drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01021 | DB01309 | 674 | 1,254 | [
"DDInter1861",
"DDInter933"
] | Trichlormethiazide | Insulin glulisine | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
674,
24,
1254
]
],
[
[
674,
62,
1669
],
[
1669,
24,
1254
]
],
[
[
674,
63,
167
],
[
167,
24,
1254
]
],
[
[
674,
24,
1220
],
[
1220,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Minocy... | Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Minocycline and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00791 | DB01044 | 132 | 246 | [
"DDInter1902",
"DDInter809"
] | Uracil mustard | Gatifloxacin | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Minor | 0 | [
[
[
132,
23,
246
]
],
[
[
132,
62,
1176
],
[
1176,
1,
246
]
],
[
[
132,
23,
872
],
[
872,
40,
246
]
],
[
[
132,
1,
970
],
[
970,
23,... | [
[
[
"Uracil mustard",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Uracil mustard",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Moxifloxacin"
],
... | Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Gatiflox... |
DB06822 | DB09075 | 802 | 498 | [
"DDInter1812",
"DDInter621"
] | Tinzaparin | Edoxaban | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
802,
25,
498
]
],
[
[
802,
23,
944
],
[
944,
62,
498
]
],
[
[
802,
24,
1004
],
[
1004,
63,
498
]
],
[
[
802,
24,
41
],
[
41,
24,... | [
[
[
"Tinzaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Tinzaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Tinzaparin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl ... |
DB00275 | DB01050 | 217 | 848 | [
"DDInter1330",
"DDInter900"
] | Olmesartan | Ibuprofen | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
217,
24,
848
]
],
[
[
217,
24,
1053
],
[
1053,
1,
848
]
],
[
[
217,
21,
28773
],
[
28773,
60,
848
]
],
[
[
217,
1,
240
],
[
240,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
[
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Olmesartan (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Olmesartan (Compound) rese... |
DB05812 | DB12245 | 1,374 | 823 | [
"DDInter8",
"DDInter1863"
] | Abiraterone | Triclabendazole | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1374,
24,
823
]
],
[
[
1374,
62,
1247
],
[
1247,
23,
823
]
],
[
[
1374,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1374,
63,
1010
],
[
1010,... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Fostem... |
DB00673 | DB01129 | 723 | 379 | [
"DDInter112",
"DDInter1559"
] | Aprepitant | Rabeprazole | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
723,
24,
379
]
],
[
[
723,
63,
1215
],
[
1215,
40,
379
]
],
[
[
723,
6,
8374
],
[
8374,
45,
379
]
],
[
[
723,
21,
29267
],
[
29267,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rabeprazole (Compound)
Aprepitant (Compound) causes Alanine aminotransferase increa... |
DB01364 | DB06701 | 22 | 1,177 | [
"DDInter650",
"DDInter521"
] | Ephedrine | Dexmethylphenidate | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer s... | Moderate | 1 | [
[
[
22,
24,
1177
]
],
[
[
22,
63,
895
],
[
895,
1,
1177
]
],
[
[
22,
40,
904
],
[
904,
1,
1177
]
],
[
[
22,
6,
7390
],
[
7390,
45,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexmethylphenidate"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylphenidate"
... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Methylphenidate and Methylphenidate (Compound) resembles Dexmethylphenidate (Compound)
Ephedrine (Compound) resembles Cyclandelate (Compound) and Cyclandelate (Compound) resembles Dexmethylphenidate (Compound)
Ephedrine (Compound)... |
DB00352 | DB06674 | 482 | 908 | [
"DDInter1814",
"DDInter837"
] | Tioguanine | Golimumab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
482,
25,
908
]
],
[
[
482,
63,
1461
],
[
1461,
23,
908
]
],
[
[
482,
63,
268
],
[
268,
24,
908
]
],
[
[
482,
24,
651
],
[
651,
2... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and ... |
DB00252 | DB12015 | 362 | 1,033 | [
"DDInter1460",
"DDInter53"
] | Phenytoin | Alpelisib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Major | 2 | [
[
[
362,
25,
1033
]
],
[
[
362,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
362,
24,
1254
],
[
1254,
24,
1033
]
],
[
[
362,
25,
951
],
[
951,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alpelisib"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ca... | Phenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may... |
DB00001 | DB09293 | 1,578 | 116 | [
"DDInter1037",
"DDInter954"
] | Lepirudin | Iodide I-131 | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1578,
24,
116
]
],
[
[
1578,
24,
1004
],
[
1004,
63,
116
]
],
[
[
1578,
25,
365
],
[
365,
24,
116
]
],
[
[
1578,
25,
235
],
[
235,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
],
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Lepirudin may lead to a major life threatening interaction when taken with Dalteparin and Daltepa... |
DB00574 | DB01067 | 121 | 959 | [
"DDInter717",
"DDInter826"
] | Fenfluramine | Glipizide | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
121,
24,
959
]
],
[
[
121,
63,
245
],
[
245,
40,
959
]
],
[
[
121,
24,
1411
],
[
1411,
1,
959
]
],
[
[
121,
24,
1674
],
[
1674,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Comp... |
DB01229 | DB01235 | 973 | 1,191 | [
"DDInter1378",
"DDInter1054"
] | Paclitaxel (protein-bound) | Levodopa | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
973,
24,
1191
]
],
[
[
973,
18,
1918
],
[
1918,
57,
1191
]
],
[
[
973,
21,
28936
],
[
28936,
60,
1191
]
],
[
[
973,
63,
63
],
[
63,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Paclitaxel",
"{u} (Compound) downregulates {v} (Gene)",
"PCNA"
],
[
"PCNA",
"{u} (Gene) is downregulated by {v} (C... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Paclitaxel (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Levodopa (Compound)
Paclitaxel (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Levodopa (Comp... |
DB01210 | DB08865 | 668 | 1,593 | [
"DDInter1050",
"DDInter448"
] | Levobunolol (ophthalmic) | Crizotinib | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
668,
24,
1593
]
],
[
[
668,
7,
18110
],
[
18110,
46,
1593
]
],
[
[
668,
18,
7385
],
[
7385,
57,
1593
]
],
[
[
668,
21,
28771
],
[
2877... | [
[
[
"Levobunolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Levobunolol",
"{u} (Compound) upregulates {v} (Gene)",
"ST6GALNAC2"
],
[
"ST6GALNAC2",
"{u} (Gene) is upregulat... | Levobunolol may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib
Levobunolol (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Crizotinib (Compound)
Levobunolol (Compound) downregulates MTERF3 (Gene) and MTERF3 (Gene) is downregulated by Crizotinib (C... |
DB00315 | DB00889 | 767 | 1,133 | [
"DDInter1969",
"DDInter840"
] | Zolmitriptan | Granisetron | Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptan... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
767,
25,
1133
]
],
[
[
767,
18,
10375
],
[
10375,
57,
1133
]
],
[
[
767,
21,
29282
],
[
29282,
60,
1133
]
],
[
[
767,
24,
1619
],
[
16... | [
[
[
"Zolmitriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Zolmitriptan",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated by {v} (Compo... | Zolmitriptan (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Granisetron (Compound)
Zolmitriptan (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Granisetron (Compound)
Zolmitriptan may cause a moderate interaction that could exacerbate diseases when take... |
DB00754 | DB01097 | 157 | 1,377 | [
"DDInter696",
"DDInter1033"
] | Ethotoin | Leflunomide | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
157,
25,
1377
]
],
[
[
157,
21,
28864
],
[
28864,
60,
1377
]
],
[
[
157,
63,
126
],
[
126,
24,
1377
]
],
[
[
157,
24,
852
],
[
852,
... | [
[
[
"Ethotoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Ethotoin",
"{u} (Compound) causes {v} (Side Effect)",
"Erythema multiforme"
],
[
"Erythema multiforme",
"{u} (Side Effect) is ca... | Ethotoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Leflunomide (Compound)
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken... |
DB01259 | DB11967 | 392 | 710 | [
"DDInter1024",
"DDInter210"
] | Lapatinib | Binimetinib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
392,
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],
[
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],
[
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[
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],
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],
[
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[
1593,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
],
[
"Delavirdin... | Lapatinib may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine and Valbenazine may cau... |
DB00580 | DB06209 | 311 | 256 | [
"DDInter1910",
"DDInter1508"
] | Valdecoxib | Prasugrel | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
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24,
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[
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[
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],
[
305,
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]
],
[
[
311,
24,
1479
],
[
1479,
2... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia... |
DB00250 | DB08870 | 10 | 850 | [
"DDInter475",
"DDInter228"
] | Dapsone | Brentuximab vedotin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
10,
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850
]
],
[
[
10,
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],
[
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850
]
],
[
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10,
24,
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],
[
1033,
63,
850
]
],
[
[
10,
63,
367
],
[
367,
24,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and ... |
DB00305 | DB08904 | 377 | 375 | [
"DDInter1232",
"DDInter342"
] | Mitomycin | Certolizumab pegol | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
377,
25,
375
]
],
[
[
377,
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23,
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377,
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200
],
[
200,
63,
375
]
],
[
[
377,
63,
66
],
[
66,
24,... | [
[
[
"Mitomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitam... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans an... |
DB00209 | DB08815 | 352 | 154 | [
"DDInter1886",
"DDInter1104"
] | Trospium | Lurasidone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
352,
24,
154
]
],
[
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352,
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[
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[
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352,
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],
[
100,
24,
154
]
],
[
[
352,
35,
262
],
[
262,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Trospium",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) is caus... | Trospium (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Lurasidone (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00800 | DB01075 | 572 | 1,376 | [
"DDInter720",
"DDInter569"
] | Fenoldopam | Diphenhydramine | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
572,
24,
1376
]
],
[
[
572,
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],
[
401,
24,
1376
]
],
[
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572,
21,
28921
],
[
28921,
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1376
]
],
[
[
572,
63,
530
],
[
530,
... | [
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Fenoldopam (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Diphenhyd... |
DB00087 | DB00738 | 599 | 485 | [
"DDInter41",
"DDInter1420"
] | Alemtuzumab | Pentamidine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
599,
24,
485
]
],
[
[
599,
24,
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],
[
1272,
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]
],
[
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599,
24,
322
],
[
322,
24,
485
]
],
[
[
599,
24,
39
],
[
39,
64,... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and E... |
DB00242 | DB09389 | 1,064 | 517 | [
"DDInter392",
"DDInter1315"
] | Cladribine | Norgestrel | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1064,
24,
517
]
],
[
[
1064,
64,
581
],
[
581,
24,
517
]
],
[
[
1064,
25,
908
],
[
908,
24,
517
]
],
[
[
1064,
24,
129
],
[
129,
... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
"Infliximab... | Cladribine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Cladribine may lead to a major life threatening interaction when taken with Golimumab and Golimumab may cause a moderate intera... |
DB06414 | DB13074 | 655 | 877 | [
"DDInter703",
"DDInter1110"
] | Etravirine | Macimorelin | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
655,
24,
877
]
],
[
[
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63,
112
],
[
112,
23,
877
]
],
[
[
655,
24,
1320
],
[
1320,
24,
877
]
],
[
[
655,
25,
913
],
[
913,
2... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB00059 | DB00330 | 1,560 | 238 | [
"DDInter1404",
"DDInter689"
] | Pegaspargase | Ethambutol | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Moderate | 1 | [
[
[
1560,
24,
238
]
],
[
[
1560,
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],
[
1057,
24,
238
]
],
[
[
1560,
24,
467
],
[
467,
63,
238
]
],
[
[
1560,
63,
1451
],
[
1451,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethambutol"
]
],
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
],
[
"Etaner... | Pegaspargase may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may ... |
DB00981 | DB01035 | 1,528 | 1,401 | [
"DDInter1463",
"DDInter1524"
] | Physostigmine (ophthalmic) | Procainamide | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | A derivative of procaine with less CNS action. | Moderate | 1 | [
[
[
1528,
24,
1401
]
],
[
[
1528,
6,
5765
],
[
5765,
45,
1401
]
],
[
[
1528,
21,
28658
],
[
28658,
60,
1401
]
],
[
[
1528,
24,
770
],
[
77... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procainamide"
]
],
[
[
"Physostigmine",
"{u} (Compound) binds {v} (Gene)",
"ACHE"
],
[
"ACHE",
"{u} (Gene) is bound by {v} (Compoun... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Procainamide
Physostigmine (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Procainamide (Compound)
Physostigmine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Procainamide (Compound)... |
DB00552 | DB01041 | 1,238 | 770 | [
"DDInter1425",
"DDInter1789"
] | Pentostatin | Thalidomide | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
1238,
25,
770
]
],
[
[
1238,
5,
11555
],
[
11555,
44,
770
]
],
[
[
1238,
21,
29598
],
[
29598,
60,
770
]
],
[
[
1238,
24,
4
],
[
4,
... | [
[
[
"Pentostatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Pentostatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treate... | Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Pentostatin (Compound) causes Cellulitis (Side Effect) and Cellulitis (Side Effect) is caused by Thalidomide (Compound)
Pentostatin may cause a moderate interaction that could exacerbate dise... |
DB00557 | DB05294 | 252 | 1,069 | [
"DDInter895",
"DDInter1917"
] | Hydroxyzine | Vandetanib | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
252,
25,
1069
]
],
[
[
252,
21,
28930
],
[
28930,
60,
1069
]
],
[
[
252,
23,
112
],
[
112,
23,
1069
]
],
[
[
252,
24,
659
],
[
659,
... | [
[
[
"Hydroxyzine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) causes {v} (Side Effect)",
"Depressed level of consciousness"
],
[
"Depressed level of consciousness",... | Hydroxyzine (Compound) causes Depressed level of consciousness (Side Effect) and Depressed level of consciousness (Side Effect) is caused by Vandetanib (Compound)
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that ... |
DB00515 | DB01095 | 589 | 671 | [
"DDInter387",
"DDInter769"
] | Cisplatin | Fluvastatin | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Moderate | 1 | [
[
[
589,
24,
671
]
],
[
[
589,
24,
788
],
[
788,
40,
671
]
],
[
[
589,
24,
14
],
[
14,
63,
671
]
],
[
[
589,
6,
7603
],
[
7603,
45,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction tha... |
DB01168 | DB06207 | 1,053 | 910 | [
"DDInter1526",
"DDInter1667"
] | Procarbazine | Silodosin | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
1053,
24,
910
]
],
[
[
1053,
21,
28921
],
[
28921,
60,
910
]
],
[
[
1053,
64,
1264
],
[
1264,
24,
910
]
],
[
[
1053,
63,
999
],
[
999,... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Procarbazine",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is c... | Procarbazine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Silodosin (Compound)
Procarbazine may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Silodosin
Procarbazine ma... |
DB00372 | DB00980 | 999 | 969 | [
"DDInter1793",
"DDInter1564"
] | Thiethylperazine | Ramelteon | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
999,
24,
969
]
],
[
[
999,
24,
100
],
[
100,
24,
969
]
],
[
[
999,
63,
1242
],
[
1242,
24,
969
]
],
[
[
999,
24,
1376
],
[
1376,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00563 | DB00618 | 663 | 1,572 | [
"DDInter1174",
"DDInter498"
] | Methotrexate | Demeclocycline | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Moderate | 1 | [
[
[
663,
24,
1572
]
],
[
[
663,
24,
1620
],
[
1620,
1,
1572
]
],
[
[
663,
63,
964
],
[
964,
1,
1572
]
],
[
[
663,
24,
1669
],
[
1669,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Demeclocycline (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Demecloc... |
DB00734 | DB05812 | 1,664 | 1,374 | [
"DDInter1605",
"DDInter8"
] | Risperidone | Abiraterone | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1664,
24,
1374
]
],
[
[
1664,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
1664,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
1664,
23,
112
],
[
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Risperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Risperidone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Risperidone (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidaz... |
DB00398 | DB11986 | 79 | 484 | [
"DDInter1702",
"DDInter648"
] | Sorafenib | Entrectinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
79,
24,
484
]
],
[
[
79,
23,
1247
],
[
1247,
23,
484
]
],
[
[
79,
24,
1539
],
[
1539,
24,
484
]
],
[
[
79,
24,
180
],
[
180,
63,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Sorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Sorafenib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and ... |
DB00195 | DB00277 | 726 | 1,031 | [
"DDInter198",
"DDInter1791"
] | Betaxolol (ophthalmic) | Theophylline | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Major | 2 | [
[
[
726,
25,
1031
]
],
[
[
726,
25,
746
],
[
746,
40,
1031
]
],
[
[
726,
6,
7950
],
[
7950,
45,
1031
]
],
[
[
726,
21,
28666
],
[
28666,
... | [
[
[
"Betaxolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Theophylline"
]
],
[
[
"Betaxolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dyphylline"
],
[
"Dyphylline",
"{u} (... | Betaxolol may lead to a major life threatening interaction when taken with Theophylline
Betaxolol may lead to a major life threatening interaction when taken with Dyphylline and Dyphylline (Compound) resembles Theophylline (Compound)
Betaxolol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Theophylline (C... |
DB06782 | DB15617 | 1,575 | 174 | [
"DDInter563",
"DDInter724"
] | Dimercaprol | Ferric derisomaltose | Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the... | Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide. Iron deficiency results when iron intake, iron stores, and loss of iron from the body do not adequately support production of erythrocytes, also known as red blood cells. Though it is generally considered non life-threa... | Major | 2 | [
[
[
1575,
25,
174
]
],
[
[
1575,
25,
428
],
[
428,
24,
174
]
],
[
[
1575,
64,
1596
],
[
1596,
24,
174
]
],
[
[
1575,
25,
428
],
[
428,
... | [
[
[
"Dimercaprol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ferric derisomaltose"
]
],
[
[
"Dimercaprol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ferrous fumarate"
],
[
"Ferrous... | Dimercaprol may lead to a major life threatening interaction when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ferric derisomaltose
Dimercaprol may lead to a major life threatening interaction when taken with Iron and Iron may cause a m... |
DB00227 | DB00619 | 1,463 | 1,419 | [
"DDInter1098",
"DDInter909"
] | Lovastatin | Imatinib | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
1463,
24,
1419
]
],
[
[
1463,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
1463,
18,
5527
],
[
5527,
57,
1419
]
],
[
[
1463,
21,
28762
],
[
28... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Lovastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Lovastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Lovastatin (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Imatinib (Compound)
Lovastatin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Imatinib (Compound)
Lovastatin may... |
DB06209 | DB06810 | 256 | 397 | [
"DDInter1508",
"DDInter1484"
] | Prasugrel | Plicamycin | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Major | 2 | [
[
[
256,
25,
397
]
],
[
[
256,
23,
539
],
[
539,
62,
397
]
],
[
[
256,
63,
885
],
[
885,
24,
397
]
],
[
[
256,
24,
643
],
[
643,
24,... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plicamycin"
]
],
[
[
"Prasugrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Prasugrel may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Plicamycin
Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol m... |
DB00559 | DB01259 | 152 | 392 | [
"DDInter223",
"DDInter1024"
] | Bosentan | Lapatinib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
152,
24,
392
]
],
[
[
152,
6,
8374
],
[
8374,
45,
392
]
],
[
[
152,
18,
5795
],
[
5795,
46,
392
]
],
[
[
152,
21,
29429
],
[
29429,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Bosentan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Bosentan (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Lapatinib (Compound)
Bosentan (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
B... |
DB00930 | DB08880 | 166 | 1,510 | [
"DDInter432",
"DDInter1771"
] | Colesevelam | Teriflunomide | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
166,
25,
1510
]
],
[
[
166,
63,
1031
],
[
1031,
24,
1510
]
],
[
[
166,
24,
1220
],
[
1220,
25,
1510
]
],
[
[
166,
25,
1096
],
[
1096,
... | [
[
[
"Colesevelam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
[
"The... | Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Dexamethason... |
DB01050 | DB08822 | 848 | 911 | [
"DDInter900",
"DDInter156"
] | Ibuprofen | Azilsartan medoxomil | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
848,
24,
911
]
],
[
[
848,
63,
217
],
[
217,
1,
911
]
],
[
[
848,
21,
29081
],
[
29081,
60,
911
]
],
[
[
848,
24,
1220
],
[
1220,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
],
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Ibuprofen (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Azilsartan medoxomil (Compound)
Ibuprofen may cause a mo... |
DB01182 | DB11569 | 371 | 1,093 | [
"DDInter1534",
"DDInter1003"
] | Propafenone | Ixekizumab | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
371,
24,
1093
]
],
[
[
371,
62,
608
],
[
608,
24,
1093
]
],
[
[
371,
24,
1683
],
[
1683,
24,
1093
]
],
[
[
371,
40,
704
],
[
704,
... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Propafenone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
... | Propafenone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekin... |
DB00461 | DB06605 | 598 | 1,409 | [
"DDInter1254",
"DDInter108"
] | Nabumetone | Apixaban | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
598,
25,
1409
]
],
[
[
598,
6,
7950
],
[
7950,
45,
1409
]
],
[
[
598,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
598,
63,
1560
],
[
1560,... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Nabumetone",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Apixaban"... | Nabumetone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Apixaban (Compound)
Nabumetone (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegasparga... |
DB08904 | DB09073 | 375 | 951 | [
"DDInter342",
"DDInter1379"
] | Certolizumab pegol | Palbociclib | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
375,
25,
951
]
],
[
[
375,
24,
496
],
[
496,
63,
951
]
],
[
[
375,
25,
1476
],
[
1476,
63,
951
]
],
[
[
375,
63,
1454
],
[
1454,
... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
... | Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Certolizumab pegol may lead to a major life threatening interaction when taken with B... |
DB00749 | DB00975 | 59 | 1,317 | [
"DDInter699",
"DDInter573"
] | Etodolac | Dipyridamole | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
59,
24,
1317
]
],
[
[
59,
21,
28748
],
[
28748,
60,
1317
]
],
[
[
59,
24,
714
],
[
714,
63,
1317
]
],
[
[
59,
63,
1167
],
[
1167,
... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Etodolac",
"{u} (Compound) causes {v} (Side Effect)",
"Vertigo"
],
[
"Vertigo",
"{u} (Side Effect) is caused by ... | Etodolac (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Dipyridamole (Compound)
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Etod... |
DB00472 | DB04932 | 758 | 1,564 | [
"DDInter758",
"DDInter491"
] | Fluoxetine | Defibrotide | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
758,
24,
1564
]
],
[
[
758,
25,
1039
],
[
1039,
24,
1564
]
],
[
[
758,
24,
714
],
[
714,
24,
1564
]
],
[
[
758,
1,
109
],
[
109,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"Dexf... | Fluoxetine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may... |
DB00078 | DB00686 | 1,172 | 383 | [
"DDInter898",
"DDInter1424"
] | Ibritumomab tiuxetan | Pentosan polysulfate | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Moderate | 1 | [
[
[
1172,
24,
383
]
],
[
[
1172,
25,
714
],
[
714,
63,
383
]
],
[
[
1172,
64,
20
],
[
20,
24,
383
]
],
[
[
1172,
25,
1061
],
[
1061,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloprost"
... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Tenecteplase and Tenectep... |
DB00247 | DB08899 | 1,131 | 129 | [
"DDInter1194",
"DDInter649"
] | Methysergide | Enzalutamide | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1131,
24,
129
]
],
[
[
1131,
24,
918
],
[
918,
1,
129
]
],
[
[
1131,
21,
28921
],
[
28921,
60,
129
]
],
[
[
1131,
24,
1320
],
[
1320,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Methysergide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Enzalutamide (Compound)
Methysergide may cause a moderat... |
DB06704 | DB10583 | 247 | 949 | [
"DDInter952",
"DDInter415"
] | Iobenguane (I-131) | Clostridium tetani toxoid antigen (formaldehyde inactivated) | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
247,
24,
949
]
],
[
[
247,
7,
6952
],
[
6952,
46,
77
],
[
77,
24,
949
]
],
[
[
247,
18,
7359
],
[
7359,
57,
147
],
[
147,
24,
... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Iobenguane",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Iobenguane (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exa... |
DB00987 | DB08908 | 1,224 | 713 | [
"DDInter460",
"DDInter564"
] | Cytarabine | Dimethyl fumarate | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1224,
24,
713
]
],
[
[
1224,
24,
996
],
[
996,
24,
713
]
],
[
[
1224,
63,
552
],
[
552,
24,
713
]
],
[
[
1224,
24,
270
],
[
270,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
],
... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Carmustine a... |
DB00586 | DB00685 | 1,512 | 1,299 | [
"DDInter537",
"DDInter1887"
] | Diclofenac | Trovafloxacin | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Moderate | 1 | [
[
[
1512,
24,
1299
]
],
[
[
1512,
24,
872
],
[
872,
40,
1299
]
],
[
[
1512,
63,
1467
],
[
1467,
40,
1299
]
],
[
[
1512,
21,
29028
],
[
290... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Trovafloxacin (Comp... |
DB00041 | DB00060 | 1,648 | 912 | [
"DDInter38",
"DDInter947"
] | Aldesleukin | Interferon beta-1a | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Moderate | 1 | [
[
[
1648,
24,
912
]
],
[
[
1648,
25,
876
],
[
876,
63,
912
]
],
[
[
1648,
24,
851
],
[
851,
63,
912
]
],
[
[
1648,
63,
305
],
[
305,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]
],
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tizanidine"
],
[
"... | Aldesleukin may lead to a major life threatening interaction when taken with Tizanidine and Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone ... |
DB00604 | DB01072 | 1,425 | 915 | [
"DDInter385",
"DDInter129"
] | Cisapride | Atazanavir | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Major | 2 | [
[
[
1425,
25,
915
]
],
[
[
1425,
25,
1327
],
[
1327,
1,
915
]
],
[
[
1425,
6,
6017
],
[
6017,
45,
915
]
],
[
[
1425,
25,
1374
],
[
1374,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atazanavir"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavir",
"{u} (Co... | Cisapride may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Cisapride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atazanavir (Compound)
Cisapride may lead to a major life threatening interaction when taken with Abirater... |
DB09046 | DB11837 | 1,094 | 1,297 | [
"DDInter1201",
"DDInter1351"
] | Metreleptin | Osilodrostat | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1094,
24,
1297
]
],
[
[
1094,
24,
1135
],
[
1135,
23,
1297
]
],
[
[
1094,
24,
466
],
[
466,
62,
1297
]
],
[
[
1094,
24,
1320
],
[
1320... | [
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[... | Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daro... |
DB00872 | DB09074 | 1,080 | 1,362 | [
"DDInter438",
"DDInter1327"
] | Conivaptan | Olaparib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
1080,
25,
1362
]
],
[
[
1080,
63,
896
],
[
896,
24,
1362
]
],
[
[
1080,
25,
1478
],
[
1478,
24,
1362
]
],
[
[
1080,
64,
467
],
[
467,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Conivaptan may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a mode... |
DB01177 | DB08873 | 77 | 74 | [
"DDInter904",
"DDInter221"
] | Idarubicin | Boceprevir | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
77,
24,
74
]
],
[
[
77,
21,
28821
],
[
28821,
60,
74
]
],
[
[
77,
24,
1374
],
[
1374,
23,
74
]
],
[
[
77,
74,
51
],
[
51,
24,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Idarubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Sepsis"
],
[
"Sepsis",
"{u} (Side Effect) is caused by ... | Idarubicin (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Boceprevir (Compound)
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Boceprevir
Id... |
DB09039 | DB09098 | 1,670 | 98 | [
"DDInter629",
"DDInter1700"
] | Eliglustat | Somatrem | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1670,
24,
98
]
],
[
[
1670,
64,
271
],
[
271,
23,
98
]
],
[
[
1670,
63,
336
],
[
336,
24,
98
]
],
[
[
1670,
24,
159
],
[
159,
63... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",... | Eliglustat may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Somatrem
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a mo... |
DB04865 | DB08880 | 4 | 1,510 | [
"DDInter1335",
"DDInter1771"
] | Omacetaxine mepesuccinate | Teriflunomide | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
4,
25,
1510
]
],
[
[
4,
24,
221
],
[
221,
63,
1510
]
],
[
[
4,
24,
1136
],
[
1136,
24,
1510
]
],
[
[
4,
63,
1144
],
[
1144,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polioviru... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Omacetaxin... |
DB00486 | DB01176 | 1,614 | 537 | [
"DDInter1253",
"DDInter453"
] | Nabilone | Cyclizine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1614,
24,
537
]
],
[
[
1614,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1614,
24,
104
],
[
104,
1,
537
]
],
[
[
1614,
24,
601
],
[
601,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
"... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilaz... |
DB00366 | DB11186 | 1,594 | 1,609 | [
"DDInter600",
"DDInter1427"
] | Doxylamine | Pentoxyverine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1594,
24,
1609
]
],
[
[
1594,
24,
314
],
[
314,
24,
1609
]
],
[
[
1594,
63,
556
],
[
556,
24,
1609
]
],
[
[
1594,
25,
306
],
[
306,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
],
[... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and ... |
DB01030 | DB11730 | 869 | 351 | [
"DDInter1835",
"DDInter1588"
] | Topotecan | Ribociclib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
869,
24,
351
]
],
[
[
869,
24,
466
],
[
466,
62,
351
]
],
[
[
869,
24,
310
],
[
310,
24,
351
]
],
[
[
869,
63,
597
],
[
597,
24,... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabaz... |
DB00564 | DB00773 | 1,236 | 896 | [
"DDInter293",
"DDInter702"
] | Carbamazepine | Etoposide | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
1236,
24,
896
]
],
[
[
1236,
6,
5912
],
[
5912,
45,
896
]
],
[
[
1236,
18,
10375
],
[
10375,
57,
896
]
],
[
[
1236,
21,
28681
],
[
286... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound... | Carbamazepine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Etoposide (Compound)
Carbamazepine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Etoposide (Compound)
Carbamazepine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Eto... |
DB01001 | DB09080 | 688 | 144 | [
"DDInter1632",
"DDInter1331"
] | Salbutamol | Olodaterol | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
688,
24,
144
]
],
[
[
688,
23,
1247
],
[
1247,
23,
144
]
],
[
[
688,
24,
956
],
[
956,
24,
144
]
],
[
[
688,
63,
504
],
[
504,
2... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin a... |
DB09570 | DB11601 | 1,480 | 1,270 | [
"DDInter1002",
"DDInter1889"
] | Ixazomib | Tuberculin purified protein derivative | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1480,
24,
1270
]
],
[
[
1480,
63,
350
],
[
350,
24,
1270
]
],
[
[
1480,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
1480,
25,
1259
],
[
1259... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Car... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Ixazomib may lead to a major life threatening interaction when taken with Cladribine... |
DB00197 | DB01018 | 1,324 | 1,364 | [
"DDInter1881",
"DDInter847"
] | Troglitazone | Guanfacine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Moderate | 1 | [
[
[
1324,
24,
1364
]
],
[
[
1324,
24,
167
],
[
167,
24,
1364
]
],
[
[
1324,
24,
1476
],
[
1476,
63,
1364
]
],
[
[
1324,
23,
1101
],
[
1101... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanfacine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Guanfacine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Brigatini... |
DB00285 | DB06822 | 1,100 | 802 | [
"DDInter1927",
"DDInter1812"
] | Venlafaxine | Tinzaparin | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
1100,
24,
802
]
],
[
[
1100,
25,
222
],
[
222,
24,
802
]
],
[
[
1100,
1,
643
],
[
643,
24,
802
]
],
[
[
1100,
24,
1151
],
[
1151,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutra... | Venlafaxine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Venlafaxine (Compound) resembles Desvenlafaxine (Compound) and Des
Venlafaxine may cause a moderate interaction that could e... |
DB00059 | DB00649 | 1,560 | 231 | [
"DDInter1404",
"DDInter1710"
] | Pegaspargase | Stavudine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Moderate | 1 | [
[
[
1560,
24,
231
]
],
[
[
1560,
24,
139
],
[
139,
1,
231
]
],
[
[
1560,
25,
375
],
[
375,
63,
231
]
],
[
[
1560,
64,
1057
],
[
1057,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stavudine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Stavudine (Compound)
Pegaspargase may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that c... |
DB08880 | DB09078 | 1,510 | 1,228 | [
"DDInter1771",
"DDInter1036"
] | Teriflunomide | Lenvatinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1510,
25,
1228
]
],
[
[
1510,
63,
112
],
[
112,
23,
1228
]
],
[
[
1510,
64,
463
],
[
463,
23,
1228
]
],
[
[
1510,
64,
609
],
[
609,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"M... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Teriflunomide may lead to a major life threatening interaction when taken with Rifampicin and Rifampicin ... |
DB00775 | DB15233 | 1,226 | 1,650 | [
"DDInter1818",
"DDInter142"
] | Tirofiban | Avapritinib | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1226,
25,
1650
]
],
[
[
1226,
24,
557
],
[
557,
24,
1650
]
],
[
[
1226,
63,
121
],
[
121,
24,
1650
]
],
[
[
1226,
63,
1512
],
[
1512,
... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
],
[
"Deoxy... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid and Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Fenflurami... |
DB00307 | DB08903 | 1,101 | 996 | [
"DDInter202",
"DDInter170"
] | Bexarotene | Bedaquiline | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
1101,
24,
996
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1101,
21,
29282
],
[
29282,
60,
996
]
],
[
[
1101,
24,
713
],
[
713,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Bexarotene (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumara... |
DB08912 | DB12001 | 1,040 | 564 | [
"DDInter462",
"DDInter7"
] | Dabrafenib | Abemaciclib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
1040,
24,
564
]
],
[
[
1040,
63,
868
],
[
868,
24,
564
]
],
[
[
1040,
24,
982
],
[
982,
63,
564
]
],
[
[
1040,
25,
1017
],
[
1017,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivo... |
DB00218 | DB00468 | 1,176 | 1,424 | [
"DDInter1247",
"DDInter1557"
] | Moxifloxacin | Quinine | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Major | 2 | [
[
[
1176,
25,
1424
]
],
[
[
1176,
21,
29316
],
[
29316,
60,
1424
]
],
[
[
1176,
23,
112
],
[
112,
62,
1424
]
],
[
[
1176,
25,
1254
],
[
12... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Sweating"
],
[
"Sweating",
"{u} (Side Effect) is caused by {v} (Compo... | Moxifloxacin (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Quinine (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Quinin... |
DB00789 | DB01244 | 1,431 | 762 | [
"DDInter796",
"DDInter192"
] | Gadopentetic acid | Bepridil | A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1431,
24,
762
]
],
[
[
1431,
21,
29187
],
[
29187,
60,
762
]
],
[
[
1431,
21,
29187
],
[
29187,
60,
704
],
[
704,
1,
762
]
],
[
[
1431... | [
[
[
"Gadopentetic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Gadopentetic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Rhinitis"
],
[
"Rhinitis",
"{u} (Side Effec... | Gadopentetic acid (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Bepridil (Compound)
Gadopentetic acid (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Bepridil (Compound)
Gadopentetic acid (Compound)... |
DB00911 | DB08912 | 458 | 1,040 | [
"DDInter1811",
"DDInter462"
] | Tinidazole | Dabrafenib | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
458,
24,
1040
]
],
[
[
458,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
458,
7,
4634
],
[
4634,
46,
1040
]
],
[
[
458,
21,
28900
],
[
28900,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Tinidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Tinidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Tinidazole (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Dabrafenib (Compound)
Tinidazole (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compou... |
DB08889 | DB09061 | 350 | 1,627 | [
"DDInter299",
"DDInter284"
] | Carfilzomib | Cannabidiol | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
350,
24,
1627
]
],
[
[
350,
24,
384
],
[
384,
23,
1627
]
],
[
[
350,
63,
1593
],
[
1593,
23,
1627
]
],
[
[
350,
64,
888
],
[
888,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizo... |
DB00741 | DB00800 | 167 | 572 | [
"DDInter885",
"DDInter720"
] | Hydrocortisone | Fenoldopam | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Moderate | 1 | [
[
[
167,
24,
572
]
],
[
[
167,
21,
28931
],
[
28931,
60,
572
]
],
[
[
167,
1,
1220
],
[
1220,
63,
572
]
],
[
[
167,
63,
1648
],
[
1648,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenoldopam"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side Eff... | Hydrocortisone (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Fenoldopam (Compound)
Hydrocortisone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Fenoldopam
Hydrocortisone may cause a... |
DB00214 | DB00222 | 1,028 | 245 | [
"DDInter1836",
"DDInter825"
] | Torasemide | Glimepiride | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Moderate | 1 | [
[
[
1028,
24,
245
]
],
[
[
1028,
24,
959
],
[
959,
1,
245
]
],
[
[
1028,
6,
6017
],
[
6017,
45,
245
]
],
[
[
1028,
21,
28789
],
[
28789,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Glimepiride (Compound)
Torasemide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Glimepiride (Compound)
Torasemide (Compound) causes Loss of consciousness (Side Effect) a... |
DB00637 | DB11986 | 1,557 | 484 | [
"DDInter128",
"DDInter648"
] | Astemizole | Entrectinib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1557,
24,
484
]
],
[
[
1557,
23,
1247
],
[
1247,
23,
484
]
],
[
[
1557,
24,
1539
],
[
1539,
24,
484
]
],
[
[
1557,
25,
1662
],
[
1662,... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin an... |
DB00619 | DB00889 | 1,419 | 1,133 | [
"DDInter909",
"DDInter840"
] | Imatinib | Granisetron | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
1419,
24,
1133
]
],
[
[
1419,
6,
8374
],
[
8374,
45,
1133
]
],
[
[
1419,
18,
5818
],
[
5818,
57,
1133
]
],
[
[
1419,
21,
29282
],
[
29... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Granisetron (Compound)
Imatinib (Compound) downregulates ATP6V0B (Gene) and ATP6V0B (Gene) is downregulated by Granisetron (Compound)
Imatinib (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Granisetron (Compound)... |
DB00432 | DB06643 | 1,083 | 1,136 | [
"DDInter1868",
"DDInter500"
] | Trifluridine | Denosumab | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
1083,
24,
1136
]
],
[
[
1083,
25,
1377
],
[
1377,
24,
1136
]
],
[
[
1083,
25,
1510
],
[
1510,
63,
1136
]
],
[
[
1083,
24,
270
],
[
270... | [
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Trifluridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Leflun... | Trifluridine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Trifluridine may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a mo... |
DB00860 | DB01185 | 891 | 155 | [
"DDInter1513",
"DDInter759"
] | Prednisolone | Fluoxymesterone | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Moderate | 1 | [
[
[
891,
24,
155
]
],
[
[
891,
1,
11811
],
[
11811,
40,
155
]
],
[
[
891,
35,
1546
],
[
1546,
40,
155
]
],
[
[
891,
63,
1561
],
[
1561,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Potassium Canrenoate"
],
[
"Potassium Canrenoate",
... | Prednisolone (Compound) resembles Potassium Canrenoate (Compound) and Potassium Canrenoate (Compound) resembles Fluoxymesterone (Compound)
Prednisolone (Compound) resembles Methyltestosterone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone a... |
DB01044 | DB11093 | 246 | 636 | [
"DDInter809",
"DDInter273"
] | Gatifloxacin | Calcium citrate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
246,
24,
636
]
],
[
[
246,
40,
739
],
[
739,
24,
636
]
],
[
[
246,
1,
1539
],
[
1539,
24,
636
]
],
[
[
246,
24,
115
],
[
115,
25... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u} may ca... | Gatifloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Gatifloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00196 | DB00705 | 600 | 441 | [
"DDInter743",
"DDInter496"
] | Fluconazole | Delavirdine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
600,
24,
441
]
],
[
[
600,
6,
21998
],
[
21998,
45,
441
]
],
[
[
600,
21,
28709
],
[
28709,
60,
441
]
],
[
[
600,
24,
303
],
[
303,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is boun... | Fluconazole (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Delavirdine (Compound)
Fluconazole (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate dis... |
DB00285 | DB06704 | 1,100 | 247 | [
"DDInter1927",
"DDInter951"
] | Venlafaxine | Iobenguane (I-123) | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
1100,
37,
247
]
],
[
[
1100,
6,
7390
],
[
7390,
45,
247
]
],
[
[
1100,
21,
28787
],
[
28787,
60,
247
]
],
[
[
1100,
24,
820
],
[
820,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Venlafaxine",
"{u} (Compound) binds {v} (Gene)",
"SLC6... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Venlafaxine may lead to a major life threatening interaction when taken with Iobenguane
Venlafaxine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Venlafaxine (Compound) causes ... |
DB01149 | DB11837 | 851 | 1,297 | [
"DDInter1274",
"DDInter1351"
] | Nefazodone | Osilodrostat | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
851,
25,
1297
]
],
[
[
851,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
851,
23,
466
],
[
466,
62,
1297
]
],
[
[
851,
64,
222
],
[
222,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Nefazodone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Nefazodone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause ... |
DB01218 | DB09104 | 1,493 | 286 | [
"DDInter852",
"DDInter1118"
] | Halofantrine | Magnesium hydroxide | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1493,
24,
286
]
],
[
[
1493,
64,
401
],
[
401,
23,
286
]
],
[
[
1493,
63,
109
],
[
109,
23,
286
]
],
[
[
1493,
25,
859
],
[
859,
... | [
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
... | Halofantrine may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxe... |
DB08870 | DB13985 | 850 | 546 | [
"DDInter228",
"DDInter1108"
] | Brentuximab vedotin | Lutetium Lu 177 dotatate | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
850,
24,
546
]
],
[
[
850,
63,
50
],
[
50,
24,
546
]
],
[
[
850,
24,
1613
],
[
1613,
24,
546
]
],
[
[
850,
64,
1057
],
[
1057,
2... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases... |
DB00831 | DB01069 | 1,178 | 401 | [
"DDInter1866",
"DDInter1533"
] | Trifluoperazine | Promethazine | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1178,
35,
401
]
],
[
[
1178,
40,
11245
],
[
11245,
1,
401
]
],
[
[
1178,
1,
146
],
[
146,
24,
401
]
],
[
[
1178,
1,
11394
],
[
11394,
... | [
[
[
"Trifluoperazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) resembles {v} (Compound)",
"Ethopropazine"
... | Trifluoperazine (Compound) resembles Promethazine (Compound) and
Trifluoperazine (Compound) resembles Ethopropazine (Compound) and Ethopropazine (Compound) resembles Promethazine (Compound)
Trifluoperazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerba... |
DB00196 | DB01118 | 600 | 33 | [
"DDInter743",
"DDInter76"
] | Fluconazole | Amiodarone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Major | 2 | [
[
[
600,
25,
33
]
],
[
[
600,
25,
540
],
[
540,
1,
33
]
],
[
[
600,
6,
6799
],
[
6799,
45,
33
]
],
[
[
600,
54,
19230
],
[
19230,
15... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
"{... | Fluconazole may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Fluconazole (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Amiodarone (Compound)
Fluconazole (Compound) is included by Cytochrome P450 2C9 Inhibitors (Pharmac... |
DB00059 | DB00795 | 1,560 | 50 | [
"DDInter1404",
"DDInter1725"
] | Pegaspargase | Sulfasalazine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
1560,
24,
50
]
],
[
[
1560,
24,
161
],
[
161,
1,
50
]
],
[
[
1560,
24,
1144
],
[
1144,
24,
50
]
],
[
[
1560,
24,
998
],
[
998,
6... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interacti... |
DB00347 | DB00470 | 917 | 530 | [
"DDInter1871",
"DDInter601"
] | Trimethadione | Dronabinol | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
917,
24,
530
]
],
[
[
917,
24,
1614
],
[
1614,
40,
530
]
],
[
[
917,
6,
6017
],
[
6017,
45,
530
]
],
[
[
917,
21,
28708
],
[
28708,
... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Trimethadione (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dronabinol (Compound)
Trimethadione (Compound) causes Malaise (Side Effect) and Malais... |
DB00443 | DB01344 | 251 | 1,231 | [
"DDInter195",
"DDInter1830"
] | Betamethasone | Tolevamer | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
251,
24,
1231
]
],
[
[
251,
23,
1114
],
[
1114,
63,
1231
]
],
[
[
251,
24,
961
],
[
961,
63,
1231
]
],
[
[
251,
1,
1486
],
[
1486,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Licorice and L... |
DB01088 | DB08816 | 714 | 578 | [
"DDInter908",
"DDInter1802"
] | Iloprost | Ticagrelor | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
714,
24,
578
]
],
[
[
714,
24,
336
],
[
336,
23,
578
]
],
[
[
714,
63,
88
],
[
88,
23,
578
]
],
[
[
714,
23,
539
],
[
539,
62,
... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
[
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol m... |
DB00668 | DB01136 | 874 | 772 | [
"DDInter652",
"DDInter305"
] | Epinephrine | Carvedilol | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Major | 2 | [
[
[
874,
25,
772
]
],
[
[
874,
6,
5214
],
[
5214,
45,
772
]
],
[
[
874,
21,
29118
],
[
29118,
60,
772
]
],
[
[
874,
63,
542
],
[
542,
... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carvedilol"
]
],
[
[
"Epinephrine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)",
"Carve... | Epinephrine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Carvedilol (Compound)
Epinephrine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Carvedilol (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxin... |
DB00520 | DB11979 | 1,358 | 1,320 | [
"DDInter306",
"DDInter625"
] | Caspofungin | Elagolix | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1358,
24,
1320
]
],
[
[
1358,
24,
129
],
[
129,
24,
1320
]
],
[
[
1358,
63,
482
],
[
482,
24,
1320
]
],
[
[
1358,
24,
1017
],
[
1017,
... | [
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Ti... |
DB06663 | DB09078 | 1,154 | 1,228 | [
"DDInter1398",
"DDInter1036"
] | Pasireotide | Lenvatinib | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1154,
25,
1228
]
],
[
[
1154,
62,
112
],
[
112,
23,
1228
]
],
[
[
1154,
64,
1100
],
[
1100,
24,
1228
]
],
[
[
1154,
25,
938
],
[
938,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Pasireotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Pasireotide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Pasireotide may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine may ... |
DB04868 | DB11601 | 478 | 1,270 | [
"DDInter1293",
"DDInter1889"
] | Nilotinib | Tuberculin purified protein derivative | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
478,
24,
1270
]
],
[
[
478,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
478,
63,
869
],
[
869,
24,
1270
]
],
[
[
478,
64,
1064
],
[
1064,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"C... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Nilotinib may cause a moderate interaction that could exacerbate diseases when take... |
DB00163 | DB14004 | 1,461 | 398 | [
"DDInter1943",
"DDInter1806"
] | Vitamin E | Tildrakizumab | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Minor | 0 | [
[
[
1461,
23,
398
]
],
[
[
1461,
62,
58
],
[
58,
24,
398
]
],
[
[
1461,
23,
270
],
[
270,
24,
398
]
],
[
[
1461,
24,
134
],
[
134,
2... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alefacept"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Tildrakizumab
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab and Ocrelizuma... |
DB09280 | DB12141 | 1,604 | 971 | [
"DDInter1101",
"DDInter817"
] | Lumacaftor | Gilteritinib | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
1604,
25,
971
]
],
[
[
1604,
64,
1135
],
[
1135,
23,
971
]
],
[
[
1604,
25,
466
],
[
466,
62,
971
]
],
[
[
1604,
64,
1409
],
[
1409,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Lumacaftor may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Lumacaftor may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor inter... |
DB00900 | DB00945 | 45 | 1,479 | [
"DDInter544",
"DDInter20"
] | Didanosine | Acetylsalicylic acid | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
45,
24,
1479
]
],
[
[
45,
6,
10612
],
[
10612,
45,
1479
]
],
[
[
45,
21,
28803
],
[
28803,
60,
1479
]
],
[
[
45,
63,
1560
],
[
1560,
... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Didanosine",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} ... | Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Acetylsalicylic acid (Compound)
Didanosine (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Acetylsalicylic acid (Compound)
Didanosine may cause a moderate interaction that could exacerbate diseases when taken with P... |
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