drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01181 | DB11901 | 1,532 | 913 | [
"DDInter906",
"DDInter107"
] | Ifosfamide | Apalutamide | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1532,
24,
913
]
],
[
[
1532,
63,
279
],
[
279,
24,
913
]
],
[
[
1532,
24,
1237
],
[
1237,
24,
913
]
],
[
[
1532,
23,
255
],
[
255,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and C... |
DB00344 | DB01069 | 1,302 | 401 | [
"DDInter1543",
"DDInter1533"
] | Protriptyline | Promethazine | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1302,
24,
401
]
],
[
[
1302,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1302,
40,
1506
],
[
1506,
40,
401
]
],
[
[
1302,
1,
1405
],
[
1405,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Protriptyline (Compound) resembles Desipramine (Compound) and Desipramine (Compound) resembles Promethazine (Comp... |
DB00060 | DB00550 | 912 | 99 | [
"DDInter947",
"DDInter1541"
] | Interferon beta-1a | Propylthiouracil | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Moderate | 1 | [
[
[
912,
24,
99
]
],
[
[
912,
24,
372
],
[
372,
63,
99
]
],
[
[
912,
24,
482
],
[
482,
24,
99
]
],
[
[
912,
63,
305
],
[
305,
24,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propylthiouracil"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofa... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00470 | DB01452 | 530 | 993 | [
"DDInter601",
"DDInter532"
] | Dronabinol | Diamorphine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Moderate | 1 | [
[
[
530,
24,
993
]
],
[
[
530,
63,
421
],
[
421,
40,
993
]
],
[
[
530,
63,
475
],
[
475,
25,
993
]
],
[
[
530,
24,
1637
],
[
1637,
6... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diamorphine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Diamorphine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening int... |
DB00477 | DB04868 | 216 | 478 | [
"DDInter363",
"DDInter1293"
] | Chlorpromazine | Nilotinib | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
216,
25,
478
]
],
[
[
216,
6,
4973
],
[
4973,
45,
478
]
],
[
[
216,
7,
2703
],
[
2703,
46,
478
]
],
[
[
216,
18,
1918
],
[
1918,
... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Ni... | Chlorpromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Chlorpromazine (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Nilotinib (Compound)
Chlorpromazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Nilotinib (Compound)
Chlorprom... |
DB00332 | DB01057 | 1,089 | 1,318 | [
"DDInter970",
"DDInter615"
] | Ipratropium | Echothiophate (ophthalmic) | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | Moderate | 1 | [
[
[
1089,
24,
1318
]
],
[
[
1089,
21,
28817
],
[
28817,
60,
1318
]
],
[
[
1089,
24,
830
],
[
830,
63,
1318
]
],
[
[
1089,
24,
1219
],
[
12... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Echothiophate"
]
],
[
[
"Ipratropium",
"{u} (Compound) causes {v} (Side Effect)",
"Vision blurred"
],
[
"Vision blurred",
"{u} (Side ... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Echothiophate
Ipratropium (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Echothiophate (Compound)
Ipratropium may cause a moderate interaction that could exacerbate diseases when tak... |
DB00635 | DB10276 | 1,573 | 1,624 | [
"DDInter1515",
"DDInter1623"
] | Prednisone | Rotavirus vaccine | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1573,
25,
1624
]
],
[
[
1573,
1,
617
],
[
617,
24,
1624
]
],
[
[
1573,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
1573,
25,
770
],
[
770,
... | [
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound)",
"Budesonide"
],
[
"Budesonide",
"{u} may cause a moderate intera... | Prednisone (Compound) resembles Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may lead to a major life threateni... |
DB01087 | DB01611 | 1,520 | 1,487 | [
"DDInter1520",
"DDInter893"
] | Primaquine | Hydroxychloroquine | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1520,
25,
1487
]
],
[
[
1520,
1,
1157
],
[
1157,
40,
1487
]
],
[
[
1520,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1520,
21,
28658
],
[
2... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Primaquine",
"{u} (Compound) resembles {v} (Compound)",
"Chloroquine"
],
[
"Chloroquine",
"{u} (Compound) resembles {v}... | Primaquine (Compound) resembles Chloroquine (Compound) and Chloroquine (Compound) resembles Hydroxychloroquine (Compound)
Primaquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Primaquine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydr... |
DB00656 | DB09268 | 827 | 1,662 | [
"DDInter1851",
"DDInter1464"
] | Trazodone | Picosulfuric acid | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
827,
24,
1662
]
],
[
[
827,
24,
484
],
[
484,
63,
1662
]
],
[
[
827,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
827,
24,
1491
],
[
1491,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Trazodone may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib... |
DB00731 | DB00880 | 1,144 | 359 | [
"DDInter1269",
"DDInter360"
] | Nateglinide | Chlorothiazide | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
1144,
24,
359
]
],
[
[
1144,
24,
1577
],
[
1577,
1,
359
]
],
[
[
1144,
63,
1014
],
[
1014,
1,
359
]
],
[
[
1144,
6,
10612
],
[
10612,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resemb... |
DB08880 | DB08913 | 1,510 | 1,186 | [
"DDInter1771",
"DDInter1561"
] | Teriflunomide | Radium Ra 223 dichloride | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1510,
24,
1186
]
],
[
[
1510,
64,
37
],
[
37,
24,
1186
]
],
[
[
1510,
25,
1583
],
[
1583,
63,
1186
]
],
[
[
1510,
25,
1468
],
[
1468,
... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomustine"
],
... | Teriflunomide may lead to a major life threatening interaction when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Teriflunomide may lead to a major life threatening interaction when taken with Sarilumab and Sarilumab may cause... |
DB00283 | DB00341 | 701 | 1,242 | [
"DDInter395",
"DDInter343"
] | Clemastine | Cetirizine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
701,
35,
1242
]
],
[
[
701,
40,
465
],
[
465,
1,
1242
]
],
[
[
701,
24,
537
],
[
537,
63,
1242
]
],
[
[
701,
1,
11268
],
[
11268,
... | [
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound)",
"Chlorcyclizine"
],
[
... | Clemastine (Compound) resembles Cetirizine (Compound) and
Clemastine (Compound) resembles Chlorcyclizine (Compound) and Chlorcyclizine (Compound) resembles Cetirizine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate intera... |
DB00682 | DB00959 | 126 | 1,486 | [
"DDInter1951",
"DDInter1191"
] | Warfarin | Methylprednisolone | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
126,
24,
1486
]
],
[
[
126,
24,
1581
],
[
1581,
1,
1486
]
],
[
[
126,
63,
175
],
[
175,
40,
1486
]
],
[
[
126,
24,
617
],
[
617,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testolactone"
],
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Testolactone and Testolactone (Compound) resembles Methylprednisolone (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylpr... |
DB00008 | DB01235 | 491 | 1,191 | [
"DDInter1407",
"DDInter1054"
] | Peginterferon alfa-2a | Levodopa | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
491,
24,
1191
]
],
[
[
491,
24,
63
],
[
63,
24,
1191
]
],
[
[
491,
24,
148
],
[
148,
63,
1191
]
],
[
[
491,
25,
1377
],
[
1377,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tenipos... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB01024 | DB09389 | 1,096 | 517 | [
"DDInter1252",
"DDInter1315"
] | Mycophenolic acid | Norgestrel | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Major | 2 | [
[
[
1096,
25,
517
]
],
[
[
1096,
64,
581
],
[
581,
24,
517
]
],
[
[
1096,
25,
908
],
[
908,
24,
517
]
],
[
[
1096,
24,
1017
],
[
1017,
... | [
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norgestrel"
]
],
[
[
"Mycophenolic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
"Infliximab"... | Mycophenolic acid may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Mycophenolic acid may lead to a major life threatening interaction when taken with Golimumab and Golimumab may cause a m... |
DB09263 | DB11248 | 1,436 | 1,193 | [
"DDInter1399",
"DDInter1965"
] | Patiromer | Zinc gluconate | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1436,
24,
1193
]
],
[
[
1436,
63,
1596
],
[
1596,
23,
1193
]
],
[
[
1436,
24,
1019
],
[
1019,
62,
1193
]
],
[
[
1436,
63,
1596
],
[
15... | [
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
[
... | Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may c... |
DB00563 | DB00713 | 663 | 1,138 | [
"DDInter1174",
"DDInter1354"
] | Methotrexate | Oxacillin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections. | Major | 2 | [
[
[
663,
25,
1138
]
],
[
[
663,
64,
916
],
[
916,
1,
1138
]
],
[
[
663,
25,
950
],
[
950,
1,
1138
]
],
[
[
663,
25,
1249
],
[
1249,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxacillin"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dicloxacillin"
],
[
"Dicloxacillin",
... | Methotrexate may lead to a major life threatening interaction when taken with Dicloxacillin and Dicloxacillin (Compound) resembles Oxacillin (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Cloxacillin and Cloxacillin (Compound) resembles Oxacillin (Compound)
Methotrexate may lea... |
DB01105 | DB01215 | 222 | 1,418 | [
"DDInter1665",
"DDInter677"
] | Sibutramine | Estazolam | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
222,
24,
1418
]
],
[
[
222,
63,
523
],
[
523,
1,
1418
]
],
[
[
222,
63,
1216
],
[
1216,
40,
1418
]
],
[
[
222,
64,
87
],
[
87,
4... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
... |
DB00572 | DB01142 | 85 | 1,264 | [
"DDInter136",
"DDInter593"
] | Atropine | Doxepin | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
85,
24,
1264
]
],
[
[
85,
63,
508
],
[
508,
24,
1264
]
],
[
[
85,
24,
401
],
[
401,
24,
1264
]
],
[
[
85,
24,
1405
],
[
1405,
25... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
"Pro... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine ... |
DB00333 | DB11767 | 576 | 1,583 | [
"DDInter1166",
"DDInter1643"
] | Methadone | Sarilumab | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
576,
24,
1583
]
],
[
[
576,
25,
267
],
[
267,
24,
1583
]
],
[
[
576,
1,
704
],
[
704,
24,
1583
]
],
[
[
576,
24,
1362
],
[
1362,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naltrexone"
],
[
"Naltrexone",
... | Methadone may lead to a major life threatening interaction when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Methadone (Compound) resembles Fentanyl (Compound) and Fentanyl may cause a moderate interaction that could exacerbate diseases w... |
DB00261 | DB00342 | 702 | 1,181 | [
"DDInter93",
"DDInter1770"
] | Anagrelide | Terfenadine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Major | 2 | [
[
[
702,
25,
1181
]
],
[
[
702,
23,
1247
],
[
1247,
62,
1181
]
],
[
[
702,
25,
252
],
[
252,
63,
1181
]
],
[
[
702,
24,
286
],
[
286,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Terfenadine"
]
],
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfa... | Anagrelide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Terfenadine
Anagrelide may lead to a major life threatening interaction when taken with Hydroxyzine and Hydroxyzine... |
DB00618 | DB00682 | 1,572 | 126 | [
"DDInter498",
"DDInter1951"
] | Demeclocycline | Warfarin | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
1572,
24,
126
]
],
[
[
1572,
62,
443
],
[
443,
23,
126
]
],
[
[
1572,
23,
359
],
[
359,
62,
126
]
],
[
[
1572,
63,
663
],
[
663,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Demeclocycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Spironolactone"
],
... | Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Spironolactone and Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazid... |
DB00047 | DB12015 | 176 | 1,033 | [
"DDInter932",
"DDInter53"
] | Insulin glargine | Alpelisib | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
176,
24,
1033
]
],
[
[
176,
24,
154
],
[
154,
24,
1033
]
],
[
[
176,
24,
1385
],
[
1385,
63,
1033
]
],
[
[
176,
25,
255
],
[
255,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutid... |
DB00014 | DB00816 | 521 | 1,674 | [
"DDInter839",
"DDInter1346"
] | Goserelin | Orciprenaline | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
521,
24,
1674
]
],
[
[
521,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
521,
24,
1164
],
[
1164,
24,
1674
]
],
[
[
521,
24,
959
],
[
959,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is cau... | Goserelin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Or... |
DB09381 | DB12267 | 192 | 1,476 | [
"DDInter678",
"DDInter233"
] | Esterified estrogens | Brigatinib | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
192,
24,
1476
]
],
[
[
192,
63,
176
],
[
176,
24,
1476
]
],
[
[
192,
24,
1385
],
[
1385,
63,
1476
]
],
[
[
192,
64,
1668
],
[
1668,
... | [
[
[
"Esterified estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Esterified estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin... | Esterified estrogens may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Esterified estrogens may cause a moderate interaction that could exacerbate diseases when ... |
DB00514 | DB00857 | 506 | 1,387 | [
"DDInter527",
"DDInter1768"
] | Dextromethorphan | Terbinafine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Major | 2 | [
[
[
506,
25,
1387
]
],
[
[
506,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
506,
7,
3727
],
[
3727,
46,
1387
]
],
[
[
506,
21,
28921
],
[
28921,
... | [
[
[
"Dextromethorphan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Terbinafine"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Dextromethorphan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Dextromethorphan (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Terbinafine (Compound)
Dextromethorphan (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Terbinafine ... |
DB00862 | DB09472 | 1,005 | 1,383 | [
"DDInter1918",
"DDInter1693"
] | Vardenafil | Sodium sulfate | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1005,
24,
1383
]
],
[
[
1005,
25,
609
],
[
609,
24,
1383
]
],
[
[
1005,
63,
521
],
[
521,
24,
1383
]
],
[
[
1005,
24,
1342
],
[
1342,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Cl... | Vardenafil may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin ... |
DB12500 | DB15328 | 283 | 829 | [
"DDInter714",
"DDInter1896"
] | Fedratinib | Ubrogepant | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
283,
24,
829
]
],
[
[
283,
64,
1476
],
[
1476,
24,
829
]
],
[
[
283,
63,
578
],
[
578,
24,
829
]
],
[
[
283,
62,
1593
],
[
1593,
... | [
[
[
"Fedratinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Fedratinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib... | Fedratinib may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause ... |
DB00549 | DB09276 | 522 | 381 | [
"DDInter1955",
"DDInter1682"
] | Zafirlukast | Sodium aurothiomalate | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
522,
24,
381
]
],
[
[
522,
63,
491
],
[
491,
24,
381
]
],
[
[
522,
24,
1047
],
[
1047,
24,
381
]
],
[
[
522,
24,
1480
],
[
1480,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon ... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Zafirlukast may cause a moderate interaction that could exacerbate diseases wh... |
DB00470 | DB08822 | 530 | 911 | [
"DDInter601",
"DDInter156"
] | Dronabinol | Azilsartan medoxomil | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
530,
24,
911
]
],
[
[
530,
63,
217
],
[
217,
1,
911
]
],
[
[
530,
24,
240
],
[
240,
1,
911
]
],
[
[
530,
21,
29093
],
[
29093,
6... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
]... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Azilsartan medox... |
DB04946 | DB11986 | 924 | 484 | [
"DDInter907",
"DDInter648"
] | Iloperidone | Entrectinib | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
924,
25,
484
]
],
[
[
924,
62,
112
],
[
112,
23,
484
]
],
[
[
924,
63,
222
],
[
222,
23,
484
]
],
[
[
924,
25,
774
],
[
774,
24,... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Iloperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Iloperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and ... |
DB01138 | DB12364 | 804 | 1,421 | [
"DDInter1726",
"DDInter200"
] | Sulfinpyrazone | Betrixaban | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
804,
25,
1421
]
],
[
[
804,
24,
1513
],
[
1513,
24,
1421
]
],
[
[
804,
63,
1595
],
[
1595,
24,
1421
]
],
[
[
804,
63,
714
],
[
714,
... | [
[
[
"Sulfinpyrazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apremilast"
],
[
"Ap... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Apremilast and Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Collagenase c... |
DB01176 | DB08815 | 537 | 154 | [
"DDInter453",
"DDInter1104"
] | Cyclizine | Lurasidone | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
537,
24,
154
]
],
[
[
537,
21,
29402
],
[
29402,
60,
154
]
],
[
[
537,
24,
1532
],
[
1532,
24,
154
]
],
[
[
537,
63,
1242
],
[
1242,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Cyclizine",
"{u} (Compound) causes {v} (Side Effect)",
"Hepatobiliary disease"
],
[
"Hepatobiliary disease",
"{u}... | Cyclizine (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Lurasidone (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases w... |
DB00414 | DB09046 | 590 | 1,094 | [
"DDInter16",
"DDInter1201"
] | Acetohexamide | Metreleptin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
590,
24,
1094
]
],
[
[
590,
63,
168
],
[
168,
23,
1094
]
],
[
[
590,
24,
1254
],
[
1254,
24,
1094
]
],
[
[
590,
63,
176
],
[
176,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Metreleptin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisin... |
DB06290 | DB12364 | 1,449 | 1,421 | [
"DDInter1673",
"DDInter200"
] | Simeprevir | Betrixaban | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1449,
24,
1421
]
],
[
[
1449,
25,
760
],
[
760,
24,
1421
]
],
[
[
1449,
24,
971
],
[
971,
24,
1421
]
],
[
[
1449,
25,
498
],
[
498,
... | [
[
[
"Simeprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
],
[
"Cobicistat... | Simeprevir may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may ca... |
DB00108 | DB06810 | 1,066 | 397 | [
"DDInter1268",
"DDInter1484"
] | Natalizumab | Plicamycin | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Major | 2 | [
[
[
1066,
25,
397
]
],
[
[
1066,
24,
151
],
[
151,
63,
397
]
],
[
[
1066,
64,
1184
],
[
1184,
24,
397
]
],
[
[
1066,
25,
384
],
[
384,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plicamycin"
]
],
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H... | Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) and Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) may cause a moderate interaction that could exacerba... |
DB01142 | DB01364 | 1,264 | 22 | [
"DDInter593",
"DDInter650"
] | Doxepin | Ephedrine | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Major | 2 | [
[
[
1264,
25,
22
]
],
[
[
1264,
63,
80
],
[
80,
24,
22
]
],
[
[
1264,
24,
93
],
[
93,
63,
22
]
],
[
[
1264,
6,
5214
],
[
5214,
45,
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ephedrine"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
[
"Amphetamine",
... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Dextroamphetamine and Dext... |
DB00445 | DB00519 | 322 | 1,638 | [
"DDInter655",
"DDInter1843"
] | Epirubicin | Trandolapril | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
322,
24,
1638
]
],
[
[
322,
24,
954
],
[
954,
40,
1638
]
],
[
[
322,
7,
5182
],
[
5182,
45,
1638
]
],
[
[
322,
21,
29305
],
[
29305,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Epirubicin (Compound) upregulates CES1 (Gene) and CES1 (Gene) is bound by Trandolapril (Compound)
Epirubicin (Compound) causes Dysgeusia (Side Effect) and Dysge... |
DB00619 | DB08881 | 1,419 | 868 | [
"DDInter909",
"DDInter1925"
] | Imatinib | Vemurafenib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
1419,
24,
868
]
],
[
[
1419,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1419,
7,
3422
],
[
3422,
46,
868
]
],
[
[
1419,
18,
2947
],
[
2947,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Imatinib (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Vemurafenib (Compound)
Imatinib (Compound) downregulates DECR1 (Gene) and DECR1 (Gene) is upregulated by Vemurafenib (Compound)
Imatinib (Compound)... |
DB00366 | DB00708 | 1,594 | 1,454 | [
"DDInter600",
"DDInter1718"
] | Doxylamine | Sufentanil | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
1594,
24,
1454
]
],
[
[
1594,
24,
704
],
[
704,
40,
1454
]
],
[
[
1594,
21,
28658
],
[
28658,
60,
1454
]
],
[
[
1594,
24,
537
],
[
537... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Doxylamine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Sufentanil (Compound)
Doxylamine may cause a moderate interaction that c... |
DB01176 | DB04948 | 537 | 1,084 | [
"DDInter453",
"DDInter1083"
] | Cyclizine | Lofexidine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
537,
24,
1084
]
],
[
[
537,
63,
1617
],
[
1617,
1,
1084
]
],
[
[
537,
24,
1311
],
[
1311,
24,
1084
]
],
[
[
537,
63,
701
],
[
701,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interactio... |
DB01165 | DB11093 | 1,539 | 636 | [
"DDInter1325",
"DDInter273"
] | Ofloxacin | Calcium citrate | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1539,
24,
636
]
],
[
[
1539,
40,
739
],
[
739,
24,
636
]
],
[
[
1539,
1,
956
],
[
956,
24,
636
]
],
[
[
1539,
24,
115
],
[
115,
... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Ofloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u} may cause a ... | Ofloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Ofloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ca... |
DB11988 | DB14962 | 270 | 1,363 | [
"DDInter1321",
"DDInter1847"
] | Ocrelizumab | Trastuzumab deruxtecan | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes i... | Moderate | 1 | [
[
[
270,
24,
1363
]
],
[
[
270,
63,
1430
],
[
1430,
24,
1363
]
],
[
[
270,
63,
507
],
[
507,
25,
1363
]
],
[
[
270,
64,
1259
],
[
1259,
... | [
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab deruxtecan"
]
],
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"... | Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab deruxtecan
Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sam... |
DB00307 | DB08868 | 1,101 | 1,011 | [
"DDInter202",
"DDInter737"
] | Bexarotene | Fingolimod | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1101,
25,
1011
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
1101,
21,
29097
],
[
29097,
60,
1011
]
],
[
[
1101,
24,
578
],
[
57... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Bexarotene (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Fingolimod (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagr... |
DB08881 | DB12267 | 868 | 1,476 | [
"DDInter1925",
"DDInter233"
] | Vemurafenib | Brigatinib | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
868,
24,
1476
]
],
[
[
868,
25,
1612
],
[
1612,
23,
1476
]
],
[
[
868,
23,
1135
],
[
1135,
23,
1476
]
],
[
[
868,
62,
168
],
[
168,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostems... | Vemurafenib may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a ... |
DB08879 | DB15091 | 632 | 676 | [
"DDInter173",
"DDInter1901"
] | Belimumab | Upadacitinib | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
632,
25,
676
]
],
[
[
632,
23,
1193
],
[
1193,
23,
676
]
],
[
[
632,
62,
1461
],
[
1461,
23,
676
]
],
[
[
632,
63,
1430
],
[
1430,
... | [
[
[
"Belimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Belimumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc glu... | Belimumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Belimumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitam... |
DB00970 | DB01033 | 0 | 328 | [
"DDInter466",
"DDInter1156"
] | Dactinomycin | Mercaptopurine | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
0,
24,
328
]
],
[
[
0,
7,
11104
],
[
11104,
45,
328
]
],
[
[
0,
21,
28681
],
[
28681,
60,
328
]
],
[
[
0,
62,
1299
],
[
1299,
23... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Dactinomycin",
"{u} (Compound) upregulates {v} (Gene)",
"TPMT"
],
[
"TPMT",
"{u} (Gene) is bound by {v} (C... | Dactinomycin (Compound) upregulates TPMT (Gene) and TPMT (Gene) is bound by Mercaptopurine (Compound)
Dactinomycin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mercaptopurine (Compound)
Dactinomycin may cause a minor interaction that can limit clinical effects when ta... |
DB00802 | DB12500 | 1,322 | 283 | [
"DDInter43",
"DDInter714"
] | Alfentanil | Fedratinib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1322,
25,
283
]
],
[
[
1322,
24,
351
],
[
351,
23,
283
]
],
[
[
1322,
25,
1593
],
[
1593,
23,
283
]
],
[
[
1322,
64,
1419
],
[
1419,
... | [
[
[
"Alfentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
"Ribociclib... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Alfentanil may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a ... |
DB00108 | DB00970 | 1,066 | 0 | [
"DDInter1268",
"DDInter466"
] | Natalizumab | Dactinomycin | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Major | 2 | [
[
[
1066,
25,
0
]
],
[
[
1066,
25,
259
],
[
259,
63,
0
]
],
[
[
1066,
24,
496
],
[
496,
63,
0
]
],
[
[
1066,
64,
1184
],
[
1184,
24,... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dactinomycin"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacept",
"{... | Natalizumab may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatiti... |
DB00295 | DB01069 | 475 | 401 | [
"DDInter1244",
"DDInter1533"
] | Morphine | Promethazine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
475,
24,
401
]
],
[
[
475,
25,
146
],
[
146,
24,
401
]
],
[
[
475,
24,
1264
],
[
1264,
63,
401
]
],
[
[
475,
24,
1236
],
[
1236,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Propiomazine"
],
[
"Propiomazi... | Morphine may lead to a major life threatening interaction when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a mo... |
DB00834 | DB08881 | 932 | 868 | [
"DDInter1215",
"DDInter1925"
] | Mifepristone | Vemurafenib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
932,
25,
868
]
],
[
[
932,
6,
8374
],
[
8374,
45,
868
]
],
[
[
932,
7,
2884
],
[
2884,
46,
868
]
],
[
[
932,
18,
2852
],
[
2852,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ve... | Mifepristone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Mifepristone (Compound) upregulates ECH1 (Gene) and ECH1 (Gene) is upregulated by Vemurafenib (Compound)
Mifepristone (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Vemurafenib (Compound)
Mifepri... |
DB00748 | DB00909 | 662 | 306 | [
"DDInter297",
"DDInter1971"
] | Carbinoxamine | Zonisamide | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Major | 2 | [
[
[
662,
25,
306
]
],
[
[
662,
6,
8374
],
[
8374,
45,
306
]
],
[
[
662,
21,
28691
],
[
28691,
60,
306
]
],
[
[
662,
24,
1609
],
[
1609,
... | [
[
[
"Carbinoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zonisamide"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Z... | Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Carbinoxamine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Zonisamide (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyv... |
DB00252 | DB00372 | 362 | 999 | [
"DDInter1460",
"DDInter1793"
] | Phenytoin | Thiethylperazine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
362,
24,
999
]
],
[
[
362,
24,
460
],
[
460,
62,
999
]
],
[
[
362,
24,
417
],
[
417,
23,
999
]
],
[
[
362,
24,
1614
],
[
1614,
6... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonate and Magnesium carbonate may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB00860 | DB01155 | 891 | 872 | [
"DDInter1513",
"DDInter813"
] | Prednisolone | Gemifloxacin | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Major | 2 | [
[
[
891,
25,
872
]
],
[
[
891,
25,
739
],
[
739,
1,
872
]
],
[
[
891,
64,
1299
],
[
1299,
1,
872
]
],
[
[
891,
25,
945
],
[
945,
40,... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Prednisolone may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Prednisolone may lead to a major life threatening interaction when taken with Trovafloxacin and Trovafloxacin (Compound) resembles Gemifloxacin (Compound)
Prednisolone... |
DB00563 | DB13179 | 663 | 68 | [
"DDInter1174",
"DDInter1882"
] | Methotrexate | Troleandomycin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
663,
24,
68
]
],
[
[
663,
25,
319
],
[
319,
23,
68
]
],
[
[
663,
63,
1101
],
[
1101,
23,
68
]
],
[
[
663,
24,
1374
],
[
1374,
23... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amoxicillin"
],
[
"A... | Methotrexate may lead to a major life threatening interaction when taken with Amoxicillin and Amoxicillin may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene ma... |
DB09122 | DB15822 | 1,613 | 69 | [
"DDInter1409",
"DDInter1504"
] | Peginterferon beta-1a | Pralsetinib | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1613,
24,
69
]
],
[
[
1613,
24,
283
],
[
283,
24,
69
]
],
[
[
1613,
63,
1648
],
[
1648,
24,
69
]
],
[
[
1613,
63,
609
],
[
609,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedr... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00444 | DB10315 | 63 | 1,137 | [
"DDInter1765",
"DDInter1127"
] | Teniposide | Measles virus vaccine live attenuated | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
63,
25,
1137
]
],
[
[
63,
64,
581
],
[
581,
25,
1137
]
],
[
[
63,
24,
384
],
[
384,
25,
1137
]
],
[
[
63,
63,
1184
],
[
1184,
25... | [
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Teniposide may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB00254 | DB13749 | 964 | 1,473 | [
"DDInter598",
"DDInter1116"
] | Doxycycline | Magnesium gluconate | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
964,
24,
1473
]
],
[
[
964,
24,
544
],
[
544,
24,
1473
]
],
[
[
964,
1,
1572
],
[
1572,
24,
1473
]
],
[
[
964,
40,
1620
],
[
1620,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfat... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Doxycycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause ... |
DB00424 | DB04908 | 19 | 1,671 | [
"DDInter896",
"DDInter741"
] | Hyoscyamine | Flibanserin | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
19,
24,
1671
]
],
[
[
19,
24,
830
],
[
830,
24,
1671
]
],
[
[
19,
63,
1594
],
[
1594,
24,
1671
]
],
[
[
19,
24,
407
],
[
407,
63... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
],
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and... |
DB10583 | DB11988 | 949 | 270 | [
"DDInter415",
"DDInter1321"
] | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Ocrelizumab | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
949,
24,
270
]
],
[
[
949,
63,
134
],
[
134,
24,
270
]
],
[
[
949,
24,
1019
],
[
1019,
24,
270
]
],
[
[
949,
24,
398
],
[
398,
6... | [
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderat... | Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Clostridium tetani toxoid antigen (formaldehyde inactivated... |
DB01035 | DB09268 | 1,401 | 1,662 | [
"DDInter1524",
"DDInter1464"
] | Procainamide | Picosulfuric acid | A derivative of procaine with less CNS action. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
1401,
25,
1662
]
],
[
[
1401,
25,
484
],
[
484,
63,
1662
]
],
[
[
1401,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1401,
64,
1555
],
[
1555... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"Entrectinib",... | Procainamide may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Procainamide may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may caus... |
DB00026 | DB14811 | 1,184 | 385 | [
"DDInter94",
"DDInter979"
] | Anakinra | Isatuximab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
1184,
24,
385
]
],
[
[
1184,
24,
1362
],
[
1362,
24,
385
]
],
[
[
1184,
25,
908
],
[
908,
25,
385
]
],
[
[
1184,
25,
676
],
[
676,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
"O... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Anakinra may lead to a major life threatening interaction when taken with Golimumab and Golimumab may lead to a major ... |
DB01118 | DB06674 | 33 | 908 | [
"DDInter76",
"DDInter837"
] | Amiodarone | Golimumab | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
33,
24,
908
]
],
[
[
33,
63,
268
],
[
268,
24,
908
]
],
[
[
33,
25,
1487
],
[
1487,
24,
908
]
],
[
[
33,
64,
467
],
[
467,
24,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
]... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Amiodarone may lead to a major life threatening interaction when taken with Hydroxychloroqu... |
DB00690 | DB06723 | 1,216 | 115 | [
"DDInter762",
"DDInter58"
] | Flurazepam | Aluminum hydroxide | A benzodiazepine derivative used mainly as a hypnotic. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
1216,
23,
115
]
],
[
[
1216,
40,
1565
],
[
1565,
23,
115
]
],
[
[
1216,
24,
401
],
[
401,
23,
115
]
],
[
[
1216,
1,
481
],
[
481,
... | [
[
[
"Flurazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Flurazepam",
"{u} (Compound) resembles {v} (Compound)",
"Clonazepam"
],
[
"Clonazepam",
"{u} may cause a m... | Flurazepam (Compound) resembles Clonazepam (Compound) and Clonazepam may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction tha... |
DB00041 | DB00231 | 1,648 | 1,174 | [
"DDInter38",
"DDInter1761"
] | Aldesleukin | Temazepam | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Moderate | 1 | [
[
[
1648,
24,
1174
]
],
[
[
1648,
24,
902
],
[
902,
40,
1174
]
],
[
[
1648,
24,
1382
],
[
1382,
1,
1174
]
],
[
[
1648,
25,
695
],
[
695,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temazepam"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clobazam"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Temazepam (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Temazepam (Compound)
Aldesl... |
DB00762 | DB12825 | 613 | 1,375 | [
"DDInter973",
"DDInter1032"
] | Irinotecan | Lefamulin | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
613,
24,
1375
]
],
[
[
613,
24,
159
],
[
159,
63,
1375
]
],
[
[
613,
25,
976
],
[
976,
24,
1375
]
],
[
[
613,
63,
1101
],
[
1101,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Irinotecan may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may... |
DB06603 | DB10315 | 39 | 1,137 | [
"DDInter1387",
"DDInter1127"
] | Panobinostat | Measles virus vaccine live attenuated | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
39,
25,
1137
]
],
[
[
39,
64,
581
],
[
581,
25,
1137
]
],
[
[
39,
24,
384
],
[
384,
25,
1137
]
],
[
[
39,
63,
1101
],
[
1101,
25... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Panobinostat may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idela... |
DB00827 | DB09038 | 646 | 1,450 | [
"DDInter383",
"DDInter636"
] | Cinoxacin | Empagliflozin | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
646,
24,
1450
]
],
[
[
646,
25,
1486
],
[
1486,
24,
1450
]
],
[
[
646,
64,
1179
],
[
1179,
24,
1450
]
],
[
[
646,
63,
417
],
[
417,
... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Cinoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
],
[
"M... | Cinoxacin may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Cinoxacin may lead to a major life threatening interaction when taken with Insulin lispro and Insulin lispro ... |
DB00539 | DB14881 | 11 | 180 | [
"DDInter1837",
"DDInter1329"
] | Toremifene | Oliceridine | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
11,
25,
180
]
],
[
[
11,
23,
112
],
[
112,
23,
180
]
],
[
[
11,
25,
401
],
[
401,
24,
180
]
],
[
[
11,
24,
1094
],
[
1094,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Toremifene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Toremifene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Toremifene may lead to a major life threatening interaction when taken with Promethazine and Promethazine may... |
DB00022 | DB04865 | 268 | 4 | [
"DDInter1408",
"DDInter1335"
] | Peginterferon alfa-2b | Omacetaxine mepesuccinate | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
268,
24,
4
]
],
[
[
268,
24,
770
],
[
770,
24,
4
]
],
[
[
268,
24,
713
],
[
713,
63,
4
]
],
[
[
268,
25,
1101
],
[
1101,
24,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate disease... |
DB00444 | DB10316 | 63 | 334 | [
"DDInter1765",
"DDInter1248"
] | Teniposide | Mumps virus strain B level jeryl lynn live antigen | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
63,
25,
334
]
],
[
[
63,
64,
1057
],
[
1057,
25,
334
]
],
[
[
63,
25,
908
],
[
908,
25,
334
]
],
[
[
63,
24,
310
],
[
310,
25,
... | [
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Teniposide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Teniposide may lead to a major life threatening interaction when taken with Golimumab and Golimumab ma... |
DB00372 | DB01261 | 999 | 170 | [
"DDInter1793",
"DDInter1679"
] | Thiethylperazine | Sitagliptin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
999,
24,
170
]
],
[
[
999,
24,
52
],
[
52,
62,
170
]
],
[
[
999,
24,
623
],
[
623,
24,
170
]
],
[
[
999,
24,
924
],
[
924,
63,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Quetiapi... |
DB00242 | DB01004 | 1,064 | 563 | [
"DDInter392",
"DDInter806"
] | Cladribine | Ganciclovir | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Major | 2 | [
[
[
1064,
25,
563
]
],
[
[
1064,
24,
1295
],
[
1295,
1,
563
]
],
[
[
1064,
25,
248
],
[
248,
40,
563
]
],
[
[
1064,
6,
10715
],
[
10715,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ganciclovir"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valaciclovir"
],
[
"Valacic... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Valaciclovir and Valaciclovir (Compound) resembles Ganciclovir (Compound)
Cladribine may lead to a major life threatening interaction when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
C... |
DB01244 | DB09104 | 762 | 286 | [
"DDInter192",
"DDInter1118"
] | Bepridil | Magnesium hydroxide | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
762,
24,
286
]
],
[
[
762,
64,
401
],
[
401,
23,
286
]
],
[
[
762,
63,
1559
],
[
1559,
23,
286
]
],
[
[
762,
63,
688
],
[
688,
2... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
"Pro... | Bepridil may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may... |
DB00377 | DB00694 | 1,494 | 51 | [
"DDInter1382",
"DDInter485"
] | Palonosetron | Daunorubicin | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
1494,
24,
51
]
],
[
[
1494,
6,
7950
],
[
7950,
45,
51
]
],
[
[
1494,
21,
29473
],
[
29473,
60,
51
]
],
[
[
1494,
23,
112
],
[
112,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compo... | Palonosetron (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Daunorubicin (Compound)
Palonosetron (Compound) causes Induration (Side Effect) and Induration (Side Effect) is caused by Daunorubicin (Compound)
Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronida... |
DB09034 | DB09046 | 1,313 | 1,094 | [
"DDInter1733",
"DDInter1201"
] | Suvorexant | Metreleptin | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
1313,
24,
1094
]
],
[
[
1313,
23,
1135
],
[
1135,
63,
1094
]
],
[
[
1313,
63,
866
],
[
866,
24,
1094
]
],
[
[
1313,
24,
927
],
[
927,
... | [
[
[
"Suvorexant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Suvorexant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Suvorexant may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Suvorexant may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib and Cobimeti... |
DB00564 | DB08816 | 1,236 | 578 | [
"DDInter293",
"DDInter1802"
] | Carbamazepine | Ticagrelor | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
1236,
25,
578
]
],
[
[
1236,
6,
4973
],
[
4973,
45,
578
]
],
[
[
1236,
21,
28646
],
[
28646,
60,
578
]
],
[
[
1236,
25,
1135
],
[
1135... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Tic... | Carbamazepine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Carbamazepine (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Carbamazepine may le... |
DB01124 | DB04946 | 1,411 | 924 | [
"DDInter1828",
"DDInter907"
] | Tolbutamide | Iloperidone | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
1411,
24,
924
]
],
[
[
1411,
63,
1664
],
[
1664,
1,
924
]
],
[
[
1411,
24,
519
],
[
519,
40,
924
]
],
[
[
1411,
21,
28680
],
[
28680,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone (... |
DB00361 | DB00365 | 134 | 839 | [
"DDInter1939",
"DDInter842"
] | Vinorelbine | Grepafloxacin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Minor | 0 | [
[
[
134,
23,
839
]
],
[
[
134,
24,
1488
],
[
1488,
62,
839
]
],
[
[
134,
63,
329
],
[
329,
23,
839
]
],
[
[
134,
24,
1670
],
[
1670,
... | [
[
[
"Vinorelbine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Grepafloxacin"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Bleomycin and Bl... |
DB01501 | DB05541 | 1,118 | 801 | [
"DDInter549",
"DDInter239"
] | Difenoxin | Brivaracetam | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
1118,
24,
801
]
],
[
[
1118,
24,
649
],
[
649,
24,
801
]
],
[
[
1118,
1,
1688
],
[
1688,
24,
801
]
],
[
[
1118,
24,
516
],
[
516,
... | [
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Brivaracetam
Difenoxin (Compound) resembles Diphenoxylate (Compound) and Diphenoxylate may cause a moderate interaction that... |
DB00075 | DB09322 | 541 | 1,114 | [
"DDInter1250",
"DDInter1966"
] | Muromonab | Zinc sulfate | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Minor | 0 | [
[
[
541,
23,
1114
]
],
[
[
541,
64,
1057
],
[
1057,
23,
1114
]
],
[
[
541,
24,
259
],
[
259,
23,
1114
]
],
[
[
541,
63,
1184
],
[
1184,
... | [
[
[
"Muromonab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Muromonab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
],
[
"Etanercept",... | Muromonab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a ... |
DB01394 | DB06317 | 1,554 | 1,626 | [
"DDInter431",
"DDInter630"
] | Colchicine | Elotuzumab | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
1554,
24,
1626
]
],
[
[
1554,
63,
973
],
[
973,
24,
1626
]
],
[
[
1554,
24,
310
],
[
310,
63,
1626
]
],
[
[
1554,
24,
1487
],
[
1487,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabaz... |
DB00524 | DB00563 | 811 | 663 | [
"DDInter1199",
"DDInter1174"
] | Metolazone | Methotrexate | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
811,
24,
663
]
],
[
[
811,
21,
28681
],
[
28681,
60,
663
]
],
[
[
811,
23,
126
],
[
126,
62,
663
]
],
[
[
811,
24,
1287
],
[
1287,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Metolazone",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side... | Metolazone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Metolazone may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with... |
DB00754 | DB00792 | 157 | 832 | [
"DDInter696",
"DDInter1878"
] | Ethotoin | Tripelennamine | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
157,
24,
832
]
],
[
[
157,
24,
100
],
[
100,
63,
832
]
],
[
[
157,
24,
649
],
[
649,
1,
832
]
],
[
[
157,
63,
1594
],
[
1594,
24... | [
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
... | Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol ... |
DB00455 | DB12825 | 1,601 | 1,375 | [
"DDInter1091",
"DDInter1032"
] | Loratadine | Lefamulin | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1601,
24,
1375
]
],
[
[
1601,
24,
159
],
[
159,
63,
1375
]
],
[
[
1601,
24,
98
],
[
98,
24,
1375
]
],
[
[
1601,
63,
1324
],
[
1324,
... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Som... |
DB01064 | DB09078 | 1,148 | 1,228 | [
"DDInter987",
"DDInter1036"
] | Isoprenaline | Lenvatinib | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
1148,
24,
1228
]
],
[
[
1148,
63,
1100
],
[
1100,
24,
1228
]
],
[
[
1148,
24,
938
],
[
938,
63,
1228
]
],
[
[
1148,
24,
609
],
[
609,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant and ... |
DB00704 | DB01132 | 267 | 1,130 | [
"DDInter1263",
"DDInter1472"
] | Naltrexone | Pioglitazone | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
267,
24,
1130
]
],
[
[
267,
21,
28661
],
[
28661,
60,
1130
]
],
[
[
267,
24,
242
],
[
242,
63,
1130
]
],
[
[
267,
24,
1072
],
[
1072,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Naltrexone",
"{u} (Compound) causes {v} (Side Effect)",
"Acute coronary syndrome"
],
[
"Acute coronary syndrome",
... | Naltrexone (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Pioglitazone (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate di... |
DB00153 | DB11057 | 1,331 | 720 | [
"DDInter662",
"DDInter1223"
] | Ergocalciferol | Mineral oil | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1331,
24,
720
]
],
[
[
1331,
24,
323
],
[
323,
24,
720
]
],
[
[
1331,
64,
160
],
[
160,
24,
720
]
],
[
[
1331,
36,
386
],
[
386,
... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bendroflumethiazid... | Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Ergocalciferol may lead to a major life threatening interaction when taken with Calcifedi... |
DB00792 | DB04844 | 832 | 843 | [
"DDInter1878",
"DDInter1778"
] | Tripelennamine | Tetrabenazine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
832,
24,
843
]
],
[
[
832,
24,
479
],
[
479,
40,
843
]
],
[
[
832,
6,
12523
],
[
12523,
45,
843
]
],
[
[
832,
40,
649
],
[
649,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Tripelennamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Tripelennamine (Compound) resembles Clofedanol (Compou... |
DB00594 | DB09156 | 863 | 777 | [
"DDInter68",
"DDInter964"
] | Amiloride | Iopromide | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
863,
24,
777
]
],
[
[
863,
63,
1648
],
[
1648,
24,
777
]
],
[
[
863,
63,
1512
],
[
1512,
25,
777
]
],
[
[
863,
24,
848
],
[
848,
... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofe... |
DB00549 | DB00580 | 522 | 311 | [
"DDInter1955",
"DDInter1910"
] | Zafirlukast | Valdecoxib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
522,
24,
311
]
],
[
[
522,
24,
473
],
[
473,
63,
311
]
],
[
[
522,
24,
663
],
[
663,
24,
311
]
],
[
[
522,
63,
1560
],
[
1560,
2... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and ... |
DB06176 | DB11003 | 1,342 | 748 | [
"DDInter1616",
"DDInter100"
] | Romidepsin | Anthrax vaccine | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1342,
24,
748
]
],
[
[
1342,
63,
322
],
[
322,
24,
748
]
],
[
[
1342,
25,
676
],
[
676,
63,
748
]
],
[
[
1342,
24,
1619
],
[
1619,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Romidepsin may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib m... |
DB00417 | DB00759 | 1,667 | 1,620 | [
"DDInter1445",
"DDInter1783"
] | Phenoxymethylpenicillin | Tetracycline | Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK. It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, s... | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
1667,
24,
1620
]
],
[
[
1667,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
1667,
63,
964
],
[
964,
40,
1620
]
],
[
[
1667,
24,
126
],
[
126,
... | [
[
[
"Phenoxymethylpenicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Phenoxymethylpenicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Phenoxymethylpenicillin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Phenoxymethylpenicillin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Comp... |
DB00496 | DB12130 | 194 | 1,017 | [
"DDInter480",
"DDInter1094"
] | Darifenacin | Lorlatinib | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
194,
24,
1017
]
],
[
[
194,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
194,
25,
888
],
[
888,
24,
1017
]
],
[
[
194,
24,
1493
],
[
1493,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Darifenacin may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a ... |
DB00218 | DB00563 | 1,176 | 663 | [
"DDInter1247",
"DDInter1174"
] | Moxifloxacin | Methotrexate | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1176,
24,
663
]
],
[
[
1176,
6,
3199
],
[
3199,
57,
663
]
],
[
[
1176,
21,
28681
],
[
28681,
60,
663
]
],
[
[
1176,
23,
328
],
[
328,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) binds {v} (Gene)",
"TOP2A"
],
[
"TOP2A",
"{u} (Gene) is downregulated by {v} ... | Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Methotrexate (Compound)
Moxifloxacin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when ta... |
DB00399 | DB12015 | 963 | 1,033 | [
"DDInter1968",
"DDInter53"
] | Zoledronic acid | Alpelisib | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
963,
24,
1033
]
],
[
[
963,
25,
629
],
[
629,
24,
1033
]
],
[
[
963,
40,
1485
],
[
1485,
24,
1033
]
],
[
[
963,
1,
1199
],
[
1199,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Zoledronic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
],
[
"Si... | Zoledronic acid may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Zoledronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid may cause a moderate interaction that cou... |
DB01263 | DB08865 | 859 | 1,593 | [
"DDInter1494",
"DDInter448"
] | Posaconazole | Crizotinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
859,
25,
1593
]
],
[
[
859,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
859,
21,
29093
],
[
29093,
60,
1593
]
],
[
[
859,
25,
283
],
[
283,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Posaconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cri... | Posaconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Posaconazole (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Posaconazole may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may ca... |
DB00652 | DB01105 | 234 | 222 | [
"DDInter1421",
"DDInter1665"
] | Pentazocine | Sibutramine | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
234,
25,
222
]
],
[
[
234,
21,
28698
],
[
28698,
60,
222
]
],
[
[
234,
63,
752
],
[
752,
23,
222
]
],
[
[
234,
63,
128
],
[
128,
... | [
[
[
"Pentazocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Pentazocine",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused by {v} (Com... | Pentazocine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Sibutram... |
DB00491 | DB01165 | 127 | 1,539 | [
"DDInter1217",
"DDInter1325"
] | Miglitol | Ofloxacin | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
127,
24,
1539
]
],
[
[
127,
63,
1467
],
[
1467,
1,
1539
]
],
[
[
127,
24,
945
],
[
945,
40,
1539
]
],
[
[
127,
24,
739
],
[
739,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
],
[
"En... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Miglit... |
DB00765 | DB00835 | 1,266 | 100 | [
"DDInter1205",
"DDInter245"
] | Metyrosine | Brompheniramine | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1266,
24,
100
]
],
[
[
1266,
24,
832
],
[
832,
24,
100
]
],
[
[
1266,
63,
128
],
[
128,
24,
100
]
],
[
[
1266,
24,
649
],
[
649,
... | [
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],... | Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Dexbromp... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.