drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB09134 | DB12615 | 1,552 | 1,381 | [
"DDInter966",
"DDInter1482"
] | Ioversol | Plazomicin | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Major | 2 | [
[
[
1552,
25,
1381
]
],
[
[
1552,
64,
416
],
[
416,
24,
1381
]
],
[
[
1552,
64,
1441
],
[
1441,
25,
1381
]
],
[
[
1552,
64,
416
],
[
416,
... | [
[
[
"Ioversol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plazomicin"
]
],
[
[
"Ioversol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Kanamycin"
],
[
"Kanamycin",
"{u} may cau... | Ioversol may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Ioversol may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin may lead to a major life threat... |
DB06691 | DB11859 | 849 | 418 | [
"DDInter1155",
"DDInter230"
] | Mepyramine | Brexanolone | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like various other types of depr... | Moderate | 1 | [
[
[
849,
24,
418
]
],
[
[
849,
63,
820
],
[
820,
24,
418
]
],
[
[
849,
74,
100
],
[
100,
24,
418
]
],
[
[
849,
24,
407
],
[
407,
24,... | [
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexanolone"
]
],
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Brexanolone
Mepyramine (Compound) resembles Brompheniramine (Compound) and Mepyramine may cause a moderate interaction th... |
DB00736 | DB08931 | 660 | 947 | [
"DDInter676",
"DDInter1600"
] | Esomeprazole | Riociguat | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Moderate | 1 | [
[
[
660,
24,
947
]
],
[
[
660,
1,
379
],
[
379,
24,
947
]
],
[
[
660,
23,
609
],
[
609,
24,
947
]
],
[
[
660,
24,
913
],
[
913,
63,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riociguat"
]
],
[
[
"Esomeprazole",
"{u} (Compound) resembles {v} (Compound)",
"Rabeprazole"
],
[
"Rabeprazole",
"{u} may cause a mo... | Esomeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may cause a moderate interaction... |
DB00196 | DB00532 | 600 | 208 | [
"DDInter743",
"DDInter1152"
] | Fluconazole | Mephenytoin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Major | 2 | [
[
[
600,
25,
208
]
],
[
[
600,
24,
608
],
[
608,
23,
208
]
],
[
[
600,
24,
660
],
[
660,
62,
208
]
],
[
[
600,
24,
1613
],
[
1613,
6... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mephenytoin"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocain... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Mephenytoin
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esome... |
DB00512 | DB00783 | 91 | 1,438 | [
"DDInter1916",
"DDInter679"
] | Vancomycin | Estradiol | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Moderate | 1 | [
[
[
91,
24,
1438
]
],
[
[
91,
24,
890
],
[
890,
40,
1438
]
],
[
[
91,
21,
28698
],
[
28698,
60,
1438
]
],
[
[
91,
25,
629
],
[
629,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Estradiol (Compound)
Vancomycin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Estradiol (Compound)
Vancomycin may lead to a major life threatening in... |
DB00208 | DB01377 | 1,018 | 1,283 | [
"DDInter1804",
"DDInter1119"
] | Ticlopidine | Magnesium oxide | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
1018,
23,
1283
]
],
[
[
1018,
25,
684
],
[
684,
23,
1283
]
],
[
[
1018,
24,
831
],
[
831,
23,
1283
]
],
[
[
1018,
23,
1252
],
[
1252,
... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thi... | Ticlopidine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethac... |
DB00581 | DB05812 | 355 | 1,374 | [
"DDInter1018",
"DDInter8"
] | Lactulose | Abiraterone | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
355,
24,
1374
]
],
[
[
355,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
355,
63,
1028
],
[
1028,
24,
1374
]
],
[
[
355,
24,
1133
],
[
1133... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Lactulose",
"{u} (Compound) causes {v} (Side Effect)",
"Hypokalaemia"
],
[
"Hypokalaemia",
"{u} (Side Effect) is... | Lactulose (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Torasemide and Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Ab... |
DB00938 | DB01238 | 455 | 673 | [
"DDInter1635",
"DDInter118"
] | Salmeterol | Aripiprazole | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
455,
24,
673
]
],
[
[
455,
25,
851
],
[
851,
1,
673
]
],
[
[
455,
63,
827
],
[
827,
40,
673
]
],
[
[
455,
63,
1630
],
[
1630,
1,... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Salmeterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
],
[
"Nefazodo... | Salmeterol may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Salmeterol ma... |
DB00477 | DB01124 | 216 | 1,411 | [
"DDInter363",
"DDInter1828"
] | Chlorpromazine | Tolbutamide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
216,
24,
1411
]
],
[
[
216,
24,
959
],
[
959,
40,
1411
]
],
[
[
216,
63,
245
],
[
245,
40,
1411
]
],
[
[
216,
21,
29222
],
[
29222,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (... |
DB00365 | DB06335 | 839 | 761 | [
"DDInter842",
"DDInter1646"
] | Grepafloxacin | Saxagliptin | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
839,
24,
761
]
],
[
[
839,
25,
1491
],
[
1491,
63,
761
]
],
[
[
839,
25,
1573
],
[
1573,
24,
761
]
],
[
[
839,
64,
600
],
[
600,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
],
[
"Mi... | Grepafloxacin may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Grepafloxacin may lead to a major life threatening interaction when taken with Prednisone and Prednisone may cause a mode... |
DB00390 | DB00451 | 1,252 | 542 | [
"DDInter554",
"DDInter1064"
] | Digoxin | Levothyroxine | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
1252,
24,
542
]
],
[
[
1252,
63,
1152
],
[
1152,
1,
542
]
],
[
[
1252,
6,
15333
],
[
15333,
45,
542
]
],
[
[
1252,
7,
7273
],
[
7273,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (Compound)
Digoxin (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Levothyroxine (Compound)
Digoxin (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (G... |
DB01023 | DB09098 | 409 | 98 | [
"DDInter716",
"DDInter1700"
] | Felodipine | Somatrem | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
409,
24,
98
]
],
[
[
409,
1,
336
],
[
336,
24,
98
]
],
[
[
409,
24,
159
],
[
159,
63,
98
]
],
[
[
409,
63,
1573
],
[
1573,
24,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Felodipine",
"{u} (Compound) resembles {v} (Compound)",
"Nifedipine"
],
[
"Nifedipine",
"{u} may cause a moderate ... | Felodipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that c... |
DB01244 | DB11760 | 762 | 119 | [
"DDInter192",
"DDInter1742"
] | Bepridil | Talazoparib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
762,
24,
119
]
],
[
[
762,
25,
985
],
[
985,
24,
119
]
],
[
[
762,
24,
1478
],
[
1478,
24,
119
]
],
[
[
762,
25,
971
],
[
971,
6... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
],
[
"Osimertinib"... | Bepridil may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a m... |
DB01211 | DB06288 | 609 | 607 | [
"DDInter393",
"DDInter77"
] | Clarithromycin | Amisulpride | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
609,
25,
607
]
],
[
[
609,
21,
29232
],
[
29232,
60,
607
]
],
[
[
609,
62,
112
],
[
112,
23,
607
]
],
[
[
609,
63,
1559
],
[
1559,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Clarithromycin",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is caused by ... | Clarithromycin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00804 | DB08815 | 1,507 | 154 | [
"DDInter543",
"DDInter1104"
] | Dicyclomine | Lurasidone | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
1507,
24,
154
]
],
[
[
1507,
21,
29118
],
[
29118,
60,
154
]
],
[
[
1507,
24,
100
],
[
100,
24,
154
]
],
[
[
1507,
63,
1233
],
[
1233,... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Dicyclomine",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) i... | Dicyclomine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Lurasidone (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when ta... |
DB06699 | DB12825 | 774 | 1,375 | [
"DDInter493",
"DDInter1032"
] | Degarelix | Lefamulin | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
774,
25,
1375
]
],
[
[
774,
62,
112
],
[
112,
23,
1375
]
],
[
[
774,
24,
659
],
[
659,
24,
1375
]
],
[
[
774,
63,
455
],
[
455,
... | [
[
[
"Degarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilante... |
DB01229 | DB01265 | 973 | 1,477 | [
"DDInter1378",
"DDInter1757"
] | Paclitaxel (protein-bound) | Telbivudine | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
973,
24,
1477
]
],
[
[
973,
63,
139
],
[
139,
1,
1477
]
],
[
[
973,
21,
28745
],
[
28745,
60,
1477
]
],
[
[
973,
63,
112
],
[
112,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Telbivudine (Compound)
Paclitaxel (Compound) causes Neuropathy peripheral (Side... |
DB09118 | DB09143 | 1,580 | 313 | [
"DDInter1711",
"DDInter1701"
] | Stiripentol | Sonidegib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
1580,
25,
313
]
],
[
[
1580,
63,
379
],
[
379,
23,
313
]
],
[
[
1580,
63,
478
],
[
478,
24,
313
]
],
[
[
1580,
25,
484
],
[
484,
... | [
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
"Rabepraz... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB00604 | DB13913 | 1,425 | 1,536 | [
"DDInter385",
"DDInter175"
] | Cisapride | Belladonna | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
1425,
24,
1536
]
],
[
[
1425,
24,
412
],
[
412,
24,
1536
]
],
[
[
1425,
25,
1264
],
[
1264,
24,
1536
]
],
[
[
1425,
63,
19
],
[
19,
... | [
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
],
[
... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline and Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Cisapride may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a mode... |
DB00618 | DB01309 | 1,572 | 1,254 | [
"DDInter498",
"DDInter933"
] | Demeclocycline | Insulin glulisine | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1572,
24,
1254
]
],
[
[
1572,
1,
1669
],
[
1669,
24,
1254
]
],
[
[
1572,
40,
964
],
[
964,
24,
1254
]
],
[
[
1572,
24,
266
],
[
266,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Demeclocycline",
"{u} (Compound) resembles {v} (Compound)",
"Minocycline"
],
[
"Minocycline",
"{u} ma... | Demeclocycline (Compound) resembles Minocycline (Compound) and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Demeclocycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate interaction that could exacerbate diseases when tak... |
DB00059 | DB00252 | 1,560 | 362 | [
"DDInter1404",
"DDInter1460"
] | Pegaspargase | Phenytoin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Moderate | 1 | [
[
[
1560,
24,
362
]
],
[
[
1560,
24,
126
],
[
126,
63,
362
]
],
[
[
1560,
24,
1236
],
[
1236,
40,
362
]
],
[
[
1560,
25,
1101
],
[
1101,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carb... |
DB05578 | DB06605 | 330 | 1,409 | [
"DDInter1566",
"DDInter108"
] | Ramucirumab | Apixaban | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
330,
25,
1409
]
],
[
[
330,
63,
109
],
[
109,
24,
1409
]
],
[
[
330,
24,
41
],
[
41,
63,
1409
]
],
[
[
330,
25,
972
],
[
972,
63... | [
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Ramucirumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
[
"Duloxetine... | Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and L... |
DB00465 | DB08901 | 886 | 1,468 | [
"DDInter1010",
"DDInter1492"
] | Ketorolac | Ponatinib | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
886,
25,
1468
]
],
[
[
886,
7,
20038
],
[
20038,
46,
1468
]
],
[
[
886,
18,
20113
],
[
20113,
57,
1468
]
],
[
[
886,
21,
29271
],
[
29... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Ketorolac",
"{u} (Compound) upregulates {v} (Gene)",
"FAIM"
],
[
"FAIM",
"{u} (Gene) is upregulated by {v} (Compound)",
"Po... | Ketorolac (Compound) upregulates FAIM (Gene) and FAIM (Gene) is upregulated by Ponatinib (Compound)
Ketorolac (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Ponatinib (Compound)
Ketorolac (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Ponatinib (Compound)
Keto... |
DB00741 | DB01149 | 167 | 851 | [
"DDInter885",
"DDInter1274"
] | Hydrocortisone | Nefazodone | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
167,
24,
851
]
],
[
[
167,
24,
1178
],
[
1178,
1,
851
]
],
[
[
167,
6,
8374
],
[
8374,
45,
851
]
],
[
[
167,
7,
4759
],
[
4759,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Nefazodone (Compound)
Hydrocortisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Hydrocortisone (Compound) upregulates SERPINA3 (... |
DB00741 | DB06819 | 167 | 754 | [
"DDInter885",
"DDInter1452"
] | Hydrocortisone | Phenylbutyric acid | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and ur... | Moderate | 1 | [
[
[
167,
24,
754
]
],
[
[
167,
1,
891
],
[
891,
24,
754
]
],
[
[
167,
63,
1236
],
[
1236,
24,
754
]
],
[
[
167,
40,
870
],
[
870,
24... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutyric acid"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Prednisolone"
],
[
"Prednisolone",
"{u}... | Hydrocortisone (Compound) resembles Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine may cause a moder... |
DB08895 | DB11652 | 976 | 1,155 | [
"DDInter1825",
"DDInter1891"
] | Tofacitinib | Tucatinib | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Major | 2 | [
[
[
976,
25,
1155
]
],
[
[
976,
64,
1101
],
[
1101,
23,
1155
]
],
[
[
976,
64,
609
],
[
609,
24,
1155
]
],
[
[
976,
24,
1320
],
[
1320,
... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tucatinib"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
"{u} ... | Tofacitinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Tofacitinib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a modera... |
DB00512 | DB00631 | 91 | 372 | [
"DDInter1916",
"DDInter405"
] | Vancomycin | Clofarabine | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
91,
24,
372
]
],
[
[
91,
21,
28882
],
[
28882,
60,
372
]
],
[
[
91,
24,
59
],
[
59,
63,
372
]
],
[
[
91,
24,
1441
],
[
1441,
24,... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Vancomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased... | Vancomycin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Clofarabine (Compound)
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Etodolac and Etodolac may cause a moderate interaction that could exacerbate d... |
DB00242 | DB11988 | 1,064 | 270 | [
"DDInter392",
"DDInter1321"
] | Cladribine | Ocrelizumab | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Major | 2 | [
[
[
1064,
25,
270
]
],
[
[
1064,
63,
1461
],
[
1461,
23,
270
]
],
[
[
1064,
25,
1060
],
[
1060,
63,
270
]
],
[
[
1064,
25,
134
],
[
134,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Cladribine may lead to a major life threatening interaction when taken with Enfortumab vedotin and Enfortumab vedot... |
DB00344 | DB00414 | 1,302 | 590 | [
"DDInter1543",
"DDInter16"
] | Protriptyline | Acetohexamide | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
1302,
24,
590
]
],
[
[
1302,
25,
874
],
[
874,
63,
590
]
],
[
[
1302,
24,
1424
],
[
1424,
63,
590
]
],
[
[
1302,
63,
521
],
[
521,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"... | Protriptyline may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may c... |
DB01390 | DB01396 | 1,117 | 1,482 | [
"DDInter1683",
"DDInter553"
] | Sodium bicarbonate | Digitoxin | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Minor | 0 | [
[
[
1117,
23,
1482
]
],
[
[
1117,
62,
1252
],
[
1252,
1,
1482
]
],
[
[
1117,
62,
752
],
[
752,
23,
1482
]
],
[
[
1117,
63,
1445
],
[
1445,... | [
[
[
"Sodium bicarbonate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Digitoxin"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Digoxin"
],
... | Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can... |
DB00401 | DB06168 | 84 | 1,531 | [
"DDInter1298",
"DDInter281"
] | Nisoldipine | Canakinumab | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
84,
24,
1531
]
],
[
[
84,
24,
1476
],
[
1476,
63,
1531
]
],
[
[
84,
24,
1213
],
[
1213,
24,
1531
]
],
[
[
84,
62,
1031
],
[
1031,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasa... |
DB11799 | DB12500 | 627 | 283 | [
"DDInter205",
"DDInter714"
] | Bictegravir | Fedratinib | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
627,
24,
283
]
],
[
[
627,
24,
466
],
[
466,
62,
283
]
],
[
[
627,
63,
351
],
[
351,
23,
283
]
],
[
[
627,
63,
1419
],
[
1419,
2... | [
[
[
"Bictegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Bictegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ri... |
DB08912 | DB15328 | 1,040 | 829 | [
"DDInter462",
"DDInter1896"
] | Dabrafenib | Ubrogepant | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
1040,
24,
829
]
],
[
[
1040,
25,
1476
],
[
1476,
24,
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]
],
[
[
1040,
63,
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],
[
1468,
24,
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]
],
[
[
1040,
24,
971
],
[
971,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib... | Dabrafenib may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a ... |
DB00308 | DB01211 | 347 | 609 | [
"DDInter901",
"DDInter393"
] | Ibutilide | Clarithromycin | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
347,
25,
609
]
],
[
[
347,
21,
28789
],
[
28789,
60,
609
]
],
[
[
347,
64,
600
],
[
600,
23,
609
]
],
[
[
347,
23,
112
],
[
112,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
"{u} (Side Effe... | Ibutilide (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Clarithromycin (Compound)
Ibutilide may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00163 | DB06772 | 1,461 | 310 | [
"DDInter1943",
"DDInter259"
] | Vitamin E | Cabazitaxel | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
1461,
24,
310
]
],
[
[
1461,
24,
973
],
[
973,
24,
310
]
],
[
[
1461,
24,
350
],
[
350,
63,
310
]
],
[
[
1461,
23,
1531
],
[
1531,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfil... |
DB00569 | DB11793 | 553 | 738 | [
"DDInter775",
"DDInter1297"
] | Fondaparinux | Niraparib | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
553,
24,
738
]
],
[
[
553,
25,
1213
],
[
1213,
24,
738
]
],
[
[
553,
64,
1578
],
[
1578,
24,
738
]
],
[
[
553,
75,
202
],
[
202,
... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatini... | Fondaparinux may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Fondaparinux may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate inter... |
DB00708 | DB00771 | 1,454 | 262 | [
"DDInter1718",
"DDInter397"
] | Sufentanil | Clidinium | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
1454,
24,
262
]
],
[
[
1454,
24,
1511
],
[
1511,
63,
262
]
],
[
[
1454,
1,
704
],
[
704,
63,
262
]
],
[
[
1454,
63,
19
],
[
19,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Sufentanil (Compound) resembles Fentanyl (Compound) and Fentanyl may cause a moderate interaction that could ex... |
DB01097 | DB04865 | 1,377 | 4 | [
"DDInter1033",
"DDInter1335"
] | Leflunomide | Omacetaxine mepesuccinate | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
1377,
25,
4
]
],
[
[
1377,
18,
8386
],
[
8386,
57,
4
]
],
[
[
1377,
64,
1394
],
[
1394,
24,
4
]
],
[
[
1377,
25,
994
],
[
994,
6... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Leflunomide",
"{u} (Compound) downregulates {v} (Gene)",
"MTHFD2"
],
[
"MTHFD2",
"{u} (Gene) is downregulated b... | Leflunomide (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Rituximab and Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine m... |
DB01100 | DB08816 | 1,568 | 578 | [
"DDInter1470",
"DDInter1802"
] | Pimozide | Ticagrelor | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1568,
24,
578
]
],
[
[
1568,
6,
4973
],
[
4973,
45,
578
]
],
[
[
1568,
21,
28646
],
[
28646,
60,
578
]
],
[
[
1568,
25,
1011
],
[
1011... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Pimozide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Pimozide (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Pimozide may lead to a major l... |
DB00731 | DB09098 | 1,144 | 98 | [
"DDInter1269",
"DDInter1700"
] | Nateglinide | Somatrem | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1144,
24,
98
]
],
[
[
1144,
63,
168
],
[
168,
23,
98
]
],
[
[
1144,
24,
671
],
[
671,
24,
98
]
],
[
[
1144,
24,
159
],
[
159,
63... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvast... |
DB05773 | DB08896 | 1,047 | 292 | [
"DDInter1848",
"DDInter1576"
] | Trastuzumab emtansine | Regorafenib | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
1047,
25,
292
]
],
[
[
1047,
24,
643
],
[
643,
24,
292
]
],
[
[
1047,
24,
327
],
[
327,
63,
292
]
],
[
[
1047,
63,
1560
],
[
1560,
... | [
[
[
"Trastuzumab emtansine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when t... |
DB06704 | DB14443 | 247 | 987 | [
"DDInter952",
"DDInter1931"
] | Iobenguane (I-131) | Vibrio cholerae CVD 103-HgR strain live antigen | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
247,
24,
987
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
24,
987
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
24,
... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate disea... |
DB00691 | DB01261 | 1,058 | 170 | [
"DDInter1237",
"DDInter1679"
] | Moexipril | Sitagliptin | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1058,
24,
170
]
],
[
[
1058,
24,
708
],
[
708,
63,
170
]
],
[
[
1058,
40,
1638
],
[
1638,
24,
170
]
],
[
[
1058,
63,
1179
],
[
1179,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin
Moexipril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a moderate interaction t... |
DB00563 | DB08904 | 663 | 375 | [
"DDInter1174",
"DDInter342"
] | Methotrexate | Certolizumab pegol | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
663,
25,
375
]
],
[
[
663,
63,
1461
],
[
1461,
23,
375
]
],
[
[
663,
24,
231
],
[
231,
24,
375
]
],
[
[
663,
24,
200
],
[
200,
6... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and... |
DB00372 | DB01136 | 999 | 772 | [
"DDInter1793",
"DDInter305"
] | Thiethylperazine | Carvedilol | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
999,
24,
772
]
],
[
[
999,
23,
1283
],
[
1283,
62,
772
]
],
[
[
999,
62,
417
],
[
417,
23,
772
]
],
[
[
999,
63,
475
],
[
475,
2... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Thiethylperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
... | Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide and Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Carvedilol
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Sucra... |
DB00295 | DB00381 | 475 | 376 | [
"DDInter1244",
"DDInter79"
] | Morphine | Amlodipine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Moderate | 1 | [
[
[
475,
24,
376
]
],
[
[
475,
63,
1428
],
[
1428,
1,
376
]
],
[
[
475,
24,
409
],
[
409,
1,
376
]
],
[
[
475,
24,
1081
],
[
1081,
4... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Amlodipine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Amlodipine (Compound)
Morp... |
DB00762 | DB14711 | 613 | 779 | [
"DDInter973",
"DDInter1680"
] | Irinotecan | Smallpox (Vaccinia) Vaccine, Live | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
613,
25,
779
]
],
[
[
613,
64,
1064
],
[
1064,
25,
779
]
],
[
[
613,
24,
478
],
[
478,
25,
779
]
],
[
[
613,
25,
1377
],
[
1377,
... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Irinotecan may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may ... |
DB00996 | DB06691 | 1,198 | 849 | [
"DDInter791",
"DDInter1155"
] | Gabapentin | Mepyramine | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1198,
24,
849
]
],
[
[
1198,
63,
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],
[
1594,
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[
[
1198,
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],
[
272,
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]
],
[
[
1198,
24,
407
],
[
407,
... | [
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and ... |
DB00879 | DB08870 | 1,279 | 850 | [
"DDInter637",
"DDInter228"
] | Emtricitabine | Brentuximab vedotin | Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse t... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1279,
24,
850
]
],
[
[
1279,
63,
267
],
[
267,
24,
850
]
],
[
[
1279,
24,
1142
],
[
1142,
24,
850
]
],
[
[
1279,
24,
1618
],
[
1618,
... | [
[
[
"Emtricitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Emtricitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Emtricitabine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Emtricitabine may cause a moderate interaction that could exacerbate diseases when taken with Orlist... |
DB00059 | DB09038 | 1,560 | 1,450 | [
"DDInter1404",
"DDInter636"
] | Pegaspargase | Empagliflozin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1560,
24,
1450
]
],
[
[
1560,
24,
1551
],
[
1551,
24,
1450
]
],
[
[
1560,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
1560,
24,
517
],
[
517... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyldopa"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro... |
DB00390 | DB11348 | 1,252 | 1,065 | [
"DDInter554",
"DDInter279"
] | Digoxin | Calcium Phosphate | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
1252,
24,
1065
]
],
[
[
1252,
24,
1620
],
[
1620,
24,
1065
]
],
[
[
1252,
63,
964
],
[
964,
24,
1065
]
],
[
[
1252,
1,
1482
],
[
1482,... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
],
[... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and ... |
DB00218 | DB00712 | 1,176 | 1,274 | [
"DDInter1247",
"DDInter763"
] | Moxifloxacin | Flurbiprofen | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1176,
24,
1274
]
],
[
[
1176,
21,
28769
],
[
28769,
60,
1274
]
],
[
[
1176,
24,
1559
],
[
1559,
62,
1274
]
],
[
[
1176,
24,
1613
],
[
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u} (... | Moxifloxacin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a minor interaction that can limit clinical effects when ... |
DB00361 | DB08899 | 134 | 129 | [
"DDInter1939",
"DDInter649"
] | Vinorelbine | Enzalutamide | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
134,
24,
129
]
],
[
[
134,
6,
8374
],
[
8374,
45,
129
]
],
[
[
134,
21,
28703
],
[
28703,
60,
129
]
],
[
[
134,
24,
110
],
[
110,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Vinorelbine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab ve... |
DB00675 | DB14568 | 888 | 982 | [
"DDInter1744",
"DDInter1000"
] | Tamoxifen | Ivosidenib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
888,
25,
982
]
],
[
[
888,
25,
271
],
[
271,
23,
982
]
],
[
[
888,
23,
112
],
[
112,
23,
982
]
],
[
[
888,
63,
1101
],
[
1101,
2... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
"{u} may... | Tamoxifen may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause ... |
DB06228 | DB15762 | 792 | 725 | [
"DDInter1609",
"DDInter1644"
] | Rivaroxaban | Satralizumab | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
792,
24,
725
]
],
[
[
792,
24,
384
],
[
384,
24,
725
]
],
[
[
792,
63,
597
],
[
597,
24,
725
]
],
[
[
792,
64,
4
],
[
4,
24,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol a... |
DB00851 | DB14730 | 611 | 1,412 | [
"DDInter463",
"DDInter264"
] | Dacarbazine | Calaspargase pegol | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
611,
24,
1412
]
],
[
[
611,
63,
322
],
[
322,
24,
1412
]
],
[
[
611,
24,
850
],
[
850,
24,
1412
]
],
[
[
611,
64,
1648
],
[
1648,
... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab... |
DB00978 | DB09045 | 739 | 52 | [
"DDInter1084",
"DDInter607"
] | Lomefloxacin | Dulaglutide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
739,
24,
52
]
],
[
[
739,
24,
170
],
[
170,
23,
52
]
],
[
[
739,
24,
609
],
[
609,
24,
52
]
],
[
[
739,
1,
1467
],
[
1467,
24,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin a... |
DB00816 | DB00831 | 1,674 | 1,178 | [
"DDInter1346",
"DDInter1866"
] | Orciprenaline | Trifluoperazine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1674,
24,
1178
]
],
[
[
1674,
64,
695
],
[
695,
40,
1178
]
],
[
[
1674,
24,
9
],
[
9,
1,
1178
]
],
[
[
1674,
63,
216
],
[
216,
4... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"... | Orciprenaline may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Trifluoperazin... |
DB00222 | DB01097 | 245 | 1,377 | [
"DDInter825",
"DDInter1033"
] | Glimepiride | Leflunomide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Moderate | 1 | [
[
[
245,
24,
1377
]
],
[
[
245,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
245,
21,
28864
],
[
28864,
60,
1377
]
],
[
[
245,
24,
126
],
[
126,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leflunomide"
]
],
[
[
"Glimepiride",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Glimepiride (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Leflunomide (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken... |
DB00620 | DB01067 | 175 | 959 | [
"DDInter1855",
"DDInter826"
] | Triamcinolone | Glipizide | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
175,
24,
959
]
],
[
[
175,
63,
245
],
[
245,
40,
959
]
],
[
[
175,
24,
1411
],
[
1411,
1,
959
]
],
[
[
175,
6,
8374
],
[
8374,
4... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Co... |
DB00436 | DB00448 | 323 | 1,215 | [
"DDInter179",
"DDInter1022"
] | Bendroflumethiazide | Lansoprazole | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Moderate | 1 | [
[
[
323,
24,
1215
]
],
[
[
323,
24,
379
],
[
379,
1,
1215
]
],
[
[
323,
63,
837
],
[
837,
1,
1215
]
],
[
[
323,
21,
28954
],
[
28954,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabepra... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Lansoprazole (Compound)
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole (Compound) resemb... |
DB00704 | DB00851 | 267 | 611 | [
"DDInter1263",
"DDInter463"
] | Naltrexone | Dacarbazine | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
267,
24,
611
]
],
[
[
267,
7,
20092
],
[
20092,
46,
611
]
],
[
[
267,
63,
1176
],
[
1176,
23,
611
]
],
[
[
267,
24,
850
],
[
850,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Naltrexone",
"{u} (Compound) upregulates {v} (Gene)",
"TCTA"
],
[
"TCTA",
"{u} (Gene) is upregulated by {v} (Co... | Naltrexone (Compound) upregulates TCTA (Gene) and TCTA (Gene) is upregulated by Dacarbazine (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine
Naltre... |
DB00252 | DB00501 | 362 | 752 | [
"DDInter1460",
"DDInter380"
] | Phenytoin | Cimetidine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Major | 2 | [
[
[
362,
25,
752
]
],
[
[
362,
6,
21998
],
[
21998,
45,
752
]
],
[
[
362,
21,
29134
],
[
29134,
60,
752
]
],
[
[
362,
24,
112
],
[
112,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cimetidine"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {v} (Compound)"... | Phenytoin (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cimetidine (Compound)
Phenytoin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB00215 | DB01218 | 1,230 | 1,493 | [
"DDInter388",
"DDInter852"
] | Citalopram | Halofantrine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
1230,
25,
1493
]
],
[
[
1230,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
1230,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
1230,
23,
112
],
[
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Halof... | Citalopram (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Citalopram (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Citalopram may cause a minor interaction that can limit clinical effects when take... |
DB00341 | DB09420 | 1,242 | 1,074 | [
"DDInter343",
"DDInter953"
] | Cetirizine | Iodide I-123 | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1242,
24,
1074
]
],
[
[
1242,
24,
849
],
[
849,
24,
1074
]
],
[
[
1242,
40,
1413
],
[
1413,
24,
1074
]
],
[
[
1242,
63,
905
],
[
905,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Cetirizine (Compound) resembles Fexofenadine (Compound) and Fexofenadine may cause a moderate interaction that... |
DB01181 | DB11627 | 1,532 | 1,367 | [
"DDInter906",
"DDInter860"
] | Ifosfamide | Hepatitis B Vaccine (Recombinant) | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1532,
24,
1367
]
],
[
[
1532,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
1532,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
1532,
24,
259
],
[
259... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alde... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Ifosfamide may lead to a major life threatening interaction when taken with Cladribine ... |
DB00352 | DB06168 | 482 | 1,531 | [
"DDInter1814",
"DDInter281"
] | Tioguanine | Canakinumab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
482,
24,
1531
]
],
[
[
482,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
482,
63,
377
],
[
377,
24,
1531
]
],
[
[
482,
24,
1270
],
[
1270,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin ... |
DB01039 | DB01097 | 535 | 1,377 | [
"DDInter718",
"DDInter1033"
] | Fenofibrate | Leflunomide | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
535,
25,
1377
]
],
[
[
535,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
535,
21,
29405
],
[
29405,
60,
1377
]
],
[
[
535,
64,
126
],
[
126,
... | [
[
[
"Fenofibrate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Fenofibrate",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Lefl... | Fenofibrate (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Fenofibrate (Compound) causes Raised liver function tests (Side Effect) and Raised liver function tests (Side Effect) is caused by Leflunomide (Compound)
Fenofibrate may lead to a major life threatening interaction when take... |
DB01229 | DB09048 | 973 | 555 | [
"DDInter1377",
"DDInter1284"
] | Paclitaxel | Netupitant | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
973,
24,
555
]
],
[
[
973,
63,
1101
],
[
1101,
23,
555
]
],
[
[
973,
24,
283
],
[
283,
62,
555
]
],
[
[
973,
63,
63
],
[
63,
24,... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratin... |
DB09079 | DB09122 | 1,496 | 1,613 | [
"DDInter1296",
"DDInter1409"
] | Nintedanib | Peginterferon beta-1a | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1496,
24,
1613
]
],
[
[
1496,
63,
1627
],
[
1627,
24,
1613
]
],
[
[
1496,
24,
1155
],
[
1155,
63,
1613
]
],
[
[
1496,
64,
651
],
[
651... | [
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
... | Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Tucatini... |
DB01377 | DB11799 | 1,283 | 627 | [
"DDInter1119",
"DDInter205"
] | Magnesium oxide | Bictegravir | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Major | 2 | [
[
[
1283,
25,
627
]
],
[
[
1283,
24,
478
],
[
478,
24,
627
]
],
[
[
1283,
62,
891
],
[
891,
24,
627
]
],
[
[
1283,
24,
1406
],
[
1406,
... | [
[
[
"Magnesium oxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bictegravir"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
"... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Prednisolone a... |
DB00570 | DB14443 | 147 | 987 | [
"DDInter1936",
"DDInter1931"
] | Vinblastine | Vibrio cholerae CVD 103-HgR strain live antigen | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
147,
24,
987
]
],
[
[
147,
24,
1480
],
[
1480,
24,
987
]
],
[
[
147,
63,
141
],
[
141,
24,
987
]
],
[
[
147,
25,
384
],
[
384,
2... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Vinblastine may cause a moderate interaction that could exacerbate diseases wh... |
DB00352 | DB00530 | 482 | 1,195 | [
"DDInter1814",
"DDInter667"
] | Tioguanine | Erlotinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
482,
24,
1195
]
],
[
[
482,
63,
883
],
[
883,
40,
1195
]
],
[
[
482,
21,
28658
],
[
28658,
60,
1195
]
],
[
[
482,
24,
1622
],
[
1622,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Tioguanine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Erlotinib (Compound)
Tioguanine may cause a moderate interaction that c... |
DB00656 | DB00792 | 827 | 832 | [
"DDInter1851",
"DDInter1878"
] | Trazodone | Tripelennamine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
827,
24,
832
]
],
[
[
827,
24,
100
],
[
100,
63,
832
]
],
[
[
827,
25,
1264
],
[
1264,
63,
832
]
],
[
[
827,
24,
649
],
[
649,
1... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Trazodone may lead to a major life threatening interaction when taken with Doxepin and Doxepin may ... |
DB01208 | DB01211 | 945 | 609 | [
"DDInter1705",
"DDInter393"
] | Sparfloxacin | Clarithromycin | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
945,
25,
609
]
],
[
[
945,
6,
4973
],
[
4973,
45,
609
]
],
[
[
945,
18,
2183
],
[
2183,
57,
609
]
],
[
[
945,
21,
28662
],
[
28662,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"C... | Sparfloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Sparfloxacin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Clarithromycin (Compound)
Sparfloxacin (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Co... |
DB00450 | DB00704 | 78 | 267 | [
"DDInter603",
"DDInter1263"
] | Droperidol | Naltrexone | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Major | 2 | [
[
[
78,
25,
267
]
],
[
[
78,
25,
173
],
[
173,
1,
267
]
],
[
[
78,
64,
475
],
[
475,
25,
267
]
],
[
[
78,
21,
28787
],
[
28787,
60,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naltrexone"
]
],
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxone"
],
[
"Naloxone",
"{u} (Comp... | Droperidol may lead to a major life threatening interaction when taken with Naloxone and Naloxone (Compound) resembles Naltrexone (Compound)
Droperidol may lead to a major life threatening interaction when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Naltrexone
Drope... |
DB01246 | DB11732 | 820 | 1,097 | [
"DDInter45",
"DDInter1027"
] | Alimemazine | Lasmiditan | A phenothiazine derivative that is used as an antipruritic. | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
820,
24,
1097
]
],
[
[
820,
24,
971
],
[
971,
63,
1097
]
],
[
[
820,
63,
77
],
[
77,
24,
1097
]
],
[
[
820,
25,
478
],
[
478,
24... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and ... |
DB00524 | DB01070 | 811 | 1,098 | [
"DDInter1199",
"DDInter558"
] | Metolazone | Dihydrotachysterol | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
811,
24,
1098
]
],
[
[
811,
63,
386
],
[
386,
25,
1098
]
],
[
[
811,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
811,
24,
603
],
[
603,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol and P... |
DB08867 | DB12141 | 807 | 971 | [
"DDInter1897",
"DDInter817"
] | Ulipristal | Gilteritinib | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
807,
24,
971
]
],
[
[
807,
23,
1135
],
[
1135,
23,
971
]
],
[
[
807,
63,
1181
],
[
1181,
24,
971
]
],
[
[
807,
24,
1017
],
[
1017,
... | [
[
[
"Ulipristal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Ulipristal",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Ulipristal may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Ulipristal may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadi... |
DB00277 | DB00533 | 1,031 | 1,416 | [
"DDInter1791",
"DDInter1613"
] | Theophylline | Rofecoxib | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Moderate | 1 | [
[
[
1031,
24,
1416
]
],
[
[
1031,
24,
167
],
[
167,
63,
1416
]
],
[
[
1031,
63,
912
],
[
912,
24,
1416
]
],
[
[
1031,
24,
251
],
[
251,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rofecoxib"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Interferon... |
DB00331 | DB00668 | 1,645 | 874 | [
"DDInter1164",
"DDInter652"
] | Metformin | Epinephrine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1645,
24,
874
]
],
[
[
1645,
24,
1636
],
[
1636,
1,
874
]
],
[
[
1645,
24,
688
],
[
688,
63,
874
]
],
[
[
1645,
6,
10715
],
[
10715,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that ... |
DB00022 | DB00563 | 268 | 663 | [
"DDInter1408",
"DDInter1174"
] | Peginterferon alfa-2b | Methotrexate | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
268,
24,
663
]
],
[
[
268,
24,
126
],
[
126,
62,
663
]
],
[
[
268,
24,
738
],
[
738,
63,
663
]
],
[
[
268,
25,
876
],
[
876,
63,... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"War... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Nir... |
DB00912 | DB01089 | 473 | 1,340 | [
"DDInter1581",
"DDInter502"
] | Repaglinide | Deserpidine | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Moderate | 1 | [
[
[
473,
24,
1340
]
],
[
[
473,
63,
1245
],
[
1245,
40,
1340
]
],
[
[
473,
63,
1445
],
[
1445,
24,
1340
]
],
[
[
473,
24,
1220
],
[
1220,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpine"
],
[
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Reserpine and Reserpine (Compound) resembles Deserpidine (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction... |
DB00514 | DB09039 | 506 | 1,670 | [
"DDInter527",
"DDInter629"
] | Dextromethorphan | Eliglustat | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
506,
24,
1670
]
],
[
[
506,
25,
121
],
[
121,
24,
1670
]
],
[
[
506,
24,
1664
],
[
1664,
24,
1670
]
],
[
[
506,
63,
288
],
[
288,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Dextromethorphan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
],
[
... | Dextromethorphan may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risp... |
DB00363 | DB00889 | 695 | 1,133 | [
"DDInter419",
"DDInter840"
] | Clozapine | Granisetron | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
695,
25,
1133
]
],
[
[
695,
24,
19
],
[
19,
40,
1133
]
],
[
[
695,
24,
85
],
[
85,
1,
1133
]
],
[
[
695,
6,
8374
],
[
8374,
45,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamin... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Compound)
Cl... |
DB00861 | DB06228 | 914 | 792 | [
"DDInter551",
"DDInter1609"
] | Diflunisal | Rivaroxaban | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
914,
25,
792
]
],
[
[
914,
7,
7483
],
[
7483,
46,
792
]
],
[
[
914,
21,
28703
],
[
28703,
60,
792
]
],
[
[
914,
24,
738
],
[
738,
... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Diflunisal",
"{u} (Compound) upregulates {v} (Gene)",
"HLA-DMA"
],
[
"HLA-DMA",
"{u} (Gene) is upregulated by {v} (Compound)",... | Diflunisal (Compound) upregulates HLA-DMA (Gene) and HLA-DMA (Gene) is upregulated by Rivaroxaban (Compound)
Diflunisal (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Nirap... |
DB01004 | DB06589 | 563 | 1,250 | [
"DDInter806",
"DDInter1400"
] | Ganciclovir | Pazopanib | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
563,
24,
1250
]
],
[
[
563,
21,
29264
],
[
29264,
60,
1250
]
],
[
[
563,
63,
1419
],
[
1419,
24,
1250
]
],
[
[
563,
24,
4
],
[
4,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Ganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Rhinorrhoea"
],
[
"Rhinorrhoea",
"{u} (Side Effect) is... | Ganciclovir (Compound) causes Rhinorrhoea (Side Effect) and Rhinorrhoea (Side Effect) is caused by Pazopanib (Compound)
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Pazopa... |
DB01036 | DB01259 | 211 | 392 | [
"DDInter1832",
"DDInter1024"
] | Tolterodine | Lapatinib | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
211,
24,
392
]
],
[
[
211,
6,
8374
],
[
8374,
45,
392
]
],
[
[
211,
21,
28757
],
[
28757,
60,
392
]
],
[
[
211,
24,
918
],
[
918,
... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Tolterodine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Tolterodine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Tolterodine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Lapatinib (Compound)
Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and B... |
DB01142 | DB01182 | 1,264 | 371 | [
"DDInter593",
"DDInter1534"
] | Doxepin | Propafenone | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
1264,
24,
371
]
],
[
[
1264,
62,
847
],
[
847,
1,
371
]
],
[
[
1264,
64,
704
],
[
704,
1,
371
]
],
[
[
1264,
63,
772
],
[
772,
4... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Atomoxetine"
],
[
"A... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Doxepin may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Propafenone (Compound)
Doxepin may cause a mod... |
DB00900 | DB01097 | 45 | 1,377 | [
"DDInter544",
"DDInter1033"
] | Didanosine | Leflunomide | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
45,
25,
1377
]
],
[
[
45,
21,
28701
],
[
28701,
60,
1377
]
],
[
[
45,
63,
597
],
[
597,
24,
1377
]
],
[
[
45,
24,
112
],
[
112,
... | [
[
[
"Didanosine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Didanosine",
"{u} (Compound) causes {v} (Side Effect)",
"Discomfort"
],
[
"Discomfort",
"{u} (Side Effect) is caused by {v} (C... | Didanosine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Leflunomide (Compound)
Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken... |
DB00757 | DB06699 | 1,166 | 774 | [
"DDInter581",
"DDInter493"
] | Dolasetron | Degarelix | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Major | 2 | [
[
[
1166,
25,
774
]
],
[
[
1166,
64,
521
],
[
521,
1,
774
]
],
[
[
1166,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1166,
23,
112
],
[
112,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Degarelix"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Goserelin"
],
[
"Goserelin",
"{u} (Com... | Dolasetron may lead to a major life threatening interaction when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Dolasetron (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Dolasetron may cause a minor interaction that can limit clinica... |
DB00214 | DB00912 | 1,028 | 473 | [
"DDInter1836",
"DDInter1581"
] | Torasemide | Repaglinide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1028,
24,
473
]
],
[
[
1028,
6,
3486
],
[
3486,
45,
473
]
],
[
[
1028,
21,
28873
],
[
28873,
60,
473
]
],
[
[
1028,
24,
1026
],
[
1026... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Torasemide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Torasemide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Repaglinide (Compound)
Torasemide (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone... |
DB00041 | DB01023 | 1,648 | 409 | [
"DDInter38",
"DDInter716"
] | Aldesleukin | Felodipine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
1648,
24,
409
]
],
[
[
1648,
24,
376
],
[
376,
40,
409
]
],
[
[
1648,
24,
1428
],
[
1428,
1,
409
]
],
[
[
1648,
24,
407
],
[
407,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Felodipine (Compound... |
DB00911 | DB01357 | 458 | 890 | [
"DDInter1811",
"DDInter1160"
] | Tinidazole | Mestranol | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
458,
24,
890
]
],
[
[
458,
63,
1438
],
[
1438,
1,
890
]
],
[
[
458,
62,
752
],
[
752,
23,
890
]
],
[
[
458,
63,
126
],
[
126,
24... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Mestranol (Compound)
Tinidazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit cli... |
DB01044 | DB01611 | 246 | 1,487 | [
"DDInter809",
"DDInter893"
] | Gatifloxacin | Hydroxychloroquine | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
246,
25,
1487
]
],
[
[
246,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
246,
7,
2216
],
[
2216,
46,
1487
]
],
[
[
246,
21,
28658
],
[
28658,... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Gatifloxacin may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Gatifloxacin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Hydroxychloroquine (Compound)
Gatifloxacin (Compou... |
DB00889 | DB14568 | 1,133 | 982 | [
"DDInter840",
"DDInter1000"
] | Granisetron | Ivosidenib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1133,
25,
982
]
],
[
[
1133,
23,
112
],
[
112,
23,
982
]
],
[
[
1133,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1133,
63,
543
],
[
543,
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Be... |
DB00059 | DB13928 | 1,560 | 1,385 | [
"DDInter1404",
"DDInter1660"
] | Pegaspargase | Semaglutide | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1560,
24,
1385
]
],
[
[
1560,
24,
1154
],
[
1154,
24,
1385
]
],
[
[
1560,
63,
1685
],
[
1685,
24,
1385
]
],
[
[
1560,
25,
695
],
[
695... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Insulin human ... |
DB00734 | DB09080 | 1,664 | 144 | [
"DDInter1605",
"DDInter1331"
] | Risperidone | Olodaterol | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1664,
24,
144
]
],
[
[
1664,
25,
1011
],
[
1011,
24,
144
]
],
[
[
1664,
64,
11
],
[
11,
24,
144
]
],
[
[
1664,
24,
543
],
[
543,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Risperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolim... | Risperidone may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Risperidone may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate in... |
DB00363 | DB00761 | 695 | 1,621 | [
"DDInter419",
"DDInter1497"
] | Clozapine | Potassium chloride | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
695,
25,
1621
]
],
[
[
695,
63,
1685
],
[
1685,
23,
1621
]
],
[
[
695,
24,
1254
],
[
1254,
62,
1621
]
],
[
[
695,
40,
1408
],
[
1408,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin human"
],
[
"I... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a minor interaction that can limit clinical effects when taken with Potassium chloride
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glu... |
DB00888 | DB06688 | 1,001 | 1,430 | [
"DDInter1133",
"DDInter1677"
] | Mechlorethamine | Sipuleucel-T | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1001,
24,
1430
]
],
[
[
1001,
63,
51
],
[
51,
24,
1430
]
],
[
[
1001,
24,
869
],
[
869,
24,
1430
]
],
[
[
1001,
25,
676
],
[
676,
... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Topot... |
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