drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00215 | DB08816 | 1,230 | 578 | [
"DDInter388",
"DDInter1802"
] | Citalopram | Ticagrelor | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1230,
24,
578
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
578
]
],
[
[
1230,
21,
28646
],
[
28646,
60,
578
]
],
[
[
1230,
25,
1011
],
[
1011... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Citalopram (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Citalopram may lead to a m... |
DB00968 | DB01097 | 1,551 | 1,377 | [
"DDInter1185",
"DDInter1033"
] | Methyldopa | Leflunomide | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1551,
25,
1377
]
],
[
[
1551,
18,
14025
],
[
14025,
57,
1377
]
],
[
[
1551,
21,
29231
],
[
29231,
60,
1377
]
],
[
[
1551,
1,
1191
],
[
... | [
[
[
"Methyldopa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Methyldopa",
"{u} (Compound) downregulates {v} (Gene)",
"ACOT9"
],
[
"ACOT9",
"{u} (Gene) is downregulated by {v} (Compound)",... | Methyldopa (Compound) downregulates ACOT9 (Gene) and ACOT9 (Gene) is downregulated by Leflunomide (Compound)
Methyldopa (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Leflunomide (Compound)
Methyldopa (Compound) resembles Levodopa (Compound) and Levodopa may cause a mod... |
DB01174 | DB11718 | 697 | 927 | [
"DDInter1442",
"DDInter640"
] | Phenobarbital | Encorafenib | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
697,
25,
927
]
],
[
[
697,
63,
112
],
[
112,
23,
927
]
],
[
[
697,
1,
536
],
[
536,
24,
927
]
],
[
[
697,
25,
1491
],
[
1491,
24... | [
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Phenobarbital (Compound) resembles Secobarbital (Compound) and Secobarbital may cause a moderate interac... |
DB00533 | DB09134 | 1,416 | 1,552 | [
"DDInter1613",
"DDInter966"
] | Rofecoxib | Ioversol | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
1416,
25,
1552
]
],
[
[
1416,
24,
848
],
[
848,
25,
1552
]
],
[
[
1416,
25,
629
],
[
629,
25,
1552
]
],
[
[
1416,
63,
1645
],
[
1645,
... | [
[
[
"Rofecoxib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibuprofen",
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead to a major life threatening interaction when taken with Ioversol
Rofecoxib may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may lead to a major life threaten... |
DB00281 | DB00400 | 608 | 353 | [
"DDInter1066",
"DDInter843"
] | Lidocaine | Griseofulvin | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Minor | 0 | [
[
[
608,
23,
353
]
],
[
[
608,
6,
8374
],
[
8374,
45,
353
]
],
[
[
608,
18,
15501
],
[
15501,
57,
353
]
],
[
[
608,
21,
28745
],
[
28745,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Griseofulvin"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Griseofulvin (Compound)
Lidocaine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Griseofulvin (Compound)
Lidocaine (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused ... |
DB04845 | DB09276 | 309 | 381 | [
"DDInter1001",
"DDInter1682"
] | Ixabepilone | Sodium aurothiomalate | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
309,
24,
381
]
],
[
[
309,
24,
1683
],
[
1683,
24,
381
]
],
[
[
309,
63,
491
],
[
491,
24,
381
]
],
[
[
309,
25,
375
],
[
375,
2... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Pegint... |
DB11248 | DB11943 | 1,193 | 255 | [
"DDInter1965",
"DDInter495"
] | Zinc gluconate | Delafloxacin | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wit... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1193,
24,
255
]
],
[
[
1193,
62,
1307
],
[
1307,
23,
255
]
],
[
[
1193,
62,
1596
],
[
1596,
24,
255
]
],
[
[
1193,
23,
428
],
[
428,
... | [
[
[
"Zinc gluconate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Melphalan"
],
... | Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Iron and Iron may c... |
DB00448 | DB09098 | 1,215 | 98 | [
"DDInter1022",
"DDInter1700"
] | Lansoprazole | Somatrem | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1215,
24,
98
]
],
[
[
1215,
24,
1671
],
[
1671,
24,
98
]
],
[
[
1215,
24,
1580
],
[
1580,
63,
98
]
],
[
[
1215,
23,
785
],
[
785,
... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
],
[... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol and S... |
DB00996 | DB01246 | 1,198 | 820 | [
"DDInter791",
"DDInter45"
] | Gabapentin | Alimemazine | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1198,
24,
820
]
],
[
[
1198,
24,
401
],
[
401,
24,
820
]
],
[
[
1198,
24,
649
],
[
649,
1,
820
]
],
[
[
1198,
18,
5833
],
[
5833,
... | [
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and C... |
DB09085 | DB09112 | 587 | 1,455 | [
"DDInter1779",
"DDInter1306"
] | Tetracaine | Nitrous acid | Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch. | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
587,
25,
1455
]
],
[
[
587,
63,
161
],
[
161,
25,
1455
]
],
[
[
587,
63,
161
],
[
161,
1,
698
],
[
698,
25,
1455
]
],
[
[
587,
6... | [
[
[
"Tetracaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Tetracaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
],
[
"Sulfad... | Tetracaine may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine may lead to a major life threatening interaction when taken with Nitrous acid
Tetracaine may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine ... |
DB06176 | DB08867 | 1,342 | 807 | [
"DDInter1616",
"DDInter1897"
] | Romidepsin | Ulipristal | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Moderate | 1 | [
[
[
1342,
24,
807
]
],
[
[
1342,
63,
600
],
[
600,
23,
807
]
],
[
[
1342,
24,
1017
],
[
1017,
63,
807
]
],
[
[
1342,
64,
478
],
[
478,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlat... |
DB06674 | DB06688 | 908 | 1,430 | [
"DDInter837",
"DDInter1677"
] | Golimumab | Sipuleucel-T | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
908,
24,
1430
]
],
[
[
908,
64,
175
],
[
175,
24,
1430
]
],
[
[
908,
25,
676
],
[
676,
63,
1430
]
],
[
[
908,
63,
491
],
[
491,
... | [
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamci... | Golimumab may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Golimumab may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a mod... |
DB01015 | DB08820 | 1,247 | 1,478 | [
"DDInter1724",
"DDInter997"
] | Sulfamethoxazole | Ivacaftor | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1247,
24,
1478
]
],
[
[
1247,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1247,
54,
19230
],
[
19230,
15,
1478
]
],
[
[
1247,
21,
29221
],
[
... | [
[
[
"Sulfamethoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (... | Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Sulfamethoxazole (Compound) is included by Cytochrome P450 2C9 Inhibitors (Pharmacologic Class) and Cytochrome P450 2C9 Inhibitors (Pharmacologic Class) includes Ivacaftor (Compound)
Sulfamethoxazole (Compound) causes Inf... |
DB01126 | DB08816 | 1,260 | 578 | [
"DDInter611",
"DDInter1802"
] | Dutasteride | Ticagrelor | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1260,
24,
578
]
],
[
[
1260,
6,
8374
],
[
8374,
45,
578
]
],
[
[
1260,
21,
28894
],
[
28894,
60,
578
]
],
[
[
1260,
63,
723
],
[
723,
... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Dutasteride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Dutasteride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Dutasteride (Compound) causes Cardiac failure (Side Effect) and Cardiac failure (Side Effect) is caused by Ticagrelor (Compound)
Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Apre... |
DB00618 | DB01603 | 1,572 | 1,366 | [
"DDInter498",
"DDInter1195"
] | Demeclocycline | Meticillin | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. | Moderate | 1 | [
[
[
1572,
24,
1366
]
],
[
[
1572,
63,
790
],
[
790,
40,
1366
]
],
[
[
1572,
24,
950
],
[
950,
40,
1366
]
],
[
[
1572,
24,
339
],
[
339,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meticillin"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piperacillin"
]... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Piperacillin and Piperacillin (Compound) resembles Meticillin (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembles Meticill... |
DB00661 | DB11348 | 122 | 1,065 | [
"DDInter1928",
"DDInter279"
] | Verapamil | Calcium Phosphate | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
122,
24,
1065
]
],
[
[
122,
25,
1135
],
[
1135,
23,
943
],
[
943,
63,
1065
]
],
[
[
122,
25,
1456
],
[
1456,
24,
943
],
[
943,
63,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxe... | Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Sarecycline and Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Verapamil may lea... |
DB05294 | DB15093 | 1,069 | 1,654 | [
"DDInter1917",
"DDInter1698"
] | Vandetanib | Somapacitan | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1069,
24,
1654
]
],
[
[
1069,
62,
1215
],
[
1215,
24,
1654
]
],
[
[
1069,
23,
1135
],
[
1135,
24,
1654
]
],
[
[
1069,
25,
351
],
[
351... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lansoprazole"
],
[
... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Lansoprazole and Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Vandetanib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxe... |
DB00046 | DB00584 | 1,179 | 610 | [
"DDInter940",
"DDInter638"
] | Insulin lispro | Enalapril | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Moderate | 1 | [
[
[
1179,
24,
610
]
],
[
[
1179,
24,
743
],
[
743,
1,
610
]
],
[
[
1179,
24,
954
],
[
954,
40,
610
]
],
[
[
1179,
24,
590
],
[
590,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Enalapril (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Enalapril (Compou... |
DB00087 | DB01234 | 599 | 1,220 | [
"DDInter41",
"DDInter513"
] | Alemtuzumab | Dexamethasone | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
599,
24,
1220
]
],
[
[
599,
24,
870
],
[
870,
1,
1220
]
],
[
[
599,
24,
175
],
[
175,
40,
1220
]
],
[
[
599,
24,
510
],
[
510,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles D... |
DB00371 | DB00405 | 1,050 | 128 | [
"DDInter1154",
"DDInter517"
] | Meprobamate | Dexbrompheniramine | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
1050,
24,
128
]
],
[
[
1050,
24,
662
],
[
662,
63,
128
]
],
[
[
1050,
64,
475
],
[
475,
24,
128
]
],
[
[
1050,
63,
701
],
[
701,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Meprobamate may lead to a major life threatening interaction when taken with Morphine and Morphin... |
DB06335 | DB14568 | 761 | 982 | [
"DDInter1646",
"DDInter1000"
] | Saxagliptin | Ivosidenib | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
761,
24,
982
]
],
[
[
761,
63,
168
],
[
168,
23,
982
]
],
[
[
761,
64,
1101
],
[
1101,
23,
982
]
],
[
[
761,
24,
241
],
[
241,
2... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Saxagliptin may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause ... |
DB01088 | DB01191 | 714 | 1,039 | [
"DDInter908",
"DDInter518"
] | Iloprost | Dexfenfluramine | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
714,
24,
1039
]
],
[
[
714,
24,
1046
],
[
1046,
63,
1039
]
],
[
[
714,
25,
500
],
[
500,
63,
1039
]
],
[
[
714,
63,
935
],
[
935,
... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caplacizumab"
],
[... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Iloprost may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may c... |
DB00736 | DB11837 | 660 | 1,297 | [
"DDInter676",
"DDInter1351"
] | Esomeprazole | Osilodrostat | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
660,
24,
1297
]
],
[
[
660,
24,
307
],
[
307,
24,
1297
]
],
[
[
660,
63,
789
],
[
789,
24,
1297
]
],
[
[
660,
40,
837
],
[
837,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Fos... |
DB00455 | DB10429 | 1,601 | 200 | [
"DDInter1091",
"DDInter282"
] | Loratadine | Candida albicans | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1601,
24,
200
]
],
[
[
1601,
24,
1619
],
[
1619,
63,
200
]
],
[
[
1601,
24,
1213
],
[
1213,
24,
200
]
],
[
[
1601,
24,
1619
],
[
1619,... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
... | Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Das... |
DB00220 | DB12267 | 798 | 1,476 | [
"DDInter1276",
"DDInter233"
] | Nelfinavir | Brigatinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
798,
25,
1476
]
],
[
[
798,
25,
1135
],
[
1135,
23,
1476
]
],
[
[
798,
63,
168
],
[
168,
23,
1476
]
],
[
[
798,
25,
629
],
[
629,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Nelfinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a mi... |
DB00285 | DB00405 | 1,100 | 128 | [
"DDInter1927",
"DDInter517"
] | Venlafaxine | Dexbrompheniramine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
1100,
24,
128
]
],
[
[
1100,
24,
662
],
[
662,
63,
128
]
],
[
[
1100,
24,
28
],
[
28,
1,
128
]
],
[
[
1100,
25,
222
],
[
222,
63... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Bisac... |
DB00731 | DB01277 | 1,144 | 1,022 | [
"DDInter1269",
"DDInter1131"
] | Nateglinide | Mecasermin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human I... | Moderate | 1 | [
[
[
1144,
24,
1022
]
],
[
[
1144,
24,
1411
],
[
1411,
24,
1022
]
],
[
[
1144,
63,
590
],
[
590,
24,
1022
]
],
[
[
1144,
24,
1411
],
[
1411... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mecasermin"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
[... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Mecasermin
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and... |
DB06688 | DB08870 | 1,430 | 850 | [
"DDInter1677",
"DDInter228"
] | Sipuleucel-T | Brentuximab vedotin | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1430,
24,
850
]
],
[
[
1430,
63,
611
],
[
611,
24,
850
]
],
[
[
1430,
24,
1583
],
[
1583,
63,
850
]
],
[
[
1430,
24,
310
],
[
310,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine and Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Sarilu... |
DB04575 | DB12010 | 35 | 214 | [
"DDInter1555",
"DDInter785"
] | Quinestrol | Fostamatinib | The 3-cyclopentyl ether of ethinyl estradiol. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
35,
24,
214
]
],
[
[
35,
63,
723
],
[
723,
24,
214
]
],
[
[
35,
40,
1197
],
[
1197,
24,
214
]
],
[
[
35,
24,
1017
],
[
1017,
63,... | [
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Quinestrol (Compound) resembles Norethisterone (Compound) and Norethisterone may cause a moderate interaction ... |
DB01035 | DB06603 | 1,401 | 39 | [
"DDInter1524",
"DDInter1387"
] | Procainamide | Panobinostat | A derivative of procaine with less CNS action. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1401,
25,
39
]
],
[
[
1401,
62,
112
],
[
112,
23,
39
]
],
[
[
1401,
63,
455
],
[
455,
24,
39
]
],
[
[
1401,
24,
1683
],
[
1683,
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Procainamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Procainamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol an... |
DB00465 | DB06081 | 886 | 1,046 | [
"DDInter1010",
"DDInter286"
] | Ketorolac | Caplacizumab | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Moderate | 1 | [
[
[
886,
24,
1046
]
],
[
[
886,
24,
1039
],
[
1039,
24,
1046
]
],
[
[
886,
1,
935
],
[
935,
24,
1046
]
],
[
[
886,
63,
1061
],
[
1061,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caplacizumab"
]
],
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
... | Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab
Ketorolac (Compound) resembles Ketoprofen (Compound) and Ketoprofen may cause a moderate interaction ... |
DB00196 | DB00741 | 600 | 167 | [
"DDInter743",
"DDInter885"
] | Fluconazole | Hydrocortisone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
600,
24,
167
]
],
[
[
600,
25,
312
],
[
312,
24,
167
]
],
[
[
600,
24,
1220
],
[
1220,
40,
167
]
],
[
[
600,
24,
870
],
[
870,
1... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eplerenone"
],
[
"Eple... | Fluconazole may lead to a major life threatening interaction when taken with Eplerenone and Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethason... |
DB00704 | DB00991 | 267 | 97 | [
"DDInter1263",
"DDInter1358"
] | Naltrexone | Oxaprozin | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
267,
24,
97
]
],
[
[
267,
63,
362
],
[
362,
1,
97
]
],
[
[
267,
24,
1274
],
[
1274,
24,
97
]
],
[
[
267,
64,
576
],
[
576,
1,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that coul... |
DB00009 | DB11312 | 1,271 | 298 | [
"DDInter56",
"DDInter1542"
] | Alteplase | Protein C | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Moderate | 1 | [
[
[
1271,
24,
298
]
],
[
[
1271,
25,
707
],
[
707,
24,
298
]
],
[
[
1271,
24,
1416
],
[
1416,
24,
298
]
],
[
[
1271,
64,
942
],
[
942,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
]
],
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparoid",
... | Alteplase may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib and Rofecoxib may cause a mod... |
DB00270 | DB01240 | 1,428 | 885 | [
"DDInter993",
"DDInter657"
] | Isradipine | Epoprostenol | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1428,
24,
885
]
],
[
[
1428,
24,
1061
],
[
1061,
1,
885
]
],
[
[
1428,
21,
28684
],
[
28684,
60,
885
]
],
[
[
1428,
24,
1512
],
[
1512... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Isradipine (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Epoprostenol (Compound)
Isradipine may cause a moder... |
DB00468 | DB01232 | 1,424 | 1,327 | [
"DDInter1557",
"DDInter1640"
] | Quinine | Saquinavir | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
1424,
25,
1327
]
],
[
[
1424,
63,
798
],
[
798,
40,
1327
]
],
[
[
1424,
24,
915
],
[
915,
40,
1327
]
],
[
[
1424,
6,
6648
],
[
6648,
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
Quinin... |
DB08899 | DB13139 | 129 | 1,032 | [
"DDInter649",
"DDInter1063"
] | Enzalutamide | Levosalbutamol | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
129,
24,
1032
]
],
[
[
129,
63,
1220
],
[
1220,
23,
1032
]
],
[
[
129,
64,
1618
],
[
1618,
24,
1032
]
],
[
[
129,
25,
124
],
[
124,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Enzalutamide may lead to a major life threatening interaction when taken with Cabozantinib and Cabozan... |
DB01236 | DB08899 | 679 | 129 | [
"DDInter1664",
"DDInter649"
] | Sevoflurane | Enzalutamide | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
679,
24,
129
]
],
[
[
679,
63,
918
],
[
918,
1,
129
]
],
[
[
679,
6,
8374
],
[
8374,
45,
129
]
],
[
[
679,
21,
28703
],
[
28703,
... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Sevoflurane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Sevoflurane (Compound) causes Pruritus (Side Effect) and... |
DB00182 | DB01001 | 80 | 688 | [
"DDInter84",
"DDInter1632"
] | Amphetamine | Salbutamol | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
80,
24,
688
]
],
[
[
80,
24,
874
],
[
874,
24,
688
]
],
[
[
80,
24,
1148
],
[
1148,
63,
688
]
],
[
[
80,
21,
28714
],
[
28714,
6... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB00555 | DB11130 | 706 | 407 | [
"DDInter1020",
"DDInter1344"
] | Lamotrigine | Opium | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
706,
24,
407
]
],
[
[
706,
24,
662
],
[
662,
24,
407
]
],
[
[
706,
63,
1233
],
[
1233,
24,
407
]
],
[
[
706,
40,
1275
],
[
1275,
... | [
[
[
"Lamotrigine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Lamotrigine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine and T... |
DB00445 | DB01165 | 322 | 1,539 | [
"DDInter655",
"DDInter1325"
] | Epirubicin | Ofloxacin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
322,
24,
1539
]
],
[
[
322,
23,
1467
],
[
1467,
1,
1539
]
],
[
[
322,
64,
1176
],
[
1176,
1,
1539
]
],
[
[
322,
25,
945
],
[
945,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
"... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Epirubicin may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Epirubicin may lead... |
DB00564 | DB06616 | 1,236 | 594 | [
"DDInter293",
"DDInter224"
] | Carbamazepine | Bosutinib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1236,
25,
594
]
],
[
[
1236,
63,
883
],
[
883,
1,
594
]
],
[
[
1236,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1236,
18,
4360
],
[
4360,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefiti... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Carbamazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Carbamazepine (Compound) downregulates TIMM9 (Gene) and TIMM9 (G... |
DB00726 | DB00889 | 1,164 | 1,133 | [
"DDInter1876",
"DDInter840"
] | Trimipramine | Granisetron | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
1164,
25,
1133
]
],
[
[
1164,
63,
19
],
[
19,
40,
1133
]
],
[
[
1164,
63,
85
],
[
85,
1,
1133
]
],
[
[
1164,
6,
8374
],
[
8374,
... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyos... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Compou... |
DB00574 | DB00867 | 121 | 1,052 | [
"DDInter717",
"DDInter1606"
] | Fenfluramine | Ritodrine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Adrenergic beta-agonist used to control premature labor. | Moderate | 1 | [
[
[
121,
24,
1052
]
],
[
[
121,
24,
1148
],
[
1148,
63,
1052
]
],
[
[
121,
64,
1466
],
[
1466,
24,
1052
]
],
[
[
121,
63,
245
],
[
245,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine
Fenfluramine may lead to a major life threatening interaction when taken with Phenylpropanolamine and Pheny... |
DB00041 | DB01162 | 1,648 | 195 | [
"DDInter38",
"DDInter1767"
] | Aldesleukin | Terazosin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Moderate | 1 | [
[
[
1648,
24,
195
]
],
[
[
1648,
24,
1205
],
[
1205,
40,
195
]
],
[
[
1648,
24,
475
],
[
475,
24,
195
]
],
[
[
1648,
24,
1220
],
[
1220,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Terazosin (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacer... |
DB06788 | DB09083 | 1,616 | 880 | [
"DDInter864",
"DDInter996"
] | Histrelin | Ivabradine | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
1616,
25,
880
]
],
[
[
1616,
63,
480
],
[
480,
24,
880
]
],
[
[
1616,
24,
659
],
[
659,
24,
880
]
],
[
[
1616,
25,
1011
],
[
1011,
... | [
[
[
"Histrelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol",... | Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanter... |
DB00902 | DB08815 | 104 | 154 | [
"DDInter1168",
"DDInter1104"
] | Methdilazine | Lurasidone | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
104,
24,
154
]
],
[
[
104,
24,
1532
],
[
1532,
24,
154
]
],
[
[
104,
63,
1242
],
[
1242,
24,
154
]
],
[
[
104,
24,
1385
],
[
1385,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Ce... |
DB00262 | DB15965 | 552 | 1,330 | [
"DDInter302",
"DDInter1270"
] | Carmustine | Naxitamab | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
552,
24,
1330
]
],
[
[
552,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
552,
25,
770
],
[
770,
24,
1330
]
],
[
[
552,
63,
1184
],
[
1184,
... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Carmustine may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause... |
DB00653 | DB06817 | 544 | 809 | [
"DDInter1120",
"DDInter1563"
] | Magnesium sulfate | Raltegravir | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. | Moderate | 1 | [
[
[
544,
24,
809
]
],
[
[
544,
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28936
],
[
28936,
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809
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[
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[
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],
[
[
544,
24,
1473
],
[
1473,
... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Raltegravir"
]
],
[
[
"Magnesium sulfate",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperhidrosis"
],
[
"Hyperhidrosis",
"{u... | Magnesium sulfate (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Raltegravir (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effe... |
DB00704 | DB01083 | 267 | 1,142 | [
"DDInter1263",
"DDInter1348"
] | Naltrexone | Orlistat | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Moderate | 1 | [
[
[
267,
24,
1142
]
],
[
[
267,
7,
3163
],
[
3163,
46,
1142
]
],
[
[
267,
21,
28645
],
[
28645,
60,
1142
]
],
[
[
267,
24,
45
],
[
45,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
]
],
[
[
"Naltrexone",
"{u} (Compound) upregulates {v} (Gene)",
"TSC22D3"
],
[
"TSC22D3",
"{u} (Gene) is upregulated by {v} ... | Naltrexone (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Orlistat (Compound)
Naltrexone (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Orlistat (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Di... |
DB00520 | DB00563 | 1,358 | 663 | [
"DDInter306",
"DDInter1174"
] | Caspofungin | Methotrexate | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1358,
24,
663
]
],
[
[
1358,
6,
13478
],
[
13478,
45,
663
]
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[
[
1358,
21,
28681
],
[
28681,
60,
663
]
],
[
[
1358,
24,
1320
],
[
13... | [
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Caspofungin",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B3"
],
[
"SLCO1B3",
"{u} (Gene) is bound by {v} (Compo... | Caspofungin (Compound) binds SLCO1B3 (Gene) and SLCO1B3 (Gene) is bound by Methotrexate (Compound)
Caspofungin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Caspofungin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB06441 | DB11095 | 936 | 235 | [
"DDInter283",
"DDInter505"
] | Cangrelor | Desirudin | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
936,
25,
235
]
],
[
[
936,
23,
297
],
[
297,
23,
235
]
],
[
[
936,
63,
1100
],
[
1100,
24,
235
]
],
[
[
936,
24,
643
],
[
643,
2... | [
[
[
"Cangrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Cangrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} m... | Cangrelor may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Cangrelor may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause ... |
DB00675 | DB01125 | 888 | 279 | [
"DDInter1744",
"DDInter98"
] | Tamoxifen | Anisindione | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Major | 2 | [
[
[
888,
25,
279
]
],
[
[
888,
24,
918
],
[
918,
62,
279
]
],
[
[
888,
24,
913
],
[
913,
63,
279
]
],
[
[
888,
63,
912
],
[
912,
24,... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"Bicalutam... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apal... |
DB00819 | DB09268 | 471 | 1,662 | [
"DDInter15",
"DDInter1464"
] | Acetazolamide | Picosulfuric acid | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
471,
24,
1662
]
],
[
[
471,
1,
997
],
[
997,
24,
1662
]
],
[
[
471,
24,
708
],
[
708,
24,
1662
]
],
[
[
471,
63,
1573
],
[
1573,
... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Acetazolamide",
"{u} (Compound) resembles {v} (Compound)",
"Methazolamide"
],
[
"Methazolamide",
"{u} ... | Acetazolamide (Compound) resembles Methazolamide (Compound) and Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a modera... |
DB00552 | DB11627 | 1,238 | 1,367 | [
"DDInter1425",
"DDInter860"
] | Pentostatin | Hepatitis B Vaccine (Recombinant) | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1238,
24,
1367
]
],
[
[
1238,
1,
1083
],
[
1083,
24,
1367
]
],
[
[
1238,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
1238,
75,
1064
],
[
106... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Pentostatin",
"{u} (Compound) resembles {v} (Compound)",
"Trifluridine"
],
[
"Trifluridine",
... | Pentostatin (Compound) resembles Trifluridine (Compound) and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a ... |
DB06176 | DB10795 | 1,342 | 221 | [
"DDInter1616",
"DDInter1486"
] | Romidepsin | Poliovirus type 1 antigen (formaldehyde inactivated) | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1342,
24,
221
]
],
[
[
1342,
24,
36
],
[
36,
24,
221
]
],
[
[
1342,
64,
581
],
[
581,
24,
221
]
],
[
[
1342,
63,
599
],
[
599,
2... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Romidepsin may lead to a major life threatening interaction when taken wit... |
DB00782 | DB01010 | 1,123 | 61 | [
"DDInter1535",
"DDInter622"
] | Propantheline | Edrophonium | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Moderate | 1 | [
[
[
1123,
24,
61
]
],
[
[
1123,
63,
1636
],
[
1636,
1,
61
]
],
[
[
1123,
24,
768
],
[
768,
40,
61
]
],
[
[
1123,
24,
1372
],
[
1372,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
]... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Edrophonium (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol and Tapentadol (Compound) resembles Edrophoni... |
DB01072 | DB06176 | 915 | 1,342 | [
"DDInter129",
"DDInter1616"
] | Atazanavir | Romidepsin | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
915,
24,
1342
]
],
[
[
915,
25,
1491
],
[
1491,
63,
1342
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],
[
[
915,
24,
1619
],
[
1619,
63,
1342
]
],
[
[
915,
64,
1010
],
[
1010,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
],
[
"Midostaur... | Atazanavir may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause ... |
DB01166 | DB06822 | 477 | 802 | [
"DDInter379",
"DDInter1812"
] | Cilostazol | Tinzaparin | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
477,
25,
802
]
],
[
[
477,
23,
944
],
[
944,
62,
802
]
],
[
[
477,
63,
222
],
[
222,
24,
802
]
],
[
[
477,
24,
1427
],
[
1427,
6... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine... |
DB00188 | DB00395 | 168 | 210 | [
"DDInter222",
"DDInter301"
] | Bortezomib | Carisoprodol | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with ... | Minor | 0 | [
[
[
168,
23,
210
]
],
[
[
168,
6,
10215
],
[
10215,
45,
210
]
],
[
[
168,
21,
28757
],
[
28757,
60,
210
]
],
[
[
168,
25,
913
],
[
913,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Carisoprodol"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)... | Bortezomib (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Carisoprodol (Compound)
Bortezomib (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carisoprodol (Compound)
Bortezomib may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide ... |
DB08868 | DB11569 | 1,011 | 1,093 | [
"DDInter737",
"DDInter1003"
] | Fingolimod | Ixekizumab | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Major | 2 | [
[
[
1011,
25,
1093
]
],
[
[
1011,
64,
66
],
[
66,
24,
1093
]
],
[
[
1011,
24,
496
],
[
496,
24,
1093
]
],
[
[
1011,
63,
376
],
[
376,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Efalizumab"
],
[
"Efalizumab",
"{u} m... | Fingolimod may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A ... |
DB01234 | DB09079 | 1,220 | 1,496 | [
"DDInter513",
"DDInter1296"
] | Dexamethasone | Nintedanib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Major | 2 | [
[
[
1220,
25,
1496
]
],
[
[
1220,
64,
33
],
[
33,
24,
1496
]
],
[
[
1220,
24,
741
],
[
741,
63,
1496
]
],
[
[
1220,
24,
74
],
[
74,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nintedanib"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiodarone",
... | Dexamethasone may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may ... |
DB00976 | DB14723 | 1,056 | 159 | [
"DDInter1758",
"DDInter1026"
] | Telithromycin | Larotrectinib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
1056,
25,
159
]
],
[
[
1056,
24,
222
],
[
222,
23,
159
]
],
[
[
1056,
25,
1135
],
[
1135,
23,
159
]
],
[
[
1056,
63,
63
],
[
63,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Telithromycin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may... |
DB00278 | DB01268 | 291 | 1,151 | [
"DDInter117",
"DDInter1731"
] | Argatroban | Sunitinib | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
291,
24,
1151
]
],
[
[
291,
6,
8374
],
[
8374,
45,
1151
]
],
[
[
291,
21,
28653
],
[
28653,
60,
1151
]
],
[
[
291,
24,
758
],
[
758,
... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Argatroban",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Argatroban (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sunitinib (Compound)
Argatroban (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Sunitinib (Compound)
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fl... |
DB00220 | DB00361 | 798 | 134 | [
"DDInter1276",
"DDInter1939"
] | Nelfinavir | Vinorelbine | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Major | 2 | [
[
[
798,
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[
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[
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[
5360,
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[
[
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"Vinorelbine"
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],
[
[
"Nelfinavir",
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"Vinblastine"
],
[
"Vinblastine",
"{u... | Nelfinavir may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Nelfinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Vinorelbine (Compound)
Nelfinavir (Compound) upregulat... |
DB09241 | DB11823 | 1,629 | 858 | [
"DDInter1186",
"DDInter673"
] | Methylene blue | Esketamine | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Major | 2 | [
[
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[
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[
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"Esketamine"
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],
[
[
"Methylene blue",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextromethorphan"
],
[
"Dextrometho... | Methylene blue may lead to a major life threatening interaction when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Methylene blue may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline a... |
DB01611 | DB13139 | 1,487 | 1,032 | [
"DDInter893",
"DDInter1063"
] | Hydroxychloroquine | Levosalbutamol | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1487,
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[
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[
1133... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Hydroxychloroquine may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib m... |
DB00252 | DB00675 | 362 | 888 | [
"DDInter1460",
"DDInter1744"
] | Phenytoin | Tamoxifen | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
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362,
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]
],
[
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832
],
[
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40,
888
]
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[
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649
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[
649,
1,
888
]
],
[
[
362,
1,
939
],
[
939,
40,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine (Compound) resembles Tamoxifen (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Tamoxifen (Compou... |
DB00095 | DB06643 | 66 | 1,136 | [
"DDInter623",
"DDInter500"
] | Efalizumab | Denosumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
66,
24,
1136
]
],
[
[
66,
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[
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[
[
66,
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1648
],
[
1648,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Durvalumab and Durvaluma... |
DB08889 | DB09122 | 350 | 1,613 | [
"DDInter299",
"DDInter1409"
] | Carfilzomib | Peginterferon beta-1a | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
350,
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],
[
[
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[
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[
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350,
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],
[
1627,
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1613
]
],
[
[
350,
24,
287
],
[
287,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Cannab... |
DB06282 | DB09128 | 516 | 1,241 | [
"DDInter1053",
"DDInter231"
] | Levocetirizine | Brexpiprazole | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
516,
24,
1241
]
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[
[
516,
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407
],
[
407,
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1241
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],
[
[
516,
63,
543
],
[
543,
24,
1241
]
],
[
[
516,
24,
849
],
[
849,
... | [
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
... | Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loper... |
DB06626 | DB08816 | 263 | 578 | [
"DDInter147",
"DDInter1802"
] | Axitinib | Ticagrelor | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
263,
24,
578
]
],
[
[
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63,
336
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[
336,
23,
578
]
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[
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24,
1586
],
[
1586,
62,
578
]
],
[
[
263,
63,
723
],
[
723,
2... | [
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
[
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine and Levamlodi... |
DB00029 | DB00054 | 25 | 1,432 | [
"DDInter99",
"DDInter6"
] | Anistreplase | Abciximab | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Major | 2 | [
[
[
25,
25,
1432
]
],
[
[
25,
23,
539
],
[
539,
62,
1432
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[
[
25,
24,
714
],
[
714,
63,
1432
]
],
[
[
25,
24,
1595
],
[
1595,
24... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abciximab"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Abciximab
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may ... |
DB01097 | DB08826 | 1,377 | 1,292 | [
"DDInter1033",
"DDInter489"
] | Leflunomide | Deferiprone | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1377,
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[
[
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28759
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[
28759,
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[
45,
24,
1292
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[
[
1377,
23,
1193
],
[
1193... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Connective tissue disorder"
],
[
"Connective tissue disorder",
"{u}... | Leflunomide (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Deferiprone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases w... |
DB06372 | DB11767 | 259 | 1,583 | [
"DDInter1594",
"DDInter1643"
] | Rilonacept | Sarilumab | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Major | 2 | [
[
[
259,
25,
1583
]
],
[
[
259,
62,
1461
],
[
1461,
23,
1583
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[
[
259,
23,
1114
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[
1114,
23,
1583
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],
[
[
259,
63,
362
],
[
362,
... | [
[
[
"Rilonacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sarilumab"
]
],
[
[
"Rilonacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Rilonacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Rilonacept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate ... |
DB01115 | DB08904 | 336 | 375 | [
"DDInter1291",
"DDInter342"
] | Nifedipine | Certolizumab pegol | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
336,
24,
375
]
],
[
[
336,
24,
1593
],
[
1593,
24,
375
]
],
[
[
336,
40,
409
],
[
409,
24,
375
]
],
[
[
336,
63,
467
],
[
467,
2... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Nifedipine (Compound) resembles Felodipine (Compound) and Felodipine may cause a moderate interaction th... |
DB00186 | DB09085 | 905 | 587 | [
"DDInter1092",
"DDInter1779"
] | Lorazepam | Tetracaine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch. | Moderate | 1 | [
[
[
905,
24,
587
]
],
[
[
905,
40,
686
],
[
686,
24,
587
]
],
[
[
905,
40,
686
],
[
686,
1,
902
],
[
902,
24,
587
]
],
[
[
905,
40,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracaine"
]
],
[
[
"Lorazepam",
"{u} (Compound) resembles {v} (Compound)",
"Oxazepam"
],
[
"Oxazepam",
"{u} may cause a moderate inte... | Lorazepam (Compound) resembles Oxazepam (Compound) and Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Tetracaine
Lorazepam (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could exa... |
DB00652 | DB09241 | 234 | 1,629 | [
"DDInter1421",
"DDInter1186"
] | Pentazocine | Methylene blue | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
234,
25,
1629
]
],
[
[
234,
24,
1311
],
[
1311,
24,
1629
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[
[
234,
63,
73
],
[
73,
25,
1629
]
],
[
[
234,
1,
1359
],
[
1359,
... | [
[
[
"Pentazocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Phenter... |
DB00289 | DB11986 | 847 | 484 | [
"DDInter132",
"DDInter648"
] | Atomoxetine | Entrectinib | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
847,
24,
484
]
],
[
[
847,
23,
112
],
[
112,
23,
484
]
],
[
[
847,
24,
774
],
[
774,
24,
484
]
],
[
[
847,
1,
1302
],
[
1302,
24... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Atomoxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and De... |
DB00209 | DB13913 | 352 | 1,536 | [
"DDInter1886",
"DDInter175"
] | Trospium | Belladonna | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
352,
24,
1536
]
],
[
[
352,
24,
849
],
[
849,
24,
1536
]
],
[
[
352,
35,
1192
],
[
1192,
24,
1536
]
],
[
[
352,
25,
1621
],
[
1621,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Trospium (Compound) resembles Glycopyrronium (Compound) and Trospium may cause a moderate interaction that could e... |
DB00575 | DB11921 | 1,020 | 1,019 | [
"DDInter412",
"DDInter492"
] | Clonidine | Deflazacort | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1020,
24,
1019
]
],
[
[
1020,
24,
959
],
[
959,
24,
1019
]
],
[
[
1020,
1,
1512
],
[
1512,
24,
1019
]
],
[
[
1020,
24,
877
],
[
877,
... | [
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Clonidine (Compound) resembles Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could ex... |
DB00734 | DB01276 | 1,664 | 123 | [
"DDInter1605",
"DDInter706"
] | Risperidone | Exenatide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1664,
24,
123
]
],
[
[
1664,
24,
820
],
[
820,
24,
123
]
],
[
[
1664,
1,
519
],
[
519,
24,
123
]
],
[
[
1664,
63,
1685
],
[
1685,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Risperidone (Compound) resembles Paliperidone (Compound) and Paliperidone may cause a moderate interaction tha... |
DB00323 | DB01075 | 1,062 | 1,376 | [
"DDInter1829",
"DDInter569"
] | Tolcapone | Diphenhydramine | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1062,
24,
1376
]
],
[
[
1062,
24,
649
],
[
649,
63,
1376
]
],
[
[
1062,
24,
128
],
[
128,
24,
1376
]
],
[
[
1062,
23,
126
],
[
126,
... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine... |
DB00364 | DB01069 | 417 | 401 | [
"DDInter1717",
"DDInter1533"
] | Sucralfate | Promethazine | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Minor | 0 | [
[
[
417,
23,
401
]
],
[
[
417,
23,
146
],
[
146,
24,
401
]
],
[
[
417,
23,
820
],
[
820,
63,
401
]
],
[
[
417,
21,
28775
],
[
28775,
... | [
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Promethazine"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Propiomazine"
],
[
... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Alimemazine and Ali... |
DB00640 | DB06663 | 1,585 | 1,154 | [
"DDInter31",
"DDInter1398"
] | Adenosine | Pasireotide | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1585,
25,
1154
]
],
[
[
1585,
63,
966
],
[
966,
40,
1154
]
],
[
[
1585,
21,
29355
],
[
29355,
60,
1154
]
],
[
[
1585,
24,
688
],
[
688... | [
[
[
"Adenosine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Adenosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
"Octreotide"... | Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Adenosine (Compound) causes Injection site reaction (Side Effect) and Injection site reaction (Side Effect) is caused by Pasireotide (Compound)
Adenosine may ca... |
DB01050 | DB06779 | 848 | 365 | [
"DDInter900",
"DDInter470"
] | Ibuprofen | Dalteparin | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
848,
25,
365
]
],
[
[
848,
23,
297
],
[
297,
62,
365
]
],
[
[
848,
63,
954
],
[
954,
24,
365
]
],
[
[
848,
24,
1427
],
[
1427,
6... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Ibuprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ... | Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cause a m... |
DB00283 | DB00843 | 701 | 479 | [
"DDInter395",
"DDInter583"
] | Clemastine | Donepezil | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
701,
24,
479
]
],
[
[
701,
24,
843
],
[
843,
1,
479
]
],
[
[
701,
6,
12523
],
[
12523,
45,
479
]
],
[
[
701,
18,
10780
],
[
10780,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Clemastine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Ge... |
DB00959 | DB01089 | 1,486 | 1,340 | [
"DDInter1191",
"DDInter502"
] | Methylprednisolone | Deserpidine | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Moderate | 1 | [
[
[
1486,
24,
1340
]
],
[
[
1486,
63,
1245
],
[
1245,
40,
1340
]
],
[
[
1486,
24,
1411
],
[
1411,
63,
1340
]
],
[
[
1486,
40,
891
],
[
891... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpine"... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Reserpine and Reserpine (Compound) resembles Deserpidine (Compound)
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate inter... |
DB00818 | DB01142 | 898 | 1,264 | [
"DDInter1538",
"DDInter593"
] | Propofol | Doxepin | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
898,
24,
1264
]
],
[
[
898,
24,
401
],
[
401,
24,
1264
]
],
[
[
898,
6,
6017
],
[
6017,
45,
1264
]
],
[
[
898,
21,
28954
],
[
28954,
... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"... | Propofol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Propofol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound)
Propofol (Compound) caus... |
DB00405 | DB00747 | 128 | 1,442 | [
"DDInter517",
"DDInter1647"
] | Dexbrompheniramine | Scopolamine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
128,
24,
1442
]
],
[
[
128,
24,
19
],
[
19,
24,
1442
]
],
[
[
128,
63,
1089
],
[
1089,
24,
1442
]
],
[
[
128,
24,
551
],
[
551,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamin... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ip... |
DB01364 | DB01381 | 22 | 958 | [
"DDInter650",
"DDInter819"
] | Ephedrine | Ginkgo biloba | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
22,
24,
958
]
],
[
[
22,
74,
73
],
[
73,
24,
958
]
],
[
[
22,
64,
593
],
[
593,
24,
958
]
],
[
[
22,
63,
714
],
[
714,
24,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Ephedrine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken ... | Ephedrine (Compound) resembles Phentermine (Compound) and Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Ephedrine may lead to a major life threatening int... |
DB00564 | DB06603 | 1,236 | 39 | [
"DDInter293",
"DDInter1387"
] | Carbamazepine | Panobinostat | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1236,
25,
39
]
],
[
[
1236,
24,
112
],
[
112,
23,
39
]
],
[
[
1236,
63,
912
],
[
912,
24,
39
]
],
[
[
1236,
1,
282
],
[
282,
63,... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Interfero... |
DB00294 | DB01211 | 1,336 | 609 | [
"DDInter701",
"DDInter393"
] | Etonogestrel | Clarithromycin | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1336,
24,
609
]
],
[
[
1336,
6,
8374
],
[
8374,
45,
609
]
],
[
[
1336,
21,
28759
],
[
28759,
60,
609
]
],
[
[
1336,
63,
600
],
[
600,
... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Etonogestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Etonogestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Etonogestrel (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Clarithromycin (Compound)
Etonogestrel may cause a moderate interaction that could exacerb... |
DB00500 | DB00959 | 24 | 1,486 | [
"DDInter1831",
"DDInter1191"
] | Tolmetin | Methylprednisolone | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
24,
24,
1486
]
],
[
[
24,
24,
175
],
[
175,
40,
1486
]
],
[
[
24,
24,
167
],
[
167,
1,
1486
]
],
[
[
24,
63,
251
],
[
251,
1,
... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Meth... |
DB00059 | DB00879 | 1,560 | 1,279 | [
"DDInter1404",
"DDInter637"
] | Pegaspargase | Emtricitabine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse t... | Moderate | 1 | [
[
[
1560,
24,
1279
]
],
[
[
1560,
24,
322
],
[
322,
24,
1279
]
],
[
[
1560,
24,
384
],
[
384,
63,
1279
]
],
[
[
1560,
25,
1377
],
[
1377,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emtricitabine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and... |
DB00762 | DB04865 | 613 | 4 | [
"DDInter973",
"DDInter1335"
] | Irinotecan | Omacetaxine mepesuccinate | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
613,
24,
4
]
],
[
[
613,
7,
11089
],
[
11089,
46,
4
]
],
[
[
613,
18,
13042
],
[
13042,
46,
4
]
],
[
[
613,
18,
1917
],
[
1917,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Irinotecan",
"{u} (Compound) upregulates {v} (Gene)",
"DUSP8"
],
[
"DUSP8",
"{u} (Gene) is upregu... | Irinotecan (Compound) upregulates DUSP8 (Gene) and DUSP8 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Irinotecan (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Irinotecan (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is d... |
DB00245 | DB01105 | 357 | 222 | [
"DDInter181",
"DDInter1665"
] | Benzatropine | Sibutramine | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
357,
24,
222
]
],
[
[
357,
6,
2437
],
[
2437,
45,
222
]
],
[
[
357,
21,
28680
],
[
28680,
60,
222
]
],
[
[
357,
40,
847
],
[
847,
... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Benzatropine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
"{u} (Gene) is bound by {v} (Compou... | Benzatropine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Sibutramine (Compound)
Benzatropine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Sibutramine (Compound)
Benzatropine (Compound) resembles Atomoxetine (Compound) and Atomoxetine may cause a minor interaction that can li... |
DB01149 | DB01254 | 851 | 1,213 | [
"DDInter1274",
"DDInter484"
] | Nefazodone | Dasatinib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
851,
25,
1213
]
],
[
[
851,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
851,
7,
3218
],
[
3218,
46,
1213
]
],
[
[
851,
18,
4729
],
[
4729,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"... | Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Nefazodone (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is upregulated by Dasatinib (Compound)
Nefazodone (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dasatinib (Compound)
Nefazodone (C... |
DB00515 | DB00710 | 589 | 1,199 | [
"DDInter387",
"DDInter897"
] | Cisplatin | Ibandronate | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Moderate | 1 | [
[
[
589,
24,
1199
]
],
[
[
589,
63,
963
],
[
963,
1,
1199
]
],
[
[
589,
21,
28719
],
[
28719,
60,
1199
]
],
[
[
589,
24,
1555
],
[
1555,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibandronate"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zoledronic acid"
],
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid and Zoledronic acid (Compound) resembles Ibandronate (Compound)
Cisplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ibandronate (Compound)
Cisplatin may cause a moderate interaction t... |
DB00731 | DB01118 | 1,144 | 33 | [
"DDInter1269",
"DDInter76"
] | Nateglinide | Amiodarone | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
1144,
24,
33
]
],
[
[
1144,
6,
6799
],
[
6799,
45,
33
]
],
[
[
1144,
21,
28681
],
[
28681,
60,
33
]
],
[
[
1144,
63,
1152
],
[
1152,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Nateglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compound)... | Nateglinide (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Amiodarone (Compound)
Nateglinide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Amiodarone (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Li... |
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