drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00357 | DB01124 | 1,051 | 1,411 | [
"DDInter71",
"DDInter1828"
] | Aminoglutethimide | Tolbutamide | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Minor | 0 | [
[
[
1051,
23,
1411
]
],
[
[
1051,
23,
959
],
[
959,
40,
1411
]
],
[
[
1051,
62,
245
],
[
245,
40,
1411
]
],
[
[
1051,
6,
10215
],
[
10215,... | [
[
[
"Aminoglutethimide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolbutamide"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glipizide"
]... | Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide... |
DB00285 | DB00836 | 1,100 | 543 | [
"DDInter1927",
"DDInter1088"
] | Venlafaxine | Loperamide | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
1100,
24,
543
]
],
[
[
1100,
24,
649
],
[
649,
1,
543
]
],
[
[
1100,
24,
888
],
[
888,
24,
543
]
],
[
[
1100,
63,
701
],
[
701,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could... |
DB01030 | DB11943 | 869 | 255 | [
"DDInter1835",
"DDInter495"
] | Topotecan | Delafloxacin | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
869,
23,
255
]
],
[
[
869,
63,
196
],
[
196,
23,
255
]
],
[
[
869,
24,
60
],
[
60,
23,
255
]
],
[
[
869,
64,
589
],
[
589,
23,
... | [
[
[
"Topotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Altretamine"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Altretamine and Altretamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Cape... |
DB00215 | DB08881 | 1,230 | 868 | [
"DDInter388",
"DDInter1925"
] | Citalopram | Vemurafenib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1230,
25,
868
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1230,
18,
5587
],
[
5587,
57,
868
]
],
[
[
1230,
21,
29015
],
[
29015... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Citalopram (Compound) downregulates SCAND1 (Gene) and SCAND1 (Gene) is downregulated by Vemurafenib (Compound)
Citalopram (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Vemurafenib (C... |
DB08865 | DB11110 | 1,593 | 603 | [
"DDInter448",
"DDInter1115"
] | Crizotinib | Magnesium citrate | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1593,
24,
603
]
],
[
[
1593,
64,
57
],
[
57,
24,
603
]
],
[
[
1593,
25,
484
],
[
484,
63,
603
]
],
[
[
1593,
25,
1228
],
[
1228,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Crizotinib may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Crizotinib may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may ... |
DB01069 | DB01182 | 401 | 371 | [
"DDInter1533",
"DDInter1534"
] | Promethazine | Propafenone | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
401,
24,
371
]
],
[
[
401,
63,
847
],
[
847,
1,
371
]
],
[
[
401,
24,
772
],
[
772,
40,
371
]
],
[
[
401,
63,
954
],
[
954,
40,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol (Compound) resembles Propafenone (Co... |
DB00694 | DB01244 | 51 | 762 | [
"DDInter485",
"DDInter192"
] | Daunorubicin | Bepridil | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
51,
25,
762
]
],
[
[
51,
63,
675
],
[
675,
40,
762
]
],
[
[
51,
6,
4973
],
[
4973,
45,
762
]
],
[
[
51,
21,
28698
],
[
28698,
60... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
],
[
"... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Bepridil (Compound)
Daunorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Bepridil (Compound)
Daunorubicin (Compound) causes Insomnia (Side Effect... |
DB00213 | DB00903 | 837 | 1,680 | [
"DDInter1388",
"DDInter686"
] | Pantoprazole | Etacrynic acid | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Moderate | 1 | [
[
[
837,
24,
1680
]
],
[
[
837,
21,
28989
],
[
28989,
60,
1680
]
],
[
[
837,
23,
1479
],
[
1479,
62,
1680
]
],
[
[
837,
24,
126
],
[
126,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Pantoprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperuricaemia"
],
[
"Hyperuricaemia",
"{u} (Si... | Pantoprazole (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Etacrynic acid (Compound)
Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinic... |
DB01149 | DB01259 | 851 | 392 | [
"DDInter1274",
"DDInter1024"
] | Nefazodone | Lapatinib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
851,
25,
392
]
],
[
[
851,
6,
4973
],
[
4973,
45,
392
]
],
[
[
851,
21,
28688
],
[
28688,
60,
392
]
],
[
[
851,
25,
1135
],
[
1135,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapatinib"... | Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Nefazodone (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Nefazodone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a mi... |
DB00073 | DB11003 | 1,394 | 748 | [
"DDInter1608",
"DDInter100"
] | Rituximab | Anthrax vaccine | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1394,
24,
748
]
],
[
[
1394,
25,
676
],
[
676,
63,
748
]
],
[
[
1394,
24,
1683
],
[
1683,
24,
748
]
],
[
[
1394,
64,
1057
],
[
1057,
... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
"Upada... | Rituximab may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab m... |
DB01004 | DB06616 | 563 | 594 | [
"DDInter806",
"DDInter224"
] | Ganciclovir | Bosutinib | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
563,
24,
594
]
],
[
[
563,
21,
29034
],
[
29034,
60,
594
]
],
[
[
563,
63,
663
],
[
663,
24,
594
]
],
[
[
563,
24,
869
],
[
869,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Ganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Urinary tract disorder"
],
[
"Urinary tract disorder",
... | Ganciclovir (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Bosutinib (Compound)
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate d... |
DB00357 | DB09054 | 1,051 | 384 | [
"DDInter71",
"DDInter905"
] | Aminoglutethimide | Idelalisib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1051,
24,
384
]
],
[
[
1051,
24,
307
],
[
307,
23,
384
]
],
[
[
1051,
24,
907
],
[
907,
62,
384
]
],
[
[
1051,
23,
271
],
[
271,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Doravirine ... |
DB00656 | DB05812 | 827 | 1,374 | [
"DDInter1851",
"DDInter8"
] | Trazodone | Abiraterone | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
827,
24,
1374
]
],
[
[
827,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
827,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
827,
23,
112
],
[
112,... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trazodone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Trazodone (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Trazodone may cause a minor interaction that can limit clinical effects when taken... |
DB00570 | DB06772 | 147 | 310 | [
"DDInter1936",
"DDInter259"
] | Vinblastine | Cabazitaxel | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
147,
24,
310
]
],
[
[
147,
24,
973
],
[
973,
24,
310
]
],
[
[
147,
6,
4973
],
[
4973,
45,
310
]
],
[
[
147,
34,
4944
],
[
4944,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cabazitaxel (Compound)
Vinblastine (Com... |
DB01254 | DB09073 | 1,213 | 951 | [
"DDInter484",
"DDInter1379"
] | Dasatinib | Palbociclib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1213,
24,
951
]
],
[
[
1213,
23,
907
],
[
907,
62,
951
]
],
[
[
1213,
64,
318
],
[
318,
23,
951
]
],
[
[
1213,
23,
271
],
[
271,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Dasatinib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a... |
DB00640 | DB11901 | 1,585 | 913 | [
"DDInter31",
"DDInter107"
] | Adenosine | Apalutamide | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1585,
24,
913
]
],
[
[
1585,
63,
600
],
[
600,
24,
913
]
],
[
[
1585,
24,
485
],
[
485,
24,
913
]
],
[
[
1585,
24,
877
],
[
877,
... | [
[
[
"Adenosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Adenosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pent... |
DB00008 | DB05773 | 491 | 1,047 | [
"DDInter1407",
"DDInter1848"
] | Peginterferon alfa-2a | Trastuzumab emtansine | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
491,
24,
1047
]
],
[
[
491,
24,
375
],
[
375,
63,
1047
]
],
[
[
491,
24,
1112
],
[
1112,
24,
1047
]
],
[
[
491,
63,
1057
],
[
1057,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Peginterferon alfa-2a may cause a moderate interaction that could exacerba... |
DB00365 | DB09154 | 839 | 1,475 | [
"DDInter842",
"DDInter1686"
] | Grepafloxacin | Sodium citrate | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Moderate | 1 | [
[
[
839,
24,
1475
]
],
[
[
839,
24,
263
],
[
263,
23,
1475
]
],
[
[
839,
25,
1411
],
[
1411,
23,
1475
]
],
[
[
839,
24,
594
],
[
594,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium citrate"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
],
... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Axitinib and Axitinib may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Grepafloxacin may lead to a major life threatening interaction when taken with Tolbutamide and Tolbutamide may ... |
DB08868 | DB10989 | 1,011 | 496 | [
"DDInter737",
"DDInter858"
] | Fingolimod | Hepatitis A Vaccine | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1011,
24,
496
]
],
[
[
1011,
25,
1093
],
[
1093,
63,
496
]
],
[
[
1011,
64,
4
],
[
4,
24,
496
]
],
[
[
1011,
25,
850
],
[
850,
2... | [
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
],
[
"I... | Fingolimod may lead to a major life threatening interaction when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Fingolimod may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine ... |
DB00978 | DB01229 | 739 | 973 | [
"DDInter1084",
"DDInter1378"
] | Lomefloxacin | Paclitaxel (protein-bound) | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Minor | 0 | [
[
[
739,
23,
973
]
],
[
[
739,
6,
5912
],
[
5912,
45,
973
]
],
[
[
739,
6,
3199
],
[
3199,
57,
973
]
],
[
[
739,
21,
28779
],
[
28779,
... | [
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Paclitaxel"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",... | Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Paclitaxel
Lomefloxacin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Paclitaxel (Compound)
Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Paclitaxel (Compound)
Lomefloxacin (Compound... |
DB01076 | DB11718 | 700 | 927 | [
"DDInter133",
"DDInter640"
] | Atorvastatin | Encorafenib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
700,
24,
927
]
],
[
[
700,
63,
112
],
[
112,
23,
927
]
],
[
[
700,
63,
372
],
[
372,
24,
927
]
],
[
[
700,
24,
1491
],
[
1491,
2... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine ... |
DB09046 | DB09123 | 1,094 | 1,525 | [
"DDInter1201",
"DDInter546"
] | Metreleptin | Dienogest | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in... | Moderate | 1 | [
[
[
1094,
24,
1525
]
],
[
[
1094,
24,
1362
],
[
1362,
24,
1525
]
],
[
[
1094,
24,
484
],
[
484,
63,
1525
]
],
[
[
1094,
24,
927
],
[
927,
... | [
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dienogest"
]
],
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Dienogest
Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrecti... |
DB00372 | DB06707 | 999 | 584 | [
"DDInter1793",
"DDInter1060"
] | Thiethylperazine | Levonordefrin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | Moderate | 1 | [
[
[
999,
24,
584
]
],
[
[
999,
24,
1191
],
[
1191,
40,
584
]
],
[
[
999,
24,
1551
],
[
1551,
1,
584
]
],
[
[
999,
24,
401
],
[
401,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonordefrin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodopa (Compound) resembles Levonordefrin (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa (Compound) resembles Levonordefr... |
DB01191 | DB01255 | 1,039 | 633 | [
"DDInter518",
"DDInter1078"
] | Dexfenfluramine | Lisdexamfetamine | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Major | 2 | [
[
[
1039,
25,
633
]
],
[
[
1039,
64,
551
],
[
551,
1,
633
]
],
[
[
1039,
40,
11447
],
[
11447,
1,
633
]
],
[
[
1039,
64,
80
],
[
80,
... | [
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
],
[
"Phenelzin... | Dexfenfluramine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Dexfenfluramine (Compound) resembles Fenproporex (Compound) and Fenproporex (Compound) resembles Lisdexamfetamine (Compound)
Dexfenfluramine may lead to a major lif... |
DB00418 | DB00911 | 536 | 458 | [
"DDInter1650",
"DDInter1811"
] | Secobarbital | Tinidazole | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
536,
24,
458
]
],
[
[
536,
24,
112
],
[
112,
1,
458
]
],
[
[
536,
21,
28882
],
[
28882,
60,
458
]
],
[
[
536,
23,
752
],
[
752,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Secobarbital (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Tinidazole (Compound)
... |
DB00816 | DB09045 | 1,674 | 52 | [
"DDInter1346",
"DDInter607"
] | Orciprenaline | Dulaglutide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1674,
24,
52
]
],
[
[
1674,
24,
170
],
[
170,
23,
52
]
],
[
[
1674,
24,
280
],
[
280,
24,
52
]
],
[
[
1674,
63,
73
],
[
73,
24,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine ... |
DB00328 | DB08890 | 831 | 16 | [
"DDInter921",
"DDInter1069"
] | Indomethacin | Linaclotide | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin deri... | Minor | 0 | [
[
[
831,
23,
16
]
],
[
[
831,
63,
1314
],
[
1314,
40,
16
]
],
[
[
831,
24,
1512
],
[
1512,
23,
16
]
],
[
[
831,
40,
24
],
[
24,
23,
... | [
[
[
"Indomethacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Linaclotide (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a minor interaction that... |
DB01069 | DB08868 | 401 | 1,011 | [
"DDInter1533",
"DDInter737"
] | Promethazine | Fingolimod | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
401,
25,
1011
]
],
[
[
401,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
401,
21,
28817
],
[
28817,
60,
1011
]
],
[
[
401,
62,
1247
],
[
124... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fin... | Promethazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Promethazine (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Fingolimod (Compound)
Promethazine may cause a minor interaction that can limit clinical effects when taken with Sulfa... |
DB00903 | DB09472 | 1,680 | 1,383 | [
"DDInter686",
"DDInter1693"
] | Etacrynic acid | Sodium sulfate | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1680,
24,
1383
]
],
[
[
1680,
63,
104
],
[
104,
24,
1383
]
],
[
[
1680,
24,
1264
],
[
1264,
24,
1383
]
],
[
[
1680,
24,
657
],
[
657,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Doxep... |
DB00916 | DB09268 | 112 | 1,662 | [
"DDInter1202",
"DDInter1464"
] | Metronidazole | Picosulfuric acid | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
112,
24,
1662
]
],
[
[
112,
62,
1164
],
[
1164,
24,
1662
]
],
[
[
112,
23,
484
],
[
484,
63,
1662
]
],
[
[
112,
63,
595
],
[
595,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trimipramine"
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrecti... |
DB00207 | DB04868 | 1,570 | 478 | [
"DDInter157",
"DDInter1293"
] | Azithromycin | Nilotinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1570,
25,
478
]
],
[
[
1570,
6,
4973
],
[
4973,
45,
478
]
],
[
[
1570,
7,
7638
],
[
7638,
46,
478
]
],
[
[
1570,
18,
4884
],
[
4884,
... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Niloti... | Azithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Azithromycin (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Nilotinib (Compound)
Azithromycin (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Nilotinib (Compound)
Azithro... |
DB00470 | DB11632 | 530 | 580 | [
"DDInter601",
"DDInter1343"
] | Dronabinol | Opicapone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
530,
24,
580
]
],
[
[
530,
24,
104
],
[
104,
24,
580
]
],
[
[
530,
63,
999
],
[
999,
24,
580
]
],
[
[
530,
1,
1614
],
[
1614,
24... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine a... |
DB01238 | DB11730 | 673 | 351 | [
"DDInter118",
"DDInter1588"
] | Aripiprazole | Ribociclib | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
673,
24,
351
]
],
[
[
673,
62,
112
],
[
112,
23,
351
]
],
[
[
673,
63,
222
],
[
222,
23,
351
]
],
[
[
673,
24,
283
],
[
283,
62,... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Aripiprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and... |
DB00641 | DB01073 | 467 | 1,488 | [
"DDInter1675",
"DDInter745"
] | Simvastatin | Fludarabine | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
467,
24,
1488
]
],
[
[
467,
63,
372
],
[
372,
1,
1488
]
],
[
[
467,
18,
6248
],
[
6248,
45,
1488
]
],
[
[
467,
21,
28701
],
[
28701,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Simvastatin (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Fludarabine (Compound)
Simvastatin (Compound) causes Discomfort (Side Effect) and... |
DB00331 | DB01364 | 1,645 | 22 | [
"DDInter1164",
"DDInter650"
] | Metformin | Ephedrine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1645,
24,
22
]
],
[
[
1645,
24,
1529
],
[
1529,
63,
22
]
],
[
[
1645,
24,
280
],
[
280,
1,
22
]
],
[
[
1645,
21,
28680
],
[
28680,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine and ... |
DB00543 | DB00694 | 87 | 51 | [
"DDInter82",
"DDInter485"
] | Amoxapine | Daunorubicin | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
87,
24,
51
]
],
[
[
87,
7,
8606
],
[
8606,
46,
51
]
],
[
[
87,
21,
28644
],
[
28644,
60,
51
]
],
[
[
87,
23,
112
],
[
112,
62,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Amoxapine",
"{u} (Compound) upregulates {v} (Gene)",
"ALDOC"
],
[
"ALDOC",
"{u} (Gene) is upregulated by {v} (C... | Amoxapine (Compound) upregulates ALDOC (Gene) and ALDOC (Gene) is upregulated by Daunorubicin (Compound)
Amoxapine (Compound) causes Syncope (Side Effect) and Syncope (Side Effect) is caused by Daunorubicin (Compound)
Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00349 | DB01233 | 902 | 1,311 | [
"DDInter401",
"DDInter1197"
] | Clobazam | Metoclopramide | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
902,
24,
1311
]
],
[
[
902,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
902,
24,
1010
],
[
1010,
23,
1311
]
],
[
[
902,
24,
629
],
[
629,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Clobazam",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) is ca... | Clobazam (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metoclo... |
DB00694 | DB04855 | 51 | 540 | [
"DDInter485",
"DDInter602"
] | Daunorubicin | Dronedarone | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
51,
25,
540
]
],
[
[
51,
64,
347
],
[
347,
40,
540
]
],
[
[
51,
25,
33
],
[
33,
40,
540
]
],
[
[
51,
6,
8374
],
[
8374,
45,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u... | Daunorubicin may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Daunorubicin may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Daunorubicin (Compound) bi... |
DB00570 | DB06448 | 147 | 171 | [
"DDInter1936",
"DDInter1087"
] | Vinblastine | Lonafarnib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
147,
25,
171
]
],
[
[
147,
62,
63
],
[
63,
24,
171
]
],
[
[
147,
24,
112
],
[
112,
24,
171
]
],
[
[
147,
24,
310
],
[
310,
63,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Vinblastine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Teniposide"
],
[
"Teniposide... | Vinblastine may cause a minor interaction that can limit clinical effects when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Met... |
DB01097 | DB04868 | 1,377 | 478 | [
"DDInter1033",
"DDInter1293"
] | Leflunomide | Nilotinib | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1377,
25,
478
]
],
[
[
1377,
25,
1468
],
[
1468,
63,
478
]
],
[
[
1377,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1377,
18,
4930
],
[
4930,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} ma... | Leflunomide may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Leflunomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Leflunomide (Compound) downregulate... |
DB08871 | DB10989 | 36 | 496 | [
"DDInter666",
"DDInter858"
] | Eribulin | Hepatitis A Vaccine | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
36,
24,
496
]
],
[
[
36,
63,
4
],
[
4,
24,
496
]
],
[
[
36,
24,
738
],
[
738,
63,
496
]
],
[
[
36,
24,
1480
],
[
1480,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccin... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Eribulin may cause a moderate interaction that could exacerbate diseases wh... |
DB00055 | DB01240 | 834 | 885 | [
"DDInter605",
"DDInter657"
] | Drotrecogin alfa | Epoprostenol | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Major | 2 | [
[
[
834,
25,
885
]
],
[
[
834,
25,
1061
],
[
1061,
1,
885
]
],
[
[
834,
23,
539
],
[
539,
62,
885
]
],
[
[
834,
25,
1512
],
[
1512,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Treprostinil"
],
[
"Treprosti... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit c... |
DB01294 | DB06228 | 266 | 792 | [
"DDInter215",
"DDInter1609"
] | Bismuth subsalicylate | Rivaroxaban | Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of [salicylic acid] linked to trivalent [bismuth cation]. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth s... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
266,
24,
792
]
],
[
[
266,
21,
28703
],
[
28703,
60,
792
]
],
[
[
266,
63,
222
],
[
222,
24,
792
]
],
[
[
266,
63,
885
],
[
885,
... | [
[
[
"Bismuth subsalicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Bismuth subsalicylate",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} ... | Bismuth subsalicylate (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Bismuth subsalicylate may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases ... |
DB00798 | DB09135 | 1,132 | 1,211 | [
"DDInter815",
"DDInter967"
] | Gentamicin | Ioxilan | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1132,
25,
1211
]
],
[
[
1132,
64,
1028
],
[
1028,
24,
1211
]
],
[
[
1132,
25,
1680
],
[
1680,
24,
1211
]
],
[
[
1132,
24,
242
],
[
242... | [
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Torasemide"
],
[
"Torasemide",
"{u} may ... | Gentamicin may lead to a major life threatening interaction when taken with Torasemide and Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Gentamicin may lead to a major life threatening interaction when taken with Etacrynic acid and Etacrynic acid may cause a moderate... |
DB01097 | DB10989 | 1,377 | 496 | [
"DDInter1033",
"DDInter858"
] | Leflunomide | Hepatitis A Vaccine | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1377,
24,
496
]
],
[
[
1377,
25,
1093
],
[
1093,
63,
496
]
],
[
[
1377,
25,
4
],
[
4,
24,
496
]
],
[
[
1377,
64,
147
],
[
147,
2... | [
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
],
[
... | Leflunomide may lead to a major life threatening interaction when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Leflunomide may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxin... |
DB00692 | DB14881 | 274 | 180 | [
"DDInter1448",
"DDInter1329"
] | Phentolamine | Oliceridine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
274,
24,
180
]
],
[
[
274,
24,
401
],
[
401,
24,
180
]
],
[
[
274,
63,
530
],
[
530,
24,
180
]
],
[
[
274,
24,
593
],
[
593,
25,... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol a... |
DB01246 | DB04843 | 820 | 1,511 | [
"DDInter45",
"DDInter1149"
] | Alimemazine | Mepenzolate | A phenothiazine derivative that is used as an antipruritic. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
820,
24,
1511
]
],
[
[
820,
64,
675
],
[
675,
24,
1511
]
],
[
[
820,
63,
1192
],
[
1192,
24,
1511
]
],
[
[
820,
40,
649
],
[
649,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Alimemazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
[
... | Alimemazine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium an... |
DB00741 | DB01050 | 167 | 848 | [
"DDInter885",
"DDInter900"
] | Hydrocortisone | Ibuprofen | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
167,
24,
848
]
],
[
[
167,
6,
6648
],
[
6648,
45,
848
]
],
[
[
167,
21,
29404
],
[
29404,
60,
848
]
],
[
[
167,
63,
362
],
[
362,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) binds {v} (Gene)",
"SLCO1A2"
],
[
"SLCO1A2",
"{u} (Gene) is bound by {v} (Co... | Hydrocortisone (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Ibuprofen (Compound)
Hydrocortisone (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Ibuprofen (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin... |
DB00539 | DB01165 | 11 | 1,539 | [
"DDInter1837",
"DDInter1325"
] | Toremifene | Ofloxacin | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
11,
25,
1539
]
],
[
[
11,
64,
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[
1176,
1,
1539
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],
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[
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],
[
[
11,
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],
[
739,
1,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u... | Toremifene may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Toremifene may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Toremifene may lead to a... |
DB00333 | DB08875 | 576 | 1,618 | [
"DDInter1166",
"DDInter262"
] | Methadone | Cabozantinib | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
576,
25,
1618
]
],
[
[
576,
23,
112
],
[
112,
23,
1618
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[
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576,
24,
723
],
[
723,
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]
],
[
[
576,
24,
384
],
[
384,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Methadone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Apre... |
DB00604 | DB06616 | 1,425 | 594 | [
"DDInter385",
"DDInter224"
] | Cisapride | Bosutinib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1425,
25,
594
]
],
[
[
1425,
40,
883
],
[
883,
1,
594
]
],
[
[
1425,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1425,
18,
2801
],
[
2801,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Cisapride",
"{u} (Compound) resembles {v} (Compound)",
"Gefitinib"
],
[
"Gefitinib",
"{u} (Compound) resembles {v} (Compound)",
... | Cisapride (Compound) resembles Gefitinib (Compound) and Gefitinib (Compound) resembles Bosutinib (Compound)
Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Cisapride (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Bosutinib (Compound)
Cisapride may ... |
DB00370 | DB11986 | 1,251 | 484 | [
"DDInter1230",
"DDInter648"
] | Mirtazapine | Entrectinib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1251,
24,
484
]
],
[
[
1251,
23,
112
],
[
112,
23,
484
]
],
[
[
1251,
25,
222
],
[
222,
23,
484
]
],
[
[
1251,
24,
774
],
[
774,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Mirtazapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Mirtazapine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may... |
DB06706 | DB14754 | 468 | 1,663 | [
"DDInter985",
"DDInter1697"
] | Isometheptene | Solriamfetol | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label]. | Moderate | 1 | [
[
[
468,
24,
1663
]
],
[
[
468,
63,
1674
],
[
1674,
24,
1663
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],
[
[
468,
24,
144
],
[
144,
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1663
]
],
[
[
468,
64,
1053
],
[
1053,
... | [
[
[
"Isometheptene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solriamfetol"
]
],
[
[
"Isometheptene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
... | Isometheptene may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Solriamfetol
Isometheptene may cause a moderate interaction that could exacerbate diseases when taken with Olodate... |
DB01097 | DB12159 | 1,377 | 12 | [
"DDInter1033",
"DDInter609"
] | Leflunomide | Dupilumab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Major | 2 | [
[
[
1377,
25,
12
]
],
[
[
1377,
62,
1461
],
[
1461,
23,
12
]
],
[
[
1377,
23,
1114
],
[
1114,
23,
12
]
],
[
[
1377,
64,
599
],
[
599,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dupilumab"
]
],
[
[
"Leflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Leflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Dupilumab
Leflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfat... |
DB00851 | DB08826 | 611 | 1,292 | [
"DDInter463",
"DDInter489"
] | Dacarbazine | Deferiprone | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
611,
25,
1292
]
],
[
[
611,
63,
482
],
[
482,
25,
1292
]
],
[
[
611,
24,
4
],
[
4,
25,
1292
]
],
[
[
611,
64,
1064
],
[
1064,
25... | [
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
[
"Tioguan... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may lead to a major life threatening interaction when taken with Deferiprone
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Oma... |
DB01181 | DB09068 | 1,532 | 1,427 | [
"DDInter906",
"DDInter1948"
] | Ifosfamide | Vortioxetine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1532,
24,
1427
]
],
[
[
1532,
24,
1017
],
[
1017,
63,
1427
]
],
[
[
1532,
24,
129
],
[
129,
24,
1427
]
],
[
[
1532,
63,
959
],
[
959,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and En... |
DB00736 | DB08899 | 660 | 129 | [
"DDInter676",
"DDInter649"
] | Esomeprazole | Enzalutamide | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
660,
24,
129
]
],
[
[
660,
6,
8374
],
[
8374,
45,
129
]
],
[
[
660,
21,
28703
],
[
28703,
60,
129
]
],
[
[
660,
63,
529
],
[
529,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Esomeprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Esomeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Esomeprazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine... |
DB01281 | DB08880 | 881 | 1,510 | [
"DDInter5",
"DDInter1771"
] | Abatacept | Teriflunomide | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
881,
25,
1510
]
],
[
[
881,
62,
1461
],
[
1461,
23,
1510
]
],
[
[
881,
23,
1193
],
[
1193,
62,
1510
]
],
[
[
881,
24,
221
],
[
221,
... | [
[
[
"Abatacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Abatacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Abatacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Abatacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluc... |
DB00400 | DB04855 | 353 | 540 | [
"DDInter843",
"DDInter602"
] | Griseofulvin | Dronedarone | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
353,
24,
540
]
],
[
[
353,
6,
8374
],
[
8374,
45,
540
]
],
[
[
353,
21,
28746
],
[
28746,
60,
540
]
],
[
[
353,
24,
466
],
[
466,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Griseofulvin (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Dronedarone (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide ... |
DB06228 | DB12010 | 792 | 214 | [
"DDInter1609",
"DDInter785"
] | Rivaroxaban | Fostamatinib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
792,
24,
214
]
],
[
[
792,
63,
723
],
[
723,
24,
214
]
],
[
[
792,
62,
307
],
[
307,
24,
214
]
],
[
[
792,
24,
179
],
[
179,
63,... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Rivaroxaban may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modaf... |
DB01246 | DB01324 | 820 | 178 | [
"DDInter45",
"DDInter1490"
] | Alimemazine | Polythiazide | A phenothiazine derivative that is used as an antipruritic. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
820,
24,
178
]
],
[
[
820,
63,
504
],
[
504,
40,
178
]
],
[
[
820,
21,
28824
],
[
28824,
60,
178
]
],
[
[
820,
63,
85
],
[
85,
2... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Alimemazine (Compound) causes Jaundice cholestatic (Side Effect) and Jaundice cholestatic (Side Effect) is caused by Polythiazide (Compound... |
DB01220 | DB11581 | 1,088 | 1,456 | [
"DDInter1593",
"DDInter1926"
] | Rifaximin | Venetoclax | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
1088,
24,
1456
]
],
[
[
1088,
24,
241
],
[
241,
63,
1456
]
],
[
[
1088,
63,
126
],
[
126,
24,
1456
]
],
[
[
1088,
24,
165
],
[
165,
... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
],
[
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib and Erdafitinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin... |
DB00261 | DB01208 | 702 | 945 | [
"DDInter93",
"DDInter1705"
] | Anagrelide | Sparfloxacin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
702,
25,
945
]
],
[
[
702,
25,
739
],
[
739,
1,
945
]
],
[
[
702,
64,
1176
],
[
1176,
1,
945
]
],
[
[
702,
18,
2183
],
[
2183,
5... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Anagrelide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Compound)
Anagrelide (Compou... |
DB01166 | DB11793 | 477 | 738 | [
"DDInter379",
"DDInter1297"
] | Cilostazol | Niraparib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
477,
24,
738
]
],
[
[
477,
25,
1213
],
[
1213,
24,
738
]
],
[
[
477,
64,
1578
],
[
1578,
24,
738
]
],
[
[
477,
63,
463
],
[
463,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Cilostazol may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Cilostazol may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interacti... |
DB09030 | DB12010 | 840 | 214 | [
"DDInter1945",
"DDInter785"
] | Vorapaxar | Fostamatinib | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
840,
24,
214
]
],
[
[
840,
24,
179
],
[
179,
63,
214
]
],
[
[
840,
24,
738
],
[
738,
24,
214
]
],
[
[
840,
25,
1155
],
[
1155,
2... | [
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
],
... | Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl and Telotristat ethyl may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Nirapar... |
DB00427 | DB00899 | 1,233 | 411 | [
"DDInter1879",
"DDInter1579"
] | Triprolidine | Remifentanil | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Moderate | 1 | [
[
[
1233,
24,
411
]
],
[
[
1233,
24,
1322
],
[
1322,
40,
411
]
],
[
[
1233,
24,
704
],
[
704,
1,
411
]
],
[
[
1233,
24,
662
],
[
662,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil (Compound) resembles Remifentanil (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Remifentanil (Compou... |
DB00872 | DB01211 | 1,080 | 609 | [
"DDInter438",
"DDInter393"
] | Conivaptan | Clarithromycin | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
1080,
25,
609
]
],
[
[
1080,
6,
8374
],
[
8374,
45,
609
]
],
[
[
1080,
21,
28803
],
[
28803,
60,
609
]
],
[
[
1080,
63,
1601
],
[
1601... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Conivaptan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cla... | Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Conivaptan (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Clarithromycin (Compound)
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and ... |
DB04938 | DB09038 | 1,423 | 1,450 | [
"DDInter1353",
"DDInter636"
] | Ospemifene | Empagliflozin | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1423,
24,
1450
]
],
[
[
1423,
1,
485
],
[
485,
24,
1450
]
],
[
[
1423,
24,
913
],
[
913,
63,
1450
]
],
[
[
1423,
24,
129
],
[
129,
... | [
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Ospemifene",
"{u} (Compound) resembles {v} (Compound)",
"Pentamidine"
],
[
"Pentamidine",
"{u} may cause a mo... | Ospemifene (Compound) resembles Pentamidine (Compound) and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction tha... |
DB00607 | DB09268 | 1,249 | 1,662 | [
"DDInter1256",
"DDInter1464"
] | Nafcillin | Picosulfuric acid | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1249,
24,
1662
]
],
[
[
1249,
25,
484
],
[
484,
63,
1662
]
],
[
[
1249,
24,
1618
],
[
1618,
24,
1662
]
],
[
[
1249,
63,
597
],
[
597,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"Entr... | Nafcillin may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib... |
DB00738 | DB00845 | 485 | 1,490 | [
"DDInter1420",
"DDInter406"
] | Pentamidine | Clofazimine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Moderate | 1 | [
[
[
485,
24,
1490
]
],
[
[
485,
6,
8374
],
[
8374,
45,
1490
]
],
[
[
485,
21,
28787
],
[
28787,
60,
1490
]
],
[
[
485,
23,
112
],
[
112,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofazimine"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clofazimine (Compound)
Pentamidine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Clofazimine (Compound)
Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00252 | DB00912 | 362 | 473 | [
"DDInter1460",
"DDInter1581"
] | Phenytoin | Repaglinide | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
362,
24,
473
]
],
[
[
362,
6,
1829
],
[
1829,
45,
473
]
],
[
[
362,
21,
28763
],
[
28763,
60,
473
]
],
[
[
362,
24,
609
],
[
609,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenytoin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Repaglinide (Compound)
Phenytoin (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Repaglinide (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clari... |
DB00524 | DB06655 | 811 | 5 | [
"DDInter1199",
"DDInter1077"
] | Metolazone | Liraglutide | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
811,
24,
5
]
],
[
[
811,
24,
870
],
[
870,
24,
5
]
],
[
[
811,
63,
245
],
[
245,
24,
5
]
],
[
[
811,
1,
1605
],
[
1605,
24,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Glimepirid... |
DB00286 | DB06404 | 380 | 1,514 | [
"DDInter439",
"DDInter869"
] | Conjugated estrogens | Human C1-esterase inhibitor | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Moderate | 1 | [
[
[
380,
24,
1514
]
],
[
[
380,
40,
1438
],
[
1438,
24,
1514
]
],
[
[
380,
1,
35
],
[
35,
24,
1514
]
],
[
[
380,
25,
350
],
[
350,
6... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human C1-esterase inhibitor"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) resembles {v} (Compound)",
"Estradiol"
],
[
"Estradi... | Conjugated estrogens (Compound) resembles Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Conjugated estrogens (Compound) resembles Quinestrol (Compound) and Quinestrol may cause a moderate interaction that could exacerbate d... |
DB00408 | DB01075 | 1,408 | 1,376 | [
"DDInter1099",
"DDInter569"
] | Loxapine | Diphenhydramine | An antipsychotic agent used in schizophrenia. [PubChem] | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1408,
24,
1376
]
],
[
[
1408,
24,
649
],
[
649,
63,
1376
]
],
[
[
1408,
63,
128
],
[
128,
24,
1376
]
],
[
[
1408,
24,
832
],
[
832,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine a... |
DB00197 | DB06616 | 1,324 | 594 | [
"DDInter1881",
"DDInter224"
] | Troglitazone | Bosutinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1324,
24,
594
]
],
[
[
1324,
24,
883
],
[
883,
1,
594
]
],
[
[
1324,
24,
786
],
[
786,
63,
594
]
],
[
[
1324,
24,
1215
],
[
1215,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine may cause a moderate interaction that co... |
DB00307 | DB09143 | 1,101 | 313 | [
"DDInter202",
"DDInter1701"
] | Bexarotene | Sonidegib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Moderate | 1 | [
[
[
1101,
24,
313
]
],
[
[
1101,
25,
478
],
[
478,
24,
313
]
],
[
[
1101,
24,
1478
],
[
1478,
24,
313
]
],
[
[
1101,
24,
1375
],
[
1375,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sonidegib"
]
],
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
... | Bexarotene may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sonidegib
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a mod... |
DB00002 | DB04865 | 1,284 | 4 | [
"DDInter344",
"DDInter1335"
] | Cetuximab | Omacetaxine mepesuccinate | Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1284,
24,
4
]
],
[
[
1284,
25,
770
],
[
770,
24,
4
]
],
[
[
1284,
24,
589
],
[
589,
24,
4
]
],
[
[
1284,
24,
384
],
[
384,
63,
... | [
[
[
"Cetuximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Cetuximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
],
[
... | Cetuximab may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Cetuximab may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplat... |
DB00470 | DB01176 | 530 | 537 | [
"DDInter601",
"DDInter453"
] | Dronabinol | Cyclizine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
530,
24,
537
]
],
[
[
530,
63,
1242
],
[
1242,
24,
537
]
],
[
[
530,
24,
104
],
[
104,
1,
537
]
],
[
[
530,
24,
601
],
[
601,
40... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methd... |
DB00557 | DB12245 | 252 | 823 | [
"DDInter895",
"DDInter1863"
] | Hydroxyzine | Triclabendazole | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
252,
24,
823
]
],
[
[
252,
23,
112
],
[
112,
23,
823
]
],
[
[
252,
63,
1010
],
[
1010,
24,
823
]
],
[
[
252,
24,
28
],
[
28,
24,... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Hydroxyzine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB00502 | DB00877 | 1,300 | 629 | [
"DDInter853",
"DDInter1678"
] | Haloperidol | Sirolimus | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1300,
24,
629
]
],
[
[
1300,
6,
4973
],
[
4973,
45,
629
]
],
[
[
1300,
18,
2183
],
[
2183,
57,
629
]
],
[
[
1300,
6,
3769
],
[
3769,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Haloperidol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Haloperidol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Haloperidol (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Sirolimus (Compound)
Haloperidol (Compound) binds EBP (Gene) and EBP (Gene) is downregulated by Sirolimus (Compound)
Haloperidol (Compound) c... |
DB04911 | DB09268 | 968 | 1,662 | [
"DDInter1347",
"DDInter1464"
] | Oritavancin | Picosulfuric acid | Oritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). Oritavancin was initially approved by the FDA in 2014 and formulated to combat susceptible gram-positive bacteria that cause skin and skin structure infections. It boasts... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
968,
24,
1662
]
],
[
[
968,
24,
484
],
[
484,
63,
1662
]
],
[
[
968,
24,
1618
],
[
1618,
24,
1662
]
],
[
[
968,
40,
91
],
[
91,
... | [
[
[
"Oritavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Oritavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Oritavancin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Oritavancin may cause a moderate interaction that could exacerbate diseases when taken with Cabozantin... |
DB01136 | DB06603 | 772 | 39 | [
"DDInter305",
"DDInter1387"
] | Carvedilol | Panobinostat | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
772,
24,
39
]
],
[
[
772,
64,
455
],
[
455,
24,
39
]
],
[
[
772,
23,
578
],
[
578,
63,
39
]
],
[
[
772,
63,
1419
],
[
1419,
24,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Carvedilol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Salmeterol"
],
[
"Salmeter... | Carvedilol may lead to a major life threatening interaction when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Carvedilol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor may cause ... |
DB00182 | DB09104 | 80 | 286 | [
"DDInter84",
"DDInter1118"
] | Amphetamine | Magnesium hydroxide | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
80,
24,
286
]
],
[
[
80,
24,
820
],
[
820,
23,
286
]
],
[
[
80,
40,
633
],
[
633,
24,
286
]
],
[
[
80,
24,
688
],
[
688,
24,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Amphetamine (Compound) resembles Lisdexamfetamine (Compound) and Lisdexamfetamine may cause a moderate... |
DB06343 | DB08907 | 1,379 | 1,344 | [
"DDInter1766",
"DDInter280"
] | Teprotumumab | Canagliflozin | Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by th... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1379,
24,
1344
]
],
[
[
1379,
63,
549
],
[
549,
1,
1344
]
],
[
[
1379,
63,
176
],
[
176,
24,
1344
]
],
[
[
1379,
24,
1296
],
[
1296,
... | [
[
[
"Teprotumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Teprotumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Teprotumumab may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Teprotumumab may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a modera... |
DB00398 | DB01064 | 79 | 1,148 | [
"DDInter1702",
"DDInter987"
] | Sorafenib | Isoprenaline | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
79,
24,
1148
]
],
[
[
79,
24,
480
],
[
480,
24,
1148
]
],
[
[
79,
7,
2969
],
[
2969,
46,
1148
]
],
[
[
79,
21,
28717
],
[
28717,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Sorafenib (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Isoprenaline (Compound)
Sora... |
DB00860 | DB01309 | 891 | 1,254 | [
"DDInter1513",
"DDInter933"
] | Prednisolone | Insulin glulisine | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
891,
24,
1254
]
],
[
[
891,
40,
1103
],
[
1103,
23,
1254
]
],
[
[
891,
40,
167
],
[
167,
24,
1254
]
],
[
[
891,
24,
1603
],
[
1603,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} may caus... | Prednisolone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Prednisolone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken... |
DB00795 | DB00861 | 50 | 914 | [
"DDInter1725",
"DDInter551"
] | Sulfasalazine | Diflunisal | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
50,
24,
914
]
],
[
[
50,
40,
712
],
[
712,
63,
914
]
],
[
[
50,
34,
7720
],
[
7720,
45,
914
]
],
[
[
50,
6,
10522
],
[
10522,
45... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Sulfasalazine",
"{u} (Compound) resembles {v} (Compound)",
"Olsalazine"
],
[
"Olsalazine",
"{u} may cause a m... | Sulfasalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Sulfasalazine (Compound) binds PTGS2 (Gene) and Sulfasalazine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Diflunisal (Compound)
Sulfasal... |
DB01110 | DB08820 | 86 | 1,478 | [
"DDInter1209",
"DDInter997"
] | Miconazole | Ivacaftor | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
86,
24,
1478
]
],
[
[
86,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
86,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
86,
23,
907
],
[
907,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Miconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Miconazole (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Miconazole may cause a minor interaction that can limit clinical effects when taken with Doravirine and Dora... |
DB06663 | DB09564 | 1,154 | 1,296 | [
"DDInter1398",
"DDInter930"
] | Pasireotide | Insulin degludec | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1154,
24,
1296
]
],
[
[
1154,
64,
17
],
[
17,
24,
1296
]
],
[
[
1154,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1154,
24,
659
],
[
659,
... | [
[
[
"Pasireotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotal... | Pasireotide may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may ca... |
DB00857 | DB01142 | 1,387 | 1,264 | [
"DDInter1768",
"DDInter593"
] | Terbinafine | Doxepin | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1387,
24,
1264
]
],
[
[
1387,
63,
508
],
[
508,
24,
1264
]
],
[
[
1387,
24,
401
],
[
401,
24,
1264
]
],
[
[
1387,
6,
6017
],
[
6017,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prometh... |
DB00465 | DB00761 | 886 | 1,621 | [
"DDInter1010",
"DDInter1497"
] | Ketorolac | Potassium chloride | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Moderate | 1 | [
[
[
886,
24,
1621
]
],
[
[
886,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
886,
25,
1512
],
[
1512,
24,
1621
]
],
[
[
886,
25,
848
],
[
848,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium chloride"
]
],
[
[
"Ketorolac",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) i... | Ketorolac (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Ketorolac may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Potassium chlori... |
DB00001 | DB01381 | 1,578 | 958 | [
"DDInter1037",
"DDInter819"
] | Lepirudin | Ginkgo biloba | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1578,
24,
958
]
],
[
[
1578,
25,
1347
],
[
1347,
24,
958
]
],
[
[
1578,
24,
121
],
[
121,
24,
958
]
],
[
[
1578,
25,
792
],
[
792,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
"Clopidog... | Lepirudin may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may... |
DB06335 | DB11943 | 761 | 255 | [
"DDInter1646",
"DDInter495"
] | Saxagliptin | Delafloxacin | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
761,
24,
255
]
],
[
[
761,
24,
1320
],
[
1320,
63,
255
]
],
[
[
761,
24,
913
],
[
913,
24,
255
]
],
[
[
761,
63,
1324
],
[
1324,
... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalu... |
DB09030 | DB14357 | 840 | 944 | [
"DDInter1945",
"DDInter347"
] | Vorapaxar | Chamomile | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
840,
23,
944
]
],
[
[
840,
64,
256
],
[
256,
23,
944
]
],
[
[
840,
25,
498
],
[
498,
23,
944
]
],
[
[
840,
63,
1061
],
[
1061,
2... | [
[
[
"Vorapaxar",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Vorapaxar may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Vorapaxar may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a minor interaction that c... |
DB00758 | DB08918 | 1,347 | 41 | [
"DDInter413",
"DDInter1059"
] | Clopidogrel | Levomilnacipran | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1347,
24,
41
]
],
[
[
1347,
24,
901
],
[
901,
40,
41
]
],
[
[
1347,
63,
1349
],
[
1349,
40,
41
]
],
[
[
1347,
6,
10215
],
[
10215,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Levomilnacipr... |
DB00701 | DB01229 | 1,091 | 973 | [
"DDInter90",
"DDInter1377"
] | Amprenavir | Paclitaxel | Amprenavir is a protease inhibitor used to treat HIV infection. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Major | 2 | [
[
[
1091,
25,
973
]
],
[
[
1091,
24,
310
],
[
310,
63,
973
]
],
[
[
1091,
6,
7524
],
[
7524,
45,
973
]
],
[
[
1091,
21,
29267
],
[
29267,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitax... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Amprenavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Amprenavir (Comp... |
DB00877 | DB08901 | 629 | 1,468 | [
"DDInter1678",
"DDInter1492"
] | Sirolimus | Ponatinib | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
629,
24,
1468
]
],
[
[
629,
24,
478
],
[
478,
24,
1468
]
],
[
[
629,
6,
7524
],
[
7524,
45,
1468
]
],
[
[
629,
7,
7478
],
[
7478,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Sirolimus (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ponatinib (Compound)
Sirolimus (Compound) upr... |
DB00798 | DB01009 | 1,132 | 935 | [
"DDInter815",
"DDInter1009"
] | Gentamicin | Ketoprofen | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1132,
24,
935
]
],
[
[
1132,
63,
1274
],
[
1274,
24,
935
]
],
[
[
1132,
24,
1263
],
[
1263,
1,
935
]
],
[
[
1132,
63,
886
],
[
886,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bro... |
DB01599 | DB11986 | 1,232 | 484 | [
"DDInter1523",
"DDInter648"
] | Probucol | Entrectinib | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1232,
24,
484
]
],
[
[
1232,
62,
112
],
[
112,
23,
484
]
],
[
[
1232,
24,
774
],
[
774,
24,
484
]
],
[
[
1232,
63,
1674
],
[
1674,
... | [
[
[
"Probucol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Probucol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degareli... |
DB00539 | DB01263 | 11 | 859 | [
"DDInter1837",
"DDInter1494"
] | Toremifene | Posaconazole | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Major | 2 | [
[
[
11,
25,
859
]
],
[
[
11,
6,
4973
],
[
4973,
45,
859
]
],
[
[
11,
21,
28762
],
[
28762,
60,
859
]
],
[
[
11,
23,
112
],
[
112,
23... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Posaconazole"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Posacon... | Toremifene (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Toremifene (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Toremifene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
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