drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01610 | DB06704 | 248 | 247 | [
"DDInter1912",
"DDInter952"
] | Valganciclovir | Iobenguane (I-131) | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
248,
24,
247
]
],
[
[
248,
21,
28787
],
[
28787,
60,
247
]
],
[
[
248,
40,
563
],
[
563,
24,
247
]
],
[
[
248,
24,
810
],
[
810,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Valganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effec... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Valganciclovir (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Valganciclovir (Compound) resembles Ganciclovir (Compound) and Ganciclovir may cause a moder... |
DB00749 | DB09268 | 59 | 1,662 | [
"DDInter699",
"DDInter1464"
] | Etodolac | Picosulfuric acid | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
59,
24,
1662
]
],
[
[
59,
23,
16
],
[
16,
23,
1662
]
],
[
[
59,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
59,
63,
91
],
[
91,
24,
... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Etodolac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
],
[
... | Etodolac may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Etodolac may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may c... |
DB09237 | DB12141 | 1,586 | 971 | [
"DDInter1045",
"DDInter817"
] | Levamlodipine | Gilteritinib | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1586,
24,
971
]
],
[
[
1586,
23,
466
],
[
466,
62,
971
]
],
[
[
1586,
63,
820
],
[
820,
24,
971
]
],
[
[
1586,
24,
283
],
[
283,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Levamlodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
... | Levamlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine a... |
DB00582 | DB12941 | 1,622 | 466 | [
"DDInter1946",
"DDInter481"
] | Voriconazole | Darolutamide | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
1622,
23,
466
]
],
[
[
1622,
24,
1374
],
[
1374,
23,
466
]
],
[
[
1622,
74,
600
],
[
600,
23,
466
]
],
[
[
1622,
25,
351
],
[
351,
... | [
[
[
"Voriconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Voriconazole (Compound) resembles Fluconazole (Compound) and Voriconazole may cause a moderate interaction t... |
DB00031 | DB01381 | 20 | 958 | [
"DDInter1764",
"DDInter819"
] | Tenecteplase | Ginkgo biloba | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
20,
24,
958
]
],
[
[
20,
24,
1347
],
[
1347,
24,
958
]
],
[
[
20,
25,
126
],
[
126,
24,
958
]
],
[
[
20,
25,
792
],
[
792,
63,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Tenecteplase may lead to a major life threatening interaction when taken with Warfarin and Warfarin may c... |
DB00289 | DB01064 | 847 | 1,148 | [
"DDInter132",
"DDInter987"
] | Atomoxetine | Isoprenaline | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
847,
24,
1148
]
],
[
[
847,
24,
1636
],
[
1636,
24,
1148
]
],
[
[
847,
18,
1954
],
[
1954,
57,
1148
]
],
[
[
847,
21,
28717
],
[
28717... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Atomoxetine (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Isoprenaline (Comp... |
DB00580 | DB01234 | 311 | 1,220 | [
"DDInter1910",
"DDInter513"
] | Valdecoxib | Dexamethasone | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
311,
24,
1220
]
],
[
[
311,
24,
870
],
[
870,
1,
1220
]
],
[
[
311,
24,
175
],
[
175,
40,
1220
]
],
[
[
311,
63,
251
],
[
251,
1... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00224 | DB01410 | 215 | 423 | [
"DDInter917",
"DDInter375"
] | Indinavir | Ciclesonide | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Moderate | 1 | [
[
[
215,
24,
423
]
],
[
[
215,
24,
1573
],
[
1573,
1,
423
]
],
[
[
215,
63,
1351
],
[
1351,
40,
423
]
],
[
[
215,
25,
1486
],
[
1486,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compound... |
DB00456 | DB01024 | 164 | 1,096 | [
"DDInter311",
"DDInter1252"
] | Cefalotin | Mycophenolic acid | Cefalotin is a cephalosporin antibiotic. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
164,
24,
1096
]
],
[
[
164,
7,
4634
],
[
4634,
46,
1096
]
],
[
[
164,
18,
20046
],
[
20046,
46,
1096
]
],
[
[
164,
18,
2697
],
[
2697,... | [
[
[
"Cefalotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Cefalotin",
"{u} (Compound) upregulates {v} (Gene)",
"FOXO4"
],
[
"FOXO4",
"{u} (Gene) is upregulated by {... | Cefalotin (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Mycophenolic acid (Compound)
Cefalotin (Compound) downregulates SPAG7 (Gene) and SPAG7 (Gene) is upregulated by Mycophenolic acid (Compound)
Cefalotin (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Mycophenolic ... |
DB04844 | DB11110 | 843 | 603 | [
"DDInter1778",
"DDInter1115"
] | Tetrabenazine | Magnesium citrate | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
843,
24,
603
]
],
[
[
843,
64,
57
],
[
57,
24,
603
]
],
[
[
843,
24,
1616
],
[
1616,
24,
603
]
],
[
[
843,
63,
1151
],
[
1151,
2... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Tetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
... | Tetrabenazine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin a... |
DB00471 | DB01259 | 201 | 392 | [
"DDInter1242",
"DDInter1024"
] | Montelukast | Lapatinib | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
201,
24,
392
]
],
[
[
201,
6,
8374
],
[
8374,
45,
392
]
],
[
[
201,
21,
29429
],
[
29429,
60,
392
]
],
[
[
201,
24,
112
],
[
112,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Montelukast (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Metron... |
DB11828 | DB14840 | 1,406 | 861 | [
"DDInter1281",
"DDInter1601"
] | Neratinib | Ripretinib | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1406,
24,
861
]
],
[
[
1406,
64,
351
],
[
351,
24,
861
]
],
[
[
1406,
63,
1456
],
[
1456,
24,
861
]
],
[
[
1406,
25,
1017
],
[
1017,
... | [
[
[
"Neratinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Neratinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",... | Neratinib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Neratinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoclax may cause a ... |
DB01209 | DB04843 | 1,359 | 1,511 | [
"DDInter531",
"DDInter1149"
] | Dezocine | Mepenzolate | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1359,
24,
1511
]
],
[
[
1359,
63,
1192
],
[
1192,
24,
1511
]
],
[
[
1359,
64,
475
],
[
475,
24,
1511
]
],
[
[
1359,
24,
849
],
[
849,
... | [
[
[
"Dezocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Dezocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
[
... | Dezocine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Dezocine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause... |
DB00395 | DB08899 | 210 | 129 | [
"DDInter301",
"DDInter649"
] | Carisoprodol | Enzalutamide | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
210,
24,
129
]
],
[
[
210,
6,
10215
],
[
10215,
45,
129
]
],
[
[
210,
21,
28921
],
[
28921,
60,
129
]
],
[
[
210,
24,
1532
],
[
1532,
... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Carisoprodol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Com... | Carisoprodol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Enzalutamide (Compound)
Carisoprodol (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Enzalutamide (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Ifosfam... |
DB01172 | DB04834 | 416 | 276 | [
"DDInter1004",
"DDInter1571"
] | Kanamycin | Rapacuronium | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Major | 2 | [
[
[
416,
25,
276
]
],
[
[
416,
63,
91
],
[
91,
24,
276
]
],
[
[
416,
64,
1441
],
[
1441,
24,
276
]
],
[
[
416,
62,
608
],
[
608,
24,... | [
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rapacuronium"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vancomycin... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Kanamycin may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin may cause ... |
DB01097 | DB06663 | 1,377 | 1,154 | [
"DDInter1033",
"DDInter1398"
] | Leflunomide | Pasireotide | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1377,
25,
1154
]
],
[
[
1377,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1377,
63,
112
],
[
112,
23,
1154
]
],
[
[
1377,
64,
663
],
[
663... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused... | Leflunomide (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when t... |
DB01143 | DB04948 | 923 | 1,084 | [
"DDInter65",
"DDInter1083"
] | Amifostine | Lofexidine | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
923,
24,
1084
]
],
[
[
923,
63,
1020
],
[
1020,
1,
1084
]
],
[
[
923,
63,
274
],
[
274,
24,
1084
]
],
[
[
923,
24,
885
],
[
885,
... | [
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
... | Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Lofexidine (Compound)
Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a moderate interaction that cou... |
DB00995 | DB09570 | 1,112 | 1,480 | [
"DDInter139",
"DDInter1002"
] | Auranofin | Ixazomib | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1112,
24,
1480
]
],
[
[
1112,
63,
268
],
[
268,
24,
1480
]
],
[
[
1112,
24,
148
],
[
148,
63,
1480
]
],
[
[
1112,
24,
310
],
[
310,
... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],
... | Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Sec... |
DB00283 | DB06016 | 701 | 1,508 | [
"DDInter395",
"DDInter300"
] | Clemastine | Cariprazine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
701,
24,
1508
]
],
[
[
701,
35,
1242
],
[
1242,
24,
1508
]
],
[
[
701,
24,
1507
],
[
1507,
24,
1508
]
],
[
[
701,
24,
849
],
[
849,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken ... | Clemastine (Compound) resembles Cetirizine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Clemastine may cause a moderate interaction that coul... |
DB09143 | DB15328 | 313 | 829 | [
"DDInter1701",
"DDInter1896"
] | Sonidegib | Ubrogepant | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
313,
24,
829
]
],
[
[
313,
63,
578
],
[
578,
24,
829
]
],
[
[
313,
64,
1593
],
[
1593,
24,
829
]
],
[
[
313,
24,
484
],
[
484,
2... | [
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Sonidegib may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Sonidegib may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a ... |
DB00349 | DB00470 | 902 | 530 | [
"DDInter401",
"DDInter601"
] | Clobazam | Dronabinol | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
902,
24,
530
]
],
[
[
902,
24,
1614
],
[
1614,
40,
530
]
],
[
[
902,
6,
4973
],
[
4973,
45,
530
]
],
[
[
902,
21,
28921
],
[
28921,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
"N... | Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Clobazam (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dronabinol (Compound)
Clobazam (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effec... |
DB00327 | DB01156 | 421 | 593 | [
"DDInter890",
"DDInter252"
] | Hydromorphone | Bupropion | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
421,
25,
593
]
],
[
[
421,
6,
8374
],
[
8374,
45,
593
]
],
[
[
421,
21,
29220
],
[
29220,
60,
593
]
],
[
[
421,
24,
256
],
[
256,
... | [
[
[
"Hydromorphone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Hydromorphone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bu... | Hydromorphone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Hydromorphone (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Bupropion (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when t... |
DB01105 | DB06016 | 222 | 1,508 | [
"DDInter1665",
"DDInter300"
] | Sibutramine | Cariprazine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
222,
24,
1508
]
],
[
[
222,
63,
1242
],
[
1242,
24,
1508
]
],
[
[
222,
62,
600
],
[
600,
24,
1508
]
],
[
[
222,
24,
1213
],
[
1213,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Sibutramine may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluc... |
DB11581 | DB11791 | 1,456 | 785 | [
"DDInter1926",
"DDInter287"
] | Venetoclax | Capmatinib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Major | 2 | [
[
[
1456,
25,
785
]
],
[
[
1456,
62,
1135
],
[
1135,
23,
785
]
],
[
[
1456,
63,
1324
],
[
1324,
24,
785
]
],
[
[
1456,
64,
868
],
[
868,
... | [
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Capmatinib"
]
],
[
[
"Venetoclax",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Venetoclax may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Capmatinib
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazo... |
DB00981 | DB01142 | 1,528 | 1,264 | [
"DDInter1462",
"DDInter593"
] | Physostigmine | Doxepin | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1528,
24,
1264
]
],
[
[
1528,
63,
508
],
[
508,
24,
1264
]
],
[
[
1528,
24,
401
],
[
401,
24,
1264
]
],
[
[
1528,
63,
1405
],
[
1405,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Pro... |
DB00387 | DB11186 | 1,386 | 1,609 | [
"DDInter1528",
"DDInter1427"
] | Procyclidine | Pentoxyverine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1386,
24,
1609
]
],
[
[
1386,
24,
104
],
[
104,
24,
1609
]
],
[
[
1386,
63,
999
],
[
999,
24,
1609
]
],
[
[
1386,
40,
456
],
[
456,
... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpe... |
DB00531 | DB01004 | 450 | 563 | [
"DDInter456",
"DDInter806"
] | Cyclophosphamide | Ganciclovir | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
450,
24,
563
]
],
[
[
450,
24,
248
],
[
248,
40,
563
]
],
[
[
450,
21,
29169
],
[
29169,
60,
563
]
],
[
[
450,
63,
552
],
[
552,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Cyclophosphamide (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Ganciclovir (Compound)
Cyclophosphamide may cau... |
DB00261 | DB11837 | 702 | 1,297 | [
"DDInter93",
"DDInter1351"
] | Anagrelide | Osilodrostat | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
702,
25,
1297
]
],
[
[
702,
23,
112
],
[
112,
23,
1297
]
],
[
[
702,
24,
222
],
[
222,
23,
1297
]
],
[
[
702,
24,
1288
],
[
1288,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Anagrelide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and S... |
DB00214 | DB00938 | 1,028 | 455 | [
"DDInter1836",
"DDInter1635"
] | Torasemide | Salmeterol | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1028,
24,
455
]
],
[
[
1028,
24,
688
],
[
688,
63,
455
]
],
[
[
1028,
6,
3486
],
[
3486,
45,
455
]
],
[
[
1028,
18,
2976
],
[
2976,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Torasemide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Salmeterol (Compound)
Torasemide (Compou... |
DB00230 | DB00902 | 784 | 104 | [
"DDInter1516",
"DDInter1168"
] | Pregabalin | Methdilazine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
784,
24,
104
]
],
[
[
784,
24,
13
],
[
13,
24,
104
]
],
[
[
784,
24,
820
],
[
820,
1,
104
]
],
[
[
784,
24,
537
],
[
537,
40,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB00790 | DB00902 | 664 | 104 | [
"DDInter1431",
"DDInter1168"
] | Perindopril | Methdilazine | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
664,
24,
104
]
],
[
[
664,
24,
820
],
[
820,
1,
104
]
],
[
[
664,
24,
401
],
[
401,
63,
104
]
],
[
[
664,
23,
286
],
[
286,
62,
... | [
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction ... |
DB00242 | DB00290 | 1,064 | 329 | [
"DDInter392",
"DDInter219"
] | Cladribine | Bleomycin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Major | 2 | [
[
[
1064,
25,
329
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
329
]
],
[
[
1064,
7,
7335
],
[
7335,
45,
329
]
],
[
[
1064,
21,
28769
],
[
2876... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bleomycin"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated by... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Bleomycin (Compound)
Cladribine (Compound) upregulates LIG1 (Gene) and LIG1 (Gene) is bound by Bleomycin (Compound)
Cladribine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is c... |
DB00358 | DB00867 | 1,010 | 1,052 | [
"DDInter1140",
"DDInter1606"
] | Mefloquine | Ritodrine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Adrenergic beta-agonist used to control premature labor. | Moderate | 1 | [
[
[
1010,
24,
1052
]
],
[
[
1010,
24,
1523
],
[
1523,
40,
1052
]
],
[
[
1010,
18,
2183
],
[
2183,
57,
1052
]
],
[
[
1010,
24,
1220
],
[
12... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ritodrine (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Ritodrine (Compound)
Mefloquine may cause a moderate interaction that could e... |
DB00307 | DB13879 | 1,101 | 1,043 | [
"DDInter202",
"DDInter824"
] | Bexarotene | Glecaprevir | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Moderate | 1 | [
[
[
1101,
24,
1043
]
],
[
[
1101,
24,
1135
],
[
1135,
23,
1043
]
],
[
[
1101,
23,
353
],
[
353,
24,
1043
]
],
[
[
1101,
24,
466
],
[
466,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glecaprevir"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glecaprevir
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Griseofulvin and Griseoful... |
DB06448 | DB12001 | 171 | 564 | [
"DDInter1087",
"DDInter7"
] | Lonafarnib | Abemaciclib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
171,
25,
564
]
],
[
[
171,
63,
1051
],
[
1051,
24,
564
]
],
[
[
171,
24,
868
],
[
868,
24,
564
]
],
[
[
171,
64,
392
],
[
392,
2... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
"Am... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Vemura... |
DB00992 | DB01155 | 842 | 872 | [
"DDInter1182",
"DDInter813"
] | Methyl aminolevulinate (topical) | Gemifloxacin | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
842,
24,
872
]
],
[
[
842,
63,
739
],
[
739,
1,
872
]
],
[
[
842,
24,
956
],
[
956,
1,
872
]
],
[
[
842,
24,
945
],
[
945,
40,
... | [
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"L... | Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Methyl aminolevulinate may... |
DB00682 | DB00686 | 126 | 383 | [
"DDInter1951",
"DDInter1424"
] | Warfarin | Pentosan polysulfate | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Moderate | 1 | [
[
[
126,
24,
383
]
],
[
[
126,
24,
714
],
[
714,
63,
383
]
],
[
[
126,
64,
20
],
[
20,
24,
383
]
],
[
[
126,
25,
405
],
[
405,
63,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate
Warfarin may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may ... |
DB00099 | DB12674 | 440 | 975 | [
"DDInter735",
"DDInter1105"
] | Filgrastim | Lurbinectedin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
440,
24,
975
]
],
[
[
440,
24,
1488
],
[
1488,
24,
975
]
],
[
[
440,
63,
1560
],
[
1560,
24,
975
]
],
[
[
440,
24,
351
],
[
351,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and... |
DB00959 | DB11248 | 1,486 | 1,193 | [
"DDInter1191",
"DDInter1965"
] | Methylprednisolone | Zinc gluconate | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
1486,
23,
1193
]
],
[
[
1486,
24,
1531
],
[
1531,
23,
1193
]
],
[
[
1486,
40,
167
],
[
167,
23,
1193
]
],
[
[
1486,
24,
270
],
[
270,
... | [
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinum... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Methylprednisolone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a min... |
DB00446 | DB12825 | 597 | 1,375 | [
"DDInter351",
"DDInter1032"
] | Chloramphenicol | Lefamulin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
597,
24,
1375
]
],
[
[
597,
24,
112
],
[
112,
23,
1375
]
],
[
[
597,
24,
159
],
[
159,
63,
1375
]
],
[
[
597,
24,
1532
],
[
1532,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Larotrec... |
DB01190 | DB09065 | 568 | 760 | [
"DDInter398",
"DDInter424"
] | Clindamycin | Cobicistat | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
568,
24,
760
]
],
[
[
568,
63,
1438
],
[
1438,
24,
760
]
],
[
[
568,
24,
34
],
[
34,
24,
760
]
],
[
[
568,
24,
68
],
[
68,
63,
... | [
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fos... |
DB00401 | DB00501 | 84 | 752 | [
"DDInter1298",
"DDInter380"
] | Nisoldipine | Cimetidine | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
84,
24,
752
]
],
[
[
84,
6,
21998
],
[
21998,
45,
752
]
],
[
[
84,
21,
29134
],
[
29134,
60,
752
]
],
[
[
84,
25,
1166
],
[
1166,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Nisoldipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound... | Nisoldipine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cimetidine (Compound)
Nisoldipine (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Nisoldipine may lead to a major life threatening interaction when taken with Dolasetron ... |
DB01095 | DB09065 | 671 | 760 | [
"DDInter769",
"DDInter424"
] | Fluvastatin | Cobicistat | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
671,
24,
760
]
],
[
[
671,
24,
1374
],
[
1374,
23,
760
]
],
[
[
671,
63,
723
],
[
723,
24,
760
]
],
[
[
671,
24,
868
],
[
868,
2... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[... | Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Apre... |
DB00641 | DB00745 | 467 | 307 | [
"DDInter1675",
"DDInter1236"
] | Simvastatin | Modafinil | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Moderate | 1 | [
[
[
467,
24,
307
]
],
[
[
467,
63,
1236
],
[
1236,
40,
307
]
],
[
[
467,
24,
1335
],
[
1335,
40,
307
]
],
[
[
467,
6,
10215
],
[
10215,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
],
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Modafinil (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Modafinil... |
DB00981 | DB01193 | 1,528 | 819 | [
"DDInter1462",
"DDInter12"
] | Physostigmine | Acebutolol | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
1528,
24,
819
]
],
[
[
1528,
63,
887
],
[
887,
1,
819
]
],
[
[
1528,
21,
28653
],
[
28653,
60,
819
]
],
[
[
1528,
24,
1276
],
[
1276,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Physostigmine (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Acebutolol (Compound)
Physostigmine may cause a moderate int... |
DB01276 | DB09389 | 123 | 517 | [
"DDInter706",
"DDInter1315"
] | Exenatide | Norgestrel | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
123,
24,
517
]
],
[
[
123,
24,
1254
],
[
1254,
24,
517
]
],
[
[
123,
63,
629
],
[
629,
24,
517
]
],
[
[
123,
24,
1296
],
[
1296,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus... |
DB00376 | DB00747 | 1,105 | 1,442 | [
"DDInter1870",
"DDInter1647"
] | Trihexyphenidyl | Scopolamine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1105,
24,
1442
]
],
[
[
1105,
24,
19
],
[
19,
24,
1442
]
],
[
[
1105,
63,
1089
],
[
1089,
24,
1442
]
],
[
[
1105,
6,
7420
],
[
7420,
... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Ipratrop... |
DB00719 | DB00771 | 1,219 | 262 | [
"DDInter149",
"DDInter397"
] | Azatadine | Clidinium | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
1219,
24,
262
]
],
[
[
1219,
24,
1511
],
[
1511,
63,
262
]
],
[
[
1219,
63,
19
],
[
19,
24,
262
]
],
[
[
1219,
74,
1408
],
[
1408,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscy... |
DB00370 | DB08881 | 1,251 | 868 | [
"DDInter1230",
"DDInter1925"
] | Mirtazapine | Vemurafenib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1251,
25,
868
]
],
[
[
1251,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1251,
7,
5727
],
[
5727,
46,
868
]
],
[
[
1251,
21,
29015
],
[
29015,... | [
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemu... | Mirtazapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Mirtazapine (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Vemurafenib (Compound)
Mirtazapine (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Vemurafenib (Compou... |
DB01235 | DB01611 | 1,191 | 1,487 | [
"DDInter1054",
"DDInter893"
] | Levodopa | Hydroxychloroquine | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
1191,
24,
1487
]
],
[
[
1191,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1191,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
1191,
63,
168
],
[
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Levodopa",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Levodopa (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Levodopa (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib ... |
DB01229 | DB06636 | 973 | 1,623 | [
"DDInter1377",
"DDInter980"
] | Paclitaxel | Isavuconazonium | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
973,
24,
1623
]
],
[
[
973,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
973,
24,
309
],
[
309,
24,
1623
]
],
[
[
973,
24,
1593
],
[
1593,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixab... |
DB00208 | DB08816 | 1,018 | 578 | [
"DDInter1804",
"DDInter1802"
] | Ticlopidine | Ticagrelor | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1018,
24,
578
]
],
[
[
1018,
6,
17955
],
[
17955,
45,
578
]
],
[
[
1018,
54,
19166
],
[
19166,
15,
578
]
],
[
[
1018,
21,
28762
],
[
2... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"P2RY12"
],
[
"P2RY12",
"{u} (Gene) is bound by {v} (Compound)... | Ticlopidine (Compound) binds P2RY12 (Gene) and P2RY12 (Gene) is bound by Ticagrelor (Compound)
Ticlopidine (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class) and Decreased Platelet Aggregation (Pharmacologic Class) includes Ticagrelor (Compound)
Ticlopidine (Compound) causes Headache (Side E... |
DB00434 | DB01105 | 13 | 222 | [
"DDInter459",
"DDInter1665"
] | Cyproheptadine | Sibutramine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
13,
24,
222
]
],
[
[
13,
6,
7390
],
[
7390,
45,
222
]
],
[
[
13,
21,
28852
],
[
28852,
60,
222
]
],
[
[
13,
24,
1563
],
[
1563,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
],
[
"SLC6A2",
"{u} (Gene) is bound by {v} (Co... | Cyproheptadine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Sibutramine (Compound)
Cyproheptadine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Hal... |
DB06663 | DB15873 | 1,154 | 1,571 | [
"DDInter1398",
"DDInter443"
] | Pasireotide | Copper oxodotreotide Cu-64 | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over <sup>68</sup>Ga-labeled somatostatin analogs for positron emission tomography (PET). Copper Cu 64 dotatate has a longer half-life and can be produced once a day as opposed to several times a day, and lower positron ... | Major | 2 | [
[
[
1154,
25,
1571
]
],
[
[
1154,
1,
966
],
[
966,
25,
1571
]
],
[
[
1154,
23,
466
],
[
466,
62,
1446
],
[
1446,
25,
1571
]
],
[
[
1154,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Copper oxodotreotide Cu-64"
]
],
[
[
"Pasireotide",
"{u} (Compound) resembles {v} (Compound)",
"Octreotide"
],
[
"Octreotide",
"{u} may lead to a ma... | Pasireotide (Compound) resembles Octreotide (Compound) and Octreotide may lead to a major life threatening interaction when taken with Copper oxodotreotide Cu-64
Pasireotide may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can... |
DB00649 | DB06772 | 231 | 310 | [
"DDInter1710",
"DDInter259"
] | Stavudine | Cabazitaxel | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
231,
24,
310
]
],
[
[
231,
24,
973
],
[
973,
24,
310
]
],
[
[
231,
21,
28692
],
[
28692,
60,
310
]
],
[
[
231,
40,
139
],
[
139,
... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Stavudine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Cabazit... |
DB00312 | DB00501 | 1,023 | 752 | [
"DDInter1423",
"DDInter380"
] | Pentobarbital | Cimetidine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
1023,
23,
752
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
752
]
],
[
[
1023,
21,
28893
],
[
28893,
60,
752
]
],
[
[
1023,
24,
112
],
[
112,
... | [
[
[
"Pentobarbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Pentobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cimetidine (Compound)
Pentobarbital (Compound) causes Hallucination (Side Effect) and Hallucination (Side Effect) is caused by Cimetidine (Compound)
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB00397 | DB00912 | 1,466 | 473 | [
"DDInter1458",
"DDInter1581"
] | Phenylpropanolamine | Repaglinide | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1466,
24,
473
]
],
[
[
1466,
21,
29282
],
[
29282,
60,
473
]
],
[
[
1466,
36,
551
],
[
551,
24,
473
]
],
[
[
1466,
64,
73
],
[
73,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Arrhythmia"
],
[
"Arrhythmia",
"{u} ... | Phenylpropanolamine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Repaglinide (Compound)
Phenylpropanolamine (Compound) resembles Phenelzine (Compound) and Phenylpropanolamine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine may cause a mo... |
DB01197 | DB09481 | 1,603 | 460 | [
"DDInter292",
"DDInter1113"
] | Captopril | Magnesium carbonate | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1603,
23,
460
]
],
[
[
1603,
63,
401
],
[
401,
23,
460
]
],
[
[
1603,
40,
610
],
[
610,
23,
460
]
],
[
[
1603,
24,
820
],
[
820,
... | [
[
[
"Captopril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Captopril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that c... |
DB06616 | DB10276 | 594 | 1,624 | [
"DDInter224",
"DDInter1623"
] | Bosutinib | Rotavirus vaccine | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
594,
25,
1624
]
],
[
[
594,
25,
375
],
[
375,
25,
1624
]
],
[
[
594,
63,
58
],
[
58,
25,
1624
]
],
[
[
594,
64,
1220
],
[
1220,
... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
],
[
"Certolizumab... | Bosutinib may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may lead to a major life threatening interaction when taken with Rotavirus vaccine
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may le... |
DB00569 | DB00814 | 553 | 1,171 | [
"DDInter775",
"DDInter1143"
] | Fondaparinux | Meloxicam | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Major | 2 | [
[
[
553,
25,
1171
]
],
[
[
553,
64,
1027
],
[
1027,
40,
1171
]
],
[
[
553,
21,
28841
],
[
28841,
60,
1171
]
],
[
[
553,
63,
1560
],
[
1560... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meloxicam"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Piroxicam"
],
[
"Piroxicam",
"{u} ... | Fondaparinux may lead to a major life threatening interaction when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Fondaparinux (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Meloxicam (Compound)
Fondaparinux may cause a moderate interaction that co... |
DB06822 | DB11166 | 802 | 18 | [
"DDInter1812",
"DDInter104"
] | Tinzaparin | Antithrombin Alfa | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Major | 2 | [
[
[
802,
25,
18
]
],
[
[
802,
63,
1595
],
[
1595,
24,
18
]
],
[
[
802,
24,
116
],
[
116,
24,
18
]
],
[
[
802,
64,
714
],
[
714,
24,
... | [
[
[
"Tinzaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Collagenase clostridium histolyticu... | Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum and Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Antithrombin Alfa
Tinzaparin may cause a moderate interaction that coul... |
DB00060 | DB01263 | 912 | 859 | [
"DDInter947",
"DDInter1494"
] | Interferon beta-1a | Posaconazole | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
912,
24,
859
]
],
[
[
912,
24,
1101
],
[
1101,
23,
859
]
],
[
[
912,
24,
482
],
[
482,
24,
859
]
],
[
[
912,
24,
850
],
[
850,
6... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexaroten... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Posaconazole
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Tiogu... |
DB00889 | DB00978 | 1,133 | 739 | [
"DDInter840",
"DDInter1084"
] | Granisetron | Lomefloxacin | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
1133,
24,
739
]
],
[
[
1133,
25,
945
],
[
945,
40,
739
]
],
[
[
1133,
24,
872
],
[
872,
40,
739
]
],
[
[
1133,
64,
1176
],
[
1176,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Spar... | Granisetron may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Lomefloxacin (Compound)
G... |
DB04861 | DB09132 | 1,592 | 492 | [
"DDInter1271",
"DDInter797"
] | Nebivolol | Gadoteric acid | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Gadoteric acid, commonly used in the salt form gadoterate meglumine, is a macrocyclic, ionic gadolinium-based contrast agent (GBCA). It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). Gadoterate meglumine has one o... | Moderate | 1 | [
[
[
1592,
24,
492
]
],
[
[
1592,
5,
11590
],
[
11590,
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[
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]
],
[
[
1592,
6,
12523
],
[
12523,
45,
1081
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[
1081,
... | [
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoteric acid"
]
],
[
[
"Nebivolol",
"{u} (Compound) treats {v} (Disease)",
"hypertension"
],
[
"hypertension",
"{u} (Disease) is trea... | Nebivolol (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Gadoteric acid
Nebivolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nicardipine (Compound) ... |
DB08899 | DB09101 | 129 | 70 | [
"DDInter649",
"DDInter633"
] | Enzalutamide | Elvitegravir | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome ... | Major | 2 | [
[
[
129,
25,
70
]
],
[
[
129,
25,
1017
],
[
1017,
63,
70
]
],
[
[
129,
64,
868
],
[
868,
24,
70
]
],
[
[
129,
24,
286
],
[
286,
63,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Elvitegravir"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
],
[
"Lorlatinib",
... | Enzalutamide may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Elvitegravir
Enzalutamide may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moder... |
DB01115 | DB01168 | 336 | 1,053 | [
"DDInter1291",
"DDInter1526"
] | Nifedipine | Procarbazine | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
336,
24,
1053
]
],
[
[
336,
63,
848
],
[
848,
40,
1053
]
],
[
[
336,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
336,
63,
104
],
[
104,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Nifedipine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Nifedipine may cause a moderate interaction ... |
DB00501 | DB00543 | 752 | 87 | [
"DDInter380",
"DDInter82"
] | Cimetidine | Amoxapine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Moderate | 1 | [
[
[
752,
24,
87
]
],
[
[
752,
63,
1119
],
[
1119,
1,
87
]
],
[
[
752,
24,
1418
],
[
1418,
1,
87
]
],
[
[
752,
23,
623
],
[
623,
40,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlordiazepoxide"
],
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Amoxapine (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Amoxapine (Co... |
DB01095 | DB08865 | 671 | 1,593 | [
"DDInter769",
"DDInter448"
] | Fluvastatin | Crizotinib | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
671,
24,
1593
]
],
[
[
671,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
671,
18,
2900
],
[
2900,
46,
1593
]
],
[
[
671,
7,
18134
],
[
18134,
... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Fluvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Fluvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Fluvastatin (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Crizotinib (Compound)
Fluvastatin (Compound) upregulates POLD4 (Gene) and POLD4 (Gene) is upregulated by Crizotinib (Compound)
Fluvastatin... |
DB00075 | DB08908 | 541 | 713 | [
"DDInter1250",
"DDInter564"
] | Muromonab | Dimethyl fumarate | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
541,
24,
713
]
],
[
[
541,
24,
4
],
[
4,
24,
713
]
],
[
[
541,
24,
270
],
[
270,
63,
713
]
],
[
[
541,
63,
1184
],
[
1184,
24,
... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccin... | Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Muromonab may cause a moderate interaction that could exacerbate diseases wh... |
DB01394 | DB09498 | 1,554 | 810 | [
"DDInter431",
"DDInter1715"
] | Colchicine | Strontium chloride Sr-89 | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1554,
24,
810
]
],
[
[
1554,
63,
1555
],
[
1555,
24,
810
]
],
[
[
1554,
24,
310
],
[
310,
24,
810
]
],
[
[
1554,
24,
1480
],
[
1480,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Cabaz... |
DB00316 | DB00704 | 474 | 267 | [
"DDInter14",
"DDInter1263"
] | Acetaminophen | Naltrexone | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
474,
24,
267
]
],
[
[
474,
6,
4973
],
[
4973,
45,
267
]
],
[
[
474,
21,
28695
],
[
28695,
60,
267
]
],
[
[
474,
24,
850
],
[
850,
... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Acetaminophen",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Acetaminophen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Naltrexone (Compound)
Acetaminophen (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Naltrexone (Compound)
Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ve... |
DB06636 | DB09330 | 1,623 | 985 | [
"DDInter980",
"DDInter1352"
] | Isavuconazonium | Osimertinib | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1623,
24,
985
]
],
[
[
1623,
25,
1478
],
[
1478,
24,
985
]
],
[
[
1623,
63,
134
],
[
134,
24,
985
]
],
[
[
1623,
24,
119
],
[
119,
... | [
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"... | Isavuconazonium may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine... |
DB00562 | DB09156 | 1,014 | 777 | [
"DDInter188",
"DDInter964"
] | Benzthiazide | Iopromide | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
1014,
24,
777
]
],
[
[
1014,
63,
1648
],
[
1648,
24,
777
]
],
[
[
1014,
40,
674
],
[
674,
24,
777
]
],
[
[
1014,
1,
323
],
[
323,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Benzthiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate i... |
DB00196 | DB00425 | 600 | 558 | [
"DDInter743",
"DDInter1970"
] | Fluconazole | Zolpidem | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Moderate | 1 | [
[
[
600,
24,
558
]
],
[
[
600,
6,
8374
],
[
8374,
45,
558
]
],
[
[
600,
21,
29442
],
[
29442,
60,
558
]
],
[
[
600,
25,
868
],
[
868,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zolpidem (Compound)
Fluconazole (Compound) causes Abnormal vision (Side Effect) and Abnormal vision (Side Effect) is caused by Zolpidem (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Vemurafenib and Vemuraf... |
DB00348 | DB01261 | 254 | 170 | [
"DDInter1300",
"DDInter1679"
] | Nitisinone | Sitagliptin | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
254,
24,
170
]
],
[
[
254,
21,
29350
],
[
29350,
60,
170
]
],
[
[
254,
24,
129
],
[
129,
63,
170
]
],
[
[
254,
24,
1072
],
[
1072,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Bronchitis"
],
[
"Bronchitis",
"{u} (Side Effect) is c... | Nitisinone (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Sitagliptin (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00912 | DB01072 | 473 | 915 | [
"DDInter1581",
"DDInter129"
] | Repaglinide | Atazanavir | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
473,
24,
915
]
],
[
[
473,
24,
1327
],
[
1327,
1,
915
]
],
[
[
473,
6,
8374
],
[
8374,
45,
915
]
],
[
[
473,
21,
28810
],
[
28810,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Atazanavir (Compound)
Repaglinide (Compound) causes Gastrointestinal pain (Side Effect... |
DB00421 | DB01234 | 443 | 1,220 | [
"DDInter1707",
"DDInter513"
] | Spironolactone | Dexamethasone | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
443,
24,
1220
]
],
[
[
443,
24,
870
],
[
870,
1,
1220
]
],
[
[
443,
24,
175
],
[
175,
40,
1220
]
],
[
[
443,
1,
1581
],
[
1581,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resem... |
DB12010 | DB13179 | 214 | 68 | [
"DDInter785",
"DDInter1882"
] | Fostamatinib | Troleandomycin | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA. Recently, fosta... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
214,
25,
68
]
],
[
[
214,
63,
1601
],
[
1601,
23,
68
]
],
[
[
214,
63,
309
],
[
309,
24,
68
]
],
[
[
214,
64,
760
],
[
760,
24,
... | [
[
[
"Fostamatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Fostamatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
],
[
"Lo... | Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and... |
DB00046 | DB00685 | 1,179 | 1,299 | [
"DDInter940",
"DDInter1887"
] | Insulin lispro | Trovafloxacin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Major | 2 | [
[
[
1179,
25,
1299
]
],
[
[
1179,
25,
872
],
[
872,
40,
1299
]
],
[
[
1179,
24,
1479
],
[
1479,
63,
1299
]
],
[
[
1179,
24,
1560
],
[
1560... | [
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin... | Insulin lispro may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate in... |
DB04835 | DB04868 | 1,655 | 478 | [
"DDInter1125",
"DDInter1293"
] | Maraviroc | Nilotinib | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1655,
24,
478
]
],
[
[
1655,
24,
1468
],
[
1468,
63,
478
]
],
[
[
1655,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1655,
18,
7247
],
[
7247,
... | [
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Maraviroc (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Maraviroc (Compound) dow... |
DB00584 | DB00860 | 610 | 891 | [
"DDInter638",
"DDInter1513"
] | Enalapril | Prednisolone | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
610,
24,
891
]
],
[
[
610,
24,
175
],
[
175,
40,
891
]
],
[
[
610,
24,
167
],
[
167,
1,
891
]
],
[
[
610,
63,
251
],
[
251,
1,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Predniso... |
DB01129 | DB08901 | 379 | 1,468 | [
"DDInter1559",
"DDInter1492"
] | Rabeprazole | Ponatinib | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Minor | 0 | [
[
[
379,
23,
1468
]
],
[
[
379,
24,
478
],
[
478,
24,
1468
]
],
[
[
379,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
379,
21,
29271
],
[
29271,... | [
[
[
"Rabeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
]
],
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Rabeprazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Rabeprazole (Compoun... |
DB00694 | DB08880 | 51 | 1,510 | [
"DDInter485",
"DDInter1771"
] | Daunorubicin | Teriflunomide | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
51,
25,
1510
]
],
[
[
51,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
51,
24,
129
],
[
129,
63,
1510
]
],
[
[
51,
24,
1136
],
[
1136,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vita... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and E... |
DB06688 | DB11952 | 1,430 | 800 | [
"DDInter1677",
"DDInter612"
] | Sipuleucel-T | Duvelisib | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1430,
24,
800
]
],
[
[
1430,
24,
310
],
[
310,
24,
800
]
],
[
[
1430,
24,
1476
],
[
1476,
63,
800
]
],
[
[
1430,
63,
663
],
[
663,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and B... |
DB00358 | DB01169 | 1,010 | 57 | [
"DDInter1140",
"DDInter120"
] | Mefloquine | Arsenic trioxide | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1010,
25,
57
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1010,
23,
1247
],
[
1247,
23,
57
]
],
[
[
1010,
24,
603
],
[
603,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"A... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxid... |
DB00188 | DB09038 | 168 | 1,450 | [
"DDInter222",
"DDInter636"
] | Bortezomib | Empagliflozin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
168,
24,
1450
]
],
[
[
168,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
168,
24,
245
],
[
245,
24,
1450
]
],
[
[
168,
24,
1017
],
[
1017,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin lispro"
],
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Glimepirid... |
DB00014 | DB01403 | 521 | 9 | [
"DDInter839",
"DDInter1175"
] | Goserelin | Methotrimeprazine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
521,
24,
9
]
],
[
[
521,
24,
1178
],
[
1178,
40,
9
]
],
[
[
521,
24,
1164
],
[
1164,
1,
9
]
],
[
[
521,
25,
684
],
[
684,
40,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Met... |
DB00365 | DB09080 | 839 | 144 | [
"DDInter842",
"DDInter1331"
] | Grepafloxacin | Olodaterol | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
839,
24,
144
]
],
[
[
839,
25,
1011
],
[
1011,
24,
144
]
],
[
[
839,
24,
543
],
[
543,
24,
144
]
],
[
[
839,
64,
600
],
[
600,
2... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fing... | Grepafloxacin may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may ... |
DB00086 | DB00991 | 1,167 | 97 | [
"DDInter1712",
"DDInter1358"
] | Streptokinase | Oxaprozin | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
1167,
24,
97
]
],
[
[
1167,
24,
1274
],
[
1274,
24,
97
]
],
[
[
1167,
25,
936
],
[
936,
63,
97
]
],
[
[
1167,
64,
1578
],
[
1578,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Streptokinase may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may... |
DB01124 | DB01261 | 1,411 | 170 | [
"DDInter1828",
"DDInter1679"
] | Tolbutamide | Sitagliptin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1411,
24,
170
]
],
[
[
1411,
5,
11640
],
[
11640,
44,
170
]
],
[
[
1411,
6,
3486
],
[
3486,
45,
170
]
],
[
[
1411,
21,
28792
],
[
2879... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Tolbutamide",
"{u} (Compound) treats {v} (Disease)",
"type 2 diabetes mellitus"
],
[
"type 2 diabetes mellitus",
... | Tolbutamide (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Sitagliptin (Compound)
Tolbutamide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Tolbutamide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastroint... |
DB00047 | DB01072 | 176 | 915 | [
"DDInter932",
"DDInter129"
] | Insulin glargine | Atazanavir | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
176,
24,
915
]
],
[
[
176,
24,
1327
],
[
1327,
1,
915
]
],
[
[
176,
24,
5
],
[
5,
63,
915
]
],
[
[
176,
24,
1101
],
[
1101,
24,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interact... |
DB00968 | DB01234 | 1,551 | 1,220 | [
"DDInter1185",
"DDInter513"
] | Methyldopa | Dexamethasone | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1551,
24,
1220
]
],
[
[
1551,
63,
870
],
[
870,
1,
1220
]
],
[
[
1551,
63,
175
],
[
175,
40,
1220
]
],
[
[
1551,
24,
617
],
[
617,
... | [
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Methyldopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00041 | DB00189 | 1,648 | 459 | [
"DDInter38",
"DDInter691"
] | Aldesleukin | Ethchlorvynol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | Moderate | 1 | [
[
[
1648,
24,
459
]
],
[
[
1648,
24,
1264
],
[
1264,
63,
459
]
],
[
[
1648,
25,
593
],
[
593,
63,
459
]
],
[
[
1648,
24,
475
],
[
475,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethchlorvynol"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Ethchlorvynol
Aldesleukin may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a m... |
DB00014 | DB14509 | 521 | 1,399 | [
"DDInter839",
"DDInter1081"
] | Goserelin | Lithium carbonate | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
521,
24,
1399
]
],
[
[
521,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
521,
1,
774
],
[
774,
24,
1399
]
],
[
[
521,
23,
112
],
[
112,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
],
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide and Semaglutide may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Goserelin (Compound) resembles Degarelix (Compound) and Degarelix may cause a moderate interaction that ... |
DB00682 | DB08875 | 126 | 1,618 | [
"DDInter1951",
"DDInter262"
] | Warfarin | Cabozantinib | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
126,
25,
1618
]
],
[
[
126,
25,
112
],
[
112,
23,
1618
]
],
[
[
126,
63,
723
],
[
723,
24,
1618
]
],
[
[
126,
24,
384
],
[
384,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metronidazole"
],
[
"Metronidazole",
"{... | Warfarin may lead to a major life threatening interaction when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may caus... |
DB00060 | DB01206 | 912 | 37 | [
"DDInter947",
"DDInter1086"
] | Interferon beta-1a | Lomustine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
912,
24,
37
]
],
[
[
912,
24,
1176
],
[
1176,
23,
37
]
],
[
[
912,
24,
637
],
[
637,
63,
37
]
],
[
[
912,
24,
328
],
[
328,
24,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moxifloxacin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Lomustine
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Aspa... |
DB00500 | DB06779 | 24 | 365 | [
"DDInter1831",
"DDInter470"
] | Tolmetin | Dalteparin | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
24,
25,
365
]
],
[
[
24,
63,
305
],
[
305,
24,
365
]
],
[
[
24,
24,
1039
],
[
1039,
24,
365
]
],
[
[
24,
24,
738
],
[
738,
63,
... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
],
[
... | Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Tolmetin may cause a moderate interaction that could exacerbate diseases whe... |
DB05316 | DB11110 | 749 | 603 | [
"DDInter1467",
"DDInter1115"
] | Pimavanserin | Magnesium citrate | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
749,
24,
603
]
],
[
[
749,
64,
57
],
[
57,
24,
603
]
],
[
[
749,
24,
1616
],
[
1616,
24,
603
]
],
[
[
749,
63,
1151
],
[
1151,
2... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Pimavanserin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Pimavanserin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and... |
DB00361 | DB09115 | 134 | 505 | [
"DDInter1939",
"DDInter559"
] | Vinorelbine | Diiodohydroxyquinoline | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
134,
24,
505
]
],
[
[
134,
24,
1593
],
[
1593,
24,
505
]
],
[
[
134,
25,
908
],
[
908,
24,
505
]
],
[
[
134,
63,
168
],
[
168,
2... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Vinorelbine may lead to a major life threatening interaction when taken with Golimumab and Golimuma... |
DB00619 | DB01320 | 1,419 | 651 | [
"DDInter909",
"DDInter783"
] | Imatinib | Fosphenytoin | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Major | 2 | [
[
[
1419,
25,
651
]
],
[
[
1419,
23,
307
],
[
307,
1,
651
]
],
[
[
1419,
64,
362
],
[
362,
1,
651
]
],
[
[
1419,
24,
998
],
[
998,
1... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Imatinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Imatinib may cause a ... |
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