drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00261 | DB00407 | 702 | 202 | [
"DDInter93",
"DDInter115"
] | Anagrelide | Ardeparin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Major | 2 | [
[
[
702,
25,
202
]
],
[
[
702,
21,
28708
],
[
28708,
60,
202
]
],
[
[
702,
24,
738
],
[
738,
63,
202
]
],
[
[
702,
25,
1151
],
[
1151,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ardeparin"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Malaise"
],
[
"Malaise",
"{u} (Side Effect) is caused by {v} (Compound)... | Anagrelide (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Ardeparin (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Ardeparin
Anag... |
DB00220 | DB08896 | 798 | 292 | [
"DDInter1276",
"DDInter1576"
] | Nelfinavir | Regorafenib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
798,
24,
292
]
],
[
[
798,
6,
6017
],
[
6017,
45,
292
]
],
[
[
798,
21,
29276
],
[
29276,
60,
292
]
],
[
[
798,
24,
549
],
[
549,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Nelfinavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Nelfinavir (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Regorafenib (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin... |
DB00384 | DB00762 | 1,275 | 613 | [
"DDInter1859",
"DDInter973"
] | Triamterene | Irinotecan | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
1275,
24,
613
]
],
[
[
1275,
7,
7720
],
[
7720,
46,
613
]
],
[
[
1275,
18,
4168
],
[
4168,
57,
613
]
],
[
[
1275,
21,
28658
],
[
28658... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Triamterene",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v} ... | Triamterene (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Irinotecan (Compound)
Triamterene (Compound) downregulates PEG10 (Gene) and PEG10 (Gene) is downregulated by Irinotecan (Compound)
Triamterene (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Irinotecan (C... |
DB01085 | DB01409 | 562 | 1,415 | [
"DDInter1465",
"DDInter1815"
] | Pilocarpine | Tiotropium | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
562,
24,
1415
]
],
[
[
562,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
562,
21,
29187
],
[
29187,
60,
1415
]
],
[
[
562,
24,
1116
],
[
1116,... | [
[
[
"Pilocarpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Pilocarpine",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compound)",... | Pilocarpine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Pilocarpine (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Tiotropium (Compound)
Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium and Ume... |
DB00618 | DB08827 | 1,572 | 990 | [
"DDInter498",
"DDInter1085"
] | Demeclocycline | Lomitapide | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1572,
25,
990
]
],
[
[
1572,
24,
126
],
[
126,
24,
990
]
],
[
[
1572,
63,
305
],
[
305,
25,
990
]
],
[
[
1572,
1,
1669
],
[
1669,
... | [
[
[
"Demeclocycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
"Warf... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Esch... |
DB01211 | DB13139 | 609 | 1,032 | [
"DDInter393",
"DDInter1063"
] | Clarithromycin | Levosalbutamol | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
609,
24,
1032
]
],
[
[
609,
63,
1573
],
[
1573,
23,
1032
]
],
[
[
609,
64,
1486
],
[
1486,
23,
1032
]
],
[
[
609,
24,
1220
],
[
1220,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Clarithromycin may lead to a major life threatening interaction when taken with Methylprednisolone and Met... |
DB04845 | DB12834 | 309 | 148 | [
"DDInter1001",
"DDInter1649"
] | Ixabepilone | Secnidazole | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
309,
24,
148
]
],
[
[
309,
24,
1593
],
[
1593,
24,
148
]
],
[
[
309,
63,
1191
],
[
1191,
24,
148
]
],
[
[
309,
25,
1510
],
[
1510,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levod... |
DB02701 | DB06203 | 1,632 | 1,002 | [
"DDInter1289",
"DDInter51"
] | Nicotinamide | Alogliptin | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1632,
24,
1002
]
],
[
[
1632,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1632,
63,
176
],
[
176,
24,
1002
]
],
[
[
1632,
24,
1412
],
[
1412... | [
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate inte... |
DB00609 | DB08901 | 595 | 1,468 | [
"DDInter694",
"DDInter1492"
] | Ethionamide | Ponatinib | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
595,
24,
1468
]
],
[
[
595,
7,
16981
],
[
16981,
46,
1468
]
],
[
[
595,
18,
4360
],
[
4360,
57,
1468
]
],
[
[
595,
21,
28722
],
[
2872... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Ethionamide",
"{u} (Compound) upregulates {v} (Gene)",
"ZNF586"
],
[
"ZNF586",
"{u} (Gene) is upregulated by {v}... | Ethionamide (Compound) upregulates ZNF586 (Gene) and ZNF586 (Gene) is upregulated by Ponatinib (Compound)
Ethionamide (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Ponatinib (Compound)
Ethionamide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ponatinib (Compou... |
DB01087 | DB01155 | 1,520 | 872 | [
"DDInter1520",
"DDInter813"
] | Primaquine | Gemifloxacin | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1520,
24,
872
]
],
[
[
1520,
63,
739
],
[
739,
1,
872
]
],
[
[
1520,
25,
945
],
[
945,
40,
872
]
],
[
[
1520,
64,
1176
],
[
1176,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Primaquine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gemifloxacin (Compound)
Pri... |
DB06616 | DB11988 | 594 | 270 | [
"DDInter224",
"DDInter1321"
] | Bosutinib | Ocrelizumab | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
594,
24,
270
]
],
[
[
594,
63,
1491
],
[
1491,
24,
270
]
],
[
[
594,
24,
1456
],
[
1456,
24,
270
]
],
[
[
594,
25,
800
],
[
800,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venet... |
DB00321 | DB00983 | 21 | 480 | [
"DDInter78",
"DDInter776"
] | Amitriptyline | Formoterol | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
21,
24,
480
]
],
[
[
21,
24,
1148
],
[
1148,
63,
480
]
],
[
[
21,
6,
6017
],
[
6017,
45,
480
]
],
[
[
21,
21,
28963
],
[
28963,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Amitriptyline (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Formoterol (Compound)
Amitript... |
DB01143 | DB01244 | 923 | 762 | [
"DDInter65",
"DDInter192"
] | Amifostine | Bepridil | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
923,
24,
762
]
],
[
[
923,
63,
601
],
[
601,
40,
762
]
],
[
[
923,
21,
28789
],
[
28789,
60,
762
]
],
[
[
923,
63,
1061
],
[
1061,
... | [
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethaphan"
],
[
... | Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Trimethaphan and Trimethaphan (Compound) resembles Bepridil (Compound)
Amifostine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Bepridil (Compound)
Amifostine may cause... |
DB00661 | DB01211 | 122 | 609 | [
"DDInter1928",
"DDInter393"
] | Verapamil | Clarithromycin | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
122,
24,
609
]
],
[
[
122,
6,
4973
],
[
4973,
45,
609
]
],
[
[
122,
7,
4904
],
[
4904,
46,
609
]
],
[
[
122,
18,
3106
],
[
3106,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Verapamil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Verapamil (Compound) upregulates CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Clarithromycin (Compound)
Verapamil (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Clarithromycin (Compound)
Verap... |
DB00749 | DB06822 | 59 | 802 | [
"DDInter699",
"DDInter1812"
] | Etodolac | Tinzaparin | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
59,
25,
802
]
],
[
[
59,
24,
222
],
[
222,
24,
802
]
],
[
[
59,
24,
738
],
[
738,
63,
802
]
],
[
[
59,
63,
121
],
[
121,
24,
... | [
[
[
"Etodolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib... |
DB00620 | DB00814 | 175 | 1,171 | [
"DDInter1855",
"DDInter1143"
] | Triamcinolone | Meloxicam | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
175,
24,
1171
]
],
[
[
175,
63,
1027
],
[
1027,
40,
1171
]
],
[
[
175,
6,
8374
],
[
8374,
45,
1171
]
],
[
[
175,
5,
11653
],
[
11653,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Triamcinolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Meloxicam (Compound)
Triamcinolone (Compound) treats systemic lupus erythematosus (Di... |
DB00495 | DB08895 | 139 | 976 | [
"DDInter1961",
"DDInter1825"
] | Zidovudine | Tofacitinib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
139,
25,
976
]
],
[
[
139,
24,
1017
],
[
1017,
63,
976
]
],
[
[
139,
24,
1430
],
[
1430,
24,
976
]
],
[
[
139,
25,
1011
],
[
1011,
... | [
[
[
"Zidovudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorlatini... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sip... |
DB00035 | DB00726 | 1,314 | 1,164 | [
"DDInter507",
"DDInter1876"
] | Desmopressin | Trimipramine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
1314,
24,
1164
]
],
[
[
1314,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
1314,
21,
28809
],
[
28809,
60,
1164
]
],
[
[
1314,
24,
1532
],
[
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Desmopressin (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Trimipramine (Compound)
Desmopressin may cause a moderat... |
DB00015 | DB00682 | 582 | 126 | [
"DDInter1585",
"DDInter1951"
] | Reteplase | Warfarin | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Major | 2 | [
[
[
582,
25,
126
]
],
[
[
582,
23,
944
],
[
944,
62,
126
]
],
[
[
582,
24,
477
],
[
477,
62,
126
]
],
[
[
582,
24,
557
],
[
557,
63,... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Warfarin
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may c... |
DB00545 | DB00747 | 751 | 1,442 | [
"DDInter1548",
"DDInter1647"
] | Pyridostigmine | Scopolamine | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
751,
24,
1442
]
],
[
[
751,
63,
19
],
[
19,
24,
1442
]
],
[
[
751,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
751,
24,
1123
],
[
1123,
... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Pyridostigmine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Sco... |
DB00289 | DB01096 | 847 | 678 | [
"DDInter132",
"DDInter1356"
] | Atomoxetine | Oxamniquine | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Ex... | Moderate | 1 | [
[
[
847,
24,
678
]
],
[
[
847,
6,
12523
],
[
12523,
45,
678
]
],
[
[
847,
40,
211
],
[
211,
23,
678
]
],
[
[
847,
24,
1383
],
[
1383,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Atomoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxamniquine (Compound)
Atomoxetine (Compound) resembles Tolterodine (Compound) and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Oxamniquine
Atomoxetine may cause a moderate interaction that could exacer... |
DB00549 | DB01259 | 522 | 392 | [
"DDInter1955",
"DDInter1024"
] | Zafirlukast | Lapatinib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
522,
24,
392
]
],
[
[
522,
6,
8374
],
[
8374,
45,
392
]
],
[
[
522,
21,
29539
],
[
29539,
60,
392
]
],
[
[
522,
23,
271
],
[
271,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Zafirlukast (Compound) causes Hepatotoxicity (Side Effect) and Hepatotoxicity (Side Effect) is caused by Lapatinib (Compound)
Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Mirabegron... |
DB08816 | DB11130 | 578 | 407 | [
"DDInter1802",
"DDInter1344"
] | Ticagrelor | Opium | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
578,
24,
407
]
],
[
[
578,
62,
409
],
[
409,
24,
407
]
],
[
[
578,
63,
529
],
[
529,
24,
407
]
],
[
[
578,
24,
1580
],
[
1580,
2... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Ticagrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Felodipine"
],
[
"Fe... | Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Felodipine and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine ... |
DB01124 | DB13007 | 1,411 | 1,060 | [
"DDInter1828",
"DDInter642"
] | Tolbutamide | Enfortumab vedotin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1411,
24,
1060
]
],
[
[
1411,
24,
129
],
[
129,
23,
1060
]
],
[
[
1411,
24,
1281
],
[
1281,
24,
1060
]
],
[
[
1411,
63,
1645
],
[
1645... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Linaglipt... |
DB00104 | DB00331 | 966 | 1,645 | [
"DDInter1323",
"DDInter1164"
] | Octreotide | Metformin | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Moderate | 1 | [
[
[
966,
24,
1645
]
],
[
[
966,
21,
28714
],
[
28714,
60,
1645
]
],
[
[
966,
24,
1647
],
[
1647,
23,
1645
]
],
[
[
966,
24,
1296
],
[
1296... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]
],
[
[
"Octreotide",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused ... | Octreotide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metformin (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Metformin
Octreo... |
DB01177 | DB11796 | 77 | 1,612 | [
"DDInter904",
"DDInter786"
] | Idarubicin | Fostemsavir | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
77,
24,
1612
]
],
[
[
77,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
77,
62,
112
],
[
112,
23,
1612
]
],
[
[
77,
63,
1424
],
[
1424,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Idarubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB06372 | DB14409 | 259 | 1,129 | [
"DDInter1594",
"DDInter867"
] | Rilonacept | Human adenovirus e serotype 4 strain cl-68578 antigen | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
259,
24,
1129
]
],
[
[
259,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
259,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
259,
24,
1456
],
[
1456,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Rilonacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Rilonacept may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Rilonacept may cause a moderate interaction that could exacerbate diseases when take... |
DB01234 | DB09104 | 1,220 | 286 | [
"DDInter513",
"DDInter1118"
] | Dexamethasone | Magnesium hydroxide | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1220,
24,
286
]
],
[
[
1220,
24,
1482
],
[
1482,
23,
286
]
],
[
[
1220,
63,
88
],
[
88,
23,
286
]
],
[
[
1220,
62,
1382
],
[
1382,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol... |
DB06317 | DB08865 | 1,626 | 1,593 | [
"DDInter630",
"DDInter448"
] | Elotuzumab | Crizotinib | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1626,
24,
1593
]
],
[
[
1626,
24,
1627
],
[
1627,
62,
1593
]
],
[
[
1626,
24,
1060
],
[
1060,
63,
1593
]
],
[
[
1626,
25,
375
],
[
375... | [
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Crizotinib
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin an... |
DB01222 | DB08908 | 617 | 713 | [
"DDInter246",
"DDInter564"
] | Budesonide | Dimethyl fumarate | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
617,
24,
713
]
],
[
[
617,
24,
4
],
[
4,
24,
713
]
],
[
[
617,
24,
270
],
[
270,
63,
713
]
],
[
[
617,
40,
1220
],
[
1220,
24,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Budesonide may cause a moderate interaction that could exacerbate diseases ... |
DB00065 | DB00322 | 581 | 141 | [
"DDInter923",
"DDInter742"
] | Infliximab | Floxuridine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Major | 2 | [
[
[
581,
25,
141
]
],
[
[
581,
25,
1083
],
[
1083,
40,
141
]
],
[
[
581,
24,
1477
],
[
1477,
40,
141
]
],
[
[
581,
25,
1064
],
[
1064,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Floxuridine"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluridine"
],
[
"Trifluridine",
"... | Infliximab may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine (Compound) resembles Floxuridine (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and Telbivudine (Compound) resembles Floxuridine (Compound)
Inflixi... |
DB00092 | DB01024 | 58 | 1,096 | [
"DDInter40",
"DDInter1252"
] | Alefacept | Mycophenolic acid | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
58,
24,
1096
]
],
[
[
58,
24,
955
],
[
955,
1,
1096
]
],
[
[
58,
23,
1193
],
[
1193,
62,
1096
]
],
[
[
58,
24,
1031
],
[
1031,
2... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause ... |
DB00734 | DB14568 | 1,664 | 982 | [
"DDInter1605",
"DDInter1000"
] | Risperidone | Ivosidenib | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1664,
25,
982
]
],
[
[
1664,
23,
112
],
[
112,
23,
982
]
],
[
[
1664,
24,
543
],
[
543,
24,
982
]
],
[
[
1664,
24,
159
],
[
159,
... | [
[
[
"Risperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Risperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lo... |
DB00424 | DB01085 | 19 | 562 | [
"DDInter896",
"DDInter1465"
] | Hyoscyamine | Pilocarpine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Moderate | 1 | [
[
[
19,
24,
562
]
],
[
[
19,
6,
7992
],
[
7992,
45,
562
]
],
[
[
19,
18,
4930
],
[
4930,
57,
562
]
],
[
[
19,
21,
28669
],
[
28669,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pilocarpine"
]
],
[
[
"Hyoscyamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)"... | Hyoscyamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Pilocarpine (Compound)
Hyoscyamine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Pilocarpine (Compound)
Hyoscyamine (Compound) causes Conjunctivitis (Side Effect) and Conjunctivitis (Side Effect) is caused by Pilocarpine (Co... |
DB01072 | DB06772 | 915 | 310 | [
"DDInter129",
"DDInter259"
] | Atazanavir | Cabazitaxel | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
915,
24,
310
]
],
[
[
915,
25,
973
],
[
973,
24,
310
]
],
[
[
915,
6,
4973
],
[
4973,
45,
310
]
],
[
[
915,
21,
28692
],
[
28692,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
],
[
"Paclitaxe... | Atazanavir may lead to a major life threatening interaction when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Atazanavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cabazitaxel (Compound)
Atazanavir (Compound) causes Ment... |
DB01177 | DB09472 | 77 | 1,383 | [
"DDInter904",
"DDInter1693"
] | Idarubicin | Sodium sulfate | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
77,
24,
1383
]
],
[
[
77,
24,
609
],
[
609,
24,
1383
]
],
[
[
77,
63,
521
],
[
521,
24,
1383
]
],
[
[
77,
24,
1612
],
[
1612,
63... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin... |
DB00196 | DB01001 | 600 | 688 | [
"DDInter743",
"DDInter1632"
] | Fluconazole | Salbutamol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
600,
24,
688
]
],
[
[
600,
24,
455
],
[
455,
24,
688
]
],
[
[
600,
24,
1148
],
[
1148,
63,
688
]
],
[
[
600,
6,
8374
],
[
8374,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Is... |
DB00226 | DB09564 | 1,000 | 1,296 | [
"DDInter845",
"DDInter930"
] | Guanadrel | Insulin degludec | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1000,
24,
1296
]
],
[
[
1000,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1000,
63,
73
],
[
73,
24,
1296
]
],
[
[
1000,
24,
1019
],
[
1019,
... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and... |
DB00496 | DB09065 | 194 | 760 | [
"DDInter480",
"DDInter424"
] | Darifenacin | Cobicistat | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
194,
25,
760
]
],
[
[
194,
63,
1101
],
[
1101,
23,
760
]
],
[
[
194,
24,
1374
],
[
1374,
23,
760
]
],
[
[
194,
24,
723
],
[
723,
... | [
[
[
"Darifenacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abira... |
DB08826 | DB09312 | 1,292 | 967 | [
"DDInter489",
"DDInter103"
] | Deferiprone | Antilymphocyte immunoglobulin (horse) | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Major | 2 | [
[
[
1292,
25,
967
]
],
[
[
1292,
24,
1193
],
[
1193,
62,
967
]
],
[
[
1292,
64,
66
],
[
66,
24,
967
]
],
[
[
1292,
64,
1064
],
[
1064,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antilymphocyte immunoglobulin (horse)"
]
],
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconat... | Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Antilymphocyte immunoglobulin (horse)
Deferiprone may lead to a major life threatening interaction when taken with E... |
DB00346 | DB12141 | 472 | 971 | [
"DDInter44",
"DDInter817"
] | Alfuzosin | Gilteritinib | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
472,
24,
971
]
],
[
[
472,
23,
112
],
[
112,
23,
971
]
],
[
[
472,
24,
485
],
[
485,
24,
971
]
],
[
[
472,
24,
823
],
[
823,
63,... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Alfuzosin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pen... |
DB08865 | DB11932 | 1,593 | 327 | [
"DDInter448",
"DDInter3"
] | Crizotinib | Abametapir (topical) | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1593,
24,
327
]
],
[
[
1593,
25,
124
],
[
124,
63,
327
]
],
[
[
1593,
23,
283
],
[
283,
63,
327
]
],
[
[
1593,
63,
613
],
[
613,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
],
[
"Glasdegib",... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Crizotinib may lead to a major life threatening interaction when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Crizotinib may cause a mino... |
DB00313 | DB00445 | 556 | 322 | [
"DDInter1913",
"DDInter655"
] | Valproic acid | Epirubicin | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
556,
24,
322
]
],
[
[
556,
6,
18701
],
[
18701,
45,
322
]
],
[
[
556,
6,
17332
],
[
17332,
46,
322
]
],
[
[
556,
21,
28970
],
[
28970,... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"UGT2B7"
],
[
"UGT2B7",
"{u} (Gene) is bound by {v} (Compo... | Valproic acid (Compound) binds UGT2B7 (Gene) and UGT2B7 (Gene) is bound by Epirubicin (Compound)
Valproic acid (Compound) binds ALDH5A1 (Gene) and ALDH5A1 (Gene) is upregulated by Epirubicin (Compound)
Valproic acid (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Epirubicin (Compound)
Val... |
DB00624 | DB04868 | 1,561 | 478 | [
"DDInter1775",
"DDInter1293"
] | Testosterone | Nilotinib | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1561,
24,
478
]
],
[
[
1561,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1561,
7,
2703
],
[
2703,
46,
478
]
],
[
[
1561,
18,
8554
],
[
8554,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Testosterone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Testosterone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Testosterone (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Nilotinib (Compound)
Testosterone (Compound) downregulates ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Nilotinib (Compound)
Testosteron... |
DB04865 | DB09075 | 4 | 498 | [
"DDInter1335",
"DDInter621"
] | Omacetaxine mepesuccinate | Edoxaban | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
4,
25,
498
]
],
[
[
4,
24,
1476
],
[
1476,
63,
498
]
],
[
[
4,
24,
637
],
[
637,
24,
498
]
],
[
[
4,
63,
305
],
[
305,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when take... |
DB00414 | DB00624 | 590 | 1,561 | [
"DDInter16",
"DDInter1775"
] | Acetohexamide | Testosterone | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
590,
24,
1561
]
],
[
[
590,
24,
155
],
[
155,
1,
1561
]
],
[
[
590,
24,
870
],
[
870,
63,
1561
]
],
[
[
590,
63,
566
],
[
566,
1... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Testosterone (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a mod... |
DB00813 | DB00877 | 704 | 629 | [
"DDInter722",
"DDInter1678"
] | Fentanyl | Sirolimus | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
704,
24,
629
]
],
[
[
704,
6,
4973
],
[
4973,
45,
629
]
],
[
[
704,
21,
29203
],
[
29203,
60,
629
]
],
[
[
704,
24,
1476
],
[
1476,
... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Fentanyl",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Fentanyl (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Fentanyl (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Sirolimus (Compound)
Fentanyl may cause a moderate interaction that could exacerbate ... |
DB00377 | DB01118 | 1,494 | 33 | [
"DDInter1382",
"DDInter76"
] | Palonosetron | Amiodarone | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Major | 2 | [
[
[
1494,
25,
33
]
],
[
[
1494,
25,
540
],
[
540,
1,
33
]
],
[
[
1494,
6,
7950
],
[
7950,
45,
33
]
],
[
[
1494,
21,
28779
],
[
28779,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
... | Palonosetron may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Palonosetron (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Palonosetron (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side ... |
DB00776 | DB01132 | 1,335 | 1,130 | [
"DDInter1360",
"DDInter1472"
] | Oxcarbazepine | Pioglitazone | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
1335,
24,
1130
]
],
[
[
1335,
6,
8374
],
[
8374,
45,
1130
]
],
[
[
1335,
21,
28778
],
[
28778,
60,
1130
]
],
[
[
1335,
63,
303
],
[
30... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Oxcarbazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pioglitazone (Compound)
Oxcarbazepine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound)
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when... |
DB00939 | DB09268 | 1,338 | 1,662 | [
"DDInter1135",
"DDInter1464"
] | Meclofenamic acid | Picosulfuric acid | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1338,
24,
1662
]
],
[
[
1338,
23,
16
],
[
16,
23,
1662
]
],
[
[
1338,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1338,
63,
91
],
[
91,
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclot... | Meclofenamic acid may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Meclofenamic acid may lead to a major life threatening interaction when taken with Cabozantinib and ... |
DB00692 | DB09128 | 274 | 1,241 | [
"DDInter1448",
"DDInter231"
] | Phentolamine | Brexpiprazole | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
274,
24,
1241
]
],
[
[
274,
24,
549
],
[
549,
24,
1241
]
],
[
[
274,
23,
1296
],
[
1296,
63,
1241
]
],
[
[
274,
62,
1179
],
[
1179,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin de... |
DB08860 | DB13874 | 788 | 1,501 | [
"DDInter1479",
"DDInter639"
] | Pitavastatin | Enasidenib | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
788,
24,
1501
]
],
[
[
788,
63,
663
],
[
663,
24,
1501
]
],
[
[
788,
25,
1510
],
[
1510,
24,
1501
]
],
[
[
788,
1,
700
],
[
700,
... | [
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
... | Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Pitavastatin may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunom... |
DB01181 | DB10343 | 1,532 | 962 | [
"DDInter906",
"DDInter160"
] | Ifosfamide | Bacillus calmette-guerin substrain tice live antigen | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
1532,
25,
962
]
],
[
[
1532,
64,
1057
],
[
1057,
25,
962
]
],
[
[
1532,
24,
270
],
[
270,
64,
962
]
],
[
[
1532,
63,
663
],
[
663,
... | [
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Ifosfamide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizum... |
DB00804 | DB00843 | 1,507 | 479 | [
"DDInter543",
"DDInter583"
] | Dicyclomine | Donepezil | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
1507,
24,
479
]
],
[
[
1507,
21,
28665
],
[
28665,
60,
479
]
],
[
[
1507,
63,
1442
],
[
1442,
24,
479
]
],
[
[
1507,
24,
104
],
[
104,... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Dicyclomine",
"{u} (Compound) causes {v} (Side Effect)",
"Sensory loss"
],
[
"Sensory loss",
"{u} (Side Effect) ... | Dicyclomine (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Donepezil (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Scopolamine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00912 | DB15444 | 473 | 683 | [
"DDInter1581",
"DDInter628"
] | Repaglinide | Elexacaftor | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It received FDA approval in October 2019 in combination with [tezacaftor] and [ivacaftor] as the combination product Trikafta<sup>TM</sup>. Elexacaftor is considered ... | Moderate | 1 | [
[
[
473,
24,
683
]
],
[
[
473,
24,
1450
],
[
1450,
24,
683
]
],
[
[
473,
24,
463
],
[
463,
1,
1088
],
[
1088,
24,
683
]
],
[
[
473,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elexacaftor"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Elexacaftor
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin a... |
DB01165 | DB01575 | 1,539 | 1,054 | [
"DDInter1325",
"DDInter1005"
] | Ofloxacin | Kaolin | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1539,
24,
1054
]
],
[
[
1539,
1,
945
],
[
945,
24,
1054
]
],
[
[
1539,
40,
1176
],
[
1176,
24,
1054
]
],
[
[
1539,
25,
1487
],
[
1487,... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Ofloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Sparfloxacin"
],
[
"Sparfloxacin",
"{u} may cause a moderate ... | Ofloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Ofloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Of... |
DB00570 | DB11732 | 147 | 1,097 | [
"DDInter1936",
"DDInter1027"
] | Vinblastine | Lasmiditan | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
147,
24,
1097
]
],
[
[
147,
24,
971
],
[
971,
63,
1097
]
],
[
[
147,
24,
77
],
[
77,
24,
1097
]
],
[
[
147,
25,
384
],
[
384,
24... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and ... |
DB00241 | DB12267 | 288 | 1,476 | [
"DDInter257",
"DDInter233"
] | Butalbital | Brigatinib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
288,
24,
1476
]
],
[
[
288,
24,
1135
],
[
1135,
23,
1476
]
],
[
[
288,
62,
168
],
[
168,
23,
1476
]
],
[
[
288,
24,
629
],
[
629,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Butalbital may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib m... |
DB00280 | DB14568 | 494 | 982 | [
"DDInter575",
"DDInter1000"
] | Disopyramide | Ivosidenib | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
494,
25,
982
]
],
[
[
494,
23,
112
],
[
112,
23,
982
]
],
[
[
494,
24,
1101
],
[
1101,
23,
982
]
],
[
[
494,
24,
976
],
[
976,
2... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Disopyramide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and ... |
DB01583 | DB06203 | 624 | 1,002 | [
"DDInter1075",
"DDInter51"
] | Liotrix | Alogliptin | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
624,
24,
1002
]
],
[
[
624,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
624,
21,
29814
],
[
29814,
60,
1002
]
],
[
[
624,
63,
176
],
[
176,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
"... | Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Liotrix (Compound) causes Serum sickness (Side Effect) and Serum sickness (Side Effect) is caused by Alogliptin (Compound)
Liotrix may cause a moderate interacti... |
DB08912 | DB12267 | 1,040 | 1,476 | [
"DDInter462",
"DDInter233"
] | Dabrafenib | Brigatinib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
1040,
25,
1476
]
],
[
[
1040,
23,
1612
],
[
1612,
23,
1476
]
],
[
[
1040,
63,
1206
],
[
1206,
23,
1476
]
],
[
[
1040,
24,
1135
],
[
11... | [
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Dabrafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fostemsavir"
],
[
"Fostemsavir... | Dabrafenib may cause a minor interaction that can limit clinical effects when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil and Gemfibr... |
DB00930 | DB01070 | 166 | 1,098 | [
"DDInter432",
"DDInter558"
] | Colesevelam | Dihydrotachysterol | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
166,
24,
1098
]
],
[
[
166,
63,
386
],
[
386,
25,
1098
]
],
[
[
166,
24,
1196
],
[
1196,
64,
1098
]
],
[
[
166,
63,
1331
],
[
1331,
... | [
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Doxercalciferol ... |
DB01041 | DB01166 | 770 | 477 | [
"DDInter1789",
"DDInter379"
] | Thalidomide | Cilostazol | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
770,
24,
477
]
],
[
[
770,
6,
10215
],
[
10215,
45,
477
]
],
[
[
770,
18,
9384
],
[
9384,
57,
477
]
],
[
[
770,
21,
28919
],
[
28919,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Thalidomide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Cilostazol (Compound)
Thalidomide (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Cilostazol (Compound)
Thalidomide (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compoun... |
DB00903 | DB09112 | 1,680 | 1,455 | [
"DDInter686",
"DDInter1306"
] | Etacrynic acid | Nitrous acid | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1680,
24,
1455
]
],
[
[
1680,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
1680,
24,
433
],
[
433,
63,
1455
]
],
[
[
1680,
63,
1061
],
[
1061... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Ertug... |
DB06779 | DB09030 | 365 | 840 | [
"DDInter470",
"DDInter1945"
] | Dalteparin | Vorapaxar | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
365,
25,
840
]
],
[
[
365,
23,
944
],
[
944,
62,
840
]
],
[
[
365,
63,
765
],
[
765,
24,
840
]
],
[
[
365,
64,
885
],
[
885,
24,... | [
[
[
"Dalteparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Dalteparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Dalteparin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a ... |
DB00911 | DB09098 | 458 | 98 | [
"DDInter1811",
"DDInter1700"
] | Tinidazole | Somatrem | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
458,
24,
98
]
],
[
[
458,
63,
168
],
[
168,
23,
98
]
],
[
[
458,
24,
671
],
[
671,
24,
98
]
],
[
[
458,
24,
159
],
[
159,
63,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastat... |
DB00619 | DB01101 | 1,419 | 60 | [
"DDInter909",
"DDInter285"
] | Imatinib | Capecitabine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
1419,
24,
60
]
],
[
[
1419,
6,
6017
],
[
6017,
45,
60
]
],
[
[
1419,
21,
28906
],
[
28906,
60,
60
]
],
[
[
1419,
24,
309
],
[
309,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Capecitabine (Compound)
Imatinib (Compound) causes Gastroenteritis (Side Effect) and Gastroenteritis (Side Effect) is caused by Capecitabine (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilo... |
DB00757 | DB09078 | 1,166 | 1,228 | [
"DDInter581",
"DDInter1036"
] | Dolasetron | Lenvatinib | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1166,
25,
1228
]
],
[
[
1166,
23,
112
],
[
112,
23,
1228
]
],
[
[
1166,
64,
1100
],
[
1100,
24,
1228
]
],
[
[
1166,
25,
938
],
[
938,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Dolasetron may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxine may ca... |
DB00424 | DB01075 | 19 | 1,376 | [
"DDInter896",
"DDInter569"
] | Hyoscyamine | Diphenhydramine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
19,
24,
1376
]
],
[
[
19,
63,
128
],
[
128,
24,
1376
]
],
[
[
19,
24,
832
],
[
832,
24,
1376
]
],
[
[
19,
40,
11228
],
[
11228,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00451 | DB00736 | 542 | 660 | [
"DDInter1064",
"DDInter676"
] | Levothyroxine | Esomeprazole | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Moderate | 1 | [
[
[
542,
24,
660
]
],
[
[
542,
63,
1215
],
[
1215,
40,
660
]
],
[
[
542,
24,
379
],
[
379,
40,
660
]
],
[
[
542,
63,
837
],
[
837,
1... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
]... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Esomeprazole (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Esomepra... |
DB00008 | DB01097 | 491 | 1,377 | [
"DDInter1407",
"DDInter1033"
] | Peginterferon alfa-2a | Leflunomide | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
491,
25,
1377
]
],
[
[
491,
24,
242
],
[
242,
63,
1377
]
],
[
[
491,
25,
1477
],
[
1477,
63,
1377
]
],
[
[
491,
24,
126
],
[
126,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Telbivudine a... |
DB00188 | DB08826 | 168 | 1,292 | [
"DDInter222",
"DDInter489"
] | Bortezomib | Deferiprone | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
168,
25,
1292
]
],
[
[
168,
7,
2215
],
[
2215,
57,
1292
]
],
[
[
168,
21,
28759
],
[
28759,
60,
1292
]
],
[
[
168,
24,
1017
],
[
1017,... | [
[
[
"Bortezomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Bortezomib",
"{u} (Compound) upregulates {v} (Gene)",
"HSPA8"
],
[
"HSPA8",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Bortezomib (Compound) upregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Bortezomib (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Deferiprone (Compound)
Bortezomib may cause a moderate interaction that could exacerb... |
DB01235 | DB08901 | 1,191 | 1,468 | [
"DDInter1054",
"DDInter1492"
] | Levodopa | Ponatinib | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1191,
24,
1468
]
],
[
[
1191,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
1191,
7,
10313
],
[
10313,
46,
1468
]
],
[
[
1191,
18,
4303
],
[
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Levodopa",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Levodopa (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Levodopa (Compound) upregulates CADM1 (Gene) and CADM1 (Gene) is upregulated by Ponatinib (Compound)
Levodopa (Compound) downregulates CLTB (Gene) and CLTB (Gene) is downregulated by Ponatinib (Compound)
Levodopa (Compound) cause... |
DB12159 | DB14711 | 12 | 779 | [
"DDInter609",
"DDInter1680"
] | Dupilumab | Smallpox (Vaccinia) Vaccine, Live | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
12,
25,
779
]
],
[
[
12,
64,
1064
],
[
1064,
25,
779
]
],
[
[
12,
63,
259
],
[
259,
25,
779
]
],
[
[
12,
25,
676
],
[
676,
64,
... | [
[
[
"Dupilumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Dupilumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Clad... | Dupilumab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Dupilumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may ... |
DB00694 | DB08867 | 51 | 807 | [
"DDInter485",
"DDInter1897"
] | Daunorubicin | Ulipristal | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Moderate | 1 | [
[
[
51,
24,
807
]
],
[
[
51,
63,
600
],
[
600,
23,
807
]
],
[
[
51,
24,
609
],
[
609,
23,
807
]
],
[
[
51,
25,
478
],
[
478,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin an... |
DB00906 | DB06691 | 1,567 | 849 | [
"DDInter1801",
"DDInter1155"
] | Tiagabine | Mepyramine | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1567,
24,
849
]
],
[
[
1567,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1567,
24,
272
],
[
272,
24,
849
]
],
[
[
1567,
24,
407
],
[
407,
... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Ch... |
DB00719 | DB09076 | 1,219 | 1,116 | [
"DDInter149",
"DDInter1899"
] | Azatadine | Umeclidinium | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1219,
24,
1116
]
],
[
[
1219,
24,
849
],
[
849,
24,
1116
]
],
[
[
1219,
63,
1300
],
[
1300,
24,
1116
]
],
[
[
1219,
74,
1408
],
[
1408... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Haloperidol and Halop... |
DB04932 | DB11166 | 1,564 | 18 | [
"DDInter491",
"DDInter104"
] | Defibrotide | Antithrombin Alfa | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Major | 2 | [
[
[
1564,
25,
18
]
],
[
[
1564,
63,
1595
],
[
1595,
24,
18
]
],
[
[
1564,
24,
738
],
[
738,
63,
18
]
],
[
[
1564,
24,
1496
],
[
1496,
... | [
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Defibrotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Collagenase clostridium histolyti... | Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum and Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Antithrombin Alfa
Defibrotide may cause a moderate interaction that co... |
DB06603 | DB06779 | 39 | 365 | [
"DDInter1387",
"DDInter470"
] | Panobinostat | Dalteparin | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
39,
25,
365
]
],
[
[
39,
63,
305
],
[
305,
24,
365
]
],
[
[
39,
64,
1100
],
[
1100,
24,
365
]
],
[
[
39,
25,
1427
],
[
1427,
63,... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
],
... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Panobinostat may lead to a major life threatening interaction when taken... |
DB01362 | DB13985 | 497 | 546 | [
"DDInter960",
"DDInter1108"
] | Iohexol | Lutetium Lu 177 dotatate | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Major | 2 | [
[
[
497,
25,
546
]
],
[
[
497,
64,
50
],
[
50,
24,
546
]
],
[
[
497,
25,
1613
],
[
1613,
24,
546
]
],
[
[
497,
64,
629
],
[
629,
25,... | [
[
[
"Iohexol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Iohexol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfasalazine"
],
[
"Sulfasalazine"... | Iohexol may lead to a major life threatening interaction when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Iohexol may lead to a major life threatening interaction when taken with Peginterferon beta-1a and Peginterfer... |
DB00312 | DB04845 | 1,023 | 309 | [
"DDInter1423",
"DDInter1001"
] | Pentobarbital | Ixabepilone | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1023,
24,
309
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
309
]
],
[
[
1023,
21,
28882
],
[
28882,
60,
309
]
],
[
[
1023,
24,
1419
],
[
1419... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Pentobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Pentobarbital (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Ixabepilone (Compound)
Pentobarbital may cause a moderate interaction that could exacerbate... |
DB00196 | DB01255 | 600 | 633 | [
"DDInter743",
"DDInter1078"
] | Fluconazole | Lisdexamfetamine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
600,
24,
633
]
],
[
[
600,
21,
28751
],
[
28751,
60,
633
]
],
[
[
600,
23,
112
],
[
112,
23,
633
]
],
[
[
600,
24,
1494
],
[
1494,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Fluconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effec... | Fluconazole (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Lisdexamfetamine (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken ... |
DB00531 | DB12674 | 450 | 975 | [
"DDInter456",
"DDInter1105"
] | Cyclophosphamide | Lurbinectedin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
450,
24,
975
]
],
[
[
450,
24,
372
],
[
372,
24,
975
]
],
[
[
450,
35,
1532
],
[
1532,
24,
975
]
],
[
[
450,
63,
589
],
[
589,
2... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Cyclophosphamide (Compound) resembles Ifosfamide (Compound) and Cyclophosphamide may cause a moderate... |
DB00486 | DB09061 | 1,614 | 1,627 | [
"DDInter1253",
"DDInter284"
] | Nabilone | Cannabidiol | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1614,
24,
1627
]
],
[
[
1614,
63,
1594
],
[
1594,
24,
1627
]
],
[
[
1614,
24,
662
],
[
662,
24,
1627
]
],
[
[
1614,
24,
407
],
[
407,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbin... |
DB00372 | DB00761 | 999 | 1,621 | [
"DDInter1793",
"DDInter1497"
] | Thiethylperazine | Potassium chloride | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
999,
25,
1621
]
],
[
[
999,
24,
1254
],
[
1254,
62,
1621
]
],
[
[
999,
63,
176
],
[
176,
23,
1621
]
],
[
[
999,
24,
1105
],
[
1105,
... | [
[
[
"Thiethylperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a minor interaction that can limit clinical effects when taken with Potassium chloride
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when ... |
DB05239 | DB08899 | 866 | 129 | [
"DDInter425",
"DDInter649"
] | Cobimetinib | Enzalutamide | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
866,
25,
129
]
],
[
[
866,
63,
918
],
[
918,
1,
129
]
],
[
[
866,
25,
1510
],
[
1510,
24,
129
]
],
[
[
866,
64,
851
],
[
851,
24... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"Bica... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Cobimetinib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could ... |
DB00757 | DB01177 | 1,166 | 77 | [
"DDInter581",
"DDInter904"
] | Dolasetron | Idarubicin | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
1166,
25,
77
]
],
[
[
1166,
6,
6017
],
[
6017,
45,
77
]
],
[
[
1166,
7,
6952
],
[
6952,
46,
77
]
],
[
[
1166,
21,
28987
],
[
28987,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Idarubi... | Dolasetron (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Dolasetron (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound)
Dolasetron (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Dolasetron... |
DB08896 | DB11095 | 292 | 235 | [
"DDInter1576",
"DDInter505"
] | Regorafenib | Desirudin | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
292,
25,
235
]
],
[
[
292,
63,
1100
],
[
1100,
24,
235
]
],
[
[
292,
64,
578
],
[
578,
24,
235
]
],
[
[
292,
24,
41
],
[
41,
24,... | [
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
"Venlafax... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Regorafenib may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cau... |
DB00526 | DB00581 | 1,555 | 355 | [
"DDInter1355",
"DDInter1018"
] | Oxaliplatin | Lactulose | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
1555,
24,
355
]
],
[
[
1555,
24,
416
],
[
416,
40,
355
]
],
[
[
1555,
24,
361
],
[
361,
62,
355
]
],
[
[
1555,
24,
1262
],
[
1262,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
],
[
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin (Compound) resembles Lactulose (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a minor interaction that can limit cli... |
DB00783 | DB08912 | 1,438 | 1,040 | [
"DDInter679",
"DDInter462"
] | Estradiol | Dabrafenib | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1438,
24,
1040
]
],
[
[
1438,
6,
13478
],
[
13478,
45,
1040
]
],
[
[
1438,
18,
2814
],
[
2814,
46,
1040
]
],
[
[
1438,
7,
6358
],
[
63... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Estradiol",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B3"
],
[
"SLCO1B3",
"{u} (Gene) is bound by {v} (Compound)",... | Estradiol (Compound) binds SLCO1B3 (Gene) and SLCO1B3 (Gene) is bound by Dabrafenib (Compound)
Estradiol (Compound) downregulates NFATC4 (Gene) and NFATC4 (Gene) is upregulated by Dabrafenib (Compound)
Estradiol (Compound) upregulates RAB4A (Gene) and RAB4A (Gene) is upregulated by Dabrafenib (Compound)
Estradiol (Comp... |
DB11978 | DB12332 | 124 | 1,619 | [
"DDInter822",
"DDInter1626"
] | Glasdegib | Rucaparib | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
124,
24,
1619
]
],
[
[
124,
64,
307
],
[
307,
23,
1619
]
],
[
[
124,
63,
271
],
[
271,
23,
1619
]
],
[
[
124,
62,
112
],
[
112,
... | [
[
[
"Glasdegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Glasdegib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Glasdegib may lead to a major life threatening interaction when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron may cause a minor... |
DB00047 | DB00451 | 176 | 542 | [
"DDInter932",
"DDInter1064"
] | Insulin glargine | Levothyroxine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
176,
24,
542
]
],
[
[
176,
24,
624
],
[
624,
1,
542
]
],
[
[
176,
24,
88
],
[
88,
23,
542
]
],
[
[
176,
24,
729
],
[
729,
62,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Levothyroxine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol may cause a minor interaction that... |
DB00220 | DB00491 | 798 | 127 | [
"DDInter1276",
"DDInter1217"
] | Nelfinavir | Miglitol | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
798,
24,
127
]
],
[
[
798,
21,
29180
],
[
29180,
60,
127
]
],
[
[
798,
23,
1194
],
[
1194,
62,
127
]
],
[
[
798,
25,
1486
],
[
1486,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Nelfinavir",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal distension"
],
[
"Abdominal distension",
"{u} (... | Nelfinavir (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Miglitol (Compound)
Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when ta... |
DB00421 | DB00759 | 443 | 1,620 | [
"DDInter1707",
"DDInter1783"
] | Spironolactone | Tetracycline | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Minor | 0 | [
[
[
443,
23,
1620
]
],
[
[
443,
23,
1572
],
[
1572,
40,
1620
]
],
[
[
443,
62,
964
],
[
964,
40,
1620
]
],
[
[
443,
23,
126
],
[
126,
... | [
[
[
"Spironolactone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracycline"
]
],
[
[
"Spironolactone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demeclocycline"
]... | Spironolactone may cause a minor interaction that can limit clinical effects when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Doxycycline and Doxycycline (Compound) resembles Tetrac... |
DB00404 | DB01377 | 523 | 1,283 | [
"DDInter54",
"DDInter1119"
] | Alprazolam | Magnesium oxide | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
523,
23,
1283
]
],
[
[
523,
23,
1573
],
[
1573,
23,
1283
]
],
[
[
523,
1,
905
],
[
905,
23,
1283
]
],
[
[
523,
40,
1174
],
[
1174,
... | [
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
... | Alprazolam may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Alprazolam (Compound) resembles Lorazepam (Compound) and Lorazepam may cause a minor interaction that can limit... |
DB00945 | DB04896 | 1,479 | 901 | [
"DDInter20",
"DDInter1220"
] | Acetylsalicylic acid | Milnacipran | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1479,
24,
901
]
],
[
[
1479,
24,
41
],
[
41,
1,
901
]
],
[
[
1479,
21,
28722
],
[
28722,
60,
901
]
],
[
[
1479,
25,
405
],
[
405,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomi... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Acetylsalicylic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Milnacipran (Compound)
Acetylsalicylic ac... |
DB01068 | DB01390 | 1,565 | 1,117 | [
"DDInter411",
"DDInter1683"
] | Clonazepam | Sodium bicarbonate | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
1565,
23,
1117
]
],
[
[
1565,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
1565,
40,
1382
],
[
1382,
23,
1117
]
],
[
[
1565,
1,
905
],
[
90... | [
[
[
"Clonazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Clonazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is ca... | Clonazepam (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Clonazepam (Compound) resembles Midazolam (Compound) and Midazolam may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Clonazepam (Compound) resembles Lora... |
DB01098 | DB04845 | 14 | 309 | [
"DDInter1622",
"DDInter1001"
] | Rosuvastatin | Ixabepilone | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
14,
24,
309
]
],
[
[
14,
6,
8374
],
[
8374,
45,
309
]
],
[
[
14,
21,
28681
],
[
28681,
60,
309
]
],
[
[
14,
63,
139
],
[
139,
24... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Rosuvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Rosuvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Rosuvastatin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Ixabepilone (Compound)
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00222 | DB00524 | 245 | 811 | [
"DDInter825",
"DDInter1199"
] | Glimepiride | Metolazone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Moderate | 1 | [
[
[
245,
24,
811
]
],
[
[
245,
24,
1605
],
[
1605,
40,
811
]
],
[
[
245,
24,
1014
],
[
1014,
1,
811
]
],
[
[
245,
21,
28963
],
[
28963,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Metolazone (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Metolazone (Comp... |
DB00999 | DB01249 | 504 | 258 | [
"DDInter883",
"DDInter958"
] | Hydrochlorothiazide | Iodixanol | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
504,
24,
258
]
],
[
[
504,
24,
497
],
[
497,
1,
258
]
],
[
[
504,
21,
28748
],
[
28748,
60,
258
]
],
[
[
504,
40,
178
],
[
178,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Hydrochlorothiazide (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Hydrochlorothiazide (Compound) resembl... |
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