drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00530 | DB01377 | 1,195 | 1,283 | [
"DDInter667",
"DDInter1119"
] | Erlotinib | Magnesium oxide | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1195,
24,
1283
]
],
[
[
1195,
24,
1468
],
[
1468,
62,
1283
]
],
[
[
1195,
24,
1194
],
[
1194,
23,
1283
]
],
[
[
1195,
63,
752
],
[
752... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitid... |
DB00431 | DB00934 | 1,503 | 413 | [
"DDInter1072",
"DDInter1124"
] | Lindane | Maprotiline | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1503,
24,
413
]
],
[
[
1503,
63,
1302
],
[
1302,
40,
413
]
],
[
[
1503,
21,
28762
],
[
28762,
60,
413
]
],
[
[
1503,
24,
22
],
[
22,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Lindane (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Maprotiline (Compound)
Lindane may cause a moderate interaction tha... |
DB00976 | DB01229 | 1,056 | 973 | [
"DDInter1758",
"DDInter1377"
] | Telithromycin | Paclitaxel | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1056,
24,
973
]
],
[
[
1056,
24,
310
],
[
310,
63,
973
]
],
[
[
1056,
6,
7524
],
[
7524,
45,
973
]
],
[
[
1056,
21,
28779
],
[
28779,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Telithromycin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Telithromy... |
DB00014 | DB04844 | 521 | 843 | [
"DDInter839",
"DDInter1778"
] | Goserelin | Tetrabenazine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
521,
24,
843
]
],
[
[
521,
24,
479
],
[
479,
40,
843
]
],
[
[
521,
21,
28698
],
[
28698,
60,
843
]
],
[
[
521,
23,
112
],
[
112,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Goserelin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Tetrabenazine (Compound)
Goserelin may cause a minor interaction that... |
DB00841 | DB01001 | 532 | 688 | [
"DDInter577",
"DDInter1632"
] | Dobutamine | Salbutamol | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
532,
24,
688
]
],
[
[
532,
24,
455
],
[
455,
24,
688
]
],
[
[
532,
24,
1148
],
[
1148,
63,
688
]
],
[
[
532,
6,
1704
],
[
1704,
... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isop... |
DB00553 | DB00759 | 92 | 1,620 | [
"DDInter1177",
"DDInter1783"
] | Methoxsalen | Tetracycline | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
92,
24,
1620
]
],
[
[
92,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
92,
63,
964
],
[
964,
40,
1620
]
],
[
[
92,
6,
8374
],
[
8374,
4... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Tetracyc... |
DB01073 | DB12240 | 1,488 | 110 | [
"DDInter745",
"DDInter1485"
] | Fludarabine | Polatuzumab vedotin | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1488,
24,
110
]
],
[
[
1488,
63,
467
],
[
467,
24,
110
]
],
[
[
1488,
40,
372
],
[
372,
24,
110
]
],
[
[
1488,
24,
980
],
[
980,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Fludarabine (Compound) resembles Clofarabine (Compound) and Clofarabine may cause a moderate interac... |
DB00398 | DB08865 | 79 | 1,593 | [
"DDInter1702",
"DDInter448"
] | Sorafenib | Crizotinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
79,
25,
1593
]
],
[
[
79,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
79,
7,
2900
],
[
2900,
46,
1593
]
],
[
[
79,
18,
5335
],
[
5335,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotini... | Sorafenib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Sorafenib (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Crizotinib (Compound)
Sorafenib (Compound) downregulates LDLR (Gene) and LDLR (Gene) is upregulated by Crizotinib (Compound)
Sorafenib (Compound... |
DB00783 | DB01284 | 1,438 | 1,042 | [
"DDInter679",
"DDInter1782"
] | Estradiol | Tetracosactide | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1438,
24,
1042
]
],
[
[
1438,
23,
771
],
[
771,
62,
1042
]
],
[
[
1438,
24,
761
],
[
761,
63,
1042
]
],
[
[
1438,
1,
1561
],
[
1561,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Estradiol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],
[... | Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and S... |
DB01238 | DB09280 | 673 | 1,604 | [
"DDInter118",
"DDInter1101"
] | Aripiprazole | Lumacaftor | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
673,
24,
1604
]
],
[
[
673,
63,
473
],
[
473,
24,
1604
]
],
[
[
673,
64,
593
],
[
593,
24,
1604
]
],
[
[
673,
24,
1281
],
[
1281,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Aripiprazole may lead to a major life threatening interaction when taken with Bupropion and Bupropion may ca... |
DB00054 | DB00460 | 1,432 | 612 | [
"DDInter6",
"DDInter1929"
] | Abciximab | Verteporfin | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
1432,
24,
612
]
],
[
[
1432,
63,
942
],
[
942,
24,
612
]
],
[
[
1432,
25,
936
],
[
936,
63,
612
]
],
[
[
1432,
24,
1512
],
[
1512,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bivalirudin"
],
[
... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Bivalirudin and Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin
Abciximab may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may cause a... |
DB00675 | DB01080 | 888 | 855 | [
"DDInter1744",
"DDInter1933"
] | Tamoxifen | Vigabatrin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Major | 2 | [
[
[
888,
25,
855
]
],
[
[
888,
7,
5833
],
[
5833,
57,
855
]
],
[
[
888,
21,
28719
],
[
28719,
60,
855
]
],
[
[
888,
63,
1010
],
[
1010,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vigabatrin"
]
],
[
[
"Tamoxifen",
"{u} (Compound) upregulates {v} (Gene)",
"ACAT2"
],
[
"ACAT2",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Tamoxifen (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Vigabatrin (Compound)
Tamoxifen (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vigabatrin (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Meflo... |
DB00581 | DB11837 | 355 | 1,297 | [
"DDInter1018",
"DDInter1351"
] | Lactulose | Osilodrostat | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
355,
24,
1297
]
],
[
[
355,
24,
623
],
[
623,
24,
1297
]
],
[
[
355,
63,
1555
],
[
1555,
24,
1297
]
],
[
[
355,
24,
971
],
[
971,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxali... |
DB01001 | DB01087 | 688 | 1,520 | [
"DDInter1632",
"DDInter1520"
] | Salbutamol | Primaquine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
688,
24,
1520
]
],
[
[
688,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
688,
6,
8374
],
[
8374,
45,
1520
]
],
[
[
688,
21,
28722
],
[
28722,... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Primaquine (Compound)
Salbutamol (Compo... |
DB11581 | DB15328 | 1,456 | 829 | [
"DDInter1926",
"DDInter1896"
] | Venetoclax | Ubrogepant | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
1456,
24,
829
]
],
[
[
1456,
24,
1476
],
[
1476,
24,
829
]
],
[
[
1456,
64,
1468
],
[
1468,
24,
829
]
],
[
[
1456,
25,
124
],
[
124,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Venetoclax may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a ... |
DB00619 | DB00637 | 1,419 | 1,557 | [
"DDInter909",
"DDInter128"
] | Imatinib | Astemizole | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
1419,
24,
1557
]
],
[
[
1419,
25,
704
],
[
704,
1,
1557
]
],
[
[
1419,
25,
1568
],
[
1568,
64,
1557
]
],
[
[
1419,
6,
21998
],
[
21998... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
... | Imatinib may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Astemizole (Compound)
Imatinib may lead to a major life threatening interaction when taken with Pimozide and Pimozide may lead to a major life threatening interaction when taken with Astemizole
Imatinib ... |
DB00758 | DB01191 | 1,347 | 1,039 | [
"DDInter413",
"DDInter518"
] | Clopidogrel | Dexfenfluramine | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1347,
24,
1039
]
],
[
[
1347,
6,
10215
],
[
10215,
45,
1039
]
],
[
[
1347,
6,
5182
],
[
5182,
46,
1039
]
],
[
[
1347,
25,
1046
],
[
10... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Co... | Clopidogrel (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexfenfluramine (Compound)
Clopidogrel (Compound) binds CES1 (Gene) and CES1 (Gene) is upregulated by Dexfenfluramine (Compound)
Clopidogrel may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause... |
DB00377 | DB08918 | 1,494 | 41 | [
"DDInter1382",
"DDInter1059"
] | Palonosetron | Levomilnacipran | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Major | 2 | [
[
[
1494,
25,
41
]
],
[
[
1494,
25,
901
],
[
901,
40,
41
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
41
]
],
[
[
1494,
21,
28643
],
[
28643,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
],
[
"Milnacipran",
... | Palonosetron may lead to a major life threatening interaction when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levomilnacipran (Compound)
Palonosetron (Compound) causes Infection (Side Effect) and Infect... |
DB04932 | DB15233 | 1,564 | 1,650 | [
"DDInter491",
"DDInter142"
] | Defibrotide | Avapritinib | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1564,
25,
1650
]
],
[
[
1564,
63,
765
],
[
765,
24,
1650
]
],
[
[
1564,
24,
738
],
[
738,
24,
1650
]
],
[
[
1564,
63,
1512
],
[
1512,
... | [
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Defibrotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
],
[
"Hemin",
... | Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may ... |
DB00539 | DB06663 | 11 | 1,154 | [
"DDInter1837",
"DDInter1398"
] | Toremifene | Pasireotide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
11,
25,
1154
]
],
[
[
11,
21,
28898
],
[
28898,
60,
1154
]
],
[
[
11,
23,
112
],
[
112,
23,
1154
]
],
[
[
11,
63,
62
],
[
62,
24... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Toremifene",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (Side Effect) is caused by {v... | Toremifene (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Pasireotide (Compound)
Toremifene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wit... |
DB01058 | DB11730 | 978 | 351 | [
"DDInter1510",
"DDInter1588"
] | Praziquantel | Ribociclib | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
978,
24,
351
]
],
[
[
978,
24,
283
],
[
283,
62,
351
]
],
[
[
978,
63,
288
],
[
288,
24,
351
]
],
[
[
978,
24,
1654
],
[
1654,
6... | [
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
... | Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Buta... |
DB00308 | DB11986 | 347 | 484 | [
"DDInter901",
"DDInter648"
] | Ibutilide | Entrectinib | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
347,
25,
484
]
],
[
[
347,
23,
112
],
[
112,
23,
484
]
],
[
[
347,
25,
774
],
[
774,
24,
484
]
],
[
[
347,
24,
603
],
[
603,
24,... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Ibutilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Ibutilide may lead to a major life threatening interaction when taken with Degarelix and Degarelix may cause a... |
DB00222 | DB01110 | 245 | 86 | [
"DDInter825",
"DDInter1209"
] | Glimepiride | Miconazole | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Major | 2 | [
[
[
245,
25,
86
]
],
[
[
245,
6,
6017
],
[
6017,
45,
86
]
],
[
[
245,
21,
29081
],
[
29081,
60,
86
]
],
[
[
245,
24,
318
],
[
318,
6... | [
[
[
"Glimepiride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Miconazole"
]
],
[
[
"Glimepiride",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Micon... | Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Miconazole (Compound)
Glimepiride (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Miconazole (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram a... |
DB00761 | DB09564 | 1,621 | 1,296 | [
"DDInter1497",
"DDInter930"
] | Potassium chloride | Insulin degludec | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Minor | 0 | [
[
[
1621,
23,
1296
]
],
[
[
1621,
25,
104
],
[
104,
24,
1296
]
],
[
[
1621,
64,
217
],
[
217,
24,
1296
]
],
[
[
1621,
24,
914
],
[
914,
... | [
[
[
"Potassium chloride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Insulin degludec"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methdilazine"
],
... | Potassium chloride may lead to a major life threatening interaction when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Potassium chloride may lead to a major life threatening interaction when taken with Olmesartan and Olmesartan... |
DB00682 | DB01268 | 126 | 1,151 | [
"DDInter1951",
"DDInter1731"
] | Warfarin | Sunitinib | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
126,
24,
1151
]
],
[
[
126,
6,
8374
],
[
8374,
45,
1151
]
],
[
[
126,
25,
1247
],
[
1247,
23,
1151
]
],
[
[
126,
24,
655
],
[
655,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sunitinib (Compound)
Warfarin may lead to a major life threatening interaction when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Sunitinib
Warfarin may cause a moderate... |
DB06228 | DB06595 | 792 | 1,491 | [
"DDInter1609",
"DDInter1214"
] | Rivaroxaban | Midostaurin | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
792,
24,
1491
]
],
[
[
792,
63,
58
],
[
58,
24,
1491
]
],
[
[
792,
24,
1017
],
[
1017,
63,
1491
]
],
[
[
792,
24,
655
],
[
655,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorla... |
DB00731 | DB11071 | 1,144 | 1,004 | [
"DDInter1269",
"DDInter1449"
] | Nateglinide | Phenyl salicylate | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1144,
24,
1004
]
],
[
[
1144,
24,
1411
],
[
1411,
24,
1004
]
],
[
[
1144,
63,
1573
],
[
1573,
24,
1004
]
],
[
[
1144,
24,
1019
],
[
10... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone... |
DB01233 | DB04843 | 1,311 | 1,511 | [
"DDInter1197",
"DDInter1149"
] | Metoclopramide | Mepenzolate | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1311,
24,
1511
]
],
[
[
1311,
64,
675
],
[
675,
24,
1511
]
],
[
[
1311,
63,
537
],
[
537,
24,
1511
]
],
[
[
1311,
24,
649
],
[
649,
... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Metoclopramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
[
... | Metoclopramide may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine a... |
DB06209 | DB12887 | 256 | 1,598 | [
"DDInter1508",
"DDInter1750"
] | Prasugrel | Tazemetostat | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Major | 2 | [
[
[
256,
25,
1598
]
],
[
[
256,
24,
738
],
[
738,
24,
1598
]
],
[
[
256,
63,
1039
],
[
1039,
24,
1598
]
],
[
[
256,
62,
888
],
[
888,
... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tazemetostat"
]
],
[
[
"Prasugrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
"Niraparib",... | Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dex... |
DB00374 | DB01244 | 1,061 | 762 | [
"DDInter1852",
"DDInter192"
] | Treprostinil | Bepridil | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1061,
24,
762
]
],
[
[
1061,
24,
601
],
[
601,
40,
762
]
],
[
[
1061,
7,
7067
],
[
7067,
45,
762
]
],
[
[
1061,
21,
28698
],
[
28698,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethaphan"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Trimethaphan and Trimethaphan (Compound) resembles Bepridil (Compound)
Treprostinil (Compound) upregulates PDE1A (Gene) and PDE1A (Gene) is bound by Bepridil (Compound)
Treprostinil (Compound) causes Insomnia (Side Effect) and ... |
DB11921 | DB14409 | 1,019 | 1,129 | [
"DDInter492",
"DDInter867"
] | Deflazacort | Human adenovirus e serotype 4 strain cl-68578 antigen | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1019,
24,
1129
]
],
[
[
1019,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1019,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
1019,
24,
270
],
[
270... | [
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Deflazacort",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Deflazacort may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Deflazacort may cause a moderate interaction that could exacerbate diseases when ta... |
DB00889 | DB01174 | 1,133 | 697 | [
"DDInter840",
"DDInter1442"
] | Granisetron | Phenobarbital | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Minor | 0 | [
[
[
1133,
23,
697
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
697
]
],
[
[
1133,
21,
28741
],
[
28741,
60,
697
]
],
[
[
1133,
63,
1101
],
[
1101... | [
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenobarbital"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenobarbital (Compound)
Granisetron (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Phenobarbital (Compound)
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene... |
DB00364 | DB01261 | 417 | 170 | [
"DDInter1717",
"DDInter1679"
] | Sucralfate | Sitagliptin | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
417,
24,
170
]
],
[
[
417,
21,
29707
],
[
29707,
60,
170
]
],
[
[
417,
24,
52
],
[
52,
62,
170
]
],
[
[
417,
24,
1252
],
[
1252,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Sucralfate",
"{u} (Compound) causes {v} (Side Effect)",
"Lung disorder"
],
[
"Lung disorder",
"{u} (Side Effect... | Sucralfate (Compound) causes Lung disorder (Side Effect) and Lung disorder (Side Effect) is caused by Sitagliptin (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken wit... |
DB08912 | DB11952 | 1,040 | 800 | [
"DDInter462",
"DDInter612"
] | Dabrafenib | Duvelisib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1040,
24,
800
]
],
[
[
1040,
24,
466
],
[
466,
62,
800
]
],
[
[
1040,
63,
222
],
[
222,
23,
800
]
],
[
[
1040,
63,
310
],
[
310,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibu... |
DB00095 | DB01229 | 66 | 973 | [
"DDInter623",
"DDInter1378"
] | Efalizumab | Paclitaxel (protein-bound) | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
66,
24,
973
]
],
[
[
66,
24,
310
],
[
310,
63,
973
]
],
[
[
66,
24,
134
],
[
134,
24,
973
]
],
[
[
66,
23,
1461
],
[
1461,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Efalizum... |
DB09133 | DB15066 | 1,527 | 445 | [
"DDInter965",
"DDInter821"
] | Iothalamic acid | Givosiran | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Major | 2 | [
[
[
1527,
25,
445
]
],
[
[
1527,
64,
589
],
[
589,
24,
445
]
],
[
[
1527,
64,
629
],
[
629,
25,
445
]
],
[
[
1527,
64,
589
],
[
589,
... | [
[
[
"Iothalamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Givosiran"
]
],
[
[
"Iothalamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
],
[
"Cisplatin",
... | Iothalamic acid may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Iothalamic acid may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may lead to a major ... |
DB00653 | DB01133 | 544 | 1,104 | [
"DDInter1120",
"DDInter1808"
] | Magnesium sulfate | Tiludronic acid | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Moderate | 1 | [
[
[
544,
24,
1104
]
],
[
[
544,
25,
361
],
[
361,
24,
1104
]
],
[
[
544,
24,
853
],
[
853,
63,
1104
]
],
[
[
544,
25,
416
],
[
416,
... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiludronic acid"
]
],
[
[
"Magnesium sulfate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
],
[
... | Magnesium sulfate may lead to a major life threatening interaction when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Tiludronic acid
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride an... |
DB00486 | DB01215 | 1,614 | 1,418 | [
"DDInter1253",
"DDInter677"
] | Nabilone | Estazolam | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
1614,
24,
1418
]
],
[
[
1614,
63,
523
],
[
523,
1,
1418
]
],
[
[
1614,
24,
1216
],
[
1216,
40,
1418
]
],
[
[
1614,
63,
905
],
[
905,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
"... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Nabilo... |
DB00722 | DB08907 | 743 | 1,344 | [
"DDInter1079",
"DDInter280"
] | Lisinopril | Canagliflozin | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
743,
24,
1344
]
],
[
[
743,
24,
549
],
[
549,
1,
1344
]
],
[
[
743,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
743,
21,
28962
],
[
28962,
... | [
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Lisinopril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Lisinopril (Compound) causes Hyperkalaemia (Side Effect)... |
DB00580 | DB08899 | 311 | 129 | [
"DDInter1910",
"DDInter649"
] | Valdecoxib | Enzalutamide | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
311,
24,
129
]
],
[
[
311,
24,
112
],
[
112,
23,
129
]
],
[
[
311,
25,
1510
],
[
1510,
24,
129
]
],
[
[
311,
24,
1512
],
[
1512,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Enzalutamide
Valdecoxib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomid... |
DB01244 | DB11130 | 762 | 407 | [
"DDInter192",
"DDInter1344"
] | Bepridil | Opium | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
762,
24,
407
]
],
[
[
762,
24,
976
],
[
976,
24,
407
]
],
[
[
762,
63,
770
],
[
770,
24,
407
]
],
[
[
762,
64,
1264
],
[
1264,
2... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[
"Tof... | Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Opium
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide ... |
DB01148 | DB04837 | 1,128 | 649 | [
"DDInter738",
"DDInter407"
] | Flavoxate | Clofedanol | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1128,
24,
649
]
],
[
[
1128,
63,
1376
],
[
1376,
24,
649
]
],
[
[
1128,
63,
832
],
[
832,
40,
649
]
],
[
[
1128,
24,
1511
],
[
1511,
... | [
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamin... |
DB00443 | DB08820 | 251 | 1,478 | [
"DDInter195",
"DDInter997"
] | Betamethasone | Ivacaftor | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
251,
24,
1478
]
],
[
[
251,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
251,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
251,
23,
307
],
[
307,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Betamethasone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Betamethasone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Mo... |
DB08904 | DB15091 | 375 | 676 | [
"DDInter342",
"DDInter1901"
] | Certolizumab pegol | Upadacitinib | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
375,
25,
676
]
],
[
[
375,
23,
1193
],
[
1193,
23,
676
]
],
[
[
375,
62,
1461
],
[
1461,
23,
676
]
],
[
[
375,
63,
1430
],
[
1430,
... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
... | Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with V... |
DB01069 | DB01155 | 401 | 872 | [
"DDInter1533",
"DDInter813"
] | Promethazine | Gemifloxacin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
401,
24,
872
]
],
[
[
401,
63,
739
],
[
739,
1,
872
]
],
[
[
401,
25,
945
],
[
945,
40,
872
]
],
[
[
401,
64,
1176
],
[
1176,
1,... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Promethazine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gemifloxacin (Compound)... |
DB00434 | DB01114 | 13 | 272 | [
"DDInter459",
"DDInter362"
] | Cyproheptadine | Chlorpheniramine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
13,
24,
272
]
],
[
[
13,
24,
358
],
[
358,
63,
272
]
],
[
[
13,
63,
128
],
[
128,
24,
272
]
],
[
[
13,
40,
465
],
[
465,
1,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Dex... |
DB06700 | DB09080 | 643 | 144 | [
"DDInter511",
"DDInter1331"
] | Desvenlafaxine | Olodaterol | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
643,
24,
144
]
],
[
[
643,
63,
1445
],
[
1445,
24,
144
]
],
[
[
643,
64,
121
],
[
121,
24,
144
]
],
[
[
643,
24,
468
],
[
468,
2... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Desvenlafaxine may lead to a major life threatening interaction when taken with Fenfluramine and F... |
DB00704 | DB01048 | 267 | 764 | [
"DDInter1263",
"DDInter1"
] | Naltrexone | Abacavir | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir. | Moderate | 1 | [
[
[
267,
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[
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],
[
[
267,
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[
912,
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[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abacavir"
]
],
[
[
"Naltrexone",
"{u} (Compound) binds {v} (Gene)",
"UGT1A1"
],
[
"UGT1A1",
"{u} (Gene) is bound by {v} (Compound)",
... | Naltrexone (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Abacavir (Compound)
Naltrexone (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Abacavir (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when ... |
DB00635 | DB00991 | 1,573 | 97 | [
"DDInter1515",
"DDInter1358"
] | Prednisone | Oxaprozin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
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[
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1274,
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[
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1573,
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],
[
307,
1... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that coul... |
DB06650 | DB10276 | 1,500 | 1,624 | [
"DDInter1324",
"DDInter1623"
] | Ofatumumab | Rotavirus vaccine | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1500,
25,
1624
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],
[
[
1500,
25,
375
],
[
375,
25,
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[
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],
[
58,
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],
[
[
1500,
24,
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],
[
270,
... | [
[
[
"Ofatumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Ofatumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
],
[
"Certolizum... | Ofatumumab may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may lead to a major life threatening interaction when taken with Rotavirus vaccine
Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may ... |
DB00851 | DB08880 | 611 | 1,510 | [
"DDInter463",
"DDInter1771"
] | Dacarbazine | Teriflunomide | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
611,
25,
1510
]
],
[
[
611,
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],
[
1461,
23,
1510
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[
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221
],
[
221,
63,
1510
]
],
[
[
611,
24,
1136
],
[
1136,
... | [
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 an... |
DB06779 | DB15233 | 365 | 1,650 | [
"DDInter470",
"DDInter142"
] | Dalteparin | Avapritinib | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
365,
25,
1650
]
],
[
[
365,
63,
557
],
[
557,
24,
1650
]
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[
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365,
24,
738
],
[
738,
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1650
]
],
[
[
365,
64,
1512
],
[
1512,
... | [
[
[
"Dalteparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Dalteparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
],
[
"Deo... | Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid and Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Nirapari... |
DB00738 | DB08907 | 485 | 1,344 | [
"DDInter1420",
"DDInter280"
] | Pentamidine | Canagliflozin | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
485,
24,
1344
]
],
[
[
485,
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],
[
549,
1,
1344
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[
[
485,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
485,
21,
28962
],
[
28962,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Pentamidine (Compound) causes Hyperkalaemia (Side Ef... |
DB00056 | DB08895 | 816 | 976 | [
"DDInter814",
"DDInter1825"
] | Gemtuzumab ozogamicin | Tofacitinib | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
816,
25,
976
]
],
[
[
816,
24,
200
],
[
200,
63,
976
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[
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816,
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1430
],
[
1430,
24,
976
]
],
[
[
816,
25,
1011
],
[
1011,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases wh... |
DB00477 | DB09330 | 216 | 985 | [
"DDInter363",
"DDInter1352"
] | Chlorpromazine | Osimertinib | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
216,
25,
985
]
],
[
[
216,
23,
112
],
[
112,
23,
985
]
],
[
[
216,
24,
480
],
[
480,
24,
985
]
],
[
[
216,
24,
657
],
[
657,
63,... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Chlorpromazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"... | Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol... |
DB01088 | DB01367 | 714 | 1,163 | [
"DDInter908",
"DDInter1572"
] | Iloprost | Rasagiline | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
714,
24,
1163
]
],
[
[
714,
63,
1445
],
[
1445,
24,
1163
]
],
[
[
714,
24,
22
],
[
22,
24,
1163
]
],
[
[
714,
24,
1637
],
[
1637,
... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
[
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and E... |
DB00457 | DB01284 | 1,205 | 1,042 | [
"DDInter1511",
"DDInter1782"
] | Prazosin | Tetracosactide | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1205,
24,
1042
]
],
[
[
1205,
40,
195
],
[
195,
24,
1042
]
],
[
[
1205,
24,
1450
],
[
1450,
63,
1042
]
],
[
[
1205,
63,
1648
],
[
1648... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Prazosin",
"{u} (Compound) resembles {v} (Compound)",
"Terazosin"
],
[
"Terazosin",
"{u} may cause a moderate ... | Prazosin (Compound) resembles Terazosin (Compound) and Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that c... |
DB09080 | DB13139 | 144 | 1,032 | [
"DDInter1331",
"DDInter1063"
] | Olodaterol | Levosalbutamol | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
144,
24,
1032
]
],
[
[
144,
63,
1618
],
[
1618,
24,
1032
]
],
[
[
144,
24,
124
],
[
124,
24,
1032
]
],
[
[
144,
24,
982
],
[
982,
... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
],
... | Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and... |
DB05154 | DB09038 | 740 | 1,450 | [
"DDInter1517",
"DDInter636"
] | Pretomanid | Empagliflozin | Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy re... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
740,
24,
1450
]
],
[
[
740,
25,
1017
],
[
1017,
63,
1450
]
],
[
[
740,
24,
98
],
[
98,
63,
1450
]
],
[
[
740,
25,
129
],
[
129,
... | [
[
[
"Pretomanid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Pretomanid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
],
[
"Lorlati... | Pretomanid may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Pretomanid may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a... |
DB00365 | DB00620 | 839 | 175 | [
"DDInter842",
"DDInter1855"
] | Grepafloxacin | Triamcinolone | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Major | 2 | [
[
[
839,
25,
175
]
],
[
[
839,
25,
1573
],
[
1573,
1,
175
]
],
[
[
839,
24,
617
],
[
617,
40,
175
]
],
[
[
839,
24,
455
],
[
455,
62... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Prednisone",
... | Grepafloxacin may lead to a major life threatening interaction when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compound)
Gre... |
DB01259 | DB12500 | 392 | 283 | [
"DDInter1024",
"DDInter714"
] | Lapatinib | Fedratinib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
392,
24,
283
]
],
[
[
392,
23,
271
],
[
271,
23,
283
]
],
[
[
392,
24,
466
],
[
466,
62,
283
]
],
[
[
392,
25,
351
],
[
351,
23,... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutami... |
DB00773 | DB06372 | 896 | 259 | [
"DDInter702",
"DDInter1594"
] | Etoposide | Rilonacept | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
896,
24,
259
]
],
[
[
896,
63,
1461
],
[
1461,
23,
259
]
],
[
[
896,
24,
0
],
[
0,
24,
259
]
],
[
[
896,
24,
1619
],
[
1619,
63,... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin and Dactinomyc... |
DB08889 | DB08895 | 350 | 976 | [
"DDInter299",
"DDInter1825"
] | Carfilzomib | Tofacitinib | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
350,
25,
976
]
],
[
[
350,
63,
1461
],
[
1461,
23,
976
]
],
[
[
350,
24,
200
],
[
200,
63,
976
]
],
[
[
350,
63,
1252
],
[
1252,
... | [
[
[
"Carfilzomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and C... |
DB00348 | DB09098 | 254 | 98 | [
"DDInter1300",
"DDInter1700"
] | Nitisinone | Somatrem | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
254,
24,
98
]
],
[
[
254,
24,
671
],
[
671,
24,
98
]
],
[
[
254,
24,
159
],
[
159,
63,
98
]
],
[
[
254,
63,
576
],
[
576,
24,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Lar... |
DB00350 | DB09128 | 1,214 | 1,241 | [
"DDInter1226",
"DDInter231"
] | Minoxidil | Brexpiprazole | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
1214,
24,
1241
]
],
[
[
1214,
24,
549
],
[
549,
24,
1241
]
],
[
[
1214,
24,
407
],
[
407,
63,
1241
]
],
[
[
1214,
24,
593
],
[
593,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opiu... |
DB00726 | DB11130 | 1,164 | 407 | [
"DDInter1876",
"DDInter1344"
] | Trimipramine | Opium | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1164,
24,
407
]
],
[
[
1164,
24,
662
],
[
662,
24,
407
]
],
[
[
1164,
35,
104
],
[
104,
24,
407
]
],
[
[
1164,
1,
576
],
[
576,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Trimipramine (Compound) resembles Methdilazine (Compound) and Trimipramine may cause a moderate interaction t... |
DB01591 | DB11978 | 667 | 124 | [
"DDInter1696",
"DDInter822"
] | Solifenacin | Glasdegib | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
667,
24,
124
]
],
[
[
667,
62,
112
],
[
112,
23,
124
]
],
[
[
667,
63,
475
],
[
475,
24,
124
]
],
[
[
667,
24,
98
],
[
98,
24,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Solifenacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Solifenacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morph... |
DB00316 | DB00501 | 474 | 752 | [
"DDInter14",
"DDInter380"
] | Acetaminophen | Cimetidine | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
474,
23,
752
]
],
[
[
474,
6,
4973
],
[
4973,
45,
752
]
],
[
[
474,
21,
29062
],
[
29062,
60,
752
]
],
[
[
474,
24,
126
],
[
126,
... | [
[
[
"Acetaminophen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Acetaminophen",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Acetaminophen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)
Acetaminophen (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Cimetidine (Compound)
Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Warfarin... |
DB00072 | DB10343 | 550 | 962 | [
"DDInter1846",
"DDInter160"
] | Trastuzumab | Bacillus calmette-guerin substrain tice live antigen | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
550,
25,
962
]
],
[
[
550,
64,
1057
],
[
1057,
25,
962
]
],
[
[
550,
24,
270
],
[
270,
64,
962
]
],
[
[
550,
24,
1362
],
[
1362,
... | [
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Trastuzumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ocreliz... |
DB00245 | DB00427 | 357 | 1,233 | [
"DDInter181",
"DDInter1879"
] | Benzatropine | Triprolidine | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
357,
24,
1233
]
],
[
[
357,
40,
11268
],
[
11268,
40,
1233
]
],
[
[
357,
6,
12523
],
[
12523,
45,
1233
]
],
[
[
357,
1,
358
],
[
358,
... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Benzatropine",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Compound... | Benzatropine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Triprolidine (Compound)
Benzatropine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Benzatropine (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate intera... |
DB00570 | DB01045 | 147 | 463 | [
"DDInter1936",
"DDInter1590"
] | Vinblastine | Rifampicin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
147,
24,
463
]
],
[
[
147,
24,
690
],
[
690,
40,
463
]
],
[
[
147,
6,
5912
],
[
5912,
45,
463
]
],
[
[
147,
63,
1101
],
[
1101,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Vinblastine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Rifampicin (Compound)
Vinblastine may cause a moderate interaction that could exacerbate d... |
DB00321 | DB00486 | 21 | 1,614 | [
"DDInter78",
"DDInter1253"
] | Amitriptyline | Nabilone | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
21,
24,
1614
]
],
[
[
21,
24,
530
],
[
530,
1,
1614
]
],
[
[
21,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
21,
24,
999
],
[
999,
2... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Amitriptyline (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Amitriptyline may ... |
DB00374 | DB00575 | 1,061 | 1,020 | [
"DDInter1852",
"DDInter412"
] | Treprostinil | Clonidine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Moderate | 1 | [
[
[
1061,
24,
1020
]
],
[
[
1061,
24,
1512
],
[
1512,
40,
1020
]
],
[
[
1061,
25,
876
],
[
876,
40,
1020
]
],
[
[
1061,
7,
3415
],
[
3415,... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac (Compound) resembles Clonidine (Compound)
Treprostinil may lead to a major life threatening interaction when taken with Tizanidine and Tizanidine (Compound) resembles Clonidine (Compound)
Treprostinil ... |
DB00916 | DB01244 | 112 | 762 | [
"DDInter1202",
"DDInter192"
] | Metronidazole | Bepridil | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Minor | 0 | [
[
[
112,
23,
762
]
],
[
[
112,
62,
675
],
[
675,
40,
762
]
],
[
[
112,
21,
28698
],
[
28698,
60,
762
]
],
[
[
112,
24,
973
],
[
973,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bepridil"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dextropropoxyphene"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Bepridil (Compound)
Metronidazole (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bepridil (Compound)
Metronidazole may cause a mode... |
DB00446 | DB01124 | 597 | 1,411 | [
"DDInter351",
"DDInter1828"
] | Chloramphenicol | Tolbutamide | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
597,
24,
1411
]
],
[
[
597,
24,
959
],
[
959,
40,
1411
]
],
[
[
597,
63,
245
],
[
245,
40,
1411
]
],
[
[
597,
6,
10215
],
[
10215,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide... |
DB04835 | DB09054 | 1,655 | 384 | [
"DDInter1125",
"DDInter905"
] | Maraviroc | Idelalisib | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1655,
25,
384
]
],
[
[
1655,
24,
1618
],
[
1618,
24,
384
]
],
[
[
1655,
63,
305
],
[
305,
24,
384
]
],
[
[
1655,
24,
1619
],
[
1619,
... | [
[
[
"Maraviroc",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
],
[
"Cabozantin... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escher... |
DB05294 | DB11915 | 1,069 | 1,293 | [
"DDInter1917",
"DDInter1909"
] | Vandetanib | Valbenazine | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Major | 2 | [
[
[
1069,
25,
1293
]
],
[
[
1069,
62,
112
],
[
112,
23,
1293
]
],
[
[
1069,
24,
710
],
[
710,
63,
1293
]
],
[
[
1069,
64,
521
],
[
521,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valbenazine"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Bi... |
DB01267 | DB01612 | 519 | 1,637 | [
"DDInter1381",
"DDInter92"
] | Paliperidone | Amyl Nitrite | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
519,
24,
1637
]
],
[
[
519,
64,
475
],
[
475,
24,
1637
]
],
[
[
519,
63,
401
],
[
401,
24,
1637
]
],
[
[
519,
24,
407
],
[
407,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphi... | Paliperidone may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may ... |
DB01115 | DB01234 | 336 | 1,220 | [
"DDInter1291",
"DDInter513"
] | Nifedipine | Dexamethasone | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
336,
24,
1220
]
],
[
[
336,
63,
870
],
[
870,
1,
1220
]
],
[
[
336,
63,
175
],
[
175,
40,
1220
]
],
[
[
336,
24,
617
],
[
617,
4... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00909 | DB11130 | 306 | 407 | [
"DDInter1971",
"DDInter1344"
] | Zonisamide | Opium | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
306,
24,
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]
],
[
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306,
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[
662,
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[
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[
849,
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],
[
[
306,
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516
],
[
516,
24,... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carbinoxamine"
],
[
"Carbinoxamin... | Zonisamide may lead to a major life threatening interaction when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Zonisamide may lead to a major life threatening interaction when taken with Mepyramine and Mepyramine may cause a moderate int... |
DB00196 | DB00640 | 600 | 1,585 | [
"DDInter743",
"DDInter31"
] | Fluconazole | Adenosine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Moderate | 1 | [
[
[
600,
24,
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],
[
[
600,
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[
372,
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[
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28676
],
[
28676,
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1585
]
],
[
[
600,
24,
578
],
[
578,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Adenosine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Adenosine (Compound)
Fluconazole (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Adenosine (Compound)
Fluconazole may cause a moderate inter... |
DB06772 | DB12825 | 310 | 1,375 | [
"DDInter259",
"DDInter1032"
] | Cabazitaxel | Lefamulin | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
310,
24,
1375
]
],
[
[
310,
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112
],
[
112,
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1375
]
],
[
[
310,
63,
309
],
[
309,
24,
1375
]
],
[
[
310,
25,
976
],
[
976,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and ... |
DB00601 | DB01191 | 453 | 1,039 | [
"DDInter1073",
"DDInter518"
] | Linezolid | Dexfenfluramine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
453,
25,
1039
]
],
[
[
453,
63,
1061
],
[
1061,
24,
1039
]
],
[
[
453,
24,
1144
],
[
1144,
24,
1039
]
],
[
[
453,
24,
1311
],
[
1311,
... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Trepr... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide an... |
DB01023 | DB11348 | 409 | 1,065 | [
"DDInter716",
"DDInter279"
] | Felodipine | Calcium Phosphate | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
409,
24,
1065
]
],
[
[
409,
1,
336
],
[
336,
24,
1065
]
],
[
[
409,
40,
854
],
[
854,
24,
1065
]
],
[
[
409,
1,
336
],
[
336,
1,... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Felodipine",
"{u} (Compound) resembles {v} (Compound)",
"Nifedipine"
],
[
"Nifedipine",
"{u} may cause a ... | Felodipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Felodipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Calc... |
DB00708 | DB11186 | 1,454 | 1,609 | [
"DDInter1718",
"DDInter1427"
] | Sufentanil | Pentoxyverine | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1454,
24,
1609
]
],
[
[
1454,
24,
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],
[
104,
24,
1609
]
],
[
[
1454,
63,
999
],
[
999,
24,
1609
]
],
[
[
1454,
1,
1322
],
[
1322,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazi... |
DB00604 | DB01165 | 1,425 | 1,539 | [
"DDInter385",
"DDInter1325"
] | Cisapride | Ofloxacin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
1425,
25,
1539
]
],
[
[
1425,
64,
1176
],
[
1176,
1,
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],
[
[
1425,
25,
956
],
[
956,
40,
1539
]
],
[
[
1425,
25,
246
],
[
246,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} ... | Cisapride may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Cisapride may lead to a major life threatening interaction when taken with Norfloxacin and Norfloxacin (Compound) resembles Ofloxacin (Compound)
Cisapride may lead to a majo... |
DB00843 | DB11363 | 479 | 1,276 | [
"DDInter583",
"DDInter39"
] | Donepezil | Alectinib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
479,
24,
1276
]
],
[
[
479,
24,
61
],
[
61,
24,
1276
]
],
[
[
479,
62,
1424
],
[
1424,
24,
1276
]
],
[
[
479,
63,
322
],
[
322,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Donepezil may cause a minor interaction that can limit clinical effects when taken with Quinine and Quinine may ... |
DB00911 | DB06273 | 458 | 980 | [
"DDInter1811",
"DDInter1824"
] | Tinidazole | Tocilizumab | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
458,
24,
980
]
],
[
[
458,
24,
309
],
[
309,
24,
980
]
],
[
[
458,
24,
110
],
[
110,
63,
980
]
],
[
[
458,
63,
467
],
[
467,
24,... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedoti... |
DB00334 | DB01211 | 867 | 609 | [
"DDInter1326",
"DDInter393"
] | Olanzapine | Clarithromycin | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
867,
24,
609
]
],
[
[
867,
6,
4973
],
[
4973,
45,
609
]
],
[
[
867,
7,
18592
],
[
18592,
46,
609
]
],
[
[
867,
63,
600
],
[
600,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Olanzapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Olanzapine (Compound) upregulates TMEM110 (Gene) and TMEM110 (Gene) is upregulated by Clarithromycin (Compound)
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluco... |
DB00938 | DB01069 | 455 | 401 | [
"DDInter1635",
"DDInter1533"
] | Salmeterol | Promethazine | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
455,
24,
401
]
],
[
[
455,
24,
1264
],
[
1264,
63,
401
]
],
[
[
455,
63,
939
],
[
939,
24,
401
]
],
[
[
455,
21,
28787
],
[
28787,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphe... |
DB00424 | DB00477 | 19 | 216 | [
"DDInter896",
"DDInter363"
] | Hyoscyamine | Chlorpromazine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Moderate | 1 | [
[
[
19,
24,
216
]
],
[
[
19,
24,
1178
],
[
1178,
1,
216
]
],
[
[
19,
24,
662
],
[
662,
63,
216
]
],
[
[
19,
24,
684
],
[
684,
40,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpromazine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Chlorpromazine (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate ... |
DB00059 | DB06589 | 1,560 | 1,250 | [
"DDInter1404",
"DDInter1400"
] | Pegaspargase | Pazopanib | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1560,
24,
1250
]
],
[
[
1560,
24,
1247
],
[
1247,
23,
1250
]
],
[
[
1560,
24,
1151
],
[
1151,
24,
1250
]
],
[
[
1560,
24,
1270
],
[
12... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sunitini... |
DB00563 | DB00879 | 663 | 1,279 | [
"DDInter1174",
"DDInter637"
] | Methotrexate | Emtricitabine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse t... | Moderate | 1 | [
[
[
663,
24,
1279
]
],
[
[
663,
63,
141
],
[
141,
40,
1279
]
],
[
[
663,
21,
28666
],
[
28666,
60,
1279
]
],
[
[
663,
63,
322
],
[
322,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emtricitabine"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) resembles Emtricitabine (Compound)
Methotrexate (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Emtricitabine (Compound)
Meth... |
DB00488 | DB14783 | 196 | 287 | [
"DDInter57",
"DDInter574"
] | Altretamine | Diroximel fumarate | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
196,
24,
287
]
],
[
[
196,
63,
599
],
[
599,
24,
287
]
],
[
[
196,
24,
270
],
[
270,
24,
287
]
],
[
[
196,
25,
770
],
[
770,
24,... | [
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
... | Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizum... |
DB01168 | DB08895 | 1,053 | 976 | [
"DDInter1526",
"DDInter1825"
] | Procarbazine | Tofacitinib | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1053,
25,
976
]
],
[
[
1053,
63,
1461
],
[
1461,
23,
976
]
],
[
[
1053,
24,
200
],
[
200,
63,
976
]
],
[
[
1053,
63,
1020
],
[
1020,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and... |
DB09038 | DB11255 | 1,450 | 1,371 | [
"DDInter636",
"DDInter374"
] | Empagliflozin | Chromium picolinate | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
1450,
24,
1371
]
],
[
[
1450,
63,
245
],
[
245,
24,
1371
]
],
[
[
1450,
24,
1296
],
[
1296,
24,
1371
]
],
[
[
1450,
63,
245
],
[
245,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Insu... |
DB00703 | DB09038 | 997 | 1,450 | [
"DDInter1167",
"DDInter636"
] | Methazolamide | Empagliflozin | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
997,
24,
1450
]
],
[
[
997,
24,
659
],
[
659,
63,
1450
]
],
[
[
997,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
997,
24,
1486
],
[
1486,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil... |
DB01072 | DB09073 | 915 | 951 | [
"DDInter129",
"DDInter1379"
] | Atazanavir | Palbociclib | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
915,
25,
951
]
],
[
[
915,
25,
1476
],
[
1476,
63,
951
]
],
[
[
915,
24,
710
],
[
710,
63,
951
]
],
[
[
915,
64,
467
],
[
467,
2... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
"{u} ... | Atazanavir may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Binimetinib may cau... |
DB00286 | DB00673 | 380 | 723 | [
"DDInter439",
"DDInter112"
] | Conjugated estrogens | Aprepitant | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
380,
24,
723
]
],
[
[
380,
6,
7950
],
[
7950,
45,
723
]
],
[
[
380,
10,
11579
],
[
11579,
49,
723
]
],
[
[
380,
21,
28890
],
[
28890,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound... | Conjugated estrogens (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Aprepitant (Compound)
Conjugated estrogens (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is palliated by Aprepitant (Compound)
Conjugated estrogens (Compound) causes Myocardial infarction (Side Effect) and Myoca... |
DB00902 | DB01235 | 104 | 1,191 | [
"DDInter1168",
"DDInter1054"
] | Methdilazine | Levodopa | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
104,
24,
1191
]
],
[
[
104,
24,
584
],
[
584,
1,
1191
]
],
[
[
104,
63,
874
],
[
874,
24,
1191
]
],
[
[
104,
24,
817
],
[
817,
4... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonordefrin"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin and Levonordefrin (Compound) resembles Levodopa (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction ... |
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