drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01036 | DB06603 | 211 | 39 | [
"DDInter1832",
"DDInter1387"
] | Tolterodine | Panobinostat | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Minor | 0 | [
[
[
211,
23,
39
]
],
[
[
211,
35,
272
],
[
272,
24,
39
]
],
[
[
211,
24,
1478
],
[
1478,
63,
39
]
],
[
[
211,
63,
1419
],
[
1419,
24... | [
[
[
"Tolterodine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Panobinostat"
]
],
[
[
"Tolterodine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken... | Tolterodine (Compound) resembles Chlorpheniramine (Compound) and Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Tolterodine may cause a moderate... |
DB00572 | DB01102 | 85 | 1,188 | [
"DDInter136",
"DDInter114"
] | Atropine | Arbutamine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately . | Moderate | 1 | [
[
[
85,
24,
1188
]
],
[
[
85,
24,
1523
],
[
1523,
40,
1188
]
],
[
[
85,
24,
1507
],
[
1507,
24,
1188
]
],
[
[
85,
63,
19
],
[
19,
24... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arbutamine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
"... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Arbutamine (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exa... |
DB00346 | DB08865 | 472 | 1,593 | [
"DDInter44",
"DDInter448"
] | Alfuzosin | Crizotinib | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
472,
25,
1593
]
],
[
[
472,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
472,
7,
4759
],
[
4759,
46,
1593
]
],
[
[
472,
18,
2852
],
[
2852,
... | [
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotini... | Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Alfuzosin (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Crizotinib (Compound)
Alfuzosin (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Crizotinib (Compound)
Alfuzosin (... |
DB00404 | DB00662 | 523 | 717 | [
"DDInter54",
"DDInter1873"
] | Alprazolam | Trimethobenzamide | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
523,
24,
717
]
],
[
[
523,
7,
13042
],
[
13042,
46,
717
]
],
[
[
523,
21,
29648
],
[
29648,
60,
717
]
],
[
[
523,
40,
1382
],
[
1382,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Alprazolam",
"{u} (Compound) upregulates {v} (Gene)",
"HIST1H2BK"
],
[
"HIST1H2BK",
"{u} (Gene) is upregu... | Alprazolam (Compound) upregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Trimethobenzamide (Compound)
Alprazolam (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Alprazolam (Compound) resembles Midazolam (Compound) and Midazolam m... |
DB01128 | DB06016 | 918 | 1,508 | [
"DDInter204",
"DDInter300"
] | Bicalutamide | Cariprazine | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
918,
24,
1508
]
],
[
[
918,
25,
1593
],
[
1593,
63,
1508
]
],
[
[
918,
63,
600
],
[
600,
24,
1508
]
],
[
[
918,
24,
1213
],
[
1213,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizo... | Bicalutamide may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may... |
DB00480 | DB04575 | 1,668 | 35 | [
"DDInter1035",
"DDInter1555"
] | Lenalidomide | Quinestrol | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | The 3-cyclopentyl ether of ethinyl estradiol. | Major | 2 | [
[
[
1668,
25,
35
]
],
[
[
1668,
25,
890
],
[
890,
1,
35
]
],
[
[
1668,
25,
177
],
[
177,
40,
35
]
],
[
[
1668,
64,
380
],
[
380,
1,
... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinestrol"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mestranol"
],
[
"Mestranol",
"{u}... | Lenalidomide may lead to a major life threatening interaction when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Lenalidomide may lead to a major life threatening interaction when taken with Estrone sulfate and Estrone sulfate (Compound) resembles Quinestrol (Compound)
Lenalidomide may l... |
DB00245 | DB00662 | 357 | 717 | [
"DDInter181",
"DDInter1873"
] | Benzatropine | Trimethobenzamide | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
357,
24,
717
]
],
[
[
357,
21,
29648
],
[
29648,
60,
717
]
],
[
[
357,
24,
1594
],
[
1594,
24,
717
]
],
[
[
357,
24,
1376
],
[
1376,
... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Benzatropine",
"{u} (Compound) causes {v} (Side Effect)",
"Disorientation"
],
[
"Disorientation",
"{u} ... | Benzatropine (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases wh... |
DB01234 | DB04861 | 1,220 | 1,592 | [
"DDInter513",
"DDInter1271"
] | Dexamethasone | Nebivolol | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1220,
24,
1592
]
],
[
[
1220,
6,
12523
],
[
12523,
45,
1592
]
],
[
[
1220,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
1220,
23,
1283
],
[
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Dexamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compou... | Dexamethasone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nebivolol (Compound)
Dexamethasone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide ... |
DB01211 | DB06403 | 609 | 1,204 | [
"DDInter393",
"DDInter62"
] | Clarithromycin | Ambrisentan | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Minor | 0 | [
[
[
609,
23,
1204
]
],
[
[
609,
62,
600
],
[
600,
23,
1204
]
],
[
[
609,
24,
760
],
[
760,
62,
1204
]
],
[
[
609,
25,
868
],
[
868,
... | [
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ambrisentan"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fluconazole"
],
... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ambrisentan
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and... |
DB01069 | DB01377 | 401 | 1,283 | [
"DDInter1533",
"DDInter1119"
] | Promethazine | Magnesium oxide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
401,
23,
1283
]
],
[
[
401,
63,
743
],
[
743,
23,
1283
]
],
[
[
401,
75,
684
],
[
684,
23,
1283
]
],
[
[
401,
74,
216
],
[
216,
... | [
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Promethazine (Compound) resembles Thioridazine (Compound) and Promethazine may lead to a major life threate... |
DB01138 | DB01240 | 804 | 885 | [
"DDInter1726",
"DDInter657"
] | Sulfinpyrazone | Epoprostenol | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
804,
24,
885
]
],
[
[
804,
63,
1061
],
[
1061,
1,
885
]
],
[
[
804,
6,
6017
],
[
6017,
45,
885
]
],
[
[
804,
63,
1512
],
[
1512,
... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Sulfinpyrazone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Sulfinpyrazone may cause a moderate interaction th... |
DB00295 | DB11823 | 475 | 858 | [
"DDInter1244",
"DDInter673"
] | Morphine | Esketamine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
475,
24,
858
]
],
[
[
475,
24,
272
],
[
272,
24,
858
]
],
[
[
475,
63,
1648
],
[
1648,
24,
858
]
],
[
[
475,
25,
1629
],
[
1629,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin a... |
DB01390 | DB13257 | 1,117 | 260 | [
"DDInter1683",
"DDInter727"
] | Sodium bicarbonate | Ferrous sulfate anhydrous | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
1117,
24,
260
]
],
[
[
1117,
62,
752
],
[
752,
23,
260
]
],
[
[
1117,
63,
1096
],
[
1096,
23,
260
]
],
[
[
1117,
63,
1620
],
[
1620,
... | [
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
... | Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ferrous sulfate anhydrous
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken... |
DB00374 | DB06700 | 1,061 | 643 | [
"DDInter1852",
"DDInter511"
] | Treprostinil | Desvenlafaxine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
1061,
24,
643
]
],
[
[
1061,
63,
1100
],
[
1100,
1,
643
]
],
[
[
1061,
21,
28709
],
[
28709,
60,
643
]
],
[
[
1061,
25,
292
],
[
292,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Treprostinil (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Desvenlafaxine (Compound)
Treprostinil... |
DB01075 | DB01367 | 1,376 | 1,163 | [
"DDInter569",
"DDInter1572"
] | Diphenhydramine | Rasagiline | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1376,
24,
1163
]
],
[
[
1376,
6,
7950
],
[
7950,
45,
1163
]
],
[
[
1376,
10,
11558
],
[
11558,
49,
1163
]
],
[
[
1376,
21,
28714
],
[
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (C... | Diphenhydramine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rasagiline (Compound)
Diphenhydramine (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Rasagiline (Compound)
Diphenhydramine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect... |
DB00855 | DB01324 | 213 | 178 | [
"DDInter72",
"DDInter1490"
] | Aminolevulinic acid | Polythiazide | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Major | 2 | [
[
[
213,
25,
178
]
],
[
[
213,
25,
504
],
[
504,
40,
178
]
],
[
[
213,
64,
323
],
[
323,
40,
178
]
],
[
[
213,
21,
29232
],
[
29232,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polythiazide"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrochlorothiazide"
],
[
... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Aminolevulinic acid may lead to a major life threatening interaction when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) resemb... |
DB01172 | DB01330 | 416 | 1,402 | [
"DDInter1004",
"DDInter324"
] | Kanamycin | Cefotetan | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. | Moderate | 1 | [
[
[
416,
24,
1402
]
],
[
[
416,
24,
1124
],
[
1124,
1,
1402
]
],
[
[
416,
24,
1558
],
[
1558,
40,
1402
]
],
[
[
416,
63,
277
],
[
277,
... | [
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefotetan"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefamandole"
],
[
... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Cefamandole and Cefamandole (Compound) resembles Cefotetan (Compound)
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Cefoxitin and Cefoxitin (Compound) resembles Cefotetan (Compound)
Kana... |
DB01069 | DB09268 | 401 | 1,662 | [
"DDInter1533",
"DDInter1464"
] | Promethazine | Picosulfuric acid | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
401,
24,
1662
]
],
[
[
401,
74,
1164
],
[
1164,
24,
1662
]
],
[
[
401,
24,
484
],
[
484,
63,
1662
]
],
[
[
401,
24,
93
],
[
93,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Promethazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases w... | Promethazine (Compound) resembles Trimipramine (Compound) and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Promethazine may cause a moderate int... |
DB00402 | DB11186 | 1,407 | 1,609 | [
"DDInter685",
"DDInter1427"
] | Eszopiclone | Pentoxyverine | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1407,
24,
1609
]
],
[
[
1407,
24,
104
],
[
104,
24,
1609
]
],
[
[
1407,
63,
999
],
[
999,
24,
1609
]
],
[
[
1407,
64,
475
],
[
475,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpera... |
DB01001 | DB01255 | 688 | 633 | [
"DDInter1632",
"DDInter1078"
] | Salbutamol | Lisdexamfetamine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
688,
24,
633
]
],
[
[
688,
63,
551
],
[
551,
1,
633
]
],
[
[
688,
63,
80
],
[
80,
40,
633
]
],
[
[
688,
24,
1529
],
[
1529,
1,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Lisdexamfetami... |
DB00307 | DB12015 | 1,101 | 1,033 | [
"DDInter202",
"DDInter53"
] | Bexarotene | Alpelisib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1101,
24,
1033
]
],
[
[
1101,
24,
1135
],
[
1135,
23,
1033
]
],
[
[
1101,
24,
1254
],
[
1254,
24,
1033
]
],
[
[
1101,
25,
1510
],
[
15... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insu... |
DB00795 | DB11256 | 50 | 95 | [
"DDInter1725",
"DDInter1058"
] | Sulfasalazine | Levomefolic acid (calcium) | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | 5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-). | Minor | 0 | [
[
[
50,
23,
95
]
],
[
[
50,
63,
663
],
[
663,
24,
95
]
],
[
[
50,
62,
1147
],
[
1147,
63,
639
],
[
639,
24,
95
]
],
[
[
50,
63,
... | [
[
[
"Sulfasalazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levomefolic acid"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
... | Sulfasalazine may cause a minor interaction that can limit clinical effects when taken with Levomefolic acid
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Levomef... |
DB00615 | DB01058 | 690 | 978 | [
"DDInter1589",
"DDInter1510"
] | Rifabutin | Praziquantel | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Major | 2 | [
[
[
690,
25,
978
]
],
[
[
690,
6,
7950
],
[
7950,
45,
978
]
],
[
[
690,
21,
28709
],
[
28709,
60,
978
]
],
[
[
690,
25,
1017
],
[
1017,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Praziquantel"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Praziqu... | Rifabutin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Praziquantel (Compound)
Rifabutin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Praziquantel (Compound)
Rifabutin may lead to a major life threatening interaction when taken with Lorlatinib and ... |
DB06210 | DB11110 | 72 | 603 | [
"DDInter631",
"DDInter1115"
] | Eltrombopag | Magnesium citrate | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
72,
24,
603
]
],
[
[
72,
24,
484
],
[
484,
63,
603
]
],
[
[
72,
63,
392
],
[
392,
24,
603
]
],
[
[
72,
24,
996
],
[
996,
24,
... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib ... |
DB08865 | DB12301 | 1,593 | 907 | [
"DDInter448",
"DDInter585"
] | Crizotinib | Doravirine | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
1593,
23,
907
]
],
[
[
1593,
64,
1478
],
[
1478,
23,
907
]
],
[
[
1593,
24,
159
],
[
159,
62,
907
]
],
[
[
1593,
24,
951
],
[
951,
... | [
[
[
"Crizotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
... | Crizotinib may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may caus... |
DB00106 | DB00450 | 618 | 78 | [
"DDInter4",
"DDInter603"
] | Abarelix | Droperidol | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Major | 2 | [
[
[
618,
25,
78
]
],
[
[
618,
25,
1300
],
[
1300,
40,
78
]
],
[
[
618,
25,
1568
],
[
1568,
1,
78
]
],
[
[
618,
23,
112
],
[
112,
62,... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Haloperidol"
],
[
"Haloperidol",
"{u} (Co... | Abarelix may lead to a major life threatening interaction when taken with Haloperidol and Haloperidol (Compound) resembles Droperidol (Compound)
Abarelix may lead to a major life threatening interaction when taken with Pimozide and Pimozide (Compound) resembles Droperidol (Compound)
Abarelix may cause a minor interacti... |
DB00214 | DB00682 | 1,028 | 126 | [
"DDInter1836",
"DDInter1951"
] | Torasemide | Warfarin | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
1028,
24,
126
]
],
[
[
1028,
24,
1376
],
[
1376,
40,
126
]
],
[
[
1028,
6,
3486
],
[
3486,
45,
126
]
],
[
[
1028,
24,
135
],
[
135,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Torasemide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Torasemide may cause a moderate interaction that could exace... |
DB00207 | DB00916 | 1,570 | 112 | [
"DDInter157",
"DDInter1202"
] | Azithromycin | Metronidazole | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
1570,
23,
112
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
112
]
],
[
[
1570,
21,
29310
],
[
29310,
60,
112
]
],
[
[
1570,
63,
618
],
[
618,
... | [
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound)
Azithromycin (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Metronidazole (Compound)
Azithromycin may cause a moderate interaction that could exacerbat... |
DB00427 | DB09488 | 1,233 | 103 | [
"DDInter1879",
"DDInter23"
] | Triprolidine | Acrivastine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1233,
24,
103
]
],
[
[
1233,
23,
771
],
[
771,
62,
103
]
],
[
[
1233,
24,
1405
],
[
1405,
24,
103
]
],
[
[
1233,
63,
357
],
[
357,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Triprolidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],
... | Triprolidine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Acrivastine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprin... |
DB01169 | DB01224 | 57 | 623 | [
"DDInter120",
"DDInter1553"
] | Arsenic trioxide | Quetiapine | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Major | 2 | [
[
[
57,
25,
623
]
],
[
[
57,
64,
827
],
[
827,
1,
623
]
],
[
[
57,
63,
867
],
[
867,
1,
623
]
],
[
[
57,
6,
4973
],
[
4973,
45,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quetiapine"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trazodone"
],
[
"Trazodone",
... | Arsenic trioxide may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine (Compound) resembles Quetiapine (Compound)
Arsen... |
DB01041 | DB06273 | 770 | 980 | [
"DDInter1789",
"DDInter1824"
] | Thalidomide | Tocilizumab | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
770,
24,
980
]
],
[
[
770,
63,
1428
],
[
1428,
24,
980
]
],
[
[
770,
24,
309
],
[
309,
24,
980
]
],
[
[
770,
25,
975
],
[
975,
6... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ix... |
DB00963 | DB08896 | 1,263 | 292 | [
"DDInter241",
"DDInter1576"
] | Bromfenac | Regorafenib | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
1263,
25,
292
]
],
[
[
1263,
21,
29122
],
[
29122,
60,
292
]
],
[
[
1263,
63,
1560
],
[
1560,
24,
292
]
],
[
[
1263,
24,
1613
],
[
161... | [
[
[
"Bromfenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Bromfenac",
"{u} (Compound) causes {v} (Side Effect)",
"Mediastinal disorder"
],
[
"Mediastinal disorder",
"{u} (Side Effect) i... | Bromfenac (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Regorafenib (Compound)
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate disease... |
DB06595 | DB08916 | 1,491 | 26 | [
"DDInter1214",
"DDInter32"
] | Midostaurin | Afatinib | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
1491,
24,
26
]
],
[
[
1491,
64,
651
],
[
651,
24,
26
]
],
[
[
1491,
25,
996
],
[
996,
24,
26
]
],
[
[
1491,
24,
124
],
[
124,
63... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Midostaurin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosphenytoin"
],
[
"Fospheny... | Midostaurin may lead to a major life threatening interaction when taken with Fosphenytoin and Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Afatinib
Midostaurin may lead to a major life threatening interaction when taken with Bedaquiline and Bedaquiline may cause a moderat... |
DB00443 | DB00559 | 251 | 152 | [
"DDInter195",
"DDInter223"
] | Betamethasone | Bosentan | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Moderate | 1 | [
[
[
251,
24,
152
]
],
[
[
251,
6,
8374
],
[
8374,
45,
152
]
],
[
[
251,
18,
5795
],
[
5795,
57,
152
]
],
[
[
251,
21,
29543
],
[
29543,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosentan (Compound)
Betamethasone (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is downregulated by Bosentan (Compound)
Betamethasone (Compound) causes Contusion (Side Effect) and Contusion (Side Effect) is caused by Bosentan (Compound)... |
DB00011 | DB06317 | 1,451 | 1,626 | [
"DDInter944",
"DDInter630"
] | Interferon alfa-n1 | Elotuzumab | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
1451,
24,
1626
]
],
[
[
1451,
24,
973
],
[
973,
24,
1626
]
],
[
[
1451,
24,
310
],
[
310,
63,
1626
]
],
[
[
1451,
25,
1477
],
[
1477,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Cabaz... |
DB01234 | DB09049 | 1,220 | 1,135 | [
"DDInter513",
"DDInter1261"
] | Dexamethasone | Naloxegol | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Moderate | 1 | [
[
[
1220,
24,
1135
]
],
[
[
1220,
64,
33
],
[
33,
23,
1135
]
],
[
[
1220,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
1220,
24,
971
],
[
971,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiod... | Dexamethasone may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Dexamethasone may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor intera... |
DB00294 | DB09065 | 1,336 | 760 | [
"DDInter701",
"DDInter424"
] | Etonogestrel | Cobicistat | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1336,
24,
760
]
],
[
[
1336,
25,
1101
],
[
1101,
23,
760
]
],
[
[
1336,
24,
723
],
[
723,
24,
760
]
],
[
[
1336,
23,
14
],
[
14,
... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Etonogestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Etonogestrel may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may caus... |
DB00701 | DB01410 | 1,091 | 423 | [
"DDInter90",
"DDInter375"
] | Amprenavir | Ciclesonide | Amprenavir is a protease inhibitor used to treat HIV infection. | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Moderate | 1 | [
[
[
1091,
24,
423
]
],
[
[
1091,
63,
1573
],
[
1573,
1,
423
]
],
[
[
1091,
63,
1351
],
[
1351,
40,
423
]
],
[
[
1091,
25,
1486
],
[
1486,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compou... |
DB01246 | DB01618 | 820 | 776 | [
"DDInter45",
"DDInter1239"
] | Alimemazine | Molindone | A phenothiazine derivative that is used as an antipruritic. | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
820,
24,
776
]
],
[
[
820,
18,
6797
],
[
6797,
57,
776
]
],
[
[
820,
21,
28800
],
[
28800,
60,
776
]
],
[
[
820,
63,
100
],
[
100,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Alimemazine",
"{u} (Compound) downregulates {v} (Gene)",
"CYCS"
],
[
"CYCS",
"{u} (Gene) is downregulated by {v}... | Alimemazine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Molindone (Compound)
Alimemazine (Compound) causes Dyskinesia (Side Effect) and Dyskinesia (Side Effect) is caused by Molindone (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Brom... |
DB00620 | DB09473 | 175 | 884 | [
"DDInter1855",
"DDInter918"
] | Triamcinolone | Indium In-111 oxyquinoline | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
175,
24,
884
]
],
[
[
175,
40,
870
],
[
870,
24,
884
]
],
[
[
175,
1,
617
],
[
617,
24,
884
]
],
[
[
175,
25,
609
],
[
609,
24,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Triamcinolone",
"{u} (Compound) resembles {v} (Compound)",
"Fludrocortisone"
],
[
"Fludrocortisone"... | Triamcinolone (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Triamcinolone (Compound) resembles Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate dise... |
DB00586 | DB00761 | 1,512 | 1,621 | [
"DDInter537",
"DDInter1497"
] | Diclofenac | Potassium chloride | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Moderate | 1 | [
[
[
1512,
24,
1621
]
],
[
[
1512,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
1512,
35,
1338
],
[
1338,
63,
1621
]
],
[
[
1512,
63,
831
],
[
8... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium chloride"
]
],
[
[
"Diclofenac",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect)... | Diclofenac (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Diclofenac (Compound) resembles Meclofenamic acid (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid ... |
DB00373 | DB13142 | 461 | 841 | [
"DDInter1809",
"DDInter274"
] | Timolol | Calcium glubionate anhydrous | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
461,
24,
841
]
],
[
[
461,
1,
729
],
[
729,
24,
841
]
],
[
[
461,
62,
1152
],
[
1152,
24,
841
]
],
[
[
461,
23,
542
],
[
542,
24... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Timolol",
"{u} (Compound) resembles {v} (Compound)",
"Penbutolol"
],
[
"Penbutolol",
"{u} may cau... | Timolol (Compound) resembles Penbutolol (Compound) and Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Timolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate interact... |
DB01276 | DB01364 | 123 | 22 | [
"DDInter706",
"DDInter650"
] | Exenatide | Ephedrine | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
123,
24,
22
]
],
[
[
123,
24,
1529
],
[
1529,
63,
22
]
],
[
[
123,
24,
280
],
[
280,
1,
22
]
],
[
[
123,
63,
1445
],
[
1445,
1,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine and ... |
DB00014 | DB01246 | 521 | 820 | [
"DDInter839",
"DDInter45"
] | Goserelin | Alimemazine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
521,
24,
820
]
],
[
[
521,
24,
401
],
[
401,
24,
820
]
],
[
[
521,
24,
675
],
[
675,
25,
820
]
],
[
[
521,
24,
508
],
[
508,
1,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene... |
DB00388 | DB01309 | 1,636 | 1,254 | [
"DDInter1453",
"DDInter933"
] | Phenylephrine | Insulin glulisine | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1636,
24,
1254
]
],
[
[
1636,
63,
1645
],
[
1645,
24,
1254
]
],
[
[
1636,
24,
887
],
[
887,
24,
1254
]
],
[
[
1636,
24,
1529
],
[
1529... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol a... |
DB00445 | DB06402 | 322 | 1,079 | [
"DDInter655",
"DDInter1756"
] | Epirubicin | Telavancin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
322,
24,
1079
]
],
[
[
322,
21,
28775
],
[
28775,
60,
1079
]
],
[
[
322,
23,
112
],
[
112,
23,
1079
]
],
[
[
322,
24,
543
],
[
543,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Epirubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Phlebitis"
],
[
"Phlebitis",
"{u} (Side Effect) is caus... | Epirubicin (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Telavancin (Compound)
Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telav... |
DB00877 | DB15982 | 629 | 1,339 | [
"DDInter1678",
"DDInter193"
] | Sirolimus | Berotralstat | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
629,
24,
1339
]
],
[
[
629,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
629,
24,
222
],
[
222,
23,
1339
]
],
[
[
629,
24,
761
],
[
761,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutra... |
DB00514 | DB11160 | 506 | 337 | [
"DDInter527",
"DDInter1459"
] | Dextromethorphan | Phenyltoloxamine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
506,
24,
337
]
],
[
[
506,
24,
820
],
[
820,
24,
337
]
],
[
[
506,
63,
999
],
[
999,
24,
337
]
],
[
[
506,
25,
1053
],
[
1053,
2... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazi... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00679 | DB09038 | 684 | 1,450 | [
"DDInter1796",
"DDInter636"
] | Thioridazine | Empagliflozin | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
684,
24,
1450
]
],
[
[
684,
25,
485
],
[
485,
24,
1450
]
],
[
[
684,
24,
659
],
[
659,
63,
1450
]
],
[
[
684,
63,
1179
],
[
1179,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
],
[
"Pe... | Thioridazine may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol m... |
DB00619 | DB01577 | 1,419 | 1,529 | [
"DDInter909",
"DDInter1161"
] | Imatinib | Metamfetamine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1419,
24,
1529
]
],
[
[
1419,
24,
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],
[
136,
1,
1529
]
],
[
[
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63,
80
],
[
80,
40,
1529
]
],
[
[
1419,
24,
1039
],
[
1039,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lacosamide"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Lacosamide and Lacosamide (Compound) resembles Metamfetamine (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Metamfetamine (Compou... |
DB00005 | DB08904 | 1,057 | 375 | [
"DDInter687",
"DDInter342"
] | Etanercept | Certolizumab pegol | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
1057,
25,
375
]
],
[
[
1057,
23,
1461
],
[
1461,
23,
375
]
],
[
[
1057,
23,
1193
],
[
1193,
62,
375
]
],
[
[
1057,
24,
231
],
[
231,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitam... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zi... |
DB00843 | DB12500 | 479 | 283 | [
"DDInter583",
"DDInter714"
] | Donepezil | Fedratinib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Minor | 0 | [
[
[
479,
23,
283
]
],
[
[
479,
23,
351
],
[
351,
23,
283
]
],
[
[
479,
62,
1419
],
[
1419,
24,
283
]
],
[
[
479,
40,
843
],
[
843,
2... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fedratinib"
]
],
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ribociclib"
],
[
"R... | Donepezil may cause a minor interaction that can limit clinical effects when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Donepezil may cause a minor interaction that can limit clinical effects when taken with Imatinib and Imatinib may cau... |
DB00539 | DB00549 | 11 | 522 | [
"DDInter1837",
"DDInter1955"
] | Toremifene | Zafirlukast | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
11,
24,
522
]
],
[
[
11,
6,
7950
],
[
7950,
45,
522
]
],
[
[
11,
21,
28698
],
[
28698,
60,
522
]
],
[
[
11,
24,
479
],
[
479,
62... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)"... | Toremifene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Zafirlukast (Compound)
Toremifene (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Zafirlukast (Compound)
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donep... |
DB01096 | DB09293 | 678 | 116 | [
"DDInter1356",
"DDInter954"
] | Oxamniquine | Iodide I-131 | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Ex... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
678,
24,
116
]
],
[
[
678,
25,
497
],
[
497,
24,
116
]
],
[
[
678,
6,
12523
],
[
12523,
45,
436
],
[
436,
24,
116
]
],
[
[
678,
... | [
[
[
"Oxamniquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Oxamniquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",... | Oxamniquine may lead to a major life threatening interaction when taken with Iohexol and Iohexol may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Oxamniquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Artemether (Compound) and Artemether may cause a moderate... |
DB00727 | DB01142 | 685 | 1,264 | [
"DDInter1304",
"DDInter593"
] | Nitroglycerin | Doxepin | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
685,
24,
1264
]
],
[
[
685,
24,
401
],
[
401,
24,
1264
]
],
[
[
685,
21,
28734
],
[
28734,
60,
1264
]
],
[
[
685,
62,
352
],
[
352,
... | [
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Nitroglycerin (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect... |
DB00322 | DB10316 | 141 | 334 | [
"DDInter742",
"DDInter1248"
] | Floxuridine | Mumps virus strain B level jeryl lynn live antigen | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
141,
25,
334
]
],
[
[
141,
64,
1057
],
[
1057,
25,
334
]
],
[
[
141,
24,
328
],
[
328,
25,
334
]
],
[
[
141,
25,
908
],
[
908,
2... | [
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Floxuridine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptop... |
DB00544 | DB14811 | 970 | 385 | [
"DDInter757",
"DDInter979"
] | Fluorouracil | Isatuximab | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
970,
24,
385
]
],
[
[
970,
24,
1362
],
[
1362,
24,
385
]
],
[
[
970,
64,
377
],
[
377,
24,
385
]
],
[
[
970,
63,
134
],
[
134,
2... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Fluorouracil may lead to a major life threatening interaction when taken with Mitomycin and Mitomycin may cause a ... |
DB00394 | DB15091 | 218 | 676 | [
"DDInter168",
"DDInter1901"
] | Beclomethasone dipropionate | Upadacitinib | Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone]. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Bec... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
218,
25,
676
]
],
[
[
218,
25,
932
],
[
932,
24,
676
]
],
[
[
218,
1,
891
],
[
891,
25,
676
]
],
[
[
218,
24,
589
],
[
589,
25,
... | [
[
[
"Beclomethasone dipropionate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Beclomethasone dipropionate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
],
... | Beclomethasone dipropionate may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Beclomethasone dipropionate (Compound) resembles Prednisolone (Compound) and Prednisolone may lead to a ... |
DB01619 | DB11642 | 830 | 938 | [
"DDInter1441",
"DDInter1480"
] | Phenindamine | Pitolisant | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
830,
24,
938
]
],
[
[
830,
63,
1233
],
[
1233,
24,
938
]
],
[
[
830,
24,
516
],
[
516,
24,
938
]
],
[
[
830,
1,
1219
],
[
1219,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine and Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizin... |
DB01229 | DB01241 | 973 | 1,206 | [
"DDInter1378",
"DDInter812"
] | Paclitaxel (protein-bound) | Gemfibrozil | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Moderate | 1 | [
[
[
973,
24,
1206
]
],
[
[
973,
6,
8374
],
[
8374,
45,
1206
]
],
[
[
973,
18,
19811
],
[
19811,
46,
1206
]
],
[
[
973,
7,
20003
],
[
20003... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemfibrozil"
]
],
[
[
"Paclitaxel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Paclitaxel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Gemfibrozil (Compound)
Paclitaxel (Compound) downregulates MLLT11 (Gene) and MLLT11 (Gene) is upregulated by Gemfibrozil (Compound)
Paclitaxel (C... |
DB00570 | DB00745 | 147 | 307 | [
"DDInter1936",
"DDInter1236"
] | Vinblastine | Modafinil | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
147,
23,
307
]
],
[
[
147,
63,
362
],
[
362,
40,
307
]
],
[
[
147,
24,
651
],
[
651,
40,
307
]
],
[
[
147,
6,
8374
],
[
8374,
45... | [
[
[
"Vinblastine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin (Compound) resembles Modafinil (Compound... |
DB00960 | DB01088 | 887 | 714 | [
"DDInter1471",
"DDInter908"
] | Pindolol | Iloprost | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
887,
24,
714
]
],
[
[
887,
62,
1479
],
[
1479,
24,
714
]
],
[
[
887,
63,
1648
],
[
1648,
24,
714
]
],
[
[
887,
40,
1121
],
[
1121,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Pindolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
],
[
... | Pindolol may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleuk... |
DB00443 | DB01259 | 251 | 392 | [
"DDInter195",
"DDInter1024"
] | Betamethasone | Lapatinib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
251,
24,
392
]
],
[
[
251,
10,
11579
],
[
11579,
44,
392
]
],
[
[
251,
6,
4973
],
[
4973,
45,
392
]
],
[
[
251,
7,
3727
],
[
3727,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Betamethasone",
"{u} (Compound) palliates {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease)... | Betamethasone (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Betamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Betamethasone (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Be... |
DB00581 | DB11642 | 355 | 938 | [
"DDInter1018",
"DDInter1480"
] | Lactulose | Pitolisant | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
355,
24,
938
]
],
[
[
355,
24,
28
],
[
28,
24,
938
]
],
[
[
355,
63,
600
],
[
600,
24,
938
]
],
[
[
355,
24,
927
],
[
927,
63,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazo... |
DB11130 | DB14881 | 407 | 180 | [
"DDInter1344",
"DDInter1329"
] | Opium | Oliceridine | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
407,
24,
180
]
],
[
[
407,
63,
401
],
[
401,
24,
180
]
],
[
[
407,
24,
1259
],
[
1259,
24,
180
]
],
[
[
407,
64,
593
],
[
593,
2... | [
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Pr... | Opium may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Opium may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib and Baricitini... |
DB00563 | DB09133 | 663 | 1,527 | [
"DDInter1174",
"DDInter965"
] | Methotrexate | Iothalamic acid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
663,
25,
1527
]
],
[
[
663,
24,
1577
],
[
1577,
24,
1527
]
],
[
[
663,
63,
1014
],
[
1014,
24,
1527
]
],
[
[
663,
24,
242
],
[
242,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
],
[
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00910 | DB01211 | 1,041 | 609 | [
"DDInter1394",
"DDInter393"
] | Paricalcitol | Clarithromycin | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1041,
24,
609
]
],
[
[
1041,
6,
8374
],
[
8374,
45,
609
]
],
[
[
1041,
21,
28759
],
[
28759,
60,
609
]
],
[
[
1041,
24,
34
],
[
34,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Paricalcitol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Paricalcitol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Paricalcitol (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Clarithromycin (Compound)
Paricalcitol may cause a moderate interaction that could exacerb... |
DB00867 | DB01268 | 1,052 | 1,151 | [
"DDInter1606",
"DDInter1731"
] | Ritodrine | Sunitinib | Adrenergic beta-agonist used to control premature labor. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1052,
24,
1151
]
],
[
[
1052,
18,
2183
],
[
2183,
57,
1151
]
],
[
[
1052,
24,
1148
],
[
1148,
24,
1151
]
],
[
[
1052,
24,
1250
],
[
12... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Ritodrine",
"{u} (Compound) downregulates {v} (Gene)",
"CDC20"
],
[
"CDC20",
"{u} (Gene) is downregulated by {v} (... | Ritodrine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Sunitinib (Compound)
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Rito... |
DB00475 | DB01041 | 1,119 | 770 | [
"DDInter355",
"DDInter1789"
] | Chlordiazepoxide | Thalidomide | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1119,
24,
770
]
],
[
[
1119,
24,
609
],
[
609,
63,
770
]
],
[
[
1119,
1,
1563
],
[
1563,
24,
770
]
],
[
[
1119,
24,
1614
],
[
1614,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Chlordiazepoxide (Compound) resembles Halazepam (Compound) and Halazepam may cause a moderate int... |
DB00047 | DB01144 | 176 | 1,326 | [
"DDInter932",
"DDInter540"
] | Insulin glargine | Diclofenamide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Moderate | 1 | [
[
[
176,
24,
1326
]
],
[
[
176,
24,
504
],
[
504,
1,
1326
]
],
[
[
176,
24,
359
],
[
359,
40,
1326
]
],
[
[
176,
24,
1620
],
[
1620,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorot... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (C... |
DB00448 | DB01764 | 1,215 | 805 | [
"DDInter1022",
"DDInter469"
] | Lansoprazole | Dalfopristin | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
1215,
24,
805
]
],
[
[
1215,
6,
8374
],
[
8374,
45,
805
]
],
[
[
1215,
24,
283
],
[
283,
62,
805
]
],
[
[
1215,
24,
609
],
[
609,
... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Lansoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Lansoprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Lansoprazole... |
DB01058 | DB15093 | 978 | 1,654 | [
"DDInter1510",
"DDInter1698"
] | Praziquantel | Somapacitan | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
978,
24,
1654
]
],
[
[
978,
24,
351
],
[
351,
24,
1654
]
],
[
[
978,
25,
129
],
[
129,
24,
1654
]
],
[
[
978,
63,
1324
],
[
1324,
... | [
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
... | Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Praziquantel may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide m... |
DB00754 | DB04865 | 157 | 4 | [
"DDInter696",
"DDInter1335"
] | Ethotoin | Omacetaxine mepesuccinate | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
157,
24,
4
]
],
[
[
157,
7,
7248
],
[
7248,
46,
4
]
],
[
[
157,
18,
3950
],
[
3950,
57,
4
]
],
[
[
157,
24,
770
],
[
770,
24,
... | [
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Ethotoin",
"{u} (Compound) upregulates {v} (Gene)",
"RPP38"
],
[
"RPP38",
"{u} (Gene) is upregulate... | Ethotoin (Compound) upregulates RPP38 (Gene) and RPP38 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Ethotoin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB06688 | DB11581 | 1,430 | 1,456 | [
"DDInter1677",
"DDInter1926"
] | Sipuleucel-T | Venetoclax | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
1430,
24,
1456
]
],
[
[
1430,
63,
259
],
[
259,
24,
1456
]
],
[
[
1430,
24,
1476
],
[
1476,
63,
1456
]
],
[
[
1430,
24,
812
],
[
812,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Br... |
DB00959 | DB09082 | 1,486 | 659 | [
"DDInter1191",
"DDInter1934"
] | Methylprednisolone | Vilanterol | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Minor | 0 | [
[
[
1486,
23,
659
]
],
[
[
1486,
40,
1220
],
[
1220,
23,
659
]
],
[
[
1486,
1,
175
],
[
175,
23,
659
]
],
[
[
1486,
24,
1296
],
[
1296,
... | [
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vilanterol"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
"{u}... | Methylprednisolone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Methylprednisolone (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a minor interaction that can limit clinical effects whe... |
DB00694 | DB00697 | 51 | 876 | [
"DDInter485",
"DDInter1821"
] | Daunorubicin | Tizanidine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
51,
24,
876
]
],
[
[
51,
6,
7950
],
[
7950,
45,
876
]
],
[
[
51,
18,
6718
],
[
6718,
57,
876
]
],
[
[
51,
21,
28882
],
[
28882,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compoun... | Daunorubicin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Tizanidine (Compound)
Daunorubicin (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Tizanidine (Compound)
Daunorubicin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effec... |
DB00552 | DB01155 | 1,238 | 872 | [
"DDInter1425",
"DDInter813"
] | Pentostatin | Gemifloxacin | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
1238,
23,
872
]
],
[
[
1238,
23,
739
],
[
739,
1,
872
]
],
[
[
1238,
62,
1467
],
[
1467,
1,
872
]
],
[
[
1238,
23,
945
],
[
945,
... | [
[
[
"Pentostatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Pentostatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Pentostatin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Pentostatin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Gemifloxacin (Compound... |
DB04946 | DB14568 | 924 | 982 | [
"DDInter907",
"DDInter1000"
] | Iloperidone | Ivosidenib | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
924,
25,
982
]
],
[
[
924,
62,
112
],
[
112,
23,
982
]
],
[
[
924,
63,
543
],
[
543,
24,
982
]
],
[
[
924,
24,
28
],
[
28,
24,
... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Iloperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Iloperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lo... |
DB08865 | DB09079 | 1,593 | 1,496 | [
"DDInter448",
"DDInter1296"
] | Crizotinib | Nintedanib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
1593,
24,
1496
]
],
[
[
1593,
64,
33
],
[
33,
24,
1496
]
],
[
[
1593,
25,
74
],
[
74,
24,
1496
]
],
[
[
1593,
24,
1412
],
[
1412,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiodarone... | Crizotinib may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Crizotinib may lead to a major life threatening interaction when taken with Boceprevir and Boceprevir may cause a moderate inte... |
DB01149 | DB14568 | 851 | 982 | [
"DDInter1274",
"DDInter1000"
] | Nefazodone | Ivosidenib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
851,
25,
982
]
],
[
[
851,
63,
168
],
[
168,
23,
982
]
],
[
[
851,
62,
1101
],
[
1101,
23,
982
]
],
[
[
851,
25,
976
],
[
976,
2... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomib... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Nefazodone may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene... |
DB00163 | DB00945 | 1,461 | 1,479 | [
"DDInter1943",
"DDInter20"
] | Vitamin E | Acetylsalicylic acid | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1461,
24,
1479
]
],
[
[
1461,
24,
714
],
[
714,
63,
1479
]
],
[
[
1461,
63,
1578
],
[
1578,
24,
1479
]
],
[
[
1461,
23,
1486
],
[
1486... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lep... |
DB00455 | DB00745 | 1,601 | 307 | [
"DDInter1091",
"DDInter1236"
] | Loratadine | Modafinil | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
1601,
23,
307
]
],
[
[
1601,
24,
1335
],
[
1335,
40,
307
]
],
[
[
1601,
6,
10215
],
[
10215,
45,
307
]
],
[
[
1601,
21,
28898
],
[
288... | [
[
[
"Loratadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
],
[
... | Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Modafinil (Compound)
Loratadine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Modafinil (Compound)
Loratadine (Compound) causes Constipation (Side Effect) and ... |
DB00731 | DB01406 | 1,144 | 984 | [
"DDInter1269",
"DDInter472"
] | Nateglinide | Danazol | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
1144,
24,
984
]
],
[
[
1144,
63,
989
],
[
989,
1,
984
]
],
[
[
1144,
24,
1546
],
[
1546,
1,
984
]
],
[
[
1144,
63,
1026
],
[
1026,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
],
[
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Danazol (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Dan... |
DB01004 | DB01229 | 563 | 973 | [
"DDInter806",
"DDInter1377"
] | Ganciclovir | Paclitaxel | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
563,
24,
973
]
],
[
[
563,
24,
310
],
[
310,
63,
973
]
],
[
[
563,
18,
10375
],
[
10375,
57,
973
]
],
[
[
563,
21,
29267
],
[
29267,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Ganciclovir (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Paclitaxel (Compound... |
DB06704 | DB08918 | 247 | 41 | [
"DDInter951",
"DDInter1059"
] | Iobenguane (I-123) | Levomilnacipran | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
247,
37,
41
]
],
[
[
247,
76,
901
],
[
901,
40,
41
]
],
[
[
247,
6,
7390
],
[
7390,
45,
41
]
],
[
[
247,
21,
28921
],
[
28921,
6... | [
[
[
"Iobenguane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Iobenguane",
"{u} may cause a moderate interaction that ... | Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Iobenguane may lead to a major life threatening interaction when taken with Levomilnacipran
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Iobenguane... |
DB00365 | DB12141 | 839 | 971 | [
"DDInter842",
"DDInter817"
] | Grepafloxacin | Gilteritinib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
839,
25,
971
]
],
[
[
839,
23,
112
],
[
112,
23,
971
]
],
[
[
839,
25,
485
],
[
485,
24,
971
]
],
[
[
839,
25,
823
],
[
823,
63,... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Grepafloxacin may lead to a major life threatening interaction when taken with Pentamidine and Pentamidin... |
DB01128 | DB11113 | 918 | 657 | [
"DDInter204",
"DDInter307"
] | Bicalutamide | Castor oil | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
918,
24,
657
]
],
[
[
918,
24,
1079
],
[
1079,
24,
657
]
],
[
[
918,
24,
927
],
[
927,
63,
657
]
],
[
[
918,
25,
540
],
[
540,
2... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and E... |
DB01004 | DB01005 | 563 | 995 | [
"DDInter806",
"DDInter894"
] | Ganciclovir | Hydroxyurea | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
563,
24,
995
]
],
[
[
563,
21,
29429
],
[
29429,
60,
995
]
],
[
[
563,
63,
1238
],
[
1238,
24,
995
]
],
[
[
563,
24,
869
],
[
869,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Ganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Infestation NOS"
],
[
"Infestation NOS",
"{u} (Side ... | Ganciclovir (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Hydroxyurea (Compound)
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Pentostatin and Pentostatin may cause a moderate interaction that could exacerbate diseases when t... |
DB00424 | DB00454 | 19 | 1,349 | [
"DDInter896",
"DDInter1150"
] | Hyoscyamine | Meperidine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Moderate | 1 | [
[
[
19,
24,
1349
]
],
[
[
19,
40,
11228
],
[
11228,
1,
1349
]
],
[
[
19,
24,
411
],
[
411,
1,
1349
]
],
[
[
19,
21,
28717
],
[
28717,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meperidine"
]
],
[
[
"Hyoscyamine",
"{u} (Compound) resembles {v} (Compound)",
"Cyclopentolate"
],
[
"Cyclopentolate",
"{u} (Compound... | Hyoscyamine (Compound) resembles Cyclopentolate (Compound) and Cyclopentolate (Compound) resembles Meperidine (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Remifentanil and Remifentanil (Compound) resembles Meperidine (Compound)
Hyoscyamine (Compound) causes Flus... |
DB01222 | DB14740 | 617 | 771 | [
"DDInter246",
"DDInter881"
] | Budesonide | Hyaluronidase | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
617,
23,
771
]
],
[
[
617,
63,
1438
],
[
1438,
23,
771
]
],
[
[
617,
40,
167
],
[
167,
23,
771
]
],
[
[
617,
24,
35
],
[
35,
23,... | [
[
[
"Budesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Budesonide (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction that c... |
DB00099 | DB14962 | 440 | 1,363 | [
"DDInter735",
"DDInter1847"
] | Filgrastim | Trastuzumab deruxtecan | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes i... | Moderate | 1 | [
[
[
440,
24,
1363
]
],
[
[
440,
24,
384
],
[
384,
24,
1363
]
],
[
[
440,
63,
599
],
[
599,
24,
1363
]
],
[
[
440,
25,
1064
],
[
1064,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab deruxtecan"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab deruxtecan
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzum... |
DB00544 | DB08868 | 970 | 1,011 | [
"DDInter757",
"DDInter737"
] | Fluorouracil | Fingolimod | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
970,
25,
1011
]
],
[
[
970,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
970,
24,
112
],
[
112,
23,
1011
]
],
[
[
970,
24,
748
],
[
748,
... | [
[
[
"Fluorouracil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Fluorouracil",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Effect) is cause... | Fluorouracil (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when ... |
DB00055 | DB01088 | 834 | 714 | [
"DDInter605",
"DDInter908"
] | Drotrecogin alfa | Iloprost | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Major | 2 | [
[
[
834,
25,
714
]
],
[
[
834,
23,
539
],
[
539,
62,
714
]
],
[
[
834,
24,
383
],
[
383,
24,
714
]
],
[
[
834,
25,
1479
],
[
1479,
2... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloprost"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Caps... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Iloprost
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfat... |
DB01064 | DB13074 | 1,148 | 877 | [
"DDInter987",
"DDInter1110"
] | Isoprenaline | Macimorelin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1148,
25,
877
]
],
[
[
1148,
35,
1191
],
[
1191,
24,
877
]
],
[
[
1148,
24,
673
],
[
673,
24,
877
]
],
[
[
1148,
63,
176
],
[
176,
... | [
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Isoprenaline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Isoprenaline (Compound) resembles Levodopa (Compound) and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Isoprenaline may cause a moderate interaction that coul... |
DB00951 | DB12130 | 1,072 | 1,017 | [
"DDInter986",
"DDInter1094"
] | Isoniazid | Lorlatinib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1072,
24,
1017
]
],
[
[
1072,
63,
590
],
[
590,
24,
1017
]
],
[
[
1072,
62,
175
],
[
175,
24,
1017
]
],
[
[
1072,
24,
14
],
[
14,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Isoniazid may cause a minor interaction that can limit clinical effects when taken with Triamcinolone and T... |
DB00215 | DB08899 | 1,230 | 129 | [
"DDInter388",
"DDInter649"
] | Citalopram | Enzalutamide | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1230,
25,
129
]
],
[
[
1230,
25,
918
],
[
918,
1,
129
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1230,
21,
29377
],
[
29377,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Citalopram may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Citalopram (Compound) causes Musculoskeletal pain (Side Effect) and Muscu... |
DB00976 | DB04868 | 1,056 | 478 | [
"DDInter1758",
"DDInter1293"
] | Telithromycin | Nilotinib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1056,
25,
478
]
],
[
[
1056,
25,
1468
],
[
1468,
63,
478
]
],
[
[
1056,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1056,
21,
28963
],
[
28963... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u... | Telithromycin may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Telithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Telithromycin (Compound) causes... |
DB00008 | DB05528 | 491 | 1,070 | [
"DDInter1407",
"DDInter1228"
] | Peginterferon alfa-2a | Mipomersen | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
491,
25,
1070
]
],
[
[
491,
24,
14
],
[
14,
25,
1070
]
],
[
[
491,
24,
350
],
[
350,
64,
1070
]
],
[
[
491,
25,
593
],
[
593,
25... | [
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
],... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may lead to a major life threatening interaction when taken with Mipomersen
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomi... |
DB00637 | DB06448 | 1,557 | 171 | [
"DDInter128",
"DDInter1087"
] | Astemizole | Lonafarnib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
1557,
24,
171
]
],
[
[
1557,
24,
888
],
[
888,
24,
171
]
],
[
[
1557,
23,
112
],
[
112,
24,
171
]
],
[
[
1557,
64,
1424
],
[
1424,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metroni... |
DB01041 | DB01601 | 770 | 833 | [
"DDInter1789",
"DDInter1089"
] | Thalidomide | Lopinavir | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Moderate | 1 | [
[
[
770,
24,
833
]
],
[
[
770,
24,
1327
],
[
1327,
40,
833
]
],
[
[
770,
6,
6017
],
[
6017,
45,
833
]
],
[
[
770,
63,
752
],
[
752,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Thalidomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lopinavir (Compound)
Thalidomide may cause a moderate interaction that could exacerbate... |
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