drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00041 | DB00774 | 1,648 | 1,577 | [
"DDInter38",
"DDInter889"
] | Aldesleukin | Hydroflumethiazide | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Moderate | 1 | [
[
[
1648,
24,
1577
]
],
[
[
1648,
24,
359
],
[
359,
40,
1577
]
],
[
[
1648,
24,
504
],
[
504,
1,
1577
]
],
[
[
1648,
24,
475
],
[
475,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compou... |
DB01009 | DB05578 | 935 | 330 | [
"DDInter1009",
"DDInter1566"
] | Ketoprofen | Ramucirumab | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
935,
25,
330
]
],
[
[
935,
24,
384
],
[
384,
63,
330
]
],
[
[
935,
1,
282
],
[
282,
63,
330
]
],
[
[
935,
24,
222
],
[
222,
24,
... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
"Idelalisi... | Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Ketoprofen (Compound) resembles Nepafenac (Compound) and Nepafenac may cause a moderate interaction that could ... |
DB00816 | DB01242 | 1,674 | 1,237 | [
"DDInter1346",
"DDInter410"
] | Orciprenaline | Clomipramine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1674,
24,
1237
]
],
[
[
1674,
64,
684
],
[
684,
1,
1237
]
],
[
[
1674,
63,
1164
],
[
1164,
1,
1237
]
],
[
[
1674,
24,
1630
],
[
1630,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"... | Orciprenaline may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compoun... |
DB00363 | DB09331 | 695 | 745 | [
"DDInter419",
"DDInter478"
] | Clozapine | Daratumumab | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Major | 2 | [
[
[
695,
25,
745
]
],
[
[
695,
25,
4
],
[
4,
24,
745
]
],
[
[
695,
64,
599
],
[
599,
24,
745
]
],
[
[
695,
25,
810
],
[
810,
63,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daratumumab"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
],
[
"Omacetaxine... | Clozapine may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Daratumumab
Clozapine may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtu... |
DB01035 | DB11986 | 1,401 | 484 | [
"DDInter1524",
"DDInter648"
] | Procainamide | Entrectinib | A derivative of procaine with less CNS action. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1401,
25,
484
]
],
[
[
1401,
62,
112
],
[
112,
23,
484
]
],
[
[
1401,
25,
774
],
[
774,
24,
484
]
],
[
[
1401,
64,
1674
],
[
1674,
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Procainamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Procainamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Procainamide may lead to a major life threatening interaction when taken with Degarelix and Degarelix may c... |
DB03619 | DB12364 | 557 | 1,421 | [
"DDInter501",
"DDInter200"
] | Deoxycholic acid | Betrixaban | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
557,
24,
1421
]
],
[
[
557,
24,
1496
],
[
1496,
24,
1421
]
],
[
[
557,
63,
714
],
[
714,
25,
1421
]
],
[
[
557,
24,
18
],
[
18,
... | [
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
... | Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost ... |
DB00697 | DB05294 | 876 | 1,069 | [
"DDInter1821",
"DDInter1917"
] | Tizanidine | Vandetanib | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
876,
25,
1069
]
],
[
[
876,
21,
28883
],
[
28883,
60,
1069
]
],
[
[
876,
23,
112
],
[
112,
23,
1069
]
],
[
[
876,
24,
659
],
[
659,
... | [
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Tizanidine",
"{u} (Compound) causes {v} (Side Effect)",
"Skin disorder"
],
[
"Skin disorder",
"{u} (Side Effect) is caused by {... | Tizanidine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Vandetanib (Compound)
Tizanidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wi... |
DB00352 | DB01181 | 482 | 1,532 | [
"DDInter1814",
"DDInter906"
] | Tioguanine | Ifosfamide | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
482,
24,
1532
]
],
[
[
482,
5,
11555
],
[
11555,
44,
1532
]
],
[
[
482,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
482,
23,
1299
],
[
129... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Tioguanine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Diseas... | Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Ifosfamide (Compound)
Tioguanine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Tioguanine may cause a minor interaction that can limit clinical effects when t... |
DB00431 | DB01191 | 1,503 | 1,039 | [
"DDInter1072",
"DDInter518"
] | Lindane | Dexfenfluramine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
1503,
24,
1039
]
],
[
[
1503,
24,
1529
],
[
1529,
64,
1039
]
],
[
[
1503,
24,
479
],
[
479,
23,
1039
]
],
[
[
1503,
24,
673
],
[
673,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may lead to a major life threatening interaction when taken with Dexfenfluramine
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cau... |
DB00987 | DB12674 | 1,224 | 975 | [
"DDInter460",
"DDInter1105"
] | Cytarabine | Lurbinectedin | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1224,
24,
975
]
],
[
[
1224,
35,
1488
],
[
1488,
24,
975
]
],
[
[
1224,
24,
1613
],
[
1613,
24,
975
]
],
[
[
1224,
74,
372
],
[
372,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Cytarabine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when take... | Cytarabine (Compound) resembles Fludarabine (Compound) and Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Cytarabine may cause a moderate interaction that... |
DB00083 | DB00283 | 677 | 701 | [
"DDInter225",
"DDInter395"
] | Botulinum toxin type A | Clemastine | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Moderate | 1 | [
[
[
677,
24,
701
]
],
[
[
677,
24,
85
],
[
85,
63,
701
]
],
[
[
677,
24,
352
],
[
352,
24,
701
]
],
[
[
677,
24,
1511
],
[
1511,
74,... | [
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]
],
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atr... | Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00108 | DB00853 | 1,066 | 1,686 | [
"DDInter1268",
"DDInter1762"
] | Natalizumab | Temozolomide | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Major | 2 | [
[
[
1066,
25,
1686
]
],
[
[
1066,
25,
970
],
[
970,
24,
1686
]
],
[
[
1066,
25,
1330
],
[
1330,
63,
1686
]
],
[
[
1066,
24,
496
],
[
496,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Temozolomide"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluorouracil"
],
[
"Fluorouracil",
... | Natalizumab may lead to a major life threatening interaction when taken with Fluorouracil and Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide
Natalizumab may lead to a major life threatening interaction when taken with Naxitamab and Naxitamab may cause a moderat... |
DB00526 | DB00976 | 1,555 | 1,056 | [
"DDInter1355",
"DDInter1758"
] | Oxaliplatin | Telithromycin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
1555,
24,
1056
]
],
[
[
1555,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
1555,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
1555,
24,
112
],
[
112,... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Oxaliplatin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Oxaliplatin may cause a moderate interaction that coul... |
DB00209 | DB00761 | 352 | 1,621 | [
"DDInter1886",
"DDInter1497"
] | Trospium | Potassium chloride | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
352,
25,
1621
]
],
[
[
352,
21,
28929
],
[
28929,
60,
1621
]
],
[
[
352,
24,
1105
],
[
1105,
25,
1621
]
],
[
[
352,
24,
667
],
[
667,
... | [
[
[
"Trospium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Trospium",
"{u} (Compound) causes {v} (Side Effect)",
"Confusional state"
],
[
"Confusional state",
"{u} (Side Effect) is... | Trospium (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Potassium chloride (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl may lead to a major life threatening interaction when tak... |
DB00620 | DB00655 | 175 | 559 | [
"DDInter1855",
"DDInter682"
] | Triamcinolone | Estrone | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Moderate | 1 | [
[
[
175,
24,
559
]
],
[
[
175,
24,
35
],
[
35,
40,
559
]
],
[
[
175,
40,
1581
],
[
1581,
40,
559
]
],
[
[
175,
63,
380
],
[
380,
40,... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
[... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Estrone (Compound)
Triamcinolone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Estrone (Compound)
Triamcinolone may cause a moderate interacti... |
DB01404 | DB06779 | 757 | 365 | [
"DDInter820",
"DDInter470"
] | Ginseng | Dalteparin | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
757,
24,
365
]
],
[
[
757,
63,
1018
],
[
1018,
25,
365
]
],
[
[
757,
24,
256
],
[
256,
25,
365
]
],
[
[
757,
24,
498
],
[
498,
6... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[
"... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Dalteparin
Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and Prasugrel may lead to a ma... |
DB00682 | DB06372 | 126 | 259 | [
"DDInter1951",
"DDInter1594"
] | Warfarin | Rilonacept | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
126,
24,
259
]
],
[
[
126,
63,
1461
],
[
1461,
23,
259
]
],
[
[
126,
24,
1619
],
[
1619,
63,
259
]
],
[
[
126,
63,
1573
],
[
1573,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may c... |
DB04868 | DB14975 | 478 | 988 | [
"DDInter1293",
"DDInter1949"
] | Nilotinib | Voxelotor | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
478,
24,
988
]
],
[
[
478,
63,
222
],
[
222,
23,
988
]
],
[
[
478,
23,
466
],
[
466,
23,
988
]
],
[
[
478,
63,
251
],
[
251,
24,... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Nilotinib may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutam... |
DB00723 | DB00907 | 1,240 | 290 | [
"DDInter1176",
"DDInter427"
] | Methoxamine | Cocaine (topical) | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Major | 2 | [
[
[
1240,
25,
290
]
],
[
[
1240,
24,
455
],
[
455,
64,
290
]
],
[
[
1240,
63,
1048
],
[
1048,
25,
290
]
],
[
[
1240,
24,
1674
],
[
1674,
... | [
[
[
"Methoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
"Salmeterol"... | Methoxamine may lead to a major life threatening interaction when taken with Cocaine
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may lead to a major life threatening interaction when taken with Cocaine
Methoxamine may cause a moderate interaction... |
DB00758 | DB01045 | 1,347 | 463 | [
"DDInter413",
"DDInter1590"
] | Clopidogrel | Rifampicin | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
1347,
24,
463
]
],
[
[
1347,
6,
7950
],
[
7950,
45,
463
]
],
[
[
1347,
24,
738
],
[
738,
63,
463
]
],
[
[
1347,
63,
305
],
[
305,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Clopidogrel (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rifampicin (Compound)
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin
Clopidogrel may ca... |
DB00010 | DB01261 | 1,649 | 170 | [
"DDInter1661",
"DDInter1679"
] | Sermorelin | Sitagliptin | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1649,
24,
170
]
],
[
[
1649,
24,
52
],
[
52,
62,
170
]
],
[
[
1649,
24,
1179
],
[
1179,
24,
170
]
],
[
[
1649,
24,
1254
],
[
1254,
... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
],
[
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and I... |
DB01149 | DB01211 | 851 | 609 | [
"DDInter1274",
"DDInter393"
] | Nefazodone | Clarithromycin | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
851,
24,
609
]
],
[
[
851,
6,
4973
],
[
4973,
45,
609
]
],
[
[
851,
21,
28662
],
[
28662,
60,
609
]
],
[
[
851,
63,
1601
],
[
1601,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Nefazodone (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Lora... |
DB00284 | DB09381 | 1,647 | 192 | [
"DDInter11",
"DDInter678"
] | Acarbose | Esterified estrogens | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1647,
24,
192
]
],
[
[
1647,
24,
1019
],
[
1019,
63,
192
]
],
[
[
1647,
24,
1040
],
[
1040,
24,
192
]
],
[
[
1647,
23,
1645
],
[
1645,... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
],
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib an... |
DB00321 | DB00782 | 21 | 1,123 | [
"DDInter78",
"DDInter1535"
] | Amitriptyline | Propantheline | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
21,
24,
1123
]
],
[
[
21,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
21,
18,
1954
],
[
1954,
57,
1123
]
],
[
[
21,
21,
28898
],
[
28898,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Comp... | Amitriptyline (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Amitriptyline (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Propantheline (Compound)
Amitriptyline (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propant... |
DB00902 | DB09128 | 104 | 1,241 | [
"DDInter1168",
"DDInter231"
] | Methdilazine | Brexpiprazole | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
104,
24,
1241
]
],
[
[
104,
24,
549
],
[
549,
24,
1241
]
],
[
[
104,
63,
1647
],
[
1647,
24,
1241
]
],
[
[
104,
24,
1296
],
[
1296,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose... |
DB00055 | DB09079 | 834 | 1,496 | [
"DDInter605",
"DDInter1296"
] | Drotrecogin alfa | Nintedanib | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Major | 2 | [
[
[
834,
25,
1496
]
],
[
[
834,
25,
707
],
[
707,
24,
1496
]
],
[
[
834,
64,
20
],
[
20,
24,
1496
]
],
[
[
834,
24,
765
],
[
765,
24... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nintedanib"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparoid",
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Drotrecogin alfa may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause... |
DB00662 | DB14575 | 717 | 733 | [
"DDInter1873",
"DDInter674"
] | Trimethobenzamide | Eslicarbazepine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
717,
24,
733
]
],
[
[
717,
24,
1264
],
[
1264,
24,
733
]
],
[
[
717,
63,
1614
],
[
1614,
24,
733
]
],
[
[
717,
24,
1264
],
[
1264,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Nabilone... |
DB00184 | DB00927 | 763 | 1,559 | [
"DDInter1290",
"DDInter712"
] | Nicotine | Famotidine | Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Minor | 0 | [
[
[
763,
23,
1559
]
],
[
[
763,
6,
10215
],
[
10215,
45,
1559
]
],
[
[
763,
18,
10375
],
[
10375,
57,
1559
]
],
[
[
763,
21,
29070
],
[
29... | [
[
[
"Nicotine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Famotidine"
]
],
[
[
"Nicotine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Nicotine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Famotidine (Compound)
Nicotine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Famotidine (Compound)
Nicotine (Compound) causes Sneezing (Side Effect) and Sneezing (Side Effect) is caused by Famotidine (Compound)
Nicoti... |
DB00377 | DB08864 | 1,494 | 786 | [
"DDInter1382",
"DDInter1595"
] | Palonosetron | Rilpivirine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
1494,
24,
786
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
786
]
],
[
[
1494,
21,
28734
],
[
28734,
60,
786
]
],
[
[
1494,
23,
112
],
[
112,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Palonosetron (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Rilpivirine (Compound)
Palonosetron may cause a minor interaction that can limit clinical effects whe... |
DB01208 | DB06335 | 945 | 761 | [
"DDInter1705",
"DDInter1646"
] | Sparfloxacin | Saxagliptin | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
945,
24,
761
]
],
[
[
945,
21,
29226
],
[
29226,
60,
761
]
],
[
[
945,
25,
1491
],
[
1491,
63,
761
]
],
[
[
945,
64,
1573
],
[
1573,
... | [
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Sinusitis"
],
[
"Sinusitis",
"{u} (Side Effect) is... | Sparfloxacin (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Saxagliptin (Compound)
Sparfloxacin may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Spa... |
DB00477 | DB06691 | 216 | 849 | [
"DDInter363",
"DDInter1155"
] | Chlorpromazine | Mepyramine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
216,
24,
849
]
],
[
[
216,
1,
11775
],
[
11775,
40,
849
]
],
[
[
216,
63,
1594
],
[
1594,
24,
849
]
],
[
[
216,
35,
272
],
[
272,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) resembles {v} (Compound)",
"Chloropyramine"
],
[
"Chloropyramine",
"{u} (Co... | Chlorpromazine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00758 | DB01039 | 1,347 | 535 | [
"DDInter413",
"DDInter718"
] | Clopidogrel | Fenofibrate | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Moderate | 1 | [
[
[
1347,
24,
535
]
],
[
[
1347,
63,
831
],
[
831,
1,
535
]
],
[
[
1347,
5,
11576
],
[
11576,
44,
535
]
],
[
[
1347,
6,
3486
],
[
3486,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibrate"
]
],
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indomethacin"
],
... | Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Fenofibrate (Compound)
Clopidogrel (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Fenofibrate (Compound)
Clopidogrel (Co... |
DB06779 | DB08875 | 365 | 1,618 | [
"DDInter470",
"DDInter262"
] | Dalteparin | Cabozantinib | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
365,
25,
1618
]
],
[
[
365,
24,
41
],
[
41,
63,
1618
]
],
[
[
365,
25,
283
],
[
283,
63,
1618
]
],
[
[
365,
63,
222
],
[
222,
24... | [
[
[
"Dalteparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Dalteparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"Lev... | Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Dalteparin may lead to a major life threatening interaction when taken with Fedratinib and Fedratini... |
DB00184 | DB12015 | 763 | 1,033 | [
"DDInter1290",
"DDInter53"
] | Nicotine | Alpelisib | Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
763,
24,
1033
]
],
[
[
763,
24,
593
],
[
593,
24,
1033
]
],
[
[
763,
23,
752
],
[
752,
23,
1135
],
[
1135,
23,
1033
]
],
[
[
763,
... | [
[
[
"Nicotine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Nicotine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
],
[
"B... | Nicotine may cause a moderate interaction that could exacerbate diseases when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Nicotine may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may ... |
DB06404 | DB08894 | 1,514 | 1,126 | [
"DDInter869",
"DDInter1406"
] | Human C1-esterase inhibitor | Peginesatide | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of th... | Moderate | 1 | [
[
[
1514,
24,
1126
]
],
[
[
1514,
25,
350
],
[
350,
25,
1126
]
],
[
[
1514,
64,
770
],
[
770,
25,
1126
]
],
[
[
1514,
25,
350
],
[
350,
... | [
[
[
"Human C1-esterase inhibitor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginesatide"
]
],
[
[
"Human C1-esterase inhibitor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfil... | Human C1-esterase inhibitor may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Peginesatide
Human C1-esterase inhibitor may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide ... |
DB00443 | DB01156 | 251 | 593 | [
"DDInter195",
"DDInter252"
] | Betamethasone | Bupropion | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
251,
25,
593
]
],
[
[
251,
6,
8374
],
[
8374,
45,
593
]
],
[
[
251,
18,
3677
],
[
3677,
46,
593
]
],
[
[
251,
7,
7710
],
[
7710,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bu... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Betamethasone (Compound) downregulates NFKBIE (Gene) and NFKBIE (Gene) is upregulated by Bupropion (Compound)
Betamethasone (Compound) upregulates ABCF3 (Gene) and ABCF3 (Gene) is downregulated by Bupropion (Compound)
Betame... |
DB00197 | DB11921 | 1,324 | 1,019 | [
"DDInter1881",
"DDInter492"
] | Troglitazone | Deflazacort | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1324,
24,
1019
]
],
[
[
1324,
24,
1072
],
[
1072,
23,
1019
]
],
[
[
1324,
24,
192
],
[
192,
24,
1019
]
],
[
[
1324,
24,
1619
],
[
1619... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens... |
DB00361 | DB01320 | 134 | 651 | [
"DDInter1939",
"DDInter783"
] | Vinorelbine | Fosphenytoin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
134,
24,
651
]
],
[
[
134,
23,
307
],
[
307,
1,
651
]
],
[
[
134,
63,
362
],
[
362,
1,
651
]
],
[
[
134,
6,
8374
],
[
8374,
45,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Vinorelbine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
... |
DB00515 | DB10315 | 589 | 1,137 | [
"DDInter387",
"DDInter1127"
] | Cisplatin | Measles virus vaccine live attenuated | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
589,
25,
1137
]
],
[
[
589,
24,
1042
],
[
1042,
24,
1137
]
],
[
[
589,
64,
581
],
[
581,
25,
1137
]
],
[
[
589,
63,
1184
],
[
1184,
... | [
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Cisplatin may lead to a major life threatening interaction when taken with Inf... |
DB09030 | DB15035 | 840 | 503 | [
"DDInter1945",
"DDInter1959"
] | Vorapaxar | Zanubrutinib | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
840,
25,
503
]
],
[
[
840,
63,
222
],
[
222,
24,
503
]
],
[
[
840,
24,
98
],
[
98,
24,
503
]
],
[
[
840,
64,
39
],
[
39,
25,
... | [
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatr... |
DB00470 | DB00835 | 530 | 100 | [
"DDInter601",
"DDInter245"
] | Dronabinol | Brompheniramine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
530,
24,
100
]
],
[
[
530,
24,
832
],
[
832,
24,
100
]
],
[
[
530,
63,
508
],
[
508,
24,
100
]
],
[
[
530,
24,
649
],
[
649,
63,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Promazin... |
DB00357 | DB08867 | 1,051 | 807 | [
"DDInter71",
"DDInter1897"
] | Aminoglutethimide | Ulipristal | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Moderate | 1 | [
[
[
1051,
24,
807
]
],
[
[
1051,
24,
1135
],
[
1135,
62,
807
]
],
[
[
1051,
24,
723
],
[
723,
23,
807
]
],
[
[
1051,
24,
792
],
[
792,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant ... |
DB00701 | DB12500 | 1,091 | 283 | [
"DDInter90",
"DDInter714"
] | Amprenavir | Fedratinib | Amprenavir is a protease inhibitor used to treat HIV infection. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1091,
25,
283
]
],
[
[
1091,
23,
466
],
[
466,
62,
283
]
],
[
[
1091,
25,
351
],
[
351,
23,
283
]
],
[
[
1091,
63,
1419
],
[
1419,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Amprenavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
"Darolutami... | Amprenavir may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Amprenavir may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause ... |
DB01181 | DB10315 | 1,532 | 1,137 | [
"DDInter906",
"DDInter1127"
] | Ifosfamide | Measles virus vaccine live attenuated | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1532,
25,
1137
]
],
[
[
1532,
64,
581
],
[
581,
25,
1137
]
],
[
[
1532,
63,
1184
],
[
1184,
25,
1137
]
],
[
[
1532,
24,
37
],
[
37,
... | [
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Ifosfamide may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra ma... |
DB00294 | DB01098 | 1,336 | 14 | [
"DDInter701",
"DDInter1622"
] | Etonogestrel | Rosuvastatin | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Minor | 0 | [
[
[
1336,
23,
14
]
],
[
[
1336,
6,
8374
],
[
8374,
45,
14
]
],
[
[
1336,
21,
29579
],
[
29579,
60,
14
]
],
[
[
1336,
40,
1657
],
[
1657,
... | [
[
[
"Etonogestrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Etonogestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Etonogestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rosuvastatin (Compound)
Etonogestrel (Compound) causes Breast disorder (Side Effect) and Breast disorder (Side Effect) is caused by Rosuvastatin (Compound)
Etonogestrel (Compound) resembles Desogestrel (Compound) and Desogestrel may cause a minor... |
DB00264 | DB06292 | 88 | 549 | [
"DDInter1200",
"DDInter474"
] | Metoprolol | Dapagliflozin | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
88,
24,
549
]
],
[
[
88,
24,
1344
],
[
1344,
40,
549
]
],
[
[
88,
6,
12523
],
[
12523,
45,
549
]
],
[
[
88,
21,
29222
],
[
29222,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Metoprolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dapagliflozin (Compound)
Metoprolol (Compound) causes Hypoglycaemia (Side Effec... |
DB00382 | DB00916 | 62 | 112 | [
"DDInter1734",
"DDInter1202"
] | Tacrine | Metronidazole | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
62,
24,
112
]
],
[
[
62,
24,
51
],
[
51,
23,
112
]
],
[
[
62,
24,
1616
],
[
1616,
62,
112
]
],
[
[
62,
63,
702
],
[
702,
23,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and Histreli... |
DB00046 | DB00738 | 1,179 | 485 | [
"DDInter940",
"DDInter1420"
] | Insulin lispro | Pentamidine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
1179,
24,
485
]
],
[
[
1179,
24,
1247
],
[
1247,
62,
485
]
],
[
[
1179,
24,
1450
],
[
1450,
63,
485
]
],
[
[
1179,
25,
739
],
[
739,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pentamidine
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Em... |
DB00631 | DB06589 | 372 | 1,250 | [
"DDInter405",
"DDInter1400"
] | Clofarabine | Pazopanib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
372,
24,
1250
]
],
[
[
372,
6,
17404
],
[
17404,
45,
1250
]
],
[
[
372,
7,
20113
],
[
20113,
46,
1250
]
],
[
[
372,
18,
5580
],
[
5580... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Clofarabine",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Pazopanib (Compound)
Clofarabine (Compound) upregulates IER3 (Gene) and IER3 (Gene) is upregulated by Pazopanib (Compound)
Clofarabine (Compound) downregulates NUP93 (Gene) and NUP93 (Gene) is upregulated by Pazopanib (Compound)
Clofarabine (Compoun... |
DB00012 | DB00790 | 1,535 | 664 | [
"DDInter479",
"DDInter1431"
] | Darbepoetin alfa | Perindopril | Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Minor | 0 | [
[
[
1535,
23,
664
]
],
[
[
1535,
23,
1638
],
[
1638,
1,
664
]
],
[
[
1535,
23,
954
],
[
954,
40,
664
]
],
[
[
1535,
23,
1638
],
[
1638,
... | [
[
[
"Darbepoetin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Perindopril"
]
],
[
[
"Darbepoetin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trandolapril"
... | Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Quinapril and Quinapril (Compound) resembles Perindopril... |
DB01138 | DB06335 | 804 | 761 | [
"DDInter1726",
"DDInter1646"
] | Sulfinpyrazone | Saxagliptin | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
804,
24,
761
]
],
[
[
804,
6,
10417
],
[
10417,
45,
761
]
],
[
[
804,
24,
1491
],
[
1491,
63,
761
]
],
[
[
804,
24,
478
],
[
478,
... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Sulfinpyrazone",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Comp... | Sulfinpyrazone (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saxagliptin (Compound)
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Sulfinpy... |
DB00491 | DB01284 | 127 | 1,042 | [
"DDInter1217",
"DDInter1782"
] | Miglitol | Tetracosactide | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
127,
24,
1042
]
],
[
[
127,
24,
480
],
[
480,
23,
1042
]
],
[
[
127,
24,
659
],
[
659,
62,
1042
]
],
[
[
127,
24,
811
],
[
811,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanter... |
DB00476 | DB11186 | 109 | 1,609 | [
"DDInter608",
"DDInter1427"
] | Duloxetine | Pentoxyverine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
109,
24,
1609
]
],
[
[
109,
40,
758
],
[
758,
24,
1609
]
],
[
[
109,
24,
104
],
[
104,
24,
1609
]
],
[
[
109,
63,
999
],
[
999,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Duloxetine",
"{u} (Compound) resembles {v} (Compound)",
"Fluoxetine"
],
[
"Fluoxetine",
"{u} may cause a mode... | Duloxetine (Compound) resembles Fluoxetine (Compound) and Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction tha... |
DB00635 | DB00728 | 1,573 | 1,610 | [
"DDInter1515",
"DDInter1612"
] | Prednisone | Rocuronium | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechan... | Moderate | 1 | [
[
[
1573,
24,
1610
]
],
[
[
1573,
24,
728
],
[
728,
40,
1610
]
],
[
[
1573,
6,
6648
],
[
6648,
45,
1610
]
],
[
[
1573,
21,
28778
],
[
2877... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vecuronium"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Vecuronium and Vecuronium (Compound) resembles Rocuronium (Compound)
Prednisone (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Rocuronium (Compound)
Prednisone (Compound) causes Anaphylactic shock (Side Effect) an... |
DB00530 | DB01045 | 1,195 | 463 | [
"DDInter667",
"DDInter1590"
] | Erlotinib | Rifampicin | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
1195,
24,
463
]
],
[
[
1195,
24,
690
],
[
690,
40,
463
]
],
[
[
1195,
6,
7950
],
[
7950,
45,
463
]
],
[
[
1195,
63,
1101
],
[
1101,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Erlotinib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rifampicin (Compound)
Erlotinib may cause a moderate interaction that could exacerbate disea... |
DB00903 | DB11110 | 1,680 | 603 | [
"DDInter686",
"DDInter1115"
] | Etacrynic acid | Magnesium citrate | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1680,
24,
603
]
],
[
[
1680,
25,
57
],
[
57,
24,
603
]
],
[
[
1680,
63,
870
],
[
870,
24,
603
]
],
[
[
1680,
64,
1425
],
[
1425,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Etacrynic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
... | Etacrynic acid may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Fludrocor... |
DB00682 | DB04932 | 126 | 1,564 | [
"DDInter1951",
"DDInter491"
] | Warfarin | Defibrotide | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Major | 2 | [
[
[
126,
25,
1564
]
],
[
[
126,
23,
297
],
[
297,
62,
1564
]
],
[
[
126,
25,
914
],
[
914,
24,
1564
]
],
[
[
126,
24,
1039
],
[
1039,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} m... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Warfarin may lead to a major life threatening interaction when taken with Diflunisal and Diflunisal may cause a moderate intera... |
DB06186 | DB11095 | 1,439 | 235 | [
"DDInter969",
"DDInter505"
] | Ipilimumab | Desirudin | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
1439,
25,
235
]
],
[
[
1439,
25,
1409
],
[
1409,
25,
235
]
],
[
[
1439,
63,
175
],
[
175,
25,
235
]
],
[
[
1439,
25,
1421
],
[
1421,
... | [
[
[
"Ipilimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Ipilimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[
"Apixaban",
"{u} may le... | Ipilimumab may lead to a major life threatening interaction when taken with Apixaban and Apixaban may lead to a major life threatening interaction when taken with Desirudin
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may lead to a major life... |
DB01067 | DB04861 | 959 | 1,592 | [
"DDInter826",
"DDInter1271"
] | Glipizide | Nebivolol | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
959,
24,
1592
]
],
[
[
959,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
959,
24,
1283
],
[
1283,
23,
1592
]
],
[
[
959,
63,
1479
],
[
1479... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Glipizide",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by... | Glipizide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Nebi... |
DB00783 | DB12130 | 1,438 | 1,017 | [
"DDInter679",
"DDInter1094"
] | Estradiol | Lorlatinib | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1438,
24,
1017
]
],
[
[
1438,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
1438,
63,
590
],
[
590,
24,
1017
]
],
[
[
1438,
24,
549
],
[
549,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohe... |
DB00467 | DB01156 | 1,467 | 593 | [
"DDInter644",
"DDInter252"
] | Enoxacin | Bupropion | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1467,
25,
593
]
],
[
[
1467,
6,
7950
],
[
7950,
45,
593
]
],
[
[
1467,
18,
4930
],
[
4930,
57,
593
]
],
[
[
1467,
23,
752
],
[
752,
... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Enoxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Bupropion"
... | Enoxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Bupropion (Compound)
Enoxacin (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Bupropion (Compound)
Enoxacin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a min... |
DB00334 | DB06589 | 867 | 1,250 | [
"DDInter1326",
"DDInter1400"
] | Olanzapine | Pazopanib | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
867,
24,
1250
]
],
[
[
867,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
867,
7,
4759
],
[
4759,
46,
1250
]
],
[
[
867,
23,
112
],
[
112,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Olanzapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Olanzapine (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Pazopanib (Compound)
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazo... |
DB00365 | DB06792 | 839 | 1,606 | [
"DDInter842",
"DDInter1023"
] | Grepafloxacin | Lanthanum carbonate | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
839,
24,
1606
]
],
[
[
839,
25,
1487
],
[
1487,
24,
1606
]
],
[
[
839,
24,
428
],
[
428,
63,
1606
]
],
[
[
839,
24,
1096
],
[
1096,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
... | Grepafloxacin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ferro... |
DB04948 | DB11186 | 1,084 | 1,609 | [
"DDInter1083",
"DDInter1427"
] | Lofexidine | Pentoxyverine | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1084,
24,
1609
]
],
[
[
1084,
63,
104
],
[
104,
24,
1609
]
],
[
[
1084,
24,
849
],
[
849,
24,
1609
]
],
[
[
1084,
40,
1020
],
[
1020,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and... |
DB00916 | DB09570 | 112 | 1,480 | [
"DDInter1202",
"DDInter1002"
] | Metronidazole | Ixazomib | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
112,
24,
1480
]
],
[
[
112,
63,
268
],
[
268,
24,
1480
]
],
[
[
112,
24,
148
],
[
148,
63,
1480
]
],
[
[
112,
24,
310
],
[
310,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00358 | DB12267 | 1,010 | 1,476 | [
"DDInter1140",
"DDInter233"
] | Mefloquine | Brigatinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1010,
24,
1476
]
],
[
[
1010,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
1010,
24,
629
],
[
629,
24,
1476
]
],
[
[
1010,
24,
1598
],
[
1598... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolim... |
DB01591 | DB06788 | 667 | 1,616 | [
"DDInter1696",
"DDInter864"
] | Solifenacin | Histrelin | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
667,
24,
1616
]
],
[
[
667,
62,
112
],
[
112,
23,
1616
]
],
[
[
667,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
667,
63,
77
],
[
77,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Solifenacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Solifenacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Rom... |
DB00005 | DB00603 | 1,057 | 303 | [
"DDInter687",
"DDInter1137"
] | Etanercept | Medroxyprogesterone acetate | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Moderate | 1 | [
[
[
1057,
24,
303
]
],
[
[
1057,
25,
167
],
[
167,
1,
303
]
],
[
[
1057,
24,
700
],
[
700,
62,
303
]
],
[
[
1057,
25,
305
],
[
305,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone acetate"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
],
... | Etanercept may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Medroxyprogesterone acetate (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin may cause a minor interaction... |
DB00014 | DB09080 | 521 | 144 | [
"DDInter839",
"DDInter1331"
] | Goserelin | Olodaterol | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
521,
24,
144
]
],
[
[
521,
23,
1247
],
[
1247,
23,
144
]
],
[
[
521,
24,
956
],
[
956,
24,
144
]
],
[
[
521,
25,
1011
],
[
1011,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and... |
DB00620 | DB01162 | 175 | 195 | [
"DDInter1855",
"DDInter1767"
] | Triamcinolone | Terazosin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Moderate | 1 | [
[
[
175,
24,
195
]
],
[
[
175,
63,
1205
],
[
1205,
40,
195
]
],
[
[
175,
21,
28882
],
[
28882,
60,
195
]
],
[
[
175,
40,
870
],
[
870,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
],
[... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Terazosin (Compound)
Triamcinolone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Terazosin (Compound)
Triamcinol... |
DB00405 | DB14740 | 128 | 771 | [
"DDInter517",
"DDInter881"
] | Dexbrompheniramine | Hyaluronidase | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
128,
23,
771
]
],
[
[
128,
24,
849
],
[
849,
23,
771
]
],
[
[
128,
63,
1242
],
[
1242,
23,
771
]
],
[
[
128,
24,
849
],
[
849,
2... | [
[
[
"Dexbrompheniramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ceti... |
DB06605 | DB11560 | 1,409 | 1,678 | [
"DDInter108",
"DDInter1038"
] | Apixaban | Lesinurad | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
1409,
24,
1678
]
],
[
[
1409,
63,
1374
],
[
1374,
24,
1678
]
],
[
[
1409,
25,
913
],
[
913,
63,
1678
]
],
[
[
1409,
64,
1479
],
[
1479... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad
Apixaban may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a... |
DB00280 | DB09036 | 494 | 812 | [
"DDInter575",
"DDInter1668"
] | Disopyramide | Siltuximab | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
494,
24,
812
]
],
[
[
494,
63,
1031
],
[
1031,
24,
812
]
],
[
[
494,
24,
608
],
[
608,
24,
812
]
],
[
[
494,
23,
126
],
[
126,
2... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and... |
DB09073 | DB09330 | 951 | 985 | [
"DDInter1379",
"DDInter1352"
] | Palbociclib | Osimertinib | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
951,
24,
985
]
],
[
[
951,
63,
1478
],
[
1478,
24,
985
]
],
[
[
951,
24,
1598
],
[
1598,
63,
985
]
],
[
[
951,
24,
1580
],
[
1580,
... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Taz... |
DB00618 | DB13909 | 1,572 | 1,277 | [
"DDInter498",
"DDInter214"
] | Demeclocycline | Bismuth subgallate | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet... | Moderate | 1 | [
[
[
1572,
24,
1277
]
],
[
[
1572,
40,
964
],
[
964,
24,
1277
]
],
[
[
1572,
1,
1669
],
[
1669,
24,
1277
]
],
[
[
1572,
40,
964
],
[
964,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bismuth subgallate"
]
],
[
[
"Demeclocycline",
"{u} (Compound) resembles {v} (Compound)",
"Doxycycline"
],
[
"Doxycycline",
"{u} m... | Demeclocycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Bismuth subgallate
Demeclocycline (Compound) resembles Minocycline (Compound) and Minocycline may cause a moderate interaction that could exacerbate diseases when ta... |
DB00818 | DB01218 | 898 | 1,493 | [
"DDInter1538",
"DDInter852"
] | Propofol | Halofantrine | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Moderate | 1 | [
[
[
898,
24,
1493
]
],
[
[
898,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
898,
21,
28763
],
[
28763,
60,
1493
]
],
[
[
898,
23,
112
],
[
112,
... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halofantrine"
]
],
[
[
"Propofol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Propofol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Propofol (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Halofantrine (Compound)
Propofol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
DB00289 | DB06589 | 847 | 1,250 | [
"DDInter132",
"DDInter1400"
] | Atomoxetine | Pazopanib | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
847,
24,
1250
]
],
[
[
847,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
847,
21,
29264
],
[
29264,
60,
1250
]
],
[
[
847,
40,
307
],
[
307,... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Atomoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Atomoxetine (Compound) causes Rhinorrhoea (Side Effect) and Rhinorrhoea (Side Effect) is caused by Pazopanib (Compound)
Atomoxetine (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can... |
DB00927 | DB01224 | 1,559 | 623 | [
"DDInter712",
"DDInter1553"
] | Famotidine | Quetiapine | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1559,
24,
623
]
],
[
[
1559,
63,
827
],
[
827,
1,
623
]
],
[
[
1559,
6,
10215
],
[
10215,
45,
623
]
],
[
[
1559,
18,
7359
],
[
7359,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Famotidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Quetiapine (Compound)
Famotidine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene... |
DB00196 | DB05528 | 600 | 1,070 | [
"DDInter743",
"DDInter1228"
] | Fluconazole | Mipomersen | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
600,
25,
1070
]
],
[
[
600,
24,
1512
],
[
1512,
25,
1070
]
],
[
[
600,
24,
1250
],
[
1250,
64,
1070
]
],
[
[
600,
23,
14
],
[
14,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
"Diclofen... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lead to a major life threatening interaction when taken with Mipomersen
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazopanib may lead t... |
DB09237 | DB11093 | 1,586 | 636 | [
"DDInter1045",
"DDInter273"
] | Levamlodipine | Calcium citrate | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1586,
24,
636
]
],
[
[
1586,
62,
578
],
[
578,
62,
819
],
[
819,
24,
636
]
],
[
[
1586,
63,
1479
],
[
1479,
23,
819
],
[
819,
24,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Levamlodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
],... | Levamlodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Le... |
DB00531 | DB00682 | 450 | 126 | [
"DDInter456",
"DDInter1951"
] | Cyclophosphamide | Warfarin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
450,
24,
126
]
],
[
[
450,
24,
1335
],
[
1335,
40,
126
]
],
[
[
450,
63,
362
],
[
362,
24,
126
]
],
[
[
450,
6,
3486
],
[
3486,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Warfarin (Compound)
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interact... |
DB05812 | DB08871 | 1,374 | 36 | [
"DDInter8",
"DDInter666"
] | Abiraterone | Eribulin | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1374,
24,
36
]
],
[
[
1374,
62,
1247
],
[
1247,
23,
36
]
],
[
[
1374,
63,
519
],
[
519,
24,
36
]
],
[
[
1374,
62,
479
],
[
479,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone ... |
DB00339 | DB08870 | 1,182 | 850 | [
"DDInter1547",
"DDInter228"
] | Pyrazinamide | Brentuximab vedotin | A pyrazine that is used therapeutically as an antitubercular agent. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1182,
24,
850
]
],
[
[
1182,
24,
267
],
[
267,
24,
850
]
],
[
[
1182,
63,
305
],
[
305,
24,
850
]
],
[
[
1182,
24,
384
],
[
384,
... | [
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with Asparagi... |
DB00363 | DB11760 | 695 | 119 | [
"DDInter419",
"DDInter1742"
] | Clozapine | Talazoparib | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Major | 2 | [
[
[
695,
25,
119
]
],
[
[
695,
64,
599
],
[
599,
24,
119
]
],
[
[
695,
25,
985
],
[
985,
24,
119
]
],
[
[
695,
24,
1670
],
[
1670,
2... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Talazoparib"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alemtuzumab"
],
[
"Alemtuzumab",
"{u} ... | Clozapine may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Clozapine may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate i... |
DB00374 | DB00421 | 1,061 | 443 | [
"DDInter1852",
"DDInter1707"
] | Treprostinil | Spironolactone | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Moderate | 1 | [
[
[
1061,
24,
443
]
],
[
[
1061,
24,
312
],
[
312,
40,
443
]
],
[
[
1061,
7,
7483
],
[
7483,
46,
443
]
],
[
[
1061,
18,
7744
],
[
7744,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone (Compound) resembles Spironolactone (Compound)
Treprostinil (Compound) upregulates HLA-DMA (Gene) and HLA-DMA (Gene) is upregulated by Spironolactone (Compound)
Treprostinil (Compound) downregulates PR... |
DB00585 | DB09481 | 1,127 | 460 | [
"DDInter1309",
"DDInter1113"
] | Nizatidine | Magnesium carbonate | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1127,
23,
460
]
],
[
[
1127,
62,
109
],
[
109,
23,
460
]
],
[
[
1127,
23,
1468
],
[
1468,
23,
460
]
],
[
[
1127,
1,
1194
],
[
1194,
... | [
[
[
"Nizatidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Nizatidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Duloxetine"
],
... | Nizatidine may cause a minor interaction that can limit clinical effects when taken with Duloxetine and Duloxetine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Nizatidine may cause a minor interaction that can limit clinical effects when taken with Ponatinib and Pona... |
DB01155 | DB01218 | 872 | 1,493 | [
"DDInter813",
"DDInter852"
] | Gemifloxacin | Halofantrine | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
872,
25,
1493
]
],
[
[
872,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
872,
62,
112
],
[
112,
23,
1493
]
],
[
[
872,
63,
770
],
[
770,
... | [
[
[
"Gemifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{u} (Side ... | Gemifloxacin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical... |
DB00480 | DB10989 | 1,668 | 496 | [
"DDInter1035",
"DDInter858"
] | Lenalidomide | Hepatitis A Vaccine | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1668,
24,
496
]
],
[
[
1668,
24,
4
],
[
4,
24,
496
]
],
[
[
1668,
24,
738
],
[
738,
63,
496
]
],
[
[
1668,
25,
976
],
[
976,
24,... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine me... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Lenalidomide may cause a moderate interaction that could exacerbate dis... |
DB09065 | DB09083 | 760 | 880 | [
"DDInter424",
"DDInter996"
] | Cobicistat | Ivabradine | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
760,
25,
880
]
],
[
[
760,
64,
1478
],
[
1478,
24,
880
]
],
[
[
760,
25,
159
],
[
159,
63,
880
]
],
[
[
760,
63,
1040
],
[
1040,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
"{u} may... | Cobicistat may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Cobicistat may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a moderate ... |
DB00321 | DB00835 | 21 | 100 | [
"DDInter78",
"DDInter245"
] | Amitriptyline | Brompheniramine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
21,
24,
100
]
],
[
[
21,
35,
832
],
[
832,
24,
100
]
],
[
[
21,
1,
508
],
[
508,
24,
100
]
],
[
[
21,
24,
128
],
[
128,
24,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases w... | Amitriptyline (Compound) resembles Tripelennamine (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Amitriptyline (Compound) resemb... |
DB00307 | DB00460 | 1,101 | 612 | [
"DDInter203",
"DDInter1929"
] | Bexarotene (topical) | Verteporfin | Bexarotene is a retinoid, a member of benzoic acids and a member of naphthalenes. It has a role as an antineoplastic agent. | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
1101,
24,
612
]
],
[
[
1101,
21,
29044
],
[
29044,
60,
612
]
],
[
[
1101,
24,
392
],
[
392,
63,
612
]
],
[
[
1101,
23,
1419
],
[
1419,... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Bexarotene",
"{u} (Compound) causes {v} (Side Effect)",
"Pneumonia"
],
[
"Pneumonia",
"{u} (Side Effect) is cau... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin
Bexarotene (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Verteporfin (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib... |
DB00159 | DB01166 | 940 | 477 | [
"DDInter903",
"DDInter379"
] | Icosapent | Cilostazol | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
940,
24,
477
]
],
[
[
940,
21,
28658
],
[
28658,
60,
477
]
],
[
[
940,
24,
126
],
[
126,
23,
477
]
],
[
[
940,
24,
936
],
[
936,
... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Icosapent",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused b... | Icosapent (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cilostazol (Compound)
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Icosap... |
DB00719 | DB00985 | 1,219 | 1,443 | [
"DDInter149",
"DDInter562"
] | Azatadine | Dimenhydrinate | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Moderate | 1 | [
[
[
1219,
24,
1443
]
],
[
[
1219,
24,
1376
],
[
1376,
63,
1443
]
],
[
[
1219,
63,
357
],
[
357,
1,
1443
]
],
[
[
1219,
24,
358
],
[
358,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimenhydrinate"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dimenhydrinate
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Benzatrop... |
DB00245 | DB00366 | 357 | 1,594 | [
"DDInter181",
"DDInter600"
] | Benzatropine | Doxylamine | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
357,
24,
1594
]
],
[
[
357,
24,
662
],
[
662,
63,
1594
]
],
[
[
357,
40,
847
],
[
847,
1,
1594
]
],
[
[
357,
1,
939
],
[
939,
1,... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Benzatropine (Compound) resembles Atomoxetine (Compound) and Atomoxetine (Compound) resembles Doxylamine... |
DB00398 | DB00862 | 79 | 1,005 | [
"DDInter1702",
"DDInter1918"
] | Sorafenib | Vardenafil | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Moderate | 1 | [
[
[
79,
24,
1005
]
],
[
[
79,
6,
8374
],
[
8374,
45,
1005
]
],
[
[
79,
21,
28658
],
[
28658,
60,
1005
]
],
[
[
79,
23,
112
],
[
112,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vardenafil"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Sorafenib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vardenafil (Compound)
Sorafenib (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Vardenafil (Compound)
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronid... |
DB00836 | DB06448 | 543 | 171 | [
"DDInter1088",
"DDInter1087"
] | Loperamide | Lonafarnib | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
543,
25,
171
]
],
[
[
543,
63,
888
],
[
888,
24,
171
]
],
[
[
543,
24,
112
],
[
112,
24,
171
]
],
[
[
543,
64,
1347
],
[
1347,
2... | [
[
[
"Loperamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metro... |
DB12332 | DB14711 | 1,619 | 779 | [
"DDInter1626",
"DDInter1680"
] | Rucaparib | Smallpox (Vaccinia) Vaccine, Live | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
1619,
25,
779
]
],
[
[
1619,
64,
1064
],
[
1064,
25,
779
]
],
[
[
1619,
63,
147
],
[
147,
25,
779
]
],
[
[
1619,
25,
676
],
[
676,
... | [
[
[
"Rucaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Rucaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Clad... | Rucaparib may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine ma... |
DB06764 | DB09080 | 1,090 | 144 | [
"DDInter1788",
"DDInter1331"
] | Tetryzoline (ophthalmic) | Olodaterol | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1090,
24,
144
]
],
[
[
1090,
63,
1290
],
[
1290,
24,
144
]
],
[
[
1090,
24,
1663
],
[
1663,
63,
144
]
],
[
[
1090,
24,
41
],
[
41,
... | [
[
[
"Tetryzoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Tetryzoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midodrine"
],
[
... | Tetryzoline may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Tetryzoline may cause a moderate interaction that could exacerbate diseases when taken with Midodrine and Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Tetryzolin... |
DB09134 | DB14761 | 1,552 | 242 | [
"DDInter966",
"DDInter1578"
] | Ioversol | Remdesivir | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1552,
24,
242
]
],
[
[
1552,
64,
1512
],
[
1512,
24,
242
]
],
[
[
1552,
63,
1648
],
[
1648,
24,
242
]
],
[
[
1552,
64,
1512
],
[
1512,... | [
[
[
"Ioversol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Ioversol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
],
[
"Diclofenac",
... | Ioversol may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Ioversol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a ... |
DB00627 | DB06292 | 265 | 549 | [
"DDInter1286",
"DDInter474"
] | Niacin | Dapagliflozin | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
265,
24,
549
]
],
[
[
265,
24,
1344
],
[
1344,
40,
549
]
],
[
[
265,
6,
12523
],
[
12523,
45,
549
]
],
[
[
265,
21,
28882
],
[
28882,
... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Niacin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dapagliflozin (Compound)
Niacin (Compound) causes Body temperature increased (Side Effe... |
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