drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00092 | DB09123 | 58 | 1,525 | [
"DDInter40",
"DDInter546"
] | Alefacept | Dienogest | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in... | Moderate | 1 | [
[
[
58,
24,
1525
]
],
[
[
58,
25,
1064
],
[
1064,
24,
1525
]
],
[
[
58,
24,
980
],
[
980,
24,
1525
]
],
[
[
58,
24,
1303
],
[
1303,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dienogest"
]
],
[
[
"Alefacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladribine",
... | Alefacept may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Dienogest
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab and Tocilizumab may cause a... |
DB00843 | DB12245 | 479 | 823 | [
"DDInter583",
"DDInter1863"
] | Donepezil | Triclabendazole | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
479,
24,
823
]
],
[
[
479,
24,
112
],
[
112,
23,
823
]
],
[
[
479,
63,
1010
],
[
1010,
24,
823
]
],
[
[
479,
24,
77
],
[
77,
24,... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and... |
DB00344 | DB00424 | 1,302 | 19 | [
"DDInter1543",
"DDInter896"
] | Protriptyline | Hyoscyamine | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
1302,
24,
19
]
],
[
[
1302,
25,
1166
],
[
1166,
1,
19
]
],
[
[
1302,
24,
85
],
[
85,
63,
19
]
],
[
[
1302,
25,
290
],
[
290,
40,... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
],
[
"Dol... | Protriptyline may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate ... |
DB06016 | DB11130 | 1,508 | 407 | [
"DDInter300",
"DDInter1344"
] | Cariprazine | Opium | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1508,
24,
407
]
],
[
[
1508,
63,
662
],
[
662,
24,
407
]
],
[
[
1508,
24,
849
],
[
849,
24,
407
]
],
[
[
1508,
64,
475
],
[
475,
... | [
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Cariprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Cariprazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mep... |
DB01229 | DB09054 | 973 | 384 | [
"DDInter1377",
"DDInter905"
] | Paclitaxel | Idelalisib | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
973,
24,
384
]
],
[
[
973,
24,
555
],
[
555,
23,
384
]
],
[
[
973,
62,
307
],
[
307,
23,
384
]
],
[
[
973,
24,
1618
],
[
1618,
2... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netupitant may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil m... |
DB00736 | DB06589 | 660 | 1,250 | [
"DDInter676",
"DDInter1400"
] | Esomeprazole | Pazopanib | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
660,
25,
1250
]
],
[
[
660,
10,
11570
],
[
11570,
44,
1250
]
],
[
[
660,
6,
8374
],
[
8374,
45,
1250
]
],
[
[
660,
21,
29203
],
[
2920... | [
[
[
"Esomeprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Esomeprazole",
"{u} (Compound) palliates {v} (Disease)",
"kidney cancer"
],
[
"kidney cancer",
"{u} (Disease) is treated by {v... | Esomeprazole (Compound) palliates kidney cancer (Disease) and kidney cancer (Disease) is treated by Pazopanib (Compound)
Esomeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound)
Esomeprazole (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotra... |
DB00328 | DB06754 | 831 | 707 | [
"DDInter921",
"DDInter471"
] | Indomethacin | Danaparoid | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
831,
25,
707
]
],
[
[
831,
24,
121
],
[
121,
24,
707
]
],
[
[
831,
63,
1560
],
[
1560,
24,
707
]
],
[
[
831,
24,
738
],
[
738,
6... | [
[
[
"Indomethacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
[
"Fenf... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase ... |
DB00581 | DB01182 | 355 | 371 | [
"DDInter1018",
"DDInter1534"
] | Lactulose | Propafenone | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
355,
24,
371
]
],
[
[
355,
63,
847
],
[
847,
1,
371
]
],
[
[
355,
24,
675
],
[
675,
40,
371
]
],
[
[
355,
21,
28809
],
[
28809,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Propa... |
DB00242 | DB14762 | 1,064 | 994 | [
"DDInter392",
"DDInter1602"
] | Cladribine | Risankizumab | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Major | 2 | [
[
[
1064,
25,
994
]
],
[
[
1064,
63,
1461
],
[
1461,
23,
994
]
],
[
[
1064,
25,
4
],
[
4,
24,
994
]
],
[
[
1064,
64,
58
],
[
58,
24,... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risankizumab"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Cladribine may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetax... |
DB00570 | DB11943 | 147 | 255 | [
"DDInter1936",
"DDInter495"
] | Vinblastine | Delafloxacin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
147,
23,
255
]
],
[
[
147,
62,
63
],
[
63,
23,
255
]
],
[
[
147,
24,
1001
],
[
1001,
23,
255
]
],
[
[
147,
63,
377
],
[
377,
23,... | [
[
[
"Vinblastine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Vinblastine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Teniposide"
],
[
... | Vinblastine may cause a minor interaction that can limit clinical effects when taken with Teniposide and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and M... |
DB00719 | DB06702 | 1,219 | 573 | [
"DDInter149",
"DDInter731"
] | Azatadine | Fesoterodine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1219,
24,
573
]
],
[
[
1219,
24,
211
],
[
211,
1,
573
]
],
[
[
1219,
63,
494
],
[
494,
1,
573
]
],
[
[
1219,
6,
8374
],
[
8374,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (Co... |
DB09312 | DB08895 | 967 | 976 | [
"DDInter106",
"DDInter1825"
] | Antithymocyte immunoglobulin (rabbit) | Tofacitinib | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
967,
25,
976
]
],
[
[
967,
23,
1193
],
[
1193,
62,
976
]
],
[
[
967,
23,
1461
],
[
1461,
23,
976
]
],
[
[
967,
24,
200
],
[
200,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v... | Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Tofacitinib
Antilymphocyte immunoglobulin (horse) may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical e... |
DB06626 | DB11952 | 263 | 800 | [
"DDInter147",
"DDInter612"
] | Axitinib | Duvelisib | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
263,
24,
800
]
],
[
[
263,
63,
663
],
[
663,
24,
800
]
],
[
[
263,
24,
578
],
[
578,
24,
800
]
],
[
[
263,
25,
1017
],
[
1017,
6... | [
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagre... |
DB01254 | DB08913 | 1,213 | 1,186 | [
"DDInter484",
"DDInter1561"
] | Dasatinib | Radium Ra 223 dichloride | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1213,
24,
1186
]
],
[
[
1213,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
1213,
24,
1491
],
[
1491,
24,
1186
]
],
[
[
1213,
64,
1172
],
[
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Dasatinib",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) i... | Dasatinib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01041 | DB10795 | 770 | 221 | [
"DDInter1789",
"DDInter1486"
] | Thalidomide | Poliovirus type 1 antigen (formaldehyde inactivated) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
770,
24,
221
]
],
[
[
770,
24,
36
],
[
36,
24,
221
]
],
[
[
770,
64,
581
],
[
581,
24,
221
]
],
[
[
770,
63,
599
],
[
599,
24,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Thalidomide may lead to a major life threatening interaction when taken w... |
DB06603 | DB09054 | 39 | 384 | [
"DDInter1387",
"DDInter905"
] | Panobinostat | Idelalisib | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
39,
24,
384
]
],
[
[
39,
64,
318
],
[
318,
23,
384
]
],
[
[
39,
24,
1627
],
[
1627,
62,
384
]
],
[
[
39,
63,
307
],
[
307,
23,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Esci... | Panobinostat may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol ma... |
DB06210 | DB06595 | 72 | 1,491 | [
"DDInter631",
"DDInter1214"
] | Eltrombopag | Midostaurin | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
72,
24,
1491
]
],
[
[
72,
63,
289
],
[
289,
24,
1491
]
],
[
[
72,
24,
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],
[
1017,
63,
1491
]
],
[
[
72,
25,
990
],
[
990,
63... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cerivastatin"
],
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Cerivastatin and Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and... |
DB00278 | DB08875 | 291 | 1,618 | [
"DDInter117",
"DDInter262"
] | Argatroban | Cabozantinib | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
291,
25,
1618
]
],
[
[
291,
24,
41
],
[
41,
63,
1618
]
],
[
[
291,
25,
283
],
[
283,
63,
1618
]
],
[
[
291,
24,
222
],
[
222,
24... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"Lev... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Argatroban may lead to a major life threatening interaction when taken with Fedratinib and Fedratini... |
DB00376 | DB00470 | 1,105 | 530 | [
"DDInter1870",
"DDInter601"
] | Trihexyphenidyl | Dronabinol | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1105,
24,
530
]
],
[
[
1105,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1105,
21,
29118
],
[
29118,
60,
530
]
],
[
[
1105,
63,
701
],
[
701,... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Trihexyphenidyl (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Dronabinol (Compound)
Trihexyphenidyl may cause a modera... |
DB00055 | DB09068 | 834 | 1,427 | [
"DDInter605",
"DDInter1948"
] | Drotrecogin alfa | Vortioxetine | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
834,
24,
1427
]
],
[
[
834,
64,
25
],
[
25,
24,
1427
]
],
[
[
834,
25,
256
],
[
256,
24,
1427
]
],
[
[
834,
25,
405
],
[
405,
63... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Drotrecogin alfa may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause... |
DB00468 | DB01059 | 1,424 | 956 | [
"DDInter1557",
"DDInter1313"
] | Quinine | Norfloxacin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
1424,
24,
956
]
],
[
[
1424,
24,
872
],
[
872,
40,
956
]
],
[
[
1424,
64,
1176
],
[
1176,
1,
956
]
],
[
[
1424,
24,
1539
],
[
1539,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Quinine may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Quinine may... |
DB00681 | DB01324 | 1,287 | 178 | [
"DDInter85",
"DDInter1490"
] | Amphotericin B | Polythiazide | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
1287,
24,
178
]
],
[
[
1287,
24,
674
],
[
674,
40,
178
]
],
[
[
1287,
63,
1014
],
[
1014,
40,
178
]
],
[
[
1287,
21,
28835
],
[
28835,... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazid... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) re... |
DB00206 | DB06694 | 1,245 | 31 | [
"DDInter1582",
"DDInter1952"
] | Reserpine | Xylometazoline (nasal) | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
1245,
24,
31
]
],
[
[
1245,
24,
1148
],
[
1148,
24,
31
]
],
[
[
1245,
24,
1629
],
[
1629,
63,
31
]
],
[
[
1245,
37,
247
],
[
247,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
... |
DB00431 | DB11943 | 1,503 | 255 | [
"DDInter1072",
"DDInter495"
] | Lindane | Delafloxacin | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1503,
24,
255
]
],
[
[
1503,
63,
1648
],
[
1648,
23,
255
]
],
[
[
1503,
24,
913
],
[
913,
24,
255
]
],
[
[
1503,
25,
593
],
[
593,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutami... |
DB01611 | DB11978 | 1,487 | 124 | [
"DDInter893",
"DDInter822"
] | Hydroxychloroquine | Glasdegib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1487,
25,
124
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
124
]
],
[
[
1487,
63,
112
],
[
112,
23,
124
]
],
[
[
1487,
25,
1079
],
[
1079,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01261 | DB09045 | 170 | 52 | [
"DDInter1679",
"DDInter607"
] | Sitagliptin | Dulaglutide | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Minor | 0 | [
[
[
170,
23,
52
]
],
[
[
170,
62,
1103
],
[
1103,
23,
52
]
],
[
[
170,
24,
280
],
[
280,
24,
52
]
],
[
[
170,
63,
609
],
[
609,
24,
... | [
[
[
"Sitagliptin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dulaglutide"
]
],
[
[
"Sitagliptin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine and Meph... |
DB00158 | DB00205 | 356 | 929 | [
"DDInter771",
"DDInter1550"
] | Folic acid | Pyrimethamine | Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic aci... | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Moderate | 1 | [
[
[
356,
24,
929
]
],
[
[
356,
21,
28709
],
[
28709,
60,
929
]
],
[
[
356,
24,
1548
],
[
1548,
63,
929
]
],
[
[
356,
23,
50
],
[
50,
... | [
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyrimethamine"
]
],
[
[
"Folic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Decreased appetite"
],
[
"Decreased appetite",
"{u} ... | Folic acid (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Pyrimethamine (Compound)
Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim and Trimethoprim may cause a moderate interaction that could exacerbate disease... |
DB01033 | DB05679 | 328 | 1,683 | [
"DDInter1156",
"DDInter1907"
] | Mercaptopurine | Ustekinumab | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
328,
24,
1683
]
],
[
[
328,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
328,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
328,
63,
305
],
[
305,
... | [
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
... | Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Ola... |
DB00470 | DB01018 | 530 | 1,364 | [
"DDInter601",
"DDInter847"
] | Dronabinol | Guanfacine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Moderate | 1 | [
[
[
530,
24,
1364
]
],
[
[
530,
24,
94
],
[
94,
1,
1364
]
],
[
[
530,
6,
10215
],
[
10215,
45,
1364
]
],
[
[
530,
21,
28709
],
[
28709,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanfacine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Guanfacine (Compound)
Dronabinol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Guanfacine (Compound)
Dronabinol (Compound) causes Decreased appetite (Side Effect) ... |
DB01142 | DB01177 | 1,264 | 77 | [
"DDInter593",
"DDInter904"
] | Doxepin | Idarubicin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1264,
24,
77
]
],
[
[
1264,
6,
6017
],
[
6017,
45,
77
]
],
[
[
1264,
7,
6952
],
[
6952,
46,
77
]
],
[
[
1264,
21,
28987
],
[
28987,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Doxepin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Doxepin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound)
Doxepin (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Doxepin may cause a... |
DB00026 | DB08908 | 1,184 | 713 | [
"DDInter94",
"DDInter564"
] | Anakinra | Dimethyl fumarate | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1184,
24,
713
]
],
[
[
1184,
24,
1083
],
[
1083,
24,
713
]
],
[
[
1184,
25,
725
],
[
725,
63,
713
]
],
[
[
1184,
24,
119
],
[
119,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Anakinra may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab... |
DB00877 | DB01362 | 629 | 497 | [
"DDInter1678",
"DDInter960"
] | Sirolimus | Iohexol | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
629,
25,
497
]
],
[
[
629,
25,
258
],
[
258,
40,
497
]
],
[
[
629,
18,
7744
],
[
7744,
57,
497
]
],
[
[
629,
21,
28681
],
[
28681,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Compoun... | Sirolimus may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Sirolimus (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Iohexol (Compound)
Sirolimus (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity... |
DB00208 | DB00289 | 1,018 | 847 | [
"DDInter1804",
"DDInter132"
] | Ticlopidine | Atomoxetine | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Moderate | 1 | [
[
[
1018,
24,
847
]
],
[
[
1018,
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],
[
109,
40,
847
]
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[
[
1018,
24,
126
],
[
126,
1,
847
]
],
[
[
1018,
23,
211
],
[
211,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
[... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Atomoxetine (Compound)
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Atomoxetine (Compound)
... |
DB00486 | DB01224 | 1,614 | 623 | [
"DDInter1253",
"DDInter1553"
] | Nabilone | Quetiapine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1614,
24,
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]
],
[
[
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[
827,
1,
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],
[
[
1614,
63,
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],
[
695,
1,
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]
],
[
[
1614,
21,
28952
],
[
28952,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
"... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Nabilone... |
DB00708 | DB00889 | 1,454 | 1,133 | [
"DDInter1718",
"DDInter840"
] | Sufentanil | Granisetron | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
1454,
25,
1133
]
],
[
[
1454,
63,
19
],
[
19,
40,
1133
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],
[
[
1454,
63,
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[
85,
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],
[
[
1454,
6,
8374
],
[
8374,
... | [
[
[
"Sufentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyam... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Compound)
... |
DB01001 | DB01278 | 688 | 1,021 | [
"DDInter1632",
"DDInter1506"
] | Salbutamol | Pramlintide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
688,
24,
1021
]
],
[
[
688,
63,
1680
],
[
1680,
24,
1021
]
],
[
[
688,
24,
1539
],
[
1539,
24,
1021
]
],
[
[
688,
23,
708
],
[
708,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Etacrynic acid and Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin an... |
DB01136 | DB12130 | 772 | 1,017 | [
"DDInter305",
"DDInter1094"
] | Carvedilol | Lorlatinib | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
772,
24,
1017
]
],
[
[
772,
63,
608
],
[
608,
23,
1017
]
],
[
[
772,
63,
590
],
[
590,
24,
1017
]
],
[
[
772,
24,
976
],
[
976,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohe... |
DB09082 | DB14568 | 659 | 982 | [
"DDInter1934",
"DDInter1000"
] | Vilanterol | Ivosidenib | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
659,
24,
982
]
],
[
[
659,
24,
1032
],
[
1032,
24,
982
]
],
[
[
659,
63,
1559
],
[
1559,
24,
982
]
],
[
[
659,
24,
159
],
[
159,
... | [
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
],
... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Famotidine an... |
DB00358 | DB00759 | 1,010 | 1,620 | [
"DDInter1140",
"DDInter1783"
] | Mefloquine | Tetracycline | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Minor | 0 | [
[
[
1010,
23,
1620
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1620
]
],
[
[
1010,
23,
1311
],
[
1311,
62,
1620
]
],
[
[
1010,
24,
1399
],
[
139... | [
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracycline"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tetracycline (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide and Metoclopramide may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mefloquine... |
DB00445 | DB04868 | 322 | 478 | [
"DDInter655",
"DDInter1293"
] | Epirubicin | Nilotinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
322,
25,
478
]
],
[
[
322,
24,
1468
],
[
1468,
63,
478
]
],
[
[
322,
5,
11555
],
[
11555,
44,
478
]
],
[
[
322,
7,
2692
],
[
2692,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Epirubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib ... |
DB00515 | DB11988 | 589 | 270 | [
"DDInter387",
"DDInter1321"
] | Cisplatin | Ocrelizumab | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
589,
24,
270
]
],
[
[
589,
63,
1461
],
[
1461,
23,
270
]
],
[
[
589,
24,
1060
],
[
1060,
63,
270
]
],
[
[
589,
63,
134
],
[
134,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enf... |
DB12240 | DB12834 | 110 | 148 | [
"DDInter1485",
"DDInter1649"
] | Polatuzumab vedotin | Secnidazole | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
110,
24,
148
]
],
[
[
110,
63,
1593
],
[
1593,
24,
148
]
],
[
[
110,
64,
1510
],
[
1510,
24,
148
]
],
[
[
110,
63,
1593
],
[
1593,
... | [
[
[
"Polatuzumab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Polatuzumab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotin... | Polatuzumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Polatuzumab vedotin may lead to a major life threatening interaction when taken with Teriflunomide and... |
DB00774 | DB11921 | 1,577 | 1,019 | [
"DDInter889",
"DDInter492"
] | Hydroflumethiazide | Deflazacort | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1577,
24,
1019
]
],
[
[
1577,
24,
959
],
[
959,
24,
1019
]
],
[
[
1577,
1,
359
],
[
359,
24,
1019
]
],
[
[
1577,
63,
355
],
[
355,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate... |
DB00024 | DB09043 | 818 | 135 | [
"DDInter1800",
"DDInter36"
] | Thyrotropin alfa | Albiglutide | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
818,
24,
135
]
],
[
[
818,
24,
1647
],
[
1647,
23,
135
]
],
[
[
818,
24,
176
],
[
176,
24,
135
]
],
[
[
818,
24,
1296
],
[
1296,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargi... |
DB00019 | DB00570 | 1,257 | 147 | [
"DDInter1405",
"DDInter1936"
] | Pegfilgrastim | Vinblastine | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
1257,
24,
147
]
],
[
[
1257,
24,
134
],
[
134,
24,
147
]
],
[
[
1257,
24,
970
],
[
970,
23,
147
]
],
[
[
1257,
24,
37
],
[
37,
6... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil... |
DB00005 | DB01265 | 1,057 | 1,477 | [
"DDInter687",
"DDInter1757"
] | Etanercept | Telbivudine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
1057,
24,
1477
]
],
[
[
1057,
25,
1083
],
[
1083,
1,
1477
]
],
[
[
1057,
24,
231
],
[
231,
1,
1477
]
],
[
[
1057,
24,
112
],
[
112,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluridine"
],
[
"Triflur... | Etanercept may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine (Compound) resembles Telbivudine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine (Compound) resembles Telbivudine (Compound)
Etanercept ... |
DB00367 | DB01259 | 566 | 392 | [
"DDInter1061",
"DDInter1024"
] | Levonorgestrel | Lapatinib | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
566,
24,
392
]
],
[
[
566,
18,
2097
],
[
2097,
45,
392
]
],
[
[
566,
6,
8374
],
[
8374,
45,
392
]
],
[
[
566,
18,
10780
],
[
10780,
... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) downregulates {v} (Gene)",
"ERBB2"
],
[
"ERBB2",
"{u} (Gene) is bound by {v}... | Levonorgestrel (Compound) downregulates ERBB2 (Gene) and ERBB2 (Gene) is bound by Lapatinib (Compound)
Levonorgestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Levonorgestrel (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
Levonorgest... |
DB00501 | DB11703 | 752 | 405 | [
"DDInter380",
"DDInter9"
] | Cimetidine | Acalabrutinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
752,
24,
405
]
],
[
[
752,
23,
1384
],
[
1384,
24,
405
]
],
[
[
752,
62,
139
],
[
139,
24,
405
]
],
[
[
752,
24,
951
],
[
951,
2... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Zidovudine and Zidovud... |
DB00912 | DB01110 | 473 | 86 | [
"DDInter1581",
"DDInter1209"
] | Repaglinide | Miconazole | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
473,
24,
86
]
],
[
[
473,
6,
8374
],
[
8374,
45,
86
]
],
[
[
473,
21,
28787
],
[
28787,
60,
86
]
],
[
[
473,
24,
318
],
[
318,
6... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound)
Repaglinide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Miconazole (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram a... |
DB01234 | DB11601 | 1,220 | 1,270 | [
"DDInter513",
"DDInter1889"
] | Dexamethasone | Tuberculin purified protein derivative | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1220,
24,
1270
]
],
[
[
1220,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
1220,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
1220,
1,
1486
],
[
148... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Dexamethasone may lead to a major life threatening interaction when taken with ... |
DB01319 | DB09049 | 34 | 1,135 | [
"DDInter777",
"DDInter1261"
] | Fosamprenavir | Naloxegol | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
34,
25,
1135
]
],
[
[
34,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
34,
24,
971
],
[
971,
62,
1135
]
],
[
[
34,
63,
1424
],
[
1424,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
],
[
"Neratinib",
"{u... | Fosamprenavir may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may c... |
DB00539 | DB00836 | 11 | 543 | [
"DDInter1837",
"DDInter1088"
] | Toremifene | Loperamide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
11,
35,
543
]
],
[
[
11,
36,
675
],
[
675,
24,
543
]
],
[
[
11,
1,
649
],
[
649,
1,
543
]
],
[
[
11,
64,
1300
],
[
1300,
24,
... | [
[
[
"Toremifene",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Toremifene",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threate... | Toremifene (Compound) resembles Loperamide (Compound) and
Toremifene (Compound) resembles Dextropropoxyphene (Compound) and Toremifene may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00792 | DB05381 | 832 | 172 | [
"DDInter1878",
"DDInter863"
] | Tripelennamine | Histamine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
832,
24,
172
]
],
[
[
832,
24,
1264
],
[
1264,
24,
172
]
],
[
[
832,
63,
1242
],
[
1242,
24,
172
]
],
[
[
832,
24,
337
],
[
337,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetir... |
DB11901 | DB12147 | 913 | 241 | [
"DDInter107",
"DDInter661"
] | Apalutamide | Erdafitinib | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Major | 2 | [
[
[
913,
25,
241
]
],
[
[
913,
63,
170
],
[
170,
24,
241
]
],
[
[
913,
64,
1456
],
[
1456,
24,
241
]
],
[
[
913,
25,
982
],
[
982,
6... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erdafitinib"
]
],
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
"Sitagl... | Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Apalutamide may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may c... |
DB01255 | DB09080 | 633 | 144 | [
"DDInter1078",
"DDInter1331"
] | Lisdexamfetamine | Olodaterol | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
633,
24,
144
]
],
[
[
633,
25,
1011
],
[
1011,
24,
144
]
],
[
[
633,
64,
11
],
[
11,
24,
144
]
],
[
[
633,
63,
543
],
[
543,
24,... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Lisdexamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
... | Lisdexamfetamine may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Lisdexamfetamine may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a m... |
DB11130 | DB11632 | 407 | 580 | [
"DDInter1344",
"DDInter1343"
] | Opium | Opicapone | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
407,
24,
580
]
],
[
[
407,
63,
104
],
[
104,
24,
580
]
],
[
[
407,
24,
1609
],
[
1609,
24,
580
]
],
[
[
407,
64,
1053
],
[
1053,
... | [
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Opium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
"Meth... | Opium may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Opium may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyver... |
DB00986 | DB01102 | 1,192 | 1,188 | [
"DDInter834",
"DDInter114"
] | Glycopyrronium | Arbutamine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately . | Moderate | 1 | [
[
[
1192,
24,
1188
]
],
[
[
1192,
63,
1523
],
[
1523,
40,
1188
]
],
[
[
1192,
63,
1507
],
[
1507,
24,
1188
]
],
[
[
1192,
24,
1511
],
[
15... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arbutamine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Arbutamine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction th... |
DB00357 | DB01238 | 1,051 | 673 | [
"DDInter71",
"DDInter118"
] | Aminoglutethimide | Aripiprazole | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
1051,
24,
673
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
673
]
],
[
[
1051,
21,
29209
],
[
29209,
60,
673
]
],
[
[
1051,
24,
1424
],
[
1424... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by ... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aripiprazole (Compound)
Aminoglutethimide (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Aripiprazole (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00675 | DB05812 | 888 | 1,374 | [
"DDInter1744",
"DDInter8"
] | Tamoxifen | Abiraterone | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Major | 2 | [
[
[
888,
25,
1374
]
],
[
[
888,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
888,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
888,
23,
112
],
[
112,... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
]
],
[
[
"Tamoxifen",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Abirater... | Tamoxifen (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Tamoxifen (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Tamoxifen may cause a minor interaction that can limit clinical effects when taken... |
DB00439 | DB00501 | 289 | 752 | [
"DDInter341",
"DDInter380"
] | Cerivastatin | Cimetidine | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
289,
24,
752
]
],
[
[
289,
24,
112
],
[
112,
62,
752
]
],
[
[
289,
25,
609
],
[
609,
62,
752
]
],
[
[
289,
24,
629
],
[
629,
63,... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Cerivastatin may lead to a major life threatening interaction when taken with Clarithromycin and Clarithro... |
DB00307 | DB09048 | 1,101 | 555 | [
"DDInter202",
"DDInter1284"
] | Bexarotene | Netupitant | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Minor | 0 | [
[
[
1101,
23,
555
]
],
[
[
1101,
24,
466
],
[
466,
62,
555
]
],
[
[
1101,
23,
760
],
[
760,
62,
555
]
],
[
[
1101,
24,
254
],
[
254,
... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Netupitant"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Netupitant
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat and Cobici... |
DB00451 | DB00658 | 542 | 965 | [
"DDInter1064",
"DDInter1663"
] | Levothyroxine | Sevelamer | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | Moderate | 1 | [
[
[
542,
24,
965
]
],
[
[
542,
21,
28787
],
[
28787,
60,
965
]
],
[
[
542,
40,
1152
],
[
1152,
24,
965
]
],
[
[
542,
40,
624
],
[
624,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevelamer"
]
],
[
[
"Levothyroxine",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) ... | Levothyroxine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Sevelamer (Compound)
Levothyroxine (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Sevelamer
Levothyroxine (Compound) resembles... |
DB00927 | DB09082 | 1,559 | 659 | [
"DDInter712",
"DDInter1934"
] | Famotidine | Vilanterol | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1559,
24,
659
]
],
[
[
1559,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1559,
24,
927
],
[
927,
63,
659
]
],
[
[
1559,
24,
1069
],
[
1069,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and E... |
DB01211 | DB06702 | 609 | 573 | [
"DDInter393",
"DDInter731"
] | Clarithromycin | Fesoterodine | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Major | 2 | [
[
[
609,
25,
573
]
],
[
[
609,
63,
211
],
[
211,
1,
573
]
],
[
[
609,
64,
494
],
[
494,
1,
573
]
],
[
[
609,
6,
8374
],
[
8374,
45,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fesoterodine"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Clarithromycin may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (Compoun... |
DB00526 | DB05316 | 1,555 | 749 | [
"DDInter1355",
"DDInter1467"
] | Oxaliplatin | Pimavanserin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
1555,
24,
749
]
],
[
[
1555,
24,
112
],
[
112,
23,
749
]
],
[
[
1555,
24,
522
],
[
522,
24,
749
]
],
[
[
1555,
63,
521
],
[
521,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast a... |
DB00641 | DB09036 | 467 | 812 | [
"DDInter1675",
"DDInter1668"
] | Simvastatin | Siltuximab | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
467,
24,
812
]
],
[
[
467,
74,
1463
],
[
1463,
24,
812
]
],
[
[
467,
25,
33
],
[
33,
24,
812
]
],
[
[
467,
63,
147
],
[
147,
24,... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Simvastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken... | Simvastatin (Compound) resembles Lovastatin (Compound) and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Simvastatin may lead to a major life threatening int... |
DB05679 | DB15719 | 1,683 | 487 | [
"DDInter1907",
"DDInter171"
] | Ustekinumab | Belantamab mafodotin | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
1683,
24,
487
]
],
[
[
1683,
24,
259
],
[
259,
24,
487
]
],
[
[
1683,
63,
4
],
[
4,
24,
487
]
],
[
[
1683,
25,
976
],
[
976,
25,... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxi... |
DB00959 | DB11627 | 1,486 | 1,367 | [
"DDInter1191",
"DDInter860"
] | Methylprednisolone | Hepatitis B Vaccine (Recombinant) | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1486,
24,
1367
]
],
[
[
1486,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
1486,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
1486,
24,
259
],
[
259... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Methylprednisolone may lead to a major life threatening interaction when taken ... |
DB00176 | DB06691 | 529 | 849 | [
"DDInter770",
"DDInter1155"
] | Fluvoxamine | Mepyramine | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
529,
24,
849
]
],
[
[
529,
24,
1594
],
[
1594,
24,
849
]
],
[
[
529,
6,
12523
],
[
12523,
45,
849
]
],
[
[
529,
63,
1648
],
[
1648,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Fluvoxamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Fluvoxamine may ... |
DB00041 | DB00220 | 1,648 | 798 | [
"DDInter38",
"DDInter1276"
] | Aldesleukin | Nelfinavir | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Moderate | 1 | [
[
[
1648,
24,
798
]
],
[
[
1648,
24,
215
],
[
215,
40,
798
]
],
[
[
1648,
24,
1327
],
[
1327,
1,
798
]
],
[
[
1648,
24,
1532
],
[
1532,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indinavir"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Indinavir and Indinavir (Compound) resembles Nelfinavir (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Nelfinavir (Compound)
... |
DB00675 | DB00831 | 888 | 1,178 | [
"DDInter1744",
"DDInter1866"
] | Tamoxifen | Trifluoperazine | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
888,
24,
1178
]
],
[
[
888,
64,
695
],
[
695,
40,
1178
]
],
[
[
888,
24,
851
],
[
851,
40,
1178
]
],
[
[
888,
24,
9
],
[
9,
1,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Clozapin... | Tamoxifen may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Trifluoperazine (Compound)
Tamoxifen... |
DB00321 | DB11978 | 21 | 124 | [
"DDInter78",
"DDInter822"
] | Amitriptyline | Glasdegib | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
21,
24,
124
]
],
[
[
21,
23,
112
],
[
112,
23,
124
]
],
[
[
21,
63,
475
],
[
475,
24,
124
]
],
[
[
21,
24,
79
],
[
79,
24,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Amitriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Morphine and M... |
DB11952 | DB11986 | 800 | 484 | [
"DDInter612",
"DDInter648"
] | Duvelisib | Entrectinib | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
800,
25,
484
]
],
[
[
800,
23,
466
],
[
466,
62,
484
]
],
[
[
800,
64,
1135
],
[
1135,
23,
484
]
],
[
[
800,
62,
222
],
[
222,
2... | [
[
[
"Duvelisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Duvelisib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
"Darolutamid... | Duvelisib may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Duvelisib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a m... |
DB00983 | DB01367 | 480 | 1,163 | [
"DDInter776",
"DDInter1572"
] | Formoterol | Rasagiline | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
480,
24,
1163
]
],
[
[
480,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
480,
24,
1520
],
[
1520,
24,
1163
]
],
[
[
480,
63,
1445
],
[
1445... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Formoterol",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused... | Formoterol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Rasagilin... |
DB00652 | DB01191 | 234 | 1,039 | [
"DDInter1421",
"DDInter518"
] | Pentazocine | Dexfenfluramine | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
234,
25,
1039
]
],
[
[
234,
24,
578
],
[
578,
63,
1039
]
],
[
[
234,
63,
1503
],
[
1503,
24,
1039
]
],
[
[
234,
24,
1347
],
[
1347,
... | [
[
[
"Pentazocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Tic... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Lindane and Li... |
DB01253 | DB06706 | 628 | 468 | [
"DDInter664",
"DDInter985"
] | Ergometrine | Isometheptene | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Major | 2 | [
[
[
628,
25,
468
]
],
[
[
628,
6,
5214
],
[
5214,
45,
468
]
],
[
[
628,
64,
1466
],
[
1466,
24,
468
]
],
[
[
628,
1,
1131
],
[
1131,
... | [
[
[
"Ergometrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isometheptene"
]
],
[
[
"Ergometrine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)",
"Is... | Ergometrine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Isometheptene (Compound)
Ergometrine may lead to a major life threatening interaction when taken with Phenylpropanolamine and Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Ergomet... |
DB00572 | DB01224 | 85 | 623 | [
"DDInter136",
"DDInter1553"
] | Atropine | Quetiapine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
85,
24,
623
]
],
[
[
85,
63,
695
],
[
695,
1,
623
]
],
[
[
85,
24,
1178
],
[
1178,
1,
623
]
],
[
[
85,
6,
7992
],
[
7992,
45,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
"... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Quetiapine (Compou... |
DB00471 | DB00582 | 201 | 1,622 | [
"DDInter1242",
"DDInter1946"
] | Montelukast | Voriconazole | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
201,
24,
1622
]
],
[
[
201,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
201,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
201,
24,
112
],
[
112,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Montelukast (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Metronidaz... |
DB01254 | DB14409 | 1,213 | 1,129 | [
"DDInter484",
"DDInter867"
] | Dasatinib | Human adenovirus e serotype 4 strain cl-68578 antigen | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1213,
24,
1129
]
],
[
[
1213,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1213,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
1213,
63,
147
],
[
147... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"E... | Dasatinib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00595 | DB00808 | 1,545 | 1,605 | [
"DDInter1374",
"DDInter916"
] | Oxytetracycline | Indapamide | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Minor | 0 | [
[
[
1545,
23,
1605
]
],
[
[
1545,
62,
811
],
[
811,
1,
1605
]
],
[
[
1545,
40,
1669
],
[
1669,
62,
1605
]
],
[
[
1545,
40,
964
],
[
964,
... | [
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
],
... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Oxytetracycline (Compound) resembles Minocycline (Compound) and Minocycline may cause a minor interaction that can limit clinical effects when taken with Ind... |
DB00424 | DB01235 | 19 | 1,191 | [
"DDInter896",
"DDInter1054"
] | Hyoscyamine | Levodopa | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
19,
24,
1191
]
],
[
[
19,
10,
11558
],
[
11558,
49,
1191
]
],
[
[
19,
21,
28936
],
[
28936,
60,
1191
]
],
[
[
19,
24,
1264
],
[
1264,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Hyoscyamine",
"{u} (Compound) palliates {v} (Disease)",
"Parkinson's disease"
],
[
"Parkinson's disease",
"{u} (D... | Hyoscyamine (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Levodopa (Compound)
Hyoscyamine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Levodopa (Compound)
Hyoscyamine may cause a moderate interaction that could exacerba... |
DB00687 | DB08938 | 870 | 1,384 | [
"DDInter747",
"DDInter1112"
] | Fludrocortisone | Magaldrate | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
870,
23,
1384
]
],
[
[
870,
1,
167
],
[
167,
23,
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[
[
870,
24,
1178
],
[
1178,
23,
1384
]
],
[
[
870,
63,
461
],
[
461,
... | [
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Hydrocortisone"
],
[
"Hydrocortisone",
"{u} may... | Fludrocortisone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine may cause a minor... |
DB00074 | DB06674 | 1,309 | 908 | [
"DDInter166",
"DDInter837"
] | Basiliximab | Golimumab | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1309,
25,
908
]
],
[
[
1309,
23,
1193
],
[
1193,
62,
908
]
],
[
[
1309,
23,
1461
],
[
1461,
23,
908
]
],
[
[
1309,
24,
200
],
[
200,
... | [
[
[
"Basiliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Basiliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gl... | Basiliximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Basiliximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB00675 | DB04953 | 888 | 495 | [
"DDInter1744",
"DDInter708"
] | Tamoxifen | Ezogabine | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
888,
24,
495
]
],
[
[
888,
6,
8717
],
[
8717,
45,
495
]
],
[
[
888,
21,
28787
],
[
28787,
60,
495
]
],
[
[
888,
23,
1135
],
[
1135,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Tamoxifen",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",
... | Tamoxifen (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Ezogabine (Compound)
Tamoxifen (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ezogabine (Compound)
Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol ... |
DB00454 | DB09241 | 1,349 | 1,629 | [
"DDInter1150",
"DDInter1186"
] | Meperidine | Methylene blue | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1349,
25,
1629
]
],
[
[
1349,
24,
1311
],
[
1311,
24,
1629
]
],
[
[
1349,
63,
73
],
[
73,
25,
1629
]
],
[
[
1349,
40,
411
],
[
411,
... | [
[
[
"Meperidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"Me... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Phentermi... |
DB00544 | DB00916 | 970 | 112 | [
"DDInter757",
"DDInter1202"
] | Fluorouracil | Metronidazole | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
970,
24,
112
]
],
[
[
970,
24,
458
],
[
458,
40,
112
]
],
[
[
970,
6,
3486
],
[
3486,
45,
112
]
],
[
[
970,
21,
29028
],
[
29028,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Fluorouracil (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Fluorouracil (Compound) causes Encephalopathy (Side Effe... |
DB00526 | DB14783 | 1,555 | 287 | [
"DDInter1355",
"DDInter574"
] | Oxaliplatin | Diroximel fumarate | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1555,
24,
287
]
],
[
[
1555,
63,
1560
],
[
1560,
24,
287
]
],
[
[
1555,
24,
384
],
[
384,
24,
287
]
],
[
[
1555,
25,
478
],
[
478,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegaspargase"
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Idelali... |
DB00912 | DB09381 | 473 | 192 | [
"DDInter1581",
"DDInter678"
] | Repaglinide | Esterified estrogens | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
473,
24,
192
]
],
[
[
473,
63,
752
],
[
752,
23,
192
]
],
[
[
473,
24,
1019
],
[
1019,
63,
192
]
],
[
[
473,
24,
5
],
[
5,
24,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort... |
DB00408 | DB01181 | 1,408 | 1,532 | [
"DDInter1099",
"DDInter906"
] | Loxapine | Ifosfamide | An antipsychotic agent used in schizophrenia. [PubChem] | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1408,
24,
1532
]
],
[
[
1408,
21,
28695
],
[
28695,
60,
1532
]
],
[
[
1408,
24,
401
],
[
401,
24,
1532
]
],
[
[
1408,
35,
13
],
[
13,
... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Loxapine",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspnoea"
],
[
"Dyspnoea",
"{u} (Side Effect) is caused by ... | Loxapine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Ifosfamide (Compound)
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamid... |
DB09122 | DB11363 | 1,613 | 1,276 | [
"DDInter1409",
"DDInter39"
] | Peginterferon beta-1a | Alectinib | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
1613,
24,
1276
]
],
[
[
1613,
63,
305
],
[
305,
24,
1276
]
],
[
[
1613,
24,
242
],
[
242,
63,
1276
]
],
[
[
1613,
64,
1510
],
[
1510,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aspara... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Peginterferon beta-1a may cause a moderate interaction that coul... |
DB00561 | DB09268 | 1,048 | 1,662 | [
"DDInter591",
"DDInter1464"
] | Doxapram | Picosulfuric acid | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1048,
24,
1662
]
],
[
[
1048,
63,
1466
],
[
1466,
24,
1662
]
],
[
[
1048,
40,
998
],
[
998,
24,
1662
]
],
[
[
1048,
64,
534
],
[
534,
... | [
[
[
"Doxapram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Doxapram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylpropanolamine"
... | Doxapram may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamine and Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Doxapram (Compound) resembles Phenylbutazone (Compound) and Phenylbutazone may cause a mo... |
DB09389 | DB12010 | 517 | 214 | [
"DDInter1315",
"DDInter785"
] | Norgestrel | Fostamatinib | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
517,
24,
214
]
],
[
[
517,
63,
723
],
[
723,
24,
214
]
],
[
[
517,
62,
1130
],
[
1130,
24,
214
]
],
[
[
517,
24,
1017
],
[
1017,
... | [
[
[
"Norgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Norgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Norgestrel may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Norgestrel may cause a minor interaction that can limit clinical effects when taken with Pioglitazone and Piog... |
DB08881 | DB09472 | 868 | 1,383 | [
"DDInter1925",
"DDInter1693"
] | Vemurafenib | Sodium sulfate | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
868,
24,
1383
]
],
[
[
868,
63,
1252
],
[
1252,
23,
1383
]
],
[
[
868,
64,
609
],
[
609,
24,
1383
]
],
[
[
868,
63,
1405
],
[
1405,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Vemurafenib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may ... |
DB00995 | DB05679 | 1,112 | 1,683 | [
"DDInter139",
"DDInter1907"
] | Auranofin | Ustekinumab | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1112,
24,
1683
]
],
[
[
1112,
24,
309
],
[
309,
24,
1683
]
],
[
[
1112,
24,
36
],
[
36,
63,
1683
]
],
[
[
1112,
63,
589
],
[
589,
... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribuli... |
DB00661 | DB01254 | 122 | 1,213 | [
"DDInter1928",
"DDInter484"
] | Verapamil | Dasatinib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
122,
24,
1213
]
],
[
[
122,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
122,
7,
15855
],
[
15855,
46,
1213
]
],
[
[
122,
21,
28956
],
[
289... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Verapamil (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Verapamil (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Dasatinib (Compound)
Verapamil (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dasatinib (Compound)
Verapami... |
DB08946 | DB09135 | 512 | 1,211 | [
"DDInter962",
"DDInter967"
] | Iopanoic acid | Ioxilan | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
512,
24,
1211
]
],
[
[
512,
63,
17
],
[
17,
24,
1211
]
],
[
[
512,
63,
17
],
[
17,
1,
88
],
[
88,
24,
1211
]
],
[
[
512,
63,
... | [
[
[
"Iopanoic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Iopanoic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
],
[
... | Iopanoic acid may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Iopanoic acid may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Com... |
DB00321 | DB09472 | 21 | 1,383 | [
"DDInter78",
"DDInter1693"
] | Amitriptyline | Sodium sulfate | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
21,
24,
1383
]
],
[
[
21,
24,
609
],
[
609,
24,
1383
]
],
[
[
21,
1,
1405
],
[
1405,
24,
1383
]
],
[
[
21,
63,
521
],
[
521,
24,... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Amitriptyline (Compound) resembles Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a mod... |
DB00604 | DB00656 | 1,425 | 827 | [
"DDInter385",
"DDInter1851"
] | Cisapride | Trazodone | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Major | 2 | [
[
[
1425,
25,
827
]
],
[
[
1425,
25,
623
],
[
623,
40,
827
]
],
[
[
1425,
25,
1630
],
[
1630,
1,
827
]
],
[
[
1425,
24,
673
],
[
673,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trazodone"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quetiapine"
],
[
"Quetiapine",
"{u} (Com... | Cisapride may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Cisapride may lead to a major life threatening interaction when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compound)
Cisapride may cause a moderate... |
DB00331 | DB01009 | 1,645 | 935 | [
"DDInter1164",
"DDInter1009"
] | Metformin | Ketoprofen | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1645,
24,
935
]
],
[
[
1645,
24,
1274
],
[
1274,
24,
935
]
],
[
[
1645,
24,
1263
],
[
1263,
1,
935
]
],
[
[
1645,
18,
7359
],
[
7359,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromf... |
DB00476 | DB00927 | 109 | 1,559 | [
"DDInter608",
"DDInter712"
] | Duloxetine | Famotidine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Minor | 0 | [
[
[
109,
23,
1559
]
],
[
[
109,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
109,
23,
1384
],
[
1384,
62,
1559
]
],
[
[
109,
24,
1274
],
[
1274... | [
[
[
"Duloxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Famotidine"
]
],
[
[
"Duloxetine",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is caused b... | Duloxetine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a minor interaction that can limit clinical effects when taken with Famotidine
Du... |
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