drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00092 | DB06650 | 58 | 1,500 | [
"DDInter40",
"DDInter1324"
] | Alefacept | Ofatumumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Moderate | 1 | [
[
[
58,
24,
1500
]
],
[
[
58,
24,
270
],
[
270,
63,
1500
]
],
[
[
58,
24,
869
],
[
869,
24,
1500
]
],
[
[
58,
63,
1184
],
[
1184,
24... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofatumumab"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Ofatumumab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotec... |
DB01159 | DB05294 | 419 | 1,069 | [
"DDInter854",
"DDInter1917"
] | Halothane | Vandetanib | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
419,
25,
1069
]
],
[
[
419,
6,
1829
],
[
1829,
45,
1069
]
],
[
[
419,
62,
112
],
[
112,
23,
1069
]
],
[
[
419,
24,
659
],
[
659,
... | [
[
[
"Halothane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Halothane",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
"Vandetanib"
... | Halothane (Compound) binds ALB (Gene) and ALB (Gene) is bound by Vandetanib (Compound)
Halothane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Halothane may cause a mo... |
DB01181 | DB09488 | 1,532 | 103 | [
"DDInter906",
"DDInter23"
] | Ifosfamide | Acrivastine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1532,
24,
103
]
],
[
[
1532,
63,
1405
],
[
1405,
24,
103
]
],
[
[
1532,
24,
830
],
[
830,
24,
103
]
],
[
[
1532,
24,
418
],
[
418,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Phenindami... |
DB06772 | DB13007 | 310 | 1,060 | [
"DDInter259",
"DDInter642"
] | Cabazitaxel | Enfortumab vedotin | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
310,
24,
1060
]
],
[
[
310,
24,
1604
],
[
1604,
23,
1060
]
],
[
[
310,
24,
1593
],
[
1593,
24,
1060
]
],
[
[
310,
63,
1439
],
[
1439,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor and Lumacaftor may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib an... |
DB00278 | DB06209 | 291 | 256 | [
"DDInter117",
"DDInter1508"
] | Argatroban | Prasugrel | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
291,
25,
256
]
],
[
[
291,
6,
8374
],
[
8374,
45,
256
]
],
[
[
291,
21,
28681
],
[
28681,
60,
256
]
],
[
[
291,
23,
944
],
[
944,
... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Argatroban",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Prasugre... | Argatroban (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prasugrel (Compound)
Argatroban (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Argatroban may cause a minor interaction that can limit clinical effects when taken with Chamomile... |
DB00539 | DB06404 | 11 | 1,514 | [
"DDInter1837",
"DDInter869"
] | Toremifene | Human C1-esterase inhibitor | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Moderate | 1 | [
[
[
11,
24,
1514
]
],
[
[
11,
35,
1423
],
[
1423,
24,
1514
]
],
[
[
11,
24,
984
],
[
984,
24,
1514
]
],
[
[
11,
36,
888
],
[
888,
24... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human C1-esterase inhibitor"
]
],
[
[
"Toremifene",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate dise... | Toremifene (Compound) resembles Ospemifene (Compound) and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene and Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Toremifene may cause a moderate inter... |
DB00502 | DB01612 | 1,300 | 1,637 | [
"DDInter853",
"DDInter92"
] | Haloperidol | Amyl Nitrite | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1300,
24,
1637
]
],
[
[
1300,
64,
475
],
[
475,
24,
1637
]
],
[
[
1300,
25,
401
],
[
401,
24,
1637
]
],
[
[
1300,
24,
1376
],
[
1376,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphine... | Haloperidol may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Haloperidol may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate ... |
DB00852 | DB01579 | 1,445 | 341 | [
"DDInter1545",
"DDInter1439"
] | Pseudoephedrine | Phendimetrazine | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
1445,
24,
341
]
],
[
[
1445,
6,
2437
],
[
2437,
45,
341
]
],
[
[
1445,
21,
28662
],
[
28662,
60,
341
]
],
[
[
1445,
24,
959
],
[
959,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
"{u} (Gene) is bound by {... | Pseudoephedrine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Phendimetrazine (Compound)
Pseudoephedrine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Phendimetrazine (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00802 | DB04843 | 1,322 | 1,511 | [
"DDInter43",
"DDInter1149"
] | Alfentanil | Mepenzolate | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1322,
24,
1511
]
],
[
[
1322,
24,
537
],
[
537,
24,
1511
]
],
[
[
1322,
63,
262
],
[
262,
24,
1511
]
],
[
[
1322,
24,
649
],
[
649,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidiniu... |
DB00758 | DB09079 | 1,347 | 1,496 | [
"DDInter413",
"DDInter1296"
] | Clopidogrel | Nintedanib | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
1347,
24,
1496
]
],
[
[
1347,
25,
707
],
[
707,
24,
1496
]
],
[
[
1347,
24,
33
],
[
33,
24,
1496
]
],
[
[
1347,
63,
20
],
[
20,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Clopidogrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparo... | Clopidogrel may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may caus... |
DB00545 | DB00771 | 751 | 262 | [
"DDInter1548",
"DDInter397"
] | Pyridostigmine | Clidinium | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
751,
24,
262
]
],
[
[
751,
24,
1511
],
[
1511,
63,
262
]
],
[
[
751,
63,
19
],
[
19,
24,
262
]
],
[
[
751,
40,
1372
],
[
1372,
6... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine ... |
DB00261 | DB09068 | 702 | 1,427 | [
"DDInter93",
"DDInter1948"
] | Anagrelide | Vortioxetine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
702,
24,
1427
]
],
[
[
702,
25,
256
],
[
256,
24,
1427
]
],
[
[
702,
24,
477
],
[
477,
24,
1427
]
],
[
[
702,
64,
366
],
[
366,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel... | Anagrelide may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause ... |
DB01115 | DB04845 | 336 | 309 | [
"DDInter1291",
"DDInter1001"
] | Nifedipine | Ixabepilone | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
336,
24,
309
]
],
[
[
336,
6,
8374
],
[
8374,
45,
309
]
],
[
[
336,
21,
29269
],
[
29269,
60,
309
]
],
[
[
336,
63,
1419
],
[
1419,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Nifedipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Nifedipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Nifedipine (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Ixabepilone (Compound)
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00673 | DB01764 | 723 | 805 | [
"DDInter112",
"DDInter469"
] | Aprepitant | Dalfopristin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
723,
24,
805
]
],
[
[
723,
6,
8374
],
[
8374,
45,
805
]
],
[
[
723,
23,
222
],
[
222,
23,
805
]
],
[
[
723,
62,
1101
],
[
1101,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Aprepitant may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Aprepitant may c... |
DB00563 | DB15091 | 663 | 676 | [
"DDInter1174",
"DDInter1901"
] | Methotrexate | Upadacitinib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
663,
25,
676
]
],
[
[
663,
63,
1461
],
[
1461,
23,
676
]
],
[
[
663,
24,
1430
],
[
1430,
24,
676
]
],
[
[
663,
25,
1249
],
[
1249,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitam... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Si... |
DB00078 | DB09075 | 1,172 | 498 | [
"DDInter898",
"DDInter621"
] | Ibritumomab tiuxetan | Edoxaban | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
1172,
25,
498
]
],
[
[
1172,
23,
944
],
[
944,
62,
498
]
],
[
[
1172,
24,
41
],
[
41,
24,
498
]
],
[
[
1172,
24,
738
],
[
738,
6... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Levomilna... |
DB00682 | DB11581 | 126 | 1,456 | [
"DDInter1951",
"DDInter1926"
] | Warfarin | Venetoclax | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
126,
24,
1456
]
],
[
[
126,
64,
536
],
[
536,
24,
1456
]
],
[
[
126,
24,
259
],
[
259,
24,
1456
]
],
[
[
126,
25,
984
],
[
984,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Secobarbital"
],
[
"Secobarbital... | Warfarin may lead to a major life threatening interaction when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause ... |
DB00959 | DB08912 | 1,486 | 1,040 | [
"DDInter1191",
"DDInter462"
] | Methylprednisolone | Dabrafenib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1486,
24,
1040
]
],
[
[
1486,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1486,
7,
3163
],
[
3163,
46,
1040
]
],
[
[
1486,
18,
20113
],
[
201... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v... | Methylprednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Methylprednisolone (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Dabrafenib (Compound)
Methylprednisolone (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Dabrafenib (... |
DB01168 | DB01364 | 1,053 | 22 | [
"DDInter1526",
"DDInter650"
] | Procarbazine | Ephedrine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Major | 2 | [
[
[
1053,
25,
22
]
],
[
[
1053,
64,
80
],
[
80,
24,
22
]
],
[
[
1053,
25,
1529
],
[
1529,
63,
22
]
],
[
[
1053,
25,
280
],
[
280,
1,... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ephedrine"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amphetamine"
],
[
"Amphetamine",
"... | Procarbazine may lead to a major life threatening interaction when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Procarbazine may lead to a major life threatening interaction when taken with Metamfetamine and Metamfetamine may cause a mo... |
DB00247 | DB08865 | 1,131 | 1,593 | [
"DDInter1194",
"DDInter448"
] | Methysergide | Crizotinib | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
1131,
24,
1593
]
],
[
[
1131,
21,
29093
],
[
29093,
60,
1593
]
],
[
[
1131,
24,
283
],
[
283,
62,
1593
]
],
[
[
1131,
40,
826
],
[
826... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Methysergide",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) is caus... | Methysergide (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Crizotini... |
DB00726 | DB01611 | 1,164 | 1,487 | [
"DDInter1876",
"DDInter893"
] | Trimipramine | Hydroxychloroquine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1164,
25,
1487
]
],
[
[
1164,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
1164,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1164,
21,
28658
],
[
... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Trimipramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Trimipramine ... |
DB01170 | DB01364 | 1,150 | 22 | [
"DDInter846",
"DDInter650"
] | Guanethidine | Ephedrine | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1150,
24,
22
]
],
[
[
1150,
63,
1445
],
[
1445,
1,
22
]
],
[
[
1150,
6,
7390
],
[
7390,
45,
22
]
],
[
[
1150,
24,
1220
],
[
1220,
... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Ephedrine (Compound)
Guanethidine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Ephedrine (Compound)
Guanethidine may cause a moderate interaction that cou... |
DB00414 | DB00877 | 590 | 629 | [
"DDInter16",
"DDInter1678"
] | Acetohexamide | Sirolimus | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
590,
24,
629
]
],
[
[
590,
24,
1438
],
[
1438,
24,
629
]
],
[
[
590,
24,
1476
],
[
1476,
63,
629
]
],
[
[
590,
63,
1645
],
[
1645,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Bri... |
DB00420 | DB08899 | 508 | 129 | [
"DDInter1532",
"DDInter649"
] | Promazine | Enzalutamide | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
508,
24,
129
]
],
[
[
508,
24,
918
],
[
918,
1,
129
]
],
[
[
508,
6,
8374
],
[
8374,
45,
129
]
],
[
[
508,
23,
112
],
[
112,
23,... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Promazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Promazine may cause a minor interaction that can limit clini... |
DB01069 | DB01128 | 401 | 918 | [
"DDInter1533",
"DDInter204"
] | Promethazine | Bicalutamide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
401,
24,
918
]
],
[
[
401,
24,
129
],
[
129,
40,
918
]
],
[
[
401,
6,
12523
],
[
12523,
45,
918
]
],
[
[
401,
21,
28642
],
[
28642,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Promethazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bicalutamide (Compound)
Promethazine (Compound) causes Shock (Side Effect) and... |
DB00490 | DB11979 | 946 | 1,320 | [
"DDInter254",
"DDInter625"
] | Buspirone | Elagolix | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
946,
24,
1320
]
],
[
[
946,
25,
129
],
[
129,
24,
1320
]
],
[
[
946,
24,
484
],
[
484,
63,
1320
]
],
[
[
946,
24,
1213
],
[
1213,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide... | Buspirone may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may caus... |
DB01235 | DB09241 | 1,191 | 1,629 | [
"DDInter1054",
"DDInter1186"
] | Levodopa | Methylene blue | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1191,
25,
1629
]
],
[
[
1191,
74,
1148
],
[
1148,
24,
1629
]
],
[
[
1191,
40,
584
],
[
584,
24,
1629
]
],
[
[
1191,
63,
874
],
[
874,
... | [
[
[
"Levodopa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Levodopa",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Levodopa (Compound) resembles Isoprenaline (Compound) and Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Levodopa (Compound) resembles Levonordefrin (Com... |
DB00370 | DB00604 | 1,251 | 1,425 | [
"DDInter1230",
"DDInter385"
] | Mirtazapine | Cisapride | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Major | 2 | [
[
[
1251,
25,
1425
]
],
[
[
1251,
24,
1311
],
[
1311,
1,
1425
]
],
[
[
1251,
6,
6962
],
[
6962,
45,
1425
]
],
[
[
1251,
23,
112
],
[
112,
... | [
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"Metoc... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Cisapride (Compound)
Mirtazapine (Compound) binds HTR2B (Gene) and HTR2B (Gene) is bound by Cisapride (Compound)
Mirtazapine may cause a minor interaction that can limit cli... |
DB00877 | DB12095 | 629 | 179 | [
"DDInter1678",
"DDInter1760"
] | Sirolimus | Telotristat ethyl | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
629,
24,
179
]
],
[
[
629,
63,
79
],
[
79,
24,
179
]
],
[
[
629,
24,
310
],
[
310,
24,
179
]
],
[
[
629,
24,
283
],
[
283,
63,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Ca... |
DB00321 | DB00572 | 21 | 85 | [
"DDInter78",
"DDInter136"
] | Amitriptyline | Atropine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
21,
24,
85
]
],
[
[
21,
25,
290
],
[
290,
40,
85
]
],
[
[
21,
24,
19
],
[
19,
24,
85
]
],
[
[
21,
6,
7950
],
[
7950,
45,
8... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
],
[
"Cocaine",... | Amitriptyline may lead to a major life threatening interaction when taken with Cocaine and Cocaine (Compound) resembles Atropine (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate dis... |
DB01073 | DB01118 | 1,488 | 33 | [
"DDInter745",
"DDInter76"
] | Fludarabine | Amiodarone | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
1488,
24,
33
]
],
[
[
1488,
21,
28681
],
[
28681,
60,
33
]
],
[
[
1488,
63,
597
],
[
597,
24,
33
]
],
[
[
1488,
24,
1683
],
[
1683,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Fludarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side... | Fludarabine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Amiodarone (Compound)
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseas... |
DB01254 | DB08868 | 1,213 | 1,011 | [
"DDInter484",
"DDInter737"
] | Dasatinib | Fingolimod | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1213,
25,
1011
]
],
[
[
1213,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
1213,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
1213,
62,
1247
],
[
1... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Dasatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingolimo... | Dasatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Dasatinib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Dasatinib may cause a minor interaction that can limit clinical effects when tak... |
DB00978 | DB06203 | 739 | 1,002 | [
"DDInter1084",
"DDInter51"
] | Lomefloxacin | Alogliptin | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
739,
24,
1002
]
],
[
[
739,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
739,
21,
29340
],
[
29340,
60,
1002
]
],
[
[
739,
24,
401
],
[
401,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Lomefloxacin (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Alogliptin (Compound)
Lomeflox... |
DB00701 | DB00911 | 1,091 | 458 | [
"DDInter90",
"DDInter1811"
] | Amprenavir | Tinidazole | Amprenavir is a protease inhibitor used to treat HIV infection. | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Major | 2 | [
[
[
1091,
25,
458
]
],
[
[
1091,
25,
112
],
[
112,
1,
458
]
],
[
[
1091,
6,
8374
],
[
8374,
45,
458
]
],
[
[
1091,
21,
29340
],
[
29340,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinidazole"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metronidazole"
],
[
"Metronidazole",
... | Amprenavir may lead to a major life threatening interaction when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Amprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tinidazole (Compound)
Amprenavir (Compound) causes Stevens-Johnson syndrome (Side Effect) and Ste... |
DB00841 | DB13928 | 532 | 1,385 | [
"DDInter577",
"DDInter1660"
] | Dobutamine | Semaglutide | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
532,
24,
1385
]
],
[
[
532,
63,
73
],
[
73,
24,
1385
]
],
[
[
532,
24,
1148
],
[
1148,
24,
1385
]
],
[
[
532,
1,
817
],
[
817,
2... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
[
... | Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and I... |
DB01128 | DB01182 | 918 | 371 | [
"DDInter204",
"DDInter1534"
] | Bicalutamide | Propafenone | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
918,
24,
371
]
],
[
[
918,
63,
847
],
[
847,
1,
371
]
],
[
[
918,
23,
271
],
[
271,
1,
371
]
],
[
[
918,
63,
675
],
[
675,
40,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron (Compound) resembles Propafenone (Comp... |
DB00031 | DB01009 | 20 | 935 | [
"DDInter1764",
"DDInter1009"
] | Tenecteplase | Ketoprofen | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
20,
24,
935
]
],
[
[
20,
24,
1274
],
[
1274,
24,
935
]
],
[
[
20,
24,
1263
],
[
1263,
1,
935
]
],
[
[
20,
25,
1046
],
[
1046,
63... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and... |
DB09143 | DB14575 | 313 | 733 | [
"DDInter1701",
"DDInter674"
] | Sonidegib | Eslicarbazepine | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
313,
24,
733
]
],
[
[
313,
63,
1101
],
[
1101,
23,
733
]
],
[
[
313,
25,
351
],
[
351,
24,
733
]
],
[
[
313,
24,
710
],
[
710,
2... | [
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[... | Sonidegib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Sonidegib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause... |
DB00218 | DB00443 | 1,176 | 251 | [
"DDInter1247",
"DDInter195"
] | Moxifloxacin | Betamethasone | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Major | 2 | [
[
[
1176,
25,
251
]
],
[
[
1176,
25,
870
],
[
870,
1,
251
]
],
[
[
1176,
25,
1486
],
[
1486,
40,
251
]
],
[
[
1176,
21,
28857
],
[
28857,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
],
[
"Fludrocortiso... | Moxifloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamethasone (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone (Compound) resembles Betamethasone (Comp... |
DB00087 | DB11793 | 599 | 738 | [
"DDInter41",
"DDInter1297"
] | Alemtuzumab | Niraparib | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
599,
24,
738
]
],
[
[
599,
24,
1213
],
[
1213,
24,
738
]
],
[
[
599,
63,
1253
],
[
1253,
24,
738
]
],
[
[
599,
24,
1619
],
[
1619,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifer... |
DB00604 | DB12332 | 1,425 | 1,619 | [
"DDInter385",
"DDInter1626"
] | Cisapride | Rucaparib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
1425,
25,
1619
]
],
[
[
1425,
24,
307
],
[
307,
23,
1619
]
],
[
[
1425,
23,
112
],
[
112,
23,
1619
]
],
[
[
1425,
64,
87
],
[
87,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazol... |
DB00584 | DB09146 | 610 | 489 | [
"DDInter638",
"DDInter978"
] | Enalapril | Iron sucrose | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
610,
24,
489
]
],
[
[
610,
1,
1058
],
[
1058,
24,
489
]
],
[
[
610,
40,
743
],
[
743,
24,
489
]
],
[
[
610,
1,
1058
],
[
1058,
1... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Enalapril",
"{u} (Compound) resembles {v} (Compound)",
"Moexipril"
],
[
"Moexipril",
"{u} may cause a moderate ... | Enalapril (Compound) resembles Moexipril (Compound) and Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Enalapril (Compound) resembles Lisinopril (Compound) and Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
... |
DB01320 | DB08896 | 651 | 292 | [
"DDInter783",
"DDInter1576"
] | Fosphenytoin | Regorafenib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
651,
24,
292
]
],
[
[
651,
63,
79
],
[
79,
1,
292
]
],
[
[
651,
6,
6017
],
[
6017,
45,
292
]
],
[
[
651,
21,
28658
],
[
28658,
6... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Fosphenytoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Fosphenytoin (Compound) causes Vomiting (Side Effect) and Vomi... |
DB00041 | DB00629 | 1,648 | 390 | [
"DDInter38",
"DDInter844"
] | Aldesleukin | Guanabenz | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem] | Moderate | 1 | [
[
[
1648,
24,
390
]
],
[
[
1648,
24,
1364
],
[
1364,
40,
390
]
],
[
[
1648,
24,
1220
],
[
1220,
63,
390
]
],
[
[
1648,
24,
999
],
[
999,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanabenz"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanfacine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Guanfacine and Guanfacine (Compound) resembles Guanabenz (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction tha... |
DB01206 | DB06168 | 37 | 1,531 | [
"DDInter1086",
"DDInter281"
] | Lomustine | Canakinumab | An alkylating agent of value against both hematologic malignancies and solid tumors. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
37,
24,
1531
]
],
[
[
37,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
37,
63,
377
],
[
377,
24,
1531
]
],
[
[
37,
24,
1270
],
[
1270,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin ma... |
DB00835 | DB01178 | 100 | 369 | [
"DDInter245",
"DDInter357"
] | Brompheniramine | Chlormezanone | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Moderate | 1 | [
[
[
100,
24,
369
]
],
[
[
100,
24,
1532
],
[
1532,
63,
369
]
],
[
[
100,
35,
272
],
[
272,
24,
369
]
],
[
[
100,
63,
13
],
[
13,
24,... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlormezanone"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Brompheniramine (Compound) resembles Chlorpheniramine (Compound) and Brompheniramine may cause a moderat... |
DB00603 | DB00675 | 303 | 888 | [
"DDInter1137",
"DDInter1744"
] | Medroxyprogesterone acetate | Tamoxifen | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Minor | 0 | [
[
[
303,
23,
888
]
],
[
[
303,
10,
11579
],
[
11579,
44,
888
]
],
[
[
303,
6,
1971
],
[
1971,
45,
888
]
],
[
[
303,
7,
7669
],
[
7669,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tamoxifen"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) palliates {v} (Disease)",
"breast cancer"
],
[
"breast can... | Medroxyprogesterone acetate (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is treated by Tamoxifen (Compound)
Medroxyprogesterone acetate (Compound) binds ESR1 (Gene) and ESR1 (Gene) is bound by Tamoxifen (Compound)
Medroxyprogesterone acetate (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gen... |
DB00519 | DB08907 | 1,638 | 1,344 | [
"DDInter1843",
"DDInter280"
] | Trandolapril | Canagliflozin | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1638,
24,
1344
]
],
[
[
1638,
24,
549
],
[
549,
1,
1344
]
],
[
[
1638,
21,
28962
],
[
28962,
60,
1344
]
],
[
[
1638,
24,
1486
],
[
148... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Trandolapril (Compound) causes Hyperkalaemia (Side Effect) and Hyperkalaemia (Side Effect) is caused by Canagliflozin (Compound)
Trandolapril may cau... |
DB00443 | DB01165 | 251 | 1,539 | [
"DDInter195",
"DDInter1325"
] | Betamethasone | Ofloxacin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
251,
25,
1539
]
],
[
[
251,
25,
1467
],
[
1467,
1,
1539
]
],
[
[
251,
64,
1176
],
[
1176,
1,
1539
]
],
[
[
251,
25,
945
],
[
945,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxacin"
],
[
"Enoxacin",
"{u} ... | Betamethasone may lead to a major life threatening interaction when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Betamethasone may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Betamethasone may lead to ... |
DB06204 | DB06764 | 768 | 1,090 | [
"DDInter1746",
"DDInter1787"
] | Tapentadol | Tetryzoline (nasal) | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
768,
24,
1090
]
],
[
[
768,
24,
144
],
[
144,
63,
1090
]
],
[
[
768,
63,
688
],
[
688,
24,
1090
]
],
[
[
768,
64,
222
],
[
222,
... | [
[
[
"Tapentadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Tapentadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
[
... | Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Tapentad... |
DB00757 | DB00844 | 1,166 | 314 | [
"DDInter581",
"DDInter1257"
] | Dolasetron | Nalbuphine | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
1166,
24,
314
]
],
[
[
1166,
63,
828
],
[
828,
40,
314
]
],
[
[
1166,
63,
421
],
[
421,
1,
314
]
],
[
[
1166,
63,
475
],
[
475,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (Compou... |
DB00682 | DB01022 | 126 | 1,484 | [
"DDInter1951",
"DDInter1461"
] | Warfarin | Phylloquinone | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders d... | Moderate | 1 | [
[
[
126,
24,
1484
]
],
[
[
126,
63,
1461
],
[
1461,
40,
1484
]
],
[
[
126,
24,
1142
],
[
1142,
62,
1484
]
],
[
[
126,
24,
166
],
[
166,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phylloquinone"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E (Compound) resembles Phylloquinone (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a minor interaction that can limit clini... |
DB00627 | DB06203 | 265 | 1,002 | [
"DDInter1286",
"DDInter51"
] | Niacin | Alogliptin | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
265,
24,
1002
]
],
[
[
265,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
265,
6,
12523
],
[
12523,
45,
1002
]
],
[
[
265,
21,
28778
],
[
2877... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
"Li... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Niacin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Alogliptin (Compound)
Niacin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylact... |
DB00366 | DB00660 | 1,594 | 1,470 | [
"DDInter600",
"DDInter1163"
] | Doxylamine | Metaxalone | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Moderate | 1 | [
[
[
1594,
24,
1470
]
],
[
[
1594,
7,
2692
],
[
2692,
46,
1470
]
],
[
[
1594,
21,
28681
],
[
28681,
60,
1470
]
],
[
[
1594,
24,
537
],
[
53... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metaxalone"
]
],
[
[
"Doxylamine",
"{u} (Compound) upregulates {v} (Gene)",
"KIT"
],
[
"KIT",
"{u} (Gene) is upregulated by {v} (Compo... | Doxylamine (Compound) upregulates KIT (Gene) and KIT (Gene) is upregulated by Metaxalone (Compound)
Doxylamine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Metaxalone (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00512 | DB00526 | 91 | 1,555 | [
"DDInter1916",
"DDInter1355"
] | Vancomycin | Oxaliplatin | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
91,
24,
1555
]
],
[
[
91,
24,
97
],
[
97,
63,
1555
]
],
[
[
91,
63,
598
],
[
598,
24,
1555
]
],
[
[
91,
25,
629
],
[
629,
63,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumet... |
DB01024 | DB14444 | 1,096 | 151 | [
"DDInter1252",
"DDInter924"
] | Mycophenolic acid | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1096,
24,
151
]
],
[
[
1096,
63,
66
],
[
66,
24,
151
]
],
[
[
1096,
25,
375
],
[
375,
24,
151
]
],
[
[
1096,
24,
1531
],
[
1531,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interactio... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Mycophenolic acid may lead to ... |
DB00991 | DB06754 | 97 | 707 | [
"DDInter1358",
"DDInter471"
] | Oxaprozin | Danaparoid | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
97,
25,
707
]
],
[
[
97,
63,
121
],
[
121,
24,
707
]
],
[
[
97,
24,
222
],
[
222,
24,
707
]
],
[
[
97,
24,
738
],
[
738,
63,
... | [
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
[
"Fenflurami... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sib... |
DB00087 | DB06616 | 599 | 594 | [
"DDInter41",
"DDInter224"
] | Alemtuzumab | Bosutinib | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
599,
24,
594
]
],
[
[
599,
24,
713
],
[
713,
63,
594
]
],
[
[
599,
24,
663
],
[
663,
24,
594
]
],
[
[
599,
63,
1257
],
[
1257,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Methot... |
DB00004 | DB08868 | 669 | 1,011 | [
"DDInter499",
"DDInter737"
] | Denileukin diftitox | Fingolimod | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
669,
25,
1011
]
],
[
[
669,
24,
748
],
[
748,
63,
1011
]
],
[
[
669,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
669,
25,
976
],
[
976,
... | [
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when take... |
DB00801 | DB09154 | 1,563 | 1,475 | [
"DDInter850",
"DDInter1686"
] | Halazepam | Sodium citrate | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Minor | 0 | [
[
[
1563,
23,
1475
]
],
[
[
1563,
1,
902
],
[
902,
23,
1475
]
],
[
[
1563,
40,
523
],
[
523,
23,
1475
]
],
[
[
1563,
24,
478
],
[
478,
... | [
[
[
"Halazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium citrate"
]
],
[
[
"Halazepam",
"{u} (Compound) resembles {v} (Compound)",
"Clobazam"
],
[
"Clobazam",
"{u} may cause a minor inter... | Halazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Halazepam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Ha... |
DB00065 | DB15762 | 581 | 725 | [
"DDInter923",
"DDInter1644"
] | Infliximab | Satralizumab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Major | 2 | [
[
[
581,
25,
725
]
],
[
[
581,
23,
1193
],
[
1193,
23,
725
]
],
[
[
581,
25,
1362
],
[
1362,
24,
725
]
],
[
[
581,
24,
303
],
[
303,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc g... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Satralizumab
Infliximab may lead to a major life threatening interaction when taken with Olaparib and Olaparib may caus... |
DB04868 | DB14409 | 478 | 1,129 | [
"DDInter1293",
"DDInter867"
] | Nilotinib | Human adenovirus e serotype 4 strain cl-68578 antigen | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
478,
24,
1129
]
],
[
[
478,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
478,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
478,
63,
134
],
[
134,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"E... | Nilotinib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00685 | DB11126 | 1,299 | 900 | [
"DDInter1887",
"DDInter276"
] | Trovafloxacin | Calcium gluconate | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
1299,
24,
900
]
],
[
[
1299,
1,
739
],
[
739,
24,
900
]
],
[
[
1299,
1,
739
],
[
739,
1,
945
],
[
945,
24,
900
]
],
[
[
1299,
1,... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u} ma... | Trovafloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Trovafloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may caus... |
DB01400 | DB09268 | 1,372 | 1,662 | [
"DDInter1279",
"DDInter1464"
] | Neostigmine | Picosulfuric acid | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1372,
24,
1662
]
],
[
[
1372,
63,
708
],
[
708,
24,
1662
]
],
[
[
1372,
24,
1593
],
[
1593,
24,
1662
]
],
[
[
1372,
64,
593
],
[
593,
... | [
[
[
"Neostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Neostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
... | Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Crizot... |
DB00254 | DB00258 | 964 | 666 | [
"DDInter598",
"DDInter270"
] | Doxycycline | Calcium acetate | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Moderate | 1 | [
[
[
964,
24,
666
]
],
[
[
964,
23,
1605
],
[
1605,
63,
666
]
],
[
[
964,
1,
1545
],
[
1545,
63,
666
]
],
[
[
964,
24,
1252
],
[
1252,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium acetate"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
],
... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Indapamide and Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Calcium acetate
Doxycycline (Compound) resembles Oxytetracycline (Compound) and Oxytetracycline may cause a moderate interac... |
DB01017 | DB01592 | 1,669 | 1,596 | [
"DDInter1224",
"DDInter975"
] | Minocycline | Iron | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1669,
24,
1596
]
],
[
[
1669,
24,
1193
],
[
1193,
62,
1596
]
],
[
[
1669,
24,
1096
],
[
1096,
23,
1596
]
],
[
[
1669,
63,
955
],
[
955... | [
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[
... | Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Iron
Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid a... |
DB00363 | DB01166 | 695 | 477 | [
"DDInter419",
"DDInter379"
] | Clozapine | Cilostazol | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
695,
25,
477
]
],
[
[
695,
6,
8374
],
[
8374,
45,
477
]
],
[
[
695,
23,
112
],
[
112,
23,
477
]
],
[
[
695,
24,
126
],
[
126,
23... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cilostazo... | Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Clozapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Clozapine may caus... |
DB01261 | DB09381 | 170 | 192 | [
"DDInter1679",
"DDInter678"
] | Sitagliptin | Esterified estrogens | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
170,
24,
192
]
],
[
[
170,
24,
1019
],
[
1019,
63,
192
]
],
[
[
170,
63,
1685
],
[
1685,
24,
192
]
],
[
[
170,
24,
1040
],
[
1040,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin... |
DB00059 | DB06777 | 1,560 | 780 | [
"DDInter1404",
"DDInter348"
] | Pegaspargase | Chenodeoxycholic acid | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Moderate | 1 | [
[
[
1560,
24,
780
]
],
[
[
1560,
24,
279
],
[
279,
24,
780
]
],
[
[
1560,
24,
384
],
[
384,
63,
780
]
],
[
[
1560,
25,
1510
],
[
1510,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chenodeoxycholic acid"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Chenodeoxycholic acid
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Idel... |
DB06186 | DB09115 | 1,439 | 505 | [
"DDInter969",
"DDInter559"
] | Ipilimumab | Diiodohydroxyquinoline | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
1439,
24,
505
]
],
[
[
1439,
24,
1593
],
[
1593,
24,
505
]
],
[
[
1439,
63,
467
],
[
467,
24,
505
]
],
[
[
1439,
25,
1510
],
[
1510,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Simvastat... |
DB00363 | DB00916 | 695 | 112 | [
"DDInter419",
"DDInter1202"
] | Clozapine | Metronidazole | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
695,
23,
112
]
],
[
[
695,
6,
3486
],
[
3486,
45,
112
]
],
[
[
695,
40,
87
],
[
87,
23,
112
]
],
[
[
695,
64,
618
],
[
618,
23,
... | [
[
[
"Clozapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Clozapine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Clozapine (Compound) resembles Amoxapine (Compound) and Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Clozapine may lead to a major life threatening interaction when ta... |
DB00836 | DB00843 | 543 | 479 | [
"DDInter1088",
"DDInter583"
] | Loperamide | Donepezil | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
543,
24,
479
]
],
[
[
543,
24,
843
],
[
843,
1,
479
]
],
[
[
543,
6,
12523
],
[
12523,
45,
479
]
],
[
[
543,
18,
2183
],
[
2183,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
],
[
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Loperamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Loperamide (Compound) downregulates CDC20 (Gene) and CDC20 (Ge... |
DB00063 | DB00812 | 366 | 998 | [
"DDInter659",
"DDInter1451"
] | Eptifibatide | Phenylbutazone | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
366,
24,
998
]
],
[
[
366,
24,
97
],
[
97,
40,
998
]
],
[
[
366,
24,
1061
],
[
1061,
24,
998
]
],
[
[
366,
63,
942
],
[
942,
24,... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
],
... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) resembles Phenylbutazone (Compound)
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction ... |
DB05316 | DB09268 | 749 | 1,662 | [
"DDInter1467",
"DDInter1464"
] | Pimavanserin | Picosulfuric acid | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
749,
24,
1662
]
],
[
[
749,
24,
484
],
[
484,
63,
1662
]
],
[
[
749,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
749,
63,
597
],
[
597,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
... | Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Pimavanserin may lead to a major life threatening interaction when taken with Cabozantinib and Caboza... |
DB00880 | DB01070 | 359 | 1,098 | [
"DDInter360",
"DDInter558"
] | Chlorothiazide | Dihydrotachysterol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
359,
24,
1098
]
],
[
[
359,
63,
386
],
[
386,
25,
1098
]
],
[
[
359,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
359,
24,
603
],
[
603,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalcif... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Paricalcit... |
DB00560 | DB09268 | 753 | 1,662 | [
"DDInter1805",
"DDInter1464"
] | Tigecycline | Picosulfuric acid | Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S. Food and Drug Administration (FDA) on June 17,... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
753,
24,
1662
]
],
[
[
753,
40,
964
],
[
964,
24,
1662
]
],
[
[
753,
40,
11393
],
[
11393,
40,
964
],
[
964,
24,
1662
]
],
[
[
753,
... | [
[
[
"Tigecycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Tigecycline",
"{u} (Compound) resembles {v} (Compound)",
"Doxycycline"
],
[
"Doxycycline",
"{u} may caus... | Tigecycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Tigecycline (Compound) resembles Clomocycline (Compound) and Clomocycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a mode... |
DB00532 | DB00650 | 208 | 1,147 | [
"DDInter1152",
"DDInter1041"
] | Mephenytoin | Leucovorin | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Moderate | 1 | [
[
[
208,
24,
1147
]
],
[
[
208,
63,
356
],
[
356,
1,
1147
]
],
[
[
208,
24,
50
],
[
50,
62,
1147
]
],
[
[
208,
24,
60
],
[
60,
64,
... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leucovorin"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Folic acid"
],
[
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Folic acid and Folic acid (Compound) resembles Leucovorin (Compound)
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a minor interaction that ... |
DB09104 | DB11642 | 286 | 938 | [
"DDInter1118",
"DDInter1480"
] | Magnesium hydroxide | Pitolisant | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
286,
24,
938
]
],
[
[
286,
63,
28
],
[
28,
24,
938
]
],
[
[
286,
62,
820
],
[
820,
24,
938
]
],
[
[
286,
24,
927
],
[
927,
63,
... | [
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl... | Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Alimema... |
DB00450 | DB01142 | 78 | 1,264 | [
"DDInter603",
"DDInter593"
] | Droperidol | Doxepin | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
78,
25,
1264
]
],
[
[
78,
25,
401
],
[
401,
24,
1264
]
],
[
[
78,
24,
832
],
[
832,
24,
1264
]
],
[
[
78,
63,
1594
],
[
1594,
24... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
"Promethazine",
"{u} ... | Droperidol may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine m... |
DB00408 | DB06282 | 1,408 | 516 | [
"DDInter1099",
"DDInter1053"
] | Loxapine | Levocetirizine | An antipsychotic agent used in schizophrenia. [PubChem] | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1408,
24,
516
]
],
[
[
1408,
63,
701
],
[
701,
24,
516
]
],
[
[
1408,
24,
1614
],
[
1614,
24,
516
]
],
[
[
1408,
40,
1178
],
[
1178,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone... |
DB00861 | DB01088 | 914 | 714 | [
"DDInter551",
"DDInter908"
] | Diflunisal | Iloprost | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
914,
24,
714
]
],
[
[
914,
24,
1479
],
[
1479,
24,
714
]
],
[
[
914,
63,
1432
],
[
1432,
24,
714
]
],
[
[
914,
24,
1564
],
[
1564,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Abc... |
DB00641 | DB01125 | 467 | 279 | [
"DDInter1675",
"DDInter98"
] | Simvastatin | Anisindione | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Minor | 0 | [
[
[
467,
23,
279
]
],
[
[
467,
24,
918
],
[
918,
62,
279
]
],
[
[
467,
24,
913
],
[
913,
63,
279
]
],
[
[
467,
24,
660
],
[
660,
24,... | [
[
[
"Simvastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Anisindione"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and ... |
DB00853 | DB01004 | 1,686 | 563 | [
"DDInter1762",
"DDInter806"
] | Temozolomide | Ganciclovir | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
1686,
24,
563
]
],
[
[
1686,
24,
248
],
[
248,
40,
563
]
],
[
[
1686,
21,
29169
],
[
29169,
60,
563
]
],
[
[
1686,
25,
770
],
[
770,
... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],... | Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Temozolomide (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Ganciclovir (Compound)
Temozolomide may lead to a major... |
DB00279 | DB08907 | 1,152 | 1,344 | [
"DDInter1074",
"DDInter280"
] | Liothyronine | Canagliflozin | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1152,
24,
1344
]
],
[
[
1152,
24,
549
],
[
549,
1,
1344
]
],
[
[
1152,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
1152,
21,
28766
],
[
28766... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Liothyronine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Liothyronine (Compound) causes Hypotension (Side Eff... |
DB01255 | DB06663 | 633 | 1,154 | [
"DDInter1078",
"DDInter1398"
] | Lisdexamfetamine | Pasireotide | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
633,
25,
1154
]
],
[
[
633,
21,
28898
],
[
28898,
60,
1154
]
],
[
[
633,
62,
112
],
[
112,
23,
1154
]
],
[
[
633,
63,
480
],
[
480,
... | [
[
[
"Lisdexamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Lisdexamfetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (Side Effect) is ... | Lisdexamfetamine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Pasireotide (Compound)
Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects wh... |
DB00647 | DB09080 | 675 | 144 | [
"DDInter528",
"DDInter1331"
] | Dextropropoxyphene | Olodaterol | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
675,
24,
144
]
],
[
[
675,
40,
371
],
[
371,
24,
144
]
],
[
[
675,
25,
1011
],
[
1011,
24,
144
]
],
[
[
675,
75,
11
],
[
11,
24,... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) resembles {v} (Compound)",
"Propafenone"
],
[
"Propafenone",
"{u} m... | Dextropropoxyphene (Compound) resembles Propafenone (Compound) and Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Dextropropoxyphene may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that co... |
DB00112 | DB09054 | 374 | 384 | [
"DDInter201",
"DDInter905"
] | Bevacizumab | Idelalisib | There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its at... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
374,
24,
384
]
],
[
[
374,
25,
38
],
[
38,
24,
384
]
],
[
[
374,
63,
1257
],
[
1257,
24,
384
]
],
[
[
374,
24,
869
],
[
869,
24,... | [
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Bevacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panitumumab"
],
[
"Panitum... | Bevacizumab may lead to a major life threatening interaction when taken with Panitumumab and Panitumumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim and Pegfilgrastim ... |
DB09322 | DB14004 | 1,114 | 398 | [
"DDInter1966",
"DDInter1806"
] | Zinc sulfate | Tildrakizumab | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Minor | 0 | [
[
[
1114,
23,
398
]
],
[
[
1114,
62,
58
],
[
58,
24,
398
]
],
[
[
1114,
23,
270
],
[
270,
24,
398
]
],
[
[
1114,
62,
375
],
[
375,
2... | [
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Zinc sulfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alefacept"
],
[
... | Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Tildrakizumab
Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab and Ocre... |
DB01097 | DB08868 | 1,377 | 1,011 | [
"DDInter1033",
"DDInter737"
] | Leflunomide | Fingolimod | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1377,
25,
1011
]
],
[
[
1377,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
1377,
63,
112
],
[
112,
23,
1011
]
],
[
[
1377,
24,
242
],
[
242... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
"{u} (S... | Leflunomide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit cl... |
DB01218 | DB14509 | 1,493 | 1,399 | [
"DDInter852",
"DDInter1081"
] | Halofantrine | Lithium carbonate | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
1493,
25,
1399
]
],
[
[
1493,
25,
1374
],
[
1374,
24,
1399
]
],
[
[
1493,
63,
506
],
[
506,
24,
1399
]
],
[
[
1493,
64,
1010
],
[
1010... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",... | Halofantrine may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and De... |
DB00328 | DB01099 | 831 | 1,272 | [
"DDInter921",
"DDInter744"
] | Indomethacin | Flucytosine | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
831,
24,
1272
]
],
[
[
831,
21,
29209
],
[
29209,
60,
1272
]
],
[
[
831,
24,
1448
],
[
1448,
24,
1272
]
],
[
[
831,
24,
712
],
[
712,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Indomethacin",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is c... | Indomethacin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00519 | DB14018 | 1,638 | 431 | [
"DDInter1843",
"DDInter244"
] | Trandolapril | Bromotheophylline | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. Bromotheophylline is categorized on the FDA as a ... | Moderate | 1 | [
[
[
1638,
24,
431
]
],
[
[
1638,
1,
1058
],
[
1058,
24,
431
]
],
[
[
1638,
63,
1061
],
[
1061,
24,
431
]
],
[
[
1638,
24,
714
],
[
714,
... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromotheophylline"
]
],
[
[
"Trandolapril",
"{u} (Compound) resembles {v} (Compound)",
"Moexipril"
],
[
"Moexipril",
"{u} may cause ... | Trandolapril (Compound) resembles Moexipril (Compound) and Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Bromotheophylline
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interacti... |
DB00994 | DB13886 | 361 | 125 | [
"DDInter1277",
"DDInter870"
] | Neomycin | Human cytomegalovirus immune globulin | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human popul... | Major | 2 | [
[
[
361,
25,
125
]
],
[
[
361,
24,
712
],
[
712,
25,
125
]
],
[
[
361,
64,
1481
],
[
1481,
25,
125
]
],
[
[
361,
63,
50
],
[
50,
25,... | [
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Human cytomegalovirus immune globulin"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Neomycin may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B ... |
DB06176 | DB08826 | 1,342 | 1,292 | [
"DDInter1616",
"DDInter489"
] | Romidepsin | Deferiprone | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1342,
25,
1292
]
],
[
[
1342,
24,
1017
],
[
1017,
63,
1292
]
],
[
[
1342,
24,
1619
],
[
1619,
64,
1292
]
],
[
[
1342,
63,
1236
],
[
12... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorlatini... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapa... |
DB11915 | DB14723 | 1,293 | 159 | [
"DDInter1909",
"DDInter1026"
] | Valbenazine | Larotrectinib | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1293,
24,
159
]
],
[
[
1293,
63,
222
],
[
222,
23,
159
]
],
[
[
1293,
63,
98
],
[
98,
24,
159
]
],
[
[
1293,
64,
11
],
[
11,
24,... | [
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Som... |
DB00515 | DB01249 | 589 | 258 | [
"DDInter387",
"DDInter958"
] | Cisplatin | Iodixanol | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
589,
25,
258
]
],
[
[
589,
25,
497
],
[
497,
1,
258
]
],
[
[
589,
21,
28719
],
[
28719,
60,
258
]
],
[
[
589,
24,
1680
],
[
1680,
... | [
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compound)... | Cisplatin may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Cisplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Iodixanol (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when ... |
DB00960 | DB11363 | 887 | 1,276 | [
"DDInter1471",
"DDInter39"
] | Pindolol | Alectinib | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
887,
24,
1276
]
],
[
[
887,
1,
819
],
[
819,
24,
1276
]
],
[
[
887,
25,
1011
],
[
1011,
24,
1276
]
],
[
[
887,
24,
1528
],
[
1528,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Pindolol",
"{u} (Compound) resembles {v} (Compound)",
"Acebutolol"
],
[
"Acebutolol",
"{u} may cause a moderate int... | Pindolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Pindolol may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases... |
DB00443 | DB00978 | 251 | 739 | [
"DDInter195",
"DDInter1084"
] | Betamethasone | Lomefloxacin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Major | 2 | [
[
[
251,
25,
739
]
],
[
[
251,
25,
945
],
[
945,
40,
739
]
],
[
[
251,
64,
1176
],
[
1176,
1,
739
]
],
[
[
251,
25,
1299
],
[
1299,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfloxacin",
... | Betamethasone may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Betamethasone may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin (Compound)
Betamethason... |
DB00436 | DB11827 | 323 | 433 | [
"DDInter179",
"DDInter669"
] | Bendroflumethiazide | Ertugliflozin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
323,
24,
433
]
],
[
[
323,
24,
959
],
[
959,
24,
433
]
],
[
[
323,
40,
1577
],
[
1577,
24,
433
]
],
[
[
323,
63,
1061
],
[
1061,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipiz... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Bendroflumethiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may caus... |
DB11718 | DB12001 | 927 | 564 | [
"DDInter640",
"DDInter7"
] | Encorafenib | Abemaciclib | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
927,
24,
564
]
],
[
[
927,
63,
536
],
[
536,
24,
564
]
],
[
[
927,
64,
868
],
[
868,
24,
564
]
],
[
[
927,
25,
982
],
[
982,
63,... | [
[
[
"Encorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Encorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
... | Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Encorafenib may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib m... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.