drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00024 | DB06203 | 818 | 1,002 | [
"DDInter1800",
"DDInter51"
] | Thyrotropin alfa | Alogliptin | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
818,
24,
1002
]
],
[
[
818,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
818,
24,
176
],
[
176,
24,
1002
]
],
[
[
818,
24,
1296
],
[
1296,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moder... |
DB06691 | DB12161 | 849 | 730 | [
"DDInter1155",
"DDInter512"
] | Mepyramine | Deutetrabenazine | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
849,
24,
730
]
],
[
[
849,
74,
100
],
[
100,
24,
730
]
],
[
[
849,
63,
1264
],
[
1264,
24,
730
]
],
[
[
849,
24,
407
],
[
407,
2... | [
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Mepyramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when t... | Mepyramine (Compound) resembles Brompheniramine (Compound) and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Mepyramine may cause a moderate i... |
DB00065 | DB10316 | 581 | 334 | [
"DDInter923",
"DDInter1248"
] | Infliximab | Mumps virus strain B level jeryl lynn live antigen | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
581,
25,
334
]
],
[
[
581,
25,
1042
],
[
1042,
24,
334
]
],
[
[
581,
25,
594
],
[
594,
25,
334
]
],
[
[
581,
64,
1057
],
[
1057,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetracosactide"
... | Infliximab may lead to a major life threatening interaction when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Mumps virus strain B level jeryl lynn live antigen
Infliximab may lead to a major life threatening interaction when taken with Bos... |
DB04845 | DB08904 | 309 | 375 | [
"DDInter1001",
"DDInter342"
] | Ixabepilone | Certolizumab pegol | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
309,
25,
375
]
],
[
[
309,
63,
1461
],
[
1461,
23,
375
]
],
[
[
309,
63,
231
],
[
231,
24,
375
]
],
[
[
309,
24,
1047
],
[
1047,
... | [
[
[
"Ixabepilone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"V... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and S... |
DB00604 | DB09118 | 1,425 | 1,580 | [
"DDInter385",
"DDInter1711"
] | Cisapride | Stiripentol | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Major | 2 | [
[
[
1425,
25,
1580
]
],
[
[
1425,
25,
283
],
[
283,
63,
1580
]
],
[
[
1425,
64,
79
],
[
79,
24,
1580
]
],
[
[
1425,
25,
478
],
[
478,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stiripentol"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{u} ma... | Cisapride may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Cisapride may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a moderate interac... |
DB00196 | DB06288 | 600 | 607 | [
"DDInter743",
"DDInter77"
] | Fluconazole | Amisulpride | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
600,
25,
607
]
],
[
[
600,
21,
29232
],
[
29232,
60,
607
]
],
[
[
600,
23,
112
],
[
112,
23,
607
]
],
[
[
600,
24,
1559
],
[
1559,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Fluconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is caused by {v} (C... | Fluconazole (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Am... |
DB00455 | DB11652 | 1,601 | 1,155 | [
"DDInter1091",
"DDInter1891"
] | Loratadine | Tucatinib | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
1601,
24,
1155
]
],
[
[
1601,
23,
609
],
[
609,
24,
1155
]
],
[
[
1601,
24,
1419
],
[
1419,
24,
1155
]
],
[
[
1601,
24,
214
],
[
214,
... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Loratadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
],
[
... | Loratadine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Tucatinib
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Ima... |
DB00361 | DB01118 | 134 | 33 | [
"DDInter1939",
"DDInter76"
] | Vinorelbine | Amiodarone | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
134,
24,
33
]
],
[
[
134,
24,
540
],
[
540,
1,
33
]
],
[
[
134,
6,
4973
],
[
4973,
45,
33
]
],
[
[
134,
7,
9650
],
[
9650,
46,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Vinorelbine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amiodarone (Compound)
Vinorelbine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gen... |
DB00598 | DB01041 | 1,523 | 770 | [
"DDInter1013",
"DDInter1789"
] | Labetalol | Thalidomide | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1523,
24,
770
]
],
[
[
1523,
21,
28789
],
[
28789,
60,
770
]
],
[
[
1523,
24,
849
],
[
849,
63,
770
]
],
[
[
1523,
40,
633
],
[
633,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Labetalol",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
"{u... | Labetalol (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases ... |
DB00014 | DB00529 | 521 | 789 | [
"DDInter839",
"DDInter779"
] | Goserelin | Foscarnet | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Moderate | 1 | [
[
[
521,
24,
789
]
],
[
[
521,
21,
29106
],
[
29106,
60,
789
]
],
[
[
521,
23,
112
],
[
112,
62,
789
]
],
[
[
521,
24,
1494
],
[
1494,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Foscarnet"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Myalgia"
],
[
"Myalgia",
"{u} (Side Effect) is caused by {... | Goserelin (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Foscarnet (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Foscarnet
Go... |
DB01254 | DB06626 | 1,213 | 263 | [
"DDInter484",
"DDInter147"
] | Dasatinib | Axitinib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
1213,
24,
263
]
],
[
[
1213,
64,
1215
],
[
1215,
23,
263
]
],
[
[
1213,
24,
1475
],
[
1475,
62,
263
]
],
[
[
1213,
24,
1283
],
[
1283,... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lansoprazole"
],
[
"Lansoprazole... | Dasatinib may lead to a major life threatening interaction when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Sodium citrate and Sodium citrate may ... |
DB00275 | DB11901 | 217 | 913 | [
"DDInter1330",
"DDInter107"
] | Olmesartan | Apalutamide | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
217,
24,
913
]
],
[
[
217,
24,
1450
],
[
1450,
24,
913
]
],
[
[
217,
1,
240
],
[
240,
24,
913
]
],
[
[
217,
24,
593
],
[
593,
25... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Olmesartan (Compound) resembles Losartan (Compound) and Losartan may cause a moderate interaction that co... |
DB00562 | DB11057 | 1,014 | 720 | [
"DDInter188",
"DDInter1223"
] | Benzthiazide | Mineral oil | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1014,
24,
720
]
],
[
[
1014,
24,
175
],
[
175,
24,
720
]
],
[
[
1014,
1,
323
],
[
323,
24,
720
]
],
[
[
1014,
63,
160
],
[
160,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Benzthiazide (Compound) resembles Bendroflumethiazide (Compound) and Bendroflumethiazide may cause a mo... |
DB00281 | DB00812 | 608 | 998 | [
"DDInter1066",
"DDInter1451"
] | Lidocaine | Phenylbutazone | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Minor | 0 | [
[
[
608,
23,
998
]
],
[
[
608,
23,
804
],
[
804,
40,
998
]
],
[
[
608,
24,
902
],
[
902,
40,
998
]
],
[
[
608,
23,
307
],
[
307,
1,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfinpyrazone"
],
[
... | Lidocaine may cause a minor interaction that can limit clinical effects when taken with Sulfinpyrazone and Sulfinpyrazone (Compound) resembles Phenylbutazone (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Phenylbutazone (Co... |
DB00341 | DB10429 | 1,242 | 200 | [
"DDInter343",
"DDInter282"
] | Cetirizine | Candida albicans | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1242,
24,
200
]
],
[
[
1242,
40,
1413
],
[
1413,
24,
200
]
],
[
[
1242,
74,
701
],
[
701,
24,
200
]
],
[
[
1242,
24,
662
],
[
662,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Cetirizine",
"{u} (Compound) resembles {v} (Compound)",
"Fexofenadine"
],
[
"Fexofenadine",
"{u} may cause... | Cetirizine (Compound) resembles Fexofenadine (Compound) and Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Cetirizine (Compound) resembles Clemastine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with C... |
DB00552 | DB00619 | 1,238 | 1,419 | [
"DDInter1425",
"DDInter909"
] | Pentostatin | Imatinib | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
1238,
24,
1419
]
],
[
[
1238,
5,
11555
],
[
11555,
44,
1419
]
],
[
[
1238,
21,
28970
],
[
28970,
60,
1419
]
],
[
[
1238,
63,
599
],
[
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Pentostatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Diseas... | Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Imatinib (Compound)
Pentostatin (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Imatinib (Compound)
Pentostatin may cause a moderate interaction that could exacerbate diseases when ta... |
DB01069 | DB06176 | 401 | 1,342 | [
"DDInter1533",
"DDInter1616"
] | Promethazine | Romidepsin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
401,
24,
1342
]
],
[
[
401,
62,
1247
],
[
1247,
23,
1342
]
],
[
[
401,
24,
336
],
[
336,
24,
1342
]
],
[
[
401,
63,
956
],
[
956,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Promethazine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Nifedipin... |
DB01234 | DB06176 | 1,220 | 1,342 | [
"DDInter513",
"DDInter1616"
] | Dexamethasone | Romidepsin | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1220,
24,
1342
]
],
[
[
1220,
63,
336
],
[
336,
24,
1342
]
],
[
[
1220,
64,
956
],
[
956,
24,
1342
]
],
[
[
1220,
25,
786
],
[
786,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Dexamethasone may lead to a major life threatening interaction when taken with Norfloxacin and Norfloxacin ma... |
DB00224 | DB00414 | 215 | 590 | [
"DDInter917",
"DDInter16"
] | Indinavir | Acetohexamide | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
215,
24,
590
]
],
[
[
215,
24,
660
],
[
660,
62,
590
]
],
[
[
215,
25,
1017
],
[
1017,
63,
590
]
],
[
[
215,
63,
168
],
[
168,
2... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
],
[... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Indinavir may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cau... |
DB00455 | DB00559 | 1,601 | 152 | [
"DDInter1091",
"DDInter223"
] | Loratadine | Bosentan | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Moderate | 1 | [
[
[
1601,
24,
152
]
],
[
[
1601,
6,
6017
],
[
6017,
45,
152
]
],
[
[
1601,
21,
29402
],
[
29402,
60,
152
]
],
[
[
1601,
24,
1478
],
[
1478... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
]
],
[
[
"Loratadine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Loratadine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bosentan (Compound)
Loratadine (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Bosentan (Compound)
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00261 | DB01211 | 702 | 609 | [
"DDInter93",
"DDInter393"
] | Anagrelide | Clarithromycin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
702,
25,
609
]
],
[
[
702,
64,
1570
],
[
1570,
24,
609
]
],
[
[
702,
6,
7950
],
[
7950,
45,
609
]
],
[
[
702,
18,
10375
],
[
10375,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
"Azithromycin",
... | Anagrelide may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clarithromycin (Compound)
Anagrelide (Compound)... |
DB00001 | DB04896 | 1,578 | 901 | [
"DDInter1037",
"DDInter1220"
] | Lepirudin | Milnacipran | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1578,
24,
901
]
],
[
[
1578,
24,
41
],
[
41,
1,
901
]
],
[
[
1578,
25,
405
],
[
405,
63,
901
]
],
[
[
1578,
25,
500
],
[
500,
24... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Lepirudin may lead to a major life threatening interaction when taken with Acalabrutinib and Acalabrutinib may cause a moderate interaction that could... |
DB00773 | DB01073 | 896 | 1,488 | [
"DDInter702",
"DDInter745"
] | Etoposide | Fludarabine | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
896,
24,
1488
]
],
[
[
896,
63,
372
],
[
372,
1,
1488
]
],
[
[
896,
5,
11555
],
[
11555,
44,
1488
]
],
[
[
896,
21,
28701
],
[
28701,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Fludarabine (Compound)
Etoposide (Compound) causes Dis... |
DB00072 | DB06688 | 550 | 1,430 | [
"DDInter1846",
"DDInter1677"
] | Trastuzumab | Sipuleucel-T | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
550,
24,
1430
]
],
[
[
550,
25,
51
],
[
51,
24,
1430
]
],
[
[
550,
24,
869
],
[
869,
24,
1430
]
],
[
[
550,
25,
676
],
[
676,
63... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daunorubicin"
],
[
"Daun... | Trastuzumab may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may ... |
DB01259 | DB12147 | 392 | 241 | [
"DDInter1024",
"DDInter661"
] | Lapatinib | Erdafitinib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
392,
24,
241
]
],
[
[
392,
25,
1456
],
[
1456,
24,
241
]
],
[
[
392,
25,
982
],
[
982,
63,
241
]
],
[
[
392,
64,
1425
],
[
1425,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
],
[
"Venetoclax"... | Lapatinib may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Lapatinib may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate inter... |
DB00035 | DB00543 | 1,314 | 87 | [
"DDInter507",
"DDInter82"
] | Desmopressin | Amoxapine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Moderate | 1 | [
[
[
1314,
24,
87
]
],
[
[
1314,
21,
29134
],
[
29134,
60,
87
]
],
[
[
1314,
24,
1148
],
[
1148,
63,
87
]
],
[
[
1314,
24,
475
],
[
475,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
]
],
[
[
"Desmopressin",
"{u} (Compound) causes {v} (Side Effect)",
"Flatulence"
],
[
"Flatulence",
"{u} (Side Effect) is... | Desmopressin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Amoxapine (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01764 | DB06616 | 805 | 594 | [
"DDInter469",
"DDInter224"
] | Dalfopristin | Bosutinib | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
805,
25,
594
]
],
[
[
805,
63,
883
],
[
883,
1,
594
]
],
[
[
805,
6,
8374
],
[
8374,
45,
594
]
],
[
[
805,
63,
1215
],
[
1215,
2... | [
[
[
"Dalfopristin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitini... | Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Dalfopristin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Dalfopristin may cause a moderate interaction that could exacerbat... |
DB01057 | DB01176 | 1,318 | 537 | [
"DDInter615",
"DDInter453"
] | Echothiophate (ophthalmic) | Cyclizine | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1318,
24,
537
]
],
[
[
1318,
63,
104
],
[
104,
1,
537
]
],
[
[
1318,
24,
830
],
[
830,
1,
537
]
],
[
[
1318,
63,
13
],
[
13,
24,... | [
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Cyclizine (Compound)
Echothiophate may cause a moderate interaction tha... |
DB00166 | DB01309 | 333 | 1,254 | [
"DDInter1076",
"DDInter933"
] | Lipoic acid | Insulin glulisine | A vitamin-like antioxidant. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Minor | 0 | [
[
[
333,
23,
1254
]
],
[
[
333,
23,
1645
],
[
1645,
24,
1254
]
],
[
[
333,
23,
1645
],
[
1645,
62,
1103
],
[
1103,
23,
1254
]
],
[
[
333,
... | [
[
[
"Lipoic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Lipoic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metformin"
],
... | Lipoic acid may cause a minor interaction that can limit clinical effects when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Lipoic acid may cause a minor interaction that can limit clinical effects when taken with Metformin and Metf... |
DB00748 | DB01174 | 662 | 697 | [
"DDInter297",
"DDInter1442"
] | Carbinoxamine | Phenobarbital | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
662,
24,
697
]
],
[
[
662,
24,
759
],
[
759,
1,
697
]
],
[
[
662,
63,
362
],
[
362,
1,
697
]
],
[
[
662,
63,
536
],
[
536,
40,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Co... |
DB00321 | DB12010 | 21 | 214 | [
"DDInter78",
"DDInter785"
] | Amitriptyline | Fostamatinib | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
21,
24,
214
]
],
[
[
21,
24,
51
],
[
51,
24,
214
]
],
[
[
21,
63,
600
],
[
600,
24,
214
]
],
[
[
21,
25,
222
],
[
222,
24,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Fluconazo... |
DB00377 | DB11718 | 1,494 | 927 | [
"DDInter1382",
"DDInter640"
] | Palonosetron | Encorafenib | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1494,
24,
927
]
],
[
[
1494,
23,
112
],
[
112,
23,
927
]
],
[
[
1494,
24,
720
],
[
720,
24,
927
]
],
[
[
1494,
25,
946
],
[
946,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil an... |
DB00283 | DB00835 | 701 | 100 | [
"DDInter395",
"DDInter245"
] | Clemastine | Brompheniramine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
701,
24,
100
]
],
[
[
701,
24,
832
],
[
832,
24,
100
]
],
[
[
701,
24,
649
],
[
649,
63,
100
]
],
[
[
701,
35,
1594
],
[
1594,
2... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clofedan... |
DB09118 | DB11703 | 1,580 | 405 | [
"DDInter1711",
"DDInter9"
] | Stiripentol | Acalabrutinib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1580,
25,
405
]
],
[
[
1580,
63,
1051
],
[
1051,
24,
405
]
],
[
[
1580,
25,
982
],
[
982,
63,
405
]
],
[
[
1580,
24,
1320
],
[
1320,
... | [
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Stiripentol may lead to a major life threatening interaction when taken with Ivosidenib and Iv... |
DB00549 | DB09118 | 522 | 1,580 | [
"DDInter1955",
"DDInter1711"
] | Zafirlukast | Stiripentol | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
522,
24,
1580
]
],
[
[
522,
63,
168
],
[
168,
24,
1580
]
],
[
[
522,
24,
473
],
[
473,
24,
1580
]
],
[
[
522,
24,
985
],
[
985,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Re... |
DB00582 | DB12015 | 1,622 | 1,033 | [
"DDInter1946",
"DDInter53"
] | Voriconazole | Alpelisib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1622,
24,
1033
]
],
[
[
1622,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
1622,
24,
1144
],
[
1144,
24,
1033
]
],
[
[
1622,
25,
951
],
[
951... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxego... | Voriconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause... |
DB00569 | DB06186 | 553 | 1,439 | [
"DDInter775",
"DDInter969"
] | Fondaparinux | Ipilimumab | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Major | 2 | [
[
[
553,
25,
1439
]
],
[
[
553,
24,
1412
],
[
1412,
63,
1439
]
],
[
[
553,
63,
1560
],
[
1560,
24,
1439
]
],
[
[
553,
25,
1468
],
[
1468,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ipilimumab"
]
],
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
],
[
... | Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and Calaspargase pegol may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with P... |
DB00912 | DB13874 | 473 | 1,501 | [
"DDInter1581",
"DDInter639"
] | Repaglinide | Enasidenib | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
473,
24,
1501
]
],
[
[
473,
24,
1619
],
[
1619,
24,
1501
]
],
[
[
473,
63,
1419
],
[
1419,
24,
1501
]
],
[
[
473,
25,
255
],
[
255,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib... |
DB00207 | DB11986 | 1,570 | 484 | [
"DDInter157",
"DDInter648"
] | Azithromycin | Entrectinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1570,
24,
484
]
],
[
[
1570,
23,
112
],
[
112,
23,
484
]
],
[
[
1570,
24,
774
],
[
774,
24,
484
]
],
[
[
1570,
24,
1619
],
[
1619,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and ... |
DB00712 | DB11921 | 1,274 | 1,019 | [
"DDInter763",
"DDInter492"
] | Flurbiprofen | Deflazacort | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1274,
24,
1019
]
],
[
[
1274,
63,
443
],
[
443,
24,
1019
]
],
[
[
1274,
24,
959
],
[
959,
24,
1019
]
],
[
[
1274,
24,
1619
],
[
1619,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
],... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Glipizid... |
DB06414 | DB12010 | 655 | 214 | [
"DDInter703",
"DDInter785"
] | Etravirine | Fostamatinib | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
655,
24,
214
]
],
[
[
655,
24,
976
],
[
976,
24,
214
]
],
[
[
655,
63,
723
],
[
723,
24,
214
]
],
[
[
655,
64,
866
],
[
866,
24,... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Ap... |
DB01005 | DB10795 | 995 | 221 | [
"DDInter894",
"DDInter1486"
] | Hydroxyurea | Poliovirus type 1 antigen (formaldehyde inactivated) | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
995,
24,
221
]
],
[
[
995,
64,
581
],
[
581,
24,
221
]
],
[
[
995,
63,
599
],
[
599,
24,
221
]
],
[
[
995,
24,
1531
],
[
1531,
2... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Hydroxyurea",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Hydroxyurea may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when tak... |
DB00197 | DB08895 | 1,324 | 976 | [
"DDInter1881",
"DDInter1825"
] | Troglitazone | Tofacitinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1324,
24,
976
]
],
[
[
1324,
24,
307
],
[
307,
23,
976
]
],
[
[
1324,
24,
214
],
[
214,
63,
976
]
],
[
[
1324,
24,
723
],
[
723,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fos... |
DB00200 | DB09293 | 204 | 116 | [
"DDInter891",
"DDInter954"
] | Hydroxocobalamin | Iodide I-131 | Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
204,
24,
116
]
],
[
[
204,
21,
28741
],
[
28741,
60,
1413
],
[
1413,
24,
116
]
],
[
[
204,
21,
29223
],
[
29223,
60,
33
],
[
33,
25,... | [
[
[
"Hydroxocobalamin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Hydroxocobalamin",
"{u} (Compound) causes {v} (Side Effect)",
"Agitation"
],
[
"Agitation",
"{u} (Side E... | Hydroxocobalamin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Fexofenadine (Compound) and Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Hydroxocobalamin (Compound) causes Pleural effusion (Side Effect) and Pleural effusion... |
DB00781 | DB09133 | 1,481 | 1,527 | [
"DDInter1489",
"DDInter965"
] | Polymyxin B | Iothalamic acid | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
1481,
25,
1527
]
],
[
[
1481,
24,
242
],
[
242,
63,
1527
]
],
[
[
1481,
63,
91
],
[
91,
25,
1527
]
],
[
[
1481,
25,
416
],
[
416,
... | [
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Polymyxin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
[
"Rem... | Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and... |
DB01227 | DB08899 | 1,301 | 129 | [
"DDInter1043",
"DDInter649"
] | Levacetylmethadol | Enzalutamide | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1301,
25,
129
]
],
[
[
1301,
64,
918
],
[
918,
1,
129
]
],
[
[
1301,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1301,
62,
112
],
[
112,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalut... | Levacetylmethadol may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Levacetylmethadol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Levacetylmethadol may cause a minor interaction that can li... |
DB01218 | DB01238 | 1,493 | 673 | [
"DDInter852",
"DDInter118"
] | Halofantrine | Aripiprazole | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
1493,
24,
673
]
],
[
[
1493,
64,
851
],
[
851,
1,
673
]
],
[
[
1493,
64,
827
],
[
827,
40,
673
]
],
[
[
1493,
6,
3958
],
[
3958,
... | [
[
[
"Halofantrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
],
[
"Nefa... | Halofantrine may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Halofantrine may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Halofantrine (Compound) ... |
DB00531 | DB01181 | 450 | 1,532 | [
"DDInter456",
"DDInter906"
] | Cyclophosphamide | Ifosfamide | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
450,
35,
1532
]
],
[
[
450,
6,
8717
],
[
8717,
45,
1532
]
],
[
[
450,
18,
17480
],
[
17480,
57,
1532
]
],
[
[
450,
21,
28956
],
[
2895... | [
[
[
"Cyclophosphamide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
... | Cyclophosphamide (Compound) resembles Ifosfamide (Compound) and
Cyclophosphamide (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Ifosfamide (Compound)
Cyclophosphamide (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Ifosfamide (Compound)
Cyclophosphamide (Compound) causes Palpi... |
DB00092 | DB01206 | 58 | 37 | [
"DDInter40",
"DDInter1086"
] | Alefacept | Lomustine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
58,
24,
37
]
],
[
[
58,
24,
697
],
[
697,
23,
37
]
],
[
[
58,
24,
141
],
[
141,
24,
37
]
],
[
[
58,
24,
259
],
[
259,
63,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital may cause a minor interaction that can limit clinical effects when taken with Lomustine
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Flox... |
DB09075 | DB13148 | 498 | 1,566 | [
"DDInter621",
"DDInter422"
] | Edoxaban | Coagulation factor X human | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. However its use is limited in the perioperative setting for the management of bleeding in major surgery in patients with moderate and severe here... | Moderate | 1 | [
[
[
498,
24,
1566
]
],
[
[
498,
64,
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],
[
1409,
24,
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[
[
498,
25,
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],
[
1421,
24,
1566
]
],
[
[
498,
64,
1409
],
[
1409,
... | [
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Coagulation factor X human"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[
"... | Edoxaban may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Coagulation factor X human
Edoxaban may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moder... |
DB01579 | DB09080 | 341 | 144 | [
"DDInter1439",
"DDInter1331"
] | Phendimetrazine | Olodaterol | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
341,
24,
144
]
],
[
[
341,
63,
1445
],
[
1445,
24,
144
]
],
[
[
341,
64,
121
],
[
121,
24,
144
]
],
[
[
341,
24,
468
],
[
468,
2... | [
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Phendimetrazine may lead to a major life threatening interaction when taken with Fenfluramine and... |
DB00261 | DB00843 | 702 | 479 | [
"DDInter93",
"DDInter583"
] | Anagrelide | Donepezil | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
702,
24,
479
]
],
[
[
702,
25,
843
],
[
843,
1,
479
]
],
[
[
702,
7,
7095
],
[
7095,
57,
479
]
],
[
[
702,
18,
2183
],
[
2183,
5... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetrabenazine"
],
[
"Tetraben... | Anagrelide may lead to a major life threatening interaction when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Anagrelide (Compound) upregulates CCL2 (Gene) and CCL2 (Gene) is downregulated by Donepezil (Compound)
Anagrelide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) i... |
DB01177 | DB08867 | 77 | 807 | [
"DDInter904",
"DDInter1897"
] | Idarubicin | Ulipristal | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Moderate | 1 | [
[
[
77,
24,
807
]
],
[
[
77,
63,
600
],
[
600,
23,
807
]
],
[
[
77,
24,
609
],
[
609,
23,
807
]
],
[
[
77,
25,
478
],
[
478,
24,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Cl... |
DB00477 | DB01132 | 216 | 1,130 | [
"DDInter363",
"DDInter1472"
] | Chlorpromazine | Pioglitazone | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
216,
24,
1130
]
],
[
[
216,
6,
12523
],
[
12523,
45,
1130
]
],
[
[
216,
7,
4789
],
[
4789,
45,
1130
]
],
[
[
216,
21,
28778
],
[
28778... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (C... | Chlorpromazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pioglitazone (Compound)
Chlorpromazine (Compound) upregulates PPARG (Gene) and PPARG (Gene) is bound by Pioglitazone (Compound)
Chlorpromazine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by ... |
DB00682 | DB00749 | 126 | 59 | [
"DDInter1951",
"DDInter699"
] | Warfarin | Etodolac | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Major | 2 | [
[
[
126,
25,
59
]
],
[
[
126,
6,
6017
],
[
6017,
45,
59
]
],
[
[
126,
24,
1194
],
[
1194,
62,
59
]
],
[
[
126,
63,
752
],
[
752,
23,... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etodolac"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Etodolac"
... | Warfarin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etodolac (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Etodolac
Warfarin may cause a moderat... |
DB05773 | DB11932 | 1,047 | 327 | [
"DDInter1848",
"DDInter3"
] | Trastuzumab emtansine | Abametapir (topical) | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1047,
24,
327
]
],
[
[
1047,
63,
168
],
[
168,
24,
327
]
],
[
[
1047,
25,
292
],
[
292,
24,
327
]
],
[
[
1047,
24,
310
],
[
310,
... | [
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Borte... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01165 | DB01166 | 1,539 | 477 | [
"DDInter1325",
"DDInter379"
] | Ofloxacin | Cilostazol | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1539,
24,
477
]
],
[
[
1539,
6,
7950
],
[
7950,
45,
477
]
],
[
[
1539,
18,
9384
],
[
9384,
57,
477
]
],
[
[
1539,
21,
28919
],
[
28919... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Ofloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Ofloxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cilostazol (Compound)
Ofloxacin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Cilostazol (Compound)
Ofloxacin (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Oflox... |
DB06605 | DB12010 | 1,409 | 214 | [
"DDInter108",
"DDInter785"
] | Apixaban | Fostamatinib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1409,
24,
214
]
],
[
[
1409,
63,
723
],
[
723,
24,
214
]
],
[
[
1409,
62,
307
],
[
307,
24,
214
]
],
[
[
1409,
24,
179
],
[
179,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Apixaban may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil m... |
DB00317 | DB12010 | 883 | 214 | [
"DDInter810",
"DDInter785"
] | Gefitinib | Fostamatinib | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
883,
24,
214
]
],
[
[
883,
24,
723
],
[
723,
24,
214
]
],
[
[
883,
1,
924
],
[
924,
24,
214
]
],
[
[
883,
23,
307
],
[
307,
24,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Gefitinib (Compound) resembles Iloperidone (Compound) and Iloperidone may cause a moderate interaction that cou... |
DB00060 | DB00649 | 912 | 231 | [
"DDInter947",
"DDInter1710"
] | Interferon beta-1a | Stavudine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Moderate | 1 | [
[
[
912,
24,
231
]
],
[
[
912,
25,
139
],
[
139,
1,
231
]
],
[
[
912,
24,
1555
],
[
1555,
24,
231
]
],
[
[
912,
24,
14
],
[
14,
63,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stavudine"
]
],
[
[
"Interferon beta-1a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
... | Interferon beta-1a may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine (Compound) resembles Stavudine (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that cou... |
DB00637 | DB09330 | 1,557 | 985 | [
"DDInter128",
"DDInter1352"
] | Astemizole | Osimertinib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1557,
24,
985
]
],
[
[
1557,
23,
1247
],
[
1247,
23,
985
]
],
[
[
1557,
24,
1478
],
[
1478,
24,
985
]
],
[
[
1557,
24,
1598
],
[
1598,... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor an... |
DB00543 | DB01001 | 87 | 688 | [
"DDInter82",
"DDInter1632"
] | Amoxapine | Salbutamol | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
87,
24,
688
]
],
[
[
87,
25,
874
],
[
874,
24,
688
]
],
[
[
87,
24,
455
],
[
455,
24,
688
]
],
[
[
87,
64,
1636
],
[
1636,
24,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Epinephrine... | Amoxapine may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause ... |
DB01132 | DB01404 | 1,130 | 757 | [
"DDInter1472",
"DDInter820"
] | Pioglitazone | Ginseng | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1130,
24,
757
]
],
[
[
1130,
63,
473
],
[
473,
24,
757
]
],
[
[
1130,
64,
1347
],
[
1347,
24,
757
]
],
[
[
1130,
24,
1254
],
[
1254,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
[
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Pioglitazone may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may c... |
DB11186 | DB14509 | 1,609 | 1,399 | [
"DDInter1427",
"DDInter1081"
] | Pentoxyverine | Lithium carbonate | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant, and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists. Pentoxyverine acts on sigma-1... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1609,
24,
1399
]
],
[
[
1609,
63,
506
],
[
506,
24,
1399
]
],
[
[
1609,
63,
222
],
[
222,
25,
1399
]
],
[
[
1609,
63,
506
],
[
506,
... | [
[
[
"Pentoxyverine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Pentoxyverine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorph... | Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00470 | DB00656 | 530 | 827 | [
"DDInter601",
"DDInter1851"
] | Dronabinol | Trazodone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Moderate | 1 | [
[
[
530,
24,
827
]
],
[
[
530,
24,
623
],
[
623,
40,
827
]
],
[
[
530,
24,
1630
],
[
1630,
1,
827
]
],
[
[
530,
63,
1408
],
[
1408,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compound... |
DB00431 | DB09128 | 1,503 | 1,241 | [
"DDInter1072",
"DDInter231"
] | Lindane | Brexpiprazole | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
1503,
24,
1241
]
],
[
[
1503,
24,
129
],
[
129,
24,
1241
]
],
[
[
1503,
24,
407
],
[
407,
63,
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]
],
[
[
1503,
63,
999
],
[
999,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may ... |
DB00590 | DB09065 | 1,433 | 760 | [
"DDInter592",
"DDInter424"
] | Doxazosin | Cobicistat | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1433,
24,
760
]
],
[
[
1433,
40,
479
],
[
479,
23,
760
]
],
[
[
1433,
24,
609
],
[
609,
24,
760
]
],
[
[
1433,
63,
251
],
[
251,
... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Doxazosin",
"{u} (Compound) resembles {v} (Compound)",
"Donepezil"
],
[
"Donepezil",
"{u} may cause a minor inter... | Doxazosin (Compound) resembles Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that cou... |
DB00748 | DB04946 | 662 | 924 | [
"DDInter297",
"DDInter907"
] | Carbinoxamine | Iloperidone | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
662,
24,
924
]
],
[
[
662,
63,
1664
],
[
1664,
1,
924
]
],
[
[
662,
24,
519
],
[
519,
40,
924
]
],
[
[
662,
6,
10104
],
[
10104,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperido... |
DB00295 | DB00395 | 475 | 210 | [
"DDInter1244",
"DDInter301"
] | Morphine | Carisoprodol | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with ... | Major | 2 | [
[
[
475,
25,
210
]
],
[
[
475,
25,
1050
],
[
1050,
40,
210
]
],
[
[
475,
21,
28757
],
[
28757,
60,
210
]
],
[
[
475,
24,
1637
],
[
1637,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carisoprodol"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meprobamate"
],
[
"Meprobamate",
"{u} (... | Morphine may lead to a major life threatening interaction when taken with Meprobamate and Meprobamate (Compound) resembles Carisoprodol (Compound)
Morphine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carisoprodol (Compound)
Morphine may cause a moderate interaction that could exac... |
DB00029 | DB00476 | 25 | 109 | [
"DDInter99",
"DDInter608"
] | Anistreplase | Duloxetine | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
25,
24,
109
]
],
[
[
25,
24,
758
],
[
758,
1,
109
]
],
[
[
25,
25,
1409
],
[
1409,
63,
109
]
],
[
[
25,
24,
477
],
[
477,
63,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Anistreplase may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate dis... |
DB00363 | DB01229 | 695 | 973 | [
"DDInter419",
"DDInter1378"
] | Clozapine | Paclitaxel (protein-bound) | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Major | 2 | [
[
[
695,
25,
973
]
],
[
[
695,
25,
310
],
[
310,
63,
973
]
],
[
[
695,
6,
8374
],
[
8374,
45,
973
]
],
[
[
695,
7,
16703
],
[
16703,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel",
"{u} m... | Clozapine may lead to a major life threatening interaction when taken with Paclitaxel
Clozapine may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Clozapine (Compound) binds CYP3A4 (Gene)... |
DB01129 | DB06589 | 379 | 1,250 | [
"DDInter1559",
"DDInter1400"
] | Rabeprazole | Pazopanib | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
379,
25,
1250
]
],
[
[
379,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
379,
21,
28868
],
[
28868,
60,
1250
]
],
[
[
379,
63,
307
],
[
307,
... | [
[
[
"Rabeprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Rabeprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Pazopa... | Rabeprazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Rabeprazole (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Pazopanib (Compound)
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Mo... |
DB00358 | DB01056 | 1,010 | 571 | [
"DDInter1140",
"DDInter1823"
] | Mefloquine | Tocainide | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. | Moderate | 1 | [
[
[
1010,
24,
571
]
],
[
[
1010,
24,
143
],
[
143,
1,
571
]
],
[
[
1010,
63,
608
],
[
608,
35,
571
]
],
[
[
1010,
24,
143
],
[
143,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocainide"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mexiletine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Mexiletine and Mexiletine (Compound) resembles Tocainide (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine (Compound) resembles Tocainide (Compound) and ... |
DB00046 | DB00636 | 1,179 | 429 | [
"DDInter940",
"DDInter408"
] | Insulin lispro | Clofibrate | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) | Moderate | 1 | [
[
[
1179,
24,
429
]
],
[
[
1179,
24,
535
],
[
535,
40,
429
]
],
[
[
1179,
24,
1411
],
[
1411,
63,
429
]
],
[
[
1179,
24,
245
],
[
245,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofibrate"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibrate"
],... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Fenofibrate and Fenofibrate (Compound) resembles Clofibrate (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interactio... |
DB01197 | DB08938 | 1,603 | 1,384 | [
"DDInter292",
"DDInter1112"
] | Captopril | Magaldrate | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
1603,
23,
1384
]
],
[
[
1603,
63,
167
],
[
167,
23,
1384
]
],
[
[
1603,
24,
1220
],
[
1220,
23,
1384
]
],
[
[
1603,
40,
610
],
[
610,
... | [
[
[
"Captopril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and... |
DB05812 | DB15093 | 1,374 | 1,654 | [
"DDInter8",
"DDInter1698"
] | Abiraterone | Somapacitan | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1374,
24,
1654
]
],
[
[
1374,
23,
1135
],
[
1135,
24,
1654
]
],
[
[
1374,
25,
351
],
[
351,
24,
1654
]
],
[
[
1374,
63,
1512
],
[
1512... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Abiraterone may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a... |
DB06626 | DB11730 | 263 | 351 | [
"DDInter147",
"DDInter1588"
] | Axitinib | Ribociclib | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
263,
24,
351
]
],
[
[
263,
24,
283
],
[
283,
62,
351
]
],
[
[
263,
24,
1627
],
[
1627,
23,
351
]
],
[
[
263,
63,
288
],
[
288,
2... | [
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol... |
DB00206 | DB01143 | 1,245 | 923 | [
"DDInter1582",
"DDInter65"
] | Reserpine | Amifostine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1245,
24,
923
]
],
[
[
1245,
21,
28642
],
[
28642,
60,
923
]
],
[
[
1245,
24,
714
],
[
714,
24,
923
]
],
[
[
1245,
40,
1340
],
[
1340,... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Reserpine",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v} ... | Reserpine (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Reserpine ... |
DB00501 | DB01238 | 752 | 673 | [
"DDInter380",
"DDInter118"
] | Cimetidine | Aripiprazole | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
752,
24,
673
]
],
[
[
752,
6,
21998
],
[
21998,
45,
673
]
],
[
[
752,
21,
29377
],
[
29377,
60,
673
]
],
[
[
752,
23,
112
],
[
112,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound... | Cimetidine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Aripiprazole (Compound)
Cimetidine (Compound) causes Musculoskeletal pain (Side Effect) and Musculoskeletal pain (Side Effect) is caused by Aripiprazole (Compound)
Cimetidine may cause a minor interaction that can limit clinical e... |
DB00501 | DB11730 | 752 | 351 | [
"DDInter380",
"DDInter1588"
] | Cimetidine | Ribociclib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
752,
24,
351
]
],
[
[
752,
23,
271
],
[
271,
23,
351
]
],
[
[
752,
23,
466
],
[
466,
62,
351
]
],
[
[
752,
24,
283
],
[
283,
62,... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutami... |
DB00678 | DB09038 | 240 | 1,450 | [
"DDInter1095",
"DDInter636"
] | Losartan | Empagliflozin | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
240,
24,
1450
]
],
[
[
240,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
240,
1,
911
],
[
911,
24,
1450
]
],
[
[
240,
24,
1486
],
[
1486,
... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Losartan may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Losartan (Compound) resembles Azilsartan medoxomil (Compound) and Azilsartan medoxomil may cause a moderate... |
DB00867 | DB06335 | 1,052 | 761 | [
"DDInter1606",
"DDInter1646"
] | Ritodrine | Saxagliptin | Adrenergic beta-agonist used to control premature labor. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1052,
24,
761
]
],
[
[
1052,
24,
1491
],
[
1491,
63,
761
]
],
[
[
1052,
62,
1573
],
[
1573,
24,
761
]
],
[
[
1052,
63,
1445
],
[
1445,... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Ritodrine may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednis... |
DB00381 | DB01041 | 376 | 770 | [
"DDInter79",
"DDInter1789"
] | Amlodipine | Thalidomide | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
376,
24,
770
]
],
[
[
376,
6,
7524
],
[
7524,
45,
770
]
],
[
[
376,
7,
7669
],
[
7669,
46,
770
]
],
[
[
376,
7,
9384
],
[
9384,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)"... | Amlodipine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Amlodipine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Amlodipine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Thalidomide (Compound)
Amlodipine (C... |
DB00286 | DB08820 | 380 | 1,478 | [
"DDInter439",
"DDInter997"
] | Conjugated estrogens | Ivacaftor | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
380,
24,
1478
]
],
[
[
380,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
380,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
380,
24,
1411
],
[
1411,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound ... | Conjugated estrogens (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Conjugated estrogens (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases whe... |
DB00078 | DB08880 | 1,172 | 1,510 | [
"DDInter898",
"DDInter1771"
] | Ibritumomab tiuxetan | Teriflunomide | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1172,
25,
1510
]
],
[
[
1172,
24,
221
],
[
221,
63,
1510
]
],
[
[
1172,
24,
1136
],
[
1136,
24,
1510
]
],
[
[
1172,
25,
1061
],
[
1061... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 a... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Ibritumomab tiu... |
DB00092 | DB00741 | 58 | 167 | [
"DDInter40",
"DDInter885"
] | Alefacept | Hydrocortisone | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
58,
24,
167
]
],
[
[
58,
24,
1220
],
[
1220,
40,
167
]
],
[
[
58,
24,
870
],
[
870,
1,
167
]
],
[
[
58,
23,
1193
],
[
1193,
62,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydr... |
DB00434 | DB01591 | 13 | 667 | [
"DDInter459",
"DDInter1696"
] | Cyproheptadine | Solifenacin | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
13,
24,
667
]
],
[
[
13,
6,
7992
],
[
7992,
45,
667
]
],
[
[
13,
21,
28786
],
[
28786,
60,
667
]
],
[
[
13,
24,
830
],
[
830,
63... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Comp... | Cyproheptadine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Solifenacin (Compound)
Cyproheptadine (Compound) causes Urinary retention (Side Effect) and Urinary retention (Side Effect) is caused by Solifenacin (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00655 | DB04868 | 559 | 478 | [
"DDInter682",
"DDInter1293"
] | Estrone | Nilotinib | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
559,
24,
478
]
],
[
[
559,
6,
6017
],
[
6017,
45,
478
]
],
[
[
559,
18,
10375
],
[
10375,
57,
478
]
],
[
[
559,
21,
28762
],
[
28762,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Estrone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Estrone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Estrone (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Nilotinib (Compound)
Estrone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nilotinib (Compound)
Estrone may ca... |
DB00247 | DB00549 | 1,131 | 522 | [
"DDInter1194",
"DDInter1955"
] | Methysergide | Zafirlukast | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
1131,
24,
522
]
],
[
[
1131,
21,
28698
],
[
28698,
60,
522
]
],
[
[
1131,
24,
222
],
[
222,
62,
522
]
],
[
[
1131,
24,
1362
],
[
1362,... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Methysergide",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is c... | Methysergide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Zafirlukast (Compound)
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Zafi... |
DB00486 | DB04946 | 1,614 | 924 | [
"DDInter1253",
"DDInter907"
] | Nabilone | Iloperidone | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
1614,
24,
924
]
],
[
[
1614,
24,
1664
],
[
1664,
1,
924
]
],
[
[
1614,
24,
519
],
[
519,
40,
924
]
],
[
[
1614,
21,
28809
],
[
28809,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone (Compou... |
DB11915 | DB12332 | 1,293 | 1,619 | [
"DDInter1909",
"DDInter1626"
] | Valbenazine | Rucaparib | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1293,
24,
1619
]
],
[
[
1293,
63,
222
],
[
222,
23,
1619
]
],
[
[
1293,
62,
112
],
[
112,
23,
1619
]
],
[
[
1293,
63,
1662
],
[
1662,
... | [
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Valbenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metr... |
DB00880 | DB00938 | 359 | 455 | [
"DDInter360",
"DDInter1635"
] | Chlorothiazide | Salmeterol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
359,
24,
455
]
],
[
[
359,
24,
688
],
[
688,
63,
455
]
],
[
[
359,
21,
28722
],
[
28722,
60,
455
]
],
[
[
359,
63,
167
],
[
167,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Chlorothiazide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Salmeterol (Comp... |
DB04865 | DB14962 | 4 | 1,363 | [
"DDInter1335",
"DDInter1847"
] | Omacetaxine mepesuccinate | Trastuzumab deruxtecan | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes i... | Moderate | 1 | [
[
[
4,
24,
1363
]
],
[
[
4,
24,
1430
],
[
1430,
24,
1363
]
],
[
[
4,
63,
1253
],
[
1253,
24,
1363
]
],
[
[
4,
25,
507
],
[
507,
25,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab deruxtecan"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab deruxtecan
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate ... |
DB00081 | DB06779 | 273 | 365 | [
"DDInter1838",
"DDInter470"
] | Tositumomab | Dalteparin | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
273,
25,
365
]
],
[
[
273,
23,
539
],
[
539,
62,
365
]
],
[
[
273,
24,
1100
],
[
1100,
24,
365
]
],
[
[
273,
24,
1427
],
[
1427,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Tositumomab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Tositumomab may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine... |
DB00586 | DB00877 | 1,512 | 629 | [
"DDInter537",
"DDInter1678"
] | Diclofenac | Sirolimus | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
1512,
25,
629
]
],
[
[
1512,
6,
4973
],
[
4973,
45,
629
]
],
[
[
1512,
18,
5660
],
[
5660,
46,
629
]
],
[
[
1512,
18,
2801
],
[
2801,
... | [
[
[
"Diclofenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Sirolimus"... | Diclofenac (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Diclofenac (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is upregulated by Sirolimus (Compound)
Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Sirolimus (Compound)
Diclofenac (Compo... |
DB00397 | DB09068 | 1,466 | 1,427 | [
"DDInter1458",
"DDInter1948"
] | Phenylpropanolamine | Vortioxetine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
1466,
25,
1427
]
],
[
[
1466,
63,
1685
],
[
1685,
24,
1427
]
],
[
[
1466,
24,
959
],
[
959,
24,
1427
]
],
[
[
1466,
24,
1383
],
[
1383... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin human"
],
... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00552 | DB00685 | 1,238 | 1,299 | [
"DDInter1425",
"DDInter1887"
] | Pentostatin | Trovafloxacin | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Minor | 0 | [
[
[
1238,
23,
1299
]
],
[
[
1238,
23,
872
],
[
872,
40,
1299
]
],
[
[
1238,
62,
1467
],
[
1467,
40,
1299
]
],
[
[
1238,
21,
29093
],
[
290... | [
[
[
"Pentostatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Pentostatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
[... | Pentostatin may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Pentostatin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Trovafloxacin (Compou... |
DB01035 | DB06595 | 1,401 | 1,491 | [
"DDInter1524",
"DDInter1214"
] | Procainamide | Midostaurin | A derivative of procaine with less CNS action. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
1401,
25,
1491
]
],
[
[
1401,
62,
112
],
[
112,
23,
1491
]
],
[
[
1401,
64,
888
],
[
888,
24,
1491
]
],
[
[
1401,
63,
58
],
[
58,
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Procainamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Procainamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Procainamide may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may c... |
DB00834 | DB01041 | 932 | 770 | [
"DDInter1215",
"DDInter1789"
] | Mifepristone | Thalidomide | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
932,
24,
770
]
],
[
[
932,
6,
7524
],
[
7524,
45,
770
]
],
[
[
932,
7,
7669
],
[
7669,
46,
770
]
],
[
[
932,
21,
28714
],
[
28714,
... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compou... | Mifepristone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Mifepristone (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Mifepristone (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Thalidomide (Compound)... |
DB00773 | DB12010 | 896 | 214 | [
"DDInter702",
"DDInter785"
] | Etoposide | Fostamatinib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
896,
24,
214
]
],
[
[
896,
25,
976
],
[
976,
24,
214
]
],
[
[
896,
63,
723
],
[
723,
24,
214
]
],
[
[
896,
24,
973
],
[
973,
24,... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitin... | Etoposide may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may caus... |
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