drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00277 | DB00599 | 1,031 | 682 | [
"DDInter1791",
"DDInter1795"
] | Theophylline | Thiopental | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Moderate | 1 | [
[
[
1031,
24,
682
]
],
[
[
1031,
24,
1023
],
[
1023,
1,
682
]
],
[
[
1031,
6,
8374
],
[
8374,
45,
682
]
],
[
[
1031,
24,
752
],
[
752,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiopental"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Thiopental (Compound)
Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Thiopental (Compound)
Theophylline may cause a moderate interaction that could... |
DB00356 | DB04837 | 1,315 | 649 | [
"DDInter366",
"DDInter407"
] | Chlorzoxazone | Clofedanol | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1315,
24,
649
]
],
[
[
1315,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1315,
24,
832
],
[
832,
40,
649
]
],
[
[
1315,
63,
701
],
[
701,
... | [
[
[
"Chlorzoxazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Chlorzoxazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Tripe... |
DB08873 | DB12267 | 74 | 1,476 | [
"DDInter221",
"DDInter233"
] | Boceprevir | Brigatinib | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
74,
25,
1476
]
],
[
[
74,
25,
1135
],
[
1135,
23,
1476
]
],
[
[
74,
63,
168
],
[
168,
23,
1476
]
],
[
[
74,
64,
629
],
[
629,
24... | [
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Boceprevir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Boceprevir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a mi... |
DB01224 | DB01309 | 623 | 1,254 | [
"DDInter1553",
"DDInter933"
] | Quetiapine | Insulin glulisine | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
623,
24,
1254
]
],
[
[
623,
63,
274
],
[
274,
23,
1254
]
],
[
[
623,
63,
1424
],
[
1424,
24,
1254
]
],
[
[
623,
24,
1094
],
[
1094,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
],... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Quinine and ... |
DB01158 | DB06704 | 1,286 | 247 | [
"DDInter229",
"DDInter951"
] | Bretylium | Iobenguane (I-123) | Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of vol... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
1286,
37,
247
]
],
[
[
1286,
6,
7390
],
[
7390,
45,
247
]
],
[
[
1286,
21,
28921
],
[
28921,
60,
247
]
],
[
[
1286,
6,
7390
],
[
7390,... | [
[
[
"Bretylium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Bretylium",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
... | Bretylium may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Bretylium may lead to a major life threatening interaction when taken with Iobenguane
Bretylium (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Bretylium (Compound) causes Dizzines... |
DB00083 | DB01082 | 677 | 1,448 | [
"DDInter225",
"DDInter1713"
] | Botulinum toxin type A | Streptomycin | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Major | 2 | [
[
[
677,
25,
1448
]
],
[
[
677,
25,
361
],
[
361,
24,
1448
]
],
[
[
677,
25,
1481
],
[
1481,
25,
1448
]
],
[
[
677,
25,
416
],
[
416,
... | [
[
[
"Botulinum toxin type A",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Streptomycin"
]
],
[
[
"Botulinum toxin type A",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
],
[
"N... | Botulinum toxin type A may lead to a major life threatening interaction when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Botulinum toxin type A may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B m... |
DB00704 | DB14783 | 267 | 287 | [
"DDInter1263",
"DDInter574"
] | Naltrexone | Diroximel fumarate | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
267,
24,
287
]
],
[
[
267,
63,
1101
],
[
1101,
24,
287
]
],
[
[
267,
24,
384
],
[
384,
24,
287
]
],
[
[
267,
25,
1510
],
[
1510,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib an... |
DB00550 | DB00682 | 99 | 126 | [
"DDInter1541",
"DDInter1951"
] | Propylthiouracil | Warfarin | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
99,
24,
126
]
],
[
[
99,
24,
729
],
[
729,
62,
126
]
],
[
[
99,
24,
1523
],
[
1523,
23,
126
]
],
[
[
99,
63,
461
],
[
461,
23,
... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]... | Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol may cause a minor interaction that can limit clinical effects when taken with Warfarin
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and... |
DB00364 | DB01133 | 417 | 1,104 | [
"DDInter1717",
"DDInter1808"
] | Sucralfate | Tiludronic acid | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Moderate | 1 | [
[
[
417,
24,
1104
]
],
[
[
417,
23,
1512
],
[
1512,
24,
1104
]
],
[
[
417,
24,
115
],
[
115,
63,
1104
]
],
[
[
417,
23,
1512
],
[
1512,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiludronic acid"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Diclofenac"
],
[... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Tiludronic acid
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide... |
DB01069 | DB01156 | 401 | 593 | [
"DDInter1533",
"DDInter252"
] | Promethazine | Bupropion | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
401,
25,
593
]
],
[
[
401,
6,
12523
],
[
12523,
45,
593
]
],
[
[
401,
21,
28757
],
[
28757,
60,
593
]
],
[
[
401,
63,
211
],
[
211,
... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Bupr... | Promethazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bupropion (Compound)
Promethazine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and... |
DB01064 | DB01208 | 1,148 | 945 | [
"DDInter987",
"DDInter1705"
] | Isoprenaline | Sparfloxacin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
1148,
25,
945
]
],
[
[
1148,
63,
739
],
[
739,
1,
945
]
],
[
[
1148,
64,
1176
],
[
1176,
1,
945
]
],
[
[
1148,
24,
1539
],
[
1539,
... | [
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
"Lo... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Isoprenaline may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Compound)... |
DB01132 | DB15093 | 1,130 | 1,654 | [
"DDInter1472",
"DDInter1698"
] | Pioglitazone | Somapacitan | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1130,
24,
1654
]
],
[
[
1130,
63,
168
],
[
168,
23,
1654
]
],
[
[
1130,
63,
176
],
[
176,
24,
1654
]
],
[
[
1130,
24,
351
],
[
351,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine a... |
DB00502 | DB08824 | 1,300 | 591 | [
"DDInter853",
"DDInter959"
] | Haloperidol | Ioflupane I-123 | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
1300,
24,
591
]
],
[
[
1300,
21,
28734
],
[
28734,
60,
591
]
],
[
[
1300,
25,
401
],
[
401,
24,
591
]
],
[
[
1300,
63,
999
],
[
999,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Haloperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Immune system disorder"
],
[
"Immune system disorder",... | Haloperidol (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Ioflupane I-123 (Compound)
Haloperidol may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases w... |
DB00899 | DB04837 | 411 | 649 | [
"DDInter1579",
"DDInter407"
] | Remifentanil | Clofedanol | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
411,
24,
649
]
],
[
[
411,
24,
1376
],
[
1376,
24,
649
]
],
[
[
411,
63,
832
],
[
832,
40,
649
]
],
[
[
411,
63,
701
],
[
701,
2... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Tripele... |
DB09083 | DB11986 | 880 | 484 | [
"DDInter996",
"DDInter648"
] | Ivabradine | Entrectinib | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
880,
25,
484
]
],
[
[
880,
64,
774
],
[
774,
24,
484
]
],
[
[
880,
63,
1674
],
[
1674,
24,
484
]
],
[
[
880,
24,
1320
],
[
1320,
... | [
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Ivabradine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Degarelix"
],
[
"Degarelix",
"{u} ma... | Ivabradine may lead to a major life threatening interaction when taken with Degarelix and Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Ivabradine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may c... |
DB01041 | DB11642 | 770 | 938 | [
"DDInter1789",
"DDInter1480"
] | Thalidomide | Pitolisant | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
770,
24,
938
]
],
[
[
770,
63,
112
],
[
112,
23,
938
]
],
[
[
770,
63,
600
],
[
600,
24,
938
]
],
[
[
770,
24,
1228
],
[
1228,
2... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and... |
DB00281 | DB00690 | 608 | 1,216 | [
"DDInter1066",
"DDInter762"
] | Lidocaine | Flurazepam | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | A benzodiazepine derivative used mainly as a hypnotic. | Moderate | 1 | [
[
[
608,
24,
1216
]
],
[
[
608,
24,
1418
],
[
1418,
1,
1216
]
],
[
[
608,
24,
481
],
[
481,
40,
1216
]
],
[
[
608,
63,
1174
],
[
1174,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Flurazepam (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Quazepam and Quazepam (Compound) resembles Flurazepam (Compound)
Lidocain... |
DB00691 | DB11921 | 1,058 | 1,019 | [
"DDInter1237",
"DDInter492"
] | Moexipril | Deflazacort | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1058,
24,
1019
]
],
[
[
1058,
24,
959
],
[
959,
24,
1019
]
],
[
[
1058,
23,
286
],
[
286,
24,
1019
]
],
[
[
1058,
1,
664
],
[
664,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Moexipril may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide and Ma... |
DB01059 | DB11113 | 956 | 657 | [
"DDInter1313",
"DDInter307"
] | Norfloxacin | Castor oil | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
956,
24,
657
]
],
[
[
956,
24,
927
],
[
927,
63,
657
]
],
[
[
956,
24,
1491
],
[
1491,
24,
657
]
],
[
[
956,
64,
891
],
[
891,
2... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and M... |
DB00749 | DB11817 | 59 | 1,259 | [
"DDInter699",
"DDInter165"
] | Etodolac | Baricitinib | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
59,
24,
1259
]
],
[
[
59,
63,
1274
],
[
1274,
24,
1259
]
],
[
[
59,
24,
1479
],
[
1479,
24,
1259
]
],
[
[
59,
24,
384
],
[
384,
... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid... |
DB00850 | DB09082 | 1,630 | 659 | [
"DDInter1432",
"DDInter1934"
] | Perphenazine | Vilanterol | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1630,
24,
659
]
],
[
[
1630,
24,
1296
],
[
1296,
63,
659
]
],
[
[
1630,
25,
1069
],
[
1069,
24,
659
]
],
[
[
1630,
24,
1450
],
[
1450,... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Perphenazine may lead to a major life threatening interaction when taken with Vandetanib and Vande... |
DB09228 | DB09381 | 687 | 192 | [
"DDInter437",
"DDInter678"
] | Conestat alfa | Esterified estrogens | C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibi... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
687,
24,
192
]
],
[
[
687,
64,
770
],
[
770,
25,
192
]
],
[
[
687,
64,
770
],
[
770,
63,
752
],
[
752,
23,
192
]
],
[
[
687,
64,... | [
[
[
"Conestat alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Conestat alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
],
[
... | Conestat alfa may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a major life threatening interaction when taken with Esterified estrogens
Conestat alfa may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate... |
DB00559 | DB01229 | 152 | 973 | [
"DDInter223",
"DDInter1377"
] | Bosentan | Paclitaxel | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
152,
24,
973
]
],
[
[
152,
24,
310
],
[
310,
63,
973
]
],
[
[
152,
6,
8374
],
[
8374,
45,
973
]
],
[
[
152,
21,
28779
],
[
28779,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Bosentan (Compound) ... |
DB00381 | DB11837 | 376 | 1,297 | [
"DDInter79",
"DDInter1351"
] | Amlodipine | Osilodrostat | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
376,
24,
1297
]
],
[
[
376,
23,
466
],
[
466,
62,
1297
]
],
[
[
376,
23,
578
],
[
578,
24,
1297
]
],
[
[
376,
24,
401
],
[
401,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Amlodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Amlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Amlodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagr... |
DB00620 | DB09237 | 175 | 1,586 | [
"DDInter1855",
"DDInter1045"
] | Triamcinolone | Levamlodipine | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
175,
24,
1586
]
],
[
[
175,
63,
1648
],
[
1648,
24,
1586
]
],
[
[
175,
24,
549
],
[
549,
24,
1586
]
],
[
[
175,
40,
870
],
[
870,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
]... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflo... |
DB00685 | DB01362 | 1,299 | 497 | [
"DDInter1887",
"DDInter960"
] | Trovafloxacin | Iohexol | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1299,
25,
497
]
],
[
[
1299,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1299,
25,
891
],
[
891,
25,
497
]
],
[
[
1299,
1,
956
],
[
956,
... | [
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is ca... | Trovafloxacin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Trovafloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may lead to a major life threatening interaction when taken with Iohexol
Trovaflo... |
DB01045 | DB11995 | 463 | 1,634 | [
"DDInter1590",
"DDInter143"
] | Rifampicin | Avatrombopag | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Major | 2 | [
[
[
463,
25,
1634
]
],
[
[
463,
25,
760
],
[
760,
24,
1634
]
],
[
[
463,
24,
609
],
[
609,
24,
1634
]
],
[
[
463,
63,
254
],
[
254,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avatrombopag"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
],
[
"Cobicistat",
"{u}... | Rifampicin may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin ... |
DB01087 | DB11901 | 1,520 | 913 | [
"DDInter1520",
"DDInter107"
] | Primaquine | Apalutamide | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1520,
24,
913
]
],
[
[
1520,
62,
112
],
[
112,
23,
913
]
],
[
[
1520,
63,
600
],
[
600,
24,
913
]
],
[
[
1520,
24,
28
],
[
28,
2... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Primaquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fl... |
DB00685 | DB01234 | 1,299 | 1,220 | [
"DDInter1887",
"DDInter513"
] | Trovafloxacin | Dexamethasone | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Major | 2 | [
[
[
1299,
25,
1220
]
],
[
[
1299,
25,
870
],
[
870,
1,
1220
]
],
[
[
1299,
64,
175
],
[
175,
40,
1220
]
],
[
[
1299,
64,
1573
],
[
1573,
... | [
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
]
],
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
],
[
"Fludrocorti... | Trovafloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Trovafloxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Tr... |
DB01165 | DB01169 | 1,539 | 57 | [
"DDInter1325",
"DDInter120"
] | Ofloxacin | Arsenic trioxide | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1539,
25,
57
]
],
[
[
1539,
6,
5912
],
[
5912,
45,
57
]
],
[
[
1539,
62,
112
],
[
112,
23,
57
]
],
[
[
1539,
24,
603
],
[
603,
6... | [
[
[
"Ofloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Ofloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",
"Arsen... | Ofloxacin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Arsenic trioxide (Compound)
Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Ofloxaci... |
DB04948 | DB05812 | 1,084 | 1,374 | [
"DDInter1083",
"DDInter8"
] | Lofexidine | Abiraterone | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1084,
24,
1374
]
],
[
[
1084,
62,
112
],
[
112,
23,
1374
]
],
[
[
1084,
63,
1494
],
[
1494,
24,
1374
]
],
[
[
1084,
24,
594
],
[
594,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Lofexidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Lofexidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Abiraterone
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and P... |
DB00220 | DB11986 | 798 | 484 | [
"DDInter1276",
"DDInter648"
] | Nelfinavir | Entrectinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
798,
25,
484
]
],
[
[
798,
24,
466
],
[
466,
62,
484
]
],
[
[
798,
25,
1135
],
[
1135,
23,
484
]
],
[
[
798,
23,
222
],
[
222,
2... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolut... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Nelfinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause... |
DB00515 | DB01101 | 589 | 60 | [
"DDInter387",
"DDInter285"
] | Cisplatin | Capecitabine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
589,
24,
60
]
],
[
[
589,
5,
11627
],
[
11627,
44,
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[
[
589,
6,
6017
],
[
6017,
45,
60
]
],
[
[
589,
21,
28701
],
[
28701,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Cisplatin",
"{u} (Compound) treats {v} (Disease)",
"esophageal cancer"
],
[
"esophageal cancer",
"{u} (Disease)... | Cisplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Capecitabine (Compound)
Cisplatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Capecitabine (Compound)
Cisplatin (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Cape... |
DB06636 | DB09073 | 1,623 | 951 | [
"DDInter980",
"DDInter1379"
] | Isavuconazonium | Palbociclib | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1623,
24,
951
]
],
[
[
1623,
25,
1476
],
[
1476,
63,
951
]
],
[
[
1623,
24,
1033
],
[
1033,
63,
951
]
],
[
[
1623,
63,
467
],
[
467,
... | [
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
... | Isavuconazonium may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib m... |
DB00384 | DB01284 | 1,275 | 1,042 | [
"DDInter1859",
"DDInter1782"
] | Triamterene | Tetracosactide | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1275,
24,
1042
]
],
[
[
1275,
24,
123
],
[
123,
24,
1042
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],
[
[
1275,
24,
1450
],
[
1450,
63,
1042
]
],
[
[
1275,
63,
1648
],
[
1648... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and... |
DB00443 | DB11817 | 251 | 1,259 | [
"DDInter195",
"DDInter165"
] | Betamethasone | Baricitinib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
251,
25,
1259
]
],
[
[
251,
23,
1193
],
[
1193,
23,
1259
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[
[
251,
62,
1461
],
[
1461,
23,
1259
]
],
[
[
251,
24,
1274
],
[
1274,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Z... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Betamethasone may cause a minor interaction that can limit clinical effects when taken with Vitamin E an... |
DB01067 | DB01276 | 959 | 123 | [
"DDInter826",
"DDInter706"
] | Glipizide | Exenatide | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
959,
24,
123
]
],
[
[
959,
62,
1103
],
[
1103,
23,
123
]
],
[
[
959,
63,
532
],
[
532,
24,
123
]
],
[
[
959,
24,
1518
],
[
1518,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Glipizide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
"... | Glipizide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Exenatide
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine ma... |
DB00218 | DB00738 | 1,176 | 485 | [
"DDInter1247",
"DDInter1420"
] | Moxifloxacin | Pentamidine | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Major | 2 | [
[
[
1176,
25,
485
]
],
[
[
1176,
21,
29097
],
[
29097,
60,
485
]
],
[
[
1176,
23,
112
],
[
112,
62,
485
]
],
[
[
1176,
25,
971
],
[
971,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Eye pain"
],
[
"Eye pain",
"{u} (Side Effect) is caused by {v} (C... | Moxifloxacin (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Pentamidine (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pe... |
DB00023 | DB01083 | 305 | 1,142 | [
"DDInter127",
"DDInter1348"
] | Asparaginase Escherichia coli | Orlistat | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Moderate | 1 | [
[
[
305,
24,
1142
]
],
[
[
305,
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5
],
[
5,
63,
1142
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],
[
[
305,
24,
45
],
[
45,
24,
1142
]
],
[
[
305,
25,
1070
],
[
1070,
64,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Orlistat
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases... |
DB01068 | DB01619 | 1,565 | 830 | [
"DDInter411",
"DDInter1441"
] | Clonazepam | Phenindamine | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1565,
24,
830
]
],
[
[
1565,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1565,
63,
13
],
[
13,
24,
830
]
],
[
[
1565,
63,
104
],
[
104,
... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
],
[
... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound)
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction th... |
DB00289 | DB00377 | 847 | 1,494 | [
"DDInter132",
"DDInter1382"
] | Atomoxetine | Palonosetron | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Moderate | 1 | [
[
[
847,
24,
1494
]
],
[
[
847,
6,
12523
],
[
12523,
45,
1494
]
],
[
[
847,
21,
28723
],
[
28723,
60,
1494
]
],
[
[
847,
23,
112
],
[
112,... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palonosetron"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Atomoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Palonosetron (Compound)
Atomoxetine (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Palonosetron (Compound)
Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronid... |
DB00994 | DB01400 | 361 | 1,372 | [
"DDInter1277",
"DDInter1279"
] | Neomycin | Neostigmine | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. | Moderate | 1 | [
[
[
361,
24,
1372
]
],
[
[
361,
63,
751
],
[
751,
40,
1372
]
],
[
[
361,
21,
28681
],
[
28681,
60,
1372
]
],
[
[
361,
24,
1662
],
[
1662,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neostigmine"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyridostigmine"
],
[
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine (Compound) resembles Neostigmine (Compound)
Neomycin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Neostigmine (Compound)
Neomycin may cause a mod... |
DB00312 | DB01168 | 1,023 | 1,053 | [
"DDInter1423",
"DDInter1526"
] | Pentobarbital | Procarbazine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1023,
24,
1053
]
],
[
[
1023,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1023,
25,
126
],
[
126,
23,
1053
]
],
[
[
1023,
1,
1269
],
[
126... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Pentobarbital",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) i... | Pentobarbital (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Pentobarbital may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Pentobarb... |
DB00529 | DB08868 | 789 | 1,011 | [
"DDInter779",
"DDInter737"
] | Foscarnet | Fingolimod | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
789,
25,
1011
]
],
[
[
789,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
789,
23,
112
],
[
112,
23,
1011
]
],
[
[
789,
24,
144
],
[
144,
... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Effect) is caused by {... | Foscarnet (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wi... |
DB00445 | DB00656 | 322 | 827 | [
"DDInter655",
"DDInter1851"
] | Epirubicin | Trazodone | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Moderate | 1 | [
[
[
322,
24,
827
]
],
[
[
322,
24,
623
],
[
623,
40,
827
]
],
[
[
322,
24,
1630
],
[
1630,
1,
827
]
],
[
[
322,
64,
695
],
[
695,
1,... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compound... |
DB03619 | DB06441 | 557 | 936 | [
"DDInter501",
"DDInter283"
] | Deoxycholic acid | Cangrelor | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
557,
24,
936
]
],
[
[
557,
63,
477
],
[
477,
24,
936
]
],
[
[
557,
24,
1496
],
[
1496,
63,
936
]
],
[
[
557,
63,
1271
],
[
1271,
... | [
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
... | Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor
Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib... |
DB00317 | DB08873 | 883 | 74 | [
"DDInter810",
"DDInter221"
] | Gefitinib | Boceprevir | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
883,
24,
74
]
],
[
[
883,
6,
4973
],
[
4973,
45,
74
]
],
[
[
883,
21,
28882
],
[
28882,
60,
74
]
],
[
[
883,
24,
86
],
[
86,
24,... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Gefitinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Boceprevir (Compound)
Gefitinib (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Boceprevir (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when t... |
DB00254 | DB08827 | 964 | 990 | [
"DDInter598",
"DDInter1085"
] | Doxycycline | Lomitapide | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
964,
25,
990
]
],
[
[
964,
6,
8374
],
[
8374,
45,
990
]
],
[
[
964,
24,
126
],
[
126,
24,
990
]
],
[
[
964,
63,
305
],
[
305,
25... | [
[
[
"Doxycycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Doxycycline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Lomit... | Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Doxycycline may caus... |
DB04855 | DB05239 | 540 | 866 | [
"DDInter602",
"DDInter425"
] | Dronedarone | Cobimetinib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
540,
25,
866
]
],
[
[
540,
24,
214
],
[
214,
63,
866
]
],
[
[
540,
63,
1051
],
[
1051,
24,
866
]
],
[
[
540,
64,
888
],
[
888,
2... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fosta... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethim... |
DB00759 | DB00855 | 1,620 | 213 | [
"DDInter1783",
"DDInter72"
] | Tetracycline | Aminolevulinic acid | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
1620,
25,
213
]
],
[
[
1620,
23,
1577
],
[
1577,
25,
213
]
],
[
[
1620,
23,
504
],
[
504,
64,
213
]
],
[
[
1620,
1,
1572
],
[
1572,
... | [
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
],
... | Tetracycline may cause a minor interaction that can limit clinical effects when taken with Hydroflumethiazide and Hydroflumethiazide may lead to a major life threatening interaction when taken with Aminolevulinic acid
Tetracycline may cause a minor interaction that can limit clinical effects when taken with Hydrochloro... |
DB01396 | DB09268 | 1,482 | 1,662 | [
"DDInter553",
"DDInter1464"
] | Digitoxin | Picosulfuric acid | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Minor | 0 | [
[
[
1482,
23,
1662
]
],
[
[
1482,
40,
1252
],
[
1252,
23,
1662
]
],
[
[
1482,
63,
1466
],
[
1466,
24,
1662
]
],
[
[
1482,
24,
1154
],
[
11... | [
[
[
"Digitoxin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Digitoxin",
"{u} (Compound) resembles {v} (Compound)",
"Digoxin"
],
[
"Digoxin",
"{u} may cause a minor inte... | Digitoxin (Compound) resembles Digoxin (Compound) and Digoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamine and Phenylpropanolamine may cause a moderate interac... |
DB00554 | DB06605 | 1,027 | 1,409 | [
"DDInter1478",
"DDInter108"
] | Piroxicam | Apixaban | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1027,
25,
1409
]
],
[
[
1027,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
1027,
24,
1040
],
[
1040,
63,
1409
]
],
[
[
1027,
40,
1335
],
[
133... | [
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Apixaban"
... | Piroxicam (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Piroxicam (Compound) res... |
DB00331 | DB00749 | 1,645 | 59 | [
"DDInter1164",
"DDInter699"
] | Metformin | Etodolac | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
1645,
24,
59
]
],
[
[
1645,
21,
29187
],
[
29187,
60,
59
]
],
[
[
1645,
24,
1194
],
[
1194,
62,
59
]
],
[
[
1645,
24,
752
],
[
752,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Rhinitis"
],
[
"Rhinitis",
"{u} (Side Effect) is caused by ... | Metformin (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Etodolac (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Etodolac
Metfor... |
DB00526 | DB01172 | 1,555 | 416 | [
"DDInter1355",
"DDInter1004"
] | Oxaliplatin | Kanamycin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
1555,
24,
416
]
],
[
[
1555,
24,
355
],
[
355,
1,
416
]
],
[
[
1555,
63,
831
],
[
831,
24,
416
]
],
[
[
1555,
24,
712
],
[
712,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
],
[
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose (Compound) resembles Kanamycin (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin may cause a moderate interaction that co... |
DB12267 | DB15982 | 1,476 | 1,339 | [
"DDInter233",
"DDInter193"
] | Brigatinib | Berotralstat | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
1476,
24,
1339
]
],
[
[
1476,
64,
1101
],
[
1101,
23,
1339
]
],
[
[
1476,
25,
283
],
[
283,
23,
1339
]
],
[
[
1476,
63,
761
],
[
761,
... | [
[
[
"Brigatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Brigatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Brigatinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Brigatinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interac... |
DB05812 | DB12500 | 1,374 | 283 | [
"DDInter8",
"DDInter714"
] | Abiraterone | Fedratinib | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1374,
24,
283
]
],
[
[
1374,
23,
907
],
[
907,
23,
283
]
],
[
[
1374,
23,
466
],
[
466,
62,
283
]
],
[
[
1374,
25,
351
],
[
351,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Daroluta... |
DB00072 | DB01229 | 550 | 973 | [
"DDInter1846",
"DDInter1378"
] | Trastuzumab | Paclitaxel (protein-bound) | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
550,
24,
973
]
],
[
[
550,
24,
748
],
[
748,
63,
973
]
],
[
[
550,
24,
563
],
[
563,
24,
973
]
],
[
[
550,
63,
1257
],
[
1257,
2... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxe... |
DB00694 | DB00983 | 51 | 480 | [
"DDInter485",
"DDInter776"
] | Daunorubicin | Formoterol | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
51,
24,
480
]
],
[
[
51,
24,
1148
],
[
1148,
63,
480
]
],
[
[
51,
18,
5998
],
[
5998,
46,
480
]
],
[
[
51,
21,
28963
],
[
28963,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Daunorubicin (Compound) downregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Formoterol (Compound... |
DB00860 | DB08882 | 891 | 1,281 | [
"DDInter1513",
"DDInter1070"
] | Prednisolone | Linagliptin | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
891,
24,
1281
]
],
[
[
891,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
891,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
891,
21,
29081
],
[
29081,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Prednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Prednisolone (Compound) causes Angioedema (Side Effect) and ... |
DB00738 | DB01124 | 485 | 1,411 | [
"DDInter1420",
"DDInter1828"
] | Pentamidine | Tolbutamide | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
485,
24,
1411
]
],
[
[
485,
24,
959
],
[
959,
40,
1411
]
],
[
[
485,
63,
245
],
[
245,
40,
1411
]
],
[
[
485,
6,
10215
],
[
10215,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compou... |
DB09054 | DB11767 | 384 | 1,583 | [
"DDInter905",
"DDInter1643"
] | Idelalisib | Sarilumab | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
384,
24,
1583
]
],
[
[
384,
63,
267
],
[
267,
24,
1583
]
],
[
[
384,
64,
362
],
[
362,
24,
1583
]
],
[
[
384,
24,
287
],
[
287,
... | [
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[
... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Idelalisib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin may cause a m... |
DB00283 | DB01618 | 701 | 776 | [
"DDInter395",
"DDInter1239"
] | Clemastine | Molindone | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
701,
24,
776
]
],
[
[
701,
18,
6797
],
[
6797,
57,
776
]
],
[
[
701,
21,
28691
],
[
28691,
60,
776
]
],
[
[
701,
24,
100
],
[
100,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Clemastine",
"{u} (Compound) downregulates {v} (Gene)",
"CYCS"
],
[
"CYCS",
"{u} (Gene) is downregulated by {v} (... | Clemastine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Molindone (Compound)
Clemastine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Molindone (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Bromphe... |
DB00514 | DB01452 | 506 | 993 | [
"DDInter527",
"DDInter532"
] | Dextromethorphan | Diamorphine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Moderate | 1 | [
[
[
506,
24,
993
]
],
[
[
506,
1,
1044
],
[
1044,
40,
993
]
],
[
[
506,
63,
421
],
[
421,
40,
993
]
],
[
[
506,
63,
475
],
[
475,
25... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diamorphine"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) resembles {v} (Compound)",
"Codeine"
],
[
"Codeine",
"{u} (Compound) r... | Dextromethorphan (Compound) resembles Codeine (Compound) and Codeine (Compound) resembles Diamorphine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Diamorphine (Compound)
Dextromethorphan may cause a moder... |
DB08904 | DB15762 | 375 | 725 | [
"DDInter342",
"DDInter1644"
] | Certolizumab pegol | Satralizumab | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Major | 2 | [
[
[
375,
25,
725
]
],
[
[
375,
23,
1193
],
[
1193,
23,
725
]
],
[
[
375,
25,
1362
],
[
1362,
24,
725
]
],
[
[
375,
64,
372
],
[
372,
... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
... | Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Satralizumab
Certolizumab pegol may lead to a major life threatening interaction when taken with Olaparib and O... |
DB00757 | DB00976 | 1,166 | 1,056 | [
"DDInter581",
"DDInter1758"
] | Dolasetron | Telithromycin | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Major | 2 | [
[
[
1166,
25,
1056
]
],
[
[
1166,
64,
1570
],
[
1570,
40,
1056
]
],
[
[
1166,
6,
12523
],
[
12523,
45,
1056
]
],
[
[
1166,
21,
30335
],
[
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telithromycin"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
"Azithromycin",
... | Dolasetron may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Dolasetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Telithromycin (Compound)
Dolasetron (Compound) causes Bundle branch block (Side Effect) and Bund... |
DB00912 | DB00978 | 473 | 739 | [
"DDInter1581",
"DDInter1084"
] | Repaglinide | Lomefloxacin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Major | 2 | [
[
[
473,
25,
739
]
],
[
[
473,
25,
945
],
[
945,
40,
739
]
],
[
[
473,
64,
1176
],
[
1176,
1,
739
]
],
[
[
473,
64,
1467
],
[
1467,
... | [
[
[
"Repaglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Repaglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfloxacin",
... | Repaglinide may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Repaglinide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin (Compound)
Repaglinide may ... |
DB00939 | DB01249 | 1,338 | 258 | [
"DDInter1135",
"DDInter958"
] | Meclofenamic acid | Iodixanol | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
1338,
25,
258
]
],
[
[
1338,
25,
497
],
[
497,
1,
258
]
],
[
[
1338,
21,
28722
],
[
28722,
60,
258
]
],
[
[
1338,
24,
712
],
[
712,
... | [
[
[
"Meclofenamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Meclofenamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
... | Meclofenamic acid may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Meclofenamic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodixanol (Compound)
Meclofenamic acid may cause a moderate interaction that cou... |
DB01164 | DB01212 | 803 | 1,453 | [
"DDInter272",
"DDInter334"
] | Calcium chloride | Ceftriaxone | Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in ... | Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse ac... | Major | 2 | [
[
[
803,
25,
1453
]
],
[
[
803,
21,
28703
],
[
28703,
60,
1453
]
],
[
[
803,
21,
28703
],
[
28703,
60,
1024
],
[
1024,
40,
1453
]
],
[
[
8... | [
[
[
"Calcium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ceftriaxone"
]
],
[
[
"Calcium chloride",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused b... | Calcium chloride (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Ceftriaxone (Compound)
Calcium chloride (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Cefpodoxime (Compound) and Cefpodoxime (Compound) resembles Ceftriaxone (Compound)
Calcium chloride (... |
DB00710 | DB09078 | 1,199 | 1,228 | [
"DDInter897",
"DDInter1036"
] | Ibandronate | Lenvatinib | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
1199,
24,
1228
]
],
[
[
1199,
24,
770
],
[
770,
24,
1228
]
],
[
[
1199,
24,
603
],
[
603,
63,
1228
]
],
[
[
1199,
40,
963
],
[
963,
... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
],
[... | Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate... |
DB00196 | DB09039 | 600 | 1,670 | [
"DDInter743",
"DDInter629"
] | Fluconazole | Eliglustat | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
600,
25,
1670
]
],
[
[
600,
23,
479
],
[
479,
23,
1670
]
],
[
[
600,
24,
211
],
[
211,
23,
1670
]
],
[
[
600,
25,
1135
],
[
1135,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
"Donepezil",... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodi... |
DB06372 | DB10989 | 259 | 496 | [
"DDInter1594",
"DDInter858"
] | Rilonacept | Hepatitis A Vaccine | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
259,
24,
496
]
],
[
[
259,
24,
1093
],
[
1093,
63,
496
]
],
[
[
259,
63,
4
],
[
4,
24,
496
]
],
[
[
259,
24,
850
],
[
850,
24,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
],... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine ... |
DB01042 | DB01155 | 1,307 | 872 | [
"DDInter1144",
"DDInter813"
] | Melphalan | Gemifloxacin | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
1307,
23,
872
]
],
[
[
1307,
62,
739
],
[
739,
1,
872
]
],
[
[
1307,
23,
956
],
[
956,
1,
872
]
],
[
[
1307,
23,
945
],
[
945,
4... | [
[
[
"Melphalan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Melphalan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Melphalan may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Melphalan may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Gemifloxacin (Compou... |
DB00872 | DB14723 | 1,080 | 159 | [
"DDInter438",
"DDInter1026"
] | Conivaptan | Larotrectinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
1080,
25,
159
]
],
[
[
1080,
24,
222
],
[
222,
23,
159
]
],
[
[
1080,
25,
1135
],
[
1135,
23,
159
]
],
[
[
1080,
63,
63
],
[
63,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutr... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Conivaptan may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause... |
DB06016 | DB11837 | 1,508 | 1,297 | [
"DDInter300",
"DDInter1351"
] | Cariprazine | Osilodrostat | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1508,
24,
1297
]
],
[
[
1508,
63,
222
],
[
222,
23,
1297
]
],
[
[
1508,
24,
1320
],
[
1320,
63,
1297
]
],
[
[
1508,
63,
353
],
[
353,
... | [
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elag... |
DB00222 | DB00734 | 245 | 1,664 | [
"DDInter825",
"DDInter1605"
] | Glimepiride | Risperidone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
245,
24,
1664
]
],
[
[
245,
24,
924
],
[
924,
40,
1664
]
],
[
[
245,
21,
28787
],
[
28787,
60,
1664
]
],
[
[
245,
24,
1194
],
[
1194,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Glimepiride (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Risperidone (Compound)
Glimepiride may cause a moderate int... |
DB00682 | DB01112 | 126 | 665 | [
"DDInter1951",
"DDInter335"
] | Warfarin | Cefuroxime | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Moderate | 1 | [
[
[
126,
24,
665
]
],
[
[
126,
24,
1462
],
[
1462,
1,
665
]
],
[
[
126,
63,
149
],
[
149,
40,
665
]
],
[
[
126,
63,
1087
],
[
1087,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefditoren"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefuroxime (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Cefuroxime (Compound)
Wa... |
DB00982 | DB09074 | 1,517 | 1,362 | [
"DDInter991",
"DDInter1327"
] | Isotretinoin | Olaparib | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1517,
24,
1362
]
],
[
[
1517,
24,
1478
],
[
1478,
24,
1362
]
],
[
[
1517,
24,
1619
],
[
1619,
63,
1362
]
],
[
[
1517,
25,
990
],
[
990... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapar... |
DB08826 | DB11248 | 1,292 | 1,193 | [
"DDInter489",
"DDInter1965"
] | Deferiprone | Zinc gluconate | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1292,
24,
1193
]
],
[
[
1292,
64,
1096
],
[
1096,
23,
1193
]
],
[
[
1292,
25,
725
],
[
725,
62,
1193
]
],
[
[
1292,
63,
1596
],
[
1596... | [
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
],
[
... | Deferiprone may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Deferiprone may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may... |
DB06212 | DB06589 | 165 | 1,250 | [
"DDInter1833",
"DDInter1400"
] | Tolvaptan | Pazopanib | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
165,
24,
1250
]
],
[
[
165,
6,
4973
],
[
4973,
45,
1250
]
],
[
[
165,
21,
29203
],
[
29203,
60,
1250
]
],
[
[
165,
23,
1135
],
[
1135,... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Tolvaptan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Tolvaptan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pazopanib (Compound)
Tolvaptan (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Pazopanib (Compound)
Tolvaptan may cause a minor interaction that can limit clinica... |
DB00193 | DB01218 | 534 | 1,493 | [
"DDInter1841",
"DDInter852"
] | Tramadol | Halofantrine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
534,
25,
1493
]
],
[
[
534,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
534,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
534,
23,
112
],
[
112,... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Halofantr... | Tramadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Tramadol (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Tramadol may cause a minor interaction that can limit clinical effects when taken with... |
DB01075 | DB01618 | 1,376 | 776 | [
"DDInter569",
"DDInter1239"
] | Diphenhydramine | Molindone | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
1376,
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[
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1376,
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],
[
28680,
60,
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[
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1376,
74,
100
],
[
100,
24,
776
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],
[
[
1376,
63,
1442
],
[
1442,... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is cause... | Diphenhydramine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Molindone (Compound)
Diphenhydramine (Compound) resembles Brompheniramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause ... |
DB00607 | DB01229 | 1,249 | 973 | [
"DDInter1256",
"DDInter1377"
] | Nafcillin | Paclitaxel | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1249,
24,
973
]
],
[
[
1249,
24,
310
],
[
310,
63,
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[
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[
8374,
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],
[
[
1249,
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29601
],
[
29601,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Nafcillin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Nafcillin (Compoun... |
DB00006 | DB06206 | 942 | 1,268 | [
"DDInter217",
"DDInter1719"
] | Bivalirudin | Sugammadex | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Moderate | 1 | [
[
[
942,
24,
1268
]
],
[
[
942,
25,
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],
[
279,
24,
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[
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1578
],
[
1578,
24,
1268
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],
[
[
942,
25,
1409
],
[
1409,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sugammadex"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
],
[
"Anisind... | Bivalirudin may lead to a major life threatening interaction when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Sugammadex
Bivalirudin may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate in... |
DB00564 | DB12010 | 1,236 | 214 | [
"DDInter293",
"DDInter785"
] | Carbamazepine | Fostamatinib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
1236,
25,
214
]
],
[
[
1236,
25,
976
],
[
976,
24,
214
]
],
[
[
1236,
24,
723
],
[
723,
24,
214
]
],
[
[
1236,
63,
322
],
[
322,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
... | Carbamazepine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant ... |
DB00252 | DB05679 | 362 | 1,683 | [
"DDInter1460",
"DDInter1907"
] | Phenytoin | Ustekinumab | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
362,
24,
1683
]
],
[
[
362,
25,
1362
],
[
1362,
63,
1683
]
],
[
[
362,
24,
1093
],
[
1093,
63,
1683
]
],
[
[
362,
24,
281
],
[
281,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
"Olaparib",
... | Phenytoin may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a mod... |
DB00682 | DB11071 | 126 | 1,004 | [
"DDInter1951",
"DDInter1449"
] | Warfarin | Phenyl salicylate | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
126,
24,
1004
]
],
[
[
126,
63,
837
],
[
837,
23,
1004
]
],
[
[
126,
24,
101
],
[
101,
23,
1004
]
],
[
[
126,
25,
500
],
[
500,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pantoprazole"
],
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole ... |
DB00227 | DB00444 | 1,463 | 63 | [
"DDInter1098",
"DDInter1765"
] | Lovastatin | Teniposide | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Moderate | 1 | [
[
[
1463,
24,
63
]
],
[
[
1463,
6,
6017
],
[
6017,
45,
63
]
],
[
[
1463,
7,
6058
],
[
6058,
45,
63
]
],
[
[
1463,
7,
3603
],
[
3603,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
]
],
[
[
"Lovastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Lovastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Teniposide (Compound)
Lovastatin (Compound) upregulates NCOA3 (Gene) and NCOA3 (Gene) is bound by Teniposide (Compound)
Lovastatin (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Teniposide (Compound)
Lovastatin (Compound) do... |
DB00626 | DB13886 | 1,441 | 125 | [
"DDInter161",
"DDInter870"
] | Bacitracin | Human cytomegalovirus immune globulin | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human popul... | Major | 2 | [
[
[
1441,
25,
125
]
],
[
[
1441,
24,
712
],
[
712,
25,
125
]
],
[
[
1441,
40,
1481
],
[
1481,
25,
125
]
],
[
[
1441,
25,
629
],
[
629,
... | [
[
[
"Bacitracin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Human cytomegalovirus immune globulin"
]
],
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
... | Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Bacitracin (Compound) resembles Polymyxin B (Compound) and Polymyxin B may lead to a major life thre... |
DB00384 | DB09418 | 1,275 | 554 | [
"DDInter1859",
"DDInter1501"
] | Triamterene | Potassium perchlorate | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Major | 2 | [
[
[
1275,
25,
554
]
],
[
[
1275,
24,
1274
],
[
1274,
24,
554
]
],
[
[
1275,
24,
1274
],
[
1274,
24,
935
],
[
935,
24,
554
]
],
[
[
1275,
... | [
[
[
"Triamterene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Flur... |
DB00603 | DB01261 | 303 | 170 | [
"DDInter1137",
"DDInter1679"
] | Medroxyprogesterone acetate | Sitagliptin | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
303,
24,
170
]
],
[
[
303,
6,
3486
],
[
3486,
45,
170
]
],
[
[
303,
21,
28850
],
[
28850,
60,
170
]
],
[
[
303,
24,
52
],
[
52,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} ... | Medroxyprogesterone acetate (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Medroxyprogesterone acetate (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Medroxyprogesterone acetate may cause a moderate interaction that could ex... |
DB00950 | DB11901 | 1,413 | 913 | [
"DDInter732",
"DDInter107"
] | Fexofenadine | Apalutamide | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1413,
24,
913
]
],
[
[
1413,
62,
600
],
[
600,
24,
913
]
],
[
[
1413,
23,
609
],
[
609,
24,
913
]
],
[
[
1413,
24,
1320
],
[
1320,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Fexofenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fluconazole"
],
... | Fexofenadine may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Fexofenadine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and... |
DB00421 | DB08916 | 443 | 26 | [
"DDInter1707",
"DDInter32"
] | Spironolactone | Afatinib | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
443,
24,
26
]
],
[
[
443,
6,
4973
],
[
4973,
45,
26
]
],
[
[
443,
7,
9489
],
[
9489,
46,
26
]
],
[
[
443,
18,
4360
],
[
4360,
57... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Spironolactone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Spironolactone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Spironolactone (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Afatinib (Compound)
Spironolactone (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Afatinib (Compound)
Spironolacto... |
DB00189 | DB00341 | 459 | 1,242 | [
"DDInter691",
"DDInter343"
] | Ethchlorvynol | Cetirizine | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
459,
24,
1242
]
],
[
[
459,
25,
475
],
[
475,
24,
1242
]
],
[
[
459,
24,
1614
],
[
1614,
63,
1242
]
],
[
[
459,
63,
1648
],
[
1648,
... | [
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Ethchlorvynol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphi... | Ethchlorvynol may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a ... |
DB00834 | DB00927 | 932 | 1,559 | [
"DDInter1215",
"DDInter712"
] | Mifepristone | Famotidine | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
932,
24,
1559
]
],
[
[
932,
18,
10780
],
[
10780,
57,
1559
]
],
[
[
932,
21,
28729
],
[
28729,
60,
1559
]
],
[
[
932,
63,
1274
],
[
12... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Mifepristone",
"{u} (Compound) downregulates {v} (Gene)",
"CCNB2"
],
[
"CCNB2",
"{u} (Gene) is downregulated b... | Mifepristone (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Famotidine (Compound)
Mifepristone (Compound) causes Pain in extremity (Side Effect) and Pain in extremity (Side Effect) is caused by Famotidine (Compound)
Mifepristone may cause a moderate interaction that could exacerbate diseases... |
DB00405 | DB00572 | 128 | 85 | [
"DDInter517",
"DDInter136"
] | Dexbrompheniramine | Atropine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
128,
24,
85
]
],
[
[
128,
24,
19
],
[
19,
24,
85
]
],
[
[
128,
63,
357
],
[
357,
24,
85
]
],
[
[
128,
24,
551
],
[
551,
62,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Benza... |
DB00489 | DB00852 | 17 | 1,445 | [
"DDInter1704",
"DDInter1545"
] | Sotalol | Pseudoephedrine | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
17,
24,
1445
]
],
[
[
17,
24,
22
],
[
22,
40,
1445
]
],
[
[
17,
6,
1704
],
[
1704,
45,
1445
]
],
[
[
17,
21,
28763
],
[
28763,
6... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
],
[
... | Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine (Compound) resembles Pseudoephedrine (Compound)
Sotalol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Pseudoephedrine (Compound)
Sotalol (Compound) causes Chest pain (Side Effect) and Chest pain ... |
DB00564 | DB11767 | 1,236 | 1,583 | [
"DDInter293",
"DDInter1643"
] | Carbamazepine | Sarilumab | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
1236,
24,
1583
]
],
[
[
1236,
24,
267
],
[
267,
24,
1583
]
],
[
[
1236,
40,
362
],
[
362,
24,
1583
]
],
[
[
1236,
25,
1409
],
[
1409,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Carbamazepine (Compound) resembles Phenytoin (Compound) and Phenytoin may cause a moderate interaction that co... |
DB00308 | DB09472 | 347 | 1,383 | [
"DDInter901",
"DDInter1693"
] | Ibutilide | Sodium sulfate | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Major | 2 | [
[
[
347,
25,
1383
]
],
[
[
347,
25,
609
],
[
609,
24,
1383
]
],
[
[
347,
64,
521
],
[
521,
24,
1383
]
],
[
[
347,
25,
971
],
[
971,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromycin",
... | Ibutilide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Ibutilide may lead to a major life threatening interaction when taken with Goserelin and Goserelin may cause a moder... |
DB01591 | DB09104 | 667 | 286 | [
"DDInter1696",
"DDInter1118"
] | Solifenacin | Magnesium hydroxide | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
667,
24,
286
]
],
[
[
667,
63,
820
],
[
820,
23,
286
]
],
[
[
667,
63,
688
],
[
688,
24,
286
]
],
[
[
667,
25,
1593
],
[
1593,
2... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol... |
DB00087 | DB00995 | 599 | 1,112 | [
"DDInter41",
"DDInter139"
] | Alemtuzumab | Auranofin | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Moderate | 1 | [
[
[
599,
24,
1112
]
],
[
[
599,
24,
36
],
[
36,
63,
1112
]
],
[
[
599,
24,
134
],
[
134,
24,
1112
]
],
[
[
599,
63,
491
],
[
491,
24... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Auranofin"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Auranofin
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelb... |
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