drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00831 | DB09020 | 1,178 | 28 | [
"DDInter1866",
"DDInter212"
] | Trifluoperazine | Bisacodyl | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1178,
24,
28
]
],
[
[
1178,
63,
662
],
[
662,
1,
28
]
],
[
[
1178,
63,
128
],
[
128,
40,
28
]
],
[
[
1178,
24,
100
],
[
100,
1,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) r... |
DB00197 | DB00627 | 1,324 | 265 | [
"DDInter1881",
"DDInter1286"
] | Troglitazone | Niacin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
1324,
24,
265
]
],
[
[
1324,
24,
1296
],
[
1296,
63,
265
]
],
[
[
1324,
63,
1560
],
[
1560,
24,
265
]
],
[
[
1324,
24,
663
],
[
663,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Niacin
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Pegasparg... |
DB00226 | DB01064 | 1,000 | 1,148 | [
"DDInter845",
"DDInter987"
] | Guanadrel | Isoprenaline | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1000,
24,
1148
]
],
[
[
1000,
24,
1636
],
[
1636,
24,
1148
]
],
[
[
1000,
24,
617
],
[
617,
62,
1148
]
],
[
[
1000,
24,
251
],
[
251,
... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and ... |
DB01268 | DB11986 | 1,151 | 484 | [
"DDInter1731",
"DDInter648"
] | Sunitinib | Entrectinib | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1151,
24,
484
]
],
[
[
1151,
62,
1247
],
[
1247,
23,
484
]
],
[
[
1151,
63,
1539
],
[
1539,
24,
484
]
],
[
[
1151,
24,
774
],
[
774,
... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Sunitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Sunitinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and ... |
DB00054 | DB10897 | 1,432 | 539 | [
"DDInter6",
"DDInter291"
] | Abciximab | Capsicum | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
1432,
23,
539
]
],
[
[
1432,
24,
885
],
[
885,
23,
539
]
],
[
[
1432,
25,
702
],
[
702,
23,
539
]
],
[
[
1432,
64,
582
],
[
582,
... | [
[
[
"Abciximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Abciximab may lead to a major life threatening interaction when taken with Anagrelide and Anagrelide may cause a ... |
DB00619 | DB00683 | 1,419 | 1,382 | [
"DDInter909",
"DDInter1212"
] | Imatinib | Midazolam | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Moderate | 1 | [
[
[
1419,
24,
1382
]
],
[
[
1419,
24,
1216
],
[
1216,
40,
1382
]
],
[
[
1419,
63,
902
],
[
902,
40,
1382
]
],
[
[
1419,
6,
8374
],
[
8374,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Midazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Midazolam (Compound)
Imatinib (... |
DB11363 | DB11732 | 1,276 | 1,097 | [
"DDInter39",
"DDInter1027"
] | Alectinib | Lasmiditan | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1276,
24,
1097
]
],
[
[
1276,
63,
384
],
[
384,
24,
1097
]
],
[
[
1276,
64,
1510
],
[
1510,
24,
1097
]
],
[
[
1276,
63,
1166
],
[
1166... | [
[
[
"Alectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Alectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Alectinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Alectinib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may ca... |
DB00252 | DB00902 | 362 | 104 | [
"DDInter1460",
"DDInter1168"
] | Phenytoin | Methdilazine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
362,
24,
104
]
],
[
[
362,
24,
13
],
[
13,
24,
104
]
],
[
[
362,
24,
820
],
[
820,
1,
104
]
],
[
[
362,
24,
537
],
[
537,
40,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine a... |
DB00041 | DB00366 | 1,648 | 1,594 | [
"DDInter38",
"DDInter600"
] | Aldesleukin | Doxylamine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
1648,
24,
1594
]
],
[
[
1648,
24,
1264
],
[
1264,
63,
1594
]
],
[
[
1648,
24,
888
],
[
888,
1,
1594
]
],
[
[
1648,
25,
695
],
[
695,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (... |
DB00333 | DB00792 | 576 | 832 | [
"DDInter1166",
"DDInter1878"
] | Methadone | Tripelennamine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
576,
35,
832
]
],
[
[
576,
24,
100
],
[
100,
63,
832
]
],
[
[
576,
25,
1264
],
[
1264,
63,
832
]
],
[
[
576,
1,
11364
],
[
11364,
... | [
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Methadone (Compound) resembles Tripelennamine (Compound) and
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Methadone may lead to a major life thr... |
DB01030 | DB11581 | 869 | 1,456 | [
"DDInter1835",
"DDInter1926"
] | Topotecan | Venetoclax | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
869,
24,
1456
]
],
[
[
869,
24,
259
],
[
259,
24,
1456
]
],
[
[
869,
24,
241
],
[
241,
63,
1456
]
],
[
[
869,
63,
58
],
[
58,
24... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib and Erdafit... |
DB06605 | DB15093 | 1,409 | 1,654 | [
"DDInter108",
"DDInter1698"
] | Apixaban | Somapacitan | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1409,
24,
1654
]
],
[
[
1409,
24,
351
],
[
351,
24,
1654
]
],
[
[
1409,
64,
1512
],
[
1512,
24,
1654
]
],
[
[
1409,
63,
1151
],
[
1151... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Apixaban may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may cause a m... |
DB01006 | DB01259 | 300 | 392 | [
"DDInter1040",
"DDInter1024"
] | Letrozole | Lapatinib | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
300,
24,
392
]
],
[
[
300,
5,
11579
],
[
11579,
44,
392
]
],
[
[
300,
6,
8374
],
[
8374,
45,
392
]
],
[
[
300,
21,
29429
],
[
29429,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Letrozole",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treated... | Letrozole (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Letrozole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Letrozole (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatini... |
DB00342 | DB01267 | 1,181 | 519 | [
"DDInter1770",
"DDInter1381"
] | Terfenadine | Paliperidone | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1181,
24,
519
]
],
[
[
1181,
24,
1664
],
[
1664,
1,
519
]
],
[
[
1181,
25,
924
],
[
924,
1,
519
]
],
[
[
1181,
23,
112
],
[
112,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Compound)
Terfe... |
DB00694 | DB05316 | 51 | 749 | [
"DDInter485",
"DDInter1467"
] | Daunorubicin | Pimavanserin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
51,
24,
749
]
],
[
[
51,
23,
112
],
[
112,
23,
749
]
],
[
[
51,
24,
1264
],
[
1264,
24,
749
]
],
[
[
51,
63,
521
],
[
521,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and D... |
DB00381 | DB01211 | 376 | 609 | [
"DDInter79",
"DDInter393"
] | Amlodipine | Clarithromycin | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
376,
24,
609
]
],
[
[
376,
6,
4973
],
[
4973,
45,
609
]
],
[
[
376,
18,
5432
],
[
5432,
57,
609
]
],
[
[
376,
7,
8839
],
[
8839,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Amlodipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Amlodipine (Compound) downregulates UTP14A (Gene) and UTP14A (Gene) is downregulated by Clarithromycin (Compound)
Amlodipine (Compound) upregulates GNPDA1 (Gene) and GNPDA1 (Gene) is downregulated by Clarithromycin (Compound... |
DB00302 | DB00783 | 335 | 1,438 | [
"DDInter1844",
"DDInter679"
] | Tranexamic acid | Estradiol | Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986. | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Major | 2 | [
[
[
335,
25,
1438
]
],
[
[
335,
25,
35
],
[
35,
40,
1438
]
],
[
[
335,
64,
380
],
[
380,
40,
1438
]
],
[
[
335,
21,
28661
],
[
28661,
... | [
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Estradiol"
]
],
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinestrol"
],
[
"Quinestrol",
... | Tranexamic acid may lead to a major life threatening interaction when taken with Quinestrol and Quinestrol (Compound) resembles Estradiol (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Estradiol (Compound)
Tr... |
DB00444 | DB00911 | 63 | 458 | [
"DDInter1765",
"DDInter1811"
] | Teniposide | Tinidazole | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
63,
24,
458
]
],
[
[
63,
24,
112
],
[
112,
1,
458
]
],
[
[
63,
6,
8374
],
[
8374,
45,
458
]
],
[
[
63,
7,
4634
],
[
4634,
46,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Teniposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tinidazole (Compound)
Teniposide (Compound) upregulates FOXO4 (Gene) and FOXO4 (Ge... |
DB00261 | DB09268 | 702 | 1,662 | [
"DDInter93",
"DDInter1464"
] | Anagrelide | Picosulfuric acid | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
702,
24,
1662
]
],
[
[
702,
25,
1164
],
[
1164,
24,
1662
]
],
[
[
702,
25,
484
],
[
484,
63,
1662
]
],
[
[
702,
24,
1027
],
[
1027,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
],
[
"T... | Anagrelide may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Anagrelide may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a ... |
DB00682 | DB06081 | 126 | 1,046 | [
"DDInter1951",
"DDInter286"
] | Warfarin | Caplacizumab | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Major | 2 | [
[
[
126,
25,
1046
]
],
[
[
126,
23,
1631
],
[
1631,
62,
1046
]
],
[
[
126,
24,
1039
],
[
1039,
24,
1046
]
],
[
[
126,
25,
1171
],
[
1171,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",
... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Caplacizumab
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenflura... |
DB00401 | DB09340 | 84 | 1,013 | [
"DDInter1298",
"DDInter1895"
] | Nisoldipine | Tyropanoic acid | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
84,
24,
1013
]
],
[
[
84,
1,
1081
],
[
1081,
24,
1013
]
],
[
[
84,
40,
854
],
[
854,
24,
1013
]
],
[
[
84,
24,
1431
],
[
1431,
2... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Nisoldipine",
"{u} (Compound) resembles {v} (Compound)",
"Nicardipine"
],
[
"Nicardipine",
"{u} may cause ... | Nisoldipine (Compound) resembles Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Nisoldipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Ty... |
DB01068 | DB08938 | 1,565 | 1,384 | [
"DDInter411",
"DDInter1112"
] | Clonazepam | Magaldrate | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
1565,
23,
1384
]
],
[
[
1565,
63,
752
],
[
752,
23,
1384
]
],
[
[
1565,
24,
401
],
[
401,
23,
1384
]
],
[
[
1565,
1,
686
],
[
686,
... | [
[
[
"Clonazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[
... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promet... |
DB06605 | DB11952 | 1,409 | 800 | [
"DDInter108",
"DDInter612"
] | Apixaban | Duvelisib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1409,
24,
800
]
],
[
[
1409,
63,
222
],
[
222,
23,
800
]
],
[
[
1409,
24,
1476
],
[
1476,
63,
800
]
],
[
[
1409,
63,
1683
],
[
1683,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib ... |
DB00712 | DB01244 | 1,274 | 762 | [
"DDInter763",
"DDInter192"
] | Flurbiprofen | Bepridil | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1274,
24,
762
]
],
[
[
1274,
21,
28698
],
[
28698,
60,
762
]
],
[
[
1274,
24,
1478
],
[
1478,
63,
762
]
],
[
[
1274,
25,
1527
],
[
152... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caus... | Flurbiprofen (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bepridil (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Bepridil
... |
DB00500 | DB08901 | 24 | 1,468 | [
"DDInter1831",
"DDInter1492"
] | Tolmetin | Ponatinib | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
24,
25,
1468
]
],
[
[
24,
21,
28722
],
[
28722,
60,
1468
]
],
[
[
24,
23,
1194
],
[
1194,
23,
1468
]
],
[
[
24,
24,
267
],
[
267,
... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Tolmetin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Tolmetin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ponatinib (Compound)
Tolmetin may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Ponatinib
Tolmetin may... |
DB00163 | DB00361 | 1,461 | 134 | [
"DDInter1943",
"DDInter1939"
] | Vitamin E | Vinorelbine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
1461,
24,
134
]
],
[
[
1461,
24,
147
],
[
147,
63,
134
]
],
[
[
1461,
6,
2581
],
[
2581,
46,
134
]
],
[
[
1461,
18,
10496
],
[
10496,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Vitamin E (Compound) binds PPP2CB (Gene) and PPP2CB (Gene) is upregulated by Vinorelbine (Compound)
Vitamin E ... |
DB00461 | DB08880 | 598 | 1,510 | [
"DDInter1254",
"DDInter1771"
] | Nabumetone | Teriflunomide | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
598,
25,
1510
]
],
[
[
598,
1,
43
],
[
43,
24,
1510
]
],
[
[
598,
24,
1144
],
[
1144,
24,
1510
]
],
[
[
598,
63,
1061
],
[
1061,
... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Nabumetone",
"{u} (Compound) resembles {v} (Compound)",
"Melatonin"
],
[
"Melatonin",
"{u} may cause a moderate interaction ... | Nabumetone (Compound) resembles Melatonin (Compound) and Melatonin may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that co... |
DB01082 | DB04834 | 1,448 | 276 | [
"DDInter1713",
"DDInter1571"
] | Streptomycin | Rapacuronium | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Major | 2 | [
[
[
1448,
25,
276
]
],
[
[
1448,
63,
91
],
[
91,
24,
276
]
],
[
[
1448,
64,
1441
],
[
1441,
24,
276
]
],
[
[
1448,
62,
608
],
[
608,
... | [
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rapacuronium"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vanc... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Streptomycin may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin may ... |
DB00489 | DB01611 | 17 | 1,487 | [
"DDInter1704",
"DDInter893"
] | Sotalol | Hydroxychloroquine | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
17,
25,
1487
]
],
[
[
17,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
17,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
17,
1,
88
],
[
88,
2... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
"{u}... | Sotalol may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Sotalol (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Sotalol (Compound)... |
DB00060 | DB13179 | 912 | 68 | [
"DDInter947",
"DDInter1882"
] | Interferon beta-1a | Troleandomycin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
912,
24,
68
]
],
[
[
912,
24,
1101
],
[
1101,
23,
68
]
],
[
[
912,
24,
267
],
[
267,
24,
68
]
],
[
[
912,
63,
1560
],
[
1560,
24... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarot... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Nal... |
DB00439 | DB08881 | 289 | 868 | [
"DDInter341",
"DDInter1925"
] | Cerivastatin | Vemurafenib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
289,
24,
868
]
],
[
[
289,
24,
112
],
[
112,
23,
868
]
],
[
[
289,
63,
168
],
[
168,
23,
868
]
],
[
[
289,
24,
310
],
[
310,
24,... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib a... |
DB00480 | DB11945 | 1,668 | 1,544 | [
"DDInter1035",
"DDInter144"
] | Lenalidomide | Avelumab | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year, it was also granted... | Major | 2 | [
[
[
1668,
25,
1544
]
],
[
[
1668,
1,
770
],
[
770,
25,
1544
]
],
[
[
1668,
40,
75
],
[
75,
1,
770
],
[
770,
25,
1544
]
],
[
[
1668,
... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avelumab"
]
],
[
[
"Lenalidomide",
"{u} (Compound) resembles {v} (Compound)",
"Thalidomide"
],
[
"Thalidomide",
"{u} may lead to a major life threa... | Lenalidomide (Compound) resembles Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Avelumab
Lenalidomide (Compound) resembles Pomalidomide (Compound) and Pomalidomide (Compound) resembles Thalidomide (Compound) and Thalidomide may lead to a major life threatening i... |
DB08816 | DB08864 | 578 | 786 | [
"DDInter1802",
"DDInter1595"
] | Ticagrelor | Rilpivirine | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
578,
24,
786
]
],
[
[
578,
63,
655
],
[
655,
1,
786
]
],
[
[
578,
6,
8374
],
[
8374,
45,
786
]
],
[
[
578,
21,
29343
],
[
29343,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],
[
... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Ticagrelor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Ticagrelor (Compound) causes Blood creatinine increased (Side Ef... |
DB00719 | DB00804 | 1,219 | 1,507 | [
"DDInter149",
"DDInter543"
] | Azatadine | Dicyclomine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
1219,
24,
1507
]
],
[
[
1219,
24,
551
],
[
551,
23,
1507
]
],
[
[
1219,
63,
1302
],
[
1302,
24,
1507
]
],
[
[
1219,
24,
623
],
[
623,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protri... |
DB06414 | DB06674 | 655 | 908 | [
"DDInter703",
"DDInter837"
] | Etravirine | Golimumab | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
655,
24,
908
]
],
[
[
655,
63,
268
],
[
268,
24,
908
]
],
[
[
655,
24,
1434
],
[
1434,
63,
908
]
],
[
[
655,
24,
1409
],
[
1409,
... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
]... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01394 | DB11989 | 1,554 | 1,434 | [
"DDInter431",
"DDInter183"
] | Colchicine | Benznidazole | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1554,
24,
1434
]
],
[
[
1554,
24,
375
],
[
375,
24,
1434
]
],
[
[
1554,
24,
148
],
[
148,
63,
1434
]
],
[
[
1554,
25,
1468
],
[
1468,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Sec... |
DB00352 | DB01041 | 482 | 770 | [
"DDInter1814",
"DDInter1789"
] | Tioguanine | Thalidomide | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
482,
25,
770
]
],
[
[
482,
24,
1668
],
[
1668,
1,
770
]
],
[
[
482,
5,
11555
],
[
11555,
44,
770
]
],
[
[
482,
21,
29742
],
[
29742,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
],
[
"Lenalid... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Tioguanine (Compound) cause... |
DB00398 | DB01244 | 79 | 762 | [
"DDInter1702",
"DDInter192"
] | Sorafenib | Bepridil | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
79,
25,
762
]
],
[
[
79,
24,
675
],
[
675,
40,
762
]
],
[
[
79,
6,
12523
],
[
12523,
45,
762
]
],
[
[
79,
21,
28898
],
[
28898,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],
[
"Dextro... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Bepridil (Compound)
Sorafenib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound)
Sorafenib (Compound) causes Constipation (Side Effect) a... |
DB00005 | DB06603 | 1,057 | 39 | [
"DDInter687",
"DDInter1387"
] | Etanercept | Panobinostat | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1057,
25,
39
]
],
[
[
1057,
24,
112
],
[
112,
23,
39
]
],
[
[
1057,
24,
221
],
[
221,
63,
39
]
],
[
[
1057,
24,
336
],
[
336,
24... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metro... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type... |
DB00414 | DB09278 | 590 | 852 | [
"DDInter16",
"DDInter24"
] | Acetohexamide | Activated charcoal | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
590,
24,
852
]
],
[
[
590,
63,
21
],
[
21,
24,
852
]
],
[
[
590,
24,
127
],
[
127,
24,
852
]
],
[
[
590,
24,
972
],
[
972,
63,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amitriptyline... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00372 | DB00598 | 999 | 1,523 | [
"DDInter1793",
"DDInter1013"
] | Thiethylperazine | Labetalol | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Moderate | 1 | [
[
[
999,
24,
1523
]
],
[
[
999,
24,
211
],
[
211,
1,
1523
]
],
[
[
999,
23,
1283
],
[
1283,
62,
1523
]
],
[
[
999,
62,
417
],
[
417,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Labetalol (Compound)
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide and Magnesium oxide may cause a minor inte... |
DB08880 | DB15719 | 1,510 | 487 | [
"DDInter1771",
"DDInter171"
] | Teriflunomide | Belantamab mafodotin | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Major | 2 | [
[
[
1510,
25,
487
]
],
[
[
1510,
64,
259
],
[
259,
24,
487
]
],
[
[
1510,
25,
713
],
[
713,
24,
487
]
],
[
[
1510,
63,
597
],
[
597,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacep... | Teriflunomide may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Teriflunomide may lead to a major life threatening interaction when taken with Dimethyl fumarate and Dimethyl fuma... |
DB00046 | DB00831 | 1,179 | 1,178 | [
"DDInter940",
"DDInter1866"
] | Insulin lispro | Trifluoperazine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1179,
24,
1178
]
],
[
[
1179,
24,
695
],
[
695,
40,
1178
]
],
[
[
1179,
24,
9
],
[
9,
1,
1178
]
],
[
[
1179,
24,
417
],
[
417,
2... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembl... |
DB01024 | DB06636 | 1,096 | 1,623 | [
"DDInter1252",
"DDInter980"
] | Mycophenolic acid | Isavuconazonium | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1096,
24,
1623
]
],
[
[
1096,
25,
976
],
[
976,
63,
1623
]
],
[
[
1096,
63,
629
],
[
629,
24,
1623
]
],
[
[
1096,
64,
303
],
[
303,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
... | Mycophenolic acid may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and S... |
DB01174 | DB01233 | 697 | 1,311 | [
"DDInter1442",
"DDInter1197"
] | Phenobarbital | Metoclopramide | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
697,
24,
1311
]
],
[
[
697,
25,
1151
],
[
1151,
40,
1311
]
],
[
[
697,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
697,
63,
1010
],
[
1010... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
],
[
"S... | Phenobarbital may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Phenobarbital (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Phenobarbital may cause a moderate interactio... |
DB00163 | DB05679 | 1,461 | 1,683 | [
"DDInter1943",
"DDInter1907"
] | Vitamin E | Ustekinumab | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Minor | 0 | [
[
[
1461,
23,
1683
]
],
[
[
1461,
62,
967
],
[
967,
63,
1683
]
],
[
[
1461,
23,
1093
],
[
1093,
63,
1683
]
],
[
[
1461,
23,
881
],
[
881,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ustekinumab"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Antilymphocyte immunoglobulin (h... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Antilymphocyte immunoglobulin (horse) and Antilymphocyte immunoglobulin (horse) may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Vitamin E may cause a minor interaction that can limit clini... |
DB00928 | DB10343 | 1,426 | 962 | [
"DDInter148",
"DDInter160"
] | Azacitidine | Bacillus calmette-guerin substrain tice live antigen | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
1426,
25,
962
]
],
[
[
1426,
64,
1057
],
[
1057,
25,
962
]
],
[
[
1426,
24,
270
],
[
270,
64,
962
]
],
[
[
1426,
1,
1488
],
[
1488,
... | [
[
[
"Azacitidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Azacitidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Azacitidine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Ocreliz... |
DB00598 | DB00704 | 1,523 | 267 | [
"DDInter1013",
"DDInter1263"
] | Labetalol | Naltrexone | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1523,
24,
267
]
],
[
[
1523,
63,
475
],
[
475,
25,
267
]
],
[
[
1523,
21,
28695
],
[
28695,
60,
267
]
],
[
[
1523,
24,
850
],
[
850,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Naltrexone
Labetalol (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Naltrexone (Compound)
Labetalol may cause... |
DB00242 | DB11003 | 1,064 | 748 | [
"DDInter392",
"DDInter100"
] | Cladribine | Anthrax vaccine | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1064,
24,
748
]
],
[
[
1064,
25,
322
],
[
322,
24,
748
]
],
[
[
1064,
64,
168
],
[
168,
24,
748
]
],
[
[
1064,
25,
564
],
[
564,
... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
],
[
"Epiru... | Cladribine may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Cladribine may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a moderate... |
DB00059 | DB14444 | 1,560 | 151 | [
"DDInter1404",
"DDInter924"
] | Pegaspargase | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1560,
24,
151
]
],
[
[
1560,
24,
482
],
[
482,
24,
151
]
],
[
[
1560,
25,
375
],
[
375,
24,
151
]
],
[
[
1560,
64,
1057
],
[
1057,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that cou... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Pegaspargase may lead to a major li... |
DB00427 | DB01409 | 1,233 | 1,415 | [
"DDInter1879",
"DDInter1815"
] | Triprolidine | Tiotropium | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1233,
24,
1415
]
],
[
[
1233,
6,
12523
],
[
12523,
45,
1415
]
],
[
[
1233,
24,
146
],
[
146,
24,
1415
]
],
[
[
1233,
63,
1594
],
[
159... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Triprolidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Triprolidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tiotropium (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Tiotropium
Triprolidi... |
DB00607 | DB11828 | 1,249 | 1,406 | [
"DDInter1256",
"DDInter1281"
] | Nafcillin | Neratinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
1249,
25,
1406
]
],
[
[
1249,
24,
1135
],
[
1135,
23,
1406
]
],
[
[
1249,
24,
392
],
[
392,
24,
1406
]
],
[
[
1249,
63,
1195
],
[
1195... | [
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may ... |
DB01080 | DB04837 | 855 | 649 | [
"DDInter1933",
"DDInter407"
] | Vigabatrin | Clofedanol | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
855,
24,
649
]
],
[
[
855,
63,
1376
],
[
1376,
24,
649
]
],
[
[
855,
63,
832
],
[
832,
40,
649
]
],
[
[
855,
64,
888
],
[
888,
4... | [
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB08871 | DB11718 | 36 | 927 | [
"DDInter666",
"DDInter640"
] | Eribulin | Encorafenib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
36,
24,
927
]
],
[
[
36,
63,
112
],
[
112,
23,
927
]
],
[
[
36,
62,
1247
],
[
1247,
23,
927
]
],
[
[
36,
24,
720
],
[
720,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Eribulin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and S... |
DB00353 | DB09330 | 588 | 985 | [
"DDInter1187",
"DDInter1352"
] | Methylergometrine | Osimertinib | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
588,
24,
985
]
],
[
[
588,
24,
1478
],
[
1478,
24,
985
]
],
[
[
588,
24,
283
],
[
283,
63,
985
]
],
[
[
588,
63,
1101
],
[
1101,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Fedratin... |
DB00970 | DB08908 | 0 | 713 | [
"DDInter466",
"DDInter564"
] | Dactinomycin | Dimethyl fumarate | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
0,
24,
713
]
],
[
[
0,
24,
4
],
[
4,
24,
713
]
],
[
[
0,
24,
270
],
[
270,
63,
713
]
],
[
[
0,
63,
134
],
[
134,
24,
713
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepe... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Dactinomycin may cause a moderate interaction that could exacerbate disea... |
DB00030 | DB09043 | 1,685 | 135 | [
"DDInter934",
"DDInter36"
] | Insulin human | Albiglutide | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1685,
24,
135
]
],
[
[
1685,
23,
1103
],
[
1103,
23,
135
]
],
[
[
1685,
24,
624
],
[
624,
24,
135
]
],
[
[
1685,
24,
320
],
[
320,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Insulin human",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin human may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotri... |
DB00792 | DB01224 | 832 | 623 | [
"DDInter1878",
"DDInter1553"
] | Tripelennamine | Quetiapine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
832,
24,
623
]
],
[
[
832,
63,
827
],
[
827,
1,
623
]
],
[
[
832,
24,
851
],
[
851,
1,
623
]
],
[
[
832,
40,
508
],
[
508,
1,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Quetiapine (Comp... |
DB00668 | DB04861 | 874 | 1,592 | [
"DDInter652",
"DDInter1271"
] | Epinephrine | Nebivolol | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
874,
24,
1592
]
],
[
[
874,
6,
3576
],
[
3576,
45,
1592
]
],
[
[
874,
21,
28691
],
[
28691,
60,
1592
]
],
[
[
874,
24,
1450
],
[
1450,... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Epinephrine",
"{u} (Compound) binds {v} (Gene)",
"ADRB2"
],
[
"ADRB2",
"{u} (Gene) is bound by {v} (Compound)",
... | Epinephrine (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Nebivolol (Compound)
Epinephrine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nebivolol (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and ... |
DB00477 | DB00694 | 216 | 51 | [
"DDInter363",
"DDInter485"
] | Chlorpromazine | Daunorubicin | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
216,
24,
51
]
],
[
[
216,
6,
7950
],
[
7950,
45,
51
]
],
[
[
216,
7,
6448
],
[
6448,
46,
51
]
],
[
[
216,
18,
1918
],
[
1918,
57... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (C... | Chlorpromazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Daunorubicin (Compound)
Chlorpromazine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is upregulated by Daunorubicin (Compound)
Chlorpromazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Daunorubicin (Compound)
... |
DB00470 | DB01203 | 530 | 699 | [
"DDInter601",
"DDInter1255"
] | Dronabinol | Nadolol | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
530,
24,
699
]
],
[
[
530,
24,
729
],
[
729,
1,
699
]
],
[
[
530,
6,
4973
],
[
4973,
45,
699
]
],
[
[
530,
21,
29316
],
[
29316,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Dronabinol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nadolol (Compound)
Dronabinol (Compound) causes Sweating (Side Effect) and Sweating (Side Eff... |
DB01240 | DB11793 | 885 | 738 | [
"DDInter657",
"DDInter1297"
] | Epoprostenol | Niraparib | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
885,
24,
738
]
],
[
[
885,
25,
1213
],
[
1213,
24,
738
]
],
[
[
885,
63,
1578
],
[
1578,
24,
738
]
],
[
[
885,
64,
202
],
[
202,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Epoprostenol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatini... | Epoprostenol may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin may cause a... |
DB00601 | DB00902 | 453 | 104 | [
"DDInter1073",
"DDInter1168"
] | Linezolid | Methdilazine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
453,
24,
104
]
],
[
[
453,
63,
13
],
[
13,
24,
104
]
],
[
[
453,
24,
820
],
[
820,
1,
104
]
],
[
[
453,
24,
537
],
[
537,
40,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine a... |
DB01170 | DB01309 | 1,150 | 1,254 | [
"DDInter846",
"DDInter933"
] | Guanethidine | Insulin glulisine | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1150,
24,
1254
]
],
[
[
1150,
63,
167
],
[
167,
24,
1254
]
],
[
[
1150,
24,
1220
],
[
1220,
24,
1254
]
],
[
[
1150,
24,
1450
],
[
1450... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with De... |
DB00307 | DB11730 | 1,101 | 351 | [
"DDInter202",
"DDInter1588"
] | Bexarotene | Ribociclib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1101,
24,
351
]
],
[
[
1101,
23,
271
],
[
271,
23,
351
]
],
[
[
1101,
24,
466
],
[
466,
62,
351
]
],
[
[
1101,
24,
1627
],
[
1627,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daroluta... |
DB00705 | DB12941 | 441 | 466 | [
"DDInter496",
"DDInter481"
] | Delavirdine | Darolutamide | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
441,
23,
466
]
],
[
[
441,
23,
1374
],
[
1374,
23,
466
]
],
[
[
441,
63,
600
],
[
600,
23,
466
]
],
[
[
441,
25,
351
],
[
351,
2... | [
[
[
"Delavirdine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Delavirdine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Abiraterone"
],
[
... | Delavirdine may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB01118 | DB09082 | 33 | 659 | [
"DDInter76",
"DDInter1934"
] | Amiodarone | Vilanterol | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
33,
24,
659
]
],
[
[
33,
25,
1220
],
[
1220,
23,
659
]
],
[
[
33,
64,
870
],
[
870,
23,
659
]
],
[
[
33,
24,
617
],
[
617,
23,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamet... | Amiodarone may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Amiodarone may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone may cause a... |
DB12267 | DB15091 | 1,476 | 676 | [
"DDInter233",
"DDInter1901"
] | Brigatinib | Upadacitinib | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1476,
25,
676
]
],
[
[
1476,
63,
1430
],
[
1430,
24,
676
]
],
[
[
1476,
64,
1249
],
[
1249,
24,
676
]
],
[
[
1476,
25,
283
],
[
283,
... | [
[
[
"Brigatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Brigatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Brigatinib may lead to a major life threatening interaction when taken with Nafcillin and Nafcillin may ca... |
DB00106 | DB00398 | 618 | 79 | [
"DDInter4",
"DDInter1702"
] | Abarelix | Sorafenib | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
618,
24,
79
]
],
[
[
618,
23,
1247
],
[
1247,
62,
79
]
],
[
[
618,
24,
1164
],
[
1164,
63,
79
]
],
[
[
618,
24,
1100
],
[
1100,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Sorafenib
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and T... |
DB00270 | DB09132 | 1,428 | 492 | [
"DDInter993",
"DDInter797"
] | Isradipine | Gadoteric acid | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA). It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). Gadoterate meglumine has one o... | Moderate | 1 | [
[
[
1428,
24,
492
]
],
[
[
1428,
1,
1081
],
[
1081,
24,
492
]
],
[
[
1428,
40,
854
],
[
854,
24,
492
]
],
[
[
1428,
1,
1081
],
[
1081,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoteric acid"
]
],
[
[
"Isradipine",
"{u} (Compound) resembles {v} (Compound)",
"Nicardipine"
],
[
"Nicardipine",
"{u} may cause a m... | Isradipine (Compound) resembles Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Gadoteric acid
Isradipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Gadot... |
DB01041 | DB09061 | 770 | 1,627 | [
"DDInter1789",
"DDInter284"
] | Thalidomide | Cannabidiol | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
770,
24,
1627
]
],
[
[
770,
24,
609
],
[
609,
23,
1627
]
],
[
[
770,
63,
600
],
[
600,
23,
1627
]
],
[
[
770,
24,
351
],
[
351,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole ... |
DB01069 | DB01259 | 401 | 392 | [
"DDInter1533",
"DDInter1024"
] | Promethazine | Lapatinib | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
401,
24,
392
]
],
[
[
401,
6,
4973
],
[
4973,
45,
392
]
],
[
[
401,
21,
28852
],
[
28852,
60,
392
]
],
[
[
401,
24,
271
],
[
271,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Promethazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Promethazine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Lapatinib (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and ... |
DB00762 | DB12332 | 613 | 1,619 | [
"DDInter973",
"DDInter1626"
] | Irinotecan | Rucaparib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
613,
24,
1619
]
],
[
[
613,
63,
307
],
[
307,
23,
1619
]
],
[
[
613,
24,
259
],
[
259,
24,
1619
]
],
[
[
613,
24,
151
],
[
151,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept ... |
DB00586 | DB12825 | 1,512 | 1,375 | [
"DDInter537",
"DDInter1032"
] | Diclofenac | Lefamulin | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1512,
24,
1375
]
],
[
[
1512,
24,
976
],
[
976,
24,
1375
]
],
[
[
1512,
25,
1468
],
[
1468,
24,
1375
]
],
[
[
1512,
63,
251
],
[
251,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Diclofenac may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a... |
DB00987 | DB01042 | 1,224 | 1,307 | [
"DDInter461",
"DDInter1144"
] | Cytarabine (liposomal) | Melphalan | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Moderate | 1 | [
[
[
1224,
24,
1307
]
],
[
[
1224,
5,
11555
],
[
11555,
44,
1307
]
],
[
[
1224,
7,
3151
],
[
3151,
46,
1307
]
],
[
[
1224,
23,
956
],
[
956... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
]
],
[
[
"Cytarabine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan
Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Melphalan (Compound)
Cytarabine (Compound) upregulates DDB2 (Gene) and DDB2 (Gene) is upregulated by Melphalan (Co... |
DB00321 | DB00397 | 21 | 1,466 | [
"DDInter78",
"DDInter1458"
] | Amitriptyline | Phenylpropanolamine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Moderate | 1 | [
[
[
21,
24,
1466
]
],
[
[
21,
63,
73
],
[
73,
25,
1466
]
],
[
[
21,
6,
5372
],
[
5372,
45,
1466
]
],
[
[
21,
18,
8914
],
[
8914,
57,... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylpropanolamine"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may lead to a major life threatening interaction when taken with Phenylpropanolamine
Amitriptyline (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Phenylpropanolamine (Compound)
Amitrip... |
DB00574 | DB00802 | 121 | 1,322 | [
"DDInter717",
"DDInter43"
] | Fenfluramine | Alfentanil | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Major | 2 | [
[
[
121,
25,
1322
]
],
[
[
121,
25,
411
],
[
411,
1,
1322
]
],
[
[
121,
24,
868
],
[
868,
63,
1322
]
],
[
[
121,
63,
1324
],
[
1324,
... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alfentanil"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Remifentanil"
],
[
"Remifentanil",
... | Fenfluramine may lead to a major life threatening interaction when taken with Remifentanil and Remifentanil (Compound) resembles Alfentanil (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exac... |
DB06414 | DB08870 | 655 | 850 | [
"DDInter703",
"DDInter228"
] | Etravirine | Brentuximab vedotin | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
655,
24,
850
]
],
[
[
655,
63,
896
],
[
896,
24,
850
]
],
[
[
655,
24,
1033
],
[
1033,
63,
850
]
],
[
[
655,
25,
1406
],
[
1406,
... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and ... |
DB00344 | DB09291 | 1,302 | 741 | [
"DDInter1543",
"DDInter1615"
] | Protriptyline | Rolapitant | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1302,
24,
741
]
],
[
[
1302,
24,
1264
],
[
1264,
24,
741
]
],
[
[
1302,
40,
847
],
[
847,
24,
741
]
],
[
[
1302,
25,
478
],
[
478,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Protriptyline (Compound) resembles Atomoxetine (Compound) and Atomoxetine may cause a moderate interaction that cou... |
DB00814 | DB09268 | 1,171 | 1,662 | [
"DDInter1143",
"DDInter1464"
] | Meloxicam | Picosulfuric acid | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1171,
24,
1662
]
],
[
[
1171,
23,
16
],
[
16,
23,
1662
]
],
[
[
1171,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
1171,
1,
1027
],
[
1027,
... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Meloxicam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
],
... | Meloxicam may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruca... |
DB00694 | DB00872 | 51 | 1,080 | [
"DDInter485",
"DDInter438"
] | Daunorubicin | Conivaptan | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Moderate | 1 | [
[
[
51,
24,
1080
]
],
[
[
51,
24,
165
],
[
165,
40,
1080
]
],
[
[
51,
6,
8374
],
[
8374,
45,
1080
]
],
[
[
51,
21,
28769
],
[
28769,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Conivaptan (Compound)
Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Conivaptan (Compound)
Daunorubicin (Compound) causes Feeling abnormal (Side Effect) an... |
DB00927 | DB01254 | 1,559 | 1,213 | [
"DDInter712",
"DDInter484"
] | Famotidine | Dasatinib | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1559,
25,
1213
]
],
[
[
1559,
18,
10375
],
[
10375,
57,
1213
]
],
[
[
1559,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
1559,
23,
1247
],
[
... | [
[
[
"Famotidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Famotidine",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated by {v} (Compound)",... | Famotidine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dasatinib (Compound)
Famotidine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Famotidine may cause a minor interaction that can limit clinic... |
DB00358 | DB06699 | 1,010 | 774 | [
"DDInter1140",
"DDInter493"
] | Mefloquine | Degarelix | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1010,
24,
774
]
],
[
[
1010,
63,
521
],
[
521,
1,
774
]
],
[
[
1010,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1010,
23,
112
],
[
112,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Mefloquine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Mefloquine may cause a minor interaction that ca... |
DB00881 | DB01390 | 954 | 1,117 | [
"DDInter1554",
"DDInter1683"
] | Quinapril | Sodium bicarbonate | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
954,
23,
1117
]
],
[
[
954,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
954,
24,
1220
],
[
1220,
23,
1117
]
],
[
[
954,
40,
1638
],
[
1638... | [
[
[
"Quinapril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Quinapril",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is caus... | Quinapril (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with S... |
DB01072 | DB08881 | 915 | 868 | [
"DDInter129",
"DDInter1925"
] | Atazanavir | Vemurafenib | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
915,
24,
868
]
],
[
[
915,
6,
8374
],
[
8374,
45,
868
]
],
[
[
915,
21,
29015
],
[
29015,
60,
868
]
],
[
[
915,
63,
608
],
[
608,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Atazanavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Atazanavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Atazanavir (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Vemurafenib (Compound)
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine a... |
DB01041 | DB01221 | 770 | 1,190 | [
"DDInter1789",
"DDInter1007"
] | Thalidomide | Ketamine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
770,
24,
1190
]
],
[
[
770,
6,
6017
],
[
6017,
45,
1190
]
],
[
[
770,
21,
28642
],
[
28642,
60,
1190
]
],
[
[
770,
24,
649
],
[
649,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Thalidomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ketamine (Compound)
Thalidomide (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Ketamine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol ma... |
DB00734 | DB01177 | 1,664 | 77 | [
"DDInter1605",
"DDInter904"
] | Risperidone | Idarubicin | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1664,
24,
77
]
],
[
[
1664,
6,
12523
],
[
12523,
45,
77
]
],
[
[
1664,
21,
28931
],
[
28931,
60,
77
]
],
[
[
1664,
23,
112
],
[
112,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Risperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Risperidone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Risperidone (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00736 | DB06817 | 660 | 809 | [
"DDInter676",
"DDInter1563"
] | Esomeprazole | Raltegravir | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. | Minor | 0 | [
[
[
660,
23,
809
]
],
[
[
660,
21,
29122
],
[
29122,
60,
809
]
],
[
[
660,
1,
379
],
[
379,
23,
809
]
],
[
[
660,
24,
478
],
[
478,
... | [
[
[
"Esomeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Raltegravir"
]
],
[
[
"Esomeprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Mediastinal disorder"
],
[
"Mediastinal disorder",
"... | Esomeprazole (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Raltegravir (Compound)
Esomeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole may cause a minor interaction that can limit clinical effects when taken with Raltegravir
Esomeprazole may... |
DB06210 | DB11255 | 72 | 1,371 | [
"DDInter631",
"DDInter374"
] | Eltrombopag | Chromium picolinate | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
72,
24,
1371
]
],
[
[
72,
63,
473
],
[
473,
24,
1371
]
],
[
[
72,
24,
1292
],
[
1292,
24,
1371
]
],
[
[
72,
63,
473
],
[
473,
24... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Deferipr... |
DB00450 | DB00927 | 78 | 1,559 | [
"DDInter603",
"DDInter712"
] | Droperidol | Famotidine | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
78,
24,
1559
]
],
[
[
78,
21,
28787
],
[
28787,
60,
1559
]
],
[
[
78,
24,
286
],
[
286,
62,
1559
]
],
[
[
78,
23,
112
],
[
112,
... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Droperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is ca... | Droperidol (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Famotidine (Compound)
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when ... |
DB01267 | DB06335 | 519 | 761 | [
"DDInter1381",
"DDInter1646"
] | Paliperidone | Saxagliptin | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
519,
24,
761
]
],
[
[
519,
6,
7524
],
[
7524,
45,
761
]
],
[
[
519,
21,
28966
],
[
28966,
60,
761
]
],
[
[
519,
24,
1491
],
[
1491,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Paliperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compou... | Paliperidone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Saxagliptin (Compound)
Paliperidone (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Paliperidone may cause a moderate interaction that could... |
DB00860 | DB09082 | 891 | 659 | [
"DDInter1513",
"DDInter1934"
] | Prednisolone | Vilanterol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Minor | 0 | [
[
[
891,
23,
659
]
],
[
[
891,
40,
1220
],
[
1220,
23,
659
]
],
[
[
891,
1,
423
],
[
423,
23,
659
]
],
[
[
891,
24,
1296
],
[
1296,
... | [
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vilanterol"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
"{u} may cause a... | Prednisolone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Prednisolone (Compound) resembles Ciclesonide (Compound) and Ciclesonide may cause a minor interaction that can limit clinical effects when taken with Vil... |
DB01244 | DB06691 | 762 | 849 | [
"DDInter192",
"DDInter1155"
] | Bepridil | Mepyramine | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
762,
24,
849
]
],
[
[
762,
1,
832
],
[
832,
24,
849
]
],
[
[
762,
6,
12523
],
[
12523,
45,
849
]
],
[
[
762,
63,
770
],
[
770,
2... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Bepridil",
"{u} (Compound) resembles {v} (Compound)",
"Tripelennamine"
],
[
"Tripelennamine",
"{u} may cause a mod... | Bepridil (Compound) resembles Tripelennamine (Compound) and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Bepridil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Bepridil may cause a moderate interaction that could exacerbat... |
DB06697 | DB09118 | 436 | 1,580 | [
"DDInter121",
"DDInter1711"
] | Artemether | Stiripentol | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
436,
24,
1580
]
],
[
[
436,
24,
283
],
[
283,
63,
1580
]
],
[
[
436,
24,
98
],
[
98,
24,
1580
]
],
[
[
436,
63,
1324
],
[
1324,
... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Artemether may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Artemether may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatre... |
DB00431 | DB01267 | 1,503 | 519 | [
"DDInter1072",
"DDInter1381"
] | Lindane | Paliperidone | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1503,
24,
519
]
],
[
[
1503,
24,
1664
],
[
1664,
1,
519
]
],
[
[
1503,
21,
28921
],
[
28921,
60,
519
]
],
[
[
1503,
63,
1648
],
[
1648... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Lindane (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Paliperidone (Compound)
Lindane may cause a moderate interaction tha... |
DB00099 | DB11581 | 440 | 1,456 | [
"DDInter735",
"DDInter1926"
] | Filgrastim | Venetoclax | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
440,
24,
1456
]
],
[
[
440,
24,
594
],
[
594,
24,
1456
]
],
[
[
440,
24,
738
],
[
738,
63,
1456
]
],
[
[
440,
63,
599
],
[
599,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib... |
DB01208 | DB01229 | 945 | 973 | [
"DDInter1705",
"DDInter1378"
] | Sparfloxacin | Paclitaxel (protein-bound) | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Minor | 0 | [
[
[
945,
23,
973
]
],
[
[
945,
6,
4973
],
[
4973,
45,
973
]
],
[
[
945,
18,
3833
],
[
3833,
46,
973
]
],
[
[
945,
6,
3199
],
[
3199,
... | [
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Paclitaxel"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Paclitaxel
Sparfloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paclitaxel (Compound)
Sparfloxacin (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is upregulated by Paclitaxel (Compound)
Sparfloxacin (Co... |
DB08860 | DB09065 | 788 | 760 | [
"DDInter1479",
"DDInter424"
] | Pitavastatin | Cobicistat | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
788,
24,
760
]
],
[
[
788,
74,
14
],
[
14,
24,
760
]
],
[
[
788,
24,
466
],
[
466,
63,
760
]
],
[
[
788,
24,
1040
],
[
1040,
24,... | [
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Pitavastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when tak... | Pitavastatin (Compound) resembles Rosuvastatin (Compound) and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Pitavastatin may cause a moderate interactio... |
DB06616 | DB13074 | 594 | 877 | [
"DDInter224",
"DDInter1110"
] | Bosutinib | Macimorelin | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
594,
25,
877
]
],
[
[
594,
62,
112
],
[
112,
23,
877
]
],
[
[
594,
24,
1320
],
[
1320,
24,
877
]
],
[
[
594,
64,
651
],
[
651,
2... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Bosutinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Bosutinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagoli... |
DB00692 | DB01156 | 274 | 593 | [
"DDInter1448",
"DDInter252"
] | Phentolamine | Bupropion | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
274,
24,
593
]
],
[
[
274,
18,
10375
],
[
10375,
57,
593
]
],
[
[
274,
21,
29220
],
[
29220,
60,
593
]
],
[
[
274,
63,
536
],
[
536,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Phentolamine",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated ... | Phentolamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Bupropion (Compound)
Phentolamine (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Bupropion (Compound)
Phentolamine may cause a moderate interaction that could exacerbate di... |
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