drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01611 | DB11796 | 1,487 | 1,612 | [
"DDInter893",
"DDInter786"
] | Hydroxychloroquine | Fostemsavir | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Major | 2 | [
[
[
1487,
25,
1612
]
],
[
[
1487,
63,
112
],
[
112,
23,
1612
]
],
[
[
1487,
64,
1424
],
[
1424,
24,
1612
]
],
[
[
1487,
25,
823
],
[
823,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Hydroxychloroquine may lead to a major life threatening interaction when taken with Quinine and Qui... |
DB00851 | DB06674 | 611 | 908 | [
"DDInter463",
"DDInter837"
] | Dacarbazine | Golimumab | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
611,
25,
908
]
],
[
[
611,
63,
1461
],
[
1461,
23,
908
]
],
[
[
611,
24,
200
],
[
200,
63,
908
]
],
[
[
611,
24,
1136
],
[
1136,
... | [
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Can... |
DB00719 | DB01242 | 1,219 | 1,237 | [
"DDInter149",
"DDInter410"
] | Azatadine | Clomipramine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1219,
24,
1237
]
],
[
[
1219,
63,
684
],
[
684,
1,
1237
]
],
[
[
1219,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
1219,
63,
902
],
[
902,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (... |
DB00738 | DB01015 | 485 | 1,247 | [
"DDInter1420",
"DDInter1724"
] | Pentamidine | Sulfamethoxazole | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Minor | 0 | [
[
[
485,
23,
1247
]
],
[
[
485,
6,
3486
],
[
3486,
45,
1247
]
],
[
[
485,
7,
9900
],
[
9900,
46,
1247
]
],
[
[
485,
21,
28709
],
[
28709,
... | [
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compo... | Pentamidine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfamethoxazole (Compound)
Pentamidine (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is upregulated by Sulfamethoxazole (Compound)
Pentamidine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is cau... |
DB01110 | DB01232 | 86 | 1,327 | [
"DDInter1209",
"DDInter1640"
] | Miconazole | Saquinavir | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
86,
24,
1327
]
],
[
[
86,
63,
798
],
[
798,
40,
1327
]
],
[
[
86,
6,
10215
],
[
10215,
45,
1327
]
],
[
[
86,
7,
5415
],
[
5415,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Miconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Saquinavir (Compound)
Miconazole (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene... |
DB00285 | DB03904 | 1,100 | 1,574 | [
"DDInter1927",
"DDInter1903"
] | Venlafaxine | Urea | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Moderate | 1 | [
[
[
1100,
24,
1574
]
],
[
[
1100,
1,
643
],
[
643,
63,
1574
]
],
[
[
1100,
63,
1314
],
[
1314,
24,
1574
]
],
[
[
1100,
24,
657
],
[
657,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Urea"
]
],
[
[
"Venlafaxine",
"{u} (Compound) resembles {v} (Compound)",
"Desvenlafaxine"
],
[
"Desvenlafaxine",
"{u} may cause a mod... | Venlafaxine (Compound) resembles Desvenlafaxine (Compound) and Des
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Urea
Venlafaxine may cause a moderate interaction t... |
DB01072 | DB11827 | 915 | 433 | [
"DDInter129",
"DDInter669"
] | Atazanavir | Ertugliflozin | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
915,
24,
433
]
],
[
[
915,
63,
959
],
[
959,
24,
433
]
],
[
[
915,
24,
1142
],
[
1142,
24,
433
]
],
[
[
915,
64,
175
],
[
175,
2... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlista... |
DB00446 | DB08917 | 597 | 1,608 | [
"DDInter351",
"DDInter723"
] | Chloramphenicol | Ferric carboxymaltose | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013. | Moderate | 1 | [
[
[
597,
24,
1608
]
],
[
[
597,
24,
428
],
[
428,
63,
1608
]
],
[
[
597,
24,
1596
],
[
1596,
24,
1608
]
],
[
[
597,
24,
428
],
[
428,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferric carboxymaltose"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrou... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ferric carboxymaltose
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when... |
DB00889 | DB01259 | 1,133 | 392 | [
"DDInter840",
"DDInter1024"
] | Granisetron | Lapatinib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1133,
24,
392
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1133,
18,
10375
],
[
10375,
57,
392
]
],
[
[
1133,
21,
28688
],
[
286... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Granisetron (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Lapatinib (Compound)
Granisetron (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
... |
DB00563 | DB00945 | 663 | 1,479 | [
"DDInter1174",
"DDInter20"
] | Methotrexate | Acetylsalicylic acid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Major | 2 | [
[
[
663,
25,
1479
]
],
[
[
663,
63,
316
],
[
316,
40,
1479
]
],
[
[
663,
25,
1338
],
[
1338,
24,
1479
]
],
[
[
663,
7,
2900
],
[
2900,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitazoxanide"
],
[
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Nitazoxanide and Nitazoxanide (Compound) resembles Acetylsalicylic acid (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate inter... |
DB00245 | DB00747 | 357 | 1,442 | [
"DDInter181",
"DDInter1647"
] | Benzatropine | Scopolamine | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
357,
24,
1442
]
],
[
[
357,
35,
19
],
[
19,
24,
1442
]
],
[
[
357,
24,
1089
],
[
1089,
24,
1442
]
],
[
[
357,
6,
4304
],
[
4304,
... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Benzatropine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when ta... | Benzatropine (Compound) resembles Hyoscyamine (Compound) and Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Benzatropine may cause a moderate interaction ... |
DB00204 | DB01249 | 228 | 258 | [
"DDInter580",
"DDInter958"
] | Dofetilide | Iodixanol | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
228,
24,
258
]
],
[
[
228,
24,
497
],
[
497,
1,
258
]
],
[
[
228,
21,
28844
],
[
28844,
60,
258
]
],
[
[
228,
25,
485
],
[
485,
... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
],
[
... | Dofetilide may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Dofetilide (Compound) causes Ventricular arrhythmia (Side Effect) and Ventricular arrhythmia (Side Effect) is caused by Iodixanol (Compound)
Dofetilide may lead to a m... |
DB01024 | DB06688 | 1,096 | 1,430 | [
"DDInter1252",
"DDInter1677"
] | Mycophenolic acid | Sipuleucel-T | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1096,
24,
1430
]
],
[
[
1096,
25,
676
],
[
676,
63,
1430
]
],
[
[
1096,
24,
1531
],
[
1531,
24,
1430
]
],
[
[
1096,
24,
713
],
[
713,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[... | Mycophenolic acid may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and ... |
DB00402 | DB12500 | 1,407 | 283 | [
"DDInter685",
"DDInter714"
] | Eszopiclone | Fedratinib | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1407,
24,
283
]
],
[
[
1407,
24,
351
],
[
351,
23,
283
]
],
[
[
1407,
24,
1419
],
[
1419,
24,
283
]
],
[
[
1407,
63,
600
],
[
600,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib... |
DB00163 | DB00563 | 1,461 | 663 | [
"DDInter1943",
"DDInter1174"
] | Vitamin E | Methotrexate | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1461,
24,
663
]
],
[
[
1461,
18,
15501
],
[
15501,
57,
663
]
],
[
[
1461,
24,
328
],
[
328,
62,
663
]
],
[
[
1461,
23,
891
],
[
891,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Vitamin E",
"{u} (Compound) downregulates {v} (Gene)",
"CCDC86"
],
[
"CCDC86",
"{u} (Gene) is downregulated by ... | Vitamin E (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Methotrexate (Compound)
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Methotr... |
DB00425 | DB01142 | 558 | 1,264 | [
"DDInter1970",
"DDInter593"
] | Zolpidem | Doxepin | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
558,
24,
1264
]
],
[
[
558,
24,
401
],
[
401,
24,
1264
]
],
[
[
558,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
558,
24,
649
],
[
649,
... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"... | Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamin... |
DB00679 | DB01064 | 684 | 1,148 | [
"DDInter1796",
"DDInter987"
] | Thioridazine | Isoprenaline | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
684,
25,
1148
]
],
[
[
684,
24,
480
],
[
480,
24,
1148
]
],
[
[
684,
63,
874
],
[
874,
24,
1148
]
],
[
[
684,
7,
3576
],
[
3576,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Form... | Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and... |
DB01136 | DB01229 | 772 | 973 | [
"DDInter305",
"DDInter1378"
] | Carvedilol | Paclitaxel (protein-bound) | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
772,
24,
973
]
],
[
[
772,
6,
8374
],
[
8374,
45,
973
]
],
[
[
772,
18,
2183
],
[
2183,
46,
973
]
],
[
[
772,
21,
29267
],
[
29267,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Carvedilol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Carvedilol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Carvedilol (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by Paclitaxel (Compound)
Carvedilol (Compou... |
DB04868 | DB06688 | 478 | 1,430 | [
"DDInter1293",
"DDInter1677"
] | Nilotinib | Sipuleucel-T | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
478,
24,
1430
]
],
[
[
478,
63,
175
],
[
175,
24,
1430
]
],
[
[
478,
64,
51
],
[
51,
24,
1430
]
],
[
[
478,
25,
676
],
[
676,
63... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Nilotinib may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin ... |
DB01394 | DB12015 | 1,554 | 1,033 | [
"DDInter431",
"DDInter53"
] | Colchicine | Alpelisib | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1554,
24,
1033
]
],
[
[
1554,
24,
951
],
[
951,
24,
1033
]
],
[
[
1554,
63,
10
],
[
10,
24,
1033
]
],
[
[
1554,
25,
760
],
[
760,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone ... |
DB00899 | DB00986 | 411 | 1,192 | [
"DDInter1579",
"DDInter834"
] | Remifentanil | Glycopyrronium | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
411,
24,
1192
]
],
[
[
411,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
411,
63,
262
],
[
262,
24,
1192
]
],
[
[
411,
21,
29231
],
[
29231,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],... | Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Clidinium a... |
DB00647 | DB12332 | 675 | 1,619 | [
"DDInter528",
"DDInter1626"
] | Dextropropoxyphene | Rucaparib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
675,
24,
1619
]
],
[
[
675,
25,
222
],
[
222,
23,
1619
]
],
[
[
675,
40,
307
],
[
307,
23,
1619
]
],
[
[
675,
23,
112
],
[
112,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
... | Dextropropoxyphene may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Dextropropoxyphene (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit ... |
DB06186 | DB08889 | 1,439 | 350 | [
"DDInter969",
"DDInter299"
] | Ipilimumab | Carfilzomib | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
1439,
24,
350
]
],
[
[
1439,
24,
1060
],
[
1060,
63,
350
]
],
[
[
1439,
63,
482
],
[
482,
24,
350
]
],
[
[
1439,
24,
310
],
[
310,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
],... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Tiog... |
DB00987 | DB01005 | 1,224 | 995 | [
"DDInter460",
"DDInter894"
] | Cytarabine | Hydroxyurea | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
1224,
24,
995
]
],
[
[
1224,
5,
11555
],
[
11555,
44,
995
]
],
[
[
1224,
62,
1299
],
[
1299,
23,
995
]
],
[
[
1224,
23,
945
],
[
945,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Cytarabine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disea... | Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Hydroxyurea (Compound)
Cytarabine may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical effects when take... |
DB01100 | DB12130 | 1,568 | 1,017 | [
"DDInter1470",
"DDInter1094"
] | Pimozide | Lorlatinib | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1568,
24,
1017
]
],
[
[
1568,
25,
1491
],
[
1491,
24,
1017
]
],
[
[
1568,
64,
888
],
[
888,
24,
1017
]
],
[
[
1568,
63,
629
],
[
629,
... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
],
[
"Midostaurin",... | Pimozide may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Pimozide may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interact... |
DB00762 | DB09074 | 613 | 1,362 | [
"DDInter973",
"DDInter1327"
] | Irinotecan | Olaparib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
613,
24,
1362
]
],
[
[
613,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
613,
63,
139
],
[
139,
24,
1362
]
],
[
[
613,
24,
1619
],
[
1619,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovu... |
DB01098 | DB11989 | 14 | 1,434 | [
"DDInter1622",
"DDInter183"
] | Rosuvastatin | Benznidazole | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
14,
24,
1434
]
],
[
[
14,
35,
788
],
[
788,
24,
1434
]
],
[
[
14,
24,
375
],
[
375,
24,
1434
]
],
[
[
14,
24,
148
],
[
148,
63,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Rosuvastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when t... | Rosuvastatin (Compound) resembles Pitavastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Rosuvastatin may cause a moderate interact... |
DB00857 | DB11915 | 1,387 | 1,293 | [
"DDInter1768",
"DDInter1909"
] | Terbinafine | Valbenazine | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Major | 2 | [
[
[
1387,
25,
1293
]
],
[
[
1387,
24,
401
],
[
401,
24,
1293
]
],
[
[
1387,
64,
506
],
[
506,
24,
1293
]
],
[
[
1387,
24,
159
],
[
159,
... | [
[
[
"Terbinafine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valbenazine"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Prome... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Terbinafine may lead to a major life threatening interaction when taken with Dextromethorphan and Dextrome... |
DB00712 | DB13620 | 1,274 | 948 | [
"DDInter763",
"DDInter1499"
] | Flurbiprofen | Potassium gluconate | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Moderate | 1 | [
[
[
1274,
24,
948
]
],
[
[
1274,
35,
848
],
[
848,
24,
948
]
],
[
[
1274,
63,
1027
],
[
1027,
24,
948
]
],
[
[
1274,
24,
1171
],
[
1171,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases... | Flurbiprofen (Compound) resembles Ibuprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Flurbiprofen may cause a moderate interactio... |
DB01176 | DB06282 | 537 | 516 | [
"DDInter453",
"DDInter1053"
] | Cyclizine | Levocetirizine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
537,
24,
516
]
],
[
[
537,
63,
701
],
[
701,
24,
516
]
],
[
[
537,
24,
1293
],
[
1293,
63,
516
]
],
[
[
537,
24,
651
],
[
651,
2... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine and Val... |
DB00030 | DB01197 | 1,685 | 1,603 | [
"DDInter934",
"DDInter292"
] | Insulin human | Captopril | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1685,
24,
1603
]
],
[
[
1685,
24,
610
],
[
610,
1,
1603
]
],
[
[
1685,
24,
1019
],
[
1019,
63,
1603
]
],
[
[
1685,
24,
959
],
[
959,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that ... |
DB01069 | DB01100 | 401 | 1,568 | [
"DDInter1533",
"DDInter1470"
] | Promethazine | Pimozide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
401,
25,
1568
]
],
[
[
401,
64,
78
],
[
78,
40,
1568
]
],
[
[
401,
63,
1557
],
[
1557,
25,
1568
]
],
[
[
401,
6,
1977
],
[
1977,
... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u}... | Promethazine may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may lead to a major life threatening interaction when ta... |
DB08899 | DB11978 | 129 | 124 | [
"DDInter649",
"DDInter822"
] | Enzalutamide | Glasdegib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
129,
25,
124
]
],
[
[
129,
25,
1135
],
[
1135,
23,
124
]
],
[
[
129,
62,
1247
],
[
1247,
23,
124
]
],
[
[
129,
25,
466
],
[
466,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ... | Enzalutamide may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole m... |
DB00016 | DB00881 | 787 | 954 | [
"DDInter671",
"DDInter1554"
] | Erythropoietin | Quinapril | Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow [FDA Label]. Epoetin alfa (Epoge) was developed by Amgen Inc. in 1983 as the first rhEPO commerc... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Minor | 0 | [
[
[
787,
23,
954
]
],
[
[
787,
23,
1638
],
[
1638,
1,
954
]
],
[
[
787,
23,
1638
],
[
1638,
1,
610
],
[
610,
1,
954
]
],
[
[
787,
23... | [
[
[
"Erythropoietin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quinapril"
]
],
[
[
"Erythropoietin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trandolapril"
],
... | Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Trandolapril and Trandolapril (Compound) resembles Enalapril (... |
DB00647 | DB09291 | 675 | 741 | [
"DDInter528",
"DDInter1615"
] | Dextropropoxyphene | Rolapitant | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
675,
24,
741
]
],
[
[
675,
63,
506
],
[
506,
24,
741
]
],
[
[
675,
40,
1164
],
[
1164,
24,
741
]
],
[
[
675,
25,
1264
],
[
1264,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextrometho... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Dextropropoxyphene (Compound) resembles Trimipramine (Compound) and Trimipramine may cause a... |
DB00092 | DB11767 | 58 | 1,583 | [
"DDInter40",
"DDInter1643"
] | Alefacept | Sarilumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
58,
24,
1583
]
],
[
[
58,
23,
1461
],
[
1461,
23,
1583
]
],
[
[
58,
24,
362
],
[
362,
24,
1583
]
],
[
[
58,
24,
287
],
[
287,
63... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"V... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may ca... |
DB00341 | DB00708 | 1,242 | 1,454 | [
"DDInter343",
"DDInter1718"
] | Cetirizine | Sufentanil | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
1242,
24,
1454
]
],
[
[
1242,
40,
11366
],
[
11366,
40,
1454
]
],
[
[
1242,
24,
704
],
[
704,
40,
1454
]
],
[
[
1242,
21,
28658
],
[
2... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Cetirizine",
"{u} (Compound) resembles {v} (Compound)",
"Anileridine"
],
[
"Anileridine",
"{u} (Compound) resemb... | Cetirizine (Compound) resembles Anileridine (Compound) and Anileridine (Compound) resembles Sufentanil (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Cetirizine (Compound) causes Vomiting (Side Effect... |
DB00938 | DB14568 | 455 | 982 | [
"DDInter1635",
"DDInter1000"
] | Salmeterol | Ivosidenib | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
455,
24,
982
]
],
[
[
455,
24,
1032
],
[
1032,
24,
982
]
],
[
[
455,
63,
1559
],
[
1559,
24,
982
]
],
[
[
455,
24,
159
],
[
159,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
],
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Famotidine an... |
DB00316 | DB08870 | 474 | 850 | [
"DDInter14",
"DDInter228"
] | Acetaminophen | Brentuximab vedotin | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
474,
24,
850
]
],
[
[
474,
24,
267
],
[
267,
24,
850
]
],
[
[
474,
63,
305
],
[
305,
24,
850
]
],
[
[
474,
24,
1017
],
[
1017,
6... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Aspara... |
DB06788 | DB08864 | 1,616 | 786 | [
"DDInter864",
"DDInter1595"
] | Histrelin | Rilpivirine | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
1616,
24,
786
]
],
[
[
1616,
62,
112
],
[
112,
23,
786
]
],
[
[
1616,
63,
594
],
[
594,
24,
786
]
],
[
[
1616,
24,
823
],
[
823,
... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Histrelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Histrelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rilpivirine
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosuti... |
DB06723 | DB11613 | 115 | 1,519 | [
"DDInter58",
"DDInter1924"
] | Aluminum hydroxide | Velpatasvir | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
115,
24,
1519
]
],
[
[
115,
63,
594
],
[
594,
24,
1519
]
],
[
[
115,
62,
1559
],
[
1559,
24,
1519
]
],
[
[
115,
25,
1475
],
[
1475,
... | [
[
[
"Aluminum hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Velpatasvir"
]
],
[
[
"Aluminum hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"... | Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Velpatasvir
Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Famotidi... |
DB08890 | DB11113 | 16 | 657 | [
"DDInter1069",
"DDInter307"
] | Linaclotide | Castor oil | Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin deri... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Minor | 0 | [
[
[
16,
23,
657
]
],
[
[
16,
62,
355
],
[
355,
24,
657
]
],
[
[
16,
1,
11396
],
[
11396,
40,
1154
],
[
1154,
24,
657
]
],
[
[
16,
62... | [
[
[
"Linaclotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Castor oil"
]
],
[
[
"Linaclotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lactulose"
],
[
... | Linaclotide may cause a minor interaction that can limit clinical effects when taken with Lactulose and Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Linaclotide (Compound) resembles Terlipressin (Compound) and Terlipressin (Compound) resembles Pasireotide (Compoun... |
DB00812 | DB06589 | 998 | 1,250 | [
"DDInter1451",
"DDInter1400"
] | Phenylbutazone | Pazopanib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
998,
24,
1250
]
],
[
[
998,
6,
8374
],
[
8374,
45,
1250
]
],
[
[
998,
40,
307
],
[
307,
23,
1250
]
],
[
[
998,
24,
1135
],
[
1135,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound)
Phenylbutazone (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Phenylbutazone may cause a moderate interaction that could exace... |
DB00476 | DB11963 | 109 | 1,045 | [
"DDInter608",
"DDInter465"
] | Duloxetine | Dacomitinib | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
109,
24,
1045
]
],
[
[
109,
25,
1039
],
[
1039,
24,
1045
]
],
[
[
109,
24,
1376
],
[
1376,
24,
1045
]
],
[
[
109,
23,
1194
],
[
1194,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Duloxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"Dexf... | Duloxetine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphe... |
DB04932 | DB06605 | 1,564 | 1,409 | [
"DDInter491",
"DDInter108"
] | Defibrotide | Apixaban | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1564,
25,
1409
]
],
[
[
1564,
23,
539
],
[
539,
62,
1409
]
],
[
[
1564,
63,
109
],
[
109,
24,
1409
]
],
[
[
1564,
24,
41
],
[
41,
... | [
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Defibrotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Defibrotide may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Apixaban
Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may... |
DB00188 | DB00261 | 168 | 702 | [
"DDInter222",
"DDInter93"
] | Bortezomib | Anagrelide | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Moderate | 1 | [
[
[
168,
24,
702
]
],
[
[
168,
5,
11555
],
[
11555,
44,
702
]
],
[
[
168,
6,
7950
],
[
7950,
45,
702
]
],
[
[
168,
18,
7212
],
[
7212,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anagrelide"
]
],
[
[
"Bortezomib",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Diseas... | Bortezomib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Anagrelide (Compound)
Bortezomib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Anagrelide (Compound)
Bortezomib (Compound) downregulates HMG20B (Gene) and HMG20B (Gene) is upregulated by Anagrelide (C... |
DB08918 | DB11095 | 41 | 235 | [
"DDInter1059",
"DDInter505"
] | Levomilnacipran | Desirudin | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
41,
24,
235
]
],
[
[
41,
1,
901
],
[
901,
24,
235
]
],
[
[
41,
63,
578
],
[
578,
24,
235
]
],
[
[
41,
64,
121
],
[
121,
24,
... | [
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Levomilnacipran",
"{u} (Compound) resembles {v} (Compound)",
"Milnacipran"
],
[
"Milnacipran",
"{u} may caus... | Levomilnacipran (Compound) resembles Milnacipran (Compound) and Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction... |
DB00384 | DB01069 | 1,275 | 401 | [
"DDInter1859",
"DDInter1533"
] | Triamterene | Promethazine | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1275,
24,
401
]
],
[
[
1275,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1275,
24,
104
],
[
104,
24,
401
]
],
[
[
1275,
21,
28787
],
[
28787,... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdi... |
DB00673 | DB01319 | 723 | 34 | [
"DDInter112",
"DDInter777"
] | Aprepitant | Fosamprenavir | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
723,
24,
34
]
],
[
[
723,
24,
1091
],
[
1091,
40,
34
]
],
[
[
723,
6,
8374
],
[
8374,
45,
34
]
],
[
[
723,
21,
29062
],
[
29062,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Aprepitant (Compound) causes Neutropenia (Side Effect) and N... |
DB01159 | DB01611 | 419 | 1,487 | [
"DDInter854",
"DDInter893"
] | Halothane | Hydroxychloroquine | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
419,
25,
1487
]
],
[
[
419,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
419,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
419,
63,
521
],
[
521,
... | [
[
[
"Halothane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"Prim... | Halothane may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Halothane (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Halothane may cause... |
DB01095 | DB01098 | 671 | 14 | [
"DDInter769",
"DDInter1622"
] | Fluvastatin | Rosuvastatin | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
671,
24,
14
]
],
[
[
671,
6,
8374
],
[
8374,
45,
14
]
],
[
[
671,
34,
8559
],
[
8559,
45,
14
]
],
[
[
671,
7,
11048
],
[
11048,
... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Fluvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Fluvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rosuvastatin (Compound)
Fluvastatin (Compound) binds HMGCR (Gene) and Fluvastatin (Compound) upregulates HMGCR (Gene) and HMGCR (Gene) is bound by Rosuvastatin (Compound)
Fluvastatin (Compound) upregulates VAT1 (Gene) and VAT1 (Gene) is upregulate... |
DB00687 | DB01100 | 870 | 1,568 | [
"DDInter747",
"DDInter1470"
] | Fludrocortisone | Pimozide | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
870,
25,
1568
]
],
[
[
870,
64,
78
],
[
78,
40,
1568
]
],
[
[
870,
21,
29024
],
[
29024,
60,
1568
]
],
[
[
870,
23,
455
],
[
455,
... | [
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
... | Fludrocortisone may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Fludrocortisone (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pimozide (Compound)
Fludrocortisone may cause a minor interaction t... |
DB00317 | DB11652 | 883 | 1,155 | [
"DDInter810",
"DDInter1891"
] | Gefitinib | Tucatinib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
883,
24,
1155
]
],
[
[
883,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
883,
24,
609
],
[
609,
24,
1155
]
],
[
[
883,
40,
26
],
[
26,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarith... |
DB00197 | DB00813 | 1,324 | 704 | [
"DDInter1881",
"DDInter722"
] | Troglitazone | Fentanyl | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Moderate | 1 | [
[
[
1324,
24,
704
]
],
[
[
1324,
24,
307
],
[
307,
1,
704
]
],
[
[
1324,
24,
194
],
[
194,
40,
704
]
],
[
[
1324,
24,
1476
],
[
1476,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Fentanyl (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Fentanyl (Compound)
... |
DB00031 | DB00569 | 20 | 553 | [
"DDInter1764",
"DDInter775"
] | Tenecteplase | Fondaparinux | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Major | 2 | [
[
[
20,
25,
553
]
],
[
[
20,
23,
539
],
[
539,
62,
553
]
],
[
[
20,
24,
972
],
[
972,
63,
553
]
],
[
[
20,
24,
1416
],
[
1416,
24,
... | [
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
]
],
[
[
"Tenecteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum... | Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Fondaparinux
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate and ... |
DB00686 | DB00758 | 383 | 1,347 | [
"DDInter1424",
"DDInter413"
] | Pentosan polysulfate | Clopidogrel | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
383,
24,
1347
]
],
[
[
383,
63,
1018
],
[
1018,
25,
1347
]
],
[
[
383,
21,
29215
],
[
29215,
60,
1347
]
],
[
[
383,
24,
578
],
[
578,
... | [
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Pentosan polysulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlop... | Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Pentosan polysulfate (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Clopidog... |
DB06697 | DB09098 | 436 | 98 | [
"DDInter121",
"DDInter1700"
] | Artemether | Somatrem | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
436,
24,
98
]
],
[
[
436,
24,
159
],
[
159,
63,
98
]
],
[
[
436,
64,
609
],
[
609,
24,
98
]
],
[
[
436,
63,
690
],
[
690,
24,
... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Artemether may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Artemether may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromyci... |
DB00242 | DB00552 | 1,064 | 1,238 | [
"DDInter392",
"DDInter1425"
] | Cladribine | Pentostatin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Major | 2 | [
[
[
1064,
36,
1238
]
],
[
[
1064,
36,
1083
],
[
1083,
40,
1238
]
],
[
[
1064,
1,
903
],
[
903,
40,
1238
]
],
[
[
1064,
25,
1426
],
[
1426,... | [
[
[
"Cladribine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Pentostatin"
]
],
[
[
"Cladribine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interacti... | Cladribine (Compound) resembles Pentostatin (Compound) and
Cladribine (Compound) resembles Trifluridine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine (Compound) resembles Pentostatin (Compound)
Cladribine (Compound) resembles Decitabine (Compoun... |
DB01168 | DB06643 | 1,053 | 1,136 | [
"DDInter1526",
"DDInter500"
] | Procarbazine | Denosumab | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
1053,
24,
1136
]
],
[
[
1053,
63,
1648
],
[
1648,
24,
1136
]
],
[
[
1053,
64,
1377
],
[
1377,
24,
1136
]
],
[
[
1053,
25,
1510
],
[
15... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Procarbazine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may... |
DB00013 | DB01197 | 1,255 | 1,603 | [
"DDInter1905",
"DDInter292"
] | Urokinase | Captopril | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1255,
24,
1603
]
],
[
[
1255,
24,
610
],
[
610,
1,
1603
]
],
[
[
1255,
24,
1061
],
[
1061,
24,
1603
]
],
[
[
1255,
25,
365
],
[
365,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could ... |
DB00635 | DB00681 | 1,573 | 1,287 | [
"DDInter1515",
"DDInter85"
] | Prednisone | Amphotericin B | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Moderate | 1 | [
[
[
1573,
24,
1287
]
],
[
[
1573,
21,
29876
],
[
29876,
60,
1287
]
],
[
[
1573,
63,
1622
],
[
1622,
23,
1287
]
],
[
[
1573,
63,
663
],
[
6... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
]
],
[
[
"Prednisone",
"{u} (Compound) causes {v} (Side Effect)",
"Epilepsy"
],
[
"Epilepsy",
"{u} (Side Effect) is ca... | Prednisone (Compound) causes Epilepsy (Side Effect) and Epilepsy (Side Effect) is caused by Amphotericin B (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Amp... |
DB00436 | DB00581 | 323 | 355 | [
"DDInter179",
"DDInter1018"
] | Bendroflumethiazide | Lactulose | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
323,
24,
355
]
],
[
[
323,
63,
1647
],
[
1647,
1,
355
]
],
[
[
323,
21,
28722
],
[
28722,
60,
355
]
],
[
[
323,
24,
286
],
[
286,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Lactulose (Compound)
Bendroflumethiazide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lactulose (Compound)
Bendroflumethiazide may cause a modera... |
DB00991 | DB11817 | 97 | 1,259 | [
"DDInter1358",
"DDInter165"
] | Oxaprozin | Baricitinib | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
97,
24,
1259
]
],
[
[
97,
63,
1274
],
[
1274,
24,
1259
]
],
[
[
97,
40,
576
],
[
576,
24,
1259
]
],
[
[
97,
24,
848
],
[
848,
24... | [
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Oxaprozin (Compound) resembles Methadone (Compound) and Methadone may cause a moderate interaction that coul... |
DB00862 | DB01259 | 1,005 | 392 | [
"DDInter1918",
"DDInter1024"
] | Vardenafil | Lapatinib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1005,
24,
392
]
],
[
[
1005,
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],
[
8374,
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[
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29429
],
[
29429,
60,
392
]
],
[
[
1005,
24,
112
],
[
112,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Vardenafil (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronida... |
DB00033 | DB01156 | 342 | 593 | [
"DDInter949",
"DDInter252"
] | Interferon gamma-1b | Bupropion | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
342,
25,
593
]
],
[
[
342,
24,
126
],
[
126,
24,
593
]
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[
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342,
24,
1383
],
[
1383,
63,
593
]
],
[
[
342,
63,
305
],
[
305,
2... | [
[
[
"Interferon gamma-1b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Bupropion
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Sodium s... |
DB01001 | DB01105 | 688 | 222 | [
"DDInter1632",
"DDInter1665"
] | Salbutamol | Sibutramine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
688,
24,
222
]
],
[
[
688,
6,
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[
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45,
222
]
],
[
[
688,
21,
28698
],
[
28698,
60,
222
]
],
[
[
688,
63,
839
],
[
839,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Salbutamol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Salbutamol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and G... |
DB01319 | DB11828 | 34 | 1,406 | [
"DDInter777",
"DDInter1281"
] | Fosamprenavir | Neratinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
34,
25,
1406
]
],
[
[
34,
25,
1135
],
[
1135,
23,
1406
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[
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34,
64,
392
],
[
392,
24,
1406
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[
[
34,
63,
1195
],
[
1195,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u... | Fosamprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Fosamprenavir may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate inter... |
DB01501 | DB11186 | 1,118 | 1,609 | [
"DDInter549",
"DDInter1427"
] | Difenoxin | Pentoxyverine | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1118,
24,
1609
]
],
[
[
1118,
63,
556
],
[
556,
24,
1609
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],
[
[
1118,
24,
1580
],
[
1580,
24,
1609
]
],
[
[
1118,
24,
733
],
[
733,
... | [
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valproic acid"
],
... | Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol an... |
DB00983 | DB13074 | 480 | 877 | [
"DDInter776",
"DDInter1110"
] | Formoterol | Macimorelin | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
480,
25,
877
]
],
[
[
480,
24,
673
],
[
673,
24,
877
]
],
[
[
480,
63,
176
],
[
176,
24,
877
]
],
[
[
480,
23,
1042
],
[
1042,
2... | [
[
[
"Formoterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
],
[
"Aripipr... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine... |
DB01132 | DB01319 | 1,130 | 34 | [
"DDInter1472",
"DDInter777"
] | Pioglitazone | Fosamprenavir | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
1130,
24,
34
]
],
[
[
1130,
63,
1091
],
[
1091,
40,
34
]
],
[
[
1130,
6,
8374
],
[
8374,
45,
34
]
],
[
[
1130,
21,
28723
],
[
28723,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Pioglitazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Pioglitazone (Compound) causes Malnutrition (Side Effect... |
DB00358 | DB01165 | 1,010 | 1,539 | [
"DDInter1140",
"DDInter1325"
] | Mefloquine | Ofloxacin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
1010,
24,
1539
]
],
[
[
1010,
64,
1176
],
[
1176,
1,
1539
]
],
[
[
1010,
25,
945
],
[
945,
40,
1539
]
],
[
[
1010,
24,
956
],
[
956,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxa... | Mefloquine may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Mefloquine may cause a m... |
DB00501 | DB01592 | 752 | 1,596 | [
"DDInter380",
"DDInter975"
] | Cimetidine | Iron | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Minor | 0 | [
[
[
752,
23,
1596
]
],
[
[
752,
21,
29134
],
[
29134,
60,
1596
]
],
[
[
752,
23,
1384
],
[
1384,
63,
1596
]
],
[
[
752,
23,
1117
],
[
1117... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Iron"
]
],
[
[
"Cimetidine",
"{u} (Compound) causes {v} (Side Effect)",
"Flatulence"
],
[
"Flatulence",
"{u} (Side Effect) is caused by ... | Cimetidine (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Iron (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Iron
Cimetidi... |
DB00792 | DB00964 | 832 | 1,617 | [
"DDInter1878",
"DDInter110"
] | Tripelennamine | Apraclonidine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Moderate | 1 | [
[
[
832,
24,
1617
]
],
[
[
832,
63,
1020
],
[
1020,
1,
1617
]
],
[
[
832,
24,
1084
],
[
1084,
40,
1617
]
],
[
[
832,
63,
876
],
[
876,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Apraclonidine (Compound)
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine (Compound) resembles Apraclonidine... |
DB04575 | DB09038 | 35 | 1,450 | [
"DDInter1555",
"DDInter636"
] | Quinestrol | Empagliflozin | The 3-cyclopentyl ether of ethinyl estradiol. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
35,
24,
1450
]
],
[
[
35,
63,
1486
],
[
1486,
24,
1450
]
],
[
[
35,
24,
1017
],
[
1017,
63,
1450
]
],
[
[
35,
24,
129
],
[
129,
... | [
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
... | Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Lo... |
DB06589 | DB11915 | 1,250 | 1,293 | [
"DDInter1400",
"DDInter1909"
] | Pazopanib | Valbenazine | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1250,
24,
1293
]
],
[
[
1250,
62,
112
],
[
112,
23,
1293
]
],
[
[
1250,
24,
710
],
[
710,
63,
1293
]
],
[
[
1250,
63,
521
],
[
521,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Bini... |
DB00835 | DB00850 | 100 | 1,630 | [
"DDInter245",
"DDInter1432"
] | Brompheniramine | Perphenazine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
100,
24,
1630
]
],
[
[
100,
63,
252
],
[
252,
40,
1630
]
],
[
[
100,
63,
1242
],
[
1242,
24,
1630
]
],
[
[
100,
24,
673
],
[
673,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interact... |
DB00015 | DB00176 | 582 | 529 | [
"DDInter1585",
"DDInter770"
] | Reteplase | Fluvoxamine | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Moderate | 1 | [
[
[
582,
24,
529
]
],
[
[
582,
24,
1274
],
[
1274,
63,
529
]
],
[
[
582,
25,
1172
],
[
1172,
24,
529
]
],
[
[
582,
25,
1421
],
[
1421,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvoxamine"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine
Reteplase may lead to a major life threatening interaction when taken with Ibritumomab tiuxetan and Ibritumo... |
DB00069 | DB00951 | 367 | 1,072 | [
"DDInter946",
"DDInter986"
] | Interferon alfacon-1 | Isoniazid | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
367,
24,
1072
]
],
[
[
367,
24,
1031
],
[
1031,
24,
1072
]
],
[
[
367,
63,
912
],
[
912,
24,
1072
]
],
[
[
367,
24,
309
],
[
309,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophyl... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00862 | DB01128 | 1,005 | 918 | [
"DDInter1918",
"DDInter204"
] | Vardenafil | Bicalutamide | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1005,
24,
918
]
],
[
[
1005,
24,
129
],
[
129,
40,
918
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1005,
21,
28642
],
[
28642,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Vardenafil (Compound) causes Shock (Side Effect) and Shock... |
DB00398 | DB05015 | 79 | 1,077 | [
"DDInter1702",
"DDInter174"
] | Sorafenib | Belinostat | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Moderate | 1 | [
[
[
79,
24,
1077
]
],
[
[
79,
63,
482
],
[
482,
24,
1077
]
],
[
[
79,
24,
869
],
[
869,
24,
1077
]
],
[
[
79,
24,
637
],
[
637,
63,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belinostat"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Belinostat
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan... |
DB00222 | DB01232 | 245 | 1,327 | [
"DDInter825",
"DDInter1640"
] | Glimepiride | Saquinavir | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
245,
24,
1327
]
],
[
[
245,
63,
798
],
[
798,
40,
1327
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],
[
[
245,
24,
915
],
[
915,
40,
1327
]
],
[
[
245,
6,
6017
],
[
6017,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound... |
DB01174 | DB12364 | 697 | 1,421 | [
"DDInter1442",
"DDInter200"
] | Phenobarbital | Betrixaban | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
697,
24,
1421
]
],
[
[
697,
25,
1513
],
[
1513,
24,
1421
]
],
[
[
697,
40,
759
],
[
759,
24,
1421
]
],
[
[
697,
24,
971
],
[
971,
... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apremilast"
],
[
"Apre... | Phenobarbital may lead to a major life threatening interaction when taken with Apremilast and Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Phenobarbital (Compound) resembles Primidone (Compound) and Primidone may cause a moderate interaction that could exacerbate... |
DB00201 | DB01367 | 1,684 | 1,163 | [
"DDInter263",
"DDInter1572"
] | Caffeine | Rasagiline | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1684,
24,
1163
]
],
[
[
1684,
6,
7950
],
[
7950,
45,
1163
]
],
[
[
1684,
21,
28649
],
[
28649,
60,
1163
]
],
[
[
1684,
24,
985
],
[
98... | [
[
[
"Caffeine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Caffeine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Caffeine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rasagiline (Compound)
Caffeine (Compound) causes Gastrointestinal haemorrhage (Side Effect) and Gastrointestinal haemorrhage (Side Effect) is caused by Rasagiline (Compound)
Caffeine may cause a moderate interaction that could exacerbate diseases whe... |
DB00564 | DB09330 | 1,236 | 985 | [
"DDInter293",
"DDInter1352"
] | Carbamazepine | Osimertinib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1236,
25,
985
]
],
[
[
1236,
64,
168
],
[
168,
23,
985
]
],
[
[
1236,
24,
112
],
[
112,
23,
985
]
],
[
[
1236,
62,
608
],
[
608,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
... | Carbamazepine may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole... |
DB12245 | DB13139 | 823 | 1,032 | [
"DDInter1863",
"DDInter1063"
] | Triclabendazole | Levosalbutamol | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
823,
24,
1032
]
],
[
[
823,
64,
1618
],
[
1618,
24,
1032
]
],
[
[
823,
63,
124
],
[
124,
24,
1032
]
],
[
[
823,
25,
982
],
[
982,
... | [
[
[
"Triclabendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Triclabendazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
... | Triclabendazole may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Triclabendazole may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glas... |
DB00703 | DB06292 | 997 | 549 | [
"DDInter1167",
"DDInter474"
] | Methazolamide | Dapagliflozin | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
997,
24,
549
]
],
[
[
997,
24,
1344
],
[
1344,
40,
549
]
],
[
[
997,
6,
8374
],
[
8374,
45,
549
]
],
[
[
997,
21,
28882
],
[
28882,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Methazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Methazolamide (Compound) causes Body temperature... |
DB00342 | DB00877 | 1,181 | 629 | [
"DDInter1770",
"DDInter1678"
] | Terfenadine | Sirolimus | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1181,
24,
629
]
],
[
[
1181,
24,
1476
],
[
1476,
63,
629
]
],
[
[
1181,
25,
752
],
[
752,
24,
629
]
],
[
[
1181,
64,
1230
],
[
1230,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus
Terfenadine may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause... |
DB00910 | DB11901 | 1,041 | 913 | [
"DDInter1394",
"DDInter107"
] | Paricalcitol | Apalutamide | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1041,
24,
913
]
],
[
[
1041,
24,
609
],
[
609,
24,
913
]
],
[
[
1041,
24,
1619
],
[
1619,
63,
913
]
],
[
[
1041,
63,
1252
],
[
1252,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Rucapari... |
DB06228 | DB11312 | 792 | 298 | [
"DDInter1609",
"DDInter1542"
] | Rivaroxaban | Protein C | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Moderate | 1 | [
[
[
792,
24,
298
]
],
[
[
792,
25,
707
],
[
707,
24,
298
]
],
[
[
792,
24,
321
],
[
321,
63,
298
]
],
[
[
792,
64,
500
],
[
500,
24,... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparoi... | Rivaroxaban may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib and Selumetinib may cau... |
DB00026 | DB15719 | 1,184 | 487 | [
"DDInter94",
"DDInter171"
] | Anakinra | Belantamab mafodotin | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
1184,
24,
487
]
],
[
[
1184,
24,
259
],
[
259,
24,
487
]
],
[
[
1184,
25,
976
],
[
976,
25,
487
]
],
[
[
1184,
64,
1057
],
[
1057,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Anakinra may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00222 | DB06710 | 245 | 1,546 | [
"DDInter825",
"DDInter1193"
] | Glimepiride | Methyltestosterone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
245,
24,
1546
]
],
[
[
245,
24,
155
],
[
155,
1,
1546
]
],
[
[
245,
24,
984
],
[
984,
40,
1546
]
],
[
[
245,
21,
28778
],
[
28778,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Methyltestosterone (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Methylte... |
DB00595 | DB00880 | 1,545 | 359 | [
"DDInter1374",
"DDInter360"
] | Oxytetracycline | Chlorothiazide | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Minor | 0 | [
[
[
1545,
23,
359
]
],
[
[
1545,
23,
1577
],
[
1577,
1,
359
]
],
[
[
1545,
62,
811
],
[
811,
1,
359
]
],
[
[
1545,
6,
10612
],
[
10612,
... | [
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazid... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resemb... |
DB00831 | DB01105 | 1,178 | 222 | [
"DDInter1866",
"DDInter1665"
] | Trifluoperazine | Sibutramine | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1178,
24,
222
]
],
[
[
1178,
18,
9385
],
[
9385,
57,
222
]
],
[
[
1178,
21,
28852
],
[
28852,
60,
222
]
],
[
[
1178,
63,
600
],
[
600,... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) downregulates {v} (Gene)",
"MRPL19"
],
[
"MRPL19",
"{u} (Gene) is downre... | Trifluoperazine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Sibutramine (Compound)
Trifluoperazine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases ... |
DB01105 | DB01254 | 222 | 1,213 | [
"DDInter1665",
"DDInter484"
] | Sibutramine | Dasatinib | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
222,
24,
1213
]
],
[
[
222,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
222,
18,
7359
],
[
7359,
57,
1213
]
],
[
[
222,
21,
28882
],
[
28882,... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Sibutramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Sibutramine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Dasatinib (Compound)
Sibutramine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) ... |
DB00703 | DB06335 | 997 | 761 | [
"DDInter1167",
"DDInter1646"
] | Methazolamide | Saxagliptin | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
997,
24,
761
]
],
[
[
997,
6,
8374
],
[
8374,
45,
761
]
],
[
[
997,
21,
28722
],
[
28722,
60,
761
]
],
[
[
997,
63,
1573
],
[
1573,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Methazolamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Methazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Methazolamide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and... |
DB00033 | DB11988 | 342 | 270 | [
"DDInter949",
"DDInter1321"
] | Interferon gamma-1b | Ocrelizumab | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
342,
24,
270
]
],
[
[
342,
24,
713
],
[
713,
24,
270
]
],
[
[
342,
25,
1101
],
[
1101,
24,
270
]
],
[
[
342,
63,
305
],
[
305,
2... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Interferon gamma-1b may lead to a major life threatening interaction when taken with Bex... |
DB00047 | DB00624 | 176 | 1,561 | [
"DDInter932",
"DDInter1775"
] | Insulin glargine | Testosterone | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
176,
24,
1561
]
],
[
[
176,
24,
155
],
[
155,
1,
1561
]
],
[
[
176,
24,
870
],
[
870,
63,
1561
]
],
[
[
176,
24,
1026
],
[
1026,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymestero... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Testosterone (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause... |
DB00987 | DB09061 | 1,224 | 1,627 | [
"DDInter460",
"DDInter284"
] | Cytarabine | Cannabidiol | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1224,
24,
1627
]
],
[
[
1224,
24,
384
],
[
384,
23,
1627
]
],
[
[
1224,
63,
597
],
[
597,
23,
1627
]
],
[
[
1224,
24,
1613
],
[
1613,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Ch... |
DB00342 | DB04855 | 1,181 | 540 | [
"DDInter1770",
"DDInter602"
] | Terfenadine | Dronedarone | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
1181,
25,
540
]
],
[
[
1181,
64,
347
],
[
347,
40,
540
]
],
[
[
1181,
25,
33
],
[
33,
40,
540
]
],
[
[
1181,
23,
112
],
[
112,
2... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} ... | Terfenadine may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Terfenadine may cause a mino... |
DB00358 | DB04868 | 1,010 | 478 | [
"DDInter1140",
"DDInter1293"
] | Mefloquine | Nilotinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1010,
25,
478
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
478
]
],
[
[
1010,
7,
7669
],
[
7669,
46,
478
]
],
[
[
1010,
18,
2183
],
[
2183,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotinib"... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Mefloquine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Nilotinib (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Nilotinib (Compound)
Mefloquine (Compoun... |
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