,
318
]
],
[
[
918,
6,
8374
],
[
8374,
45,
318
]
],
[
[
918,
21,
29276
],
[
29276,
... | [
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
]
],
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
],
[
"Citalopram",
... | Bicalutamide may lead to a major life threatening interaction when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Bicalutamide (Compound) causes Haemoglobin (Side Effect) and Haemoglobin ... |
DB00531 | DB00631 | 450 | 372 | [
"DDInter456",
"DDInter405"
] | Cyclophosphamide | Clofarabine | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
450,
24,
372
]
],
[
[
450,
64,
1064
],
[
1064,
25,
372
]
],
[
[
450,
21,
29217
],
[
29217,
60,
372
]
],
[
[
450,
62,
1467
],
[
1467,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Cyclophosphamide may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Cyclophosphamide (Compound) causes Pericarditis (Side Effect) and Pericarditis (Side Effect) is caused by Clofarabine (Compound)
Cyclop... |
DB08816 | DB08827 | 578 | 990 | [
"DDInter1802",
"DDInter1085"
] | Ticagrelor | Lomitapide | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
578,
24,
990
]
],
[
[
578,
64,
1080
],
[
1080,
1,
990
]
],
[
[
578,
6,
8374
],
[
8374,
45,
990
]
],
[
[
578,
54,
19133
],
[
19133,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Ticagrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan... | Ticagrelor may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Ticagrelor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Ticagrelor (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Cla... |
DB00407 | DB06441 | 202 | 936 | [
"DDInter115",
"DDInter283"
] | Ardeparin | Cangrelor | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Major | 2 | [
[
[
202,
25,
936
]
],
[
[
202,
25,
477
],
[
477,
24,
936
]
],
[
[
202,
63,
305
],
[
305,
24,
936
]
],
[
[
202,
24,
738
],
[
738,
63,... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cangrelor"
]
],
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
],
[
"Cilostazol",
"{u} may ... | Ardeparin may lead to a major life threatening interaction when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Aspar... |
DB00041 | DB08946 | 1,648 | 512 | [
"DDInter38",
"DDInter962"
] | Aldesleukin | Iopanoic acid | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
1648,
24,
512
]
],
[
[
1648,
24,
1428
],
[
1428,
24,
512
]
],
[
[
1648,
24,
777
],
[
777,
63,
512
]
],
[
[
1648,
25,
497
],
[
497,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide and Io... |
DB00252 | DB06168 | 362 | 1,531 | [
"DDInter1460",
"DDInter281"
] | Phenytoin | Canakinumab | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
362,
24,
1531
]
],
[
[
362,
25,
1362
],
[
1362,
63,
1531
]
],
[
[
362,
24,
970
],
[
970,
24,
1531
]
],
[
[
362,
25,
1213
],
[
1213,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
"Olaparib",
... | Phenytoin may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil and Fluorouracil may cause a... |
DB09472 | DB11113 | 1,383 | 657 | [
"DDInter1693",
"DDInter307"
] | Sodium sulfate | Castor oil | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1383,
24,
657
]
],
[
[
1383,
63,
1079
],
[
1079,
24,
657
]
],
[
[
1383,
24,
927
],
[
927,
63,
657
]
],
[
[
1383,
64,
540
],
[
540,
... | [
[
[
"Sodium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Sodium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
... | Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib a... |
DB00637 | DB11113 | 1,557 | 657 | [
"DDInter128",
"DDInter307"
] | Astemizole | Castor oil | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1557,
24,
657
]
],
[
[
1557,
24,
1079
],
[
1079,
24,
657
]
],
[
[
1557,
24,
927
],
[
927,
63,
657
]
],
[
[
1557,
25,
540
],
[
540,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encor... |
DB00881 | DB06792 | 954 | 1,606 | [
"DDInter1554",
"DDInter1023"
] | Quinapril | Lanthanum carbonate | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
954,
24,
1606
]
],
[
[
954,
40,
610
],
[
610,
24,
1606
]
],
[
[
954,
63,
1545
],
[
1545,
24,
1606
]
],
[
[
954,
24,
1487
],
[
1487,
... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Quinapril",
"{u} (Compound) resembles {v} (Compound)",
"Enalapril"
],
[
"Enalapril",
"{u} may cause a mo... | Quinapril (Compound) resembles Enalapril (Compound) and Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline may cause a moderate interac... |
DB00683 | DB00835 | 1,382 | 100 | [
"DDInter1212",
"DDInter245"
] | Midazolam | Brompheniramine | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1382,
24,
100
]
],
[
[
1382,
24,
832
],
[
832,
24,
100
]
],
[
[
1382,
63,
128
],
[
128,
24,
100
]
],
[
[
1382,
24,
649
],
[
649,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphe... |
DB00712 | DB08875 | 1,274 | 1,618 | [
"DDInter764",
"DDInter262"
] | Flurbiprofen (ophthalmic) | Cabozantinib | Flurbiprofen can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
1274,
37,
1618
]
],
[
[
1274,
63,
723
],
[
723,
24,
1618
]
],
[
[
1274,
24,
384
],
[
384,
63,
1618
]
],
[
[
1274,
24,
850
],
[
850,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Flurbiprofen may lead to a major life threatening interaction when taken with Cabozantinib
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant ... |
DB00494 | DB01176 | 1,533 | 537 | [
"DDInter646",
"DDInter453"
] | Entacapone | Cyclizine | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1533,
24,
537
]
],
[
[
1533,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1533,
24,
104
],
[
104,
1,
537
]
],
[
[
1533,
21,
29058
],
[
29058,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methd... |
DB08916 | DB09122 | 26 | 1,613 | [
"DDInter32",
"DDInter1409"
] | Afatinib | Peginterferon beta-1a | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
26,
24,
1613
]
],
[
[
26,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
26,
24,
1155
],
[
1155,
63,
1613
]
],
[
[
26,
63,
651
],
[
651,
... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Tucatinib an... |
DB01232 | DB08899 | 1,327 | 129 | [
"DDInter1640",
"DDInter649"
] | Saquinavir | Enzalutamide | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1327,
25,
129
]
],
[
[
1327,
64,
918
],
[
918,
1,
129
]
],
[
[
1327,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1327,
21,
29377
],
[
29377,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Saquinavir may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Saquinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Saquinavir (Compound) causes Musculoskeletal pain (Side Effect) and Muscu... |
DB00331 | DB00533 | 1,645 | 1,416 | [
"DDInter1164",
"DDInter1613"
] | Metformin | Rofecoxib | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Moderate | 1 | [
[
[
1645,
24,
1416
]
],
[
[
1645,
24,
1144
],
[
1144,
63,
1416
]
],
[
[
1645,
63,
1560
],
[
1560,
24,
1416
]
],
[
[
1645,
24,
91
],
[
91,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rofecoxib"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegas... |
DB00060 | DB08881 | 912 | 868 | [
"DDInter947",
"DDInter1925"
] | Interferon beta-1a | Vemurafenib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
912,
24,
868
]
],
[
[
912,
24,
1247
],
[
1247,
23,
868
]
],
[
[
912,
24,
1204
],
[
1204,
24,
868
]
],
[
[
912,
24,
564
],
[
564,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfametho... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken... |
DB00795 | DB00798 | 50 | 1,132 | [
"DDInter1725",
"DDInter815"
] | Sulfasalazine | Gentamicin | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
50,
24,
1132
]
],
[
[
50,
18,
5415
],
[
5415,
57,
1132
]
],
[
[
50,
63,
1252
],
[
1252,
23,
1132
]
],
[
[
50,
24,
361
],
[
361,
... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Sulfasalazine",
"{u} (Compound) downregulates {v} (Gene)",
"UBQLN2"
],
[
"UBQLN2",
"{u} (Gene) is downregulat... | Sulfasalazine (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Gentamicin (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Gentamicin
Sulf... |
DB00060 | DB08865 | 912 | 1,593 | [
"DDInter947",
"DDInter448"
] | Interferon beta-1a | Crizotinib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
912,
24,
1593
]
],
[
[
912,
24,
283
],
[
283,
62,
1593
]
],
[
[
912,
24,
1247
],
[
1247,
23,
1593
]
],
[
[
912,
24,
883
],
[
883,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Crizotinib
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sulfame... |
DB04953 | DB09268 | 495 | 1,662 | [
"DDInter708",
"DDInter1464"
] | Ezogabine | Picosulfuric acid | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
495,
24,
1662
]
],
[
[
495,
24,
484
],
[
484,
63,
1662
]
],
[
[
495,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
495,
24,
1491
],
[
1491,
... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Ezogabine may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib... |
DB00604 | DB01611 | 1,425 | 1,487 | [
"DDInter385",
"DDInter893"
] | Cisapride | Hydroxychloroquine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1425,
25,
1487
]
],
[
[
1425,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
1425,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1425,
7,
2216
],
[
22... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Cisapride may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Cisapride (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Cisapride (Compound) upregulates P... |
DB01255 | DB09078 | 633 | 1,228 | [
"DDInter1078",
"DDInter1036"
] | Lisdexamfetamine | Lenvatinib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
633,
24,
1228
]
],
[
[
633,
62,
112
],
[
112,
23,
1228
]
],
[
[
633,
63,
609
],
[
609,
24,
1228
]
],
[
[
633,
24,
1151
],
[
1151,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Clarith... |
DB00270 | DB11126 | 1,428 | 900 | [
"DDInter993",
"DDInter276"
] | Isradipine | Calcium gluconate | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
1428,
24,
900
]
],
[
[
1428,
1,
336
],
[
336,
24,
900
]
],
[
[
1428,
40,
854
],
[
854,
24,
900
]
],
[
[
1428,
1,
336
],
[
336,
4... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Isradipine",
"{u} (Compound) resembles {v} (Compound)",
"Nifedipine"
],
[
"Nifedipine",
"{u} may cause a ... | Isradipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Isradipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Calc... |
DB00586 | DB01115 | 1,512 | 336 | [
"DDInter537",
"DDInter1291"
] | Diclofenac | Nifedipine | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
1512,
24,
336
]
],
[
[
1512,
63,
1428
],
[
1428,
1,
336
]
],
[
[
1512,
24,
1081
],
[
1081,
40,
336
]
],
[
[
1512,
24,
409
],
[
409,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compound... |
DB00455 | DB00872 | 1,601 | 1,080 | [
"DDInter1091",
"DDInter438"
] | Loratadine | Conivaptan | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Moderate | 1 | [
[
[
1601,
24,
1080
]
],
[
[
1601,
6,
8374
],
[
8374,
45,
1080
]
],
[
[
1601,
21,
28769
],
[
28769,
60,
1080
]
],
[
[
1601,
24,
1419
],
[
1... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
]
],
[
[
"Loratadine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Loratadine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Conivaptan (Compound)
Loratadine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Conivaptan (Compound)
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Imati... |
DB00046 | DB00218 | 1,179 | 1,176 | [
"DDInter940",
"DDInter1247"
] | Insulin lispro | Moxifloxacin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Major | 2 | [
[
[
1179,
25,
1176
]
],
[
[
1179,
25,
945
],
[
945,
40,
1176
]
],
[
[
1179,
24,
549
],
[
549,
63,
1176
]
],
[
[
1179,
63,
305
],
[
305,
... | [
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
]
],
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfloxacin"... | Insulin lispro may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Moxifloxacin (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that ... |
DB06589 | DB13074 | 1,250 | 877 | [
"DDInter1400",
"DDInter1110"
] | Pazopanib | Macimorelin | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1250,
25,
877
]
],
[
[
1250,
62,
112
],
[
112,
23,
877
]
],
[
[
1250,
24,
1320
],
[
1320,
24,
877
]
],
[
[
1250,
63,
651
],
[
651,
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagoli... |
DB00361 | DB08875 | 134 | 1,618 | [
"DDInter1939",
"DDInter262"
] | Vinorelbine | Cabozantinib | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
134,
24,
1618
]
],
[
[
134,
24,
112
],
[
112,
23,
1618
]
],
[
[
134,
24,
723
],
[
723,
24,
1618
]
],
[
[
134,
25,
384
],
[
384,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant an... |
DB00222 | DB00460 | 245 | 612 | [
"DDInter825",
"DDInter1929"
] | Glimepiride | Verteporfin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
245,
24,
612
]
],
[
[
245,
21,
28762
],
[
28762,
60,
612
]
],
[
[
245,
40,
959
],
[
959,
63,
612
]
],
[
[
245,
24,
820
],
[
820,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cau... | Glimepiride (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Verteporfin (Compound)
Glimepiride (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin
Glimepiride may cause a moderate interaction... |
DB00263 | DB00731 | 1,029 | 1,144 | [
"DDInter1727",
"DDInter1269"
] | Sulfisoxazole | Nateglinide | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
1029,
24,
1144
]
],
[
[
1029,
6,
6017
],
[
6017,
45,
1144
]
],
[
[
1029,
1,
1247
],
[
1247,
63,
1144
]
],
[
[
1029,
63,
305
],
[
305,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Sulfisoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Comp... | Sulfisoxazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nateglinide (Compound)
Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Sulfisoxazole may cause a moderate interaction... |
DB01404 | DB11827 | 757 | 433 | [
"DDInter820",
"DDInter669"
] | Ginseng | Ertugliflozin | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
757,
24,
433
]
],
[
[
757,
63,
959
],
[
959,
24,
433
]
],
[
[
757,
24,
1296
],
[
1296,
24,
433
]
],
[
[
757,
63,
959
],
[
959,
6... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insul... |
DB08864 | DB11837 | 786 | 1,297 | [
"DDInter1595",
"DDInter1351"
] | Rilpivirine | Osilodrostat | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
786,
24,
1297
]
],
[
[
786,
62,
112
],
[
112,
23,
1297
]
],
[
[
786,
24,
1320
],
[
1320,
63,
1297
]
],
[
[
786,
63,
353
],
[
353,
... | [
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Rilpivirine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Rilpivirine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and El... |
DB06822 | DB09293 | 802 | 116 | [
"DDInter1812",
"DDInter954"
] | Tinzaparin | Iodide I-131 | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
802,
24,
116
]
],
[
[
802,
24,
1004
],
[
1004,
63,
116
]
],
[
[
802,
64,
365
],
[
365,
24,
116
]
],
[
[
802,
25,
498
],
[
498,
2... | [
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
],... | Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Tinzaparin may lead to a major life threatening interaction when taken with Dalteparin and Dalte... |
DB00994 | DB06590 | 361 | 1,682 | [
"DDInter1277",
"DDInter329"
] | Neomycin | Ceftaroline fosamil | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia. | Moderate | 1 | [
[
[
361,
24,
1682
]
],
[
[
361,
63,
149
],
[
149,
40,
1682
]
],
[
[
361,
63,
778
],
[
778,
1,
1682
]
],
[
[
361,
24,
1453
],
[
1453,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftaroline fosamil"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftazidime"
],
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Ceftaroline fosamil (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefixime and Cefixime (Compound) resembles Ceftaroline fosamil... |
DB00640 | DB01169 | 1,585 | 57 | [
"DDInter31",
"DDInter120"
] | Adenosine | Arsenic trioxide | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1585,
25,
57
]
],
[
[
1585,
24,
1559
],
[
1559,
24,
57
]
],
[
[
1585,
24,
1616
],
[
1616,
64,
57
]
],
[
[
1585,
25,
1154
],
[
1154,
... | [
[
[
"Adenosine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Adenosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
],
[
"Famoti... | Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and His... |
DB00773 | DB00827 | 896 | 646 | [
"DDInter702",
"DDInter383"
] | Etoposide | Cinoxacin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Minor | 0 | [
[
[
896,
23,
646
]
],
[
[
896,
21,
28691
],
[
28691,
60,
646
]
],
[
[
896,
24,
77
],
[
77,
62,
646
]
],
[
[
896,
63,
322
],
[
322,
2... | [
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
]
],
[
[
"Etoposide",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is caused ... | Etoposide (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cinoxacin (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
... |
DB00214 | DB01284 | 1,028 | 1,042 | [
"DDInter1836",
"DDInter1782"
] | Torasemide | Tetracosactide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1028,
24,
1042
]
],
[
[
1028,
24,
455
],
[
455,
23,
1042
]
],
[
[
1028,
24,
659
],
[
659,
62,
1042
]
],
[
[
1028,
24,
761
],
[
761,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vila... |
DB00041 | DB04946 | 1,648 | 924 | [
"DDInter38",
"DDInter907"
] | Aldesleukin | Iloperidone | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
1648,
24,
924
]
],
[
[
1648,
24,
1664
],
[
1664,
1,
924
]
],
[
[
1648,
24,
519
],
[
519,
40,
924
]
],
[
[
1648,
24,
1214
],
[
1214,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone (... |
DB00031 | DB01175 | 20 | 318 | [
"DDInter1764",
"DDInter672"
] | Tenecteplase | Escitalopram | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
20,
24,
318
]
],
[
[
20,
24,
1230
],
[
1230,
1,
318
]
],
[
[
20,
25,
834
],
[
834,
24,
318
]
],
[
[
20,
24,
714
],
[
714,
24,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Tenecteplase may lead to a major life threatening interaction when taken with Drotrecogin alfa and Drotrecogin alfa may cause a moderate interaction that co... |
DB00757 | DB06204 | 1,166 | 768 | [
"DDInter581",
"DDInter1746"
] | Dolasetron | Tapentadol | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Major | 2 | [
[
[
1166,
25,
768
]
],
[
[
1166,
6,
17589
],
[
17589,
45,
768
]
],
[
[
1166,
21,
29081
],
[
29081,
60,
768
]
],
[
[
1166,
25,
1383
],
[
13... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tapentadol"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"HTR3A"
],
[
"HTR3A",
"{u} (Gene) is bound by {v} (Compound)",
"Tapentado... | Dolasetron (Compound) binds HTR3A (Gene) and HTR3A (Gene) is bound by Tapentadol (Compound)
Dolasetron (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Tapentadol (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Sodium sulfate and Sodium sulfate ... |
DB06292 | DB14731 | 549 | 1,518 | [
"DDInter474",
"DDInter1741"
] | Dapagliflozin | Tagraxofusp | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
549,
24,
1518
]
],
[
[
549,
63,
176
],
[
176,
24,
1518
]
],
[
[
549,
24,
850
],
[
850,
24,
1518
]
],
[
[
549,
1,
1344
],
[
1344,
... | [
[
[
"Dapagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Dapagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
... | Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Br... |
DB00675 | DB00704 | 888 | 267 | [
"DDInter1744",
"DDInter1263"
] | Tamoxifen | Naltrexone | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
888,
24,
267
]
],
[
[
888,
6,
4973
],
[
4973,
45,
267
]
],
[
[
888,
7,
3163
],
[
3163,
46,
267
]
],
[
[
888,
18,
6797
],
[
6797,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Tamoxifen",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Naltrexone (Compound)
Tamoxifen (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Naltrexone (Compound)
Tamoxifen (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Naltrexone (Compound)
Tamoxifen (Compou... |
DB00860 | DB08904 | 891 | 375 | [
"DDInter1513",
"DDInter342"
] | Prednisolone | Certolizumab pegol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
891,
25,
375
]
],
[
[
891,
62,
1461
],
[
1461,
23,
375
]
],
[
[
891,
23,
1193
],
[
1193,
62,
375
]
],
[
[
891,
24,
200
],
[
200,
... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"V... | Prednisolone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate an... |
DB00188 | DB01229 | 168 | 973 | [
"DDInter222",
"DDInter1378"
] | Bortezomib | Paclitaxel (protein-bound) | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
168,
24,
973
]
],
[
[
168,
24,
310
],
[
310,
63,
973
]
],
[
[
168,
6,
8374
],
[
8374,
45,
973
]
],
[
[
168,
18,
7824
],
[
7824,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Bortezom... |
DB06710 | DB08880 | 1,546 | 1,510 | [
"DDInter1193",
"DDInter1771"
] | Methyltestosterone | Teriflunomide | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1546,
25,
1510
]
],
[
[
1546,
63,
1144
],
[
1144,
24,
1510
]
],
[
[
1546,
1,
303
],
[
303,
24,
1510
]
],
[
[
1546,
40,
1197
],
[
1197,... | [
[
[
"Methyltestosterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Methyltestosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Methyltestosterone (Compound) resembles Medroxyprogesterone acetate (Compound) and Medroxyprogester... |
DB00970 | DB08895 | 0 | 976 | [
"DDInter466",
"DDInter1825"
] | Dactinomycin | Tofacitinib | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
0,
25,
976
]
],
[
[
0,
63,
1461
],
[
1461,
23,
976
]
],
[
[
0,
24,
214
],
[
214,
63,
976
]
],
[
[
0,
24,
1430
],
[
1430,
24,
... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fos... |
DB04855 | DB11979 | 540 | 1,320 | [
"DDInter602",
"DDInter625"
] | Dronedarone | Elagolix | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
540,
24,
1320
]
],
[
[
540,
63,
608
],
[
608,
23,
1320
]
],
[
[
540,
25,
1297
],
[
1297,
24,
1320
]
],
[
[
540,
64,
79
],
[
79,
... | [
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Elagolix
Dronedarone may lead to a major life threatening interaction when taken with Osilodrostat and Osilodrostat may cause ... |
DB00402 | DB08865 | 1,407 | 1,593 | [
"DDInter685",
"DDInter448"
] | Eszopiclone | Crizotinib | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1407,
24,
1593
]
],
[
[
1407,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1407,
21,
29093
],
[
29093,
60,
1593
]
],
[
[
1407,
24,
283
],
[
28... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Eszopiclone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Eszopiclone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Eszopiclone (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedra... |
DB00308 | DB09020 | 347 | 28 | [
"DDInter901",
"DDInter212"
] | Ibutilide | Bisacodyl | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
347,
24,
28
]
],
[
[
347,
21,
28789
],
[
28789,
60,
28
]
],
[
[
347,
40,
540
],
[
540,
24,
28
]
],
[
[
347,
25,
823
],
[
823,
63... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
"{u} ... | Ibutilide (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Bisacodyl (Compound)
Ibutilide (Compound) resembles Dronedarone (Compound) and Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Ibutilide may lead to ... |
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