drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00222 | DB00777 | 245 | 146 | [
"DDInter825",
"DDInter1537"
] | Glimepiride | Propiomazine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Moderate | 1 | [
[
[
245,
24,
146
]
],
[
[
245,
24,
508
],
[
508,
1,
146
]
],
[
[
245,
24,
401
],
[
401,
63,
146
]
],
[
[
245,
24,
104
],
[
104,
40,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Propiomazine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that... |
DB01575 | DB01627 | 1,054 | 1,208 | [
"DDInter1005",
"DDInter1071"
] | Kaolin | Lincomycin | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska. Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin re... | Moderate | 1 | [
[
[
1054,
24,
1208
]
],
[
[
1054,
63,
568
],
[
568,
40,
1208
]
],
[
[
1054,
62,
17
],
[
17,
21,
28719
],
[
28719,
60,
1208
]
],
[
[
1054,
... | [
[
[
"Kaolin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lincomycin"
]
],
[
[
"Kaolin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clindamycin"
],
[
"Cl... | Kaolin may cause a moderate interaction that could exacerbate diseases when taken with Clindamycin and Clindamycin (Compound) resembles Lincomycin (Compound)
Kaolin may cause a minor interaction that can limit clinical effects when taken with Sotalol and Sotalol (Compound) causes Pain (Side Effect) and Pain (Side Effec... |
DB11986 | DB12941 | 484 | 466 | [
"DDInter648",
"DDInter481"
] | Entrectinib | Darolutamide | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
484,
23,
466
]
],
[
[
484,
64,
1622
],
[
1622,
23,
466
]
],
[
[
484,
63,
336
],
[
336,
23,
466
]
],
[
[
484,
25,
283
],
[
283,
2... | [
[
[
"Entrectinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Entrectinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Vorico... | Entrectinib may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may ... |
DB00470 | DB01178 | 530 | 369 | [
"DDInter601",
"DDInter357"
] | Dronabinol | Chlormezanone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Moderate | 1 | [
[
[
530,
24,
369
]
],
[
[
530,
24,
1532
],
[
1532,
63,
369
]
],
[
[
530,
24,
272
],
[
272,
24,
369
]
],
[
[
530,
63,
13
],
[
13,
24,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlormezanone"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine a... |
DB00903 | DB09020 | 1,680 | 28 | [
"DDInter686",
"DDInter212"
] | Etacrynic acid | Bisacodyl | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1680,
24,
28
]
],
[
[
1680,
7,
5998
],
[
5998,
46,
28
]
],
[
[
1680,
7,
16638
],
[
16638,
57,
28
]
],
[
[
1680,
18,
3688
],
[
3688,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Etacrynic acid",
"{u} (Compound) upregulates {v} (Gene)",
"HMOX1"
],
[
"HMOX1",
"{u} (Gene) is upregulated by... | Etacrynic acid (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Bisacodyl (Compound)
Etacrynic acid (Compound) upregulates ABCB6 (Gene) and ABCB6 (Gene) is downregulated by Bisacodyl (Compound)
Etacrynic acid (Compound) downregulates CCNA2 (Gene) and CCNA2 (Gene) is downregulated by Bisacodyl (Com... |
DB00712 | DB09135 | 1,274 | 1,211 | [
"DDInter763",
"DDInter967"
] | Flurbiprofen | Ioxilan | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1274,
25,
1211
]
],
[
[
1274,
63,
17
],
[
17,
24,
1211
]
],
[
[
1274,
24,
887
],
[
887,
24,
1211
]
],
[
[
1274,
24,
242
],
[
242,
... | [
[
[
"Flurbiprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
],
[
"Sotalol",
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol may ... |
DB00818 | DB09080 | 898 | 144 | [
"DDInter1538",
"DDInter1331"
] | Propofol | Olodaterol | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
898,
24,
144
]
],
[
[
898,
24,
1011
],
[
1011,
24,
144
]
],
[
[
898,
63,
11
],
[
11,
24,
144
]
],
[
[
898,
24,
823
],
[
823,
63,... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
],
[
... | Propofol may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Propofol may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene... |
DB00476 | DB01246 | 109 | 820 | [
"DDInter608",
"DDInter45"
] | Duloxetine | Alimemazine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
109,
24,
820
]
],
[
[
109,
24,
104
],
[
104,
40,
820
]
],
[
[
109,
24,
401
],
[
401,
24,
820
]
],
[
[
109,
24,
649
],
[
649,
1,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00607 | DB09074 | 1,249 | 1,362 | [
"DDInter1256",
"DDInter1327"
] | Nafcillin | Olaparib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
1249,
25,
1362
]
],
[
[
1249,
24,
1478
],
[
1478,
24,
1362
]
],
[
[
1249,
63,
79
],
[
79,
24,
1362
]
],
[
[
1249,
62,
168
],
[
168,
... | [
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may... |
DB00631 | DB08870 | 372 | 850 | [
"DDInter405",
"DDInter228"
] | Clofarabine | Brentuximab vedotin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
372,
24,
850
]
],
[
[
372,
24,
788
],
[
788,
24,
850
]
],
[
[
372,
24,
496
],
[
496,
63,
850
]
],
[
[
372,
63,
1570
],
[
1570,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Hepati... |
DB01250 | DB09134 | 712 | 1,552 | [
"DDInter1334",
"DDInter966"
] | Olsalazine | Ioversol | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
712,
25,
1552
]
],
[
[
712,
24,
242
],
[
242,
63,
1552
]
],
[
[
712,
63,
848
],
[
848,
25,
1552
]
],
[
[
712,
24,
1381
],
[
1381,
... | [
[
[
"Olsalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Olsalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
[
"Remdesivir",... | Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen... |
DB00445 | DB06273 | 322 | 980 | [
"DDInter655",
"DDInter1824"
] | Epirubicin | Tocilizumab | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
322,
24,
980
]
],
[
[
322,
63,
1461
],
[
1461,
23,
980
]
],
[
[
322,
64,
494
],
[
494,
24,
980
]
],
[
[
322,
24,
139
],
[
139,
2... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tocilizumab
Epirubicin may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide may cause... |
DB09241 | DB13139 | 1,629 | 1,032 | [
"DDInter1186",
"DDInter1063"
] | Methylene blue | Levosalbutamol | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1629,
24,
1032
]
],
[
[
1629,
76,
1090
],
[
1090,
24,
1032
]
],
[
[
1629,
64,
121
],
[
121,
24,
1032
]
],
[
[
1629,
63,
659
],
[
659,
... | [
[
[
"Methylene blue",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Methylene blue",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a ma... | Methylene blue may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline and Methylene blue may lead to a major life threatening interaction when taken with Tetryzoline and Tetryzoline may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Methyl... |
DB00381 | DB08865 | 376 | 1,593 | [
"DDInter79",
"DDInter448"
] | Amlodipine | Crizotinib | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
376,
24,
1593
]
],
[
[
376,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
376,
7,
1881
],
[
1881,
46,
1593
]
],
[
[
376,
18,
3771
],
[
3771,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Amlodipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Amlodipine (Compound) upregulates SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Crizotinib (Compound)
Amlodipine (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is downregulated by Crizotinib (Compound)
Amlodipi... |
DB00549 | DB01229 | 522 | 973 | [
"DDInter1955",
"DDInter1377"
] | Zafirlukast | Paclitaxel | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
522,
24,
973
]
],
[
[
522,
24,
310
],
[
310,
63,
973
]
],
[
[
522,
6,
8374
],
[
8374,
45,
973
]
],
[
[
522,
21,
28643
],
[
28643,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Zafirlukast (C... |
DB00618 | DB01147 | 1,572 | 950 | [
"DDInter498",
"DDInter418"
] | Demeclocycline | Cloxacillin | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin]. | Moderate | 1 | [
[
[
1572,
24,
950
]
],
[
[
1572,
63,
1249
],
[
1249,
40,
950
]
],
[
[
1572,
24,
1366
],
[
1366,
1,
950
]
],
[
[
1572,
24,
319
],
[
319,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cloxacillin"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Cloxacillin (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Meticillin and Meticillin (Compound) resembles Cloxacillin (Co... |
DB00446 | DB11952 | 597 | 800 | [
"DDInter351",
"DDInter612"
] | Chloramphenicol | Duvelisib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
597,
24,
800
]
],
[
[
597,
23,
466
],
[
466,
62,
800
]
],
[
[
597,
24,
310
],
[
310,
24,
800
]
],
[
[
597,
25,
1476
],
[
1476,
6... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Chloramphenicol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],... | Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel ... |
DB00987 | DB08903 | 1,224 | 996 | [
"DDInter460",
"DDInter170"
] | Cytarabine | Bedaquiline | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
1224,
24,
996
]
],
[
[
1224,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1224,
24,
713
],
[
713,
63,
996
]
],
[
[
1224,
74,
372
],
[
372,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Cytarabine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Cytarabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline
Cy... |
DB00757 | DB08918 | 1,166 | 41 | [
"DDInter581",
"DDInter1059"
] | Dolasetron | Levomilnacipran | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Major | 2 | [
[
[
1166,
25,
41
]
],
[
[
1166,
25,
901
],
[
901,
40,
41
]
],
[
[
1166,
64,
1349
],
[
1349,
40,
41
]
],
[
[
1166,
6,
8374
],
[
8374,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
],
[
"Milnacipran",
... | Dolasetron may lead to a major life threatening interaction when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Meperidine and Meperidine (Compound) resembles Levomilnacipran (Compound)
Dolasetron (Compou... |
DB00364 | DB01124 | 417 | 1,411 | [
"DDInter1717",
"DDInter1828"
] | Sucralfate | Tolbutamide | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
417,
24,
1411
]
],
[
[
417,
24,
959
],
[
959,
40,
1411
]
],
[
[
417,
63,
245
],
[
245,
40,
1411
]
],
[
[
417,
21,
28829
],
[
28829,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound... |
DB00399 | DB00626 | 963 | 1,441 | [
"DDInter1968",
"DDInter161"
] | Zoledronic acid | Bacitracin | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Moderate | 1 | [
[
[
963,
24,
1441
]
],
[
[
963,
24,
1481
],
[
1481,
1,
1441
]
],
[
[
963,
21,
28719
],
[
28719,
60,
1441
]
],
[
[
963,
24,
1555
],
[
1555,... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
]
],
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
... | Zoledronic acid may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound)
Zoledronic acid (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Bacitracin (Compound)
Zoledronic acid may cause a moderate inter... |
DB11642 | DB11703 | 938 | 405 | [
"DDInter1480",
"DDInter9"
] | Pitolisant | Acalabrutinib | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
938,
24,
405
]
],
[
[
938,
25,
982
],
[
982,
63,
405
]
],
[
[
938,
24,
1297
],
[
1297,
63,
405
]
],
[
[
938,
63,
918
],
[
918,
2... | [
[
[
"Pitolisant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Pitolisant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivoside... | Pitolisant may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Pitolisant may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may... |
DB00193 | DB00927 | 534 | 1,559 | [
"DDInter1841",
"DDInter712"
] | Tramadol | Famotidine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
534,
24,
1559
]
],
[
[
534,
21,
28729
],
[
28729,
60,
1559
]
],
[
[
534,
24,
286
],
[
286,
62,
1559
]
],
[
[
534,
23,
112
],
[
112,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Tramadol",
"{u} (Compound) causes {v} (Side Effect)",
"Pain in extremity"
],
[
"Pain in extremity",
"{u} (Side Eff... | Tramadol (Compound) causes Pain in extremity (Side Effect) and Pain in extremity (Side Effect) is caused by Famotidine (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical eff... |
DB00382 | DB00888 | 62 | 1,001 | [
"DDInter1734",
"DDInter1133"
] | Tacrine | Mechlorethamine | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Minor | 0 | [
[
[
62,
23,
1001
]
],
[
[
62,
24,
51
],
[
51,
24,
1001
]
],
[
[
62,
24,
1362
],
[
1362,
63,
1001
]
],
[
[
62,
25,
1377
],
[
1377,
64... | [
[
[
"Tacrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mechlorethamine"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olapa... |
DB00081 | DB01105 | 273 | 222 | [
"DDInter1838",
"DDInter1665"
] | Tositumomab | Sibutramine | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
273,
24,
222
]
],
[
[
273,
24,
384
],
[
384,
62,
222
]
],
[
[
273,
25,
1046
],
[
1046,
63,
222
]
],
[
[
273,
25,
1027
],
[
1027,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Tositumomab may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may c... |
DB09068 | DB09472 | 1,427 | 1,383 | [
"DDInter1948",
"DDInter1693"
] | Vortioxetine | Sodium sulfate | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1427,
24,
1383
]
],
[
[
1427,
63,
1311
],
[
1311,
24,
1383
]
],
[
[
1427,
64,
1466
],
[
1466,
24,
1383
]
],
[
[
1427,
24,
971
],
[
971... | [
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
... | Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Vortioxetine may lead to a major life threatening interaction when taken with Phenylpropanolamine ... |
DB00431 | DB01165 | 1,503 | 1,539 | [
"DDInter1072",
"DDInter1325"
] | Lindane | Ofloxacin | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
1503,
24,
1539
]
],
[
[
1503,
24,
1467
],
[
1467,
1,
1539
]
],
[
[
1503,
63,
1176
],
[
1176,
1,
1539
]
],
[
[
1503,
24,
945
],
[
945,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
],
[
"Enox... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Lindane ... |
DB00432 | DB08880 | 1,083 | 1,510 | [
"DDInter1868",
"DDInter1771"
] | Trifluridine | Teriflunomide | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1083,
25,
1510
]
],
[
[
1083,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
1083,
24,
221
],
[
221,
63,
1510
]
],
[
[
1083,
24,
1136
],
[
1136... | [
[
[
"Trifluridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vita... | Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 ... |
DB09073 | DB11689 | 951 | 321 | [
"DDInter1379",
"DDInter1659"
] | Palbociclib | Selumetinib | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
[
951,
24,
321
]
],
[
[
951,
24,
982
],
[
982,
63,
321
]
],
[
[
951,
63,
392
],
[
392,
24,
321
]
],
[
[
951,
24,
98
],
[
98,
24,
... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
],
[... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapa... |
DB08886 | DB09079 | 637 | 1,496 | [
"DDInter126",
"DDInter1296"
] | Asparaginase Erwinia chrysanthemi | Nintedanib | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
637,
24,
1496
]
],
[
[
637,
63,
707
],
[
707,
24,
1496
]
],
[
[
637,
24,
498
],
[
498,
24,
1496
]
],
[
[
637,
24,
159
],
[
159,
... | [
[
[
"Asparaginase Erwinia chrysanthemi",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Asparaginase Erwinia chrysanthemi",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate ... |
DB00734 | DB01075 | 1,664 | 1,376 | [
"DDInter1605",
"DDInter569"
] | Risperidone | Diphenhydramine | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1664,
24,
1376
]
],
[
[
1664,
24,
649
],
[
649,
63,
1376
]
],
[
[
1664,
64,
11
],
[
11,
1,
1376
]
],
[
[
1664,
63,
128
],
[
128,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Risperidone may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Co... |
DB00771 | DB00843 | 262 | 479 | [
"DDInter397",
"DDInter583"
] | Clidinium | Donepezil | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
262,
24,
479
]
],
[
[
262,
63,
1442
],
[
1442,
24,
479
]
],
[
[
262,
24,
104
],
[
104,
63,
479
]
],
[
[
262,
74,
352
],
[
352,
2... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
],
[
... | Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil
Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methd... |
DB00278 | DB00834 | 291 | 932 | [
"DDInter117",
"DDInter1215"
] | Argatroban | Mifepristone | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
291,
25,
932
]
],
[
[
291,
6,
7524
],
[
7524,
45,
932
]
],
[
[
291,
21,
28762
],
[
28762,
60,
932
]
],
[
[
291,
24,
848
],
[
848,
... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Argatroban",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Mifep... | Argatroban (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Argatroban (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibu... |
DB01115 | DB11837 | 336 | 1,297 | [
"DDInter1291",
"DDInter1351"
] | Nifedipine | Osilodrostat | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
336,
24,
1297
]
],
[
[
336,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
336,
23,
466
],
[
466,
62,
1297
]
],
[
[
336,
23,
578
],
[
578,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Nifedipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Nifedipine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Nifedipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutami... |
DB00582 | DB09080 | 1,622 | 144 | [
"DDInter1946",
"DDInter1331"
] | Voriconazole | Olodaterol | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1622,
24,
144
]
],
[
[
1622,
25,
1011
],
[
1011,
24,
144
]
],
[
[
1622,
64,
11
],
[
11,
24,
144
]
],
[
[
1622,
24,
51
],
[
51,
2... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingol... | Voriconazole may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Voriconazole may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate ... |
DB00209 | DB00496 | 352 | 194 | [
"DDInter1886",
"DDInter480"
] | Trospium | Darifenacin | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Moderate | 1 | [
[
[
352,
35,
194
]
],
[
[
352,
24,
704
],
[
704,
1,
194
]
],
[
[
352,
24,
1511
],
[
1511,
63,
194
]
],
[
[
352,
40,
11264
],
[
11264,
... | [
[
[
"Trospium",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Trospium (Compound) resembles Darifenacin (Compound) and
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Darifenacin (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mep... |
DB00899 | DB00902 | 411 | 104 | [
"DDInter1579",
"DDInter1168"
] | Remifentanil | Methdilazine | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
411,
24,
104
]
],
[
[
411,
63,
13
],
[
13,
24,
104
]
],
[
[
411,
24,
820
],
[
820,
1,
104
]
],
[
[
411,
24,
537
],
[
537,
40,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]... | Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Alimema... |
DB00586 | DB04896 | 1,512 | 901 | [
"DDInter537",
"DDInter1220"
] | Diclofenac | Milnacipran | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1512,
24,
901
]
],
[
[
1512,
24,
41
],
[
41,
1,
901
]
],
[
[
1512,
21,
29271
],
[
29271,
60,
901
]
],
[
[
1512,
25,
405
],
[
405,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Diclofenac (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Milnacipran (Compound)
Diclofenac may lead to a major lif... |
DB00009 | DB01105 | 1,271 | 222 | [
"DDInter56",
"DDInter1665"
] | Alteplase | Sibutramine | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1271,
24,
222
]
],
[
[
1271,
25,
802
],
[
802,
63,
222
]
],
[
[
1271,
24,
1027
],
[
1027,
24,
222
]
],
[
[
1271,
25,
1432
],
[
1432,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
],
[
"Tinzaparin"... | Alteplase may lead to a major life threatening interaction when taken with Tinzaparin and Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam may cause a m... |
DB01100 | DB01218 | 1,568 | 1,493 | [
"DDInter1470",
"DDInter852"
] | Pimozide | Halofantrine | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
1568,
25,
1493
]
],
[
[
1568,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
1568,
7,
5998
],
[
5998,
46,
1493
]
],
[
[
1568,
18,
2183
],
[
21... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Halofantr... | Pimozide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Pimozide (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Halofantrine (Compound)
Pimozide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Halofantrine (Compound)
Pimozide (Comp... |
DB00512 | DB01135 | 91 | 648 | [
"DDInter1916",
"DDInter590"
] | Vancomycin | Doxacurium | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. | Moderate | 1 | [
[
[
91,
24,
648
]
],
[
[
91,
24,
1319
],
[
1319,
40,
648
]
],
[
[
91,
24,
1441
],
[
1441,
24,
648
]
],
[
[
91,
24,
361
],
[
361,
25,... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxacurium"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mivacurium"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Mivacurium and Mivacurium (Compound) resembles Doxacurium (Compound)
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin may cause a moderate interaction that could... |
DB00959 | DB01064 | 1,486 | 1,148 | [
"DDInter1191",
"DDInter987"
] | Methylprednisolone | Isoprenaline | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Minor | 0 | [
[
[
1486,
23,
1148
]
],
[
[
1486,
23,
480
],
[
480,
24,
1148
]
],
[
[
1486,
63,
1523
],
[
1523,
24,
1148
]
],
[
[
1486,
24,
887
],
[
887,
... | [
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoprenaline"
]
],
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Formoterol"
... | Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Labet... |
DB01254 | DB05679 | 1,213 | 1,683 | [
"DDInter484",
"DDInter1907"
] | Dasatinib | Ustekinumab | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1213,
24,
1683
]
],
[
[
1213,
64,
1401
],
[
1401,
24,
1683
]
],
[
[
1213,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
1213,
24,
309
],
[
309... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procainamide"
],
[
"Procainam... | Dasatinib may lead to a major life threatening interaction when taken with Procainamide and Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a... |
DB01075 | DB01192 | 1,376 | 560 | [
"DDInter569",
"DDInter1372"
] | Diphenhydramine | Oxymorphone | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
1376,
24,
560
]
],
[
[
1376,
63,
828
],
[
828,
1,
560
]
],
[
[
1376,
6,
12523
],
[
12523,
45,
560
]
],
[
[
1376,
21,
28817
],
[
28817,... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Diphenhydramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxymorphone (Compound)
Diphenhydramine (Compound) causes Vision blurred (Side E... |
DB00307 | DB00656 | 1,101 | 827 | [
"DDInter202",
"DDInter1851"
] | Bexarotene | Trazodone | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Moderate | 1 | [
[
[
1101,
24,
827
]
],
[
[
1101,
25,
623
],
[
623,
40,
827
]
],
[
[
1101,
24,
673
],
[
673,
1,
827
]
],
[
[
1101,
23,
851
],
[
851,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
]
],
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quetiapine"
],
[
"Quetiapine"... | Bexarotene may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Trazodone (Compound)
Bexarotene ma... |
DB00673 | DB08901 | 723 | 1,468 | [
"DDInter112",
"DDInter1492"
] | Aprepitant | Ponatinib | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
723,
24,
1468
]
],
[
[
723,
24,
478
],
[
478,
24,
1468
]
],
[
[
723,
6,
7524
],
[
7524,
45,
1468
]
],
[
[
723,
21,
29024
],
[
29024,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ponatinib (Compound)
Aprepitant (Compound) ... |
DB01259 | DB15233 | 392 | 1,650 | [
"DDInter1024",
"DDInter142"
] | Lapatinib | Avapritinib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
392,
24,
1650
]
],
[
[
392,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
392,
63,
1101
],
[
1101,
24,
1650
]
],
[
[
392,
25,
982
],
[
982,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexaroten... |
DB00408 | DB01612 | 1,408 | 1,637 | [
"DDInter1099",
"DDInter92"
] | Loxapine | Amyl Nitrite | An antipsychotic agent used in schizophrenia. [PubChem] | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1408,
24,
1637
]
],
[
[
1408,
64,
475
],
[
475,
24,
1637
]
],
[
[
1408,
24,
401
],
[
401,
24,
1637
]
],
[
[
1408,
25,
593
],
[
593,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Loxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphine",
... | Loxapine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a ... |
DB06718 | DB08870 | 1,687 | 850 | [
"DDInter1709",
"DDInter228"
] | Stanozolol | Brentuximab vedotin | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1687,
24,
850
]
],
[
[
1687,
63,
267
],
[
267,
24,
850
]
],
[
[
1687,
24,
1412
],
[
1412,
63,
850
]
],
[
[
1687,
40,
989
],
[
989,
... | [
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],... | Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase... |
DB00916 | DB01169 | 112 | 57 | [
"DDInter1202",
"DDInter120"
] | Metronidazole | Arsenic trioxide | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Minor | 0 | [
[
[
112,
23,
57
]
],
[
[
112,
6,
8374
],
[
8374,
45,
57
]
],
[
[
112,
23,
1247
],
[
1247,
23,
57
]
],
[
[
112,
63,
1516
],
[
1516,
2... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Metronidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic t... |
DB00502 | DB06282 | 1,300 | 516 | [
"DDInter853",
"DDInter1053"
] | Haloperidol | Levocetirizine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1300,
24,
516
]
],
[
[
1300,
63,
701
],
[
701,
24,
516
]
],
[
[
1300,
24,
407
],
[
407,
63,
516
]
],
[
[
1300,
24,
1219
],
[
1219,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium... |
DB00059 | DB00060 | 1,560 | 912 | [
"DDInter1404",
"DDInter947"
] | Pegaspargase | Interferon beta-1a | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Moderate | 1 | [
[
[
1560,
24,
912
]
],
[
[
1560,
24,
1154
],
[
1154,
63,
912
]
],
[
[
1560,
63,
342
],
[
342,
24,
912
]
],
[
[
1560,
25,
1101
],
[
1101,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Interfe... |
DB06788 | DB12245 | 1,616 | 823 | [
"DDInter864",
"DDInter1863"
] | Histrelin | Triclabendazole | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1616,
24,
823
]
],
[
[
1616,
62,
1247
],
[
1247,
23,
823
]
],
[
[
1616,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1616,
63,
1010
],
[
1010,... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Histrelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Histrelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavi... |
DB00197 | DB12301 | 1,324 | 907 | [
"DDInter1881",
"DDInter585"
] | Troglitazone | Doravirine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Moderate | 1 | [
[
[
1324,
24,
907
]
],
[
[
1324,
24,
1478
],
[
1478,
23,
907
]
],
[
[
1324,
24,
159
],
[
159,
62,
907
]
],
[
[
1324,
63,
966
],
[
966,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Lar... |
DB00619 | DB01069 | 1,419 | 401 | [
"DDInter909",
"DDInter1533"
] | Imatinib | Promethazine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1419,
24,
401
]
],
[
[
1419,
24,
146
],
[
146,
24,
401
]
],
[
[
1419,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1419,
64,
1236
],
[
1236,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin... |
DB00019 | DB11952 | 1,257 | 800 | [
"DDInter1405",
"DDInter612"
] | Pegfilgrastim | Duvelisib | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1257,
24,
800
]
],
[
[
1257,
24,
310
],
[
310,
24,
800
]
],
[
[
1257,
24,
564
],
[
564,
63,
800
]
],
[
[
1257,
24,
384
],
[
384,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib an... |
DB00331 | DB00978 | 1,645 | 739 | [
"DDInter1164",
"DDInter1084"
] | Metformin | Lomefloxacin | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
1645,
24,
739
]
],
[
[
1645,
24,
945
],
[
945,
40,
739
]
],
[
[
1645,
25,
246
],
[
246,
40,
739
]
],
[
[
1645,
63,
1176
],
[
1176,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Metformin may lead to a major life threatening interaction when taken with Gatifloxacin and Gatifloxacin (Compound) resembles Lomefloxacin (Compound)
Metfo... |
DB00741 | DB01165 | 167 | 1,539 | [
"DDInter885",
"DDInter1325"
] | Hydrocortisone | Ofloxacin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
167,
25,
1539
]
],
[
[
167,
64,
1467
],
[
1467,
1,
1539
]
],
[
[
167,
25,
945
],
[
945,
40,
1539
]
],
[
[
167,
25,
739
],
[
739,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxacin"
],
[
"Enoxacin",
"{u... | Hydrocortisone may lead to a major life threatening interaction when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Hydrocortisone may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Hydrocortisone may lead ... |
DB00701 | DB06616 | 1,091 | 594 | [
"DDInter90",
"DDInter224"
] | Amprenavir | Bosutinib | Amprenavir is a protease inhibitor used to treat HIV infection. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1091,
25,
594
]
],
[
[
1091,
63,
883
],
[
883,
1,
594
]
],
[
[
1091,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1091,
21,
29231
],
[
29231,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Amprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Amprenavir (Compound) causes Cardiac disorder (Side Effect) and Cardia... |
DB01583 | DB08882 | 624 | 1,281 | [
"DDInter1075",
"DDInter1070"
] | Liotrix | Linagliptin | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
624,
24,
1281
]
],
[
[
624,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
624,
6,
4973
],
[
4973,
45,
1281
]
],
[
[
624,
21,
29081
],
[
29081,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
"... | Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Liotrix (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Linagliptin (Compound)
Liotrix (Compound) causes Angioedema (Side Effect) and Angioedema (Side ... |
DB00798 | DB12615 | 1,132 | 1,381 | [
"DDInter815",
"DDInter1482"
] | Gentamicin | Plazomicin | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
1132,
24,
1381
]
],
[
[
1132,
62,
608
],
[
608,
23,
1381
]
],
[
[
1132,
24,
1479
],
[
1479,
24,
1381
]
],
[
[
1132,
63,
837
],
[
837,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Gentamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
... | Gentamicin may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Plazomicin
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Ac... |
DB00377 | DB00976 | 1,494 | 1,056 | [
"DDInter1382",
"DDInter1758"
] | Palonosetron | Telithromycin | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
1494,
24,
1056
]
],
[
[
1494,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
1494,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
1494,
21,
28681
],
[
28... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Palonosetron (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Palonosetron (Compound) causes Hypersensitivity (Sid... |
DB00358 | DB01599 | 1,010 | 1,232 | [
"DDInter1140",
"DDInter1523"
] | Mefloquine | Probucol | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
1010,
24,
1232
]
],
[
[
1010,
23,
112
],
[
112,
23,
1232
]
],
[
[
1010,
24,
1555
],
[
1555,
24,
1232
]
],
[
[
1010,
24,
927
],
[
927,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxali... |
DB00719 | DB04908 | 1,219 | 1,671 | [
"DDInter149",
"DDInter741"
] | Azatadine | Flibanserin | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1219,
24,
1671
]
],
[
[
1219,
40,
830
],
[
830,
24,
1671
]
],
[
[
1219,
63,
1594
],
[
1594,
24,
1671
]
],
[
[
1219,
24,
407
],
[
407,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Azatadine",
"{u} (Compound) resembles {v} (Compound)",
"Phenindamine"
],
[
"Phenindamine",
"{u} may cause a mode... | Azatadine (Compound) resembles Phenindamine (Compound) and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that co... |
DB00459 | DB12035 | 640 | 943 | [
"DDInter21",
"DDInter1641"
] | Acitretin | Sarecycline | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Major | 2 | [
[
[
640,
25,
943
]
],
[
[
640,
24,
850
],
[
850,
24,
943
]
],
[
[
640,
63,
322
],
[
322,
24,
943
]
],
[
[
640,
25,
213
],
[
213,
25,... | [
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sarecycline"
]
],
[
[
"Acitretin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
],
[
"Br... | Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Epir... |
DB09389 | DB11569 | 517 | 1,093 | [
"DDInter1315",
"DDInter1003"
] | Norgestrel | Ixekizumab | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
517,
24,
1093
]
],
[
[
517,
63,
1683
],
[
1683,
24,
1093
]
],
[
[
517,
63,
1057
],
[
1057,
25,
1093
]
],
[
[
517,
63,
1683
],
[
1683,
... | [
[
[
"Norgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Norgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Norgestrel may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Norgestrel may cause a moderate interaction that could exacerbate diseases when taken with Etanercept and Etan... |
DB08864 | DB08938 | 786 | 1,384 | [
"DDInter1595",
"DDInter1112"
] | Rilpivirine | Magaldrate | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
786,
24,
1384
]
],
[
[
786,
64,
1220
],
[
1220,
23,
1384
]
],
[
[
786,
63,
401
],
[
401,
23,
1384
]
],
[
[
786,
24,
1040
],
[
1040,
... | [
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Rilpivirine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexam... | Rilpivirine may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine ... |
DB00204 | DB00515 | 228 | 589 | [
"DDInter580",
"DDInter387"
] | Dofetilide | Cisplatin | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Major | 2 | [
[
[
228,
25,
589
]
],
[
[
228,
21,
28680
],
[
28680,
60,
589
]
],
[
[
228,
25,
77
],
[
77,
63,
589
]
],
[
[
228,
23,
891
],
[
891,
6... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
]
],
[
[
"Dofetilide",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Dofetilide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Cisplatin (Compound)
Dofetilide may lead to a major life threatening interaction when taken with Idarubicin and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin
Dofetilide may cause a ... |
DB00451 | DB09263 | 542 | 1,436 | [
"DDInter1064",
"DDInter1399"
] | Levothyroxine | Patiromer | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
542,
24,
1436
]
],
[
[
542,
24,
841
],
[
841,
63,
1436
]
],
[
[
542,
24,
660
],
[
660,
24,
1436
]
],
[
[
542,
63,
1645
],
[
1645,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anh... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous and Calcium glubionate anhydrous may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Levothyroxine may cause a moderate interaction that could exacerbate disea... |
DB00501 | DB15328 | 752 | 829 | [
"DDInter380",
"DDInter1896"
] | Cimetidine | Ubrogepant | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
752,
24,
829
]
],
[
[
752,
24,
1476
],
[
1476,
24,
829
]
],
[
[
752,
23,
1468
],
[
1468,
24,
829
]
],
[
[
752,
63,
883
],
[
883,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ponatinib and Ponatinib... |
DB00047 | DB09129 | 176 | 625 | [
"DDInter932",
"DDInter373"
] | Insulin glargine | Chromic chloride | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN). | Moderate | 1 | [
[
[
176,
24,
625
]
],
[
[
176,
24,
127
],
[
127,
24,
625
]
],
[
[
176,
24,
1385
],
[
1385,
63,
625
]
],
[
[
176,
24,
127
],
[
127,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromic chloride"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Chromic chloride
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Semaglu... |
DB00263 | DB00352 | 1,029 | 482 | [
"DDInter1727",
"DDInter1814"
] | Sulfisoxazole | Tioguanine | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Moderate | 1 | [
[
[
1029,
24,
482
]
],
[
[
1029,
63,
912
],
[
912,
24,
482
]
],
[
[
1029,
1,
1247
],
[
1247,
63,
482
]
],
[
[
1029,
24,
850
],
[
850,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
]
],
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
... | Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine
Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause... |
DB00374 | DB00749 | 1,061 | 59 | [
"DDInter1852",
"DDInter699"
] | Treprostinil | Etodolac | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
1061,
24,
59
]
],
[
[
1061,
6,
6017
],
[
6017,
45,
59
]
],
[
[
1061,
7,
7720
],
[
7720,
45,
59
]
],
[
[
1061,
21,
29187
],
[
29187,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Treprostinil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etodolac (Compound)
Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Etodolac (Compound)
Treprostinil (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Etodolac (Compound)
Treprostinil m... |
DB01259 | DB15822 | 392 | 69 | [
"DDInter1024",
"DDInter1504"
] | Lapatinib | Pralsetinib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
392,
24,
69
]
],
[
[
392,
24,
283
],
[
283,
24,
69
]
],
[
[
392,
63,
1213
],
[
1213,
24,
69
]
],
[
[
392,
25,
985
],
[
985,
24,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatini... |
DB06605 | DB09420 | 1,409 | 1,074 | [
"DDInter108",
"DDInter953"
] | Apixaban | Iodide I-123 | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1409,
24,
1074
]
],
[
[
1409,
64,
500
],
[
500,
24,
1074
]
],
[
[
1409,
24,
1004
],
[
1004,
63,
1074
]
],
[
[
1409,
63,
1220
],
[
1220... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
"Enoxaparin",... | Apixaban may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylat... |
DB09312 | DB00108 | 967 | 1,066 | [
"DDInter106",
"DDInter1268"
] | Antithymocyte immunoglobulin (rabbit) | Natalizumab | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Major | 2 | [
[
[
967,
64,
1066
]
],
[
[
967,
23,
1114
],
[
1114,
62,
1066
]
],
[
[
967,
24,
949
],
[
949,
63,
1066
]
],
[
[
967,
25,
375
],
[
375,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Natalizumab"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v... | Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Natalizumab
Antilymphocyte immunoglobulin (horse) may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effec... |
DB00450 | DB01177 | 78 | 77 | [
"DDInter603",
"DDInter904"
] | Droperidol | Idarubicin | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
78,
25,
77
]
],
[
[
78,
21,
28987
],
[
28987,
60,
77
]
],
[
[
78,
23,
112
],
[
112,
23,
77
]
],
[
[
78,
25,
823
],
[
823,
63,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Droperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Chills"
],
[
"Chills",
"{u} (Side Effect) is caused by {v} (Compound)"... | Droperidol (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Idarubicin
... |
DB00067 | DB01001 | 317 | 688 | [
"DDInter1921",
"DDInter1632"
] | Vasopressin | Salbutamol | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
317,
24,
688
]
],
[
[
317,
24,
874
],
[
874,
24,
688
]
],
[
[
317,
24,
1148
],
[
1148,
63,
688
]
],
[
[
317,
24,
870
],
[
870,
2... | [
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[... | Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB00331 | DB00712 | 1,645 | 1,274 | [
"DDInter1164",
"DDInter763"
] | Metformin | Flurbiprofen | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1645,
24,
1274
]
],
[
[
1645,
24,
935
],
[
935,
63,
1274
]
],
[
[
1645,
7,
3218
],
[
3218,
46,
1274
]
],
[
[
1645,
18,
5833
],
[
5833,... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Metformin (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is upregulated by Flurbiprofen (Compound)
Metfor... |
DB00912 | DB00960 | 473 | 887 | [
"DDInter1581",
"DDInter1471"
] | Repaglinide | Pindolol | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
473,
24,
887
]
],
[
[
473,
24,
819
],
[
819,
40,
887
]
],
[
[
473,
24,
1148
],
[
1148,
63,
887
]
],
[
[
473,
63,
88
],
[
88,
40,... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that c... |
DB00358 | DB00983 | 1,010 | 480 | [
"DDInter1140",
"DDInter776"
] | Mefloquine | Formoterol | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1010,
24,
480
]
],
[
[
1010,
24,
1148
],
[
1148,
63,
480
]
],
[
[
1010,
24,
1523
],
[
1523,
25,
480
]
],
[
[
1010,
6,
12523
],
[
12523... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Lab... |
DB09143 | DB15982 | 313 | 1,339 | [
"DDInter1701",
"DDInter193"
] | Sonidegib | Berotralstat | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
313,
25,
1339
]
],
[
[
313,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
313,
25,
283
],
[
283,
23,
1339
]
],
[
[
313,
63,
1213
],
[
1213,
... | [
[
[
"Sonidegib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Sonidegib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Sonidegib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a ... |
DB06404 | DB09381 | 1,514 | 192 | [
"DDInter869",
"DDInter678"
] | Human C1-esterase inhibitor | Esterified estrogens | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1514,
24,
192
]
],
[
[
1514,
64,
770
],
[
770,
25,
192
]
],
[
[
1514,
25,
350
],
[
350,
25,
192
]
],
[
[
1514,
64,
770
],
[
770,
... | [
[
[
"Human C1-esterase inhibitor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Human C1-esterase inhibitor",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Human C1-esterase inhibitor may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a major life threatening interaction when taken with Esterified estrogens
Human C1-esterase inhibitor may lead to a major life threatening interaction when taken with Carfilzomib and Carf... |
DB00197 | DB01155 | 1,324 | 872 | [
"DDInter1881",
"DDInter813"
] | Troglitazone | Gemifloxacin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1324,
24,
872
]
],
[
[
1324,
24,
956
],
[
956,
1,
872
]
],
[
[
1324,
25,
246
],
[
246,
1,
872
]
],
[
[
1324,
24,
450
],
[
450,
2... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles Gemifloxacin (Compound)
Troglitazone may lead to a major life threatening interaction when taken with Gatifloxacin and Gatifloxacin (Compound) resembles Gemifloxacin (Compound)
T... |
DB11581 | DB14723 | 1,456 | 159 | [
"DDInter1926",
"DDInter1026"
] | Venetoclax | Larotrectinib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1456,
24,
159
]
],
[
[
1456,
24,
466
],
[
466,
23,
159
]
],
[
[
1456,
64,
271
],
[
271,
23,
159
]
],
[
[
1456,
62,
1135
],
[
1135,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Venetoclax may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may c... |
DB01050 | DB01193 | 848 | 819 | [
"DDInter900",
"DDInter12"
] | Ibuprofen | Acebutolol | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
848,
24,
819
]
],
[
[
848,
63,
887
],
[
887,
1,
819
]
],
[
[
848,
40,
236
],
[
236,
1,
819
]
],
[
[
848,
6,
4973
],
[
4973,
45,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Ibuprofen (Compound) resembles Esmolol (Compound) and Esmolol (Compound) resembles Acebutolol (Compound)
Ibuprofen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is ... |
DB00518 | DB12332 | 510 | 1,619 | [
"DDInter35",
"DDInter1626"
] | Albendazole | Rucaparib | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
510,
24,
1619
]
],
[
[
510,
23,
307
],
[
307,
23,
1619
]
],
[
[
510,
24,
1213
],
[
1213,
24,
1619
]
],
[
[
510,
24,
159
],
[
159,
... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Albendazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Albendazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib ma... |
DB01095 | DB01229 | 671 | 973 | [
"DDInter769",
"DDInter1378"
] | Fluvastatin | Paclitaxel (protein-bound) | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
671,
24,
973
]
],
[
[
671,
24,
310
],
[
310,
63,
973
]
],
[
[
671,
6,
7524
],
[
7524,
45,
973
]
],
[
[
671,
7,
2903
],
[
2903,
4... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Fluvas... |
DB00601 | DB01612 | 453 | 1,637 | [
"DDInter1073",
"DDInter92"
] | Linezolid | Amyl Nitrite | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
453,
24,
1637
]
],
[
[
453,
24,
714
],
[
714,
24,
1637
]
],
[
[
453,
64,
475
],
[
475,
24,
1637
]
],
[
[
453,
63,
1061
],
[
1061,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Linezolid may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a modera... |
DB00570 | DB00976 | 147 | 1,056 | [
"DDInter1936",
"DDInter1758"
] | Vinblastine | Telithromycin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Major | 2 | [
[
[
147,
25,
1056
]
],
[
[
147,
6,
12523
],
[
12523,
45,
1056
]
],
[
[
147,
21,
28681
],
[
28681,
60,
1056
]
],
[
[
147,
24,
112
],
[
112,... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telithromycin"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Te... | Vinblastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Telithromycin (Compound)
Vinblastine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Telithromycin (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01168 | DB01367 | 1,053 | 1,163 | [
"DDInter1526",
"DDInter1572"
] | Procarbazine | Rasagiline | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Major | 2 | [
[
[
1053,
25,
1163
]
],
[
[
1053,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
1053,
63,
100
],
[
100,
24,
1163
]
],
[
[
1053,
64,
1445
],
[
14... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rasagiline"
]
],
[
[
"Procarbazine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused by {v} (Co... | Procarbazine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01359 | DB09080 | 729 | 144 | [
"DDInter1417",
"DDInter1331"
] | Penbutolol | Olodaterol | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Major | 2 | [
[
[
729,
25,
144
]
],
[
[
729,
25,
1011
],
[
1011,
24,
144
]
],
[
[
729,
63,
1264
],
[
1264,
24,
144
]
],
[
[
729,
24,
1154
],
[
1154,
... | [
[
[
"Penbutolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olodaterol"
]
],
[
[
"Penbutolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolimod",
"{u} m... | Penbutolol may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a mode... |
DB08822 | DB09268 | 911 | 1,662 | [
"DDInter156",
"DDInter1464"
] | Azilsartan medoxomil | Picosulfuric acid | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
911,
24,
1662
]
],
[
[
911,
63,
708
],
[
708,
24,
1662
]
],
[
[
911,
24,
407
],
[
407,
63,
1662
]
],
[
[
911,
40,
240
],
[
240,
... | [
[
[
"Azilsartan medoxomil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Azilsartan medoxomil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Azilsartan medoxomil may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Azilsartan medoxomil may cause a moderate interaction that could exacerbate diseases when... |
DB00193 | DB06788 | 534 | 1,616 | [
"DDInter1841",
"DDInter864"
] | Tramadol | Histrelin | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
534,
24,
1616
]
],
[
[
534,
23,
112
],
[
112,
23,
1616
]
],
[
[
534,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
534,
24,
603
],
[
603,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Tramadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Tramadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsi... |
DB09061 | DB11986 | 1,627 | 484 | [
"DDInter284",
"DDInter648"
] | Cannabidiol | Entrectinib | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1627,
24,
484
]
],
[
[
1627,
63,
222
],
[
222,
23,
484
]
],
[
[
1627,
63,
322
],
[
322,
24,
484
]
],
[
[
1627,
24,
1320
],
[
1320,
... | [
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epi... |
DB00374 | DB00722 | 1,061 | 743 | [
"DDInter1852",
"DDInter1079"
] | Treprostinil | Lisinopril | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
1061,
24,
743
]
],
[
[
1061,
24,
610
],
[
610,
40,
743
]
],
[
[
1061,
24,
1638
],
[
1638,
1,
743
]
],
[
[
1061,
21,
28949
],
[
28949,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Lisinopril (Comp... |
DB01278 | DB06077 | 1,021 | 879 | [
"DDInter1506",
"DDInter1102"
] | Pramlintide | Lumateperone | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1021,
24,
879
]
],
[
[
1021,
63,
1144
],
[
1144,
24,
879
]
],
[
[
1021,
24,
1511
],
[
1511,
24,
879
]
],
[
[
1021,
24,
1296
],
[
1296,... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and... |
DB00813 | DB12010 | 704 | 214 | [
"DDInter722",
"DDInter785"
] | Fentanyl | Fostamatinib | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
704,
24,
214
]
],
[
[
704,
24,
976
],
[
976,
24,
214
]
],
[
[
704,
64,
723
],
[
723,
24,
214
]
],
[
[
704,
25,
574
],
[
574,
24,... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[
... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Fentanyl may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause ... |
DB06699 | DB11796 | 774 | 1,612 | [
"DDInter493",
"DDInter786"
] | Degarelix | Fostemsavir | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
774,
24,
1612
]
],
[
[
774,
62,
112
],
[
112,
23,
1612
]
],
[
[
774,
63,
1424
],
[
1424,
24,
1612
]
],
[
[
774,
24,
823
],
[
823,
... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine ... |
DB00014 | DB01100 | 521 | 1,568 | [
"DDInter839",
"DDInter1470"
] | Goserelin | Pimozide | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
521,
25,
1568
]
],
[
[
521,
25,
78
],
[
78,
40,
1568
]
],
[
[
521,
24,
1557
],
[
1557,
25,
1568
]
],
[
[
521,
21,
29024
],
[
29024,
... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u} (Comp... | Goserelin may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may lead to a major life threatening interaction when taken wi... |
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