drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00358 | DB00377 | 1,010 | 1,494 | [
"DDInter1140",
"DDInter1382"
] | Mefloquine | Palonosetron | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Moderate | 1 | [
[
[
1010,
24,
1494
]
],
[
[
1010,
6,
12523
],
[
12523,
45,
1494
]
],
[
[
1010,
21,
28723
],
[
28723,
60,
1494
]
],
[
[
1010,
23,
112
],
[
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palonosetron"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Palonosetron (Compound)
Mefloquine (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Palonosetron (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00081 | DB01610 | 273 | 248 | [
"DDInter1838",
"DDInter1912"
] | Tositumomab | Valganciclovir | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
273,
24,
248
]
],
[
[
273,
24,
563
],
[
563,
1,
248
]
],
[
[
273,
25,
405
],
[
405,
63,
248
]
],
[
[
273,
25,
1213
],
[
1213,
24... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Acalabrutinib and Acalabrutinib may cause a moderate interaction that could ... |
DB00549 | DB11989 | 522 | 1,434 | [
"DDInter1955",
"DDInter183"
] | Zafirlukast | Benznidazole | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
522,
24,
1434
]
],
[
[
522,
24,
788
],
[
788,
24,
1434
]
],
[
[
522,
24,
148
],
[
148,
63,
1434
]
],
[
[
522,
63,
289
],
[
289,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole a... |
DB01115 | DB09038 | 336 | 1,450 | [
"DDInter1291",
"DDInter636"
] | Nifedipine | Empagliflozin | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
336,
24,
1450
]
],
[
[
336,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
336,
24,
885
],
[
885,
24,
1450
]
],
[
[
336,
40,
84
],
[
84,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol a... |
DB00087 | DB04868 | 599 | 478 | [
"DDInter41",
"DDInter1293"
] | Alemtuzumab | Nilotinib | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
599,
24,
478
]
],
[
[
599,
24,
1468
],
[
1468,
63,
478
]
],
[
[
599,
24,
10
],
[
10,
24,
478
]
],
[
[
599,
63,
1184
],
[
1184,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone ma... |
DB00445 | DB08871 | 322 | 36 | [
"DDInter655",
"DDInter666"
] | Epirubicin | Eribulin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
322,
24,
36
]
],
[
[
322,
5,
11579
],
[
11579,
44,
36
]
],
[
[
322,
23,
1247
],
[
1247,
23,
36
]
],
[
[
322,
24,
1279
],
[
1279,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Epirubicin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treate... | Epirubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Eribulin (Compound)
Epirubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with ... |
DB00635 | DB00700 | 1,573 | 312 | [
"DDInter1515",
"DDInter656"
] | Prednisone | Eplerenone | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Moderate | 1 | [
[
[
1573,
24,
312
]
],
[
[
1573,
35,
1546
],
[
1546,
40,
312
]
],
[
[
1573,
40,
167
],
[
167,
63,
312
]
],
[
[
1573,
63,
443
],
[
443,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken w... | Prednisone (Compound) resembles Methyltestosterone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Eplerenone (Compound)
Prednisone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone m... |
DB00681 | DB01276 | 1,287 | 123 | [
"DDInter85",
"DDInter706"
] | Amphotericin B | Exenatide | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1287,
24,
123
]
],
[
[
1287,
63,
1252
],
[
1252,
23,
123
]
],
[
[
1287,
24,
708
],
[
708,
63,
123
]
],
[
[
1287,
63,
1573
],
[
1573,
... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Exenatide
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Cort... |
DB06723 | DB14006 | 115 | 972 | [
"DDInter58",
"DDInter370"
] | Aluminum hydroxide | Choline salicylate | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
115,
24,
972
]
],
[
[
115,
62,
1573
],
[
1573,
24,
972
]
],
[
[
115,
63,
1411
],
[
1411,
24,
972
]
],
[
[
115,
25,
1475
],
[
1475,
... | [
[
[
"Aluminum hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Aluminum hydroxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Predn... | Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00450 | DB11986 | 78 | 484 | [
"DDInter603",
"DDInter648"
] | Droperidol | Entrectinib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
78,
25,
484
]
],
[
[
78,
23,
112
],
[
112,
23,
484
]
],
[
[
78,
24,
222
],
[
222,
23,
484
]
],
[
[
78,
25,
774
],
[
774,
24,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Si... |
DB00471 | DB08881 | 201 | 868 | [
"DDInter1242",
"DDInter1925"
] | Montelukast | Vemurafenib | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
201,
24,
868
]
],
[
[
201,
6,
8374
],
[
8374,
45,
868
]
],
[
[
201,
7,
6952
],
[
6952,
46,
868
]
],
[
[
201,
21,
29015
],
[
29015,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Montelukast (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Vemurafenib (Compound)
Montelukast (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Vemurafenib (Co... |
DB01069 | DB08875 | 401 | 1,618 | [
"DDInter1533",
"DDInter262"
] | Promethazine | Cabozantinib | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
401,
25,
1618
]
],
[
[
401,
62,
112
],
[
112,
23,
1618
]
],
[
[
401,
24,
1032
],
[
1032,
63,
1618
]
],
[
[
401,
63,
122
],
[
122,
... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamo... |
DB01261 | DB09564 | 170 | 1,296 | [
"DDInter1679",
"DDInter930"
] | Sitagliptin | Insulin degludec | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
170,
24,
1296
]
],
[
[
170,
62,
1103
],
[
1103,
23,
1296
]
],
[
[
170,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
170,
24,
659
],
[
659,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Sitagliptin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and T... |
DB00425 | DB01259 | 558 | 392 | [
"DDInter1970",
"DDInter1024"
] | Zolpidem | Lapatinib | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
558,
24,
392
]
],
[
[
558,
6,
8374
],
[
8374,
45,
392
]
],
[
[
558,
21,
29429
],
[
29429,
60,
392
]
],
[
[
558,
24,
723
],
[
723,
... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Zolpidem",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Zolpidem (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Zolpidem (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and ... |
DB06168 | DB12332 | 1,531 | 1,619 | [
"DDInter281",
"DDInter1626"
] | Canakinumab | Rucaparib | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1531,
24,
1619
]
],
[
[
1531,
24,
259
],
[
259,
24,
1619
]
],
[
[
1531,
24,
151
],
[
151,
63,
1619
]
],
[
[
1531,
63,
84
],
[
84,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/... |
DB00526 | DB00647 | 1,555 | 675 | [
"DDInter1355",
"DDInter528"
] | Oxaliplatin | Dextropropoxyphene | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Moderate | 1 | [
[
[
1555,
24,
675
]
],
[
[
1555,
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],
[
888,
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[
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],
[
494,
1,
675
]
],
[
[
1555,
25,
1301
],
[
1301,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may lead to a major life threatening interaction when taken with Dextropropoxyphene
Oxaliplatin may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) re... |
DB00402 | DB11130 | 1,407 | 407 | [
"DDInter685",
"DDInter1344"
] | Eszopiclone | Opium | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1407,
24,
407
]
],
[
[
1407,
24,
662
],
[
662,
24,
407
]
],
[
[
1407,
63,
1594
],
[
1594,
24,
407
]
],
[
[
1407,
64,
475
],
[
475,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Dox... |
DB09080 | DB11837 | 144 | 1,297 | [
"DDInter1331",
"DDInter1351"
] | Olodaterol | Osilodrostat | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
144,
24,
1297
]
],
[
[
144,
62,
1247
],
[
1247,
23,
1297
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],
[
[
144,
63,
222
],
[
222,
23,
1297
]
],
[
[
144,
63,
623
],
[
623,
... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Olodaterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Olodaterol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine... |
DB00186 | DB00486 | 905 | 1,614 | [
"DDInter1092",
"DDInter1253"
] | Lorazepam | Nabilone | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
905,
24,
1614
]
],
[
[
905,
24,
530
],
[
530,
1,
1614
]
],
[
[
905,
21,
28769
],
[
28769,
60,
1614
]
],
[
[
905,
24,
999
],
[
999,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
... | Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Lorazepam (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Nabilone (Compound)
Lorazepam may cause a moderate inter... |
DB00069 | DB09570 | 367 | 1,480 | [
"DDInter946",
"DDInter1002"
] | Interferon alfacon-1 | Ixazomib | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
367,
24,
1480
]
],
[
[
367,
24,
440
],
[
440,
24,
1480
]
],
[
[
367,
63,
268
],
[
268,
24,
1480
]
],
[
[
367,
24,
148
],
[
148,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrasti... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim and Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Peg... |
DB01081 | DB04953 | 1,688 | 495 | [
"DDInter571",
"DDInter708"
] | Diphenoxylate | Ezogabine | A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Subst... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1688,
24,
495
]
],
[
[
1688,
63,
662
],
[
662,
24,
495
]
],
[
[
1688,
40,
543
],
[
543,
24,
495
]
],
[
[
1688,
24,
1609
],
[
1609,
... | [
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine
Diphenoxylate (Compound) resembles Loperamide (Compound) and Loperamide may cause a moderate interaction... |
DB00559 | DB11978 | 152 | 124 | [
"DDInter223",
"DDInter822"
] | Bosentan | Glasdegib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
152,
25,
124
]
],
[
[
152,
24,
1135
],
[
1135,
23,
124
]
],
[
[
152,
24,
466
],
[
466,
62,
124
]
],
[
[
152,
63,
79
],
[
79,
24,... | [
[
[
"Bosentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide ... |
DB00476 | DB00902 | 109 | 104 | [
"DDInter608",
"DDInter1168"
] | Duloxetine | Methdilazine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
109,
24,
104
]
],
[
[
109,
63,
13
],
[
13,
24,
104
]
],
[
[
109,
24,
820
],
[
820,
1,
104
]
],
[
[
109,
24,
537
],
[
537,
40,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB00819 | DB08882 | 471 | 1,281 | [
"DDInter15",
"DDInter1070"
] | Acetazolamide | Linagliptin | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
471,
24,
1281
]
],
[
[
471,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
471,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
471,
21,
29222
],
[
29222,
... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Acetazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Acetazolamide (Compound) causes Hypoglycaemia (Side Effect... |
DB00631 | DB01206 | 372 | 37 | [
"DDInter405",
"DDInter1086"
] | Clofarabine | Lomustine | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
372,
24,
37
]
],
[
[
372,
5,
11555
],
[
11555,
44,
37
]
],
[
[
372,
21,
28722
],
[
28722,
60,
37
]
],
[
[
372,
63,
1176
],
[
1176,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Clofarabine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disea... | Clofarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Clofarabine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00358 | DB11915 | 1,010 | 1,293 | [
"DDInter1140",
"DDInter1909"
] | Mefloquine | Valbenazine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1010,
24,
1293
]
],
[
[
1010,
23,
112
],
[
112,
23,
1293
]
],
[
[
1010,
63,
521
],
[
521,
24,
1293
]
],
[
[
1010,
24,
401
],
[
401,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Gose... |
DB00328 | DB00673 | 831 | 723 | [
"DDInter921",
"DDInter112"
] | Indomethacin | Aprepitant | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
831,
24,
723
]
],
[
[
831,
6,
10215
],
[
10215,
45,
723
]
],
[
[
831,
21,
28770
],
[
28770,
60,
723
]
],
[
[
831,
24,
222
],
[
222,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Indomethacin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compo... | Indomethacin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Aprepitant (Compound)
Indomethacin (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Aprepitant (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Sibutrami... |
DB00030 | DB00691 | 1,685 | 1,058 | [
"DDInter934",
"DDInter1237"
] | Insulin human | Moexipril | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Moderate | 1 | [
[
[
1685,
24,
1058
]
],
[
[
1685,
24,
1638
],
[
1638,
1,
1058
]
],
[
[
1685,
24,
954
],
[
954,
40,
1058
]
],
[
[
1685,
24,
175
],
[
175,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moexipril"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Moexipril (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Moexipril (Comp... |
DB00835 | DB00842 | 100 | 686 | [
"DDInter245",
"DDInter1359"
] | Brompheniramine | Oxazepam | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
100,
24,
686
]
],
[
[
100,
63,
695
],
[
695,
40,
686
]
],
[
[
100,
63,
1119
],
[
1119,
1,
686
]
],
[
[
100,
24,
1565
],
[
1565,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Oxaz... |
DB00159 | DB11095 | 940 | 235 | [
"DDInter903",
"DDInter505"
] | Icosapent | Desirudin | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
940,
24,
235
]
],
[
[
940,
24,
578
],
[
578,
24,
235
]
],
[
[
940,
24,
1409
],
[
1409,
25,
235
]
],
[
[
940,
63,
1271
],
[
1271,
... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban ma... |
DB00468 | DB11760 | 1,424 | 119 | [
"DDInter1557",
"DDInter1742"
] | Quinine | Talazoparib | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
1424,
24,
119
]
],
[
[
1424,
24,
441
],
[
441,
24,
119
]
],
[
[
1424,
25,
985
],
[
985,
24,
119
]
],
[
[
1424,
25,
1339
],
[
1339,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Quinine may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a... |
DB00364 | DB06777 | 417 | 780 | [
"DDInter1717",
"DDInter348"
] | Sucralfate | Chenodeoxycholic acid | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Moderate | 1 | [
[
[
417,
24,
780
]
],
[
[
417,
21,
29707
],
[
29707,
60,
780
]
],
[
[
417,
24,
279
],
[
279,
24,
780
]
],
[
[
417,
24,
1384
],
[
1384,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chenodeoxycholic acid"
]
],
[
[
"Sucralfate",
"{u} (Compound) causes {v} (Side Effect)",
"Lung disorder"
],
[
"Lung disorder",
"{u} (S... | Sucralfate (Compound) causes Lung disorder (Side Effect) and Lung disorder (Side Effect) is caused by Chenodeoxycholic acid (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases wh... |
DB01232 | DB12500 | 1,327 | 283 | [
"DDInter1640",
"DDInter714"
] | Saquinavir | Fedratinib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1327,
25,
283
]
],
[
[
1327,
24,
466
],
[
466,
62,
283
]
],
[
[
1327,
25,
351
],
[
351,
23,
283
]
],
[
[
1327,
63,
1419
],
[
1419,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daroluta... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Saquinavir may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may caus... |
DB00436 | DB00712 | 323 | 1,274 | [
"DDInter179",
"DDInter763"
] | Bendroflumethiazide | Flurbiprofen | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
323,
24,
1274
]
],
[
[
323,
21,
28709
],
[
28709,
60,
1274
]
],
[
[
323,
24,
842
],
[
842,
63,
1274
]
],
[
[
323,
40,
178
],
[
178,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Decreased appetite"
],
[
"Decreased appet... | Bendroflumethiazide (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Flurbiprofen (Compound)
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate and Methyl aminolevulinate may cause a moderate inte... |
DB01006 | DB06636 | 300 | 1,623 | [
"DDInter1040",
"DDInter980"
] | Letrozole | Isavuconazonium | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
300,
24,
1623
]
],
[
[
300,
24,
1213
],
[
1213,
24,
1623
]
],
[
[
300,
24,
214
],
[
214,
63,
1623
]
],
[
[
300,
63,
723
],
[
723,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fos... |
DB00346 | DB06788 | 472 | 1,616 | [
"DDInter44",
"DDInter864"
] | Alfuzosin | Histrelin | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
472,
24,
1616
]
],
[
[
472,
23,
112
],
[
112,
23,
1616
]
],
[
[
472,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
472,
24,
603
],
[
603,
... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Alfuzosin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidep... |
DB09118 | DB12332 | 1,580 | 1,619 | [
"DDInter1711",
"DDInter1626"
] | Stiripentol | Rucaparib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1580,
24,
1619
]
],
[
[
1580,
63,
222
],
[
222,
23,
1619
]
],
[
[
1580,
64,
1135
],
[
1135,
23,
1619
]
],
[
[
1580,
63,
309
],
[
309,
... | [
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Stiripentol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a... |
DB01009 | DB01166 | 935 | 477 | [
"DDInter1009",
"DDInter379"
] | Ketoprofen | Cilostazol | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
935,
24,
477
]
],
[
[
935,
7,
5727
],
[
5727,
46,
477
]
],
[
[
935,
18,
5901
],
[
5901,
57,
477
]
],
[
[
935,
21,
29340
],
[
29340,
... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Ketoprofen",
"{u} (Compound) upregulates {v} (Gene)",
"AGR2"
],
[
"AGR2",
"{u} (Gene) is upregulated by {v} (Com... | Ketoprofen (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Cilostazol (Compound)
Ketoprofen (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Cilostazol (Compound)
Ketoprofen (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) i... |
DB00696 | DB09065 | 826 | 760 | [
"DDInter665",
"DDInter424"
] | Ergotamine | Cobicistat | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
826,
25,
760
]
],
[
[
826,
63,
1101
],
[
1101,
23,
760
]
],
[
[
826,
24,
1374
],
[
1374,
23,
760
]
],
[
[
826,
63,
723
],
[
723,
... | [
[
[
"Ergotamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abirate... |
DB00502 | DB09065 | 1,300 | 760 | [
"DDInter853",
"DDInter424"
] | Haloperidol | Cobicistat | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1300,
24,
760
]
],
[
[
1300,
25,
1374
],
[
1374,
23,
760
]
],
[
[
1300,
24,
723
],
[
723,
24,
760
]
],
[
[
1300,
25,
868
],
[
868,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abirate... | Haloperidol may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may caus... |
DB01169 | DB11978 | 57 | 124 | [
"DDInter120",
"DDInter822"
] | Arsenic trioxide | Glasdegib | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
57,
25,
124
]
],
[
[
57,
62,
1247
],
[
1247,
23,
124
]
],
[
[
57,
25,
1079
],
[
1079,
24,
124
]
],
[
[
57,
24,
1032
],
[
1032,
6... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Arsenic trioxide may lead to a major life threatening interaction when taken with Telavancin and Te... |
DB08895 | DB09073 | 976 | 951 | [
"DDInter1825",
"DDInter1379"
] | Tofacitinib | Palbociclib | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
976,
25,
951
]
],
[
[
976,
63,
479
],
[
479,
23,
951
]
],
[
[
976,
24,
496
],
[
496,
63,
951
]
],
[
[
976,
25,
1476
],
[
1476,
6... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
"Donepezi... | Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine an... |
DB00404 | DB01110 | 523 | 86 | [
"DDInter54",
"DDInter1209"
] | Alprazolam | Miconazole | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
523,
24,
86
]
],
[
[
523,
6,
6017
],
[
6017,
45,
86
]
],
[
[
523,
18,
20102
],
[
20102,
57,
86
]
],
[
[
523,
21,
29122
],
[
29122,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Alprazolam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Alprazolam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Miconazole (Compound)
Alprazolam (Compound) downregulates FAM57A (Gene) and FAM57A (Gene) is downregulated by Miconazole (Compound)
Alprazolam (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by ... |
DB00834 | DB09075 | 932 | 498 | [
"DDInter1215",
"DDInter621"
] | Mifepristone | Edoxaban | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
932,
25,
498
]
],
[
[
932,
24,
1017
],
[
1017,
63,
498
]
],
[
[
932,
25,
1476
],
[
1476,
63,
498
]
],
[
[
932,
25,
129
],
[
129,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorlatin... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Mifepristone may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may caus... |
DB01224 | DB06699 | 623 | 774 | [
"DDInter1553",
"DDInter493"
] | Quetiapine | Degarelix | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
623,
24,
774
]
],
[
[
623,
63,
521
],
[
521,
1,
774
]
],
[
[
623,
21,
29177
],
[
29177,
60,
774
]
],
[
[
623,
62,
112
],
[
112,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Quetiapine (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Degarelix (Compound)
Quetiapine may c... |
DB00903 | DB00983 | 1,680 | 480 | [
"DDInter686",
"DDInter776"
] | Etacrynic acid | Formoterol | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1680,
24,
480
]
],
[
[
1680,
7,
5998
],
[
5998,
46,
480
]
],
[
[
1680,
21,
28963
],
[
28963,
60,
480
]
],
[
[
1680,
63,
218
],
[
218,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Etacrynic acid",
"{u} (Compound) upregulates {v} (Gene)",
"HMOX1"
],
[
"HMOX1",
"{u} (Gene) is upregulated b... | Etacrynic acid (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Formoterol (Compound)
Etacrynic acid (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Formoterol (Compound)
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with B... |
DB06448 | DB12010 | 171 | 214 | [
"DDInter1087",
"DDInter785"
] | Lonafarnib | Fostamatinib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
171,
25,
214
]
],
[
[
171,
25,
976
],
[
976,
24,
214
]
],
[
[
171,
64,
723
],
[
723,
24,
214
]
],
[
[
171,
63,
973
],
[
973,
24,... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
"{... | Lonafarnib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Lonafarnib may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate ... |
DB00008 | DB06317 | 491 | 1,626 | [
"DDInter1407",
"DDInter630"
] | Peginterferon alfa-2a | Elotuzumab | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
491,
24,
1626
]
],
[
[
491,
24,
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],
[
973,
24,
1626
]
],
[
[
491,
24,
310
],
[
310,
63,
1626
]
],
[
[
491,
25,
1477
],
[
1477,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pacli... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with... |
DB05015 | DB10343 | 1,077 | 962 | [
"DDInter174",
"DDInter160"
] | Belinostat | Bacillus calmette-guerin substrain tice live antigen | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
1077,
25,
962
]
],
[
[
1077,
64,
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],
[
1057,
25,
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]
],
[
[
1077,
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270
],
[
270,
64,
962
]
],
[
[
1077,
63,
663
],
[
663,
... | [
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Belinostat may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizum... |
DB06691 | DB11915 | 849 | 1,293 | [
"DDInter1155",
"DDInter1909"
] | Mepyramine | Valbenazine | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
849,
24,
1293
]
],
[
[
849,
63,
516
],
[
516,
24,
1293
]
],
[
[
849,
24,
1609
],
[
1609,
24,
1293
]
],
[
[
849,
74,
100
],
[
100,
... | [
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
],
... | Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverin... |
DB01211 | DB09143 | 609 | 313 | [
"DDInter393",
"DDInter1701"
] | Clarithromycin | Sonidegib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
609,
25,
313
]
],
[
[
609,
24,
101
],
[
101,
23,
313
]
],
[
[
609,
63,
1559
],
[
1559,
23,
313
]
],
[
[
609,
62,
660
],
[
660,
2... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
],
[
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole and Dexlansoprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Famoti... |
DB00816 | DB01136 | 1,674 | 772 | [
"DDInter1346",
"DDInter305"
] | Orciprenaline | Carvedilol | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Major | 2 | [
[
[
1674,
25,
772
]
],
[
[
1674,
24,
371
],
[
371,
1,
772
]
],
[
[
1674,
6,
3576
],
[
3576,
45,
772
]
],
[
[
1674,
21,
28789
],
[
28789,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carvedilol"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],
[
"Pro... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Carvedilol (Compound)
Orciprenaline (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Carvedilol (Compound)
Orciprenaline (Compound) causes Loss of consciousness (Side ... |
DB00736 | DB12615 | 660 | 1,381 | [
"DDInter676",
"DDInter1482"
] | Esomeprazole | Plazomicin | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
660,
24,
1381
]
],
[
[
660,
23,
1479
],
[
1479,
24,
1381
]
],
[
[
660,
40,
837
],
[
837,
24,
1381
]
],
[
[
660,
24,
416
],
[
416,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Esomeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
... | Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Esomeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a moder... |
DB00586 | DB09472 | 1,512 | 1,383 | [
"DDInter537",
"DDInter1693"
] | Diclofenac | Sodium sulfate | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1512,
24,
1383
]
],
[
[
1512,
63,
1252
],
[
1252,
23,
1383
]
],
[
[
1512,
24,
643
],
[
643,
24,
1383
]
],
[
[
1512,
64,
886
],
[
886,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desven... |
DB00047 | DB00850 | 176 | 1,630 | [
"DDInter932",
"DDInter1432"
] | Insulin glargine | Perphenazine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
176,
24,
1630
]
],
[
[
176,
24,
508
],
[
508,
40,
1630
]
],
[
[
176,
24,
417
],
[
417,
23,
1630
]
],
[
[
176,
24,
549
],
[
549,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Perphenazine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction t... |
DB00270 | DB06674 | 1,428 | 908 | [
"DDInter993",
"DDInter837"
] | Isradipine | Golimumab | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
1428,
24,
908
]
],
[
[
1428,
1,
336
],
[
336,
24,
908
]
],
[
[
1428,
23,
467
],
[
467,
24,
908
]
],
[
[
1428,
24,
1593
],
[
1593,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Isradipine",
"{u} (Compound) resembles {v} (Compound)",
"Nifedipine"
],
[
"Nifedipine",
"{u} may cause a moderate... | Isradipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Isradipine may cause a minor interaction that can limit clinical effects when taken with Simvastatin and Simvastatin may cause a moderate interaction that could ... |
DB00431 | DB01175 | 1,503 | 318 | [
"DDInter1072",
"DDInter672"
] | Lindane | Escitalopram | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
1503,
24,
318
]
],
[
[
1503,
63,
1230
],
[
1230,
1,
318
]
],
[
[
1503,
21,
28719
],
[
28719,
60,
318
]
],
[
[
1503,
63,
999
],
[
999,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Lindane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Escitalopram (Compound)
Lindane may cause a moderate interaction that could exac... |
DB00069 | DB08903 | 367 | 996 | [
"DDInter946",
"DDInter170"
] | Interferon alfacon-1 | Bedaquiline | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
367,
24,
996
]
],
[
[
367,
24,
112
],
[
112,
23,
996
]
],
[
[
367,
24,
713
],
[
713,
63,
996
]
],
[
[
367,
25,
593
],
[
593,
24,... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metron... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bedaquiline
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00555 | DB01246 | 706 | 820 | [
"DDInter1020",
"DDInter45"
] | Lamotrigine | Alimemazine | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
706,
24,
820
]
],
[
[
706,
24,
401
],
[
401,
24,
820
]
],
[
[
706,
24,
649
],
[
649,
1,
820
]
],
[
[
706,
7,
16703
],
[
16703,
4... | [
[
[
"Lamotrigine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Lamotrigine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and... |
DB00431 | DB00561 | 1,503 | 1,048 | [
"DDInter1072",
"DDInter591"
] | Lindane | Doxapram | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) | Moderate | 1 | [
[
[
1503,
24,
1048
]
],
[
[
1503,
24,
704
],
[
704,
1,
1048
]
],
[
[
1503,
21,
28703
],
[
28703,
60,
1048
]
],
[
[
1503,
63,
1466
],
[
146... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxapram"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
"Fenta... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Doxapram (Compound)
Lindane (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Doxapram (Compound)
Lindane may cause a moderate interaction that could exacerba... |
DB00738 | DB00867 | 485 | 1,052 | [
"DDInter1420",
"DDInter1606"
] | Pentamidine | Ritodrine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Adrenergic beta-agonist used to control premature labor. | Moderate | 1 | [
[
[
485,
24,
1052
]
],
[
[
485,
24,
1148
],
[
1148,
63,
1052
]
],
[
[
485,
63,
245
],
[
245,
24,
1052
]
],
[
[
485,
25,
1487
],
[
1487,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and ... |
DB00031 | DB11793 | 20 | 738 | [
"DDInter1764",
"DDInter1297"
] | Tenecteplase | Niraparib | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
20,
24,
738
]
],
[
[
20,
25,
1213
],
[
1213,
24,
738
]
],
[
[
20,
64,
1578
],
[
1578,
24,
738
]
],
[
[
20,
24,
848
],
[
848,
24,... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatini... | Tenecteplase may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Tenecteplase may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate inter... |
DB00580 | DB11901 | 311 | 913 | [
"DDInter1910",
"DDInter107"
] | Valdecoxib | Apalutamide | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
311,
24,
913
]
],
[
[
311,
24,
112
],
[
112,
23,
913
]
],
[
[
311,
63,
600
],
[
600,
24,
913
]
],
[
[
311,
24,
609
],
[
609,
24,... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB00197 | DB06663 | 1,324 | 1,154 | [
"DDInter1881",
"DDInter1398"
] | Troglitazone | Pasireotide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
1324,
24,
1154
]
],
[
[
1324,
63,
966
],
[
966,
40,
1154
]
],
[
[
1324,
24,
907
],
[
907,
62,
1154
]
],
[
[
1324,
24,
663
],
[
663,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Doravirine may cause a minor interaction that can... |
DB06410 | DB09481 | 1,196 | 460 | [
"DDInter595",
"DDInter1113"
] | Doxercalciferol | Magnesium carbonate | Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney d... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
1196,
24,
460
]
],
[
[
1196,
63,
1252
],
[
1252,
23,
460
]
],
[
[
1196,
64,
1098
],
[
1098,
24,
460
]
],
[
[
1196,
24,
853
],
[
853,
... | [
[
[
"Doxercalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Doxercalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"... | Doxercalciferol may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Doxercalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol and Di... |
DB00344 | DB01259 | 1,302 | 392 | [
"DDInter1543",
"DDInter1024"
] | Protriptyline | Lapatinib | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1302,
24,
392
]
],
[
[
1302,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1302,
18,
4046
],
[
4046,
45,
392
]
],
[
[
1302,
7,
17061
],
[
17061,... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Protriptyline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound... | Protriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Protriptyline (Compound) downregulates PIK3C2B (Gene) and PIK3C2B (Gene) is bound by Lapatinib (Compound)
Protriptyline (Compound) upregulates VAV3 (Gene) and VAV3 (Gene) is upregulated by Lapatinib (Compound)
Protriptyline (C... |
DB00727 | DB00907 | 685 | 290 | [
"DDInter1304",
"DDInter427"
] | Nitroglycerin | Cocaine (topical) | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
685,
24,
290
]
],
[
[
685,
62,
85
],
[
85,
1,
290
]
],
[
[
685,
21,
28741
],
[
28741,
60,
290
]
],
[
[
685,
24,
1053
],
[
1053,
... | [
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Atropine"
],
[
... | Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Atropine and Atropine (Compound) resembles Cocaine (Compound)
Nitroglycerin (Compound) causes Agitation (Side Effect) and Agit... |
DB00191 | DB00215 | 73 | 1,230 | [
"DDInter1447",
"DDInter388"
] | Phentermine | Citalopram | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Major | 2 | [
[
[
73,
25,
1230
]
],
[
[
73,
25,
318
],
[
318,
40,
1230
]
],
[
[
73,
6,
7950
],
[
7950,
45,
1230
]
],
[
[
73,
21,
28900
],
[
28900,
... | [
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
]
],
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalopram",
... | Phentermine may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram (Compound) resembles Citalopram (Compound)
Phentermine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Citalopram (Compound)
Phentermine (Compound) causes Abdominal pain (Side Effect) and Abdominal pa... |
DB01041 | DB04908 | 770 | 1,671 | [
"DDInter1789",
"DDInter741"
] | Thalidomide | Flibanserin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
770,
24,
1671
]
],
[
[
770,
63,
168
],
[
168,
23,
1671
]
],
[
[
770,
24,
830
],
[
830,
24,
1671
]
],
[
[
770,
63,
1594
],
[
1594,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Flibanserin
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phe... |
DB00861 | DB00877 | 914 | 629 | [
"DDInter551",
"DDInter1678"
] | Diflunisal | Sirolimus | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
914,
25,
629
]
],
[
[
914,
18,
8569
],
[
8569,
57,
629
]
],
[
[
914,
21,
28898
],
[
28898,
60,
629
]
],
[
[
914,
63,
167
],
[
167,
... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Diflunisal",
"{u} (Compound) downregulates {v} (Gene)",
"TYMS"
],
[
"TYMS",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Diflunisal (Compound) downregulates TYMS (Gene) and TYMS (Gene) is downregulated by Sirolimus (Compound)
Diflunisal (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Sirolimus (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Hyd... |
DB00443 | DB00808 | 251 | 1,605 | [
"DDInter195",
"DDInter916"
] | Betamethasone | Indapamide | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
251,
24,
1605
]
],
[
[
251,
24,
811
],
[
811,
1,
1605
]
],
[
[
251,
24,
1335
],
[
1335,
40,
1605
]
],
[
[
251,
6,
8374
],
[
8374,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Indapamide... |
DB00359 | DB00731 | 161 | 1,144 | [
"DDInter1721",
"DDInter1269"
] | Sulfadiazine | Nateglinide | One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
161,
24,
1144
]
],
[
[
161,
6,
6017
],
[
6017,
45,
1144
]
],
[
[
161,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
161,
1,
50
],
[
50,
... | [
[
[
"Sulfadiazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Sulfadiazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compou... | Sulfadiazine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nateglinide (Compound)
Sulfadiazine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Sulfadiazine (Compound) resembles Sulfasalazine (Compound) and Sulfasalazine may cause a moderate inte... |
DB00619 | DB01224 | 1,419 | 623 | [
"DDInter909",
"DDInter1553"
] | Imatinib | Quetiapine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1419,
24,
623
]
],
[
[
1419,
24,
827
],
[
827,
1,
623
]
],
[
[
1419,
64,
695
],
[
695,
1,
623
]
],
[
[
1419,
63,
87
],
[
87,
1,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Imatinib may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Imatinib may cause a mo... |
DB00688 | DB09322 | 955 | 1,114 | [
"DDInter1251",
"DDInter1966"
] | Mycophenolate mofetil | Zinc sulfate | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Minor | 0 | [
[
[
955,
23,
1114
]
],
[
[
955,
63,
66
],
[
66,
23,
1114
]
],
[
[
955,
64,
1057
],
[
1057,
23,
1114
]
],
[
[
955,
24,
259
],
[
259,
... | [
[
[
"Mycophenolate mofetil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Mycophenolate mofetil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efali... | Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Mycophenolate mofetil may lead to a major life threatening interaction when taken with Etanercept and... |
DB00731 | DB01250 | 1,144 | 712 | [
"DDInter1269",
"DDInter1334"
] | Nateglinide | Olsalazine | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
1144,
24,
712
]
],
[
[
1144,
24,
50
],
[
50,
40,
712
]
],
[
[
1144,
24,
914
],
[
914,
24,
712
]
],
[
[
1144,
6,
10522
],
[
10522,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction th... |
DB00844 | DB06691 | 314 | 849 | [
"DDInter1257",
"DDInter1155"
] | Nalbuphine | Mepyramine | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
314,
24,
849
]
],
[
[
314,
63,
1594
],
[
1594,
24,
849
]
],
[
[
314,
24,
272
],
[
272,
24,
849
]
],
[
[
314,
7,
2216
],
[
2216,
... | [
[
[
"Nalbuphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Nalbuphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and ... |
DB00692 | DB06691 | 274 | 849 | [
"DDInter1448",
"DDInter1155"
] | Phentolamine | Mepyramine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
274,
24,
849
]
],
[
[
274,
24,
358
],
[
358,
24,
849
]
],
[
[
274,
63,
1119
],
[
1119,
24,
849
]
],
[
[
274,
24,
407
],
[
407,
6... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepox... |
DB04844 | DB09078 | 843 | 1,228 | [
"DDInter1778",
"DDInter1036"
] | Tetrabenazine | Lenvatinib | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
843,
24,
1228
]
],
[
[
843,
62,
112
],
[
112,
23,
1228
]
],
[
[
843,
63,
609
],
[
609,
24,
1228
]
],
[
[
843,
64,
820
],
[
820,
... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Tetrabenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Tetrabenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromyci... |
DB00731 | DB00991 | 1,144 | 97 | [
"DDInter1269",
"DDInter1358"
] | Nateglinide | Oxaprozin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
1144,
24,
97
]
],
[
[
1144,
24,
939
],
[
939,
40,
97
]
],
[
[
1144,
63,
362
],
[
362,
1,
97
]
],
[
[
1144,
63,
1274
],
[
1274,
2... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Oxaprozin (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Compou... |
DB00308 | DB11057 | 347 | 720 | [
"DDInter901",
"DDInter1223"
] | Ibutilide | Mineral oil | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
347,
24,
720
]
],
[
[
347,
25,
927
],
[
927,
63,
720
]
],
[
[
347,
25,
1151
],
[
1151,
24,
720
]
],
[
[
347,
64,
600
],
[
600,
2... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafeni... | Ibutilide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Ibutilide may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate inter... |
DB00468 | DB01246 | 1,424 | 820 | [
"DDInter1557",
"DDInter45"
] | Quinine | Alimemazine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1424,
24,
820
]
],
[
[
1424,
24,
1335
],
[
1335,
24,
820
]
],
[
[
1424,
24,
675
],
[
675,
25,
820
]
],
[
[
1424,
63,
508
],
[
508,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene a... |
DB00757 | DB09098 | 1,166 | 98 | [
"DDInter581",
"DDInter1700"
] | Dolasetron | Somatrem | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1166,
24,
98
]
],
[
[
1166,
25,
1612
],
[
1612,
62,
98
]
],
[
[
1166,
25,
336
],
[
336,
24,
98
]
],
[
[
1166,
24,
159
],
[
159,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostemsavir... | Dolasetron may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Somatrem
Dolasetron may lead to a major life threatening interaction when taken with Nifedipine and Nifedipine may cause a moderate intera... |
DB01267 | DB12332 | 519 | 1,619 | [
"DDInter1381",
"DDInter1626"
] | Paliperidone | Rucaparib | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
519,
24,
1619
]
],
[
[
519,
63,
222
],
[
222,
23,
1619
]
],
[
[
519,
62,
112
],
[
112,
23,
1619
]
],
[
[
519,
24,
1662
],
[
1662,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB00531 | DB11952 | 450 | 800 | [
"DDInter456",
"DDInter612"
] | Cyclophosphamide | Duvelisib | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
450,
24,
800
]
],
[
[
450,
63,
440
],
[
440,
24,
800
]
],
[
[
450,
24,
896
],
[
896,
24,
800
]
],
[
[
450,
24,
270
],
[
270,
63,... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrastim"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim and Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Etoposide ... |
DB01015 | DB08865 | 1,247 | 1,593 | [
"DDInter1724",
"DDInter448"
] | Sulfamethoxazole | Crizotinib | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Minor | 0 | [
[
[
1247,
23,
1593
]
],
[
[
1247,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1247,
18,
10375
],
[
10375,
57,
1593
]
],
[
[
1247,
21,
29093
],
[
... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Crizotinib"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (C... | Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Sulfamethoxazole (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Crizotinib (Compound)
Sulfamethoxazole (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotin... |
DB00197 | DB00951 | 1,324 | 1,072 | [
"DDInter1881",
"DDInter986"
] | Troglitazone | Isoniazid | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1324,
24,
1072
]
],
[
[
1324,
24,
1486
],
[
1486,
62,
1072
]
],
[
[
1324,
24,
870
],
[
870,
23,
1072
]
],
[
[
1324,
24,
1130
],
[
1130... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Isoniazid
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Flud... |
DB00421 | DB01143 | 443 | 923 | [
"DDInter1707",
"DDInter65"
] | Spironolactone | Amifostine | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
443,
24,
923
]
],
[
[
443,
21,
28864
],
[
28864,
60,
923
]
],
[
[
443,
24,
714
],
[
714,
24,
923
]
],
[
[
443,
1,
312
],
[
312,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Spironolactone",
"{u} (Compound) causes {v} (Side Effect)",
"Erythema multiforme"
],
[
"Erythema multiforme",
... | Spironolactone (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Amifostine (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases... |
DB00295 | DB00555 | 475 | 706 | [
"DDInter1244",
"DDInter1020"
] | Morphine | Lamotrigine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Moderate | 1 | [
[
[
475,
24,
706
]
],
[
[
475,
24,
1275
],
[
1275,
1,
706
]
],
[
[
475,
6,
4973
],
[
4973,
45,
706
]
],
[
[
475,
21,
28800
],
[
28800,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lamotrigine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamterene"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Triamterene and Triamterene (Compound) resembles Lamotrigine (Compound)
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lamotrigine (Compound)
Morphine (Compound) causes Dyskinesia (Side Effect) and Dyskinesia (... |
DB01191 | DB01254 | 1,039 | 1,213 | [
"DDInter518",
"DDInter484"
] | Dexfenfluramine | Dasatinib | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1039,
24,
1213
]
],
[
[
1039,
6,
7950
],
[
7950,
45,
1213
]
],
[
[
1039,
18,
2551
],
[
2551,
57,
1213
]
],
[
[
1039,
62,
479
],
[
479,... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Dexfenfluramine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Co... | Dexfenfluramine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Dasatinib (Compound)
Dexfenfluramine (Compound) downregulates PFN1 (Gene) and PFN1 (Gene) is downregulated by Dasatinib (Compound)
Dexfenfluramine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Done... |
DB00795 | DB06799 | 50 | 212 | [
"DDInter1725",
"DDInter1169"
] | Sulfasalazine | Methenamine | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine). | Major | 2 | [
[
[
50,
25,
212
]
],
[
[
50,
63,
831
],
[
831,
23,
1283
],
[
1283,
24,
212
]
],
[
[
50,
63,
831
],
[
831,
23,
1384
],
[
1384,
63,
... | [
[
[
"Sulfasalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methenamine"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indomethacin"
],
[
"I... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide and Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB01185 | DB08889 | 155 | 350 | [
"DDInter759",
"DDInter299"
] | Fluoxymesterone | Carfilzomib | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Major | 2 | [
[
[
155,
25,
350
]
],
[
[
155,
21,
28762
],
[
28762,
60,
350
]
],
[
[
155,
63,
482
],
[
482,
24,
350
]
],
[
[
155,
24,
4
],
[
4,
24,... | [
[
[
"Fluoxymesterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
]
],
[
[
"Fluoxymesterone",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by ... | Fluoxymesterone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00241 | DB00366 | 288 | 1,594 | [
"DDInter257",
"DDInter600"
] | Butalbital | Doxylamine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
288,
24,
1594
]
],
[
[
288,
24,
11
],
[
11,
1,
1594
]
],
[
[
288,
24,
662
],
[
662,
63,
1594
]
],
[
[
288,
1,
536
],
[
536,
63,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene (Compound) resembles Doxylamine (Compound)
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that... |
DB00853 | DB08870 | 1,686 | 850 | [
"DDInter1762",
"DDInter228"
] | Temozolomide | Brentuximab vedotin | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1686,
24,
850
]
],
[
[
1686,
24,
496
],
[
496,
63,
850
]
],
[
[
1686,
63,
611
],
[
611,
24,
850
]
],
[
[
1686,
24,
259
],
[
259,
... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Va... | Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Temozolomide may cause a moderate interaction that could exacerbate diseases when t... |
DB00285 | DB00835 | 1,100 | 100 | [
"DDInter1927",
"DDInter245"
] | Venlafaxine | Brompheniramine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1100,
24,
100
]
],
[
[
1100,
24,
832
],
[
832,
24,
100
]
],
[
[
1100,
24,
28
],
[
28,
40,
100
]
],
[
[
1100,
24,
649
],
[
649,
6... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Bisaco... |
DB00331 | DB00363 | 1,645 | 695 | [
"DDInter1164",
"DDInter419"
] | Metformin | Clozapine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Moderate | 1 | [
[
[
1645,
24,
695
]
],
[
[
1645,
24,
1178
],
[
1178,
1,
695
]
],
[
[
1645,
24,
623
],
[
623,
40,
695
]
],
[
[
1645,
18,
5527
],
[
5527,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Clozapine (Comp... |
DB09039 | DB09073 | 1,670 | 951 | [
"DDInter629",
"DDInter1379"
] | Eliglustat | Palbociclib | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1670,
24,
951
]
],
[
[
1670,
64,
271
],
[
271,
23,
951
]
],
[
[
1670,
62,
479
],
[
479,
23,
951
]
],
[
[
1670,
24,
1476
],
[
1476,
... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mirabegron"
],
[
"Mirabegro... | Eliglustat may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Eliglustat may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a min... |
DB04868 | DB11575 | 478 | 1,676 | [
"DDInter1293",
"DDInter841"
] | Nilotinib | Grazoprevir | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Moderate | 1 | [
[
[
478,
24,
1676
]
],
[
[
478,
63,
723
],
[
723,
24,
1676
]
],
[
[
478,
25,
868
],
[
868,
24,
1676
]
],
[
[
478,
74,
1419
],
[
1419,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Grazoprevir"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Nilotinib may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause... |
DB00047 | DB01124 | 176 | 1,411 | [
"DDInter932",
"DDInter1828"
] | Insulin glargine | Tolbutamide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
176,
24,
1411
]
],
[
[
176,
24,
959
],
[
959,
40,
1411
]
],
[
[
176,
23,
721
],
[
721,
62,
1411
]
],
[
[
176,
23,
333
],
[
333,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Methylcellulose and Methylcellulose may cause a minor intera... |
DB00205 | DB06723 | 929 | 115 | [
"DDInter1550",
"DDInter58"
] | Pyrimethamine | Aluminum hydroxide | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
929,
24,
115
]
],
[
[
929,
24,
1243
],
[
1243,
24,
115
]
],
[
[
929,
25,
1292
],
[
1292,
63,
115
]
],
[
[
929,
24,
1243
],
[
1243,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Proguanil"
... | Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Proguanil and Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide
Pyrimethamine may lead to a major life threatening interaction when taken with Deferiprone and Deferipr... |
DB04899 | DB09038 | 1,549 | 1,450 | [
"DDInter1282",
"DDInter636"
] | Nesiritide | Empagliflozin | Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1549,
24,
1450
]
],
[
[
1549,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1549,
24,
1455
],
[
1455,
63,
1450
]
],
[
[
1549,
63,
1061
],
[
10... | [
[
[
"Nesiritide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Nesiritide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Nesiritide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Nesiritide may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid a... |
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