drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00193 | DB01168 | 534 | 1,053 | [
"DDInter1841",
"DDInter1526"
] | Tramadol | Procarbazine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
534,
25,
1053
]
],
[
[
534,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
534,
24,
126
],
[
126,
23,
1053
]
],
[
[
534,
24,
480
],
[
480,
... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Tramadol",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compound... | Tramadol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Tram... |
DB00290 | DB05273 | 329 | 507 | [
"DDInter219",
"DDInter1638"
] | Bleomycin | Samarium (153Sm) lexidronam | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
329,
25,
507
]
],
[
[
329,
24,
248
],
[
248,
24,
507
]
],
[
[
329,
24,
270
],
[
270,
63,
507
]
],
[
[
329,
24,
970
],
[
970,
25,... | [
[
[
"Bleomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00254 | DB01337 | 964 | 1,579 | [
"DDInter598",
"DDInter1385"
] | Doxycycline | Pancuronium | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release. | Moderate | 1 | [
[
[
964,
24,
1579
]
],
[
[
964,
24,
1610
],
[
1610,
1,
1579
]
],
[
[
964,
24,
544
],
[
544,
24,
1579
]
],
[
[
964,
23,
1424
],
[
1424,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pancuronium"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
],
[... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate inter... |
DB00486 | DB00697 | 1,614 | 876 | [
"DDInter1253",
"DDInter1821"
] | Nabilone | Tizanidine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
1614,
24,
876
]
],
[
[
1614,
24,
1617
],
[
1617,
1,
876
]
],
[
[
1614,
21,
29054
],
[
29054,
60,
876
]
],
[
[
1614,
24,
401
],
[
401,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Tizanidine (Compound)
Nabilone (Compound) causes Speech disorder (Side Effect) and Speech disorder (Side Effect) is caused by Tizanidine (Compound)
Nabilone may cause a moderate ... |
DB00408 | DB00692 | 1,408 | 274 | [
"DDInter1099",
"DDInter1448"
] | Loxapine | Phentolamine | An antipsychotic agent used in schizophrenia. [PubChem] | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
1408,
24,
274
]
],
[
[
1408,
6,
5372
],
[
5372,
45,
274
]
],
[
[
1408,
21,
29118
],
[
29118,
60,
274
]
],
[
[
1408,
1,
695
],
[
695,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Loxapine",
"{u} (Compound) binds {v} (Gene)",
"ADRA2A"
],
[
"ADRA2A",
"{u} (Gene) is bound by {v} (Compound)",
... | Loxapine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Phentolamine (Compound)
Loxapine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Loxapine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that cou... |
DB00285 | DB13074 | 1,100 | 877 | [
"DDInter1927",
"DDInter1110"
] | Venlafaxine | Macimorelin | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1100,
25,
877
]
],
[
[
1100,
23,
112
],
[
112,
23,
877
]
],
[
[
1100,
24,
1479
],
[
1479,
24,
877
]
],
[
[
1100,
63,
1324
],
[
1324,
... | [
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Venlafaxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Venlafaxine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic ... |
DB00524 | DB00682 | 811 | 126 | [
"DDInter1199",
"DDInter1951"
] | Metolazone | Warfarin | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
811,
23,
126
]
],
[
[
811,
24,
135
],
[
135,
62,
126
]
],
[
[
811,
40,
1014
],
[
1014,
23,
126
]
],
[
[
811,
1,
359
],
[
359,
62... | [
[
[
"Metolazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
],
[
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide and Albiglutide may cause a minor interaction that can limit clinical effects when taken with Warfarin
Metolazone (Compound) resembles Benzthiazide (Compound) and Benzthiazide may cause a minor interaction that can li... |
DB00445 | DB00550 | 322 | 99 | [
"DDInter655",
"DDInter1541"
] | Epirubicin | Propylthiouracil | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Moderate | 1 | [
[
[
322,
24,
99
]
],
[
[
322,
7,
2178
],
[
2178,
46,
99
]
],
[
[
322,
18,
6056
],
[
6056,
57,
99
]
],
[
[
322,
21,
28957
],
[
28957,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propylthiouracil"
]
],
[
[
"Epirubicin",
"{u} (Compound) upregulates {v} (Gene)",
"NFKB2"
],
[
"NFKB2",
"{u} (Gene) is upregulated by ... | Epirubicin (Compound) upregulates NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Propylthiouracil (Compound)
Epirubicin (Compound) downregulates EXOSC4 (Gene) and EXOSC4 (Gene) is downregulated by Propylthiouracil (Compound)
Epirubicin (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused b... |
DB00570 | DB08904 | 147 | 375 | [
"DDInter1936",
"DDInter342"
] | Vinblastine | Certolizumab pegol | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
147,
25,
375
]
],
[
[
147,
63,
1461
],
[
1461,
23,
375
]
],
[
[
147,
24,
231
],
[
231,
24,
375
]
],
[
[
147,
24,
200
],
[
200,
6... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"V... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and S... |
DB00748 | DB11160 | 662 | 337 | [
"DDInter297",
"DDInter1459"
] | Carbinoxamine | Phenyltoloxamine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
662,
24,
337
]
],
[
[
662,
23,
771
],
[
771,
62,
337
]
],
[
[
662,
24,
820
],
[
820,
24,
337
]
],
[
[
662,
63,
999
],
[
999,
24,... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Carbinoxamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Carbinoxamine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyltoloxamine
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Alimema... |
DB00361 | DB04908 | 134 | 1,671 | [
"DDInter1939",
"DDInter741"
] | Vinorelbine | Flibanserin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
134,
24,
1671
]
],
[
[
134,
63,
168
],
[
168,
23,
1671
]
],
[
[
134,
24,
741
],
[
741,
63,
1671
]
],
[
[
134,
24,
51
],
[
51,
24... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Flibanserin
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolap... |
DB00448 | DB09143 | 1,215 | 313 | [
"DDInter1022",
"DDInter1701"
] | Lansoprazole | Sonidegib | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Minor | 0 | [
[
[
1215,
23,
313
]
],
[
[
1215,
40,
837
],
[
837,
23,
313
]
],
[
[
1215,
24,
478
],
[
478,
24,
313
]
],
[
[
1215,
24,
1375
],
[
1375,
... | [
[
[
"Lansoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sonidegib"
]
],
[
[
"Lansoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Pantoprazole"
],
[
"Pantoprazole",
"{u} may cause a mi... | Lansoprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that co... |
DB08880 | DB15066 | 1,510 | 445 | [
"DDInter1771",
"DDInter821"
] | Teriflunomide | Givosiran | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Major | 2 | [
[
[
1510,
25,
445
]
],
[
[
1510,
64,
1555
],
[
1555,
24,
445
]
],
[
[
1510,
63,
1684
],
[
1684,
24,
445
]
],
[
[
1510,
25,
1613
],
[
1613,... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Givosiran"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxaliplatin"
],
[
"Oxaliplatin",
... | Teriflunomide may lead to a major life threatening interaction when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine may cau... |
DB00342 | DB01165 | 1,181 | 1,539 | [
"DDInter1770",
"DDInter1325"
] | Terfenadine | Ofloxacin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
1181,
24,
1539
]
],
[
[
1181,
64,
1176
],
[
1176,
1,
1539
]
],
[
[
1181,
24,
956
],
[
956,
40,
1539
]
],
[
[
1181,
25,
246
],
[
246,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxiflo... | Terfenadine may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles Ofloxacin (Compound)
Terfenadi... |
DB00460 | DB00945 | 612 | 1,479 | [
"DDInter1929",
"DDInter20"
] | Verteporfin | Acetylsalicylic acid | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
612,
24,
1479
]
],
[
[
612,
21,
28931
],
[
28931,
60,
1479
]
],
[
[
612,
63,
353
],
[
353,
23,
1479
]
],
[
[
612,
24,
714
],
[
714,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Verteporfin",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side... | Verteporfin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Acetylsalicylic acid (Compound)
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when ... |
DB00701 | DB00959 | 1,091 | 1,486 | [
"DDInter90",
"DDInter1191"
] | Amprenavir | Methylprednisolone | Amprenavir is a protease inhibitor used to treat HIV infection. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
1091,
25,
1486
]
],
[
[
1091,
64,
175
],
[
175,
40,
1486
]
],
[
[
1091,
24,
167
],
[
167,
1,
1486
]
],
[
[
1091,
25,
617
],
[
617,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone"... | Amprenavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednisol... |
DB00418 | DB00673 | 536 | 723 | [
"DDInter1650",
"DDInter112"
] | Secobarbital | Aprepitant | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
536,
24,
723
]
],
[
[
536,
6,
7950
],
[
7950,
45,
723
]
],
[
[
536,
21,
28642
],
[
28642,
60,
723
]
],
[
[
536,
24,
222
],
[
222,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Secobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compoun... | Secobarbital (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Aprepitant (Compound)
Secobarbital (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Aprepitant (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibut... |
DB00254 | DB11093 | 964 | 636 | [
"DDInter598",
"DDInter273"
] | Doxycycline | Calcium citrate | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
964,
24,
636
]
],
[
[
964,
1,
1572
],
[
1572,
24,
636
]
],
[
[
964,
23,
504
],
[
504,
24,
636
]
],
[
[
964,
24,
1482
],
[
1482,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Doxycycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
"{u} may ... | Doxycycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Doxycycline may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazide may cause a ... |
DB08871 | DB11967 | 36 | 710 | [
"DDInter666",
"DDInter210"
] | Eribulin | Binimetinib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
36,
24,
710
]
],
[
[
36,
24,
1293
],
[
1293,
24,
710
]
],
[
[
36,
64,
1593
],
[
1593,
24,
710
]
],
[
[
36,
63,
1237
],
[
1237,
2... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
],
[
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine and Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Eribulin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a... |
DB00444 | DB09074 | 63 | 1,362 | [
"DDInter1765",
"DDInter1327"
] | Teniposide | Olaparib | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
63,
24,
1362
]
],
[
[
63,
35,
896
],
[
896,
24,
1362
]
],
[
[
63,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
63,
63,
491
],
[
491,
24... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Teniposide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Teniposide (Compound) resembles Etoposide (Compound) and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Teniposide may cause a moderate interaction that could exac... |
DB01148 | DB06282 | 1,128 | 516 | [
"DDInter738",
"DDInter1053"
] | Flavoxate | Levocetirizine | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1128,
24,
516
]
],
[
[
1128,
63,
701
],
[
701,
24,
516
]
],
[
[
1128,
24,
407
],
[
407,
63,
516
]
],
[
[
1128,
24,
649
],
[
649,
... | [
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may... |
DB00471 | DB08880 | 201 | 1,510 | [
"DDInter1242",
"DDInter1771"
] | Montelukast | Teriflunomide | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
201,
24,
1510
]
],
[
[
201,
24,
129
],
[
129,
63,
1510
]
],
[
[
201,
24,
1144
],
[
1144,
24,
1510
]
],
[
[
201,
24,
1622
],
[
1622,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide ... |
DB01069 | DB11853 | 401 | 230 | [
"DDInter1533",
"DDInter1577"
] | Promethazine | Relugolix | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
401,
24,
230
]
],
[
[
401,
24,
129
],
[
129,
23,
230
]
],
[
[
401,
62,
112
],
[
112,
23,
230
]
],
[
[
401,
63,
480
],
[
480,
24,... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and ... |
DB00242 | DB00853 | 1,064 | 1,686 | [
"DDInter392",
"DDInter1762"
] | Cladribine | Temozolomide | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Major | 2 | [
[
[
1064,
25,
1686
]
],
[
[
1064,
21,
28898
],
[
28898,
60,
1686
]
],
[
[
1064,
25,
970
],
[
970,
24,
1686
]
],
[
[
1064,
25,
1330
],
[
13... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Temozolomide"
]
],
[
[
"Cladribine",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (Side Effect) is caused by {... | Cladribine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Temozolomide (Compound)
Cladribine may lead to a major life threatening interaction when taken with Fluorouracil and Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomi... |
DB00065 | DB01098 | 581 | 14 | [
"DDInter923",
"DDInter1622"
] | Infliximab | Rosuvastatin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
581,
24,
14
]
],
[
[
581,
24,
671
],
[
671,
24,
14
]
],
[
[
581,
24,
1657
],
[
1657,
23,
14
]
],
[
[
581,
24,
517
],
[
517,
62,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Desogestrel and D... |
DB00794 | DB06603 | 759 | 39 | [
"DDInter1521",
"DDInter1387"
] | Primidone | Panobinostat | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
759,
25,
39
]
],
[
[
759,
24,
112
],
[
112,
23,
39
]
],
[
[
759,
24,
272
],
[
272,
24,
39
]
],
[
[
759,
63,
506
],
[
506,
24,
... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine ... |
DB00531 | DB01067 | 450 | 959 | [
"DDInter456",
"DDInter826"
] | Cyclophosphamide | Glipizide | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
450,
24,
959
]
],
[
[
450,
63,
245
],
[
245,
40,
959
]
],
[
[
450,
24,
1411
],
[
1411,
1,
959
]
],
[
[
450,
6,
8374
],
[
8374,
4... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizi... |
DB00321 | DB09065 | 21 | 760 | [
"DDInter78",
"DDInter424"
] | Amitriptyline | Cobicistat | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
21,
24,
760
]
],
[
[
21,
24,
1374
],
[
1374,
23,
760
]
],
[
[
21,
25,
868
],
[
868,
24,
760
]
],
[
[
21,
24,
1033
],
[
1033,
63,... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Amitriptyline may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib ma... |
DB00008 | DB00773 | 491 | 896 | [
"DDInter1407",
"DDInter702"
] | Peginterferon alfa-2a | Etoposide | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
491,
24,
896
]
],
[
[
491,
24,
147
],
[
147,
23,
896
]
],
[
[
491,
24,
700
],
[
700,
63,
896
]
],
[
[
491,
25,
1477
],
[
1477,
6... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinbla... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Etoposide
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00196 | DB00363 | 600 | 695 | [
"DDInter743",
"DDInter419"
] | Fluconazole | Clozapine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
600,
25,
695
]
],
[
[
600,
24,
1178
],
[
1178,
1,
695
]
],
[
[
600,
24,
902
],
[
902,
40,
695
]
],
[
[
600,
6,
10215
],
[
10215,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
"Trif... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Clozapine (Comp... |
DB00005 | DB09389 | 1,057 | 517 | [
"DDInter687",
"DDInter1315"
] | Etanercept | Norgestrel | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1057,
24,
517
]
],
[
[
1057,
24,
14
],
[
14,
23,
517
]
],
[
[
1057,
25,
581
],
[
581,
24,
517
]
],
[
[
1057,
24,
1031
],
[
1031,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Etanercept may lead to a major life threatening interaction when taken with Infliximab and Infliximab may caus... |
DB06754 | DB08816 | 707 | 578 | [
"DDInter471",
"DDInter1802"
] | Danaparoid | Ticagrelor | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
707,
25,
578
]
],
[
[
707,
23,
297
],
[
297,
62,
578
]
],
[
[
707,
64,
1578
],
[
1578,
24,
578
]
],
[
[
707,
63,
757
],
[
757,
2... | [
[
[
"Danaparoid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Danaparoid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u... | Danaparoid may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Danaparoid may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate inter... |
DB00059 | DB00331 | 1,560 | 1,645 | [
"DDInter1404",
"DDInter1164"
] | Pegaspargase | Metformin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Moderate | 1 | [
[
[
1560,
24,
1645
]
],
[
[
1560,
24,
1647
],
[
1647,
23,
1645
]
],
[
[
1560,
24,
1296
],
[
1296,
63,
1645
]
],
[
[
1560,
63,
1179
],
[
11... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Metformin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Ins... |
DB00262 | DB09054 | 552 | 384 | [
"DDInter302",
"DDInter905"
] | Carmustine | Idelalisib | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
552,
24,
384
]
],
[
[
552,
24,
1627
],
[
1627,
62,
384
]
],
[
[
552,
24,
328
],
[
328,
24,
384
]
],
[
[
552,
63,
58
],
[
58,
24,... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Me... |
DB01005 | DB15091 | 995 | 676 | [
"DDInter894",
"DDInter1901"
] | Hydroxyurea | Upadacitinib | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
995,
25,
676
]
],
[
[
995,
63,
1461
],
[
1461,
23,
676
]
],
[
[
995,
24,
1430
],
[
1430,
24,
676
]
],
[
[
995,
63,
563
],
[
563,
... | [
[
[
"Hydroxyurea",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipu... |
DB04868 | DB11110 | 478 | 603 | [
"DDInter1293",
"DDInter1115"
] | Nilotinib | Magnesium citrate | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
478,
24,
603
]
],
[
[
478,
64,
57
],
[
57,
24,
603
]
],
[
[
478,
25,
1616
],
[
1616,
24,
603
]
],
[
[
478,
63,
870
],
[
870,
24,... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Nilotinib may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Nilotinib may lead to a major life threatening interaction when taken with Histrelin and Histrelin may cause ... |
DB08880 | DB12834 | 1,510 | 148 | [
"DDInter1771",
"DDInter1649"
] | Teriflunomide | Secnidazole | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1510,
24,
148
]
],
[
[
1510,
64,
1593
],
[
1593,
24,
148
]
],
[
[
1510,
25,
1480
],
[
1480,
24,
148
]
],
[
[
1510,
24,
1434
],
[
1434,... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Cri... | Teriflunomide may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Teriflunomide may lead to a major life threatening interaction when taken with Ixazomib and Ixazomib may cause a moderate i... |
DB00247 | DB00400 | 1,131 | 353 | [
"DDInter1194",
"DDInter843"
] | Methysergide | Griseofulvin | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Moderate | 1 | [
[
[
1131,
24,
353
]
],
[
[
1131,
21,
29093
],
[
29093,
60,
353
]
],
[
[
1131,
24,
1101
],
[
1101,
23,
353
]
],
[
[
1131,
40,
628
],
[
628,... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
]
],
[
[
"Methysergide",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is ca... | Methysergide (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Griseofulvin (Compound)
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Griseof... |
DB01229 | DB09498 | 973 | 810 | [
"DDInter1377",
"DDInter1715"
] | Paclitaxel | Strontium chloride Sr-89 | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
973,
24,
810
]
],
[
[
973,
63,
1555
],
[
1555,
24,
810
]
],
[
[
973,
24,
1060
],
[
1060,
63,
810
]
],
[
[
973,
24,
310
],
[
310,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Enfor... |
DB00959 | DB11952 | 1,486 | 800 | [
"DDInter1191",
"DDInter612"
] | Methylprednisolone | Duvelisib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1486,
24,
800
]
],
[
[
1486,
63,
663
],
[
663,
24,
800
]
],
[
[
1486,
24,
270
],
[
270,
63,
800
]
],
[
[
1486,
24,
1683
],
[
1683,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Oc... |
DB01177 | DB06636 | 77 | 1,623 | [
"DDInter904",
"DDInter980"
] | Idarubicin | Isavuconazonium | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
77,
24,
1623
]
],
[
[
77,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
77,
25,
1487
],
[
1487,
24,
1623
]
],
[
[
77,
24,
1213
],
[
1213,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Idarubicin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychlor... |
DB04855 | DB06772 | 540 | 310 | [
"DDInter602",
"DDInter259"
] | Dronedarone | Cabazitaxel | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
540,
24,
310
]
],
[
[
540,
63,
973
],
[
973,
24,
310
]
],
[
[
540,
6,
4973
],
[
4973,
45,
310
]
],
[
[
540,
21,
28894
],
[
28894,
... | [
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Dronedarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cabazitaxel (Compound)
Dronedarone (Com... |
DB00405 | DB01036 | 128 | 211 | [
"DDInter517",
"DDInter1832"
] | Dexbrompheniramine | Tolterodine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Moderate | 1 | [
[
[
128,
24,
211
]
],
[
[
128,
24,
358
],
[
358,
40,
211
]
],
[
[
128,
40,
11296
],
[
11296,
40,
211
]
],
[
[
128,
40,
11244
],
[
11244,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadri... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Tolterodine (Compound)
Dexbrompheniramine (Compound) resembles Bromodiphenhydramine (Compound) and Bromodiphenhydramine (Compound) resembles Tolterodine (Compound)
Dexbro... |
DB00047 | DB01208 | 176 | 945 | [
"DDInter932",
"DDInter1705"
] | Insulin glargine | Sparfloxacin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
176,
25,
945
]
],
[
[
176,
25,
739
],
[
739,
1,
945
]
],
[
[
176,
24,
1002
],
[
1002,
63,
945
]
],
[
[
176,
24,
688
],
[
688,
24... | [
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxa... | Insulin glargine may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin may cause a moderate interaction that co... |
DB00704 | DB01185 | 267 | 155 | [
"DDInter1263",
"DDInter759"
] | Naltrexone | Fluoxymesterone | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Moderate | 1 | [
[
[
267,
24,
155
]
],
[
[
267,
24,
1546
],
[
1546,
40,
155
]
],
[
[
267,
63,
1561
],
[
1561,
40,
155
]
],
[
[
267,
21,
29600
],
[
29600,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Fluoxymesterone (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resembl... |
DB01118 | DB01259 | 33 | 392 | [
"DDInter76",
"DDInter1024"
] | Amiodarone | Lapatinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
33,
25,
392
]
],
[
[
33,
6,
4973
],
[
4973,
45,
392
]
],
[
[
33,
7,
3727
],
[
3727,
46,
392
]
],
[
[
33,
18,
15501
],
[
15501,
5... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapatinib"... | Amiodarone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Amiodarone (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Amiodarone (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Lapatinib (Compound)
Amiodarone (Compound)... |
DB00563 | DB01202 | 663 | 1,435 | [
"DDInter1174",
"DDInter1046"
] | Methotrexate | Levetiracetam | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Minor | 0 | [
[
[
663,
23,
1435
]
],
[
[
663,
6,
4973
],
[
4973,
45,
1435
]
],
[
[
663,
18,
6929
],
[
6929,
57,
1435
]
],
[
[
663,
21,
28769
],
[
28769,... | [
[
[
"Methotrexate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levetiracetam"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound... | Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levetiracetam (Compound)
Methotrexate (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Levetiracetam (Compound)
Methotrexate (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by ... |
DB00030 | DB01278 | 1,685 | 1,021 | [
"DDInter934",
"DDInter1506"
] | Insulin human | Pramlintide | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1685,
24,
1021
]
],
[
[
1685,
23,
1103
],
[
1103,
23,
1021
]
],
[
[
1685,
24,
1560
],
[
1560,
24,
1021
]
],
[
[
1685,
25,
1539
],
[
15... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Insulin human",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin human may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Pramlintide
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and P... |
DB00286 | DB12500 | 380 | 283 | [
"DDInter439",
"DDInter714"
] | Conjugated estrogens | Fedratinib | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
380,
24,
283
]
],
[
[
380,
24,
1419
],
[
1419,
24,
283
]
],
[
[
380,
63,
600
],
[
600,
24,
283
]
],
[
[
380,
40,
559
],
[
559,
2... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatini... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Fluco... |
DB00227 | DB01110 | 1,463 | 86 | [
"DDInter1098",
"DDInter1209"
] | Lovastatin | Miconazole | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
1463,
24,
86
]
],
[
[
1463,
6,
10215
],
[
10215,
45,
86
]
],
[
[
1463,
18,
2183
],
[
2183,
57,
86
]
],
[
[
1463,
21,
29081
],
[
29081,... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Lovastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)... | Lovastatin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Lovastatin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Lovastatin (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Miconazole (Compound... |
DB04908 | DB08916 | 1,671 | 26 | [
"DDInter741",
"DDInter32"
] | Flibanserin | Afatinib | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
1671,
24,
26
]
],
[
[
1671,
24,
1320
],
[
1320,
63,
26
]
],
[
[
1671,
25,
129
],
[
129,
24,
26
]
],
[
[
1671,
64,
609
],
[
609,
... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Afatinib
Flibanserin may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause ... |
DB09098 | DB11613 | 98 | 1,519 | [
"DDInter1700",
"DDInter1924"
] | Somatrem | Velpatasvir | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
98,
24,
1519
]
],
[
[
98,
63,
1135
],
[
1135,
23,
1519
]
],
[
[
98,
63,
1374
],
[
1374,
24,
1519
]
],
[
[
98,
24,
351
],
[
351,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Velpatasvir"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Velpatasvir
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone ... |
DB00831 | DB01268 | 1,178 | 1,151 | [
"DDInter1866",
"DDInter1731"
] | Trifluoperazine | Sunitinib | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1178,
24,
1151
]
],
[
[
1178,
25,
1311
],
[
1311,
1,
1151
]
],
[
[
1178,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
1178,
7,
9650
],
[
9650,... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
... | Trifluoperazine may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Trifluoperazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Trifluoperazine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Ge... |
DB00620 | DB01359 | 175 | 729 | [
"DDInter1855",
"DDInter1417"
] | Triamcinolone | Penbutolol | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
175,
24,
729
]
],
[
[
175,
63,
461
],
[
461,
1,
729
]
],
[
[
175,
24,
699
],
[
699,
40,
729
]
],
[
[
175,
21,
28698
],
[
28698,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Triamc... |
DB00694 | DB01236 | 51 | 679 | [
"DDInter485",
"DDInter1664"
] | Daunorubicin | Sevoflurane | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Moderate | 1 | [
[
[
51,
24,
679
]
],
[
[
51,
63,
1262
],
[
1262,
40,
679
]
],
[
[
51,
6,
8374
],
[
8374,
45,
679
]
],
[
[
51,
7,
15554
],
[
15554,
4... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) resembles Sevoflurane (Compound)
Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sevoflurane (Compound)
Daunorubicin (Compound) upregulates ATP2C1 (Gene) and ATP2C1... |
DB00443 | DB11988 | 251 | 270 | [
"DDInter195",
"DDInter1321"
] | Betamethasone | Ocrelizumab | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
251,
24,
270
]
],
[
[
251,
23,
1193
],
[
1193,
23,
270
]
],
[
[
251,
62,
1461
],
[
1461,
23,
270
]
],
[
[
251,
24,
713
],
[
713,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Betamethasone may cause a minor interaction that can limit clinical effects when taken with Vitamin E an... |
DB00557 | DB01409 | 252 | 1,415 | [
"DDInter895",
"DDInter1815"
] | Hydroxyzine | Tiotropium | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
252,
24,
1415
]
],
[
[
252,
6,
12523
],
[
12523,
45,
1415
]
],
[
[
252,
21,
28680
],
[
28680,
60,
1415
]
],
[
[
252,
62,
752
],
[
752,... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Hydroxyzine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tiotropium (Compound)
Hydroxyzine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Tiotropium (Compound)
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine ma... |
DB04861 | DB09333 | 1,592 | 278 | [
"DDInter1271",
"DDInter963"
] | Nebivolol | Iopodic acid | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque property. It was devel... | Moderate | 1 | [
[
[
1592,
24,
278
]
],
[
[
1592,
63,
1648
],
[
1648,
24,
278
]
],
[
[
1592,
24,
1527
],
[
1527,
24,
278
]
],
[
[
1592,
63,
1648
],
[
1648,... | [
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
]
],
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid and... |
DB00999 | DB09112 | 504 | 1,455 | [
"DDInter883",
"DDInter1306"
] | Hydrochlorothiazide | Nitrous acid | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
504,
24,
1455
]
],
[
[
504,
1,
674
],
[
674,
24,
1455
]
],
[
[
504,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
504,
40,
178
],
[
178,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Hydrochlorothiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiaz... | Hydrochlorothiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin m... |
DB00009 | DB01197 | 1,271 | 1,603 | [
"DDInter56",
"DDInter292"
] | Alteplase | Captopril | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1271,
24,
1603
]
],
[
[
1271,
24,
610
],
[
610,
1,
1603
]
],
[
[
1271,
24,
1061
],
[
1061,
24,
1603
]
],
[
[
1271,
25,
802
],
[
802,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could ... |
DB00427 | DB00497 | 1,233 | 828 | [
"DDInter1879",
"DDInter1366"
] | Triprolidine | Oxycodone | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
1233,
24,
828
]
],
[
[
1233,
63,
421
],
[
421,
1,
828
]
],
[
[
1233,
24,
314
],
[
314,
1,
828
]
],
[
[
1233,
24,
560
],
[
560,
4... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Oxycodone (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxycodone (Co... |
DB00445 | DB12332 | 322 | 1,619 | [
"DDInter655",
"DDInter1626"
] | Epirubicin | Rucaparib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
322,
24,
1619
]
],
[
[
322,
23,
112
],
[
112,
23,
1619
]
],
[
[
322,
24,
259
],
[
259,
24,
1619
]
],
[
[
322,
24,
151
],
[
151,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilon... |
DB06441 | DB10897 | 936 | 539 | [
"DDInter283",
"DDInter291"
] | Cangrelor | Capsicum | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
936,
23,
539
]
],
[
[
936,
63,
885
],
[
885,
23,
539
]
],
[
[
936,
64,
1018
],
[
1018,
23,
539
]
],
[
[
936,
25,
840
],
[
840,
2... | [
[
[
"Cangrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Cangrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Cangrelor may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Cangrelor may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine may cause ... |
DB00938 | DB11986 | 455 | 484 | [
"DDInter1635",
"DDInter648"
] | Salmeterol | Entrectinib | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
455,
24,
484
]
],
[
[
455,
24,
222
],
[
222,
23,
484
]
],
[
[
455,
24,
1539
],
[
1539,
24,
484
]
],
[
[
455,
63,
1674
],
[
1674,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxa... |
DB01206 | DB09122 | 37 | 1,613 | [
"DDInter1086",
"DDInter1409"
] | Lomustine | Peginterferon beta-1a | An alkylating agent of value against both hematologic malignancies and solid tumors. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
37,
24,
1613
]
],
[
[
37,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
37,
24,
975
],
[
975,
63,
1613
]
],
[
[
37,
62,
1176
],
[
1176,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinecte... |
DB00374 | DB00461 | 1,061 | 598 | [
"DDInter1852",
"DDInter1254"
] | Treprostinil | Nabumetone | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Moderate | 1 | [
[
[
1061,
24,
598
]
],
[
[
1061,
7,
7720
],
[
7720,
45,
598
]
],
[
[
1061,
21,
28703
],
[
28703,
60,
598
]
],
[
[
1061,
63,
1271
],
[
1271... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabumetone"
]
],
[
[
"Treprostinil",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Com... | Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Nabumetone (Compound)
Treprostinil (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Nabumetone (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Alteplase a... |
DB00783 | DB00860 | 1,438 | 891 | [
"DDInter679",
"DDInter1513"
] | Estradiol | Prednisolone | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1438,
24,
891
]
],
[
[
1438,
63,
175
],
[
175,
40,
891
]
],
[
[
1438,
24,
1547
],
[
1547,
1,
891
]
],
[
[
1438,
1,
1561
],
[
1561,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Exemestane and Exemestane (Compound) resembles Prednisolone (Co... |
DB00855 | DB05294 | 213 | 1,069 | [
"DDInter72",
"DDInter1917"
] | Aminolevulinic acid | Vandetanib | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
213,
25,
1069
]
],
[
[
213,
64,
1195
],
[
1195,
40,
1069
]
],
[
[
213,
21,
28719
],
[
28719,
60,
1069
]
],
[
[
213,
25,
1247
],
[
1247... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erlotinib"
],
[
"Erlotini... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Aminolevulinic acid (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Aminolevulinic acid may lead to a major life threaten... |
DB01208 | DB11837 | 945 | 1,297 | [
"DDInter1705",
"DDInter1351"
] | Sparfloxacin | Osilodrostat | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
945,
25,
1297
]
],
[
[
945,
62,
112
],
[
112,
23,
1297
]
],
[
[
945,
64,
401
],
[
401,
24,
1297
]
],
[
[
945,
24,
657
],
[
657,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Sparfloxacin may lead to a major life threatening interaction when taken with Promethazine and Promethazin... |
DB00983 | DB01285 | 480 | 708 | [
"DDInter776",
"DDInter445"
] | Formoterol | Corticotropin | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Minor | 0 | [
[
[
480,
23,
708
]
],
[
[
480,
63,
455
],
[
455,
23,
708
]
],
[
[
480,
24,
659
],
[
659,
62,
708
]
],
[
[
480,
74,
1052
],
[
1052,
2... | [
[
[
"Formoterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Corticotropin"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilan... |
DB00005 | DB06616 | 1,057 | 594 | [
"DDInter687",
"DDInter224"
] | Etanercept | Bosutinib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1057,
25,
594
]
],
[
[
1057,
24,
112
],
[
112,
23,
594
]
],
[
[
1057,
25,
713
],
[
713,
63,
594
]
],
[
[
1057,
25,
663
],
[
663,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bosutinib
Etanercept may lead to a major life threatening interaction when taken with Dimethyl fumarate and Dimethyl fu... |
DB00108 | DB00563 | 1,066 | 663 | [
"DDInter1268",
"DDInter1174"
] | Natalizumab | Methotrexate | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Major | 2 | [
[
[
1066,
25,
663
]
],
[
[
1066,
25,
328
],
[
328,
62,
663
]
],
[
[
1066,
25,
738
],
[
738,
63,
663
]
],
[
[
1066,
24,
949
],
[
949,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mercaptopurine"
],
[
"Mercaptopurine",
... | Natalizumab may lead to a major life threatening interaction when taken with Mercaptopurine and Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Natalizumab may lead to a major life threatening interaction when taken with Niraparib and Niraparib may cause a moder... |
DB00721 | DB09112 | 1,207 | 1,455 | [
"DDInter1525",
"DDInter1306"
] | Procaine | Nitrous acid | A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-expe... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
1207,
25,
1455
]
],
[
[
1207,
1,
1311
],
[
1311,
25,
1455
]
],
[
[
1207,
24,
50
],
[
50,
25,
1455
]
],
[
[
1207,
1,
1311
],
[
1311,
... | [
[
[
"Procaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Procaine",
"{u} (Compound) resembles {v} (Compound)",
"Metoclopramide"
],
[
"Metoclopramide",
"{u} may lead to a major life thr... | Procaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Nitrous acid
Procaine may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may lead to a major life threatening interacti... |
DB00712 | DB00999 | 1,274 | 504 | [
"DDInter763",
"DDInter883"
] | Flurbiprofen | Hydrochlorothiazide | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
1274,
24,
504
]
],
[
[
1274,
24,
178
],
[
178,
1,
504
]
],
[
[
1274,
63,
323
],
[
323,
40,
504
]
],
[
[
1274,
24,
359
],
[
359,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Compoun... |
DB00285 | DB06764 | 1,100 | 1,090 | [
"DDInter1927",
"DDInter1788"
] | Venlafaxine | Tetryzoline (ophthalmic) | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
1100,
24,
1090
]
],
[
[
1100,
24,
144
],
[
144,
63,
1090
]
],
[
[
1100,
24,
688
],
[
688,
24,
1090
]
],
[
[
1100,
1,
643
],
[
643,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
[... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Venlaf... |
DB00030 | DB00363 | 1,685 | 695 | [
"DDInter934",
"DDInter419"
] | Insulin human | Clozapine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Moderate | 1 | [
[
[
1685,
24,
695
]
],
[
[
1685,
24,
1178
],
[
1178,
1,
695
]
],
[
[
1685,
24,
623
],
[
623,
40,
695
]
],
[
[
1685,
23,
274
],
[
274,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Clozapi... |
DB00214 | DB00621 | 1,028 | 1,026 | [
"DDInter1836",
"DDInter1357"
] | Torasemide | Oxandrolone | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
1028,
24,
1026
]
],
[
[
1028,
21,
29956
],
[
29956,
60,
1026
]
],
[
[
1028,
24,
473
],
[
473,
63,
1026
]
],
[
[
1028,
63,
1685
],
[
16... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Torasemide",
"{u} (Compound) causes {v} (Side Effect)",
"Erectile dysfunction"
],
[
"Erectile dysfunction",
"{u... | Torasemide (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Oxandrolone (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate disease... |
DB01211 | DB08912 | 609 | 1,040 | [
"DDInter393",
"DDInter462"
] | Clarithromycin | Dabrafenib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
609,
24,
1040
]
],
[
[
609,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
609,
7,
3466
],
[
3466,
46,
1040
]
],
[
[
609,
18,
7247
],
[
7247,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compo... | Clarithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Clarithromycin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Dabrafenib (Compound)
Clarithromycin (Compound) downregulates NPDC1 (Gene) and NPDC1 (Gene) is upregulated by Dabrafenib (Compound)
Clarit... |
DB01129 | DB12500 | 379 | 283 | [
"DDInter1559",
"DDInter714"
] | Rabeprazole | Fedratinib | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
379,
24,
283
]
],
[
[
379,
24,
1580
],
[
1580,
24,
283
]
],
[
[
379,
63,
600
],
[
600,
24,
283
]
],
[
[
379,
23,
785
],
[
785,
2... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
],
[... | Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol and Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and F... |
DB09080 | DB11718 | 144 | 927 | [
"DDInter1331",
"DDInter640"
] | Olodaterol | Encorafenib | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
144,
24,
927
]
],
[
[
144,
62,
1247
],
[
1247,
23,
927
]
],
[
[
144,
63,
216
],
[
216,
24,
927
]
],
[
[
144,
24,
659
],
[
659,
2... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Olodaterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Olodaterol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazi... |
DB00005 | DB06688 | 1,057 | 1,430 | [
"DDInter687",
"DDInter1677"
] | Etanercept | Sipuleucel-T | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
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[
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[
676,
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[
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1057,
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],
[
491,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triam... | Etanercept may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Etanercept may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a m... |
DB00197 | DB11689 | 1,324 | 321 | [
"DDInter1881",
"DDInter1659"
] | Troglitazone | Selumetinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
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1324,
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[
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],
[
392,
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[
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[
1297,
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]
],
[
[
1324,
23,
1101
],
[
1101,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and O... |
DB00370 | DB06704 | 1,251 | 247 | [
"DDInter1230",
"DDInter951"
] | Mirtazapine | Iobenguane (I-123) | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
1251,
37,
247
]
],
[
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],
[
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[
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]
],
[
[
1251,
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820
],
[
820,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"SLC6... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Mirtazapine may lead to a major life threatening interaction when taken with Iobenguane
Mirtazapine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Mirtazapine (Compound) causes ... |
DB00197 | DB06228 | 1,324 | 792 | [
"DDInter1881",
"DDInter1609"
] | Troglitazone | Rivaroxaban | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1324,
24,
792
]
],
[
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1324,
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],
[
1631,
62,
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]
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[
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1324,
24,
307
],
[
307,
23,
792
]
],
[
[
1324,
24,
1412
],
[
1412,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Turmeric"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafini... |
DB01227 | DB11837 | 1,301 | 1,297 | [
"DDInter1043",
"DDInter1351"
] | Levacetylmethadol | Osilodrostat | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1301,
25,
1297
]
],
[
[
1301,
62,
112
],
[
112,
23,
1297
]
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[
[
1301,
63,
222
],
[
222,
23,
1297
]
],
[
[
1301,
25,
1320
],
[
1320,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Levacetylmethadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Levacetylmethadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Sib... |
DB00681 | DB00734 | 1,287 | 1,664 | [
"DDInter85",
"DDInter1605"
] | Amphotericin B | Risperidone | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
1287,
24,
1664
]
],
[
[
1287,
24,
519
],
[
519,
40,
1664
]
],
[
[
1287,
21,
28787
],
[
28787,
60,
1664
]
],
[
[
1287,
24,
1042
],
[
10... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Risperidone (Compound)
Amphotericin B (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Risperidone (Compound)
Amphotericin B may cause a m... |
DB00604 | DB00771 | 1,425 | 262 | [
"DDInter385",
"DDInter397"
] | Cisapride | Clidinium | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
1425,
24,
262
]
],
[
[
1425,
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],
[
1511,
63,
262
]
],
[
[
1425,
64,
323
],
[
323,
23,
262
]
],
[
[
1425,
25,
504
],
[
504,
... | [
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Cisapride may lead to a major life threatening interaction when taken with Bendroflumethiazide and Bendroflumeth... |
DB00586 | DB12887 | 1,512 | 1,598 | [
"DDInter537",
"DDInter1750"
] | Diclofenac | Tazemetostat | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
1512,
24,
1598
]
],
[
[
1512,
24,
738
],
[
738,
24,
1598
]
],
[
[
1512,
62,
752
],
[
752,
24,
1598
]
],
[
[
1512,
63,
121
],
[
121,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidi... |
DB01044 | DB01211 | 246 | 609 | [
"DDInter809",
"DDInter393"
] | Gatifloxacin | Clarithromycin | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
246,
25,
609
]
],
[
[
246,
7,
4904
],
[
4904,
46,
609
]
],
[
[
246,
18,
4360
],
[
4360,
57,
609
]
],
[
[
246,
21,
28662
],
[
28662,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) upregulates {v} (Gene)",
"CNOT4"
],
[
"CNOT4",
"{u} (Gene) is upregulated by {v} (Compound... | Gatifloxacin (Compound) upregulates CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Clarithromycin (Compound)
Gatifloxacin (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Clarithromycin (Compound)
Gatifloxacin (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarit... |
DB00835 | DB01181 | 100 | 1,532 | [
"DDInter245",
"DDInter906"
] | Brompheniramine | Ifosfamide | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
100,
24,
1532
]
],
[
[
100,
6,
3486
],
[
3486,
45,
1532
]
],
[
[
100,
63,
684
],
[
684,
24,
1532
]
],
[
[
100,
24,
481
],
[
481,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Brompheniramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (C... | Brompheniramine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ifosfamide (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Brom... |
DB14568 | DB14881 | 982 | 180 | [
"DDInter1000",
"DDInter1329"
] | Ivosidenib | Oliceridine | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
982,
25,
180
]
],
[
[
982,
62,
112
],
[
112,
23,
180
]
],
[
[
982,
64,
401
],
[
401,
24,
180
]
],
[
[
982,
63,
578
],
[
578,
24,... | [
[
[
"Ivosidenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Ivosidenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Ivosidenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Ivosidenib may lead to a major life threatening interaction when taken with Promethazine and Promethazine may... |
DB01215 | DB04868 | 1,418 | 478 | [
"DDInter677",
"DDInter1293"
] | Estazolam | Nilotinib | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1418,
24,
478
]
],
[
[
1418,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1418,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1418,
24,
1040
],
[
1040... | [
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Estazolam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Estazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Estazolam (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib ma... |
DB06788 | DB11837 | 1,616 | 1,297 | [
"DDInter864",
"DDInter1351"
] | Histrelin | Osilodrostat | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1616,
24,
1297
]
],
[
[
1616,
62,
112
],
[
112,
23,
1297
]
],
[
[
1616,
63,
623
],
[
623,
24,
1297
]
],
[
[
1616,
24,
657
],
[
657,
... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Histrelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Histrelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quet... |
DB06228 | DB09079 | 792 | 1,496 | [
"DDInter1609",
"DDInter1296"
] | Rivaroxaban | Nintedanib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
792,
24,
1496
]
],
[
[
792,
25,
707
],
[
707,
24,
1496
]
],
[
[
792,
63,
33
],
[
33,
24,
1496
]
],
[
[
792,
24,
741
],
[
741,
63... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparo... | Rivaroxaban may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may caus... |
DB01166 | DB01169 | 477 | 57 | [
"DDInter379",
"DDInter120"
] | Cilostazol | Arsenic trioxide | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
477,
25,
57
]
],
[
[
477,
6,
8374
],
[
8374,
45,
57
]
],
[
[
477,
62,
1247
],
[
1247,
23,
57
]
],
[
[
477,
24,
603
],
[
603,
63,... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"A... | Cilostazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Cilostazol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxid... |
DB00775 | DB00975 | 1,226 | 1,317 | [
"DDInter1818",
"DDInter573"
] | Tirofiban | Dipyridamole | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Major | 2 | [
[
[
1226,
25,
1317
]
],
[
[
1226,
5,
11576
],
[
11576,
49,
1317
]
],
[
[
1226,
54,
19166
],
[
19166,
15,
1317
]
],
[
[
1226,
21,
28778
],
[
... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dipyridamole"
]
],
[
[
"Tirofiban",
"{u} (Compound) treats {v} (Disease)",
"coronary artery disease"
],
[
"coronary artery disease",
"{u} (Disease) is... | Tirofiban (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is palliated by Dipyridamole (Compound)
Tirofiban (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class) and Decreased Platelet Aggregation (Pharmacologic Class) includes Dipyridamole (Compound)
T... |
DB00601 | DB11130 | 453 | 407 | [
"DDInter1073",
"DDInter1344"
] | Linezolid | Opium | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Major | 2 | [
[
[
453,
25,
407
]
],
[
[
453,
24,
662
],
[
662,
24,
407
]
],
[
[
453,
25,
976
],
[
976,
24,
407
]
],
[
[
453,
63,
1233
],
[
1233,
2... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Opium"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
"Carbinoxamine"... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Linezolid may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause... |
DB09039 | DB11581 | 1,670 | 1,456 | [
"DDInter629",
"DDInter1926"
] | Eliglustat | Venetoclax | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1670,
25,
1456
]
],
[
[
1670,
23,
1135
],
[
1135,
23,
1456
]
],
[
[
1670,
63,
536
],
[
536,
24,
1456
]
],
[
[
1670,
24,
241
],
[
241,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Eliglustat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Eliglustat may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbit... |
DB01017 | DB01339 | 1,669 | 728 | [
"DDInter1224",
"DDInter1922"
] | Minocycline | Vecuronium | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide ad... | Moderate | 1 | [
[
[
1669,
24,
728
]
],
[
[
1669,
63,
1610
],
[
1610,
1,
728
]
],
[
[
1669,
24,
1579
],
[
1579,
40,
728
]
],
[
[
1669,
40,
1620
],
[
1620,
... | [
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vecuronium"
]
],
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
],
[
... | Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Vecuronium (Compound)
Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium and Pancuronium (Compound) resembles Vecuronium (Compou... |
DB00250 | DB12825 | 10 | 1,375 | [
"DDInter475",
"DDInter1032"
] | Dapsone | Lefamulin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
10,
24,
1375
]
],
[
[
10,
24,
112
],
[
112,
23,
1375
]
],
[
[
10,
24,
309
],
[
309,
24,
1375
]
],
[
[
10,
63,
1324
],
[
1324,
24... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepil... |
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