drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB08820 | DB11718 | 1,478 | 927 | [
"DDInter997",
"DDInter640"
] | Ivacaftor | Encorafenib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1478,
24,
927
]
],
[
[
1478,
63,
1247
],
[
1247,
23,
927
]
],
[
[
1478,
63,
372
],
[
372,
24,
927
]
],
[
[
1478,
24,
484
],
[
484,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine ... |
DB00196 | DB00563 | 600 | 663 | [
"DDInter743",
"DDInter1174"
] | Fluconazole | Methotrexate | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
600,
24,
663
]
],
[
[
600,
6,
4973
],
[
4973,
45,
663
]
],
[
[
600,
18,
7847
],
[
7847,
57,
663
]
],
[
[
600,
21,
28681
],
[
28681,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Fluconazole (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Methotrexate (Compound)
Fluconazole (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotr... |
DB00280 | DB09472 | 494 | 1,383 | [
"DDInter575",
"DDInter1693"
] | Disopyramide | Sodium sulfate | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Major | 2 | [
[
[
494,
25,
1383
]
],
[
[
494,
25,
609
],
[
609,
24,
1383
]
],
[
[
494,
24,
1311
],
[
1311,
24,
1383
]
],
[
[
494,
64,
521
],
[
521,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromyci... | Disopyramide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and M... |
DB00789 | DB09340 | 1,431 | 1,013 | [
"DDInter796",
"DDInter1895"
] | Gadopentetic acid | Tyropanoic acid | A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
1431,
24,
1013
]
],
[
[
1431,
24,
1586
],
[
1586,
24,
1013
]
],
[
[
1431,
63,
1081
],
[
1081,
24,
1013
]
],
[
[
1431,
1,
808
],
[
808,... | [
[
[
"Gadopentetic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Gadopentetic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlod... | Gadopentetic acid may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine and Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Gadopentetic acid may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00322 | DB08904 | 141 | 375 | [
"DDInter742",
"DDInter342"
] | Floxuridine | Certolizumab pegol | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
141,
25,
375
]
],
[
[
141,
63,
1461
],
[
1461,
23,
375
]
],
[
[
141,
1,
231
],
[
231,
24,
375
]
],
[
[
141,
24,
200
],
[
200,
63... | [
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"V... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Floxuridine (Compound) resembles Stavudine (Compound) and Stavudine may cause a moderate interaction that c... |
DB00188 | DB00313 | 168 | 556 | [
"DDInter222",
"DDInter1913"
] | Bortezomib | Valproic acid | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Minor | 0 | [
[
[
168,
23,
556
]
],
[
[
168,
6,
8374
],
[
8374,
45,
556
]
],
[
[
168,
21,
28889
],
[
28889,
60,
556
]
],
[
[
168,
23,
660
],
[
660,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Valproic acid"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Bortezomib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Valproic acid (Compound)
Bortezomib (Compound) causes Cyst (Side Effect) and Cyst (Side Effect) is caused by Valproic acid (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomepra... |
DB00862 | DB01211 | 1,005 | 609 | [
"DDInter1918",
"DDInter393"
] | Vardenafil | Clarithromycin | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
1005,
25,
609
]
],
[
[
1005,
6,
7524
],
[
7524,
45,
609
]
],
[
[
1005,
7,
8155
],
[
8155,
46,
609
]
],
[
[
1005,
21,
28759
],
[
28759,... | [
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Cla... | Vardenafil (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Vardenafil (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Clarithromycin (Compound)
Vardenafil (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect)... |
DB00902 | DB08907 | 104 | 1,344 | [
"DDInter1168",
"DDInter280"
] | Methdilazine | Canagliflozin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
104,
24,
1344
]
],
[
[
104,
24,
549
],
[
549,
1,
1344
]
],
[
[
104,
63,
1523
],
[
1523,
24,
1344
]
],
[
[
104,
24,
697
],
[
697,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may cause a moderate interaction... |
DB00960 | DB11130 | 887 | 407 | [
"DDInter1471",
"DDInter1344"
] | Pindolol | Opium | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
887,
24,
407
]
],
[
[
887,
23,
1054
],
[
1054,
24,
407
]
],
[
[
887,
24,
976
],
[
976,
24,
407
]
],
[
[
887,
63,
104
],
[
104,
2... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Pindolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Kaolin"
],
[
"Kaolin",
... | Pindolol may cause a minor interaction that can limit clinical effects when taken with Kaolin and Kaolin may cause a moderate interaction that could exacerbate diseases when taken with Opium
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a ... |
DB00099 | DB00445 | 440 | 322 | [
"DDInter735",
"DDInter655"
] | Filgrastim | Epirubicin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
440,
24,
322
]
],
[
[
440,
24,
1307
],
[
1307,
62,
322
]
],
[
[
440,
63,
1648
],
[
1648,
24,
322
]
],
[
[
440,
24,
1224
],
[
1224,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleuk... |
DB00242 | DB00620 | 1,064 | 175 | [
"DDInter392",
"DDInter1855"
] | Cladribine | Triamcinolone | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Major | 2 | [
[
[
1064,
25,
175
]
],
[
[
1064,
25,
1573
],
[
1573,
1,
175
]
],
[
[
1064,
25,
617
],
[
617,
40,
175
]
],
[
[
1064,
64,
1351
],
[
1351,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
],
[
"Prednisone",
"{u... | Cladribine may lead to a major life threatening interaction when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Cladribine may lead to a major life threatening interaction when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compound)
Cladribine may lead to a... |
DB04868 | DB06674 | 478 | 908 | [
"DDInter1293",
"DDInter837"
] | Nilotinib | Golimumab | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
478,
25,
908
]
],
[
[
478,
63,
336
],
[
336,
24,
908
]
],
[
[
478,
64,
697
],
[
697,
24,
908
]
],
[
[
478,
24,
517
],
[
517,
63,... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
[
"Nifedipine",
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Nilotinib may lead to a major life threatening interaction when taken with Phenobarbital and Phenobarbital may cau... |
DB00938 | DB01105 | 455 | 222 | [
"DDInter1635",
"DDInter1665"
] | Salmeterol | Sibutramine | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
455,
24,
222
]
],
[
[
455,
6,
8374
],
[
8374,
45,
222
]
],
[
[
455,
21,
28698
],
[
28698,
60,
222
]
],
[
[
455,
63,
839
],
[
839,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Salmeterol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Salmeterol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and G... |
DB00470 | DB01100 | 530 | 1,568 | [
"DDInter601",
"DDInter1470"
] | Dronabinol | Pimozide | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
530,
24,
1568
]
],
[
[
530,
63,
78
],
[
78,
40,
1568
]
],
[
[
530,
6,
4973
],
[
4973,
45,
1568
]
],
[
[
530,
21,
28766
],
[
28766,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Dronabinol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pimozide (Compound)
Dronabinol (Compound) causes Hypotension (Side Effect) and Hypotension (... |
DB00804 | DB01176 | 1,507 | 537 | [
"DDInter543",
"DDInter453"
] | Dicyclomine | Cyclizine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1507,
24,
537
]
],
[
[
1507,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1507,
24,
104
],
[
104,
1,
537
]
],
[
[
1507,
63,
13
],
[
13,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and M... |
DB00554 | DB06209 | 1,027 | 256 | [
"DDInter1478",
"DDInter1508"
] | Piroxicam | Prasugrel | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
1027,
25,
256
]
],
[
[
1027,
6,
1829
],
[
1829,
45,
256
]
],
[
[
1027,
62,
752
],
[
752,
23,
256
]
],
[
[
1027,
23,
1127
],
[
1127,
... | [
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
"Prasugrel"
]... | Piroxicam (Compound) binds ALB (Gene) and ALB (Gene) is bound by Prasugrel (Compound)
Piroxicam may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Piroxicam may cause a minor inte... |
DB06335 | DB08827 | 761 | 990 | [
"DDInter1646",
"DDInter1085"
] | Saxagliptin | Lomitapide | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
761,
24,
990
]
],
[
[
761,
63,
1080
],
[
1080,
1,
990
]
],
[
[
761,
6,
8374
],
[
8374,
45,
990
]
],
[
[
761,
21,
28658
],
[
28658,
... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Saxagliptin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Saxagliptin (Compound) causes Vomiting (Side Effect) and Vomitin... |
DB05015 | DB15091 | 1,077 | 676 | [
"DDInter174",
"DDInter1901"
] | Belinostat | Upadacitinib | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1077,
25,
676
]
],
[
[
1077,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1077,
63,
248
],
[
248,
24,
676
]
],
[
[
1077,
63,
1184
],
[
1184,
... | [
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir ... |
DB04868 | DB15035 | 478 | 503 | [
"DDInter1293",
"DDInter1959"
] | Nilotinib | Zanubrutinib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Moderate | 1 | [
[
[
478,
24,
503
]
],
[
[
478,
24,
1094
],
[
1094,
24,
503
]
],
[
[
478,
25,
982
],
[
982,
24,
503
]
],
[
[
478,
63,
222
],
[
222,
2... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Nilotinib may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may caus... |
DB01764 | DB15091 | 805 | 676 | [
"DDInter469",
"DDInter1901"
] | Dalfopristin | Upadacitinib | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
805,
24,
676
]
],
[
[
805,
23,
283
],
[
283,
24,
676
]
],
[
[
805,
24,
1593
],
[
1593,
24,
676
]
],
[
[
805,
63,
723
],
[
723,
2... | [
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Dalfopristin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fedratinib"
],
... | Dalfopristin may cause a minor interaction that can limit clinical effects when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Cr... |
DB00224 | DB11718 | 215 | 927 | [
"DDInter917",
"DDInter640"
] | Indinavir | Encorafenib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
215,
25,
927
]
],
[
[
215,
24,
659
],
[
659,
24,
927
]
],
[
[
215,
63,
1324
],
[
1324,
24,
927
]
],
[
[
215,
25,
1491
],
[
1491,
... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
"Vilanterol"... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Trogl... |
DB00176 | DB04932 | 529 | 1,564 | [
"DDInter770",
"DDInter491"
] | Fluvoxamine | Defibrotide | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
529,
24,
1564
]
],
[
[
529,
25,
1039
],
[
1039,
24,
1564
]
],
[
[
529,
24,
714
],
[
714,
24,
1564
]
],
[
[
529,
25,
1347
],
[
1347,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Fluvoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"De... | Fluvoxamine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost m... |
DB00477 | DB06723 | 216 | 115 | [
"DDInter363",
"DDInter58"
] | Chlorpromazine | Aluminum hydroxide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
216,
23,
115
]
],
[
[
216,
21,
28643
],
[
28643,
60,
115
]
],
[
[
216,
24,
870
],
[
870,
23,
115
]
],
[
[
216,
40,
1630
],
[
1630,
... | [
[
[
"Chlorpromazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side E... | Chlorpromazine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects... |
DB00850 | DB01254 | 1,630 | 1,213 | [
"DDInter1432",
"DDInter484"
] | Perphenazine | Dasatinib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1630,
24,
1213
]
],
[
[
1630,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1630,
7,
18110
],
[
18110,
46,
1213
]
],
[
[
1630,
18,
20113
],
[
2... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Perphenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Perphenazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Perphenazine (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Dasatinib (Compound)
Perphenazine (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Dasatinib (Compound)
Per... |
DB00673 | DB13179 | 723 | 68 | [
"DDInter112",
"DDInter1882"
] | Aprepitant | Troleandomycin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
723,
24,
68
]
],
[
[
723,
62,
1101
],
[
1101,
23,
68
]
],
[
[
723,
23,
222
],
[
222,
23,
68
]
],
[
[
723,
24,
309
],
[
309,
24,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Aprepitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Aprepitant may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Aprepitant may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutra... |
DB00215 | DB01064 | 1,230 | 1,148 | [
"DDInter388",
"DDInter987"
] | Citalopram | Isoprenaline | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
1230,
25,
1148
]
],
[
[
1230,
24,
480
],
[
480,
24,
1148
]
],
[
[
1230,
21,
28717
],
[
28717,
60,
1148
]
],
[
[
1230,
25,
1151
],
[
11... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoter... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Citalopram (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Isoprenaline (Comp... |
DB00290 | DB00853 | 329 | 1,686 | [
"DDInter219",
"DDInter1762"
] | Bleomycin | Temozolomide | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
329,
24,
1686
]
],
[
[
329,
5,
11556
],
[
11556,
44,
1686
]
],
[
[
329,
21,
28996
],
[
28996,
60,
1686
]
],
[
[
329,
23,
945
],
[
945,... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Bleomycin",
"{u} (Compound) treats {v} (Disease)",
"melanoma"
],
[
"melanoma",
"{u} (Disease) is treated by {v}... | Bleomycin (Compound) treats melanoma (Disease) and melanoma (Disease) is treated by Temozolomide (Compound)
Bleomycin (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Temozolomide (Compound)
Bleomycin may cause a minor interaction that can limit clinic... |
DB11799 | DB13142 | 627 | 841 | [
"DDInter205",
"DDInter274"
] | Bictegravir | Calcium glubionate anhydrous | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Major | 2 | [
[
[
627,
25,
841
]
],
[
[
627,
63,
72
],
[
72,
24,
841
]
],
[
[
627,
64,
1283
],
[
1283,
24,
255
],
[
255,
24,
841
]
],
[
[
627,
63,... | [
[
[
"Bictegravir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Bictegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
],
... | Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Bictegravir may lead to a major life threatening interaction when taken with Magnesium oxid... |
DB00285 | DB11113 | 1,100 | 657 | [
"DDInter1927",
"DDInter307"
] | Venlafaxine | Castor oil | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1100,
24,
657
]
],
[
[
1100,
24,
927
],
[
927,
63,
657
]
],
[
[
1100,
40,
534
],
[
534,
24,
657
]
],
[
[
1100,
24,
1491
],
[
1491,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Venlafaxine (Compound) resembles Tramadol (Compound) and Tramadol may cause a moderate interaction that could... |
DB00808 | DB09082 | 1,605 | 659 | [
"DDInter916",
"DDInter1934"
] | Indapamide | Vilanterol | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1605,
24,
659
]
],
[
[
1605,
24,
1220
],
[
1220,
23,
659
]
],
[
[
1605,
63,
1573
],
[
1573,
23,
659
]
],
[
[
1605,
24,
1296
],
[
1296,... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Pr... |
DB01168 | DB01176 | 1,053 | 537 | [
"DDInter1526",
"DDInter453"
] | Procarbazine | Cyclizine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1053,
24,
537
]
],
[
[
1053,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1053,
63,
104
],
[
104,
1,
537
]
],
[
[
1053,
63,
601
],
[
601,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and M... |
DB00290 | DB00352 | 329 | 482 | [
"DDInter219",
"DDInter1814"
] | Bleomycin | Tioguanine | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Moderate | 1 | [
[
[
329,
24,
482
]
],
[
[
329,
5,
11555
],
[
11555,
44,
482
]
],
[
[
329,
21,
28868
],
[
28868,
60,
482
]
],
[
[
329,
23,
945
],
[
945,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
]
],
[
[
"Bleomycin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease)... | Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Tioguanine (Compound)
Bleomycin (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Tioguanine (Compound)
Bleomycin may cause a minor interaction that can limit clinical effects when ... |
DB08886 | DB09122 | 637 | 1,613 | [
"DDInter126",
"DDInter1409"
] | Asparaginase Erwinia chrysanthemi | Peginterferon beta-1a | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
637,
24,
1613
]
],
[
[
637,
63,
600
],
[
600,
24,
1613
]
],
[
[
637,
24,
292
],
[
292,
24,
1613
]
],
[
[
637,
24,
1276
],
[
1276,
... | [
[
[
"Asparaginase Erwinia chrysanthemi",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Asparaginase Erwinia chrysanthemi",
"{u} may cause a moderate interaction that could exacerbate diseases... | Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Asparaginase Erwinia chrysanthemi may cause a moderate interaction that coul... |
DB00261 | DB11986 | 702 | 484 | [
"DDInter93",
"DDInter648"
] | Anagrelide | Entrectinib | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
702,
25,
484
]
],
[
[
702,
23,
1247
],
[
1247,
23,
484
]
],
[
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702,
24,
222
],
[
222,
23,
484
]
],
[
[
702,
25,
1539
],
[
1539,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfa... | Anagrelide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine ... |
DB00836 | DB01087 | 543 | 1,520 | [
"DDInter1088",
"DDInter1520"
] | Loperamide | Primaquine | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
543,
24,
1520
]
],
[
[
543,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
543,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
543,
21,
28722
],
[
2872... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Loperamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Loperamide (Compo... |
DB08873 | DB14568 | 74 | 982 | [
"DDInter221",
"DDInter1000"
] | Boceprevir | Ivosidenib | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
74,
25,
982
]
],
[
[
74,
63,
168
],
[
168,
23,
982
]
],
[
[
74,
25,
976
],
[
976,
24,
982
]
],
[
[
74,
64,
543
],
[
543,
24,
... | [
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Boceprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomib... | Boceprevir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Boceprevir may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause ... |
DB08867 | DB12010 | 807 | 214 | [
"DDInter1897",
"DDInter785"
] | Ulipristal | Fostamatinib | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
807,
24,
214
]
],
[
[
807,
62,
723
],
[
723,
24,
214
]
],
[
[
807,
63,
866
],
[
866,
24,
214
]
],
[
[
807,
24,
1421
],
[
1421,
6... | [
[
[
"Ulipristal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Ulipristal",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aprepitant"
],
[
... | Ulipristal may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Ulipristal may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib and Cobim... |
DB05679 | DB06616 | 1,683 | 594 | [
"DDInter1907",
"DDInter224"
] | Ustekinumab | Bosutinib | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1683,
24,
594
]
],
[
[
1683,
24,
713
],
[
713,
63,
594
]
],
[
[
1683,
63,
663
],
[
663,
24,
594
]
],
[
[
1683,
24,
1250
],
[
1250,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
],
... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Methot... |
DB00843 | DB12010 | 479 | 214 | [
"DDInter583",
"DDInter785"
] | Donepezil | Fostamatinib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
479,
24,
214
]
],
[
[
479,
24,
976
],
[
976,
24,
214
]
],
[
[
479,
62,
723
],
[
723,
24,
214
]
],
[
[
479,
63,
51
],
[
51,
24,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Donepezil may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepi... |
DB00270 | DB00358 | 1,428 | 1,010 | [
"DDInter993",
"DDInter1140"
] | Isradipine | Mefloquine | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
1428,
24,
1010
]
],
[
[
1428,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
1428,
21,
28789
],
[
28789,
60,
1010
]
],
[
[
1428,
24,
392
],
[
39... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Isradipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Isradipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Isradipine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Mefloquine (Compound)
Isradipine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB06043 | DB08868 | 1,644 | 1,011 | [
"DDInter1328",
"DDInter737"
] | Olaratumab | Fingolimod | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1644,
25,
1011
]
],
[
[
1644,
24,
748
],
[
748,
63,
1011
]
],
[
[
1644,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
1644,
25,
976
],
[
976,
... | [
[
[
"Olaratumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Olaratumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anthr... | Olaratumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Olaratumab may cause a moderate interaction that could exacerbate diseases when taken with Denosumab a... |
DB00349 | DB01377 | 902 | 1,283 | [
"DDInter401",
"DDInter1119"
] | Clobazam | Magnesium oxide | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
902,
23,
1283
]
],
[
[
902,
40,
216
],
[
216,
23,
1283
]
],
[
[
902,
63,
1018
],
[
1018,
23,
1283
]
],
[
[
902,
24,
104
],
[
104,
... | [
[
[
"Clobazam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Clobazam",
"{u} (Compound) resembles {v} (Compound)",
"Chlorpromazine"
],
[
"Chlorpromazine",
"{u} may cause a ... | Clobazam (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may cause a minor interaction that... |
DB00832 | DB00835 | 499 | 100 | [
"DDInter1446",
"DDInter245"
] | Phensuximide | Brompheniramine | Phensuximide is a member of the succinimide class with anticonvulsant properties. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
499,
24,
100
]
],
[
[
499,
63,
128
],
[
128,
24,
100
]
],
[
[
499,
6,
10215
],
[
10215,
45,
100
]
],
[
[
499,
24,
1311
],
[
1311,
... | [
[
[
"Phensuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Phensuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine... | Phensuximide may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Phensuximide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Bromphenirami... |
DB01240 | DB01367 | 885 | 1,163 | [
"DDInter657",
"DDInter1572"
] | Epoprostenol | Rasagiline | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
885,
24,
1163
]
],
[
[
885,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
885,
63,
1445
],
[
1445,
24,
1163
]
],
[
[
885,
24,
22
],
[
22,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Epoprostenol",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is ca... | Epoprostenol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00056 | DB00446 | 816 | 597 | [
"DDInter814",
"DDInter351"
] | Gemtuzumab ozogamicin | Chloramphenicol | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
816,
24,
597
]
],
[
[
816,
24,
1627
],
[
1627,
62,
597
]
],
[
[
816,
24,
599
],
[
599,
24,
597
]
],
[
[
816,
24,
810
],
[
810,
6... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken... |
DB01075 | DB01221 | 1,376 | 1,190 | [
"DDInter569",
"DDInter1007"
] | Diphenhydramine | Ketamine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
1376,
24,
1190
]
],
[
[
1376,
6,
7603
],
[
7603,
45,
1190
]
],
[
[
1376,
21,
28787
],
[
28787,
60,
1190
]
],
[
[
1376,
24,
649
],
[
64... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2B6"
],
[
"CYP2B6",
"{u} (Gene) is bound by {v} (Com... | Diphenhydramine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ketamine (Compound)
Diphenhydramine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ketamine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofed... |
DB00563 | DB01234 | 663 | 1,220 | [
"DDInter1174",
"DDInter513"
] | Methotrexate | Dexamethasone | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
663,
24,
1220
]
],
[
[
663,
24,
870
],
[
870,
1,
1220
]
],
[
[
663,
24,
175
],
[
175,
40,
1220
]
],
[
[
663,
63,
251
],
[
251,
1... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles... |
DB00261 | DB04946 | 702 | 924 | [
"DDInter93",
"DDInter907"
] | Anagrelide | Iloperidone | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
702,
25,
924
]
],
[
[
702,
25,
1664
],
[
1664,
1,
924
]
],
[
[
702,
25,
1425
],
[
1425,
25,
924
]
],
[
[
702,
25,
519
],
[
519,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risperidone"
],
[
"Risperidone",
"{u... | Anagrelide may lead to a major life threatening interaction when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when taken with Iloperi... |
DB00999 | DB01088 | 504 | 714 | [
"DDInter883",
"DDInter908"
] | Hydrochlorothiazide | Iloprost | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
504,
24,
714
]
],
[
[
504,
63,
1648
],
[
1648,
24,
714
]
],
[
[
504,
1,
1577
],
[
1577,
24,
714
]
],
[
[
504,
24,
1450
],
[
1450,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Hydrochlorothiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may cause... |
DB00238 | DB08870 | 188 | 850 | [
"DDInter1285",
"DDInter228"
] | Nevirapine | Brentuximab vedotin | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
188,
24,
850
]
],
[
[
188,
24,
896
],
[
896,
24,
850
]
],
[
[
188,
24,
1033
],
[
1033,
63,
850
]
],
[
[
188,
63,
305
],
[
305,
2... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and ... |
DB00744 | DB04868 | 1,288 | 478 | [
"DDInter1962",
"DDInter1293"
] | Zileuton | Nilotinib | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1288,
24,
478
]
],
[
[
1288,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1288,
7,
3008
],
[
3008,
46,
478
]
],
[
[
1288,
21,
28762
],
[
28762,... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Zileuton",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Zileuton (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Zileuton (Compound) upregulates GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Nilotinib (Compound)
Zileuton (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nilotinib (Compound)
Zileuton may caus... |
DB00218 | DB08865 | 1,176 | 1,593 | [
"DDInter1247",
"DDInter448"
] | Moxifloxacin | Crizotinib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1176,
25,
1593
]
],
[
[
1176,
6,
3199
],
[
3199,
57,
1593
]
],
[
[
1176,
21,
29093
],
[
29093,
60,
1593
]
],
[
[
1176,
23,
450
],
[
45... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) binds {v} (Gene)",
"TOP2A"
],
[
"TOP2A",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Crizotinib (Compound)
Moxifloxacin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Cyclophospham... |
DB00001 | DB00580 | 1,578 | 311 | [
"DDInter1037",
"DDInter1910"
] | Lepirudin | Valdecoxib | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
1578,
24,
311
]
],
[
[
1578,
25,
366
],
[
366,
24,
311
]
],
[
[
1578,
25,
500
],
[
500,
63,
311
]
],
[
[
1578,
24,
1512
],
[
1512,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],
[
"Eptifibati... | Lepirudin may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Lepirudin may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate in... |
DB00347 | DB01075 | 917 | 1,376 | [
"DDInter1871",
"DDInter569"
] | Trimethadione | Diphenhydramine | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
917,
24,
1376
]
],
[
[
917,
24,
128
],
[
128,
24,
1376
]
],
[
[
917,
6,
10215
],
[
10215,
45,
1376
]
],
[
[
917,
21,
28784
],
[
28784,... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbromphenirami... | Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Trimethadione (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Diphenhydra... |
DB01125 | DB01276 | 279 | 123 | [
"DDInter98",
"DDInter706"
] | Anisindione | Exenatide | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
279,
24,
123
]
],
[
[
279,
24,
708
],
[
708,
63,
123
]
],
[
[
279,
63,
1573
],
[
1573,
24,
123
]
],
[
[
279,
24,
1220
],
[
1220,
... | [
[
[
"Anisindione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Anisindione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
... | Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and... |
DB00681 | DB01267 | 1,287 | 519 | [
"DDInter85",
"DDInter1381"
] | Amphotericin B | Paliperidone | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1287,
24,
519
]
],
[
[
1287,
24,
1664
],
[
1664,
1,
519
]
],
[
[
1287,
21,
29459
],
[
29459,
60,
519
]
],
[
[
1287,
63,
589
],
[
589,
... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Amphotericin B (Compound) causes Skin discolouration (Side Effect) and Skin discolouration (Side Effect) is caused by Paliperidone (Compound)
Amphoteric... |
DB00802 | DB12332 | 1,322 | 1,619 | [
"DDInter43",
"DDInter1626"
] | Alfentanil | Rucaparib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1322,
24,
1619
]
],
[
[
1322,
25,
222
],
[
222,
23,
1619
]
],
[
[
1322,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
1322,
64,
1419
],
[
1419... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Alfentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramin... | Alfentanil may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric ac... |
DB00390 | DB01129 | 1,252 | 379 | [
"DDInter554",
"DDInter1559"
] | Digoxin | Rabeprazole | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
1252,
24,
379
]
],
[
[
1252,
24,
1215
],
[
1215,
40,
379
]
],
[
[
1252,
24,
660
],
[
660,
1,
379
]
],
[
[
1252,
63,
837
],
[
837,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (Compou... |
DB00486 | DB01023 | 1,614 | 409 | [
"DDInter1253",
"DDInter716"
] | Nabilone | Felodipine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
1614,
24,
409
]
],
[
[
1614,
63,
376
],
[
376,
40,
409
]
],
[
[
1614,
24,
1081
],
[
1081,
40,
409
]
],
[
[
1614,
63,
1428
],
[
1428,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Felodipine (Compound)
Na... |
DB04868 | DB10429 | 478 | 200 | [
"DDInter1293",
"DDInter282"
] | Nilotinib | Candida albicans | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
478,
24,
200
]
],
[
[
478,
24,
1683
],
[
1683,
24,
200
]
],
[
[
478,
25,
976
],
[
976,
24,
200
]
],
[
[
478,
63,
168
],
[
168,
2... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Nilotinib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00175 | DB08904 | 681 | 375 | [
"DDInter1509",
"DDInter342"
] | Pravastatin | Certolizumab pegol | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
681,
24,
375
]
],
[
[
681,
24,
1047
],
[
1047,
24,
375
]
],
[
[
681,
24,
1434
],
[
1434,
63,
375
]
],
[
[
681,
63,
491
],
[
491,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtan... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine and Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Pravastatin may cause a moderate interaction that could exacerbate diseases when ... |
DB00206 | DB00959 | 1,245 | 1,486 | [
"DDInter1582",
"DDInter1191"
] | Reserpine | Methylprednisolone | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
1245,
24,
1486
]
],
[
[
1245,
24,
175
],
[
175,
40,
1486
]
],
[
[
1245,
24,
167
],
[
167,
1,
1486
]
],
[
[
1245,
6,
4973
],
[
4973,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Me... |
DB01021 | DB08882 | 674 | 1,281 | [
"DDInter1861",
"DDInter1070"
] | Trichlormethiazide | Linagliptin | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
674,
24,
1281
]
],
[
[
674,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
674,
63,
251
],
[
251,
24,
1281
]
],
[
[
674,
24,
1220
],
[
1220,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate... |
DB00352 | DB00812 | 482 | 998 | [
"DDInter1814",
"DDInter1451"
] | Tioguanine | Phenylbutazone | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
482,
24,
998
]
],
[
[
482,
63,
362
],
[
362,
1,
998
]
],
[
[
482,
24,
97
],
[
97,
40,
998
]
],
[
[
482,
63,
168
],
[
168,
23,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenylbutazone (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) resembles Phenylbutazone (Compou... |
DB00987 | DB04865 | 1,224 | 4 | [
"DDInter460",
"DDInter1335"
] | Cytarabine | Omacetaxine mepesuccinate | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1224,
24,
4
]
],
[
[
1224,
18,
13042
],
[
13042,
46,
4
]
],
[
[
1224,
7,
6628
],
[
6628,
46,
4
]
],
[
[
1224,
18,
1917
],
[
1917,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Cytarabine",
"{u} (Compound) downregulates {v} (Gene)",
"HIST1H2BK"
],
[
"HIST1H2BK",
"{u} (Gene)... | Cytarabine (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cytarabine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cytarabine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is... |
DB00658 | DB01059 | 965 | 956 | [
"DDInter1663",
"DDInter1313"
] | Sevelamer | Norfloxacin | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
965,
24,
956
]
],
[
[
965,
24,
872
],
[
872,
40,
956
]
],
[
[
965,
63,
1176
],
[
1176,
1,
956
]
],
[
[
965,
24,
1539
],
[
1539,
... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Co... |
DB01242 | DB09065 | 1,237 | 760 | [
"DDInter410",
"DDInter424"
] | Clomipramine | Cobicistat | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1237,
24,
760
]
],
[
[
1237,
24,
1374
],
[
1374,
23,
760
]
],
[
[
1237,
25,
868
],
[
868,
24,
760
]
],
[
[
1237,
1,
1216
],
[
1216,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Clomipramine may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may ... |
DB01406 | DB04845 | 984 | 309 | [
"DDInter472",
"DDInter1001"
] | Danazol | Ixabepilone | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
984,
24,
309
]
],
[
[
984,
6,
8374
],
[
8374,
45,
309
]
],
[
[
984,
21,
28987
],
[
28987,
60,
309
]
],
[
[
984,
63,
1419
],
[
1419,
... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Danazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Danazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Danazol (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause ... |
DB00454 | DB12010 | 1,349 | 214 | [
"DDInter1150",
"DDInter785"
] | Meperidine | Fostamatinib | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1349,
24,
214
]
],
[
[
1349,
24,
976
],
[
976,
24,
214
]
],
[
[
1349,
25,
574
],
[
574,
24,
214
]
],
[
[
1349,
24,
1017
],
[
1017,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Meperidine may lead to a major life threatening interaction when taken with Alvimopan and Alvimopan may caus... |
DB00023 | DB00491 | 305 | 127 | [
"DDInter127",
"DDInter1217"
] | Asparaginase Escherichia coli | Miglitol | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Moderate | 1 | [
[
[
305,
24,
127
]
],
[
[
305,
24,
984
],
[
984,
63,
127
]
],
[
[
305,
24,
245
],
[
245,
24,
127
]
],
[
[
305,
25,
695
],
[
695,
24,... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Miglitol
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when ta... |
DB00352 | DB08895 | 482 | 976 | [
"DDInter1814",
"DDInter1825"
] | Tioguanine | Tofacitinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
482,
25,
976
]
],
[
[
482,
63,
1461
],
[
1461,
23,
976
]
],
[
[
482,
24,
214
],
[
214,
63,
976
]
],
[
[
482,
24,
998
],
[
998,
2... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostama... |
DB01044 | DB09407 | 246 | 853 | [
"DDInter809",
"DDInter1114"
] | Gatifloxacin | Magnesium chloride | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
246,
24,
853
]
],
[
[
246,
1,
1539
],
[
1539,
24,
853
]
],
[
[
246,
63,
544
],
[
544,
24,
853
]
],
[
[
246,
24,
460
],
[
460,
63... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Ofloxacin"
],
[
"Ofloxacin",
"{u} may cause... | Gatifloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderat... |
DB00939 | DB09472 | 1,338 | 1,383 | [
"DDInter1135",
"DDInter1693"
] | Meclofenamic acid | Sodium sulfate | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1338,
24,
1383
]
],
[
[
1338,
24,
1613
],
[
1613,
24,
1383
]
],
[
[
1338,
25,
1618
],
[
1618,
24,
1383
]
],
[
[
1338,
63,
912
],
[
912... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterf... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Meclofenamic acid may lead to a major life threatening interaction when taken w... |
DB00001 | DB00586 | 1,578 | 1,512 | [
"DDInter1037",
"DDInter537"
] | Lepirudin | Diclofenac | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
1578,
24,
1512
]
],
[
[
1578,
24,
1263
],
[
1263,
63,
1512
]
],
[
[
1578,
23,
297
],
[
297,
62,
1512
]
],
[
[
1578,
25,
1271
],
[
1271... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
],
[
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Lepirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a... |
DB00674 | DB08865 | 1,516 | 1,593 | [
"DDInter802",
"DDInter448"
] | Galantamine | Crizotinib | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1516,
24,
1593
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1516,
7,
10365
],
[
10365,
45,
1593
]
],
[
[
1516,
18,
15501
],
[
1... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Galantamine (Compound) upregulates STK10 (Gene) and STK10 (Gene) is bound by Crizotinib (Compound)
Galantamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Crizotinib (Compound)
Galantamine (Co... |
DB01156 | DB06637 | 593 | 1,109 | [
"DDInter252",
"DDInter468"
] | Bupropion | Dalfampridine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010. | Major | 2 | [
[
[
593,
25,
1109
]
],
[
[
593,
6,
6365
],
[
6365,
45,
1109
]
],
[
[
593,
21,
28880
],
[
28880,
60,
1109
]
],
[
[
593,
24,
1362
],
[
1362,... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalfampridine"
]
],
[
[
"Bupropion",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)",
"Dalfam... | Bupropion (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Dalfampridine (Compound)
Bupropion (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Dalfampridine (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and O... |
DB00467 | DB00570 | 1,467 | 147 | [
"DDInter644",
"DDInter1936"
] | Enoxacin | Vinblastine | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Minor | 0 | [
[
[
1467,
23,
147
]
],
[
[
1467,
62,
134
],
[
134,
24,
147
]
],
[
[
1467,
18,
9275
],
[
9275,
46,
147
]
],
[
[
1467,
7,
10439
],
[
10439,
... | [
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vinblastine"
]
],
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vinorelbine"
],
[
"V... | Enoxacin may cause a minor interaction that can limit clinical effects when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Enoxacin (Compound) downregulates RNF167 (Gene) and RNF167 (Gene) is upregulated by Vinblastine (Compound)
Enoxac... |
DB00988 | DB09038 | 817 | 1,450 | [
"DDInter584",
"DDInter636"
] | Dopamine | Empagliflozin | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
817,
24,
1450
]
],
[
[
817,
24,
659
],
[
659,
63,
1450
]
],
[
[
817,
40,
1551
],
[
1551,
24,
1450
]
],
[
[
817,
63,
1179
],
[
1179,
... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
... | Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Dopamine (Compound) resembles Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could ... |
DB00041 | DB00373 | 1,648 | 461 | [
"DDInter38",
"DDInter1809"
] | Aldesleukin | Timolol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Moderate | 1 | [
[
[
1648,
24,
461
]
],
[
[
1648,
24,
729
],
[
729,
40,
461
]
],
[
[
1648,
24,
278
],
[
278,
63,
461
]
],
[
[
1648,
24,
999
],
[
999,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Timolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic acid may cause a moderate interaction that co... |
DB00295 | DB00323 | 475 | 1,062 | [
"DDInter1244",
"DDInter1829"
] | Morphine | Tolcapone | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Moderate | 1 | [
[
[
475,
24,
1062
]
],
[
[
475,
24,
1533
],
[
1533,
40,
1062
]
],
[
[
475,
21,
29250
],
[
29250,
60,
1062
]
],
[
[
475,
24,
401
],
[
401,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolcapone"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entacapone"
],
[
"... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Entacapone and Entacapone (Compound) resembles Tolcapone (Compound)
Morphine (Compound) causes Polyuria (Side Effect) and Polyuria (Side Effect) is caused by Tolcapone (Compound)
Morphine may cause a moderate interaction that could... |
DB00005 | DB09121 | 1,057 | 1,328 | [
"DDInter687",
"DDInter140"
] | Etanercept | Aurothioglucose | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased si... | Moderate | 1 | [
[
[
1057,
24,
1328
]
],
[
[
1057,
24,
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],
[
367,
24,
1328
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],
[
[
1057,
25,
581
],
[
581,
24,
1328
]
],
[
[
1057,
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270
],
[
270,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aurothioglucose"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1"
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Etanercept may lead to a major life threatening interaction when taken with Infliximab ... |
DB06650 | DB11627 | 1,500 | 1,367 | [
"DDInter1324",
"DDInter860"
] | Ofatumumab | Hepatitis B Vaccine (Recombinant) | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1500,
24,
1367
]
],
[
[
1500,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
1500,
63,
259
],
[
259,
24,
1367
]
],
[
[
1500,
25,
375
],
[
375,
... | [
[
[
"Ofatumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Ofatumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
... | Ofatumumab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept an... |
DB00722 | DB09564 | 743 | 1,296 | [
"DDInter1079",
"DDInter930"
] | Lisinopril | Insulin degludec | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
743,
24,
1296
]
],
[
[
743,
25,
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],
[
1621,
23,
1296
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],
[
[
743,
25,
948
],
[
948,
62,
1296
]
],
[
[
743,
24,
1411
],
[
1411,
... | [
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Lisinopril",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
],
[
... | Lisinopril may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Lisinopril may lead to a major life threatening interaction when taken with Potassium gluconate and Potassi... |
DB00006 | DB01138 | 942 | 804 | [
"DDInter217",
"DDInter1726"
] | Bivalirudin | Sulfinpyrazone | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
942,
24,
804
]
],
[
[
942,
24,
998
],
[
998,
1,
804
]
],
[
[
942,
25,
582
],
[
582,
24,
804
]
],
[
[
942,
24,
1274
],
[
1274,
24... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Bivalirudin may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a moderate interaction that could ex... |
DB00307 | DB01076 | 1,101 | 700 | [
"DDInter202",
"DDInter133"
] | Bexarotene | Atorvastatin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
1101,
24,
700
]
],
[
[
1101,
23,
1080
],
[
1080,
1,
700
]
],
[
[
1101,
6,
6017
],
[
6017,
45,
700
]
],
[
[
1101,
25,
303
],
[
303,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Conivaptan"
],
[
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Bexarotene (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atorvastatin (Compound)
Bexarotene may lead to a major life threatening interaction when... |
DB01177 | DB11793 | 77 | 738 | [
"DDInter904",
"DDInter1297"
] | Idarubicin | Niraparib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
77,
24,
738
]
],
[
[
77,
24,
1213
],
[
1213,
24,
738
]
],
[
[
77,
24,
1033
],
[
1033,
63,
738
]
],
[
[
77,
63,
663
],
[
663,
24,... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib ... |
DB06168 | DB14783 | 1,531 | 287 | [
"DDInter281",
"DDInter574"
] | Canakinumab | Diroximel fumarate | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1531,
24,
287
]
],
[
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1531,
63,
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],
[
1101,
24,
287
]
],
[
[
1531,
24,
812
],
[
812,
24,
287
]
],
[
[
1531,
25,
1583
],
[
1583,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab ... |
DB00252 | DB12141 | 362 | 971 | [
"DDInter1460",
"DDInter817"
] | Phenytoin | Gilteritinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
362,
25,
971
]
],
[
[
362,
25,
1135
],
[
1135,
23,
971
]
],
[
[
362,
25,
466
],
[
466,
62,
971
]
],
[
[
362,
24,
112
],
[
112,
2... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Phenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Phenytoin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interac... |
DB00994 | DB09134 | 361 | 1,552 | [
"DDInter1277",
"DDInter966"
] | Neomycin | Ioversol | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
361,
25,
1552
]
],
[
[
361,
23,
699
],
[
699,
24,
1552
]
],
[
[
361,
24,
242
],
[
242,
63,
1552
]
],
[
[
361,
64,
1028
],
[
1028,
... | [
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Neomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nadolol"
],
[
"Nadolol",
"{u} ... | Neomycin may cause a minor interaction that can limit clinical effects when taken with Nadolol and Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause... |
DB01112 | DB09104 | 665 | 286 | [
"DDInter335",
"DDInter1118"
] | Cefuroxime | Magnesium hydroxide | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
665,
24,
286
]
],
[
[
665,
63,
752
],
[
752,
23,
286
]
],
[
[
665,
24,
1283
],
[
1283,
24,
286
]
],
[
[
665,
63,
1096
],
[
1096,
... | [
[
[
"Cefuroxime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Cefuroxime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],... | Cefuroxime may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Cefuroxime may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxid... |
DB00959 | DB15093 | 1,486 | 1,654 | [
"DDInter1191",
"DDInter1698"
] | Methylprednisolone | Somapacitan | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1486,
24,
1654
]
],
[
[
1486,
24,
433
],
[
433,
24,
1654
]
],
[
[
1486,
63,
176
],
[
176,
24,
1654
]
],
[
[
1486,
40,
1547
],
[
1547,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflo... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin and Ertugliflozin may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00570 | DB01263 | 147 | 859 | [
"DDInter1936",
"DDInter1494"
] | Vinblastine | Posaconazole | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Major | 2 | [
[
[
147,
25,
859
]
],
[
[
147,
6,
4973
],
[
4973,
45,
859
]
],
[
[
147,
21,
28762
],
[
28762,
60,
859
]
],
[
[
147,
24,
112
],
[
112,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Posaconazole"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Posac... | Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Vinblastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole an... |
DB00446 | DB05679 | 597 | 1,683 | [
"DDInter351",
"DDInter1907"
] | Chloramphenicol | Ustekinumab | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
597,
24,
1683
]
],
[
[
597,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
597,
24,
281
],
[
281,
24,
1683
]
],
[
[
597,
63,
305
],
[
305,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Levamisole and... |
DB00470 | DB01324 | 530 | 178 | [
"DDInter601",
"DDInter1490"
] | Dronabinol | Polythiazide | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
530,
24,
178
]
],
[
[
530,
24,
674
],
[
674,
40,
178
]
],
[
[
530,
63,
323
],
[
323,
40,
178
]
],
[
[
530,
21,
28714
],
[
28714,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Compou... |
DB00041 | DB06282 | 1,648 | 516 | [
"DDInter38",
"DDInter1053"
] | Aldesleukin | Levocetirizine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1648,
24,
516
]
],
[
[
1648,
24,
614
],
[
614,
24,
516
]
],
[
[
1648,
24,
180
],
[
180,
63,
516
]
],
[
[
1648,
25,
695
],
[
695,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexmedetomidine"
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Dexmedetomidine and Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Olice... |
DB00436 | DB09112 | 323 | 1,455 | [
"DDInter179",
"DDInter1306"
] | Bendroflumethiazide | Nitrous acid | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
323,
24,
1455
]
],
[
[
323,
40,
674
],
[
674,
24,
1455
]
],
[
[
323,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
323,
24,
433
],
[
433,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiaz... | Bendroflumethiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin m... |
DB01157 | DB10316 | 304 | 334 | [
"DDInter1875",
"DDInter1248"
] | Trimetrexate | Mumps virus strain B level jeryl lynn live antigen | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
304,
25,
334
]
],
[
[
304,
64,
1057
],
[
1057,
25,
334
]
],
[
[
304,
25,
908
],
[
908,
25,
334
]
],
[
[
304,
63,
599
],
[
599,
2... | [
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Trimetrexate may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Trimetrexate may lead to a major life threatening interaction when taken with Golimumab and Golimuma... |
DB00992 | DB01050 | 842 | 848 | [
"DDInter1182",
"DDInter900"
] | Methyl aminolevulinate (topical) | Ibuprofen | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
842,
24,
848
]
],
[
[
842,
21,
28942
],
[
28942,
60,
848
]
],
[
[
842,
63,
1299
],
[
1299,
24,
848
]
],
[
[
842,
24,
178
],
[
178,
... | [
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Methyl aminolevulinate",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis bullous"
],
[
"Dermatitis b... | Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Methyl aminolevulinate (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Ibuprofen (Compound)
Methyl aminolevulinate may cause a moderate interaction that c... |
DB00313 | DB01105 | 556 | 222 | [
"DDInter1913",
"DDInter1665"
] | Valproic acid | Sibutramine | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
556,
24,
222
]
],
[
[
556,
6,
8374
],
[
8374,
45,
222
]
],
[
[
556,
21,
29215
],
[
29215,
60,
222
]
],
[
[
556,
24,
384
],
[
384,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Valproic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Valproic acid (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Sibutramine (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Idelal... |
DB01309 | DB08870 | 1,254 | 850 | [
"DDInter933",
"DDInter228"
] | Insulin glulisine | Brentuximab vedotin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1254,
24,
850
]
],
[
[
1254,
63,
1142
],
[
1142,
24,
850
]
],
[
[
1254,
24,
1033
],
[
1033,
63,
850
]
],
[
[
1254,
24,
651
],
[
651,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orli... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Al... |
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