drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB11837 | DB15982 | 1,297 | 1,339 | [
"DDInter1351",
"DDInter193"
] | Osilodrostat | Berotralstat | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
1297,
24,
1339
]
],
[
[
1297,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
1297,
62,
222
],
[
222,
23,
1339
]
],
[
[
1297,
24,
283
],
[
283,
... | [
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Osilodrostat may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sib... |
DB00264 | DB06703 | 88 | 619 | [
"DDInter1200",
"DDInter793"
] | Metoprolol | Gadobutrol | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to ot... | Moderate | 1 | [
[
[
88,
24,
619
]
],
[
[
88,
21,
28810
],
[
28810,
60,
619
]
],
[
[
88,
1,
819
],
[
819,
24,
619
]
],
[
[
88,
24,
1013
],
[
1013,
63... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobutrol"
]
],
[
[
"Metoprolol",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{... | Metoprolol (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Gadobutrol (Compound)
Metoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Gadobutrol
Metoprolol may cause... |
DB01030 | DB15965 | 869 | 1,330 | [
"DDInter1835",
"DDInter1270"
] | Topotecan | Naxitamab | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
869,
24,
1330
]
],
[
[
869,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
869,
63,
597
],
[
597,
24,
1330
]
],
[
[
869,
25,
770
],
[
770,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chlo... |
DB00108 | DB00242 | 1,066 | 1,064 | [
"DDInter1268",
"DDInter392"
] | Natalizumab | Cladribine | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Major | 2 | [
[
[
1066,
25,
1064
]
],
[
[
1066,
25,
1426
],
[
1426,
64,
1064
]
],
[
[
1066,
24,
1270
],
[
1270,
63,
1064
]
],
[
[
1066,
25,
869
],
[
869... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azacitidine"
],
[
"Azacitidine",
"{... | Natalizumab may lead to a major life threatening interaction when taken with Azacitidine and Azacitidine may lead to a major life threatening interaction when taken with Cladribine
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tube... |
DB00047 | DB01403 | 176 | 9 | [
"DDInter932",
"DDInter1175"
] | Insulin glargine | Methotrimeprazine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
176,
24,
9
]
],
[
[
176,
24,
1178
],
[
1178,
40,
9
]
],
[
[
176,
24,
401
],
[
401,
24,
9
]
],
[
[
176,
24,
1630
],
[
1630,
1,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluop... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause ... |
DB00283 | DB00472 | 701 | 758 | [
"DDInter395",
"DDInter758"
] | Clemastine | Fluoxetine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
701,
24,
758
]
],
[
[
701,
24,
358
],
[
358,
1,
758
]
],
[
[
701,
24,
109
],
[
109,
40,
758
]
],
[
[
701,
6,
12523
],
[
12523,
4... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Fluoxetine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compou... |
DB01133 | DB11126 | 1,104 | 900 | [
"DDInter1808",
"DDInter276"
] | Tiludronic acid | Calcium gluconate | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
1104,
24,
900
]
],
[
[
1104,
5,
11658
],
[
11658,
44,
1485
],
[
1485,
24,
900
]
],
[
[
1104,
6,
4139
],
[
4139,
45,
1485
],
[
1485,
... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Tiludronic acid",
"{u} (Compound) treats {v} (Disease)",
"Paget's disease of bone"
],
[
"Paget's disease o... | Tiludronic acid (Compound) treats Paget's disease of bone (Disease) and Paget's disease of bone (Disease) is treated by Alendronic acid (Compound) and Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Tiludronic acid (Compound) binds ATP6V1A (Gene) and ATP... |
DB00377 | DB11113 | 1,494 | 657 | [
"DDInter1382",
"DDInter307"
] | Palonosetron | Castor oil | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1494,
24,
657
]
],
[
[
1494,
24,
1079
],
[
1079,
24,
657
]
],
[
[
1494,
24,
927
],
[
927,
63,
657
]
],
[
[
1494,
25,
540
],
[
540,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and E... |
DB00586 | DB00722 | 1,512 | 743 | [
"DDInter537",
"DDInter1079"
] | Diclofenac | Lisinopril | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
1512,
24,
743
]
],
[
[
1512,
63,
610
],
[
610,
40,
743
]
],
[
[
1512,
24,
1058
],
[
1058,
40,
743
]
],
[
[
1512,
63,
1638
],
[
1638,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Moexipril and Moexipril (Compound) resembles Lisinopril (Compound)
Dicl... |
DB01206 | DB08895 | 37 | 976 | [
"DDInter1086",
"DDInter1825"
] | Lomustine | Tofacitinib | An alkylating agent of value against both hematologic malignancies and solid tumors. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
37,
25,
976
]
],
[
[
37,
63,
1461
],
[
1461,
23,
976
]
],
[
[
37,
24,
200
],
[
200,
63,
976
]
],
[
[
37,
24,
1430
],
[
1430,
24,... | [
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candi... |
DB00059 | DB00307 | 1,560 | 1,101 | [
"DDInter1404",
"DDInter202"
] | Pegaspargase | Bexarotene | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Major | 2 | [
[
[
1560,
25,
1101
]
],
[
[
1560,
24,
609
],
[
609,
62,
1101
]
],
[
[
1560,
24,
362
],
[
362,
23,
1101
]
],
[
[
1560,
24,
287
],
[
287,
... | [
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
[
"Cl... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin a... |
DB00635 | DB09381 | 1,573 | 192 | [
"DDInter1515",
"DDInter678"
] | Prednisone | Esterified estrogens | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1573,
24,
192
]
],
[
[
1573,
23,
771
],
[
771,
62,
192
]
],
[
[
1573,
24,
5
],
[
5,
24,
192
]
],
[
[
1573,
63,
1685
],
[
1685,
2... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Liragluti... |
DB01255 | DB11986 | 633 | 484 | [
"DDInter1078",
"DDInter648"
] | Lisdexamfetamine | Entrectinib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
633,
24,
484
]
],
[
[
633,
62,
112
],
[
112,
23,
484
]
],
[
[
633,
64,
222
],
[
222,
23,
484
]
],
[
[
633,
24,
774
],
[
774,
24,... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Lisdexamfetamine may lead to a major life threatening interaction when taken with Sibutramine and Sibut... |
DB00431 | DB09472 | 1,503 | 1,383 | [
"DDInter1072",
"DDInter1693"
] | Lindane | Sodium sulfate | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1503,
24,
1383
]
],
[
[
1503,
24,
678
],
[
678,
24,
1383
]
],
[
[
1503,
63,
1466
],
[
1466,
24,
1383
]
],
[
[
1503,
25,
593
],
[
593,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine and Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamine a... |
DB00501 | DB01142 | 752 | 1,264 | [
"DDInter380",
"DDInter593"
] | Cimetidine | Doxepin | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
752,
24,
1264
]
],
[
[
752,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
752,
21,
28898
],
[
28898,
60,
1264
]
],
[
[
752,
23,
1438
],
[
1438,... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Cimetidine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxepin (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Estradiol and Estradiol... |
DB00186 | DB01612 | 905 | 1,637 | [
"DDInter1092",
"DDInter92"
] | Lorazepam | Amyl Nitrite | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
905,
24,
1637
]
],
[
[
905,
40,
1216
],
[
1216,
24,
1637
]
],
[
[
905,
25,
475
],
[
475,
24,
1637
]
],
[
[
905,
24,
401
],
[
401,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Lorazepam",
"{u} (Compound) resembles {v} (Compound)",
"Flurazepam"
],
[
"Flurazepam",
"{u} may cause a moderat... | Lorazepam (Compound) resembles Flurazepam (Compound) and Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Lorazepam may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate disease... |
DB01098 | DB12010 | 14 | 214 | [
"DDInter1622",
"DDInter785"
] | Rosuvastatin | Fostamatinib | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
14,
24,
214
]
],
[
[
14,
24,
973
],
[
973,
24,
214
]
],
[
[
14,
63,
10
],
[
10,
24,
214
]
],
[
[
14,
62,
600
],
[
600,
24,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dap... |
DB00631 | DB06718 | 372 | 1,687 | [
"DDInter405",
"DDInter1709"
] | Clofarabine | Stanozolol | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
372,
24,
1687
]
],
[
[
372,
24,
1546
],
[
1546,
1,
1687
]
],
[
[
372,
63,
1561
],
[
1561,
40,
1687
]
],
[
[
372,
24,
984
],
[
984,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resembles ... |
DB00850 | DB01041 | 1,630 | 770 | [
"DDInter1432",
"DDInter1789"
] | Perphenazine | Thalidomide | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1630,
24,
770
]
],
[
[
1630,
6,
10215
],
[
10215,
45,
770
]
],
[
[
1630,
7,
7669
],
[
7669,
46,
770
]
],
[
[
1630,
18,
20113
],
[
2011... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Perphenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Comp... | Perphenazine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Thalidomide (Compound)
Perphenazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Perphenazine (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Thalidomide (Compound)
Perph... |
DB10672 | DB12364 | 297 | 1,421 | [
"DDInter417",
"DDInter200"
] | Clove | Betrixaban | Clove allergenic extract is used in allergenic testing. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Minor | 0 | [
[
[
297,
23,
1421
]
],
[
[
297,
62,
477
],
[
477,
25,
1421
]
],
[
[
297,
23,
235
],
[
235,
25,
1421
]
],
[
[
297,
62,
477
],
[
477,
... | [
[
[
"Clove",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Betrixaban"
]
],
[
[
"Clove",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cilostazol"
],
[
"Cilostazo... | Clove may cause a minor interaction that can limit clinical effects when taken with Cilostazol and Cilostazol may lead to a major life threatening interaction when taken with Betrixaban
Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin and Desirudin may lead to a major life t... |
DB01190 | DB01320 | 568 | 651 | [
"DDInter398",
"DDInter783"
] | Clindamycin | Fosphenytoin | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
568,
24,
651
]
],
[
[
568,
63,
362
],
[
362,
1,
651
]
],
[
[
568,
6,
8374
],
[
8374,
45,
651
]
],
[
[
568,
21,
28660
],
[
28660,
... | [
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Clindamycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Clindamycin (Compound) causes Pelvic pain (Side Effect) and Pe... |
DB00078 | DB00472 | 1,172 | 758 | [
"DDInter898",
"DDInter758"
] | Ibritumomab tiuxetan | Fluoxetine | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
1172,
24,
758
]
],
[
[
1172,
24,
109
],
[
109,
40,
758
]
],
[
[
1172,
64,
20
],
[
20,
24,
758
]
],
[
[
1172,
25,
802
],
[
802,
6... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxet... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compound)
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a moderate interaction t... |
DB00773 | DB01208 | 896 | 945 | [
"DDInter702",
"DDInter1705"
] | Etoposide | Sparfloxacin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
896,
23,
945
]
],
[
[
896,
23,
739
],
[
739,
1,
945
]
],
[
[
896,
62,
1176
],
[
1176,
1,
945
]
],
[
[
896,
6,
4973
],
[
4973,
45... | [
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Etoposide may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Etoposide may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Comp... |
DB00295 | DB00690 | 475 | 1,216 | [
"DDInter1244",
"DDInter762"
] | Morphine | Flurazepam | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A benzodiazepine derivative used mainly as a hypnotic. | Major | 2 | [
[
[
475,
25,
1216
]
],
[
[
475,
25,
1418
],
[
1418,
1,
1216
]
],
[
[
475,
24,
1382
],
[
1382,
1,
1216
]
],
[
[
475,
25,
481
],
[
481,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flurazepam"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Estazolam"
],
[
"Estazolam",
"{u} (Compou... | Morphine may lead to a major life threatening interaction when taken with Estazolam and Estazolam (Compound) resembles Flurazepam (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Flurazepam (Compound)
Morphine may lead to a ... |
DB00352 | DB11363 | 482 | 1,276 | [
"DDInter1814",
"DDInter39"
] | Tioguanine | Alectinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
482,
24,
1276
]
],
[
[
482,
63,
305
],
[
305,
24,
1276
]
],
[
[
482,
25,
1011
],
[
1011,
24,
1276
]
],
[
[
482,
24,
850
],
[
850,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia col... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Tioguanine may lead to a major life threatening interaction when taken with... |
DB01033 | DB11601 | 328 | 1,270 | [
"DDInter1156",
"DDInter1889"
] | Mercaptopurine | Tuberculin purified protein derivative | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
328,
24,
1270
]
],
[
[
328,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
328,
63,
869
],
[
869,
24,
1270
]
],
[
[
328,
64,
1064
],
[
1064,
... | [
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Mercaptopurine may cause a moderate interaction that could exacerbate diseases... |
DB00574 | DB11166 | 121 | 18 | [
"DDInter717",
"DDInter104"
] | Fenfluramine | Antithrombin Alfa | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Moderate | 1 | [
[
[
121,
24,
18
]
],
[
[
121,
24,
714
],
[
714,
24,
18
]
],
[
[
121,
25,
1039
],
[
1039,
24,
18
]
],
[
[
121,
63,
1061
],
[
1061,
24... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Antithrombin Alfa
Fenfluramine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dex
Fenfl... |
DB00812 | DB11837 | 998 | 1,297 | [
"DDInter1451",
"DDInter1351"
] | Phenylbutazone | Osilodrostat | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
998,
24,
1297
]
],
[
[
998,
24,
1135
],
[
1135,
23,
1297
]
],
[
[
998,
24,
466
],
[
466,
62,
1297
]
],
[
[
998,
24,
1320
],
[
1320,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide an... |
DB00816 | DB01238 | 1,674 | 673 | [
"DDInter1346",
"DDInter118"
] | Orciprenaline | Aripiprazole | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
1674,
24,
673
]
],
[
[
1674,
63,
827
],
[
827,
40,
673
]
],
[
[
1674,
24,
1630
],
[
1630,
1,
673
]
],
[
[
1674,
21,
28763
],
[
28763,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole... |
DB00352 | DB00697 | 482 | 876 | [
"DDInter1814",
"DDInter1821"
] | Tioguanine | Tizanidine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
482,
24,
876
]
],
[
[
482,
21,
28826
],
[
28826,
60,
876
]
],
[
[
482,
25,
770
],
[
770,
63,
876
]
],
[
[
482,
24,
1374
],
[
1374,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is caused... | Tioguanine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Tizanidine (Compound)
Tioguanine may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Tizanidine
Tioguanine ... |
DB08918 | DB09065 | 41 | 760 | [
"DDInter1059",
"DDInter424"
] | Levomilnacipran | Cobicistat | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
41,
25,
760
]
],
[
[
41,
64,
609
],
[
609,
24,
760
]
],
[
[
41,
24,
1421
],
[
1421,
63,
760
]
],
[
[
41,
63,
1047
],
[
1047,
24,... | [
[
[
"Levomilnacipran",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Levomilnacipran",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromy... | Levomilnacipran may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Bet... |
DB00802 | DB09241 | 1,322 | 1,629 | [
"DDInter43",
"DDInter1186"
] | Alfentanil | Methylene blue | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1322,
25,
1629
]
],
[
[
1322,
24,
1311
],
[
1311,
24,
1629
]
],
[
[
1322,
63,
73
],
[
73,
25,
1629
]
],
[
[
1322,
40,
411
],
[
411,
... | [
[
[
"Alfentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"Me... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Phentermi... |
DB00468 | DB00818 | 1,424 | 898 | [
"DDInter1557",
"DDInter1538"
] | Quinine | Propofol | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
1424,
24,
898
]
],
[
[
1424,
6,
12523
],
[
12523,
45,
898
]
],
[
[
1424,
21,
28841
],
[
28841,
60,
898
]
],
[
[
1424,
63,
1031
],
[
10... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"... | Quinine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propofol (Compound)
Quinine (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Propofol (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophyll... |
DB00570 | DB01234 | 147 | 1,220 | [
"DDInter1936",
"DDInter513"
] | Vinblastine | Dexamethasone | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
147,
24,
1220
]
],
[
[
147,
5,
11555
],
[
11555,
44,
1220
]
],
[
[
147,
6,
10083
],
[
10083,
45,
1220
]
],
[
[
147,
18,
5142
],
[
5142... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Vinblastine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (D... | Vinblastine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dexamethasone (Compound)
Vinblastine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Dexamethasone (Compound)
Vinblastine (Compound) downregulates ICAM3 (Gene) and ICAM3 (Gene) is upregulated by Dexame... |
DB00530 | DB00992 | 1,195 | 842 | [
"DDInter667",
"DDInter1182"
] | Erlotinib | Methyl aminolevulinate (topical) | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
1195,
24,
842
]
],
[
[
1195,
21,
29124
],
[
29124,
60,
842
]
],
[
[
1195,
24,
1622
],
[
1622,
24,
842
]
],
[
[
1195,
24,
943
],
[
943,... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Erlotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Rash pustular"
],
[
"Rash pustular",
"{u} (Si... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Erlotinib (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Methyl aminolevulinate (Compound)
Erlotinib may cause a moderate interaction that could exacerbate disease... |
DB00976 | DB05773 | 1,056 | 1,047 | [
"DDInter1758",
"DDInter1848"
] | Telithromycin | Trastuzumab emtansine | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1056,
24,
1047
]
],
[
[
1056,
24,
310
],
[
310,
63,
1047
]
],
[
[
1056,
64,
467
],
[
467,
24,
1047
]
],
[
[
1056,
25,
1593
],
[
1593,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxe... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Telithromycin may lead to a major life threatening interaction when taken with Simvastatin and S... |
DB00454 | DB01233 | 1,349 | 1,311 | [
"DDInter1150",
"DDInter1197"
] | Meperidine | Metoclopramide | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1349,
24,
1311
]
],
[
[
1349,
6,
12523
],
[
12523,
45,
1311
]
],
[
[
1349,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1349,
24,
1383
],
[
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Meperidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Meperidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Meperidine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Sodium su... |
DB00694 | DB11828 | 51 | 1,406 | [
"DDInter485",
"DDInter1281"
] | Daunorubicin | Neratinib | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
51,
24,
1406
]
],
[
[
51,
24,
392
],
[
392,
24,
1406
]
],
[
[
51,
25,
1510
],
[
1510,
24,
1406
]
],
[
[
51,
63,
134
],
[
134,
24... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Daunorubicin may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may... |
DB00773 | DB01254 | 896 | 1,213 | [
"DDInter702",
"DDInter484"
] | Etoposide | Dasatinib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
896,
24,
1213
]
],
[
[
896,
5,
11555
],
[
11555,
44,
1213
]
],
[
[
896,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
896,
7,
7972
],
[
7972,... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Etoposide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) ... | Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dasatinib (Compound)
Etoposide (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Etoposide (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Dasatinib (Compound)... |
DB00704 | DB14761 | 267 | 242 | [
"DDInter1263",
"DDInter1578"
] | Naltrexone | Remdesivir | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
267,
24,
242
]
],
[
[
267,
24,
1130
],
[
1130,
24,
242
]
],
[
[
267,
63,
467
],
[
467,
24,
242
]
],
[
[
267,
25,
1377
],
[
1377,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and S... |
DB00358 | DB11853 | 1,010 | 230 | [
"DDInter1140",
"DDInter1577"
] | Mefloquine | Relugolix | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
1010,
24,
230
]
],
[
[
1010,
24,
129
],
[
129,
23,
230
]
],
[
[
1010,
23,
112
],
[
112,
23,
230
]
],
[
[
1010,
63,
1101
],
[
1101,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metr... |
DB00073 | DB15762 | 1,394 | 725 | [
"DDInter1608",
"DDInter1644"
] | Rituximab | Satralizumab | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Major | 2 | [
[
[
1394,
25,
725
]
],
[
[
1394,
23,
1193
],
[
1193,
23,
725
]
],
[
[
1394,
24,
1362
],
[
1362,
24,
725
]
],
[
[
1394,
25,
1066
],
[
1066,... | [
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
]
],
[
[
"Rituximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc glu... | Rituximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Satralizumab
Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olap... |
DB03404 | DB08896 | 765 | 292 | [
"DDInter855",
"DDInter1576"
] | Hemin | Regorafenib | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
765,
24,
292
]
],
[
[
765,
64,
697
],
[
697,
24,
292
]
],
[
[
765,
63,
383
],
[
383,
24,
292
]
],
[
[
765,
63,
553
],
[
553,
25,... | [
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Hemin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenobarbital"
],
[
"Phenobarbital",
... | Hemin may lead to a major life threatening interaction when taken with Phenobarbital and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib
Hemin may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polys... |
DB00204 | DB00398 | 228 | 79 | [
"DDInter580",
"DDInter1702"
] | Dofetilide | Sorafenib | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Major | 2 | [
[
[
228,
25,
79
]
],
[
[
228,
6,
8374
],
[
8374,
45,
79
]
],
[
[
228,
18,
18226
],
[
18226,
46,
79
]
],
[
[
228,
21,
28722
],
[
28722,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sorafenib"
]
],
[
[
"Dofetilide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Sorafeni... | Dofetilide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sorafenib (Compound)
Dofetilide (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is upregulated by Sorafenib (Compound)
Dofetilide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Sorafenib (Compound)
Dofetilide ma... |
DB00316 | DB08881 | 474 | 868 | [
"DDInter14",
"DDInter1925"
] | Acetaminophen | Vemurafenib | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
474,
24,
868
]
],
[
[
474,
6,
8374
],
[
8374,
45,
868
]
],
[
[
474,
18,
2852
],
[
2852,
57,
868
]
],
[
[
474,
21,
28847
],
[
28847,
... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Acetaminophen",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Acetaminophen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Acetaminophen (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Vemurafenib (Compound)
Acetaminophen (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemuraf... |
DB00649 | DB01083 | 231 | 1,142 | [
"DDInter1710",
"DDInter1348"
] | Stavudine | Orlistat | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Moderate | 1 | [
[
[
231,
24,
1142
]
],
[
[
231,
18,
8397
],
[
8397,
57,
1142
]
],
[
[
231,
21,
28645
],
[
28645,
60,
1142
]
],
[
[
231,
1,
1477
],
[
1477,... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
]
],
[
[
"Stavudine",
"{u} (Compound) downregulates {v} (Gene)",
"PPP2R3C"
],
[
"PPP2R3C",
"{u} (Gene) is downregulated by {v... | Stavudine (Compound) downregulates PPP2R3C (Gene) and PPP2R3C (Gene) is downregulated by Orlistat (Compound)
Stavudine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Orlistat (Compound)
Stavudine (Compound) resembles Telbivudine (Compound) and Telbivudine may cause a moderate interaction tha... |
DB00794 | DB12015 | 759 | 1,033 | [
"DDInter1521",
"DDInter53"
] | Primidone | Alpelisib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Major | 2 | [
[
[
759,
25,
1033
]
],
[
[
759,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
759,
24,
738
],
[
738,
24,
1033
]
],
[
[
759,
25,
951
],
[
951,
... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alpelisib"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ca... | Primidone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderat... |
DB00341 | DB00754 | 1,242 | 157 | [
"DDInter343",
"DDInter696"
] | Cetirizine | Ethotoin | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
1242,
24,
157
]
],
[
[
1242,
24,
759
],
[
759,
40,
157
]
],
[
[
1242,
24,
499
],
[
499,
1,
157
]
],
[
[
1242,
21,
28763
],
[
28763,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound)
Ce... |
DB00736 | DB09297 | 660 | 1,553 | [
"DDInter676",
"DDInter1395"
] | Esomeprazole | Paritaprevir | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common ... | Moderate | 1 | [
[
[
660,
24,
1553
]
],
[
[
660,
64,
663
],
[
663,
24,
1501
],
[
1501,
63,
1553
]
],
[
[
660,
63,
1463
],
[
1463,
24,
1501
],
[
1501,
63,... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paritaprevir"
]
],
[
[
"Esomeprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
],
[
"Me... | Esomeprazole may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib and Enasidenib may cause a moderate interaction that could exacerbate diseases when taken with Paritaprevir
Esomeprazole ... |
DB00424 | DB01224 | 19 | 623 | [
"DDInter896",
"DDInter1553"
] | Hyoscyamine | Quetiapine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
19,
24,
623
]
],
[
[
19,
63,
695
],
[
695,
1,
623
]
],
[
[
19,
24,
87
],
[
87,
1,
623
]
],
[
[
19,
6,
7992
],
[
7992,
45,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Quetiapine (Compound)
Hy... |
DB00564 | DB00912 | 1,236 | 473 | [
"DDInter293",
"DDInter1581"
] | Carbamazepine | Repaglinide | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1236,
24,
473
]
],
[
[
1236,
6,
3486
],
[
3486,
45,
473
]
],
[
[
1236,
21,
28873
],
[
28873,
60,
473
]
],
[
[
1236,
25,
609
],
[
609,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Comp... | Carbamazepine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Repaglinide (Compound)
Carbamazepine (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Carbamazepine may lead to a major life threatening interaction when taken with Clarithromycin an... |
DB00607 | DB06603 | 1,249 | 39 | [
"DDInter1256",
"DDInter1387"
] | Nafcillin | Panobinostat | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
1249,
24,
39
]
],
[
[
1249,
24,
578
],
[
578,
63,
39
]
],
[
[
1249,
24,
1419
],
[
1419,
24,
39
]
],
[
[
1249,
63,
597
],
[
597,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib... |
DB00489 | DB11093 | 17 | 636 | [
"DDInter1704",
"DDInter273"
] | Sotalol | Calcium citrate | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
17,
24,
636
]
],
[
[
17,
1,
88
],
[
88,
24,
636
]
],
[
[
17,
62,
542
],
[
542,
24,
636
]
],
[
[
17,
23,
115
],
[
115,
25,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Sotalol",
"{u} (Compound) resembles {v} (Compound)",
"Metoprolol"
],
[
"Metoprolol",
"{u} may cause a moderate... | Sotalol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Sotalol may cause a minor interaction that can limit clinical effects when taken with Levothyroxine and Levothyroxine may cause a moderate interaction that co... |
DB00719 | DB06077 | 1,219 | 879 | [
"DDInter149",
"DDInter1102"
] | Azatadine | Lumateperone | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1219,
24,
879
]
],
[
[
1219,
24,
407
],
[
407,
63,
879
]
],
[
[
1219,
24,
1511
],
[
1511,
24,
879
]
],
[
[
1219,
63,
352
],
[
352,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may... |
DB00209 | DB01359 | 352 | 729 | [
"DDInter1886",
"DDInter1417"
] | Trospium | Penbutolol | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
352,
24,
729
]
],
[
[
352,
24,
461
],
[
461,
1,
729
]
],
[
[
352,
24,
699
],
[
699,
40,
729
]
],
[
[
352,
21,
28762
],
[
28762,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
"Ti... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Trospium (Compou... |
DB00086 | DB01050 | 1,167 | 848 | [
"DDInter1712",
"DDInter900"
] | Streptokinase | Ibuprofen | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1167,
24,
848
]
],
[
[
1167,
23,
297
],
[
297,
62,
848
]
],
[
[
1167,
24,
831
],
[
831,
24,
848
]
],
[
[
1167,
64,
1578
],
[
1578,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Streptokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
... | Streptokinase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin ... |
DB00916 | DB01100 | 112 | 1,568 | [
"DDInter1202",
"DDInter1470"
] | Metronidazole | Pimozide | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Minor | 0 | [
[
[
112,
23,
1568
]
],
[
[
112,
62,
78
],
[
78,
40,
1568
]
],
[
[
112,
62,
1557
],
[
1557,
25,
1568
]
],
[
[
112,
6,
8374
],
[
8374,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pimozide"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Droperidol"
],
[
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Astemizole and Astemizole may lead to a major life threatening intera... |
DB00705 | DB12010 | 441 | 214 | [
"DDInter496",
"DDInter785"
] | Delavirdine | Fostamatinib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
441,
25,
214
]
],
[
[
441,
25,
976
],
[
976,
24,
214
]
],
[
[
441,
63,
723
],
[
723,
24,
214
]
],
[
[
441,
24,
1144
],
[
1144,
2... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
... | Delavirdine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ... |
DB01208 | DB11248 | 945 | 1,193 | [
"DDInter1705",
"DDInter1965"
] | Sparfloxacin | Zinc gluconate | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
945,
24,
1193
]
],
[
[
945,
63,
1096
],
[
1096,
23,
1193
]
],
[
[
945,
24,
1596
],
[
1596,
23,
1193
]
],
[
[
945,
64,
167
],
[
167,
... | [
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with I... |
DB02701 | DB08827 | 1,632 | 990 | [
"DDInter1289",
"DDInter1085"
] | Nicotinamide | Lomitapide | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1632,
25,
990
]
],
[
[
1632,
63,
322
],
[
322,
24,
990
]
],
[
[
1632,
24,
761
],
[
761,
24,
990
]
],
[
[
1632,
24,
1281
],
[
1281,
... | [
[
[
"Nicotinamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
"Epirub... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and S... |
DB00515 | DB06414 | 589 | 655 | [
"DDInter387",
"DDInter703"
] | Cisplatin | Etravirine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
589,
24,
655
]
],
[
[
589,
6,
4973
],
[
4973,
45,
655
]
],
[
[
589,
21,
28723
],
[
28723,
60,
655
]
],
[
[
589,
63,
168
],
[
168,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Cisplatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Cisplatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Cisplatin (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Etravirine (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bor... |
DB00222 | DB01365 | 245 | 280 | [
"DDInter825",
"DDInter1151"
] | Glimepiride | Mephentermine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
245,
24,
280
]
],
[
[
245,
24,
551
],
[
551,
1,
280
]
],
[
[
245,
24,
22
],
[
22,
40,
280
]
],
[
[
245,
24,
52
],
[
52,
63,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Mephentermine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine (Compound) resembles Mephentermine (Comp... |
DB00580 | DB00992 | 311 | 842 | [
"DDInter1910",
"DDInter1182"
] | Valdecoxib | Methyl aminolevulinate (topical) | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
311,
24,
842
]
],
[
[
311,
24,
1274
],
[
1274,
24,
842
]
],
[
[
311,
63,
663
],
[
663,
24,
842
]
],
[
[
311,
24,
1040
],
[
1040,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Methy... |
DB00023 | DB06403 | 305 | 1,204 | [
"DDInter127",
"DDInter62"
] | Asparaginase Escherichia coli | Ambrisentan | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Moderate | 1 | [
[
[
305,
24,
1204
]
],
[
[
305,
24,
600
],
[
600,
23,
1204
]
],
[
[
305,
24,
868
],
[
868,
63,
1204
]
],
[
[
305,
24,
478
],
[
478,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambrisentan"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ambrisentan
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate disease... |
DB00380 | DB10316 | 145 | 334 | [
"DDInter522",
"DDInter1248"
] | Dexrazoxane | Mumps virus strain B level jeryl lynn live antigen | An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug ... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
145,
25,
334
]
],
[
[
145,
24,
713
],
[
713,
25,
334
]
],
[
[
145,
6,
3930
],
[
3930,
45,
51
],
[
51,
25,
334
]
],
[
[
145,
24,
... | [
[
[
"Dexrazoxane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Dexrazoxane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Dexrazoxane may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Dexrazoxane (Compound) binds TOP2B (Gene) and TOP2B (Gene) is bound by D... |
DB06186 | DB12834 | 1,439 | 148 | [
"DDInter969",
"DDInter1649"
] | Ipilimumab | Secnidazole | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1439,
24,
148
]
],
[
[
1439,
24,
1593
],
[
1593,
24,
148
]
],
[
[
1439,
63,
1191
],
[
1191,
24,
148
]
],
[
[
1439,
25,
1510
],
[
1510,... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodop... |
DB00804 | DB01193 | 1,507 | 819 | [
"DDInter543",
"DDInter12"
] | Dicyclomine | Acebutolol | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1507,
24,
819
]
],
[
[
1507,
24,
887
],
[
887,
1,
819
]
],
[
[
1507,
63,
1121
],
[
1121,
1,
819
]
],
[
[
1507,
21,
28863
],
[
28863,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Acebutolol (Compound)
Di... |
DB00191 | DB00206 | 73 | 1,245 | [
"DDInter1447",
"DDInter1582"
] | Phentermine | Reserpine | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Moderate | 1 | [
[
[
73,
24,
1245
]
],
[
[
73,
24,
1340
],
[
1340,
1,
1245
]
],
[
[
73,
21,
28787
],
[
28787,
60,
1245
]
],
[
[
73,
35,
22
],
[
22,
6... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpine"
]
],
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
],
[
... | Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Deserpidine and Deserpidine (Compound) resembles Reserpine (Compound)
Phentermine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Reserpine (Compound)
Phentermine (Compound) resembles Ephedri... |
DB00582 | DB09268 | 1,622 | 1,662 | [
"DDInter1946",
"DDInter1464"
] | Voriconazole | Picosulfuric acid | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1622,
24,
1662
]
],
[
[
1622,
25,
484
],
[
484,
63,
1662
]
],
[
[
1622,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
1622,
25,
1618
],
[
1618... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
... | Voriconazole may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib... |
DB00371 | DB00427 | 1,050 | 1,233 | [
"DDInter1154",
"DDInter1879"
] | Meprobamate | Triprolidine | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
1050,
24,
1233
]
],
[
[
1050,
24,
104
],
[
104,
63,
1233
]
],
[
[
1050,
63,
1242
],
[
1242,
24,
1233
]
],
[
[
1050,
24,
999
],
[
999,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine an... |
DB01169 | DB01263 | 57 | 859 | [
"DDInter120",
"DDInter1494"
] | Arsenic trioxide | Posaconazole | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Major | 2 | [
[
[
57,
25,
859
]
],
[
[
57,
6,
4973
],
[
4973,
45,
859
]
],
[
[
57,
62,
112
],
[
112,
23,
859
]
],
[
[
57,
24,
286
],
[
286,
63,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Posaconazole"
]
],
[
[
"Arsenic trioxide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Arsenic trioxide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Posaconazole
Ar... |
DB12130 | DB12332 | 1,017 | 1,619 | [
"DDInter1094",
"DDInter1626"
] | Lorlatinib | Rucaparib | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1017,
24,
1619
]
],
[
[
1017,
63,
222
],
[
222,
23,
1619
]
],
[
[
1017,
64,
307
],
[
307,
23,
1619
]
],
[
[
1017,
62,
271
],
[
271,
... | [
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Lorlatinib may lead to a major life threatening interaction when taken with Modafinil and Modafinil may cause a m... |
DB00207 | DB00637 | 1,570 | 1,557 | [
"DDInter157",
"DDInter128"
] | Azithromycin | Astemizole | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
1570,
24,
1557
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
1557
]
],
[
[
1570,
18,
4884
],
[
4884,
57,
1557
]
],
[
[
1570,
23,
112
],
[
112,... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Astemizole (Compound)
Azithromycin (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Astemizole (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
DB01097 | DB08871 | 1,377 | 36 | [
"DDInter1033",
"DDInter666"
] | Leflunomide | Eribulin | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1377,
25,
36
]
],
[
[
1377,
64,
1279
],
[
1279,
23,
36
]
],
[
[
1377,
24,
221
],
[
221,
63,
36
]
],
[
[
1377,
63,
563
],
[
563,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Emtricitabine"
],
[
"Emtricitabine",
... | Leflunomide may lead to a major life threatening interaction when taken with Emtricitabine and Emtricitabine may cause a minor interaction that can limit clinical effects when taken with Eribulin
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (forma... |
DB00197 | DB00909 | 1,324 | 306 | [
"DDInter1881",
"DDInter1971"
] | Troglitazone | Zonisamide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Moderate | 1 | [
[
[
1324,
24,
306
]
],
[
[
1324,
24,
159
],
[
159,
63,
306
]
],
[
[
1324,
24,
506
],
[
506,
24,
306
]
],
[
[
1324,
23,
1101
],
[
1101,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zonisamide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Zonisamide
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Dextrometho... |
DB00477 | DB00855 | 216 | 213 | [
"DDInter363",
"DDInter72"
] | Chlorpromazine | Aminolevulinic acid | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
216,
25,
213
]
],
[
[
216,
7,
18134
],
[
18134,
46,
213
]
],
[
[
216,
18,
17504
],
[
17504,
57,
213
]
],
[
[
216,
21,
28766
],
[
28766... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) upregulates {v} (Gene)",
"POLD4"
],
[
"POLD4",
"{u} (Gene) is upregulated by {v} ... | Chlorpromazine (Compound) upregulates POLD4 (Gene) and POLD4 (Gene) is upregulated by Aminolevulinic acid (Compound)
Chlorpromazine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregulated by Aminolevulinic acid (Compound)
Chlorpromazine (Compound) causes Hypotension (Side Effect) and Hypotension (Si... |
DB00056 | DB00095 | 816 | 66 | [
"DDInter814",
"DDInter623"
] | Gemtuzumab ozogamicin | Efalizumab | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Moderate | 1 | [
[
[
816,
24,
66
]
],
[
[
816,
24,
151
],
[
151,
63,
66
]
],
[
[
816,
25,
375
],
[
375,
63,
66
]
],
[
[
816,
25,
581
],
[
581,
24,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influ... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) and Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) may cause a moderate interaction that coul... |
DB01110 | DB09074 | 86 | 1,362 | [
"DDInter1209",
"DDInter1327"
] | Miconazole | Olaparib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
86,
24,
1362
]
],
[
[
86,
63,
576
],
[
576,
24,
1362
]
],
[
[
86,
24,
1478
],
[
1478,
24,
1362
]
],
[
[
86,
24,
214
],
[
214,
63... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methadone"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor m... |
DB01143 | DB12865 | 923 | 922 | [
"DDInter65",
"DDInter688"
] | Amifostine | Etelcalcetide | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017. | Major | 2 | [
[
[
923,
25,
922
]
],
[
[
923,
63,
1028
],
[
1028,
25,
922
]
],
[
[
923,
63,
1028
],
[
1028,
24,
589
],
[
589,
25,
922
]
],
[
[
923,
... | [
[
[
"Amifostine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etelcalcetide"
]
],
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Torasemide"
],
[
"Torasem... | Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Torasemide and Torasemide may lead to a major life threatening interaction when taken with Etelcalcetide
Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Torasemide and Torasemide may cau... |
DB01211 | DB01254 | 609 | 1,213 | [
"DDInter393",
"DDInter484"
] | Clarithromycin | Dasatinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
609,
25,
1213
]
],
[
[
609,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
609,
7,
3466
],
[
3466,
46,
1213
]
],
[
[
609,
18,
8733
],
[
8733,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Da... | Clarithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Clarithromycin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Dasatinib (Compound)
Clarithromycin (Compound) downregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Dasatinib (Compound)
Clarithro... |
DB00909 | DB01128 | 306 | 918 | [
"DDInter1971",
"DDInter204"
] | Zonisamide | Bicalutamide | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
306,
24,
918
]
],
[
[
306,
24,
129
],
[
129,
40,
918
]
],
[
[
306,
6,
8374
],
[
8374,
45,
918
]
],
[
[
306,
21,
29666
],
[
29666,
... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Zonisamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Zonisamide (Compound) causes Melaena (Side Effect) and Mel... |
DB00582 | DB09065 | 1,622 | 760 | [
"DDInter1946",
"DDInter424"
] | Voriconazole | Cobicistat | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1622,
24,
760
]
],
[
[
1622,
64,
1101
],
[
1101,
23,
760
]
],
[
[
1622,
24,
1374
],
[
1374,
23,
760
]
],
[
[
1622,
24,
1041
],
[
1041,... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Voriconazole may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may ca... |
DB00862 | DB08899 | 1,005 | 129 | [
"DDInter1918",
"DDInter649"
] | Vardenafil | Enzalutamide | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1005,
24,
129
]
],
[
[
1005,
24,
918
],
[
918,
1,
129
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1005,
21,
28703
],
[
28703,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Vardenafil (Compound) causes Pruritus (Side Effect) and Pr... |
DB01320 | DB11828 | 651 | 1,406 | [
"DDInter783",
"DDInter1281"
] | Fosphenytoin | Neratinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
651,
25,
1406
]
],
[
[
651,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
651,
63,
392
],
[
392,
24,
1406
]
],
[
[
651,
25,
1510
],
[
1510,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ... | Fosphenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a m... |
DB09020 | DB11730 | 28 | 351 | [
"DDInter212",
"DDInter1588"
] | Bisacodyl | Ribociclib | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
28,
24,
351
]
],
[
[
28,
63,
355
],
[
355,
24,
351
]
],
[
[
28,
24,
286
],
[
286,
24,
351
]
],
[
[
28,
63,
129
],
[
129,
25,
... | [
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
],
[
... | Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and M... |
DB01234 | DB06616 | 1,220 | 594 | [
"DDInter513",
"DDInter224"
] | Dexamethasone | Bosutinib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1220,
25,
594
]
],
[
[
1220,
63,
883
],
[
883,
1,
594
]
],
[
[
1220,
7,
8922
],
[
8922,
45,
594
]
],
[
[
1220,
6,
8374
],
[
8374,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefiti... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Dexamethasone (Compound) upregulates SIK1 (Gene) and SIK1 (Gene) is bound by Bosutinib (Compound)
Dexamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene)... |
DB00812 | DB08820 | 998 | 1,478 | [
"DDInter1451",
"DDInter997"
] | Phenylbutazone | Ivacaftor | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
998,
24,
1478
]
],
[
[
998,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
998,
40,
307
],
[
307,
23,
1478
]
],
[
[
998,
24,
1135
],
[
1135,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Phenylbutazone (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Ivacaftor
Phenylbutazone may cause a moderate interaction that could exace... |
DB01224 | DB09268 | 623 | 1,662 | [
"DDInter1553",
"DDInter1464"
] | Quetiapine | Picosulfuric acid | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
623,
24,
1662
]
],
[
[
623,
24,
484
],
[
484,
63,
1662
]
],
[
[
623,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
623,
63,
597
],
[
597,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Quetiapine may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantin... |
DB00370 | DB00836 | 1,251 | 543 | [
"DDInter1230",
"DDInter1088"
] | Mirtazapine | Loperamide | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
1251,
24,
543
]
],
[
[
1251,
24,
649
],
[
649,
1,
543
]
],
[
[
1251,
24,
888
],
[
888,
24,
543
]
],
[
[
1251,
63,
1242
],
[
1242,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could... |
DB00656 | DB01268 | 827 | 1,151 | [
"DDInter1851",
"DDInter1731"
] | Trazodone | Sunitinib | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
827,
24,
1151
]
],
[
[
827,
24,
1311
],
[
1311,
1,
1151
]
],
[
[
827,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
827,
21,
29170
],
[
29170,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Trazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Trazodone (Compound) causes Cardiac failure congestive (Side Eff... |
DB00370 | DB12245 | 1,251 | 823 | [
"DDInter1230",
"DDInter1863"
] | Mirtazapine | Triclabendazole | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1251,
24,
823
]
],
[
[
1251,
23,
112
],
[
112,
23,
823
]
],
[
[
1251,
63,
1010
],
[
1010,
24,
823
]
],
[
[
1251,
24,
28
],
[
28,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Mirtazapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB00539 | DB04938 | 11 | 1,423 | [
"DDInter1837",
"DDInter1353"
] | Toremifene | Ospemifene | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Moderate | 1 | [
[
[
11,
35,
1423
]
],
[
[
11,
25,
485
],
[
485,
40,
1423
]
],
[
[
11,
1,
11234
],
[
11234,
1,
1423
]
],
[
[
11,
1,
596
],
[
596,
40,... | [
[
[
"Toremifene",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ospemifene"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Toremifene (Compound) resembles Ospemifene (Compound) and
Toremifene may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine (Compound) resembles Ospemifene (Compound)
Toremifene (Compound) resembles Benzyl Benzoate (Compound) and Benzyl Benzoate (Compound) resembles Ospemifene (Com... |
DB01156 | DB11921 | 593 | 1,019 | [
"DDInter252",
"DDInter492"
] | Bupropion | Deflazacort | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
593,
25,
1019
]
],
[
[
593,
63,
443
],
[
443,
24,
1019
]
],
[
[
593,
24,
1603
],
[
1603,
24,
1019
]
],
[
[
593,
25,
1372
],
[
1372,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
],
[
"Spirono... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Captopril and ... |
DB00048 | DB00278 | 1,595 | 291 | [
"DDInter435",
"DDInter117"
] | Collagenase clostridium histolyticum | Argatroban | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Moderate | 1 | [
[
[
1595,
24,
291
]
],
[
[
1595,
24,
578
],
[
578,
63,
291
]
],
[
[
1595,
24,
1167
],
[
1167,
25,
291
]
],
[
[
1595,
24,
707
],
[
707,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Argatroban"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Argatroban
Collagenase clostridium histolyticum may cause a moderate interaction that could exace... |
DB04845 | DB09115 | 309 | 505 | [
"DDInter1001",
"DDInter559"
] | Ixabepilone | Diiodohydroxyquinoline | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
309,
24,
505
]
],
[
[
309,
24,
1593
],
[
1593,
24,
505
]
],
[
[
309,
63,
467
],
[
467,
24,
505
]
],
[
[
309,
25,
908
],
[
908,
2... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Simvast... |
DB00615 | DB09330 | 690 | 985 | [
"DDInter1589",
"DDInter1352"
] | Rifabutin | Osimertinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
690,
25,
985
]
],
[
[
690,
64,
168
],
[
168,
23,
985
]
],
[
[
690,
24,
112
],
[
112,
23,
985
]
],
[
[
690,
62,
608
],
[
608,
23,... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u} ma... | Rifabutin may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cau... |
DB01232 | DB06292 | 1,327 | 549 | [
"DDInter1640",
"DDInter474"
] | Saquinavir | Dapagliflozin | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1327,
24,
549
]
],
[
[
1327,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1327,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1327,
21,
29222
],
[
29222... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Saquinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Saquinavir (Compound) causes Hypoglycaemia (Side Effec... |
DB00945 | DB06228 | 1,479 | 792 | [
"DDInter20",
"DDInter1609"
] | Acetylsalicylic acid | Rivaroxaban | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1479,
25,
792
]
],
[
[
1479,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1479,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1479,
23,
944
],
[
944,
... | [
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Acetylsalicylic acid (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Acetylsalicylic acid (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when take... |
DB00994 | DB01172 | 361 | 416 | [
"DDInter1277",
"DDInter1004"
] | Neomycin | Kanamycin | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
361,
35,
416
]
],
[
[
361,
62,
355
],
[
355,
1,
416
]
],
[
[
361,
40,
138
],
[
138,
1,
416
]
],
[
[
361,
1,
11405
],
[
11405,
1,... | [
[
[
"Neomycin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Neomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}... | Neomycin (Compound) resembles Kanamycin (Compound) and
Neomycin may cause a minor interaction that can limit clinical effects when taken with Lactulose and Lactulose (Compound) resembles Kanamycin (Compound)
Neomycin (Compound) resembles Tobramycin (Compound) and Tobramycin (Compound) resembles Kanamycin (Compound)
Neo... |
DB00860 | DB06718 | 891 | 1,687 | [
"DDInter1513",
"DDInter1709"
] | Prednisolone | Stanozolol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
891,
24,
1687
]
],
[
[
891,
35,
1546
],
[
1546,
1,
1687
]
],
[
[
891,
40,
989
],
[
989,
1,
1687
]
],
[
[
891,
63,
1561
],
[
1561,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when tak... | Prednisolone (Compound) resembles Methyltestosterone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Prednisolone (Compound) resembles Progesterone (Compound) and Progesterone... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.