drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00218 | DB00552 | 1,176 | 1,238 | [
"DDInter1247",
"DDInter1425"
] | Moxifloxacin | Pentostatin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Minor | 0 | [
[
[
1176,
23,
1238
]
],
[
[
1176,
21,
28769
],
[
28769,
60,
1238
]
],
[
[
1176,
1,
1467
],
[
1467,
23,
1238
]
],
[
[
1176,
1,
1539
],
[
15... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pentostatin"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u} (Sid... | Moxifloxacin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Pentostatin (Compound)
Moxifloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Pentostatin
Moxifloxacin (Compound) resemb... |
DB01218 | DB09083 | 1,493 | 880 | [
"DDInter852",
"DDInter996"
] | Halofantrine | Ivabradine | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
1493,
25,
880
]
],
[
[
1493,
63,
480
],
[
480,
24,
880
]
],
[
[
1493,
25,
1478
],
[
1478,
24,
880
]
],
[
[
1493,
25,
159
],
[
159,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formot... | Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Halofantrine may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may caus... |
DB00279 | DB01278 | 1,152 | 1,021 | [
"DDInter1074",
"DDInter1506"
] | Liothyronine | Pramlintide | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1152,
24,
1021
]
],
[
[
1152,
24,
380
],
[
380,
24,
1021
]
],
[
[
1152,
24,
35
],
[
35,
63,
1021
]
],
[
[
1152,
1,
542
],
[
542,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conjugated estrogens"
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00279 | DB00841 | 1,152 | 532 | [
"DDInter1074",
"DDInter577"
] | Liothyronine | Dobutamine | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Moderate | 1 | [
[
[
1152,
24,
532
]
],
[
[
1152,
24,
817
],
[
817,
40,
532
]
],
[
[
1152,
23,
1523
],
[
1523,
40,
532
]
],
[
[
1152,
21,
28775
],
[
28775,... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
[
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Dobutamine (Compound)
Liothyronine may cause a minor interaction that can limit clinical effects when taken with Labetalol and Labetalol (Compound) resembles Dobutamine (Compound)
Liot... |
DB00851 | DB09054 | 611 | 384 | [
"DDInter463",
"DDInter905"
] | Dacarbazine | Idelalisib | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
611,
24,
384
]
],
[
[
611,
24,
1627
],
[
1627,
62,
384
]
],
[
[
611,
24,
328
],
[
328,
24,
384
]
],
[
[
611,
63,
58
],
[
58,
24,... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and ... |
DB01075 | DB01244 | 1,376 | 762 | [
"DDInter569",
"DDInter192"
] | Diphenhydramine | Bepridil | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1376,
24,
762
]
],
[
[
1376,
74,
704
],
[
704,
1,
762
]
],
[
[
1376,
40,
11286
],
[
11286,
1,
762
]
],
[
[
1376,
1,
1661
],
[
1661,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when... | Diphenhydramine (Compound) resembles Fentanyl (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Bepridil (Compound)
Diphenhydramine (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) res... |
DB00550 | DB09420 | 99 | 1,074 | [
"DDInter1541",
"DDInter953"
] | Propylthiouracil | Iodide I-123 | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
99,
24,
1074
]
],
[
[
99,
24,
126
],
[
126,
24,
1074
]
],
[
[
99,
24,
126
],
[
126,
64,
161
],
[
161,
24,
1074
]
],
[
[
99,
6,
... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
... | Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin an... |
DB00773 | DB01320 | 896 | 651 | [
"DDInter702",
"DDInter783"
] | Etoposide | Fosphenytoin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
896,
24,
651
]
],
[
[
896,
62,
307
],
[
307,
1,
651
]
],
[
[
896,
63,
362
],
[
362,
1,
651
]
],
[
[
896,
6,
8374
],
[
8374,
45,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Etoposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Etoposide may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Etop... |
DB01253 | DB06764 | 628 | 1,090 | [
"DDInter664",
"DDInter1787"
] | Ergometrine | Tetryzoline (nasal) | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Major | 2 | [
[
[
628,
25,
1090
]
],
[
[
628,
1,
588
],
[
588,
25,
1090
]
],
[
[
628,
1,
588
],
[
588,
1,
1131
],
[
1131,
25,
1090
]
],
[
[
628,
1... | [
[
[
"Ergometrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetryzoline"
]
],
[
[
"Ergometrine",
"{u} (Compound) resembles {v} (Compound)",
"Methylergometrine"
],
[
"Methylergometrine",
"{u} may lead to a maj... | Ergometrine may lead to a major life threatening interaction when taken with Tetryzoline
Ergometrine (Compound) resembles Methylergometrine (Compound) and Methylergometrine may lead to a major life threatening interaction when taken with Tetryzoline
Ergometrine (Compound) resembles Methylergometrine (Compound) and Meth... |
DB00877 | DB01197 | 629 | 1,603 | [
"DDInter1678",
"DDInter292"
] | Sirolimus | Captopril | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
629,
24,
1603
]
],
[
[
629,
63,
610
],
[
610,
1,
1603
]
],
[
[
629,
6,
4973
],
[
4973,
45,
1603
]
],
[
[
629,
7,
7972
],
[
7972,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Captopril (Compound)
Sirolimus (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upre... |
DB00307 | DB01115 | 1,101 | 336 | [
"DDInter202",
"DDInter1291"
] | Bexarotene | Nifedipine | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
1101,
24,
336
]
],
[
[
1101,
63,
1428
],
[
1428,
1,
336
]
],
[
[
1101,
24,
1081
],
[
1081,
40,
336
]
],
[
[
1101,
24,
376
],
[
376,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compound... |
DB08881 | DB11732 | 868 | 1,097 | [
"DDInter1925",
"DDInter1027"
] | Vemurafenib | Lasmiditan | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
868,
24,
1097
]
],
[
[
868,
64,
1181
],
[
1181,
24,
1097
]
],
[
[
868,
25,
971
],
[
971,
63,
1097
]
],
[
[
868,
63,
1413
],
[
1413,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Terfenadine"
],
[
"Terfena... | Vemurafenib may lead to a major life threatening interaction when taken with Terfenadine and Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Vemurafenib may lead to a major life threatening interaction when taken with Gilteritinib and Gilteritinib may cause a moder... |
DB01394 | DB08881 | 1,554 | 868 | [
"DDInter431",
"DDInter1925"
] | Colchicine | Vemurafenib | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1554,
25,
868
]
],
[
[
1554,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1554,
18,
8386
],
[
8386,
46,
868
]
],
[
[
1554,
7,
6952
],
[
6952,
... | [
[
[
"Colchicine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Colchicine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Colchicine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Colchicine (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Vemurafenib (Compound)
Colchicine (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Vemurafenib (Compound)
Colchicin... |
DB00581 | DB01144 | 355 | 1,326 | [
"DDInter1018",
"DDInter540"
] | Lactulose | Diclofenamide | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Moderate | 1 | [
[
[
355,
24,
1326
]
],
[
[
355,
24,
504
],
[
504,
1,
1326
]
],
[
[
355,
24,
359
],
[
359,
40,
1326
]
],
[
[
355,
21,
28709
],
[
28709,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resem... |
DB00962 | DB01075 | 1,639 | 1,376 | [
"DDInter1957",
"DDInter569"
] | Zaleplon | Diphenhydramine | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1639,
24,
1376
]
],
[
[
1639,
24,
649
],
[
649,
63,
1376
]
],
[
[
1639,
63,
128
],
[
128,
24,
1376
]
],
[
[
1639,
24,
401
],
[
401,
... | [
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine a... |
DB00964 | DB01075 | 1,617 | 1,376 | [
"DDInter110",
"DDInter569"
] | Apraclonidine | Diphenhydramine | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1617,
24,
1376
]
],
[
[
1617,
24,
649
],
[
649,
63,
1376
]
],
[
[
1617,
63,
128
],
[
128,
24,
1376
]
],
[
[
1617,
24,
401
],
[
401,
... | [
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphe... |
DB00470 | DB01359 | 530 | 729 | [
"DDInter601",
"DDInter1417"
] | Dronabinol | Penbutolol | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
530,
24,
729
]
],
[
[
530,
63,
461
],
[
461,
1,
729
]
],
[
[
530,
24,
699
],
[
699,
40,
729
]
],
[
[
530,
21,
28762
],
[
28762,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Dronabinol (... |
DB09330 | DB12010 | 985 | 214 | [
"DDInter1352",
"DDInter785"
] | Osimertinib | Fostamatinib | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
985,
24,
214
]
],
[
[
985,
64,
976
],
[
976,
24,
214
]
],
[
[
985,
63,
723
],
[
723,
24,
214
]
],
[
[
985,
24,
861
],
[
861,
63,... | [
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofac... | Osimertinib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ... |
DB00675 | DB01165 | 888 | 1,539 | [
"DDInter1744",
"DDInter1325"
] | Tamoxifen | Ofloxacin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
888,
24,
1539
]
],
[
[
888,
64,
1176
],
[
1176,
1,
1539
]
],
[
[
888,
25,
945
],
[
945,
40,
1539
]
],
[
[
888,
24,
956
],
[
956,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxaci... | Tamoxifen may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Tamoxifen may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Tamoxifen may cause a mode... |
DB01050 | DB08827 | 848 | 990 | [
"DDInter900",
"DDInter1085"
] | Ibuprofen | Lomitapide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
848,
25,
990
]
],
[
[
848,
6,
4973
],
[
4973,
45,
990
]
],
[
[
848,
21,
28701
],
[
28701,
60,
990
]
],
[
[
848,
25,
1409
],
[
1409,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Ibuprofen",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lomitapide"... | Ibuprofen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lomitapide (Compound)
Ibuprofen (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Lomitapide (Compound)
Ibuprofen may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a mod... |
DB08815 | DB12500 | 154 | 283 | [
"DDInter1104",
"DDInter714"
] | Lurasidone | Fedratinib | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
154,
25,
283
]
],
[
[
154,
24,
466
],
[
466,
62,
283
]
],
[
[
154,
25,
351
],
[
351,
23,
283
]
],
[
[
154,
64,
1419
],
[
1419,
2... | [
[
[
"Lurasidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daroluta... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Lurasidone may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may caus... |
DB00938 | DB01267 | 455 | 519 | [
"DDInter1635",
"DDInter1381"
] | Salmeterol | Paliperidone | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
455,
24,
519
]
],
[
[
455,
63,
1664
],
[
1664,
1,
519
]
],
[
[
455,
24,
924
],
[
924,
1,
519
]
],
[
[
455,
6,
7524
],
[
7524,
45... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Co... |
DB00963 | DB01088 | 1,263 | 714 | [
"DDInter241",
"DDInter908"
] | Bromfenac | Iloprost | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1263,
24,
714
]
],
[
[
1263,
63,
1479
],
[
1479,
24,
714
]
],
[
[
1263,
1,
24
],
[
24,
24,
714
]
],
[
[
1263,
24,
1564
],
[
1564,
... | [
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Bromfenac (Compound) resembles Tolmetin (Compound) and Tolmetin may cause a moderate interactio... |
DB01033 | DB01165 | 328 | 1,539 | [
"DDInter1156",
"DDInter1325"
] | Mercaptopurine | Ofloxacin | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
328,
23,
1539
]
],
[
[
328,
62,
1467
],
[
1467,
1,
1539
]
],
[
[
328,
23,
945
],
[
945,
40,
1539
]
],
[
[
328,
23,
246
],
[
246,
... | [
[
[
"Mercaptopurine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Mercaptopurine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
... | Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound... |
DB00069 | DB00563 | 367 | 663 | [
"DDInter946",
"DDInter1174"
] | Interferon alfacon-1 | Methotrexate | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
367,
24,
663
]
],
[
[
367,
24,
126
],
[
126,
62,
663
]
],
[
[
367,
24,
738
],
[
738,
63,
663
]
],
[
[
367,
64,
1648
],
[
1648,
2... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfa... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Nirap... |
DB00205 | DB00795 | 929 | 50 | [
"DDInter1550",
"DDInter1725"
] | Pyrimethamine | Sulfasalazine | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
929,
24,
50
]
],
[
[
929,
24,
161
],
[
161,
1,
50
]
],
[
[
929,
7,
2067
],
[
2067,
45,
50
]
],
[
[
929,
18,
6929
],
[
6929,
57,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
... | Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Pyrimethamine (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is bound by Sulfasalazine (Compound)
Pyrimethamine (Compound) downregulates ITGAE (... |
DB00023 | DB00627 | 305 | 265 | [
"DDInter127",
"DDInter1286"
] | Asparaginase Escherichia coli | Niacin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
305,
24,
265
]
],
[
[
305,
24,
1479
],
[
1479,
62,
265
]
],
[
[
305,
24,
245
],
[
245,
24,
265
]
],
[
[
305,
24,
1296
],
[
1296,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Niacin
Asparaginase Escherichia coli may cause a moderate interaction that could exace... |
DB01024 | DB01598 | 1,096 | 483 | [
"DDInter1252",
"DDInter911"
] | Mycophenolic acid | Imipenem | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include [meropenem], known for having greater activity ... | Moderate | 1 | [
[
[
1096,
24,
483
]
],
[
[
1096,
18,
1917
],
[
1917,
57,
483
]
],
[
[
1096,
62,
1031
],
[
1031,
24,
483
]
],
[
[
1096,
63,
164
],
[
164,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imipenem"
]
],
[
[
"Mycophenolic acid",
"{u} (Compound) downregulates {v} (Gene)",
"CDC25B"
],
[
"CDC25B",
"{u} (Gene) is downr... | Mycophenolic acid (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Imipenem (Compound)
Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with... |
DB06674 | DB11793 | 908 | 738 | [
"DDInter837",
"DDInter1297"
] | Golimumab | Niraparib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Major | 2 | [
[
[
908,
25,
738
]
],
[
[
908,
64,
1213
],
[
1213,
24,
738
]
],
[
[
908,
24,
496
],
[
496,
24,
738
]
],
[
[
908,
63,
759
],
[
759,
2... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Niraparib"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
"{u} may ca... | Golimumab may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vacci... |
DB00254 | DB14761 | 964 | 242 | [
"DDInter598",
"DDInter1578"
] | Doxycycline | Remdesivir | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
964,
24,
242
]
],
[
[
964,
24,
384
],
[
384,
24,
242
]
],
[
[
964,
25,
1517
],
[
1517,
24,
242
]
],
[
[
964,
63,
1560
],
[
1560,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Doxycycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may ... |
DB00906 | DB12130 | 1,567 | 1,017 | [
"DDInter1801",
"DDInter1094"
] | Tiagabine | Lorlatinib | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1567,
24,
1017
]
],
[
[
1567,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
1567,
63,
629
],
[
629,
24,
1017
]
],
[
[
1567,
24,
214
],
[
214,
... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus m... |
DB00983 | DB05812 | 480 | 1,374 | [
"DDInter776",
"DDInter8"
] | Formoterol | Abiraterone | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
480,
24,
1374
]
],
[
[
480,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
480,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
480,
63,
1028
],
[
102... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Formoterol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Formoterol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Formoterol (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Torasemide ... |
DB00238 | DB00563 | 188 | 663 | [
"DDInter1285",
"DDInter1174"
] | Nevirapine | Methotrexate | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
188,
24,
663
]
],
[
[
188,
21,
28681
],
[
28681,
60,
663
]
],
[
[
188,
24,
126
],
[
126,
62,
663
]
],
[
[
188,
24,
594
],
[
594,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Nevirapine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side... | Nevirapine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken wi... |
DB05316 | DB13074 | 749 | 877 | [
"DDInter1467",
"DDInter1110"
] | Pimavanserin | Macimorelin | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
749,
25,
877
]
],
[
[
749,
62,
112
],
[
112,
23,
877
]
],
[
[
749,
24,
1320
],
[
1320,
24,
877
]
],
[
[
749,
63,
1101
],
[
1101,
... | [
[
[
"Pimavanserin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and E... |
DB00467 | DB04272 | 1,467 | 442 | [
"DDInter644",
"DDInter390"
] | Enoxacin | Citric acid | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020. ... | Moderate | 1 | [
[
[
1467,
24,
442
]
],
[
[
1467,
40,
1176
],
[
1176,
24,
442
]
],
[
[
1467,
1,
956
],
[
956,
24,
442
]
],
[
[
1467,
24,
115
],
[
115,
... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citric acid"
]
],
[
[
"Enoxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause a modera... | Enoxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Citric acid
Enoxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Citric a... |
DB01285 | DB11988 | 708 | 270 | [
"DDInter445",
"DDInter1321"
] | Corticotropin | Ocrelizumab | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
708,
24,
270
]
],
[
[
708,
24,
713
],
[
713,
24,
270
]
],
[
[
708,
24,
287
],
[
287,
63,
270
]
],
[
[
708,
63,
66
],
[
66,
24,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00853 | DB05528 | 1,686 | 1,070 | [
"DDInter1762",
"DDInter1228"
] | Temozolomide | Mipomersen | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1686,
25,
1070
]
],
[
[
1686,
64,
581
],
[
581,
25,
1070
]
],
[
[
1686,
63,
1555
],
[
1555,
25,
1070
]
],
[
[
1686,
24,
384
],
[
384,
... | [
[
[
"Temozolomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Temozolomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
"Infliximab",
"{... | Temozolomide may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Mipomersen
Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may lead to a major... |
DB01067 | DB01611 | 959 | 1,487 | [
"DDInter826",
"DDInter893"
] | Glipizide | Hydroxychloroquine | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
959,
24,
1487
]
],
[
[
959,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
959,
63,
1247
],
[
1247,
23,
1487
]
],
[
[
959,
63,
723
],
[
723,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Glipizide",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is ... | Glipizide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when take... |
DB00059 | DB01149 | 1,560 | 851 | [
"DDInter1404",
"DDInter1274"
] | Pegaspargase | Nefazodone | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
1560,
24,
851
]
],
[
[
1560,
25,
1101
],
[
1101,
23,
851
]
],
[
[
1560,
24,
1374
],
[
1374,
62,
851
]
],
[
[
1560,
24,
1130
],
[
1130,... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Pegaspargase may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Nefazodone
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may ca... |
DB01261 | DB06016 | 170 | 1,508 | [
"DDInter1679",
"DDInter300"
] | Sitagliptin | Cariprazine | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
170,
24,
1508
]
],
[
[
170,
63,
176
],
[
176,
24,
1508
]
],
[
[
170,
24,
913
],
[
913,
63,
1508
]
],
[
[
170,
64,
1101
],
[
1101,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
],... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Apalut... |
DB00019 | DB13007 | 1,257 | 1,060 | [
"DDInter1405",
"DDInter642"
] | Pegfilgrastim | Enfortumab vedotin | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1257,
24,
1060
]
],
[
[
1257,
24,
350
],
[
350,
24,
1060
]
],
[
[
1257,
63,
491
],
[
491,
24,
1060
]
],
[
[
1257,
25,
1064
],
[
1064,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Pegin... |
DB00317 | DB01319 | 883 | 34 | [
"DDInter810",
"DDInter777"
] | Gefitinib | Fosamprenavir | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
883,
24,
34
]
],
[
[
883,
24,
1091
],
[
1091,
40,
34
]
],
[
[
883,
6,
8374
],
[
8374,
45,
34
]
],
[
[
883,
21,
28723
],
[
28723,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Gefitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Gefitinib (Compound) causes Malnutrition (Side Effect) and Mal... |
DB01045 | DB09122 | 463 | 1,613 | [
"DDInter1590",
"DDInter1409"
] | Rifampicin | Peginterferon beta-1a | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
463,
24,
1613
]
],
[
[
463,
64,
600
],
[
600,
24,
1613
]
],
[
[
463,
63,
267
],
[
267,
24,
1613
]
],
[
[
463,
25,
263
],
[
263,
... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
... | Rifampicin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexo... |
DB00877 | DB00994 | 629 | 361 | [
"DDInter1678",
"DDInter1277"
] | Sirolimus | Neomycin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Major | 2 | [
[
[
629,
25,
361
]
],
[
[
629,
63,
1647
],
[
1647,
24,
361
]
],
[
[
629,
21,
28722
],
[
28722,
60,
361
]
],
[
[
629,
63,
608
],
[
608,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
"Acarbose",
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Sirolimus (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Sirolimus ma... |
DB00747 | DB01409 | 1,442 | 1,415 | [
"DDInter1647",
"DDInter1815"
] | Scopolamine | Tiotropium | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1442,
24,
1415
]
],
[
[
1442,
1,
11336
],
[
11336,
40,
1415
]
],
[
[
1442,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
1442,
21,
28680
],
[
2... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Scopolamine",
"{u} (Compound) resembles {v} (Compound)",
"Methylscopolamine bromide"
],
[
"Methylscopolamine bromide"... | Scopolamine (Compound) resembles Methylscopolamine bromide (Compound) and Methylscopolamine bromide (Compound) resembles Tiotropium (Compound)
Scopolamine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Scopolamine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by... |
DB00427 | DB01246 | 1,233 | 820 | [
"DDInter1879",
"DDInter45"
] | Triprolidine | Alimemazine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1233,
24,
820
]
],
[
[
1233,
24,
358
],
[
358,
24,
820
]
],
[
[
1233,
24,
104
],
[
104,
40,
820
]
],
[
[
1233,
24,
649
],
[
649,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine... |
DB08868 | DB10429 | 1,011 | 200 | [
"DDInter737",
"DDInter282"
] | Fingolimod | Candida albicans | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1011,
24,
200
]
],
[
[
1011,
64,
1096
],
[
1096,
24,
200
]
],
[
[
1011,
25,
976
],
[
976,
24,
200
]
],
[
[
1011,
25,
1019
],
[
1019,
... | [
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
],
[
... | Fingolimod may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Fingolimod may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may... |
DB00279 | DB13142 | 1,152 | 841 | [
"DDInter1074",
"DDInter274"
] | Liothyronine | Calcium glubionate anhydrous | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
1152,
24,
841
]
],
[
[
1152,
24,
1436
],
[
1436,
24,
841
]
],
[
[
1152,
1,
624
],
[
624,
24,
841
]
],
[
[
1152,
23,
887
],
[
887,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patir... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Patiromer and Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Liothyronine (Compound) resembles Liotrix (Compound) and Liotrix may cause a moderate interact... |
DB06168 | DB09036 | 1,531 | 812 | [
"DDInter281",
"DDInter1668"
] | Canakinumab | Siltuximab | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
1531,
24,
812
]
],
[
[
1531,
23,
1193
],
[
1193,
62,
812
]
],
[
[
1531,
62,
1461
],
[
1461,
23,
812
]
],
[
[
1531,
24,
287
],
[
287,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Canakinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
... | Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Siltuximab
Canakinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vit... |
DB00348 | DB09118 | 254 | 1,580 | [
"DDInter1300",
"DDInter1711"
] | Nitisinone | Stiripentol | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
254,
24,
1580
]
],
[
[
254,
24,
283
],
[
283,
63,
1580
]
],
[
[
254,
63,
1018
],
[
1018,
24,
1580
]
],
[
[
254,
24,
98
],
[
98,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticl... |
DB00023 | DB00196 | 305 | 600 | [
"DDInter127",
"DDInter743"
] | Asparaginase Escherichia coli | Fluconazole | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Moderate | 1 | [
[
[
305,
24,
600
]
],
[
[
305,
24,
609
],
[
609,
62,
600
]
],
[
[
305,
25,
1101
],
[
1101,
62,
600
]
],
[
[
305,
24,
1613
],
[
1613,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Asparaginase Escherichia coli may lead to a major life threatening interaction when ta... |
DB00366 | DB06691 | 1,594 | 849 | [
"DDInter600",
"DDInter1155"
] | Doxylamine | Mepyramine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1594,
24,
849
]
],
[
[
1594,
1,
11775
],
[
11775,
40,
849
]
],
[
[
1594,
40,
11244
],
[
11244,
1,
849
]
],
[
[
1594,
35,
272
],
[
272,... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Doxylamine",
"{u} (Compound) resembles {v} (Compound)",
"Chloropyramine"
],
[
"Chloropyramine",
"{u} (Compound) ... | Doxylamine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Doxylamine (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Mepyramine (Compound)
Doxylamine (Compound) resembles Chlorpheniramine (Compound) and Doxylamine may cause a... |
DB00439 | DB12500 | 289 | 283 | [
"DDInter341",
"DDInter714"
] | Cerivastatin | Fedratinib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
289,
24,
283
]
],
[
[
289,
24,
466
],
[
466,
62,
283
]
],
[
[
289,
24,
351
],
[
351,
23,
283
]
],
[
[
289,
24,
1419
],
[
1419,
2... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and ... |
DB00059 | DB09564 | 1,560 | 1,296 | [
"DDInter1404",
"DDInter930"
] | Pegaspargase | Insulin degludec | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1560,
24,
1296
]
],
[
[
1560,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1560,
24,
1385
],
[
1385,
63,
1296
]
],
[
[
1560,
25,
695
],
[
695... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Semagluti... |
DB00405 | DB00497 | 128 | 828 | [
"DDInter517",
"DDInter1366"
] | Dexbrompheniramine | Oxycodone | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
128,
24,
828
]
],
[
[
128,
63,
421
],
[
421,
1,
828
]
],
[
[
128,
24,
314
],
[
314,
1,
828
]
],
[
[
128,
24,
560
],
[
560,
40,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphon... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Oxycodone (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles O... |
DB06448 | DB08816 | 171 | 578 | [
"DDInter1087",
"DDInter1802"
] | Lonafarnib | Ticagrelor | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
171,
25,
578
]
],
[
[
171,
25,
1135
],
[
1135,
62,
578
]
],
[
[
171,
64,
723
],
[
723,
24,
578
]
],
[
[
171,
24,
868
],
[
868,
6... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Lonafarnib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Lonafarnib may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate interact... |
DB01098 | DB08938 | 14 | 1,384 | [
"DDInter1622",
"DDInter1112"
] | Rosuvastatin | Magaldrate | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
14,
24,
1384
]
],
[
[
14,
24,
1191
],
[
1191,
23,
1384
]
],
[
[
14,
63,
954
],
[
954,
23,
1384
]
],
[
[
14,
24,
72
],
[
72,
24,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
],
[
... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodopa may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril... |
DB06335 | DB15093 | 761 | 1,654 | [
"DDInter1646",
"DDInter1698"
] | Saxagliptin | Somapacitan | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
761,
24,
1654
]
],
[
[
761,
63,
168
],
[
168,
23,
1654
]
],
[
[
761,
63,
176
],
[
176,
24,
1654
]
],
[
[
761,
24,
351
],
[
351,
... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and... |
DB00694 | DB11791 | 51 | 785 | [
"DDInter485",
"DDInter287"
] | Daunorubicin | Capmatinib | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
51,
24,
785
]
],
[
[
51,
25,
868
],
[
868,
24,
785
]
],
[
[
51,
63,
482
],
[
482,
24,
785
]
],
[
[
51,
74,
322
],
[
322,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemur... | Daunorubicin may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may ... |
DB00976 | DB12941 | 1,056 | 466 | [
"DDInter1758",
"DDInter481"
] | Telithromycin | Darolutamide | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1056,
24,
466
]
],
[
[
1056,
24,
1374
],
[
1374,
23,
466
]
],
[
[
1056,
63,
600
],
[
600,
23,
466
]
],
[
[
1056,
25,
351
],
[
351,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole a... |
DB00388 | DB00771 | 1,636 | 262 | [
"DDInter1453",
"DDInter397"
] | Phenylephrine | Clidinium | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
1636,
24,
262
]
],
[
[
1636,
24,
1511
],
[
1511,
63,
262
]
],
[
[
1636,
24,
1252
],
[
1252,
23,
262
]
],
[
[
1636,
24,
19
],
[
19,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Di... |
DB00241 | DB01229 | 288 | 973 | [
"DDInter257",
"DDInter1378"
] | Butalbital | Paclitaxel (protein-bound) | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
288,
24,
973
]
],
[
[
288,
24,
310
],
[
310,
63,
973
]
],
[
[
288,
24,
458
],
[
458,
24,
973
]
],
[
[
288,
23,
752
],
[
752,
24,... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Butalbit... |
DB00678 | DB00860 | 240 | 891 | [
"DDInter1095",
"DDInter1513"
] | Losartan | Prednisolone | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
240,
24,
891
]
],
[
[
240,
63,
175
],
[
175,
40,
891
]
],
[
[
240,
24,
167
],
[
167,
1,
891
]
],
[
[
240,
24,
617
],
[
617,
40,
... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Losartan may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Losartan may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Prednisolo... |
DB01618 | DB08897 | 776 | 1,429 | [
"DDInter1239",
"DDInter22"
] | Molindone | Aclidinium | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
776,
24,
1429
]
],
[
[
776,
63,
352
],
[
352,
24,
1429
]
],
[
[
776,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
776,
6,
7992
],
[
7992,
... | [
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Molindone may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Molindone may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate... |
DB09065 | DB14568 | 760 | 982 | [
"DDInter424",
"DDInter1000"
] | Cobicistat | Ivosidenib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
760,
25,
982
]
],
[
[
760,
62,
271
],
[
271,
23,
982
]
],
[
[
760,
63,
168
],
[
168,
23,
982
]
],
[
[
760,
64,
976
],
[
976,
24,... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Cobicistat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",... | Cobicistat may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib... |
DB00254 | DB00319 | 964 | 790 | [
"DDInter598",
"DDInter1474"
] | Doxycycline | Piperacillin | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. | Moderate | 1 | [
[
[
964,
24,
790
]
],
[
[
964,
24,
1366
],
[
1366,
1,
790
]
],
[
[
964,
24,
1681
],
[
1681,
40,
790
]
],
[
[
964,
6,
10612
],
[
10612,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piperacillin"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meticillin"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Meticillin and Meticillin (Compound) resembles Piperacillin (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Mezlocillin and Mezlocillin (Compound) resembles Piperacillin (Co... |
DB00543 | DB05294 | 87 | 1,069 | [
"DDInter82",
"DDInter1917"
] | Amoxapine | Vandetanib | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
87,
25,
1069
]
],
[
[
87,
6,
6943
],
[
6943,
45,
1069
]
],
[
[
87,
21,
28921
],
[
28921,
60,
1069
]
],
[
[
87,
23,
112
],
[
112,
... | [
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Amoxapine",
"{u} (Compound) binds {v} (Gene)",
"ORM1"
],
[
"ORM1",
"{u} (Gene) is bound by {v} (Compound)",
"Vandetanib"
... | Amoxapine (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Vandetanib (Compound)
Amoxapine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Vandetanib (Compound)
Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidaz... |
DB09039 | DB09128 | 1,670 | 1,241 | [
"DDInter629",
"DDInter231"
] | Eliglustat | Brexpiprazole | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Major | 2 | [
[
[
1670,
25,
1241
]
],
[
[
1670,
64,
129
],
[
129,
24,
1241
]
],
[
[
1670,
25,
741
],
[
741,
63,
1241
]
],
[
[
1670,
63,
543
],
[
543,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Eliglustat may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Eliglustat may lead to a major life threatening interaction when taken with Rolapitant and Rolapitant may cause a modera... |
DB00812 | DB11793 | 998 | 738 | [
"DDInter1451",
"DDInter1297"
] | Phenylbutazone | Niraparib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
998,
24,
738
]
],
[
[
998,
24,
466
],
[
466,
63,
738
]
],
[
[
998,
25,
1213
],
[
1213,
24,
738
]
],
[
[
998,
64,
663
],
[
663,
2... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Phenylbutazone may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib m... |
DB11730 | DB15035 | 351 | 503 | [
"DDInter1588",
"DDInter1959"
] | Ribociclib | Zanubrutinib | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
351,
25,
503
]
],
[
[
351,
63,
1094
],
[
1094,
24,
503
]
],
[
[
351,
25,
982
],
[
982,
24,
503
]
],
[
[
351,
64,
868
],
[
868,
2... | [
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
"Metrele... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Ribociclib may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may ca... |
DB00331 | DB01035 | 1,645 | 1,401 | [
"DDInter1164",
"DDInter1524"
] | Metformin | Procainamide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A derivative of procaine with less CNS action. | Moderate | 1 | [
[
[
1645,
24,
1401
]
],
[
[
1645,
6,
10659
],
[
10659,
45,
1401
]
],
[
[
1645,
21,
28658
],
[
28658,
60,
1401
]
],
[
[
1645,
24,
659
],
[
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procainamide"
]
],
[
[
"Metformin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A3"
],
[
"SLC22A3",
"{u} (Gene) is bound by {v} (Compound)... | Metformin (Compound) binds SLC22A3 (Gene) and SLC22A3 (Gene) is bound by Procainamide (Compound)
Metformin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Procainamide (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vil... |
DB01396 | DB01575 | 1,482 | 1,054 | [
"DDInter553",
"DDInter1005"
] | Digitoxin | Kaolin | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1482,
24,
1054
]
],
[
[
1482,
63,
964
],
[
964,
24,
1054
]
],
[
[
1482,
40,
1252
],
[
1252,
24,
1054
]
],
[
[
1482,
63,
964
],
[
964,
... | [
[
[
"Digitoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Digitoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
],
[
"... | Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Digitoxin (Compound) resembles Digoxin (Compound) and Digoxin may cause a moderate interaction that could exacerbat... |
DB00489 | DB09104 | 17 | 286 | [
"DDInter1704",
"DDInter1118"
] | Sotalol | Magnesium hydroxide | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
17,
24,
286
]
],
[
[
17,
25,
820
],
[
820,
23,
286
]
],
[
[
17,
1,
88
],
[
88,
23,
286
]
],
[
[
17,
24,
104
],
[
104,
23,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
"Alimem... | Sotalol may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Sotalol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a minor interaction that can limit clinical e... |
DB00218 | DB00836 | 1,176 | 543 | [
"DDInter1247",
"DDInter1088"
] | Moxifloxacin | Loperamide | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
1176,
24,
543
]
],
[
[
1176,
25,
888
],
[
888,
24,
543
]
],
[
[
1176,
21,
28722
],
[
28722,
60,
543
]
],
[
[
1176,
25,
982
],
[
982,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamoxif... | Moxifloxacin may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Moxifloxacin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loperamide (Compound)
Moxifloxacin ma... |
DB01261 | DB04865 | 170 | 4 | [
"DDInter1679",
"DDInter1335"
] | Sitagliptin | Omacetaxine mepesuccinate | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
170,
24,
4
]
],
[
[
170,
18,
18560
],
[
18560,
57,
4
]
],
[
[
170,
63,
485
],
[
485,
24,
4
]
],
[
[
170,
24,
1616
],
[
1616,
63,... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Sitagliptin",
"{u} (Compound) downregulates {v} (Gene)",
"PSRC1"
],
[
"PSRC1",
"{u} (Gene) is do... | Sitagliptin (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00060 | DB00330 | 912 | 238 | [
"DDInter947",
"DDInter689"
] | Interferon beta-1a | Ethambutol | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Moderate | 1 | [
[
[
912,
24,
238
]
],
[
[
912,
24,
467
],
[
467,
63,
238
]
],
[
[
912,
63,
1451
],
[
1451,
24,
238
]
],
[
[
912,
24,
168
],
[
168,
2... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethambutol"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Int... |
DB09082 | DB09330 | 659 | 985 | [
"DDInter1934",
"DDInter1352"
] | Vilanterol | Osimertinib | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
659,
24,
985
]
],
[
[
659,
63,
480
],
[
480,
24,
985
]
],
[
[
659,
24,
1032
],
[
1032,
63,
985
]
],
[
[
659,
62,
1220
],
[
1220,
... | [
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and L... |
DB00996 | DB01075 | 1,198 | 1,376 | [
"DDInter791",
"DDInter569"
] | Gabapentin | Diphenhydramine | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1198,
24,
1376
]
],
[
[
1198,
24,
649
],
[
649,
63,
1376
]
],
[
[
1198,
63,
128
],
[
128,
24,
1376
]
],
[
[
1198,
24,
401
],
[
401,
... | [
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphenirami... |
DB00408 | DB09488 | 1,408 | 103 | [
"DDInter1099",
"DDInter23"
] | Loxapine | Acrivastine | An antipsychotic agent used in schizophrenia. [PubChem] | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1408,
24,
103
]
],
[
[
1408,
24,
85
],
[
85,
24,
103
]
],
[
[
1408,
35,
537
],
[
537,
24,
103
]
],
[
[
1408,
1,
87
],
[
87,
24,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[
"... | Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Loxapine (Compound) resembles Cyclizine (Compound) and Loxapine may cause a moderate interaction that could exacerbat... |
DB09481 | DB14006 | 460 | 972 | [
"DDInter1113",
"DDInter370"
] | Magnesium carbonate | Choline salicylate | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
460,
24,
972
]
],
[
[
460,
63,
286
],
[
286,
24,
972
]
],
[
[
460,
63,
286
],
[
286,
63,
1573
],
[
1573,
24,
972
]
],
[
[
460,
6... | [
[
[
"Magnesium carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Magnesium carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"M... | Magnesium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Magnesium carbonate may cause a moderate interaction that could exacerbate di... |
DB00532 | DB09036 | 208 | 812 | [
"DDInter1152",
"DDInter1668"
] | Mephenytoin | Siltuximab | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
208,
24,
812
]
],
[
[
208,
63,
1031
],
[
1031,
24,
812
]
],
[
[
208,
62,
608
],
[
608,
24,
812
]
],
[
[
208,
24,
147
],
[
147,
2... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Mephenytoin may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lid... |
DB09098 | DB11703 | 98 | 405 | [
"DDInter1700",
"DDInter9"
] | Somatrem | Acalabrutinib | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
98,
24,
405
]
],
[
[
98,
63,
690
],
[
690,
24,
405
]
],
[
[
98,
64,
1101
],
[
1101,
24,
405
]
],
[
[
98,
24,
1598
],
[
1598,
63,... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Somatrem may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a m... |
DB06288 | DB06589 | 607 | 1,250 | [
"DDInter77",
"DDInter1400"
] | Amisulpride | Pazopanib | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
607,
25,
1250
]
],
[
[
607,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
607,
62,
112
],
[
112,
23,
1250
]
],
[
[
607,
64,
1151
],
[
1151,
... | [
[
[
"Amisulpride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Amisulpride",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {v} (Compo... | Amisulpride (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Amisulpride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopa... |
DB00519 | DB00761 | 1,638 | 1,621 | [
"DDInter1843",
"DDInter1497"
] | Trandolapril | Potassium chloride | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
1638,
25,
1621
]
],
[
[
1638,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
1638,
63,
1685
],
[
1685,
23,
1621
]
],
[
[
1638,
24,
1254
],
[
... | [
[
[
"Trandolapril",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Trandolapril",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused ... | Trandolapril (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a minor interaction that can limit clinical effects when ta... |
DB00924 | DB08880 | 1,405 | 1,510 | [
"DDInter454",
"DDInter1771"
] | Cyclobenzaprine | Teriflunomide | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
1405,
24,
1510
]
],
[
[
1405,
24,
985
],
[
985,
64,
1510
]
],
[
[
1405,
25,
593
],
[
593,
25,
1510
]
],
[
[
1405,
63,
1648
],
[
1648,
... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
... | Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimertinib may lead to a major life threatening interaction when taken with Teriflunomide
Cyclobenzaprine may lead to a major life threatening interaction when taken with Bupropion and Bupropion may lead to ... |
DB01169 | DB01232 | 57 | 1,327 | [
"DDInter120",
"DDInter1640"
] | Arsenic trioxide | Saquinavir | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
57,
25,
1327
]
],
[
[
57,
25,
833
],
[
833,
1,
1327
]
],
[
[
57,
6,
8374
],
[
8374,
45,
1327
]
],
[
[
57,
62,
112
],
[
112,
23,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lopinavir"
],
[
"Lopinavir",
... | Arsenic trioxide may lead to a major life threatening interaction when taken with Lopinavir and Lopinavir (Compound) resembles Saquinavir (Compound)
Arsenic trioxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saquinavir (Compound)
Arsenic trioxide may cause a minor interaction that can limit clinical ... |
DB01144 | DB09135 | 1,326 | 1,211 | [
"DDInter540",
"DDInter967"
] | Diclofenamide | Ioxilan | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
1326,
24,
1211
]
],
[
[
1326,
1,
674
],
[
674,
24,
1211
]
],
[
[
1326,
63,
1648
],
[
1648,
24,
1211
]
],
[
[
1326,
40,
504
],
[
504,
... | [
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Diclofenamide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiazide",
"{u} ... | Diclofenamide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate i... |
DB00582 | DB11837 | 1,622 | 1,297 | [
"DDInter1946",
"DDInter1351"
] | Voriconazole | Osilodrostat | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1622,
25,
1297
]
],
[
[
1622,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
1622,
23,
112
],
[
112,
23,
1297
]
],
[
[
1622,
23,
466
],
[
466,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{... | Voriconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may ... |
DB01095 | DB06210 | 671 | 72 | [
"DDInter769",
"DDInter631"
] | Fluvastatin | Eltrombopag | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
671,
24,
72
]
],
[
[
671,
6,
3486
],
[
3486,
45,
72
]
],
[
[
671,
24,
384
],
[
384,
63,
72
]
],
[
[
671,
63,
467
],
[
467,
24,
... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Fluvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Fluvastatin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Eltrombopag (Compound)
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Fluvastatin ma... |
DB06626 | DB08880 | 263 | 1,510 | [
"DDInter147",
"DDInter1771"
] | Axitinib | Teriflunomide | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
263,
25,
1510
]
],
[
[
263,
25,
129
],
[
129,
63,
1510
]
],
[
[
263,
24,
242
],
[
242,
63,
1510
]
],
[
[
263,
64,
697
],
[
697,
... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
"{u... | Axitinib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cau... |
DB00350 | DB00741 | 1,214 | 167 | [
"DDInter1226",
"DDInter885"
] | Minoxidil | Hydrocortisone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1214,
24,
167
]
],
[
[
1214,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1214,
24,
870
],
[
870,
1,
167
]
],
[
[
1214,
24,
1364
],
[
1364,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydr... |
DB00630 | DB00863 | 1,485 | 1,194 | [
"DDInter42",
"DDInter1568"
] | Alendronic acid | Ranitidine | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Minor | 0 | [
[
[
1485,
23,
1194
]
],
[
[
1485,
62,
1127
],
[
1127,
1,
1194
]
],
[
[
1485,
21,
28701
],
[
28701,
60,
1194
]
],
[
[
1485,
24,
115
],
[
11... | [
[
[
"Alendronic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
]
],
[
[
"Alendronic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
],
... | Alendronic acid may cause a minor interaction that can limit clinical effects when taken with Nizatidine and Nizatidine (Compound) resembles Ranitidine (Compound)
Alendronic acid (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Ranitidine (Compound)
Alendronic acid may cause a modera... |
DB06589 | DB10276 | 1,250 | 1,624 | [
"DDInter1400",
"DDInter1623"
] | Pazopanib | Rotavirus vaccine | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1250,
25,
1624
]
],
[
[
1250,
63,
617
],
[
617,
24,
1624
]
],
[
[
1250,
64,
770
],
[
770,
25,
1624
]
],
[
[
1250,
63,
51
],
[
51,
... | [
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
[
"Budes... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Pazopanib may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may... |
DB01182 | DB09020 | 371 | 28 | [
"DDInter1534",
"DDInter212"
] | Propafenone | Bisacodyl | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
371,
24,
28
]
],
[
[
371,
18,
4884
],
[
4884,
57,
28
]
],
[
[
371,
21,
28666
],
[
28666,
60,
28
]
],
[
[
371,
24,
823
],
[
823,
... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Propafenone",
"{u} (Compound) downregulates {v} (Gene)",
"POLR2I"
],
[
"POLR2I",
"{u} (Gene) is downregulated by... | Propafenone (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Bisacodyl (Compound)
Propafenone (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Propafenone may cause a moderate interaction that could exacerbate... |
DB00438 | DB00446 | 149 | 597 | [
"DDInter330",
"DDInter351"
] | Ceftazidime | Chloramphenicol | Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of esse... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
149,
24,
597
]
],
[
[
149,
6,
10612
],
[
10612,
45,
597
]
],
[
[
149,
21,
29081
],
[
29081,
60,
597
]
],
[
[
149,
24,
450
],
[
450,
... | [
[
[
"Ceftazidime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Ceftazidime",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Co... | Ceftazidime (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Chloramphenicol (Compound)
Ceftazidime (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Chloramphenicol (Compound)
Ceftazidime may cause a moderate interaction that could exacerbate diseases when taken with Cy... |
DB08881 | DB14568 | 868 | 982 | [
"DDInter1925",
"DDInter1000"
] | Vemurafenib | Ivosidenib | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
868,
25,
982
]
],
[
[
868,
23,
271
],
[
271,
23,
982
]
],
[
[
868,
62,
112
],
[
112,
23,
982
]
],
[
[
868,
63,
1101
],
[
1101,
2... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metroni... |
DB00939 | DB09122 | 1,338 | 1,613 | [
"DDInter1135",
"DDInter1409"
] | Meclofenamic acid | Peginterferon beta-1a | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1338,
24,
1613
]
],
[
[
1338,
63,
1274
],
[
1274,
24,
1613
]
],
[
[
1338,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
1338,
25,
292
],
[
292... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fl... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when tak... |
DB00352 | DB14811 | 482 | 385 | [
"DDInter1814",
"DDInter979"
] | Tioguanine | Isatuximab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
482,
24,
385
]
],
[
[
482,
24,
1362
],
[
1362,
24,
385
]
],
[
[
482,
63,
377
],
[
377,
24,
385
]
],
[
[
482,
35,
328
],
[
328,
2... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin m... |
DB00480 | DB06636 | 1,668 | 1,623 | [
"DDInter1035",
"DDInter980"
] | Lenalidomide | Isavuconazonium | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1668,
24,
1623
]
],
[
[
1668,
24,
214
],
[
214,
63,
1623
]
],
[
[
1668,
24,
869
],
[
869,
24,
1623
]
],
[
[
1668,
25,
467
],
[
467,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Topoteca... |
DB00531 | DB14711 | 450 | 779 | [
"DDInter456",
"DDInter1680"
] | Cyclophosphamide | Smallpox (Vaccinia) Vaccine, Live | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
450,
25,
779
]
],
[
[
450,
64,
1064
],
[
1064,
25,
779
]
],
[
[
450,
25,
1377
],
[
1377,
25,
779
]
],
[
[
450,
24,
147
],
[
147,
... | [
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
... | Cyclophosphamide may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Cyclophosphamide may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may... |
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