drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01246 | DB06203 | 820 | 1,002 | [
"DDInter45",
"DDInter51"
] | Alimemazine | Alogliptin | A phenothiazine derivative that is used as an antipruritic. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
820,
24,
1002
]
],
[
[
820,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
820,
6,
8374
],
[
8374,
45,
1002
]
],
[
[
820,
21,
28787
],
[
28787,... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Alimemazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alogliptin (Compound)
Alimemazine (Compound) causes Dermatitis (Side Effect) and Der... |
DB00584 | DB11130 | 610 | 407 | [
"DDInter638",
"DDInter1344"
] | Enalapril | Opium | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
610,
24,
407
]
],
[
[
610,
24,
104
],
[
104,
24,
407
]
],
[
[
610,
63,
1314
],
[
1314,
24,
407
]
],
[
[
610,
1,
1058
],
[
1058,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
"... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopr... |
DB00615 | DB12332 | 690 | 1,619 | [
"DDInter1589",
"DDInter1626"
] | Rifabutin | Rucaparib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
690,
24,
1619
]
],
[
[
690,
24,
112
],
[
112,
23,
1619
]
],
[
[
690,
24,
309
],
[
309,
24,
1619
]
],
[
[
690,
25,
1419
],
[
1419,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixab... |
DB01193 | DB09132 | 819 | 492 | [
"DDInter12",
"DDInter797"
] | Acebutolol | Gadoteric acid | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA). It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). Gadoterate meglumine has one o... | Moderate | 1 | [
[
[
819,
24,
492
]
],
[
[
819,
40,
88
],
[
88,
24,
492
]
],
[
[
819,
40,
88
],
[
88,
40,
17
],
[
17,
24,
492
]
],
[
[
819,
40,
... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoteric acid"
]
],
[
[
"Acebutolol",
"{u} (Compound) resembles {v} (Compound)",
"Metoprolol"
],
[
"Metoprolol",
"{u} may cause a mod... | Acebutolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Gadoteric acid
Acebutolol (Compound) resembles Metoprolol (Compound) and Metoprolol (Compound) resembles Sotalol (Compound) and Sotalol may cause a moderate interaction th... |
DB00081 | DB01242 | 273 | 1,237 | [
"DDInter1838",
"DDInter410"
] | Tositumomab | Clomipramine | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
273,
24,
1237
]
],
[
[
273,
64,
1578
],
[
1578,
24,
1237
]
],
[
[
273,
25,
710
],
[
710,
63,
1237
]
],
[
[
273,
37,
1274
],
[
1274,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirud... | Tositumomab may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine
Tositumomab may lead to a major life threatening interaction when taken with Binimetinib and Binimetinib may cause a moderate ... |
DB00704 | DB00712 | 267 | 1,274 | [
"DDInter1263",
"DDInter763"
] | Naltrexone | Flurbiprofen | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
267,
24,
1274
]
],
[
[
267,
24,
935
],
[
935,
63,
1274
]
],
[
[
267,
63,
1523
],
[
1523,
24,
1274
]
],
[
[
267,
6,
15705
],
[
15705,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labet... |
DB00283 | DB04843 | 701 | 1,511 | [
"DDInter395",
"DDInter1149"
] | Clemastine | Mepenzolate | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
701,
35,
1511
]
],
[
[
701,
25,
675
],
[
675,
24,
1511
]
],
[
[
701,
24,
537
],
[
537,
24,
1511
]
],
[
[
701,
63,
352
],
[
352,
... | [
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Clemastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Clemastine (Compound) resembles Mepenzolate (Compound) and
Clemastine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Clemastine may cause a moderate interaction that co... |
DB00860 | DB01263 | 891 | 859 | [
"DDInter1513",
"DDInter1494"
] | Prednisolone | Posaconazole | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
891,
24,
859
]
],
[
[
891,
6,
4973
],
[
4973,
45,
859
]
],
[
[
891,
21,
28762
],
[
28762,
60,
859
]
],
[
[
891,
63,
1101
],
[
1101,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Prednisolone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Prednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Prednisolone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene an... |
DB00533 | DB00758 | 1,416 | 1,347 | [
"DDInter1613",
"DDInter413"
] | Rofecoxib | Clopidogrel | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
1416,
24,
1347
]
],
[
[
1416,
63,
1018
],
[
1018,
25,
1347
]
],
[
[
1416,
24,
1411
],
[
1411,
62,
1347
]
],
[
[
1416,
63,
245
],
[
245... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cau... |
DB00916 | DB06273 | 112 | 980 | [
"DDInter1202",
"DDInter1824"
] | Metronidazole | Tocilizumab | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
112,
24,
980
]
],
[
[
112,
62,
494
],
[
494,
24,
980
]
],
[
[
112,
24,
309
],
[
309,
24,
980
]
],
[
[
112,
24,
110
],
[
110,
63,... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Disopyramide"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Disopyramide and Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone ... |
DB00081 | DB00461 | 273 | 598 | [
"DDInter1838",
"DDInter1254"
] | Tositumomab | Nabumetone | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Major | 2 | [
[
[
273,
25,
598
]
],
[
[
273,
64,
1271
],
[
1271,
24,
598
]
],
[
[
273,
25,
1259
],
[
1259,
63,
598
]
],
[
[
273,
25,
1061
],
[
1061,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nabumetone"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alteplase"
],
[
"Alteplase",
"{u} m... | Tositumomab may lead to a major life threatening interaction when taken with Alteplase and Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone
Tositumomab may lead to a major life threatening interaction when taken with Baricitinib and Baricitinib may cause a moderate in... |
DB00400 | DB11581 | 353 | 1,456 | [
"DDInter843",
"DDInter1926"
] | Griseofulvin | Venetoclax | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
353,
24,
1456
]
],
[
[
353,
24,
1135
],
[
1135,
23,
1456
]
],
[
[
353,
24,
536
],
[
536,
24,
1456
]
],
[
[
353,
24,
1476
],
[
1476,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Seco... |
DB00254 | DB00277 | 964 | 1,031 | [
"DDInter598",
"DDInter1791"
] | Doxycycline | Theophylline | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Moderate | 1 | [
[
[
964,
24,
1031
]
],
[
[
964,
6,
8374
],
[
8374,
45,
1031
]
],
[
[
964,
24,
1096
],
[
1096,
62,
1031
]
],
[
[
964,
24,
759
],
[
759,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
]
],
[
[
"Doxycycline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Theophylline (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Theophylline
... |
DB00252 | DB00284 | 362 | 1,647 | [
"DDInter1460",
"DDInter11"
] | Phenytoin | Acarbose | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
362,
24,
1647
]
],
[
[
362,
21,
29047
],
[
29047,
60,
1647
]
],
[
[
362,
24,
1645
],
[
1645,
62,
1647
]
],
[
[
362,
24,
417
],
[
417,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Phenytoin",
"{u} (Compound) causes {v} (Side Effect)",
"Hepatic function abnormal"
],
[
"Hepatic function abnormal",
... | Phenytoin (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Acarbose (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a minor interaction that can limit clinical effects... |
DB00907 | DB06701 | 290 | 1,177 | [
"DDInter427",
"DDInter521"
] | Cocaine (topical) | Dexmethylphenidate | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer s... | Major | 2 | [
[
[
290,
25,
1177
]
],
[
[
290,
64,
895
],
[
895,
1,
1177
]
],
[
[
290,
40,
19
],
[
19,
40,
1177
]
],
[
[
290,
40,
85
],
[
85,
1,
... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexmethylphenidate"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylphenidate"
],
[
"Methylphenidate",
... | Cocaine may lead to a major life threatening interaction when taken with Dexmethylphenidate
Cocaine may lead to a major life threatening interaction when taken with Methylphenidate and Methylphenidate (Compound) resembles Dexmethylphenidate (Compound)
Cocaine (Compound) resembles Hyoscyamine (Compound) and Hyoscyamine ... |
DB00496 | DB09039 | 194 | 1,670 | [
"DDInter480",
"DDInter629"
] | Darifenacin | Eliglustat | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
194,
25,
1670
]
],
[
[
194,
24,
121
],
[
121,
24,
1670
]
],
[
[
194,
63,
597
],
[
597,
24,
1670
]
],
[
[
194,
40,
1413
],
[
1413,
... | [
[
[
"Darifenacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
[
"Fenflu... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol... |
DB00163 | DB01168 | 1,461 | 1,053 | [
"DDInter1943",
"DDInter1526"
] | Vitamin E | Procarbazine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1461,
24,
1053
]
],
[
[
1461,
24,
126
],
[
126,
23,
1053
]
],
[
[
1461,
23,
1683
],
[
1683,
63,
1053
]
],
[
[
1461,
62,
1184
],
[
1184... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab and Ustekinumab m... |
DB01004 | DB06595 | 563 | 1,491 | [
"DDInter806",
"DDInter1214"
] | Ganciclovir | Midostaurin | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
563,
24,
1491
]
],
[
[
563,
24,
1342
],
[
1342,
24,
1491
]
],
[
[
563,
63,
663
],
[
663,
24,
1491
]
],
[
[
563,
24,
738
],
[
738,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
],
[... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and M... |
DB00398 | DB04953 | 79 | 495 | [
"DDInter1702",
"DDInter708"
] | Sorafenib | Ezogabine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
79,
24,
495
]
],
[
[
79,
6,
15705
],
[
15705,
45,
495
]
],
[
[
79,
21,
28787
],
[
28787,
60,
495
]
],
[
[
79,
23,
1135
],
[
1135,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"UGT1A1"
],
[
"UGT1A1",
"{u} (Gene) is bound by {v} (Compound)",
... | Sorafenib (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Ezogabine (Compound)
Sorafenib (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ezogabine (Compound)
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol ... |
DB00436 | DB01168 | 323 | 1,053 | [
"DDInter179",
"DDInter1526"
] | Bendroflumethiazide | Procarbazine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
323,
24,
1053
]
],
[
[
323,
24,
848
],
[
848,
40,
1053
]
],
[
[
323,
21,
28784
],
[
28784,
60,
1053
]
],
[
[
323,
23,
126
],
[
126,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprof... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Bendroflumethiazide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Procarbazine (Compound)
Bendroflum... |
DB01175 | DB06603 | 318 | 39 | [
"DDInter672",
"DDInter1387"
] | Escitalopram | Panobinostat | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
318,
25,
39
]
],
[
[
318,
62,
112
],
[
112,
23,
39
]
],
[
[
318,
63,
272
],
[
272,
24,
39
]
],
[
[
318,
64,
506
],
[
506,
24,
... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniram... |
DB00631 | DB14443 | 372 | 987 | [
"DDInter405",
"DDInter1931"
] | Clofarabine | Vibrio cholerae CVD 103-HgR strain live antigen | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
372,
24,
987
]
],
[
[
372,
24,
1480
],
[
1480,
24,
987
]
],
[
[
372,
63,
141
],
[
141,
24,
987
]
],
[
[
372,
1,
1426
],
[
1426,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Clofarabine may cause a moderate interaction that could exacerbate diseases wh... |
DB00375 | DB00635 | 1,037 | 1,573 | [
"DDInter433",
"DDInter1515"
] | Colestipol | Prednisone | Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally o... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
1037,
24,
1573
]
],
[
[
1037,
24,
175
],
[
175,
40,
1573
]
],
[
[
1037,
24,
167
],
[
167,
1,
1573
]
],
[
[
1037,
21,
28957
],
[
28957,... | [
[
[
"Colestipol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Colestipol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Colestipol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Colestipol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Predniso... |
DB00022 | DB00704 | 268 | 267 | [
"DDInter1408",
"DDInter1263"
] | Peginterferon alfa-2b | Naltrexone | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
268,
24,
267
]
],
[
[
268,
24,
522
],
[
522,
24,
267
]
],
[
[
268,
24,
850
],
[
850,
63,
267
]
],
[
[
268,
25,
72
],
[
72,
63,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafir... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00489 | DB11827 | 17 | 433 | [
"DDInter1704",
"DDInter669"
] | Sotalol | Ertugliflozin | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
17,
24,
433
]
],
[
[
17,
24,
959
],
[
959,
24,
433
]
],
[
[
17,
64,
521
],
[
521,
24,
433
]
],
[
[
17,
25,
820
],
[
820,
24,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Sotalol may lead to a major life threatening interaction when taken with Goserelin and Goserelin may cause a moder... |
DB00934 | DB01087 | 413 | 1,520 | [
"DDInter1124",
"DDInter1520"
] | Maprotiline | Primaquine | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
413,
24,
1520
]
],
[
[
413,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
413,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
413,
21,
28722
],
[
2872... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"... | Maprotiline may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Maprotiline (Compound) causes ... |
DB09049 | DB12010 | 1,135 | 214 | [
"DDInter1261",
"DDInter785"
] | Naloxegol | Fostamatinib | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1135,
24,
214
]
],
[
[
1135,
64,
723
],
[
723,
24,
214
]
],
[
[
1135,
63,
690
],
[
690,
24,
214
]
],
[
[
1135,
62,
307
],
[
307,
... | [
[
[
"Naloxegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Naloxegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aprepitant"
],
[
"Aprepitant... | Naloxegol may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a ... |
DB00950 | DB09291 | 1,413 | 741 | [
"DDInter732",
"DDInter1615"
] | Fexofenadine | Rolapitant | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1413,
24,
741
]
],
[
[
1413,
24,
1671
],
[
1671,
24,
741
]
],
[
[
1413,
24,
938
],
[
938,
63,
741
]
],
[
[
1413,
1,
194
],
[
194,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
],
... | Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant and ... |
DB00065 | DB01610 | 581 | 248 | [
"DDInter923",
"DDInter1912"
] | Infliximab | Valganciclovir | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Major | 2 | [
[
[
581,
25,
248
]
],
[
[
581,
25,
563
],
[
563,
1,
248
]
],
[
[
581,
25,
1101
],
[
1101,
24,
248
]
],
[
[
581,
64,
669
],
[
669,
24... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valganciclovir"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ganciclovir"
],
[
"Ganciclovir",
... | Infliximab may lead to a major life threatening interaction when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Infliximab may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases whe... |
DB01764 | DB08820 | 805 | 1,478 | [
"DDInter469",
"DDInter997"
] | Dalfopristin | Ivacaftor | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
805,
25,
1478
]
],
[
[
805,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
805,
25,
1135
],
[
1135,
62,
1478
]
],
[
[
805,
63,
617
],
[
617,
... | [
[
[
"Dalfopristin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Dalfopristin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ivac... | Dalfopristin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Dalfopristin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Ivacaftor
Dalfopristin may cause a moderate i... |
DB06290 | DB13874 | 1,449 | 1,501 | [
"DDInter1673",
"DDInter639"
] | Simeprevir | Enasidenib | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
1449,
24,
1501
]
],
[
[
1449,
63,
72
],
[
72,
24,
1501
]
],
[
[
1449,
25,
1604
],
[
1604,
24,
1501
]
],
[
[
1449,
24,
1510
],
[
1510,
... | [
[
[
"Simeprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Simeprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
],
[
... | Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Simeprevir may lead to a major life threatening interaction when taken with Lumacaftor and Lumacaftor may caus... |
DB00283 | DB00371 | 701 | 1,050 | [
"DDInter395",
"DDInter1154"
] | Clemastine | Meprobamate | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Moderate | 1 | [
[
[
701,
24,
1050
]
],
[
[
701,
24,
210
],
[
210,
1,
1050
]
],
[
[
701,
21,
28741
],
[
28741,
60,
1050
]
],
[
[
701,
24,
222
],
[
222,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meprobamate"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carisoprodol"
],
[... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Carisoprodol and Carisoprodol (Compound) resembles Meprobamate (Compound)
Clemastine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Meprobamate (Compound)
Clemastine may cause a moderate intera... |
DB00773 | DB08889 | 896 | 350 | [
"DDInter702",
"DDInter299"
] | Etoposide | Carfilzomib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
896,
24,
350
]
],
[
[
896,
6,
4973
],
[
4973,
45,
350
]
],
[
[
896,
21,
28762
],
[
28762,
60,
350
]
],
[
[
896,
24,
1270
],
[
1270,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Etoposide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Etoposide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound)
Etoposide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified prot... |
DB01133 | DB06723 | 1,104 | 115 | [
"DDInter1808",
"DDInter58"
] | Tiludronic acid | Aluminum hydroxide | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
1104,
24,
115
]
],
[
[
1104,
24,
428
],
[
428,
63,
115
]
],
[
[
1104,
63,
417
],
[
417,
24,
115
]
],
[
[
1104,
24,
1596
],
[
1596,
... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous f... | Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when ta... |
DB01575 | DB04861 | 1,054 | 1,592 | [
"DDInter1005",
"DDInter1271"
] | Kaolin | Nebivolol | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Minor | 0 | [
[
[
1054,
23,
1592
]
],
[
[
1054,
63,
1123
],
[
1123,
24,
1592
]
],
[
[
1054,
24,
407
],
[
407,
63,
1592
]
],
[
[
1054,
63,
1123
],
[
1123... | [
[
[
"Kaolin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nebivolol"
]
],
[
[
"Kaolin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
],
[
"Pro... | Kaolin may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol
Kaolin may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may caus... |
DB00022 | DB00980 | 268 | 969 | [
"DDInter1408",
"DDInter1564"
] | Peginterferon alfa-2b | Ramelteon | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
268,
24,
969
]
],
[
[
268,
25,
1101
],
[
1101,
24,
969
]
],
[
[
268,
63,
491
],
[
491,
24,
969
]
],
[
[
268,
24,
384
],
[
384,
6... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
... | Peginterferon alfa-2b may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon a... |
DB00686 | DB08901 | 383 | 1,468 | [
"DDInter1424",
"DDInter1492"
] | Pentosan polysulfate | Ponatinib | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
383,
24,
1468
]
],
[
[
383,
21,
28852
],
[
28852,
60,
1468
]
],
[
[
383,
24,
765
],
[
765,
24,
1468
]
],
[
[
383,
24,
330
],
[
330,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Pentosan polysulfate",
"{u} (Compound) causes {v} (Side Effect)",
"Leukopenia"
],
[
"Leukopenia",
"{u} ... | Pentosan polysulfate (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Ponatinib (Compound)
Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00682 | DB00982 | 126 | 1,517 | [
"DDInter1951",
"DDInter991"
] | Warfarin | Isotretinoin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
126,
24,
1517
]
],
[
[
126,
63,
362
],
[
362,
24,
1517
]
],
[
[
126,
24,
868
],
[
868,
63,
1517
]
],
[
[
126,
62,
663
],
[
663,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafen... |
DB00264 | DB00651 | 88 | 746 | [
"DDInter1200",
"DDInter613"
] | Metoprolol | Dyphylline | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Major | 2 | [
[
[
88,
25,
746
]
],
[
[
88,
25,
1031
],
[
1031,
1,
746
]
],
[
[
88,
21,
29118
],
[
29118,
60,
746
]
],
[
[
88,
24,
22
],
[
22,
62,
... | [
[
[
"Metoprolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dyphylline"
]
],
[
[
"Metoprolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Theophylline"
],
[
"Theophylline",
"{... | Metoprolol may lead to a major life threatening interaction when taken with Theophylline and Theophylline (Compound) resembles Dyphylline (Compound)
Metoprolol (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Dyphylline (Compound)
Metoprolol may cause a moderate interaction that co... |
DB09068 | DB12500 | 1,427 | 283 | [
"DDInter1948",
"DDInter714"
] | Vortioxetine | Fedratinib | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1427,
24,
283
]
],
[
[
1427,
63,
885
],
[
885,
24,
283
]
],
[
[
1427,
24,
971
],
[
971,
24,
283
]
],
[
[
1427,
64,
1133
],
[
1133,
... | [
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
... | Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib ... |
DB00222 | DB00612 | 245 | 1,121 | [
"DDInter825",
"DDInter216"
] | Glimepiride | Bisoprolol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
245,
24,
1121
]
],
[
[
245,
24,
819
],
[
819,
40,
1121
]
],
[
[
245,
21,
28681
],
[
28681,
60,
1121
]
],
[
[
245,
24,
417
],
[
417,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Glimepiride (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Bisoprolol (Compound)
Glimepiride may cause a mode... |
DB00472 | DB09268 | 758 | 1,662 | [
"DDInter758",
"DDInter1464"
] | Fluoxetine | Picosulfuric acid | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
758,
24,
1662
]
],
[
[
758,
24,
484
],
[
484,
63,
1662
]
],
[
[
758,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
758,
64,
73
],
[
73,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Fluoxetine may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantin... |
DB01612 | DB08931 | 1,637 | 947 | [
"DDInter92",
"DDInter1600"
] | Amyl Nitrite | Riociguat | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Major | 2 | [
[
[
1637,
25,
947
]
],
[
[
1637,
24,
1344
],
[
1344,
24,
947
]
],
[
[
1637,
25,
1455
],
[
1455,
63,
947
]
],
[
[
1637,
63,
714
],
[
714,
... | [
[
[
"Amyl Nitrite",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Riociguat"
]
],
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
"Cana... | Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Amyl Nitrite may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous ac... |
DB00649 | DB06273 | 231 | 980 | [
"DDInter1710",
"DDInter1824"
] | Stavudine | Tocilizumab | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
231,
24,
980
]
],
[
[
231,
40,
139
],
[
139,
24,
980
]
],
[
[
231,
24,
309
],
[
309,
24,
980
]
],
[
[
231,
24,
850
],
[
850,
63,... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Stavudine",
"{u} (Compound) resembles {v} (Compound)",
"Zidovudine"
],
[
"Zidovudine",
"{u} may cause a moderate... | Stavudine (Compound) resembles Zidovudine (Compound) and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that coul... |
DB00226 | DB00374 | 1,000 | 1,061 | [
"DDInter845",
"DDInter1852"
] | Guanadrel | Treprostinil | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
1000,
24,
1061
]
],
[
[
1000,
24,
885
],
[
885,
40,
1061
]
],
[
[
1000,
24,
1450
],
[
1450,
63,
1061
]
],
[
[
1000,
25,
1214
],
[
1214... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction ... |
DB00834 | DB08820 | 932 | 1,478 | [
"DDInter1215",
"DDInter997"
] | Mifepristone | Ivacaftor | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
932,
24,
1478
]
],
[
[
932,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
932,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
932,
25,
1135
],
[
1135,... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Mifepristone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Mifepristone (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Mifepristone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol ma... |
DB00574 | DB00924 | 121 | 1,405 | [
"DDInter717",
"DDInter454"
] | Fenfluramine | Cyclobenzaprine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Major | 2 | [
[
[
121,
25,
1405
]
],
[
[
121,
63,
1302
],
[
1302,
1,
1405
]
],
[
[
121,
25,
939
],
[
939,
1,
1405
]
],
[
[
121,
24,
1164
],
[
1164,
... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
[
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Cyclobenzaprine (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Benzphetamine and Benzphetamine (Compound) resembles Cyclobenzaprine ... |
DB01244 | DB01259 | 762 | 392 | [
"DDInter192",
"DDInter1024"
] | Bepridil | Lapatinib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
762,
25,
392
]
],
[
[
762,
6,
4973
],
[
4973,
45,
392
]
],
[
[
762,
21,
28695
],
[
28695,
60,
392
]
],
[
[
762,
23,
1135
],
[
1135,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Bepridil",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapatinib"
... | Bepridil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Bepridil (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Lapatinib (Compound)
Bepridil may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause... |
DB09312 | DB10316 | 967 | 334 | [
"DDInter103",
"DDInter1248"
] | Antilymphocyte immunoglobulin (horse) | Mumps virus strain B level jeryl lynn live antigen | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
967,
25,
334
]
],
[
[
967,
64,
1057
],
[
1057,
25,
334
]
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[
[
967,
25,
1011
],
[
1011,
25,
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]
],
[
[
967,
63,
599
],
[
599,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening inte... | Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Antilymphocyte immunoglobulin (horse) may lead to a major life threatening ... |
DB00834 | DB08870 | 932 | 850 | [
"DDInter1215",
"DDInter228"
] | Mifepristone | Brentuximab vedotin | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
932,
24,
850
]
],
[
[
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63,
896
],
[
896,
24,
850
]
],
[
[
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24,
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],
[
1468,
63,
850
]
],
[
[
932,
24,
458
],
[
458,
2... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib ... |
DB00959 | DB01199 | 1,486 | 1,217 | [
"DDInter1191",
"DDInter1890"
] | Methylprednisolone | Tubocurarine | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodend... | Moderate | 1 | [
[
[
1486,
24,
1217
]
],
[
[
1486,
24,
545
],
[
545,
1,
1217
]
],
[
[
1486,
40,
1573
],
[
1573,
24,
1217
]
],
[
[
1486,
63,
1287
],
[
1287,... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurin... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Metocurine and Metocurine (Compound) resembles Tubocurarine (Compound)
Methylprednisolone (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when take... |
DB09078 | DB11057 | 1,228 | 720 | [
"DDInter1036",
"DDInter1223"
] | Lenvatinib | Mineral oil | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1228,
24,
720
]
],
[
[
1228,
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],
[
927,
63,
720
]
],
[
[
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63,
1151
],
[
1151,
24,
720
]
],
[
[
1228,
64,
1069
],
[
1069,
... | [
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Suni... |
DB06772 | DB12130 | 310 | 1,017 | [
"DDInter259",
"DDInter1094"
] | Cabazitaxel | Lorlatinib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
310,
24,
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[
[
310,
63,
1101
],
[
1101,
23,
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],
[
[
310,
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],
[
976,
24,
1017
]
],
[
[
310,
63,
1554
],
[
1554,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Cabazitaxel may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may caus... |
DB00421 | DB00741 | 443 | 167 | [
"DDInter1707",
"DDInter885"
] | Spironolactone | Hydrocortisone | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
443,
24,
167
]
],
[
[
443,
1,
312
],
[
312,
24,
167
]
],
[
[
443,
24,
1220
],
[
1220,
40,
167
]
],
[
[
443,
1,
303
],
[
303,
40,... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Spironolactone",
"{u} (Compound) resembles {v} (Compound)",
"Eplerenone"
],
[
"Eplerenone",
"{u} may cau... | Spironolactone (Compound) resembles Eplerenone (Compound) and Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydr... |
DB00601 | DB01073 | 453 | 1,488 | [
"DDInter1073",
"DDInter745"
] | Linezolid | Fludarabine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
453,
24,
1488
]
],
[
[
453,
21,
29170
],
[
29170,
60,
1488
]
],
[
[
453,
24,
36
],
[
36,
63,
1488
]
],
[
[
453,
63,
522
],
[
522,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Linezolid",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac failure congestive"
],
[
"Cardiac failure congestive",... | Linezolid (Compound) causes Cardiac failure congestive (Side Effect) and Cardiac failure congestive (Side Effect) is caused by Fludarabine (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate dis... |
DB01097 | DB11569 | 1,377 | 1,093 | [
"DDInter1033",
"DDInter1003"
] | Leflunomide | Ixekizumab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Major | 2 | [
[
[
1377,
25,
1093
]
],
[
[
1377,
23,
1114
],
[
1114,
23,
1093
]
],
[
[
1377,
62,
1461
],
[
1461,
23,
1093
]
],
[
[
1377,
64,
66
],
[
66,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
]
],
[
[
"Leflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sul... | Leflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ixekizumab
Leflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin... |
DB08904 | DB15035 | 375 | 503 | [
"DDInter342",
"DDInter1959"
] | Certolizumab pegol | Zanubrutinib | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
375,
25,
503
]
],
[
[
375,
63,
1430
],
[
1430,
24,
503
]
],
[
[
375,
64,
1683
],
[
1683,
24,
503
]
],
[
[
375,
25,
951
],
[
951,
... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
... | Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Certolizumab pegol may lead to a major life threatening interaction when taken with Ustekinumab an... |
DB00687 | DB00705 | 870 | 441 | [
"DDInter747",
"DDInter496"
] | Fludrocortisone | Delavirdine | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
870,
24,
441
]
],
[
[
870,
21,
29488
],
[
29488,
60,
441
]
],
[
[
870,
1,
303
],
[
303,
23,
441
]
],
[
[
870,
1,
1220
],
[
1220,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Rash maculo-papular"
],
[
"Rash maculo-papular",
... | Fludrocortisone (Compound) causes Rash maculo-papular (Side Effect) and Rash maculo-papular (Side Effect) is caused by Delavirdine (Compound)
Fludrocortisone (Compound) resembles Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when tak... |
DB00436 | DB00563 | 323 | 663 | [
"DDInter179",
"DDInter1174"
] | Bendroflumethiazide | Methotrexate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
323,
24,
663
]
],
[
[
323,
18,
10699
],
[
10699,
57,
663
]
],
[
[
323,
21,
29956
],
[
29956,
60,
663
]
],
[
[
323,
23,
126
],
[
126,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) downregulates {v} (Gene)",
"KIF20A"
],
[
"KIF20A",
"{u} (Gene) ... | Bendroflumethiazide (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Methotrexate (Compound)
Bendroflumethiazide (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Methotrexate (Compound)
Bendroflumethiazide may cause a minor interaction ... |
DB00331 | DB08912 | 1,645 | 1,040 | [
"DDInter1164",
"DDInter462"
] | Metformin | Dabrafenib | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1645,
24,
1040
]
],
[
[
1645,
18,
5274
],
[
5274,
46,
1040
]
],
[
[
1645,
6,
10746
],
[
10746,
46,
1040
]
],
[
[
1645,
18,
4729
],
[
4... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Metformin",
"{u} (Compound) downregulates {v} (Gene)",
"PSME1"
],
[
"PSME1",
"{u} (Gene) is upregulated by {v} (C... | Metformin (Compound) downregulates PSME1 (Gene) and PSME1 (Gene) is upregulated by Dabrafenib (Compound)
Metformin (Compound) binds NDUFB5 (Gene) and NDUFB5 (Gene) is upregulated by Dabrafenib (Compound)
Metformin (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dabrafenib (Compound)
Met... |
DB00031 | DB06603 | 20 | 39 | [
"DDInter1764",
"DDInter1387"
] | Tenecteplase | Panobinostat | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
20,
25,
39
]
],
[
[
20,
24,
578
],
[
578,
63,
39
]
],
[
[
20,
24,
383
],
[
383,
24,
39
]
],
[
[
20,
25,
4
],
[
4,
24,
39
... | [
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Tica... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysu... |
DB00188 | DB11793 | 168 | 738 | [
"DDInter222",
"DDInter1297"
] | Bortezomib | Niraparib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
168,
24,
738
]
],
[
[
168,
24,
1033
],
[
1033,
63,
738
]
],
[
[
168,
24,
663
],
[
663,
24,
738
]
],
[
[
168,
63,
1253
],
[
1253,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotr... |
DB00414 | DB01175 | 590 | 318 | [
"DDInter16",
"DDInter672"
] | Acetohexamide | Escitalopram | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
590,
24,
318
]
],
[
[
590,
63,
1230
],
[
1230,
1,
318
]
],
[
[
590,
25,
86
],
[
86,
23,
318
]
],
[
[
590,
63,
168
],
[
168,
23,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Acetohexamide may lead to a major life threatening interaction when taken with Miconazole and Miconazole may cause a minor interaction that can limit clini... |
DB00754 | DB01105 | 157 | 222 | [
"DDInter696",
"DDInter1665"
] | Ethotoin | Sibutramine | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
157,
24,
222
]
],
[
[
157,
21,
28698
],
[
28698,
60,
222
]
],
[
[
157,
24,
384
],
[
384,
62,
222
]
],
[
[
157,
64,
600
],
[
600,
... | [
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Ethotoin",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused by... | Ethotoin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Et... |
DB00280 | DB00916 | 494 | 112 | [
"DDInter575",
"DDInter1202"
] | Disopyramide | Metronidazole | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
494,
23,
112
]
],
[
[
494,
6,
8374
],
[
8374,
45,
112
]
],
[
[
494,
21,
28757
],
[
28757,
60,
112
]
],
[
[
494,
64,
618
],
[
618,
... | [
[
[
"Disopyramide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Disopyramide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound)
Disopyramide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Metronidazole (Compound)
Disopyramide may lead to a major life threatening interaction when taken with Abarelix and Abarelix ... |
DB00927 | DB11642 | 1,559 | 938 | [
"DDInter712",
"DDInter1480"
] | Famotidine | Pitolisant | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1559,
24,
938
]
],
[
[
1559,
62,
112
],
[
112,
23,
938
]
],
[
[
1559,
63,
600
],
[
600,
24,
938
]
],
[
[
1559,
24,
1228
],
[
1228,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB12332 | DB15822 | 1,619 | 69 | [
"DDInter1626",
"DDInter1504"
] | Rucaparib | Pralsetinib | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1619,
24,
69
]
],
[
[
1619,
24,
283
],
[
283,
24,
69
]
],
[
[
1619,
63,
1213
],
[
1213,
24,
69
]
],
[
[
1619,
64,
985
],
[
985,
... | [
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatini... |
DB00341 | DB00934 | 1,242 | 413 | [
"DDInter343",
"DDInter1124"
] | Cetirizine | Maprotiline | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1242,
24,
413
]
],
[
[
1242,
24,
1302
],
[
1302,
40,
413
]
],
[
[
1242,
6,
10104
],
[
10104,
45,
413
]
],
[
[
1242,
21,
28828
],
[
288... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Cetirizine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Maprotiline (Compound)
Cetirizine (Compound) causes Photosensitivity reaction (Side E... |
DB00059 | DB00851 | 1,560 | 611 | [
"DDInter1404",
"DDInter463"
] | Pegaspargase | Dacarbazine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
1560,
24,
611
]
],
[
[
1560,
24,
1176
],
[
1176,
23,
611
]
],
[
[
1560,
24,
850
],
[
850,
63,
611
]
],
[
[
1560,
24,
912
],
[
912,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moxifloxacin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ve... |
DB08826 | DB08880 | 1,292 | 1,510 | [
"DDInter489",
"DDInter1771"
] | Deferiprone | Teriflunomide | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1292,
25,
1510
]
],
[
[
1292,
24,
1193
],
[
1193,
62,
1510
]
],
[
[
1292,
64,
563
],
[
563,
24,
1510
]
],
[
[
1292,
25,
1580
],
[
1580... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[
"Z... | Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Deferiprone may lead to a major life threatening interaction when taken with Ganciclovir and Ganciclov... |
DB09073 | DB09118 | 951 | 1,580 | [
"DDInter1379",
"DDInter1711"
] | Palbociclib | Stiripentol | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
951,
24,
1580
]
],
[
[
951,
24,
283
],
[
283,
63,
1580
]
],
[
[
951,
24,
98
],
[
98,
24,
1580
]
],
[
[
951,
63,
478
],
[
478,
24... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somat... |
DB00226 | DB09038 | 1,000 | 1,450 | [
"DDInter845",
"DDInter636"
] | Guanadrel | Empagliflozin | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1000,
24,
1450
]
],
[
[
1000,
24,
1061
],
[
1061,
24,
1450
]
],
[
[
1000,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
1000,
24,
1455
],
[
14... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro a... |
DB00992 | DB01015 | 842 | 1,247 | [
"DDInter1182",
"DDInter1724"
] | Methyl aminolevulinate (topical) | Sulfamethoxazole | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Moderate | 1 | [
[
[
842,
24,
1247
]
],
[
[
842,
63,
1029
],
[
1029,
1,
1247
]
],
[
[
842,
24,
698
],
[
698,
1,
1247
]
],
[
[
842,
21,
28787
],
[
28787,
... | [
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole
Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Methyl aminolevu... |
DB00196 | DB12332 | 600 | 1,619 | [
"DDInter743",
"DDInter1626"
] | Fluconazole | Rucaparib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
600,
24,
1619
]
],
[
[
600,
23,
222
],
[
222,
23,
1619
]
],
[
[
600,
25,
1135
],
[
1135,
23,
1619
]
],
[
[
600,
24,
1407
],
[
1407,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Fluconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a m... |
DB00381 | DB08946 | 376 | 512 | [
"DDInter79",
"DDInter962"
] | Amlodipine | Iopanoic acid | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
376,
24,
512
]
],
[
[
376,
7,
7669
],
[
7669,
46,
512
]
],
[
[
376,
40,
1428
],
[
1428,
24,
512
]
],
[
[
376,
1,
336
],
[
336,
2... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Amlodipine",
"{u} (Compound) upregulates {v} (Gene)",
"DDIT4"
],
[
"DDIT4",
"{u} (Gene) is upregulated by {v}... | Amlodipine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Iopanoic acid (Compound)
Amlodipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid
Amlodipine (Compound) resembles Nifedipine (Compou... |
DB00526 | DB01035 | 1,555 | 1,401 | [
"DDInter1355",
"DDInter1524"
] | Oxaliplatin | Procainamide | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A derivative of procaine with less CNS action. | Major | 2 | [
[
[
1555,
25,
1401
]
],
[
[
1555,
6,
10659
],
[
10659,
45,
1401
]
],
[
[
1555,
24,
112
],
[
112,
23,
1401
]
],
[
[
1555,
24,
1683
],
[
168... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procainamide"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A3"
],
[
"SLC22A3",
"{u} (Gene) is bound by {v} (Compound)",
"P... | Oxaliplatin (Compound) binds SLC22A3 (Gene) and SLC22A3 (Gene) is bound by Procainamide (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Procainamide
Oxalip... |
DB11095 | DB11921 | 235 | 1,019 | [
"DDInter505",
"DDInter492"
] | Desirudin | Deflazacort | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
235,
25,
1019
]
],
[
[
235,
63,
1461
],
[
1461,
23,
1019
]
],
[
[
235,
64,
914
],
[
914,
24,
1019
]
],
[
[
235,
63,
116
],
[
116,
... | [
[
[
"Desirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Desirudin may lead to a major life threatening interaction when taken with Diflunisal and Diflunisal may cause a mod... |
DB00346 | DB00916 | 472 | 112 | [
"DDInter44",
"DDInter1202"
] | Alfuzosin | Metronidazole | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
472,
23,
112
]
],
[
[
472,
6,
8374
],
[
8374,
45,
112
]
],
[
[
472,
21,
28692
],
[
28692,
60,
112
]
],
[
[
472,
63,
618
],
[
618,
... | [
[
[
"Alfuzosin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound)
Alfuzosin (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Metronidazole (Compound)
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Abar... |
DB00054 | DB00580 | 1,432 | 311 | [
"DDInter6",
"DDInter1910"
] | Abciximab | Valdecoxib | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
1432,
24,
311
]
],
[
[
1432,
25,
366
],
[
366,
24,
311
]
],
[
[
1432,
25,
500
],
[
500,
63,
311
]
],
[
[
1432,
64,
582
],
[
582,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],
[
"Eptifibati... | Abciximab may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Abciximab may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate in... |
DB01175 | DB11110 | 318 | 603 | [
"DDInter672",
"DDInter1115"
] | Escitalopram | Magnesium citrate | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
318,
24,
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]
],
[
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],
[
57,
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[
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[
1616,
24,
603
]
],
[
[
318,
25,
484
],
[
484,
63,... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Escitalopram may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Escitalopram may lead to a major life threatening interaction when taken with Histrelin and Histrelin may ... |
DB01263 | DB11730 | 859 | 351 | [
"DDInter1494",
"DDInter1588"
] | Posaconazole | Ribociclib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
859,
25,
351
]
],
[
[
859,
24,
466
],
[
466,
62,
351
]
],
[
[
859,
62,
112
],
[
112,
23,
351
]
],
[
[
859,
25,
283
],
[
283,
62,... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daro... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and... |
DB00009 | DB00814 | 1,271 | 1,171 | [
"DDInter56",
"DDInter1143"
] | Alteplase | Meloxicam | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
1271,
24,
1171
]
],
[
[
1271,
24,
1027
],
[
1027,
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1171
]
],
[
[
1271,
25,
936
],
[
936,
63,
1171
]
],
[
[
1271,
24,
477
],
[
477,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
],
[
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Alteplase may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may cause a moderate interaction that could exacerbate diseases w... |
DB00033 | DB00446 | 342 | 597 | [
"DDInter949",
"DDInter351"
] | Interferon gamma-1b | Chloramphenicol | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
342,
24,
597
]
],
[
[
342,
25,
1101
],
[
1101,
23,
597
]
],
[
[
342,
24,
599
],
[
599,
24,
597
]
],
[
[
342,
24,
810
],
[
810,
6... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Interferon gamma-1b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
... | Interferon gamma-1b may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and... |
DB09036 | DB14711 | 812 | 779 | [
"DDInter1668",
"DDInter1680"
] | Siltuximab | Smallpox (Vaccinia) Vaccine, Live | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
812,
25,
779
]
],
[
[
812,
64,
1064
],
[
1064,
25,
779
]
],
[
[
812,
63,
147
],
[
147,
25,
779
]
],
[
[
812,
25,
1259
],
[
1259,
... | [
[
[
"Siltuximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Siltuximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Siltuximab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine ... |
DB00023 | DB08896 | 305 | 292 | [
"DDInter127",
"DDInter1576"
] | Asparaginase Escherichia coli | Regorafenib | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
305,
24,
292
]
],
[
[
305,
24,
79
],
[
79,
1,
292
]
],
[
[
305,
24,
549
],
[
549,
23,
292
]
],
[
[
305,
24,
901
],
[
901,
24,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin ... |
DB00701 | DB09043 | 1,091 | 135 | [
"DDInter90",
"DDInter36"
] | Amprenavir | Albiglutide | Amprenavir is a protease inhibitor used to treat HIV infection. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1091,
24,
135
]
],
[
[
1091,
63,
126
],
[
126,
23,
135
]
],
[
[
1091,
64,
467
],
[
467,
23,
135
]
],
[
[
1091,
63,
870
],
[
870,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Amprenavir may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin may cause a m... |
DB01075 | DB09293 | 1,376 | 116 | [
"DDInter569",
"DDInter954"
] | Diphenhydramine | Iodide I-131 | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1376,
24,
116
]
],
[
[
1376,
63,
701
],
[
701,
24,
116
]
],
[
[
1376,
24,
516
],
[
516,
24,
116
]
],
[
[
1376,
74,
100
],
[
100,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Levocetir... |
DB00390 | DB00757 | 1,252 | 1,166 | [
"DDInter554",
"DDInter581"
] | Digoxin | Dolasetron | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1252,
25,
1166
]
],
[
[
1252,
23,
19
],
[
19,
40,
1166
]
],
[
[
1252,
23,
85
],
[
85,
1,
1166
]
],
[
[
1252,
6,
8374
],
[
8374,
... | [
[
[
"Digoxin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Digoxin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamine",
... | Digoxin may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Digoxin may cause a minor interaction that can limit clinical effects when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
Digoxin (Com... |
DB00014 | DB09268 | 521 | 1,662 | [
"DDInter839",
"DDInter1464"
] | Goserelin | Picosulfuric acid | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
521,
24,
1662
]
],
[
[
521,
24,
1164
],
[
1164,
24,
1662
]
],
[
[
521,
24,
484
],
[
484,
63,
1662
]
],
[
[
521,
25,
1618
],
[
1618,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
],
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib ... |
DB01410 | DB15699 | 423 | 652 | [
"DDInter375",
"DDInter232"
] | Ciclesonide | Brexucabtagene autoleucel | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
423,
25,
652
]
],
[
[
423,
24,
4
],
[
4,
24,
652
]
],
[
[
423,
1,
617
],
[
617,
25,
652
]
],
[
[
423,
40,
218
],
[
218,
25,
... | [
[
[
"Ciclesonide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Ciclesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate... | Ciclesonide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Ciclesonide (Compound) resembles Budesonide (Compound) and Budeson... |
DB00250 | DB00553 | 10 | 92 | [
"DDInter475",
"DDInter1177"
] | Dapsone | Methoxsalen | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Moderate | 1 | [
[
[
10,
24,
92
]
],
[
[
10,
6,
8374
],
[
8374,
45,
92
]
],
[
[
10,
21,
29547
],
[
29547,
60,
92
]
],
[
[
10,
1,
1247
],
[
1247,
63,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxsalen"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Dapsone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methoxsalen (Compound)
Dapsone (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Methoxsalen (Compound)
Dapsone (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate i... |
DB00284 | DB08912 | 1,647 | 1,040 | [
"DDInter11",
"DDInter462"
] | Acarbose | Dabrafenib | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1647,
24,
1040
]
],
[
[
1647,
7,
10643
],
[
10643,
46,
1040
]
],
[
[
1647,
6,
8814
],
[
8814,
46,
1040
]
],
[
[
1647,
18,
4893
],
[
48... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Acarbose",
"{u} (Compound) upregulates {v} (Gene)",
"EAPP"
],
[
"EAPP",
"{u} (Gene) is upregulated by {v} (Compoun... | Acarbose (Compound) upregulates EAPP (Gene) and EAPP (Gene) is upregulated by Dabrafenib (Compound)
Acarbose (Compound) binds GAA (Gene) and GAA (Gene) is upregulated by Dabrafenib (Compound)
Acarbose (Compound) downregulates S100A13 (Gene) and S100A13 (Gene) is upregulated by Dabrafenib (Compound)
Acarbose (Compound) ... |
DB00675 | DB00843 | 888 | 479 | [
"DDInter1744",
"DDInter583"
] | Tamoxifen | Donepezil | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
888,
24,
479
]
],
[
[
888,
24,
843
],
[
843,
1,
479
]
],
[
[
888,
6,
12523
],
[
12523,
45,
479
]
],
[
[
888,
7,
3163
],
[
3163,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Tamoxifen (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Tamoxifen (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gen... |
DB01319 | DB11986 | 34 | 484 | [
"DDInter777",
"DDInter648"
] | Fosamprenavir | Entrectinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
34,
25,
484
]
],
[
[
34,
23,
466
],
[
466,
62,
484
]
],
[
[
34,
25,
1135
],
[
1135,
23,
484
]
],
[
[
34,
63,
510
],
[
510,
24,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Fosamprenavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
"Dar... | Fosamprenavir may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Fosamprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may c... |
DB00341 | DB00836 | 1,242 | 543 | [
"DDInter343",
"DDInter1088"
] | Cetirizine | Loperamide | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
1242,
24,
543
]
],
[
[
1242,
24,
704
],
[
704,
40,
543
]
],
[
[
1242,
40,
11366
],
[
11366,
40,
543
]
],
[
[
1242,
24,
649
],
[
649,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Loperamide (Compound)
Cetirizine (Compound) resembles Anileridine (Compound) and Anileridine (Compound) resembles Loperamide (Compound)
Cetirizine may cause a moderate interaction that c... |
DB00445 | DB00697 | 322 | 876 | [
"DDInter655",
"DDInter1821"
] | Epirubicin | Tizanidine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
322,
24,
876
]
],
[
[
322,
18,
6718
],
[
6718,
57,
876
]
],
[
[
322,
7,
4893
],
[
4893,
57,
876
]
],
[
[
322,
21,
28882
],
[
28882,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Epirubicin",
"{u} (Compound) downregulates {v} (Gene)",
"USP22"
],
[
"USP22",
"{u} (Gene) is downregulated by {v... | Epirubicin (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Tizanidine (Compound)
Epirubicin (Compound) upregulates S100A13 (Gene) and S100A13 (Gene) is downregulated by Tizanidine (Compound)
Epirubicin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (... |
DB00215 | DB14568 | 1,230 | 982 | [
"DDInter388",
"DDInter1000"
] | Citalopram | Ivosidenib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1230,
25,
982
]
],
[
[
1230,
23,
112
],
[
112,
23,
982
]
],
[
[
1230,
62,
168
],
[
168,
23,
982
]
],
[
[
1230,
24,
543
],
[
543,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Citalopram may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortez... |
DB01215 | DB06282 | 1,418 | 516 | [
"DDInter677",
"DDInter1053"
] | Estazolam | Levocetirizine | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1418,
24,
516
]
],
[
[
1418,
62,
1031
],
[
1031,
23,
516
]
],
[
[
1418,
24,
1074
],
[
1074,
63,
516
]
],
[
[
1418,
63,
701
],
[
701,
... | [
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Estazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
],
[
... | Estazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Io... |
DB00619 | DB13179 | 1,419 | 68 | [
"DDInter909",
"DDInter1882"
] | Imatinib | Troleandomycin | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
1419,
24,
68
]
],
[
[
1419,
63,
1601
],
[
1601,
23,
68
]
],
[
[
1419,
62,
1101
],
[
1101,
23,
68
]
],
[
[
1419,
23,
222
],
[
222,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Imatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene... |
DB00619 | DB11986 | 1,419 | 484 | [
"DDInter909",
"DDInter648"
] | Imatinib | Entrectinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1419,
25,
484
]
],
[
[
1419,
23,
271
],
[
271,
23,
484
]
],
[
[
1419,
24,
466
],
[
466,
62,
484
]
],
[
[
1419,
25,
1135
],
[
1135,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamid... |
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