drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB03404 | DB06603 | 765 | 39 | [
"DDInter855",
"DDInter1387"
] | Hemin | Panobinostat | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
765,
24,
39
]
],
[
[
765,
24,
578
],
[
578,
63,
39
]
],
[
[
765,
64,
536
],
[
536,
24,
39
]
],
[
[
765,
63,
383
],
[
383,
24,
... | [
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Tic... | Hemin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Hemin may lead to a major life threatening interaction when taken with Secobarbital and Secobarbital may cause a mo... |
DB00418 | DB00471 | 536 | 201 | [
"DDInter1650",
"DDInter1242"
] | Secobarbital | Montelukast | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Moderate | 1 | [
[
[
536,
24,
201
]
],
[
[
536,
6,
3486
],
[
3486,
45,
201
]
],
[
[
536,
21,
28787
],
[
28787,
60,
201
]
],
[
[
536,
24,
1220
],
[
1220,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Montelukast"
]
],
[
[
"Secobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compou... | Secobarbital (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Montelukast (Compound)
Secobarbital (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Montelukast (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Dexametha... |
DB05812 | DB09183 | 1,374 | 1,641 | [
"DDInter8",
"DDInter483"
] | Abiraterone | Dasabuvir | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in ... | Moderate | 1 | [
[
[
1374,
24,
1641
]
]
] | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasabuvir"
]
]
] | |
DB01041 | DB11730 | 770 | 351 | [
"DDInter1789",
"DDInter1588"
] | Thalidomide | Ribociclib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
770,
24,
351
]
],
[
[
770,
63,
112
],
[
112,
23,
351
]
],
[
[
770,
24,
222
],
[
222,
23,
351
]
],
[
[
770,
24,
310
],
[
310,
24,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and... |
DB00373 | DB00586 | 461 | 1,512 | [
"DDInter1809",
"DDInter537"
] | Timolol | Diclofenac | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
461,
24,
1512
]
],
[
[
461,
6,
4973
],
[
4973,
45,
1512
]
],
[
[
461,
5,
11610
],
[
11610,
49,
1512
]
],
[
[
461,
21,
31774
],
[
31774... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Timolol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"... | Timolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Diclofenac (Compound)
Timolol (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Diclofenac (Compound)
Timolol (Compound) causes Corneal disorder (Side Effect) and Corneal disorder (Side Effect) is caused by Diclofenac (Compound... |
DB01268 | DB11730 | 1,151 | 351 | [
"DDInter1731",
"DDInter1588"
] | Sunitinib | Ribociclib | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1151,
25,
351
]
],
[
[
1151,
62,
1247
],
[
1247,
23,
351
]
],
[
[
1151,
24,
283
],
[
283,
62,
351
]
],
[
[
1151,
24,
1627
],
[
1627,
... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Sunitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamet... | Sunitinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and ... |
DB00055 | DB06441 | 834 | 936 | [
"DDInter605",
"DDInter283"
] | Drotrecogin alfa | Cangrelor | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Major | 2 | [
[
[
834,
25,
936
]
],
[
[
834,
23,
944
],
[
944,
62,
936
]
],
[
[
834,
25,
97
],
[
97,
24,
936
]
],
[
[
834,
24,
383
],
[
383,
24,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cangrelor"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Ch... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Drotrecogin alfa may lead to a major life threatening interaction when taken with Oxaprozin and Oxaprozin may cau... |
DB01229 | DB05679 | 973 | 1,683 | [
"DDInter1378",
"DDInter1907"
] | Paclitaxel (protein-bound) | Ustekinumab | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
973,
24,
1683
]
],
[
[
973,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
973,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
973,
63,
33
],
[
33,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Paclitaxel m... |
DB00673 | DB04868 | 723 | 478 | [
"DDInter112",
"DDInter1293"
] | Aprepitant | Nilotinib | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
723,
24,
478
]
],
[
[
723,
24,
1468
],
[
1468,
63,
478
]
],
[
[
723,
6,
6017
],
[
6017,
45,
478
]
],
[
[
723,
21,
28963
],
[
28963,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Aprepitant (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Aprepitant (Compound) ... |
DB00348 | DB01118 | 254 | 33 | [
"DDInter1300",
"DDInter76"
] | Nitisinone | Amiodarone | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
254,
24,
33
]
],
[
[
254,
24,
540
],
[
540,
1,
33
]
],
[
[
254,
21,
29005
],
[
29005,
60,
33
]
],
[
[
254,
24,
597
],
[
597,
24,... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Nitisinone (Compound) causes Dermatitis exfoliative (Side Effect) and Dermatitis exfoliative (Side Effect) is caused by Amiodarone (Compound)
Nitisinone may c... |
DB01227 | DB06209 | 1,301 | 256 | [
"DDInter1043",
"DDInter1508"
] | Levacetylmethadol | Prasugrel | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
1301,
24,
256
]
],
[
[
1301,
6,
8374
],
[
8374,
45,
256
]
],
[
[
1301,
64,
752
],
[
752,
23,
256
]
],
[
[
1301,
75,
888
],
[
888,
... | [
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Levacetylmethadol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Levacetylmethadol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prasugrel (Compound)
Levacetylmethadol may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Levacetylmethadol (Comp... |
DB01234 | DB12015 | 1,220 | 1,033 | [
"DDInter513",
"DDInter53"
] | Dexamethasone | Alpelisib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1220,
24,
1033
]
],
[
[
1220,
24,
1135
],
[
1135,
23,
1033
]
],
[
[
1220,
24,
1254
],
[
1254,
24,
1033
]
],
[
[
1220,
64,
576
],
[
576... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine an... |
DB00095 | DB00361 | 66 | 134 | [
"DDInter623",
"DDInter1939"
] | Efalizumab | Vinorelbine | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
66,
24,
134
]
],
[
[
66,
24,
147
],
[
147,
63,
134
]
],
[
[
66,
24,
1101
],
[
1101,
24,
134
]
],
[
[
66,
63,
599
],
[
599,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bex... |
DB00468 | DB06228 | 1,424 | 792 | [
"DDInter1557",
"DDInter1609"
] | Quinine | Rivaroxaban | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1424,
24,
792
]
],
[
[
1424,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1424,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1424,
23,
307
],
[
307,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Quinine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Quinine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Quinine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may caus... |
DB00603 | DB08907 | 303 | 1,344 | [
"DDInter1137",
"DDInter280"
] | Medroxyprogesterone acetate | Canagliflozin | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
303,
24,
1344
]
],
[
[
303,
24,
549
],
[
549,
1,
1344
]
],
[
[
303,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
303,
21,
28962
],
[
28962,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Medroxyprogesterone acetate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Medroxyprogesterone ... |
DB08815 | DB08899 | 154 | 129 | [
"DDInter1104",
"DDInter649"
] | Lurasidone | Enzalutamide | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
154,
25,
129
]
],
[
[
154,
63,
918
],
[
918,
1,
129
]
],
[
[
154,
6,
8374
],
[
8374,
45,
129
]
],
[
[
154,
21,
28703
],
[
28703,
... | [
[
[
"Lurasidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"Bicalu... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Lurasidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Lurasidone (Compound) causes Pruritus (Side Effect) and Pr... |
DB06168 | DB06650 | 1,531 | 1,500 | [
"DDInter281",
"DDInter1324"
] | Canakinumab | Ofatumumab | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Moderate | 1 | [
[
[
1531,
24,
1500
]
],
[
[
1531,
24,
270
],
[
270,
63,
1500
]
],
[
[
1531,
63,
869
],
[
869,
24,
1500
]
],
[
[
1531,
24,
259
],
[
259,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofatumumab"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],
[... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Ofatumumab
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Top... |
DB00290 | DB06643 | 329 | 1,136 | [
"DDInter219",
"DDInter500"
] | Bleomycin | Denosumab | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
329,
24,
1136
]
],
[
[
329,
24,
1555
],
[
1555,
24,
1136
]
],
[
[
329,
63,
1648
],
[
1648,
24,
1136
]
],
[
[
329,
25,
1377
],
[
1377,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesl... |
DB00363 | DB11186 | 695 | 1,609 | [
"DDInter419",
"DDInter1427"
] | Clozapine | Pentoxyverine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
695,
24,
1609
]
],
[
[
695,
1,
623
],
[
623,
24,
1609
]
],
[
[
695,
24,
104
],
[
104,
24,
1609
]
],
[
[
695,
25,
1264
],
[
1264,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Clozapine",
"{u} (Compound) resembles {v} (Compound)",
"Quetiapine"
],
[
"Quetiapine",
"{u} may cause a modera... | Clozapine (Compound) resembles Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that ... |
DB00227 | DB06595 | 1,463 | 1,491 | [
"DDInter1098",
"DDInter1214"
] | Lovastatin | Midostaurin | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1463,
24,
1491
]
],
[
[
1463,
24,
112
],
[
112,
23,
1491
]
],
[
[
1463,
63,
58
],
[
58,
24,
1491
]
],
[
[
1463,
24,
1017
],
[
1017,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Al... |
DB08820 | DB11952 | 1,478 | 800 | [
"DDInter997",
"DDInter612"
] | Ivacaftor | Duvelisib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Major | 2 | [
[
[
1478,
25,
800
]
],
[
[
1478,
63,
310
],
[
310,
24,
800
]
],
[
[
1478,
24,
1476
],
[
1476,
63,
800
]
],
[
[
1478,
24,
1496
],
[
1496,
... | [
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duvelisib"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel"... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigati... |
DB00533 | DB09135 | 1,416 | 1,211 | [
"DDInter1613",
"DDInter967"
] | Rofecoxib | Ioxilan | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1416,
25,
1211
]
],
[
[
1416,
24,
712
],
[
712,
25,
1211
]
],
[
[
1416,
63,
91
],
[
91,
25,
1211
]
],
[
[
1416,
25,
629
],
[
629,
... | [
[
[
"Rofecoxib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
"Olsalazine",
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Ioxilan
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may lead to a m... |
DB00765 | DB00902 | 1,266 | 104 | [
"DDInter1205",
"DDInter1168"
] | Metyrosine | Methdilazine | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1266,
24,
104
]
],
[
[
1266,
63,
13
],
[
13,
24,
104
]
],
[
[
1266,
24,
820
],
[
820,
1,
104
]
],
[
[
1266,
24,
537
],
[
537,
40... | [
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB01309 | DB08882 | 1,254 | 1,281 | [
"DDInter933",
"DDInter1070"
] | Insulin glulisine | Linagliptin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1254,
24,
1281
]
],
[
[
1254,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1254,
62,
1103
],
[
1103,
23,
1281
]
],
[
[
1254,
24,
1060
],
[
106... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Insulin glulisine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction ... |
DB01276 | DB06788 | 123 | 1,616 | [
"DDInter706",
"DDInter864"
] | Exenatide | Histrelin | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
123,
24,
1616
]
],
[
[
123,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
123,
24,
4
],
[
4,
24,
1616
]
],
[
[
123,
24,
1296
],
[
1296,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Histrelin
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccin... |
DB00557 | DB00662 | 252 | 717 | [
"DDInter895",
"DDInter1873"
] | Hydroxyzine | Trimethobenzamide | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
252,
24,
717
]
],
[
[
252,
25,
1425
],
[
1425,
40,
717
]
],
[
[
252,
21,
28762
],
[
28762,
60,
717
]
],
[
[
252,
40,
1630
],
[
1630,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Hydroxyzine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
],
[
"Ci... | Hydroxyzine may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Trimethobenzamide (Compound)
Hydroxyzine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Trimethobenzamide (Compound)
Hydroxyzine (Compound) resembles Perphenazine (... |
DB01203 | DB01211 | 699 | 609 | [
"DDInter1255",
"DDInter393"
] | Nadolol | Clarithromycin | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
699,
23,
609
]
],
[
[
699,
6,
4973
],
[
4973,
45,
609
]
],
[
[
699,
21,
29169
],
[
29169,
60,
609
]
],
[
[
699,
63,
752
],
[
752,
... | [
[
[
"Nadolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Nadolol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nadolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Nadolol (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Clarithromycin (Compound)
Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidin... |
DB00574 | DB04868 | 121 | 478 | [
"DDInter717",
"DDInter1293"
] | Fenfluramine | Nilotinib | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
121,
24,
478
]
],
[
[
121,
24,
1468
],
[
1468,
63,
478
]
],
[
[
121,
24,
271
],
[
271,
62,
478
]
],
[
[
121,
23,
479
],
[
479,
2... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirab... |
DB00056 | DB09498 | 816 | 810 | [
"DDInter814",
"DDInter1715"
] | Gemtuzumab ozogamicin | Strontium chloride Sr-89 | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
816,
24,
810
]
],
[
[
816,
24,
597
],
[
597,
24,
810
]
],
[
[
816,
24,
738
],
[
738,
63,
810
]
],
[
[
816,
25,
770
],
[
770,
24,... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate ... |
DB00679 | DB06282 | 684 | 516 | [
"DDInter1796",
"DDInter1053"
] | Thioridazine | Levocetirizine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
684,
24,
516
]
],
[
[
684,
63,
701
],
[
701,
24,
516
]
],
[
[
684,
40,
1178
],
[
1178,
24,
516
]
],
[
[
684,
24,
407
],
[
407,
6... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Thioridazine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine may cause a moderate inte... |
DB01232 | DB01276 | 1,327 | 123 | [
"DDInter1640",
"DDInter706"
] | Saquinavir | Exenatide | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1327,
24,
123
]
],
[
[
1327,
25,
1476
],
[
1476,
63,
123
]
],
[
[
1327,
63,
1573
],
[
1573,
24,
123
]
],
[
[
1327,
24,
1040
],
[
1040,... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib"... | Saquinavir may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a... |
DB01116 | DB01285 | 601 | 708 | [
"DDInter1872",
"DDInter445"
] | Trimethaphan | Corticotropin | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
601,
24,
708
]
],
[
[
601,
24,
1450
],
[
1450,
63,
708
]
],
[
[
601,
63,
1648
],
[
1648,
24,
708
]
],
[
[
601,
24,
593
],
[
593,
... | [
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]... | Trimethaphan may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Trimethaphan may cause a moderate interaction that could exacerbate diseases when taken with Aldesleu... |
DB00060 | DB08868 | 912 | 1,011 | [
"DDInter947",
"DDInter737"
] | Interferon beta-1a | Fingolimod | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
912,
24,
1011
]
],
[
[
912,
24,
1247
],
[
1247,
23,
1011
]
],
[
[
912,
24,
242
],
[
242,
63,
1011
]
],
[
[
912,
24,
62
],
[
62,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethox... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01203 | DB06792 | 699 | 1,606 | [
"DDInter1255",
"DDInter1023"
] | Nadolol | Lanthanum carbonate | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
699,
24,
1606
]
],
[
[
699,
62,
1152
],
[
1152,
24,
1606
]
],
[
[
699,
40,
887
],
[
887,
24,
1606
]
],
[
[
699,
62,
1152
],
[
1152,
... | [
[
[
"Nadolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Nadolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Liothyronine"
],
[... | Nadolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Nadolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that coul... |
DB01406 | DB09143 | 984 | 313 | [
"DDInter472",
"DDInter1701"
] | Danazol | Sonidegib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Moderate | 1 | [
[
[
984,
24,
313
]
],
[
[
984,
24,
478
],
[
478,
24,
313
]
],
[
[
984,
24,
484
],
[
484,
63,
313
]
],
[
[
984,
63,
1213
],
[
1213,
2... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sonidegib"
]
],
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
"Nil... | Danazol may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sonidegib
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib ma... |
DB00188 | DB11979 | 168 | 1,320 | [
"DDInter222",
"DDInter625"
] | Bortezomib | Elagolix | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Minor | 0 | [
[
[
168,
23,
1320
]
],
[
[
168,
23,
1249
],
[
1249,
24,
1320
]
],
[
[
168,
25,
129
],
[
129,
24,
1320
]
],
[
[
168,
24,
372
],
[
372,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Elagolix"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nafcillin"
],
[
"Na... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Bortezomib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a ... |
DB00741 | DB10429 | 167 | 200 | [
"DDInter885",
"DDInter282"
] | Hydrocortisone | Candida albicans | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
167,
24,
200
]
],
[
[
167,
24,
1683
],
[
1683,
24,
200
]
],
[
[
167,
25,
976
],
[
976,
24,
200
]
],
[
[
167,
1,
1486
],
[
1486,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Hydrocortisone may lead to a major life threatening interaction when taken with Tofacitinib and Tofa... |
DB00748 | DB05541 | 662 | 801 | [
"DDInter297",
"DDInter239"
] | Carbinoxamine | Brivaracetam | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
662,
24,
801
]
],
[
[
662,
63,
475
],
[
475,
24,
801
]
],
[
[
662,
35,
100
],
[
100,
24,
801
]
],
[
[
662,
24,
1264
],
[
1264,
2... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam
Carbinoxamine (Compound) resembles Brompheniramine (Compound) and Carbinoxamine may cause a moderate interactio... |
DB01041 | DB11003 | 770 | 748 | [
"DDInter1789",
"DDInter100"
] | Thalidomide | Anthrax vaccine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
770,
24,
748
]
],
[
[
770,
64,
322
],
[
322,
24,
748
]
],
[
[
770,
63,
168
],
[
168,
24,
748
]
],
[
[
770,
25,
676
],
[
676,
63,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
],
[
"Epi... | Thalidomide may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may... |
DB00004 | DB14409 | 669 | 1,129 | [
"DDInter499",
"DDInter867"
] | Denileukin diftitox | Human adenovirus e serotype 4 strain cl-68578 antigen | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
669,
24,
1129
]
],
[
[
669,
25,
1057
],
[
1057,
24,
1129
]
],
[
[
669,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
669,
25,
676
],
[
676,
... | [
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken... | Denileukin diftitox may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Denileukin diftitox may cause a moderate interaction that could exacerbate ... |
DB00968 | DB06292 | 1,551 | 549 | [
"DDInter1185",
"DDInter474"
] | Methyldopa | Dapagliflozin | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1551,
24,
549
]
],
[
[
1551,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1551,
21,
28882
],
[
28882,
60,
549
]
],
[
[
1551,
63,
1636
],
[
163... | [
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Methyldopa (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dapagliflozin (Compound... |
DB01136 | DB01156 | 772 | 593 | [
"DDInter305",
"DDInter252"
] | Carvedilol | Bupropion | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
772,
24,
593
]
],
[
[
772,
6,
8374
],
[
8374,
45,
593
]
],
[
[
772,
21,
29243
],
[
29243,
60,
593
]
],
[
[
772,
63,
752
],
[
752,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Carvedilol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Carvedilol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Carvedilol (Compound) causes Wheezing (Side Effect) and Wheezing (Side Effect) is caused by Bupropion (Compound)
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidi... |
DB00570 | DB00705 | 147 | 441 | [
"DDInter1936",
"DDInter496"
] | Vinblastine | Delavirdine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Major | 2 | [
[
[
147,
25,
441
]
],
[
[
147,
6,
12523
],
[
12523,
45,
441
]
],
[
[
147,
21,
28709
],
[
28709,
60,
441
]
],
[
[
147,
62,
63
],
[
63,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Dela... | Vinblastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Delavirdine (Compound)
Vinblastine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Vinblastine may cause a minor interaction that can limit clinical effects when taken wit... |
DB00496 | DB14723 | 194 | 159 | [
"DDInter480",
"DDInter1026"
] | Darifenacin | Larotrectinib | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
194,
24,
159
]
],
[
[
194,
24,
741
],
[
741,
24,
159
]
],
[
[
194,
63,
597
],
[
597,
24,
159
]
],
[
[
194,
25,
888
],
[
888,
24,... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol ... |
DB00363 | DB06335 | 695 | 761 | [
"DDInter419",
"DDInter1646"
] | Clozapine | Saxagliptin | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
695,
24,
761
]
],
[
[
695,
6,
8374
],
[
8374,
45,
761
]
],
[
[
695,
25,
1491
],
[
1491,
63,
761
]
],
[
[
695,
24,
104
],
[
104,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Clozapine may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Clozapine may cause a moderate ... |
DB01192 | DB11186 | 560 | 1,609 | [
"DDInter1372",
"DDInter1427"
] | Oxymorphone | Pentoxyverine | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
560,
24,
1609
]
],
[
[
560,
40,
314
],
[
314,
24,
1609
]
],
[
[
560,
63,
104
],
[
104,
24,
1609
]
],
[
[
560,
24,
649
],
[
649,
... | [
[
[
"Oxymorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Oxymorphone",
"{u} (Compound) resembles {v} (Compound)",
"Nalbuphine"
],
[
"Nalbuphine",
"{u} may cause a mo... | Oxymorphone (Compound) resembles Nalbuphine (Compound) and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Oxymorphone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction t... |
DB00446 | DB14879 | 597 | 163 | [
"DDInter351",
"DDInter318"
] | Chloramphenicol | Cefiderocol | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to ... | Moderate | 1 | [
[
[
597,
24,
163
]
],
[
[
597,
24,
126
],
[
126,
24,
163
]
],
[
[
597,
24,
126
],
[
126,
25,
405
],
[
405,
24,
163
]
],
[
[
597,
24,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefiderocol"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefiderocol
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and W... |
DB00445 | DB10316 | 322 | 334 | [
"DDInter655",
"DDInter1248"
] | Epirubicin | Mumps virus strain B level jeryl lynn live antigen | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
322,
25,
334
]
],
[
[
322,
64,
1057
],
[
1057,
25,
334
]
],
[
[
322,
24,
328
],
[
328,
25,
334
]
],
[
[
322,
25,
908
],
[
908,
2... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Epirubicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopur... |
DB00001 | DB09420 | 1,578 | 1,074 | [
"DDInter1037",
"DDInter953"
] | Lepirudin | Iodide I-123 | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1578,
24,
1074
]
],
[
[
1578,
25,
500
],
[
500,
24,
1074
]
],
[
[
1578,
24,
1004
],
[
1004,
63,
1074
]
],
[
[
1578,
24,
1479
],
[
1479... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
"Enoxaparin... | Lepirudin may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicyl... |
DB01064 | DB01236 | 1,148 | 679 | [
"DDInter987",
"DDInter1664"
] | Isoprenaline | Sevoflurane | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Moderate | 1 | [
[
[
1148,
24,
679
]
],
[
[
1148,
63,
1262
],
[
1262,
40,
679
]
],
[
[
1148,
21,
28751
],
[
28751,
60,
679
]
],
[
[
1148,
24,
484
],
[
484,... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) resembles Sevoflurane (Compound)
Isoprenaline (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Sevoflurane (Compound)
Isoprenaline may cause a moderate in... |
DB00593 | DB01619 | 1,464 | 830 | [
"DDInter695",
"DDInter1441"
] | Ethosuximide | Phenindamine | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1464,
24,
830
]
],
[
[
1464,
24,
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],
[
1219,
40,
830
]
],
[
[
1464,
63,
13
],
[
13,
24,
830
]
],
[
[
1464,
24,
104
],
[
104,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
],
... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound)
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interactio... |
DB00334 | DB01612 | 867 | 1,637 | [
"DDInter1326",
"DDInter92"
] | Olanzapine | Amyl Nitrite | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
867,
24,
1637
]
],
[
[
867,
64,
475
],
[
475,
24,
1637
]
],
[
[
867,
24,
401
],
[
401,
24,
1637
]
],
[
[
867,
25,
593
],
[
593,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Olanzapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphine",... | Olanzapine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may caus... |
DB00242 | DB08885 | 1,064 | 363 | [
"DDInter392",
"DDInter33"
] | Cladribine | Aflibercept | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Dalt... | Major | 2 | [
[
[
1064,
25,
363
]
],
[
[
1064,
25,
1531
],
[
1531,
24,
363
]
],
[
[
1064,
24,
151
],
[
151,
63,
363
]
],
[
[
1064,
64,
58
],
[
58,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aflibercept"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Canakinumab"
],
[
"Canakinumab",
"{u... | Cladribine may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Aflibercept
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/... |
DB02546 | DB06292 | 137 | 549 | [
"DDInter1947",
"DDInter474"
] | Vorinostat | Dapagliflozin | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
137,
24,
549
]
],
[
[
137,
24,
1344
],
[
1344,
40,
549
]
],
[
[
137,
21,
28882
],
[
28882,
60,
549
]
],
[
[
137,
63,
1179
],
[
1179,
... | [
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Vorinostat may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Vorinostat (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dapagliflozin (Compound... |
DB01035 | DB09020 | 1,401 | 28 | [
"DDInter1524",
"DDInter212"
] | Procainamide | Bisacodyl | A derivative of procaine with less CNS action. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1401,
24,
28
]
],
[
[
1401,
21,
28809
],
[
28809,
60,
28
]
],
[
[
1401,
25,
823
],
[
823,
63,
28
]
],
[
[
1401,
25,
1250
],
[
1250,
... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Procainamide",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is c... | Procainamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound)
Procainamide may lead to a major life threatening interaction when taken with Triclabendazole and Triclabendazole may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl... |
DB00835 | DB01619 | 100 | 830 | [
"DDInter245",
"DDInter1441"
] | Brompheniramine | Phenindamine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
100,
24,
830
]
],
[
[
100,
63,
1251
],
[
1251,
1,
830
]
],
[
[
100,
24,
537
],
[
537,
40,
830
]
],
[
[
100,
63,
1219
],
[
1219,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mirtazapine and Mirtazapine (Compound) resembles Phenindamine (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindami... |
DB00377 | DB00816 | 1,494 | 1,674 | [
"DDInter1382",
"DDInter1346"
] | Palonosetron | Orciprenaline | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1494,
24,
1674
]
],
[
[
1494,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
1494,
25,
1164
],
[
1164,
24,
1674
]
],
[
[
1494,
64,
534
],
[
5... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Palonosetron",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) ... | Palonosetron (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Palonosetron may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenali... |
DB00862 | DB12130 | 1,005 | 1,017 | [
"DDInter1918",
"DDInter1094"
] | Vardenafil | Lorlatinib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1005,
24,
1017
]
],
[
[
1005,
24,
1491
],
[
1491,
24,
1017
]
],
[
[
1005,
63,
888
],
[
888,
24,
1017
]
],
[
[
1005,
64,
11
],
[
11,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
[
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamox... |
DB00635 | DB01165 | 1,573 | 1,539 | [
"DDInter1515",
"DDInter1325"
] | Prednisone | Ofloxacin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
1573,
25,
1539
]
],
[
[
1573,
64,
1467
],
[
1467,
1,
1539
]
],
[
[
1573,
25,
945
],
[
945,
40,
1539
]
],
[
[
1573,
25,
739
],
[
739,
... | [
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxacin"
],
[
"Enoxacin",
"{u} (Compo... | Prednisone may lead to a major life threatening interaction when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Prednisone may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Prednisone may lead to a major l... |
DB08880 | DB12457 | 1,510 | 1,180 | [
"DDInter1771",
"DDInter1598"
] | Teriflunomide | Rimegepant | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
1510,
24,
1180
]
],
[
[
1510,
24,
741
],
[
741,
24,
1180
]
],
[
[
1510,
25,
1619
],
[
1619,
24,
1180
]
],
[
[
1510,
64,
1419
],
[
1419... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Teriflunomide may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may ca... |
DB00987 | DB11601 | 1,224 | 1,270 | [
"DDInter460",
"DDInter1889"
] | Cytarabine | Tuberculin purified protein derivative | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1224,
24,
1270
]
],
[
[
1224,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
1224,
76,
1064
],
[
1064,
24,
1270
]
],
[
[
1224,
63,
1555
],
[
15... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Cytarabine may cause a moderate interaction that could exacerbate diseases when ta... |
DB08901 | DB10429 | 1,468 | 200 | [
"DDInter1492",
"DDInter282"
] | Ponatinib | Candida albicans | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1468,
24,
200
]
],
[
[
1468,
63,
1683
],
[
1683,
24,
200
]
],
[
[
1468,
64,
976
],
[
976,
24,
200
]
],
[
[
1468,
25,
375
],
[
375,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Ponatinib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB06706 | DB08918 | 468 | 41 | [
"DDInter985",
"DDInter1059"
] | Isometheptene | Levomilnacipran | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
468,
24,
41
]
],
[
[
468,
63,
901
],
[
901,
40,
41
]
],
[
[
468,
63,
1674
],
[
1674,
24,
41
]
],
[
[
468,
24,
144
],
[
144,
63,
... | [
[
[
"Isometheptene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Isometheptene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
... | Isometheptene may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Isometheptene may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a moderate int... |
DB01235 | DB09481 | 1,191 | 460 | [
"DDInter1054",
"DDInter1113"
] | Levodopa | Magnesium carbonate | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1191,
23,
460
]
],
[
[
1191,
63,
401
],
[
401,
23,
460
]
],
[
[
1191,
24,
1468
],
[
1468,
23,
460
]
],
[
[
1191,
63,
14
],
[
14,
... | [
[
[
"Levodopa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and ... |
DB00748 | DB01246 | 662 | 820 | [
"DDInter297",
"DDInter45"
] | Carbinoxamine | Alimemazine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
662,
24,
820
]
],
[
[
662,
35,
358
],
[
358,
24,
820
]
],
[
[
662,
24,
104
],
[
104,
40,
820
]
],
[
[
662,
1,
11275
],
[
11275,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when ... | Carbinoxamine (Compound) resembles Orphenadrine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Carbinoxamine may cause a moderate intera... |
DB00783 | DB00994 | 1,438 | 361 | [
"DDInter679",
"DDInter1277"
] | Estradiol | Neomycin | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Moderate | 1 | [
[
[
1438,
24,
361
]
],
[
[
1438,
63,
1647
],
[
1647,
24,
361
]
],
[
[
1438,
21,
28722
],
[
28722,
60,
361
]
],
[
[
1438,
24,
1132
],
[
113... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
"A... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Estradiol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Estradiol ma... |
DB00333 | DB00377 | 576 | 1,494 | [
"DDInter1166",
"DDInter1382"
] | Methadone | Palonosetron | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Major | 2 | [
[
[
576,
25,
1494
]
],
[
[
576,
6,
17589
],
[
17589,
45,
1494
]
],
[
[
576,
21,
28900
],
[
28900,
60,
1494
]
],
[
[
576,
23,
112
],
[
112,... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palonosetron"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"HTR3A"
],
[
"HTR3A",
"{u} (Gene) is bound by {v} (Compound)",
"Palonoset... | Methadone (Compound) binds HTR3A (Gene) and HTR3A (Gene) is bound by Palonosetron (Compound)
Methadone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Palonosetron (Compound)
Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazol... |
DB00861 | DB06754 | 914 | 707 | [
"DDInter551",
"DDInter471"
] | Diflunisal | Danaparoid | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
914,
25,
707
]
],
[
[
914,
63,
121
],
[
121,
24,
707
]
],
[
[
914,
24,
222
],
[
222,
24,
707
]
],
[
[
914,
24,
116
],
[
116,
63,... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
[
"Fenflura... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and S... |
DB00334 | DB01278 | 867 | 1,021 | [
"DDInter1326",
"DDInter1506"
] | Olanzapine | Pramlintide | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
867,
24,
1021
]
],
[
[
867,
24,
1507
],
[
1507,
24,
1021
]
],
[
[
867,
1,
623
],
[
623,
24,
1021
]
],
[
[
867,
24,
1296
],
[
1296,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Olanzapine (Compound) resembles Quetiapine (Compound) and Quetiapine may cause a moderate interaction that co... |
DB01097 | DB09276 | 1,377 | 381 | [
"DDInter1033",
"DDInter1682"
] | Leflunomide | Sodium aurothiomalate | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Major | 2 | [
[
[
1377,
25,
381
]
],
[
[
1377,
25,
1683
],
[
1683,
24,
381
]
],
[
[
1377,
64,
491
],
[
491,
24,
381
]
],
[
[
1377,
63,
597
],
[
597,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ustekinumab"
],
[
"Ustekinumab... | Leflunomide may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Leflunomide may lead to a major life threatening interaction when taken with Peginterferon alfa-2a and Peginterfe... |
DB00222 | DB00344 | 245 | 1,302 | [
"DDInter825",
"DDInter1543"
] | Glimepiride | Protriptyline | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Moderate | 1 | [
[
[
245,
24,
1302
]
],
[
[
245,
24,
998
],
[
998,
1,
1302
]
],
[
[
245,
21,
29232
],
[
29232,
60,
1302
]
],
[
[
245,
24,
820
],
[
820,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Protriptyline (Compound)
Glimepiride (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Protriptyline (Compound)
Glimepiride may cause a mode... |
DB01174 | DB12015 | 697 | 1,033 | [
"DDInter1442",
"DDInter53"
] | Phenobarbital | Alpelisib | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Major | 2 | [
[
[
697,
25,
1033
]
],
[
[
697,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
697,
24,
738
],
[
738,
24,
1033
]
],
[
[
697,
25,
951
],
[
951,
... | [
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alpelisib"
]
],
[
[
"Phenobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u... | Phenobarbital may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a... |
DB06168 | DB15699 | 1,531 | 652 | [
"DDInter281",
"DDInter232"
] | Canakinumab | Brexucabtagene autoleucel | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Moderate | 1 | [
[
[
1531,
24,
652
]
],
[
[
1531,
24,
259
],
[
259,
24,
652
]
],
[
[
1531,
63,
1683
],
[
1683,
24,
652
]
],
[
[
1531,
25,
976
],
[
976,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Uste... |
DB00209 | DB14881 | 352 | 180 | [
"DDInter1886",
"DDInter1329"
] | Trospium | Oliceridine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
352,
24,
180
]
],
[
[
352,
24,
401
],
[
401,
24,
180
]
],
[
[
352,
35,
262
],
[
262,
24,
180
]
],
[
[
352,
24,
475
],
[
475,
25,... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Trospium (Compound) resembles Clidinium (Compound) and Trospium may cause a moderate interaction that could e... |
DB01238 | DB08907 | 673 | 1,344 | [
"DDInter118",
"DDInter280"
] | Aripiprazole | Canagliflozin | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
673,
24,
1344
]
],
[
[
673,
24,
549
],
[
549,
1,
1344
]
],
[
[
673,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
673,
21,
28962
],
[
28962,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Aripiprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Aripiprazole (Compound) causes Hyperkalaemia (Side E... |
DB00436 | DB11093 | 323 | 636 | [
"DDInter179",
"DDInter273"
] | Bendroflumethiazide | Calcium citrate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
323,
24,
636
]
],
[
[
323,
23,
1572
],
[
1572,
24,
636
]
],
[
[
323,
40,
504
],
[
504,
24,
636
]
],
[
[
323,
62,
964
],
[
964,
2... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demecl... | Bendroflumethiazide may cause a minor interaction that can limit clinical effects when taken with Demeclocycline and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Bendroflumethiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hydrochlorothiaz... |
DB00307 | DB11817 | 1,101 | 1,259 | [
"DDInter202",
"DDInter165"
] | Bexarotene | Baricitinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1101,
25,
1259
]
],
[
[
1101,
24,
949
],
[
949,
24,
1259
]
],
[
[
1101,
24,
1129
],
[
1129,
63,
1259
]
],
[
[
1101,
25,
1301
],
[
1301... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formal... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Bexarotene ... |
DB01110 | DB04938 | 86 | 1,423 | [
"DDInter1209",
"DDInter1353"
] | Miconazole | Ospemifene | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Moderate | 1 | [
[
[
86,
24,
1423
]
],
[
[
86,
6,
6017
],
[
6017,
45,
1423
]
],
[
[
86,
21,
28785
],
[
28785,
60,
1423
]
],
[
[
86,
24,
760
],
[
760,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ospemifene"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Miconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ospemifene (Compound)
Miconazole (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Ospemifene (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat ... |
DB00341 | DB00497 | 1,242 | 828 | [
"DDInter343",
"DDInter1366"
] | Cetirizine | Oxycodone | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
1242,
24,
828
]
],
[
[
1242,
63,
421
],
[
421,
1,
828
]
],
[
[
1242,
24,
314
],
[
314,
1,
828
]
],
[
[
1242,
24,
560
],
[
560,
4... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Oxycodone (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxycodone (Compou... |
DB04865 | DB06292 | 4 | 549 | [
"DDInter1335",
"DDInter474"
] | Omacetaxine mepesuccinate | Dapagliflozin | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
4,
24,
549
]
],
[
[
4,
24,
1344
],
[
1344,
40,
549
]
],
[
[
4,
7,
9842
],
[
9842,
45,
549
]
],
[
[
4,
25,
292
],
[
292,
62,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Omacetaxine mepesuccinate (Compound) upregulates CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dapagliflozin (Compound)
Omacetaxine mepesu... |
DB00395 | DB01181 | 210 | 1,532 | [
"DDInter301",
"DDInter906"
] | Carisoprodol | Ifosfamide | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
210,
24,
1532
]
],
[
[
210,
6,
10215
],
[
10215,
45,
1532
]
],
[
[
210,
21,
28725
],
[
28725,
60,
1532
]
],
[
[
210,
63,
1648
],
[
164... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Carisoprodol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compo... | Carisoprodol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ifosfamide (Compound)
Carisoprodol (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Ifosfamide (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Aldes... |
DB00563 | DB10989 | 663 | 496 | [
"DDInter1174",
"DDInter858"
] | Methotrexate | Hepatitis A Vaccine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
663,
24,
496
]
],
[
[
663,
24,
4
],
[
4,
24,
496
]
],
[
[
663,
24,
738
],
[
738,
63,
496
]
],
[
[
663,
63,
1101
],
[
1101,
24,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine me... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Methotrexate may cause a moderate interaction that could exacerbate dis... |
DB00985 | DB01075 | 1,443 | 1,376 | [
"DDInter562",
"DDInter569"
] | Dimenhydrinate | Diphenhydramine | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1443,
24,
1376
]
],
[
[
1443,
24,
649
],
[
649,
63,
1376
]
],
[
[
1443,
63,
128
],
[
128,
24,
1376
]
],
[
[
1443,
40,
307
],
[
307,
... | [
[
[
"Dimenhydrinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Dimenhydrinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Dexbromp... |
DB00361 | DB01265 | 134 | 1,477 | [
"DDInter1939",
"DDInter1757"
] | Vinorelbine | Telbivudine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
134,
24,
1477
]
],
[
[
134,
63,
141
],
[
141,
1,
1477
]
],
[
[
134,
24,
139
],
[
139,
1,
1477
]
],
[
[
134,
21,
28745
],
[
28745,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) resembles Telbivudine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Telbivudine (Comp... |
DB00281 | DB00615 | 608 | 690 | [
"DDInter1066",
"DDInter1589"
] | Lidocaine | Rifabutin | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Minor | 0 | [
[
[
608,
23,
690
]
],
[
[
608,
23,
463
],
[
463,
1,
690
]
],
[
[
608,
6,
8374
],
[
8374,
45,
690
]
],
[
[
608,
21,
28734
],
[
28734,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifabutin"
]
],
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifampicin"
],
[
"Ri... | Lidocaine may cause a minor interaction that can limit clinical effects when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Lidocaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Lidocaine (Compound) causes Immune system disorder (Side Effect) and Imm... |
DB06674 | DB08870 | 908 | 850 | [
"DDInter837",
"DDInter228"
] | Golimumab | Brentuximab vedotin | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Major | 2 | [
[
[
908,
25,
850
]
],
[
[
908,
24,
788
],
[
788,
24,
850
]
],
[
[
908,
63,
671
],
[
671,
24,
850
]
],
[
[
908,
24,
496
],
[
496,
63,... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[
"P... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Fluvastati... |
DB00206 | DB01124 | 1,245 | 1,411 | [
"DDInter1582",
"DDInter1828"
] | Reserpine | Tolbutamide | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1245,
24,
1411
]
],
[
[
1245,
24,
959
],
[
959,
40,
1411
]
],
[
[
1245,
18,
5818
],
[
5818,
57,
1411
]
],
[
[
1245,
21,
28680
],
[
286... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Reserpine (Compound) downregulates ATP6V0B (Gene) and ATP6V0B (Gene) is downregulated by Tolbutamide (Compound)
Reserpine (Compound) causes Rash (Side Effect) and... |
DB00524 | DB00618 | 811 | 1,572 | [
"DDInter1199",
"DDInter498"
] | Metolazone | Demeclocycline | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Minor | 0 | [
[
[
811,
23,
1572
]
],
[
[
811,
23,
1620
],
[
1620,
1,
1572
]
],
[
[
811,
62,
964
],
[
964,
1,
1572
]
],
[
[
811,
23,
1669
],
[
1669,
... | [
[
[
"Metolazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demeclocycline"
]
],
[
[
"Metolazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracycline"
],
[
... | Metolazone may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline (Compound) resembles Demeclocycline (Compound)
Metolazone may cause a minor interaction that can limit clinical effects when taken with Doxycycline and Doxycycline (Compound) resembles Demeclocycline (... |
DB00104 | DB00373 | 966 | 461 | [
"DDInter1323",
"DDInter1809"
] | Octreotide | Timolol | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Moderate | 1 | [
[
[
966,
24,
461
]
],
[
[
966,
24,
729
],
[
729,
40,
461
]
],
[
[
966,
21,
29169
],
[
29169,
60,
461
]
],
[
[
966,
24,
1450
],
[
1450,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Timolol (Compound)
Octreotide (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Timolol (Compound)
Octreotide may cause a moderate interaction that cou... |
DB00465 | DB00731 | 886 | 1,144 | [
"DDInter1010",
"DDInter1269"
] | Ketorolac | Nateglinide | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
886,
24,
1144
]
],
[
[
886,
6,
10522
],
[
10522,
45,
1144
]
],
[
[
886,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
886,
24,
121
],
[
121,... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Ketorolac",
"{u} (Compound) binds {v} (Gene)",
"PTGS1"
],
[
"PTGS1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ketorolac (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Nateglinide (Compound)
Ketorolac (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fen... |
DB01205 | DB01215 | 1,404 | 1,418 | [
"DDInter748",
"DDInter677"
] | Flumazenil | Estazolam | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
1404,
24,
1418
]
],
[
[
1404,
63,
523
],
[
523,
1,
1418
]
],
[
[
1404,
63,
1216
],
[
1216,
40,
1418
]
],
[
[
1404,
64,
87
],
[
87,
... | [
[
[
"Flumazenil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Flumazenil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Flumazenil may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Flumazenil may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Fl... |
DB00443 | DB00519 | 251 | 1,638 | [
"DDInter195",
"DDInter1843"
] | Betamethasone | Trandolapril | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
251,
24,
1638
]
],
[
[
251,
24,
954
],
[
954,
40,
1638
]
],
[
[
251,
21,
28762
],
[
28762,
60,
1638
]
],
[
[
251,
23,
1117
],
[
1117,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Betamethasone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Trandolapril (Compound)
Betamethasone may cause a minor intera... |
DB00213 | DB00451 | 837 | 542 | [
"DDInter1388",
"DDInter1064"
] | Pantoprazole | Levothyroxine | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
837,
24,
542
]
],
[
[
837,
24,
624
],
[
624,
1,
542
]
],
[
[
837,
6,
15333
],
[
15333,
45,
542
]
],
[
[
837,
21,
28957
],
[
28957,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Levothyroxine (Compound)
Pantoprazole (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Levothyroxine (Compound)
Pantoprazole (Compound) causes Arthralgia (Side Effect) and ... |
DB00374 | DB09030 | 1,061 | 840 | [
"DDInter1852",
"DDInter1945"
] | Treprostinil | Vorapaxar | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Moderate | 1 | [
[
[
1061,
24,
840
]
],
[
[
1061,
23,
944
],
[
944,
62,
840
]
],
[
[
1061,
24,
765
],
[
765,
24,
840
]
],
[
[
1061,
63,
529
],
[
529,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorapaxar"
]
],
[
[
"Treprostinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Treprostinil may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may caus... |
DB00877 | DB00881 | 629 | 954 | [
"DDInter1678",
"DDInter1554"
] | Sirolimus | Quinapril | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
629,
24,
954
]
],
[
[
629,
63,
1638
],
[
1638,
1,
954
]
],
[
[
629,
21,
28734
],
[
28734,
60,
954
]
],
[
[
629,
63,
251
],
[
251,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Sirolimus (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Quinapril (Compound)
Sirolimus may caus... |
DB00872 | DB12500 | 1,080 | 283 | [
"DDInter438",
"DDInter714"
] | Conivaptan | Fedratinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1080,
25,
283
]
],
[
[
1080,
24,
466
],
[
466,
62,
283
]
],
[
[
1080,
25,
351
],
[
351,
23,
283
]
],
[
[
1080,
63,
1419
],
[
1419,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daroluta... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Conivaptan may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may caus... |
DB00222 | DB00712 | 245 | 1,274 | [
"DDInter825",
"DDInter763"
] | Glimepiride | Flurbiprofen | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
245,
24,
1274
]
],
[
[
245,
24,
935
],
[
935,
63,
1274
]
],
[
[
245,
24,
1523
],
[
1523,
24,
1274
]
],
[
[
245,
6,
6017
],
[
6017,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Lab... |
DB01124 | DB08938 | 1,411 | 1,384 | [
"DDInter1828",
"DDInter1112"
] | Tolbutamide | Magaldrate | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1411,
24,
1384
]
],
[
[
1411,
63,
167
],
[
167,
23,
1384
]
],
[
[
1411,
62,
556
],
[
556,
23,
1384
]
],
[
[
1411,
24,
699
],
[
699,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Valproic acid a... |
DB00055 | DB01125 | 834 | 279 | [
"DDInter605",
"DDInter98"
] | Drotrecogin alfa | Anisindione | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Major | 2 | [
[
[
834,
25,
279
]
],
[
[
834,
24,
222
],
[
222,
24,
279
]
],
[
[
834,
24,
1074
],
[
1074,
63,
279
]
],
[
[
834,
25,
578
],
[
578,
6... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Iodide... |
DB01149 | DB11581 | 851 | 1,456 | [
"DDInter1274",
"DDInter1926"
] | Nefazodone | Venetoclax | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
851,
25,
1456
]
],
[
[
851,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
851,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
851,
63,
86
],
[
86,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Nefazodone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Nefazodone may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interact... |
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