drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00401 | DB01240 | 84 | 885 | [
"DDInter1298",
"DDInter657"
] | Nisoldipine | Epoprostenol | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
84,
24,
885
]
],
[
[
84,
63,
1061
],
[
1061,
1,
885
]
],
[
[
84,
21,
28684
],
[
28684,
60,
885
]
],
[
[
84,
24,
1512
],
[
1512,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Nisoldipine (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Epoprostenol (Compound)
Nisoldipine may cause a mo... |
DB00552 | DB01206 | 1,238 | 37 | [
"DDInter1425",
"DDInter1086"
] | Pentostatin | Lomustine | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
1238,
24,
37
]
],
[
[
1238,
5,
11555
],
[
11555,
44,
37
]
],
[
[
1238,
21,
28675
],
[
28675,
60,
37
]
],
[
[
1238,
62,
1176
],
[
1176,... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Pentostatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disea... | Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Pentostatin (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Lomustine (Compound)
Pentostatin may cause a minor interaction that can limit clin... |
DB00425 | DB01105 | 558 | 222 | [
"DDInter1970",
"DDInter1665"
] | Zolpidem | Sibutramine | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
558,
24,
222
]
],
[
[
558,
6,
8374
],
[
8374,
45,
222
]
],
[
[
558,
21,
29356
],
[
29356,
60,
222
]
],
[
[
558,
24,
384
],
[
384,
... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Zolpidem",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Zolpidem (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Zolpidem (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00445 | DB00927 | 322 | 1,559 | [
"DDInter655",
"DDInter712"
] | Epirubicin | Famotidine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
322,
24,
1559
]
],
[
[
322,
7,
3492
],
[
3492,
46,
1559
]
],
[
[
322,
18,
1918
],
[
1918,
57,
1559
]
],
[
[
322,
21,
28826
],
[
28826,... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Epirubicin",
"{u} (Compound) upregulates {v} (Gene)",
"E2F2"
],
[
"E2F2",
"{u} (Gene) is upregulated by {v} (Com... | Epirubicin (Compound) upregulates E2F2 (Gene) and E2F2 (Gene) is upregulated by Famotidine (Compound)
Epirubicin (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Famotidine (Compound)
Epirubicin (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound... |
DB00065 | DB06043 | 581 | 1,644 | [
"DDInter923",
"DDInter1328"
] | Infliximab | Olaratumab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Major | 2 | [
[
[
581,
25,
1644
]
],
[
[
581,
25,
1531
],
[
1531,
63,
1644
]
],
[
[
581,
64,
1184
],
[
1184,
24,
1644
]
],
[
[
581,
24,
1367
],
[
1367,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaratumab"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Canakinumab"
],
[
"Canakinumab",
"{u}... | Infliximab may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaratumab
Infliximab may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cause a moderate intera... |
DB00015 | DB01088 | 582 | 714 | [
"DDInter1585",
"DDInter908"
] | Reteplase | Iloprost | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
582,
24,
714
]
],
[
[
582,
23,
539
],
[
539,
62,
714
]
],
[
[
582,
24,
1638
],
[
1638,
24,
714
]
],
[
[
582,
25,
1432
],
[
1432,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Cap... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Iloprost
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril may... |
DB00744 | DB08820 | 1,288 | 1,478 | [
"DDInter1962",
"DDInter997"
] | Zileuton | Ivacaftor | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1288,
24,
1478
]
],
[
[
1288,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1288,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1288,
24,
985
],
[
98... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Zileuton",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Zileuton (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Zileuton (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimertinib m... |
DB00818 | DB11986 | 898 | 484 | [
"DDInter1538",
"DDInter648"
] | Propofol | Entrectinib | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
898,
24,
484
]
],
[
[
898,
23,
112
],
[
112,
23,
484
]
],
[
[
898,
24,
774
],
[
774,
24,
484
]
],
[
[
898,
63,
1674
],
[
1674,
2... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Propofol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Propofol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degareli... |
DB01224 | DB01268 | 623 | 1,151 | [
"DDInter1553",
"DDInter1731"
] | Quetiapine | Sunitinib | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
623,
24,
1151
]
],
[
[
623,
25,
1311
],
[
1311,
1,
1151
]
],
[
[
623,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
623,
18,
17504
],
[
17504,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Quetiapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
"Metoclo... | Quetiapine may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Quetiapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Quetiapine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is down... |
DB00280 | DB00424 | 494 | 19 | [
"DDInter575",
"DDInter896"
] | Disopyramide | Hyoscyamine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
494,
24,
19
]
],
[
[
494,
25,
1166
],
[
1166,
1,
19
]
],
[
[
494,
24,
85
],
[
85,
63,
19
]
],
[
[
494,
6,
4304
],
[
4304,
45,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
],
[
"Dolas... | Disopyramide may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate di... |
DB00322 | DB01073 | 141 | 1,488 | [
"DDInter742",
"DDInter745"
] | Floxuridine | Fludarabine | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
141,
24,
1488
]
],
[
[
141,
24,
372
],
[
372,
1,
1488
]
],
[
[
141,
21,
28701
],
[
28701,
60,
1488
]
],
[
[
141,
23,
839
],
[
839,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Floxuridine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Fludarabine (Compound)
Floxuridine may cause a minor intera... |
DB00553 | DB00982 | 92 | 1,517 | [
"DDInter1177",
"DDInter991"
] | Methoxsalen | Isotretinoin | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
92,
24,
1517
]
],
[
[
92,
63,
640
],
[
640,
25,
1517
]
],
[
[
92,
7,
7972
],
[
7972,
46,
1517
]
],
[
[
92,
18,
7039
],
[
7039,
5... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acitretin"
],
[... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Methoxsalen (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Isotretinoin (Compound)
Methoxsalen (Co... |
DB00363 | DB00631 | 695 | 372 | [
"DDInter419",
"DDInter405"
] | Clozapine | Clofarabine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Major | 2 | [
[
[
695,
25,
372
]
],
[
[
695,
25,
1426
],
[
1426,
40,
372
]
],
[
[
695,
64,
1064
],
[
1064,
25,
372
]
],
[
[
695,
18,
17366
],
[
17366,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofarabine"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azacitidine"
],
[
"Azacitidine",
"{u} ... | Clozapine may lead to a major life threatening interaction when taken with Azacitidine and Azacitidine (Compound) resembles Clofarabine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Clofara... |
DB06810 | DB11601 | 397 | 1,270 | [
"DDInter1484",
"DDInter1889"
] | Plicamycin | Tuberculin purified protein derivative | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
397,
24,
1270
]
],
[
[
397,
63,
1531
],
[
1531,
24,
1270
]
],
[
[
397,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
397,
25,
1259
],
[
1259,
... | [
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Plicamycin may lead to a major life threatening interaction when taken with Cladri... |
DB08918 | DB09268 | 41 | 1,662 | [
"DDInter1059",
"DDInter1464"
] | Levomilnacipran | Picosulfuric acid | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
41,
24,
1662
]
],
[
[
41,
63,
1618
],
[
1618,
24,
1662
]
],
[
[
41,
64,
73
],
[
73,
24,
1662
]
],
[
[
41,
1,
1349
],
[
1349,
24,... | [
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantin... | Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Levomilnacipran may lead to a major life threatening interaction when taken with Phentermine and... |
DB00472 | DB00836 | 758 | 543 | [
"DDInter758",
"DDInter1088"
] | Fluoxetine | Loperamide | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
758,
24,
543
]
],
[
[
758,
24,
649
],
[
649,
1,
543
]
],
[
[
758,
25,
888
],
[
888,
24,
543
]
],
[
[
758,
63,
1242
],
[
1242,
24... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Fluoxetine may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate disea... |
DB00013 | DB11071 | 1,255 | 1,004 | [
"DDInter1905",
"DDInter1449"
] | Urokinase | Phenyl salicylate | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1255,
24,
1004
]
],
[
[
1255,
25,
500
],
[
500,
24,
1004
]
],
[
[
1255,
25,
235
],
[
235,
63,
1004
]
],
[
[
1255,
24,
885
],
[
885,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
"Enoxa... | Urokinase may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Urokinase may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a moderate i... |
DB01004 | DB09054 | 563 | 384 | [
"DDInter806",
"DDInter905"
] | Ganciclovir | Idelalisib | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
563,
24,
384
]
],
[
[
563,
24,
328
],
[
328,
24,
384
]
],
[
[
563,
63,
305
],
[
305,
24,
384
]
],
[
[
563,
24,
1619
],
[
1619,
6... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
],
... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Asparaginas... |
DB00816 | DB01100 | 1,674 | 1,568 | [
"DDInter1346",
"DDInter1470"
] | Orciprenaline | Pimozide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
1674,
25,
1568
]
],
[
[
1674,
64,
78
],
[
78,
40,
1568
]
],
[
[
1674,
63,
1557
],
[
1557,
25,
1568
]
],
[
[
1674,
18,
16549
],
[
16549... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{... | Orciprenaline may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may lead to a major life threatening interaction when ... |
DB00572 | DB01122 | 85 | 158 | [
"DDInter136",
"DDInter61"
] | Atropine | Ambenonium | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Moderate | 1 | [
[
[
85,
24,
158
]
],
[
[
85,
63,
352
],
[
352,
24,
158
]
],
[
[
85,
24,
262
],
[
262,
24,
158
]
],
[
[
85,
35,
1442
],
[
1442,
24,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambenonium"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
"T... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Ambenonium
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may c... |
DB00405 | DB00980 | 128 | 969 | [
"DDInter517",
"DDInter1564"
] | Dexbrompheniramine | Ramelteon | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
128,
24,
969
]
],
[
[
128,
24,
100
],
[
100,
24,
969
]
],
[
[
128,
63,
1242
],
[
1242,
24,
969
]
],
[
[
128,
24,
649
],
[
649,
6... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniram... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00909 | DB01105 | 306 | 222 | [
"DDInter1971",
"DDInter1665"
] | Zonisamide | Sibutramine | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
306,
24,
222
]
],
[
[
306,
6,
8374
],
[
8374,
45,
222
]
],
[
[
306,
21,
29215
],
[
29215,
60,
222
]
],
[
[
306,
24,
384
],
[
384,
... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Zonisamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Zonisamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Zonisamide (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Sibutramine (Compound)
Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and ... |
DB01319 | DB05239 | 34 | 866 | [
"DDInter777",
"DDInter425"
] | Fosamprenavir | Cobimetinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
34,
25,
866
]
],
[
[
34,
24,
214
],
[
214,
63,
866
]
],
[
[
34,
63,
1051
],
[
1051,
24,
866
]
],
[
[
34,
25,
1478
],
[
1478,
63,... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"F... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Aminoglute... |
DB00334 | DB12332 | 867 | 1,619 | [
"DDInter1326",
"DDInter1626"
] | Olanzapine | Rucaparib | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
867,
24,
1619
]
],
[
[
867,
24,
222
],
[
222,
23,
1619
]
],
[
[
867,
23,
112
],
[
112,
23,
1619
]
],
[
[
867,
1,
87
],
[
87,
24,... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00342 | DB01069 | 1,181 | 401 | [
"DDInter1770",
"DDInter1533"
] | Terfenadine | Promethazine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1181,
24,
401
]
],
[
[
1181,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1181,
24,
1236
],
[
1236,
24,
401
]
],
[
[
1181,
24,
286
],
[
286,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carba... |
DB06643 | DB09331 | 1,136 | 745 | [
"DDInter500",
"DDInter478"
] | Denosumab | Daratumumab | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Moderate | 1 | [
[
[
1136,
24,
745
]
],
[
[
1136,
63,
4
],
[
4,
24,
745
]
],
[
[
1136,
24,
1362
],
[
1362,
24,
745
]
],
[
[
1136,
24,
270
],
[
270,
6... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daratumumab"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Daratumumab
Denosumab may cause a moderate interaction that could exacerbate diseases when tak... |
DB01100 | DB09020 | 1,568 | 28 | [
"DDInter1470",
"DDInter212"
] | Pimozide | Bisacodyl | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1568,
24,
28
]
],
[
[
1568,
63,
662
],
[
662,
1,
28
]
],
[
[
1568,
63,
128
],
[
128,
40,
28
]
],
[
[
1568,
24,
272
],
[
272,
40,... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles Bisac... |
DB00762 | DB01135 | 613 | 648 | [
"DDInter973",
"DDInter590"
] | Irinotecan | Doxacurium | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. | Minor | 0 | [
[
[
613,
23,
648
]
],
[
[
613,
23,
1319
],
[
1319,
40,
648
]
],
[
[
613,
6,
10558
],
[
10558,
45,
648
]
],
[
[
613,
24,
1220
],
[
1220,
... | [
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doxacurium"
]
],
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mivacurium"
],
[
... | Irinotecan may cause a minor interaction that can limit clinical effects when taken with Mivacurium and Mivacurium (Compound) resembles Doxacurium (Compound)
Irinotecan (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Doxacurium (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseas... |
DB06209 | DB08901 | 256 | 1,468 | [
"DDInter1508",
"DDInter1492"
] | Prasugrel | Ponatinib | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
256,
25,
1468
]
],
[
[
256,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
256,
21,
29024
],
[
29024,
60,
1468
]
],
[
[
256,
62,
1194
],
[
1194,... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Prasugrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ponatinib"... | Prasugrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Prasugrel (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Ponatinib (Compound)
Prasugrel may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranit... |
DB00557 | DB09268 | 252 | 1,662 | [
"DDInter895",
"DDInter1464"
] | Hydroxyzine | Picosulfuric acid | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
252,
24,
1662
]
],
[
[
252,
24,
484
],
[
484,
63,
1662
]
],
[
[
252,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
252,
24,
1491
],
[
1491,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Hydroxyzine may lead to a major life threatening interaction when taken with Cabozantinib and Cabozant... |
DB00701 | DB11827 | 1,091 | 433 | [
"DDInter90",
"DDInter669"
] | Amprenavir | Ertugliflozin | Amprenavir is a protease inhibitor used to treat HIV infection. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1091,
24,
433
]
],
[
[
1091,
24,
959
],
[
959,
24,
433
]
],
[
[
1091,
63,
251
],
[
251,
24,
433
]
],
[
[
1091,
23,
609
],
[
609,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Be... |
DB00910 | DB01324 | 1,041 | 178 | [
"DDInter1394",
"DDInter1490"
] | Paricalcitol | Polythiazide | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
1041,
24,
178
]
],
[
[
1041,
24,
674
],
[
674,
40,
178
]
],
[
[
1041,
63,
359
],
[
359,
40,
178
]
],
[
[
1041,
21,
28852
],
[
28852,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) re... |
DB00620 | DB04575 | 175 | 35 | [
"DDInter1855",
"DDInter1555"
] | Triamcinolone | Quinestrol | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
175,
24,
35
]
],
[
[
175,
24,
890
],
[
890,
1,
35
]
],
[
[
175,
63,
380
],
[
380,
1,
35
]
],
[
[
175,
23,
771
],
[
771,
62,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) resemble... |
DB00005 | DB11703 | 1,057 | 405 | [
"DDInter687",
"DDInter9"
] | Etanercept | Acalabrutinib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1057,
25,
405
]
],
[
[
1057,
25,
139
],
[
139,
24,
405
]
],
[
[
1057,
24,
58
],
[
58,
24,
405
]
],
[
[
1057,
24,
151
],
[
151,
6... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
"Zidovudine",
"{u... | Etanercept may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause... |
DB00283 | DB00719 | 701 | 1,219 | [
"DDInter395",
"DDInter149"
] | Clemastine | Azatadine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
701,
24,
1219
]
],
[
[
701,
24,
13
],
[
13,
24,
1219
]
],
[
[
701,
24,
830
],
[
830,
1,
1219
]
],
[
[
701,
6,
8374
],
[
8374,
45... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine a... |
DB00978 | DB06792 | 739 | 1,606 | [
"DDInter1084",
"DDInter1023"
] | Lomefloxacin | Lanthanum carbonate | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
739,
24,
1606
]
],
[
[
739,
40,
1299
],
[
1299,
24,
1606
]
],
[
[
739,
1,
945
],
[
945,
24,
1606
]
],
[
[
739,
25,
1487
],
[
1487,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Trovafloxacin"
],
[
"Trovafloxacin",
"{u} ... | Lomefloxacin (Compound) resembles Trovafloxacin (Compound) and Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Lomefloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseases when... |
DB00457 | DB00902 | 1,205 | 104 | [
"DDInter1511",
"DDInter1168"
] | Prazosin | Methdilazine | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1205,
24,
104
]
],
[
[
1205,
24,
820
],
[
820,
1,
104
]
],
[
[
1205,
24,
401
],
[
401,
63,
104
]
],
[
[
1205,
63,
475
],
[
475,
... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that c... |
DB00353 | DB06589 | 588 | 1,250 | [
"DDInter1187",
"DDInter1400"
] | Methylergometrine | Pazopanib | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
588,
24,
1250
]
],
[
[
588,
6,
8374
],
[
8374,
45,
1250
]
],
[
[
588,
18,
16641
],
[
16641,
46,
1250
]
],
[
[
588,
7,
16192
],
[
16192... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Methylergometrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Methylergometrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound)
Methylergometrine (Compound) downregulates LYPLA1 (Gene) and LYPLA1 (Gene) is upregulated by Pazopanib (Compound)
Methylergometrine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Pazopanib (... |
DB00619 | DB09039 | 1,419 | 1,670 | [
"DDInter909",
"DDInter629"
] | Imatinib | Eliglustat | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
1419,
25,
1670
]
],
[
[
1419,
23,
479
],
[
479,
23,
1670
]
],
[
[
1419,
24,
211
],
[
211,
23,
1670
]
],
[
[
1419,
25,
1135
],
[
1135,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
"Donepezil",
... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine may... |
DB00023 | DB00595 | 305 | 1,545 | [
"DDInter127",
"DDInter1374"
] | Asparaginase Escherichia coli | Oxytetracycline | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Moderate | 1 | [
[
[
305,
24,
1545
]
],
[
[
305,
24,
964
],
[
964,
1,
1545
]
],
[
[
305,
24,
45
],
[
45,
62,
1545
]
],
[
[
305,
24,
1254
],
[
1254,
6... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxytetracycline"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Oxytetracycline (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosin... |
DB00197 | DB11581 | 1,324 | 1,456 | [
"DDInter1881",
"DDInter1926"
] | Troglitazone | Venetoclax | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
1324,
24,
1456
]
],
[
[
1324,
24,
1135
],
[
1135,
23,
1456
]
],
[
[
1324,
24,
1476
],
[
1476,
63,
1456
]
],
[
[
1324,
24,
984
],
[
984... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigat... |
DB00557 | DB01168 | 252 | 1,053 | [
"DDInter895",
"DDInter1526"
] | Hydroxyzine | Procarbazine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
252,
24,
1053
]
],
[
[
252,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
252,
24,
480
],
[
480,
24,
1053
]
],
[
[
252,
24,
830
],
[
830,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is ca... | Hydroxyzine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Proca... |
DB06595 | DB08871 | 1,491 | 36 | [
"DDInter1214",
"DDInter666"
] | Midostaurin | Eribulin | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1491,
24,
36
]
],
[
[
1491,
63,
122
],
[
122,
23,
36
]
],
[
[
1491,
62,
1247
],
[
1247,
23,
36
]
],
[
[
1491,
63,
519
],
[
519,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Midostaurin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfam... |
DB00424 | DB09128 | 19 | 1,241 | [
"DDInter896",
"DDInter231"
] | Hyoscyamine | Brexpiprazole | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
19,
24,
1241
]
],
[
[
19,
24,
407
],
[
407,
63,
1241
]
],
[
[
19,
24,
543
],
[
543,
24,
1241
]
],
[
[
19,
63,
701
],
[
701,
24,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide ... |
DB00035 | DB06700 | 1,314 | 643 | [
"DDInter507",
"DDInter511"
] | Desmopressin | Desvenlafaxine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
1314,
24,
643
]
],
[
[
1314,
24,
1100
],
[
1100,
1,
643
]
],
[
[
1314,
21,
28709
],
[
28709,
60,
643
]
],
[
[
1314,
24,
1574
],
[
1574... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Desmopressin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Desvenlafaxine (Compound)
Desmopressin... |
DB06292 | DB12267 | 549 | 1,476 | [
"DDInter474",
"DDInter233"
] | Dapagliflozin | Brigatinib | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
549,
24,
1476
]
],
[
[
549,
63,
168
],
[
168,
23,
1476
]
],
[
[
549,
63,
629
],
[
629,
24,
1476
]
],
[
[
549,
62,
79
],
[
79,
24... | [
[
[
"Dapagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Dapagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sir... |
DB01067 | DB01203 | 959 | 699 | [
"DDInter826",
"DDInter1255"
] | Glipizide | Nadolol | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
959,
24,
699
]
],
[
[
959,
24,
729
],
[
729,
1,
699
]
],
[
[
959,
63,
887
],
[
887,
1,
699
]
],
[
[
959,
21,
29316
],
[
29316,
6... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
[
"... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Nadolol (Compound)
Glipizide (C... |
DB00550 | DB14730 | 99 | 1,412 | [
"DDInter1541",
"DDInter264"
] | Propylthiouracil | Calaspargase pegol | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
99,
24,
1412
]
],
[
[
99,
63,
322
],
[
322,
24,
1412
]
],
[
[
99,
24,
850
],
[
850,
24,
1412
]
],
[
[
99,
25,
1377
],
[
1377,
25... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubi... | Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with B... |
DB00910 | DB12332 | 1,041 | 1,619 | [
"DDInter1394",
"DDInter1626"
] | Paricalcitol | Rucaparib | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1041,
24,
1619
]
],
[
[
1041,
24,
159
],
[
159,
63,
1619
]
],
[
[
1041,
63,
215
],
[
215,
24,
1619
]
],
[
[
1041,
24,
913
],
[
913,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Indinavir an... |
DB00564 | DB01285 | 1,236 | 708 | [
"DDInter293",
"DDInter445"
] | Carbamazepine | Corticotropin | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1236,
24,
708
]
],
[
[
1236,
24,
126
],
[
126,
24,
708
]
],
[
[
1236,
63,
1324
],
[
1324,
24,
708
]
],
[
[
1236,
24,
1450
],
[
1450,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and... |
DB00321 | DB00916 | 21 | 112 | [
"DDInter78",
"DDInter1202"
] | Amitriptyline | Metronidazole | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
21,
23,
112
]
],
[
[
21,
6,
3486
],
[
3486,
45,
112
]
],
[
[
21,
21,
28757
],
[
28757,
60,
112
]
],
[
[
21,
63,
618
],
[
618,
23... | [
[
[
"Amitriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Comp... | Amitriptyline (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Amitriptyline (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Metronidazole (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Abar... |
DB00396 | DB09043 | 989 | 135 | [
"DDInter1529",
"DDInter36"
] | Progesterone | Albiglutide | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in var... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
989,
24,
135
]
],
[
[
989,
63,
1647
],
[
1647,
23,
135
]
],
[
[
989,
40,
870
],
[
870,
24,
135
]
],
[
[
989,
63,
176
],
[
176,
2... | [
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[... | Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Progesterone (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction t... |
DB00515 | DB00694 | 589 | 51 | [
"DDInter387",
"DDInter485"
] | Cisplatin | Daunorubicin | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
589,
24,
51
]
],
[
[
589,
5,
11555
],
[
11555,
44,
51
]
],
[
[
589,
6,
4973
],
[
4973,
45,
51
]
],
[
[
589,
21,
28822
],
[
28822,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Cisplatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Diseas... | Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Daunorubicin (Compound)
Cisplatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Daunorubicin (Compound)
Cisplatin (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Daunorub... |
DB01611 | DB05294 | 1,487 | 1,069 | [
"DDInter893",
"DDInter1917"
] | Hydroxychloroquine | Vandetanib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1487,
25,
1069
]
],
[
[
1487,
21,
28719
],
[
28719,
60,
1069
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
1069
]
],
[
[
1487,
63,
112
],
[
1... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Hydroxychloroquine",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v}... | Hydroxychloroquine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when take... |
DB00443 | DB00532 | 251 | 208 | [
"DDInter195",
"DDInter1152"
] | Betamethasone | Mephenytoin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
251,
24,
208
]
],
[
[
251,
25,
908
],
[
908,
63,
208
]
],
[
[
251,
63,
599
],
[
599,
24,
208
]
],
[
[
251,
24,
4
],
[
4,
63,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
],
[
"Goli... | Betamethasone may lead to a major life threatening interaction when taken with Golimumab and Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Mephenytoin
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may... |
DB01234 | DB14740 | 1,220 | 771 | [
"DDInter513",
"DDInter881"
] | Dexamethasone | Hyaluronidase | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1220,
23,
771
]
],
[
[
1220,
63,
1438
],
[
1438,
23,
771
]
],
[
[
1220,
40,
167
],
[
167,
23,
771
]
],
[
[
1220,
1,
617
],
[
617,
... | [
[
[
"Dexamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Dexamethasone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction ... |
DB00218 | DB00361 | 1,176 | 134 | [
"DDInter1247",
"DDInter1939"
] | Moxifloxacin | Vinorelbine | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Minor | 0 | [
[
[
1176,
23,
134
]
],
[
[
1176,
23,
147
],
[
147,
63,
134
]
],
[
[
1176,
6,
3199
],
[
3199,
57,
134
]
],
[
[
1176,
21,
29434
],
[
29434,
... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vinorelbine"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vinblastine"
],
[
... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Vinorelbine (Compound)
Moxifl... |
DB00461 | DB05578 | 598 | 330 | [
"DDInter1254",
"DDInter1566"
] | Nabumetone | Ramucirumab | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
598,
25,
330
]
],
[
[
598,
24,
384
],
[
384,
63,
330
]
],
[
[
598,
24,
222
],
[
222,
24,
330
]
],
[
[
598,
24,
1317
],
[
1317,
2... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
"Idelalisi... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibu... |
DB00227 | DB11837 | 1,463 | 1,297 | [
"DDInter1098",
"DDInter1351"
] | Lovastatin | Osilodrostat | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1463,
24,
1297
]
],
[
[
1463,
24,
112
],
[
112,
23,
1297
]
],
[
[
1463,
24,
466
],
[
466,
62,
1297
]
],
[
[
1463,
24,
578
],
[
578,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide an... |
DB00782 | DB01246 | 1,123 | 820 | [
"DDInter1535",
"DDInter45"
] | Propantheline | Alimemazine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1123,
24,
820
]
],
[
[
1123,
24,
358
],
[
358,
24,
820
]
],
[
[
1123,
24,
104
],
[
104,
40,
820
]
],
[
[
1123,
63,
675
],
[
675,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Methdilazi... |
DB00981 | DB01136 | 1,528 | 772 | [
"DDInter1462",
"DDInter305"
] | Physostigmine | Carvedilol | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
1528,
24,
772
]
],
[
[
1528,
21,
28722
],
[
28722,
60,
772
]
],
[
[
1528,
24,
770
],
[
770,
24,
772
]
],
[
[
1528,
25,
497
],
[
497,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Physostigmine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caus... | Physostigmine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Carvedilol (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Carve... |
DB01267 | DB01611 | 519 | 1,487 | [
"DDInter1381",
"DDInter893"
] | Paliperidone | Hydroxychloroquine | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
519,
25,
1487
]
],
[
[
519,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
519,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
519,
21,
28658
],
[
2865... | [
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Paliperidone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Paliperidone ... |
DB12015 | DB12141 | 1,033 | 971 | [
"DDInter53",
"DDInter817"
] | Alpelisib | Gilteritinib | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α, which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolis... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1033,
24,
971
]
],
[
[
1033,
62,
1135
],
[
1135,
23,
971
]
],
[
[
1033,
63,
1247
],
[
1247,
23,
971
]
],
[
[
1033,
24,
466
],
[
466,
... | [
[
[
"Alpelisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Alpelisib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Alpelisib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfam... |
DB00357 | DB12301 | 1,051 | 907 | [
"DDInter71",
"DDInter585"
] | Aminoglutethimide | Doravirine | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Moderate | 1 | [
[
[
1051,
24,
907
]
],
[
[
1051,
24,
1478
],
[
1478,
23,
907
]
],
[
[
1051,
24,
159
],
[
159,
62,
907
]
],
[
[
1051,
24,
978
],
[
978,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectin... |
DB00358 | DB05541 | 1,010 | 801 | [
"DDInter1140",
"DDInter239"
] | Mefloquine | Brivaracetam | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
1010,
24,
801
]
],
[
[
1010,
24,
477
],
[
477,
23,
801
]
],
[
[
1010,
63,
600
],
[
600,
23,
801
]
],
[
[
1010,
24,
1374
],
[
1374,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a minor interaction that can limit clinical effects when taken with Brivaracetam
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluco... |
DB08901 | DB12364 | 1,468 | 1,421 | [
"DDInter1492",
"DDInter200"
] | Ponatinib | Betrixaban | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1468,
25,
1421
]
],
[
[
1468,
64,
1091
],
[
1091,
24,
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[
[
1468,
24,
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],
[
1017,
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],
[
[
1468,
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529
],
[
529... | [
[
[
"Ponatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Ponatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Amprenavir",
"{u} may... | Ponatinib may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a ... |
DB00011 | DB00951 | 1,451 | 1,072 | [
"DDInter944",
"DDInter986"
] | Interferon alfa-n1 | Isoniazid | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1451,
24,
1072
]
],
[
[
1451,
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],
[
1031,
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[
[
1451,
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[
309,
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],
[
[
1451,
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491
],
[
491,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Ix... |
DB01241 | DB11995 | 1,206 | 1,634 | [
"DDInter812",
"DDInter143"
] | Gemfibrozil | Avatrombopag | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
1206,
24,
1634
]
],
[
[
1206,
24,
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],
[
913,
24,
1634
]
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[
[
1206,
24,
1040
],
[
1040,
25,
1634
]
],
[
[
1206,
24,
913
],
[
913,
... | [
[
[
"Gemfibrozil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Gemfibrozil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
],
... | Gemfibrozil may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Gemfibrozil may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and ... |
DB00465 | DB01240 | 886 | 885 | [
"DDInter1010",
"DDInter657"
] | Ketorolac | Epoprostenol | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
886,
24,
885
]
],
[
[
886,
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],
[
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]
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[
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886,
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28936
],
[
28936,
60,
885
]
],
[
[
886,
25,
1512
],
[
1512,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Ketorolac (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Epoprostenol (Compound)
Ketorolac may lead to a major ... |
DB00377 | DB12161 | 1,494 | 730 | [
"DDInter1382",
"DDInter512"
] | Palonosetron | Deutetrabenazine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
1494,
24,
730
]
],
[
[
1494,
23,
112
],
[
112,
23,
730
]
],
[
[
1494,
24,
322
],
[
322,
24,
730
]
],
[
[
1494,
25,
1264
],
[
1264,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Epirubici... |
DB00374 | DB15233 | 1,061 | 1,650 | [
"DDInter1852",
"DDInter142"
] | Treprostinil | Avapritinib | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1061,
25,
1650
]
],
[
[
1061,
24,
1374
],
[
1374,
24,
1650
]
],
[
[
1061,
24,
1512
],
[
1512,
25,
1650
]
],
[
[
1061,
25,
4
],
[
4,
... | [
[
[
"Treprostinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
"Abir... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and... |
DB00564 | DB12941 | 1,236 | 466 | [
"DDInter293",
"DDInter481"
] | Carbamazepine | Darolutamide | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Major | 2 | [
[
[
1236,
25,
466
]
],
[
[
1236,
25,
1374
],
[
1374,
23,
466
]
],
[
[
1236,
63,
600
],
[
600,
23,
466
]
],
[
[
1236,
24,
86
],
[
86,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",
... | Carbamazepine may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole ... |
DB00280 | DB09020 | 494 | 28 | [
"DDInter575",
"DDInter212"
] | Disopyramide | Bisacodyl | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
494,
24,
28
]
],
[
[
494,
24,
662
],
[
662,
1,
28
]
],
[
[
494,
24,
128
],
[
128,
40,
28
]
],
[
[
494,
21,
28809
],
[
28809,
60,... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembl... |
DB00889 | DB05294 | 1,133 | 1,069 | [
"DDInter840",
"DDInter1917"
] | Granisetron | Vandetanib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1133,
25,
1069
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
1133,
21,
28719
],
[
28719,
60,
1069
]
],
[
[
1133,
23,
1247
],
[
1... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vande... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Granisetron (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfame... |
DB00586 | DB00812 | 1,512 | 998 | [
"DDInter537",
"DDInter1451"
] | Diclofenac | Phenylbutazone | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
1512,
24,
998
]
],
[
[
1512,
24,
804
],
[
804,
40,
998
]
],
[
[
1512,
23,
307
],
[
307,
1,
998
]
],
[
[
1512,
6,
16560
],
[
16560,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
],
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone and Sulfinpyrazone (Compound) resembles Phenylbutazone (Compound)
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Phenylbutazone... |
DB00959 | DB04575 | 1,486 | 35 | [
"DDInter1191",
"DDInter1555"
] | Methylprednisolone | Quinestrol | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
1486,
24,
35
]
],
[
[
1486,
24,
890
],
[
890,
1,
35
]
],
[
[
1486,
63,
559
],
[
559,
1,
35
]
],
[
[
1486,
23,
771
],
[
771,
62,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Estrone and Estrone (Compound) resembles Quinestrol (Co... |
DB01072 | DB13928 | 915 | 1,385 | [
"DDInter129",
"DDInter1660"
] | Atazanavir | Semaglutide | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
915,
24,
1385
]
],
[
[
915,
24,
1154
],
[
1154,
24,
1385
]
],
[
[
915,
63,
891
],
[
891,
24,
1385
]
],
[
[
915,
25,
1476
],
[
1476,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
],
[
... | Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and P... |
DB00450 | DB09020 | 78 | 28 | [
"DDInter603",
"DDInter212"
] | Droperidol | Bisacodyl | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
78,
24,
28
]
],
[
[
78,
24,
662
],
[
662,
1,
28
]
],
[
[
78,
63,
128
],
[
128,
40,
28
]
],
[
[
78,
24,
272
],
[
272,
40,
2... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles B... |
DB08912 | DB13074 | 1,040 | 877 | [
"DDInter462",
"DDInter1110"
] | Dabrafenib | Macimorelin | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
1040,
24,
877
]
],
[
[
1040,
63,
1247
],
[
1247,
23,
877
]
],
[
[
1040,
24,
1320
],
[
1320,
24,
877
]
],
[
[
1040,
63,
651
],
[
651,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix a... |
DB00393 | DB01172 | 854 | 416 | [
"DDInter1295",
"DDInter1004"
] | Nimodipine | Kanamycin | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
854,
24,
416
]
],
[
[
854,
21,
28680
],
[
28680,
60,
416
]
],
[
[
854,
24,
1512
],
[
1512,
24,
416
]
],
[
[
854,
24,
1532
],
[
1532,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Nimodipine",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (... | Nimodipine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Kanamycin (Compound)
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin
Nimodipi... |
DB00014 | DB06616 | 521 | 594 | [
"DDInter839",
"DDInter224"
] | Goserelin | Bosutinib | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
521,
24,
594
]
],
[
[
521,
21,
29231
],
[
29231,
60,
594
]
],
[
[
521,
23,
112
],
[
112,
23,
594
]
],
[
[
521,
24,
1559
],
[
1559,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Side Effe... | Goserelin (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Bosutinib (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB01242 | DB09076 | 1,237 | 1,116 | [
"DDInter410",
"DDInter1899"
] | Clomipramine | Umeclidinium | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1237,
24,
1116
]
],
[
[
1237,
24,
849
],
[
849,
24,
1116
]
],
[
[
1237,
63,
401
],
[
401,
24,
1116
]
],
[
[
1237,
74,
662
],
[
662,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine an... |
DB01073 | DB06273 | 1,488 | 980 | [
"DDInter745",
"DDInter1824"
] | Fludarabine | Tocilizumab | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1488,
24,
980
]
],
[
[
1488,
63,
1461
],
[
1461,
23,
980
]
],
[
[
1488,
63,
139
],
[
139,
24,
980
]
],
[
[
1488,
24,
309
],
[
309,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tocilizumab
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovud... |
DB00621 | DB00860 | 1,026 | 891 | [
"DDInter1357",
"DDInter1513"
] | Oxandrolone | Prednisolone | A synthetic hormone with anabolic and androgenic properties. | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1026,
24,
891
]
],
[
[
1026,
40,
989
],
[
989,
1,
891
]
],
[
[
1026,
63,
175
],
[
175,
40,
891
]
],
[
[
1026,
40,
1561
],
[
1561,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Oxandrolone",
"{u} (Compound) resembles {v} (Compound)",
"Progesterone"
],
[
"Progesterone",
"{u} (Compound) ... | Oxandrolone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Prednisolone (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Oxandrolone (Compound) resembles... |
DB00757 | DB01045 | 1,166 | 463 | [
"DDInter581",
"DDInter1590"
] | Dolasetron | Rifampicin | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Minor | 0 | [
[
[
1166,
23,
463
]
],
[
[
1166,
62,
690
],
[
690,
40,
463
]
],
[
[
1166,
6,
6017
],
[
6017,
45,
463
]
],
[
[
1166,
25,
1264
],
[
1264,
... | [
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifampicin"
]
],
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifabutin"
],
[
"... | Dolasetron may cause a minor interaction that can limit clinical effects when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Dolasetron (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Rifampicin (Compound)
Dolasetron may lead to a major life threatening interaction when taken... |
DB00629 | DB11921 | 390 | 1,019 | [
"DDInter844",
"DDInter492"
] | Guanabenz | Deflazacort | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem] | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
390,
24,
1019
]
],
[
[
390,
24,
1344
],
[
1344,
24,
1019
]
],
[
[
390,
1,
1364
],
[
1364,
24,
1019
]
],
[
[
390,
24,
1220
],
[
1220,
... | [
[
[
"Guanabenz",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Guanabenz",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
... | Guanabenz may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Guanabenz (Compound) resembles Guanfacine (Compound) and Guanfacine may cause a moderate interaction that ... |
DB00598 | DB01088 | 1,523 | 714 | [
"DDInter1013",
"DDInter908"
] | Labetalol | Iloprost | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1523,
24,
714
]
],
[
[
1523,
23,
1479
],
[
1479,
24,
714
]
],
[
[
1523,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1523,
24,
1445
],
[
1445,... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Labetalol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
],
... | Labetalol may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Aldesle... |
DB00331 | DB00367 | 1,645 | 566 | [
"DDInter1164",
"DDInter1061"
] | Metformin | Levonorgestrel | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Moderate | 1 | [
[
[
1645,
24,
566
]
],
[
[
1645,
63,
1336
],
[
1336,
40,
566
]
],
[
[
1645,
24,
35
],
[
35,
40,
566
]
],
[
[
1645,
63,
1657
],
[
1657,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestrel"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Etonogestrel and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Levonorgestrel (... |
DB12332 | DB14840 | 1,619 | 861 | [
"DDInter1626",
"DDInter1601"
] | Rucaparib | Ripretinib | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1619,
24,
861
]
],
[
[
1619,
64,
351
],
[
351,
24,
861
]
],
[
[
1619,
63,
392
],
[
392,
24,
861
]
],
[
[
1619,
24,
159
],
[
159,
... | [
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Rucaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",... | Rucaparib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a mo... |
DB00994 | DB01129 | 361 | 379 | [
"DDInter1277",
"DDInter1559"
] | Neomycin | Rabeprazole | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
361,
24,
379
]
],
[
[
361,
63,
1215
],
[
1215,
40,
379
]
],
[
[
361,
63,
660
],
[
660,
1,
379
]
],
[
[
361,
21,
28703
],
[
28703,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (Comp... |
DB00951 | DB09330 | 1,072 | 985 | [
"DDInter986",
"DDInter1352"
] | Isoniazid | Osimertinib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1072,
24,
985
]
],
[
[
1072,
63,
168
],
[
168,
23,
985
]
],
[
[
1072,
24,
1478
],
[
1478,
24,
985
]
],
[
[
1072,
63,
134
],
[
134,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor ... |
DB11691 | DB14723 | 1,499 | 159 | [
"DDInter1258",
"DDInter1026"
] | Naldemedine | Larotrectinib | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1499,
24,
159
]
],
[
[
1499,
63,
1135
],
[
1135,
23,
159
]
],
[
[
1499,
24,
1375
],
[
1375,
24,
159
]
],
[
[
1499,
63,
741
],
[
741,
... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamu... |
DB06212 | DB09049 | 165 | 1,135 | [
"DDInter1833",
"DDInter1261"
] | Tolvaptan | Naloxegol | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
165,
23,
1135
]
],
[
[
165,
24,
971
],
[
971,
62,
1135
]
],
[
[
165,
63,
1424
],
[
1424,
23,
1135
]
],
[
[
165,
24,
1618
],
[
1618,
... | [
[
[
"Tolvaptan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
[
... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine ma... |
DB00526 | DB01394 | 1,555 | 1,554 | [
"DDInter1355",
"DDInter431"
] | Oxaliplatin | Colchicine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Moderate | 1 | [
[
[
1555,
24,
1554
]
],
[
[
1555,
6,
10659
],
[
10659,
45,
1554
]
],
[
[
1555,
63,
367
],
[
367,
24,
1554
]
],
[
[
1555,
24,
458
],
[
458,... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colchicine"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A3"
],
[
"SLC22A3",
"{u} (Gene) is bound by {v} (Compoun... | Oxaliplatin (Compound) binds SLC22A3 (Gene) and SLC22A3 (Gene) is bound by Colchicine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Colch... |
DB00215 | DB04837 | 1,230 | 649 | [
"DDInter388",
"DDInter407"
] | Citalopram | Clofedanol | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1230,
24,
649
]
],
[
[
1230,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1230,
24,
832
],
[
832,
40,
649
]
],
[
[
1230,
25,
401
],
[
401,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB00060 | DB00445 | 912 | 322 | [
"DDInter947",
"DDInter655"
] | Interferon beta-1a | Epirubicin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
912,
24,
322
]
],
[
[
912,
24,
1247
],
[
1247,
62,
322
]
],
[
[
912,
63,
1648
],
[
1648,
24,
322
]
],
[
[
912,
24,
671
],
[
671,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethox... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken ... |
DB06616 | DB11057 | 594 | 720 | [
"DDInter224",
"DDInter1223"
] | Bosutinib | Mineral oil | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
594,
24,
720
]
],
[
[
594,
24,
927
],
[
927,
63,
720
]
],
[
[
594,
63,
1151
],
[
1151,
24,
720
]
],
[
[
594,
75,
1069
],
[
1069,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Suniti... |
DB00252 | DB11837 | 362 | 1,297 | [
"DDInter1460",
"DDInter1351"
] | Phenytoin | Osilodrostat | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
362,
25,
1297
]
],
[
[
362,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
362,
24,
112
],
[
112,
23,
1297
]
],
[
[
362,
25,
466
],
[
466,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Phenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may caus... |
DB00476 | DB00668 | 109 | 874 | [
"DDInter608",
"DDInter652"
] | Duloxetine | Epinephrine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
109,
24,
874
]
],
[
[
109,
63,
1636
],
[
1636,
1,
874
]
],
[
[
109,
24,
688
],
[
688,
63,
874
]
],
[
[
109,
6,
7950
],
[
7950,
4... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction tha... |
DB00661 | DB00687 | 122 | 870 | [
"DDInter1928",
"DDInter747"
] | Verapamil | Fludrocortisone | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
122,
24,
870
]
],
[
[
122,
24,
1220
],
[
1220,
40,
870
]
],
[
[
122,
63,
251
],
[
251,
40,
870
]
],
[
[
122,
21,
28936
],
[
28936,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Fludroc... |
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