drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00370 | DB00514 | 1,251 | 506 | [
"DDInter1230",
"DDInter527"
] | Mirtazapine | Dextromethorphan | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Major | 2 | [
[
[
1251,
25,
506
]
],
[
[
1251,
6,
8374
],
[
8374,
45,
506
]
],
[
[
1251,
7,
5727
],
[
5727,
46,
506
]
],
[
[
1251,
21,
28810
],
[
28810,... | [
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Mirtazapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Mirtazapine (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Dextromethorphan (Compound)
Mirtazapine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is c... |
DB00651 | DB00983 | 746 | 480 | [
"DDInter613",
"DDInter776"
] | Dyphylline | Formoterol | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
746,
24,
480
]
],
[
[
746,
24,
1148
],
[
1148,
63,
480
]
],
[
[
746,
64,
1523
],
[
1523,
25,
480
]
],
[
[
746,
5,
11649
],
[
11649,
... | [
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Dyphylline may lead to a major life threatening interaction when taken with Labetalol and Labetalol may lead... |
DB00341 | DB14740 | 1,242 | 771 | [
"DDInter343",
"DDInter881"
] | Cetirizine | Hyaluronidase | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1242,
23,
771
]
],
[
[
1242,
24,
849
],
[
849,
23,
771
]
],
[
[
1242,
40,
1413
],
[
1413,
23,
771
]
],
[
[
1242,
74,
701
],
[
701,
... | [
[
[
"Cetirizine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Cetirizine (Compound) resembles Fexofenadine (Compound) and Fexofenadine may cause a minor interaction that can... |
DB11601 | DB11921 | 1,270 | 1,019 | [
"DDInter1889",
"DDInter492"
] | Tuberculin purified protein derivative | Deflazacort | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1270,
24,
1019
]
],
[
[
1270,
24,
270
],
[
270,
63,
1019
]
],
[
[
1270,
63,
629
],
[
629,
24,
1019
]
],
[
[
1270,
24,
1316
],
[
1316,
... | [
[
[
"Tuberculin purified protein derivative",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Tuberculin purified protein derivative",
"{u} may cause a moderate interaction that could exacerbate diseases... | Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Tuberculin purified protein derivative may cause a moderate interaction that coul... |
DB00363 | DB01124 | 695 | 1,411 | [
"DDInter419",
"DDInter1828"
] | Clozapine | Tolbutamide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
695,
24,
1411
]
],
[
[
695,
24,
959
],
[
959,
40,
1411
]
],
[
[
695,
63,
245
],
[
245,
40,
1411
]
],
[
[
695,
6,
10215
],
[
10215,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB00635 | DB08880 | 1,573 | 1,510 | [
"DDInter1515",
"DDInter1771"
] | Prednisone | Teriflunomide | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1573,
25,
1510
]
],
[
[
1573,
62,
1461
],
[
1461,
23,
1510
]
],
[
[
1573,
23,
1193
],
[
1193,
62,
1510
]
],
[
[
1573,
24,
221
],
[
221... | [
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Prednisone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gl... |
DB01233 | DB09112 | 1,311 | 1,455 | [
"DDInter1197",
"DDInter1306"
] | Metoclopramide | Nitrous acid | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
1311,
25,
1455
]
],
[
[
1311,
63,
1020
],
[
1020,
24,
1455
]
],
[
[
1311,
24,
1084
],
[
1084,
24,
1455
]
],
[
[
1311,
64,
490
],
[
490... | [
[
[
"Metoclopramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
"C... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine an... |
DB00835 | DB00985 | 100 | 1,443 | [
"DDInter245",
"DDInter562"
] | Brompheniramine | Dimenhydrinate | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Moderate | 1 | [
[
[
100,
24,
1443
]
],
[
[
100,
1,
11296
],
[
11296,
1,
1443
]
],
[
[
100,
35,
1376
],
[
1376,
63,
1443
]
],
[
[
100,
24,
537
],
[
537,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimenhydrinate"
]
],
[
[
"Brompheniramine",
"{u} (Compound) resembles {v} (Compound)",
"Bromodiphenhydramine"
],
[
"Bromodiphenhydramin... | Brompheniramine (Compound) resembles Bromodiphenhydramine (Compound) and Bromodiphenhydramine (Compound) resembles Dimenhydrinate (Compound)
Brompheniramine (Compound) resembles Diphenhydramine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine... |
DB00241 | DB00254 | 288 | 964 | [
"DDInter257",
"DDInter598"
] | Butalbital | Doxycycline | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Moderate | 1 | [
[
[
288,
24,
964
]
],
[
[
288,
24,
1424
],
[
1424,
62,
964
]
],
[
[
288,
40,
1023
],
[
1023,
63,
964
]
],
[
[
288,
24,
384
],
[
384,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Butalbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital may cause a moderate interaction that could ... |
DB01097 | DB01229 | 1,377 | 973 | [
"DDInter1033",
"DDInter1377"
] | Leflunomide | Paclitaxel | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Major | 2 | [
[
[
1377,
25,
973
]
],
[
[
1377,
25,
310
],
[
310,
63,
973
]
],
[
[
1377,
6,
6017
],
[
6017,
45,
973
]
],
[
[
1377,
7,
9489
],
[
9489,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel",
"{... | Leflunomide may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Leflunomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paclitaxel (Compound)
Leflunomide (Compound) upregu... |
DB01105 | DB14723 | 222 | 159 | [
"DDInter1665",
"DDInter1026"
] | Sibutramine | Larotrectinib | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Minor | 0 | [
[
[
222,
23,
159
]
],
[
[
222,
25,
318
],
[
318,
23,
159
]
],
[
[
222,
64,
1230
],
[
1230,
23,
159
]
],
[
[
222,
24,
1375
],
[
1375,
... | [
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Larotrectinib"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escit... | Sibutramine may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Sibutramine may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause a minor ... |
DB01240 | DB06754 | 885 | 707 | [
"DDInter657",
"DDInter471"
] | Epoprostenol | Danaparoid | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
885,
25,
707
]
],
[
[
885,
23,
944
],
[
944,
62,
707
]
],
[
[
885,
63,
863
],
[
863,
24,
707
]
],
[
[
885,
24,
1004
],
[
1004,
6... | [
[
[
"Epoprostenol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Epoprostenol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile... | Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Danaparoid
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Amiloride and Amiloride... |
DB00867 | DB00938 | 1,052 | 455 | [
"DDInter1606",
"DDInter1635"
] | Ritodrine | Salmeterol | Adrenergic beta-agonist used to control premature labor. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1052,
24,
455
]
],
[
[
1052,
1,
1523
],
[
1523,
25,
455
]
],
[
[
1052,
24,
688
],
[
688,
63,
455
]
],
[
[
1052,
40,
1188
],
[
1188,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Ritodrine",
"{u} (Compound) resembles {v} (Compound)",
"Labetalol"
],
[
"Labetalol",
"{u} may lead to a major lif... | Ritodrine (Compound) resembles Labetalol (Compound) and Labetalol may lead to a major life threatening interaction when taken with Salmeterol
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate disease... |
DB01577 | DB09080 | 1,529 | 144 | [
"DDInter1161",
"DDInter1331"
] | Metamfetamine | Olodaterol | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1529,
24,
144
]
],
[
[
1529,
74,
1445
],
[
1445,
24,
144
]
],
[
[
1529,
63,
1324
],
[
1324,
24,
144
]
],
[
[
1529,
1,
80
],
[
80,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Metamfetamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when t... | Metamfetamine (Compound) resembles Pseudoephedrine (Compound) and Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Metamfetamine may cause a moderat... |
DB00497 | DB11130 | 828 | 407 | [
"DDInter1366",
"DDInter1344"
] | Oxycodone | Opium | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
828,
24,
407
]
],
[
[
828,
24,
662
],
[
662,
24,
407
]
],
[
[
828,
63,
1233
],
[
1233,
24,
407
]
],
[
[
828,
64,
475
],
[
475,
2... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine and Tripr... |
DB00741 | DB14740 | 167 | 771 | [
"DDInter885",
"DDInter881"
] | Hydrocortisone | Hyaluronidase | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
167,
23,
771
]
],
[
[
167,
24,
1438
],
[
1438,
23,
771
]
],
[
[
167,
1,
617
],
[
617,
23,
771
]
],
[
[
167,
63,
380
],
[
380,
23... | [
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Hydrocortisone (Compound) resembles Budesonide (Compound) and Budesonide may cause a minor interaction that c... |
DB01172 | DB11071 | 416 | 1,004 | [
"DDInter1004",
"DDInter1449"
] | Kanamycin | Phenyl salicylate | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
416,
24,
1004
]
],
[
[
416,
63,
837
],
[
837,
23,
1004
]
],
[
[
416,
24,
101
],
[
101,
23,
1004
]
],
[
[
416,
74,
1132
],
[
1132,
... | [
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pantoprazole"
],
... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazol... |
DB00209 | DB00344 | 352 | 1,302 | [
"DDInter1886",
"DDInter1543"
] | Trospium | Protriptyline | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Moderate | 1 | [
[
[
352,
24,
1302
]
],
[
[
352,
24,
413
],
[
413,
1,
1302
]
],
[
[
352,
24,
1405
],
[
1405,
40,
1302
]
],
[
[
352,
24,
13
],
[
13,
6... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Protriptyline (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Protriptyli... |
DB01359 | DB06292 | 729 | 549 | [
"DDInter1417",
"DDInter474"
] | Penbutolol | Dapagliflozin | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
729,
24,
549
]
],
[
[
729,
24,
1344
],
[
1344,
40,
549
]
],
[
[
729,
21,
28882
],
[
28882,
60,
549
]
],
[
[
729,
63,
1636
],
[
1636,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Penbutolol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dapagliflozin (Compound... |
DB00703 | DB01105 | 997 | 222 | [
"DDInter1167",
"DDInter1665"
] | Methazolamide | Sibutramine | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
997,
24,
222
]
],
[
[
997,
6,
8374
],
[
8374,
45,
222
]
],
[
[
997,
21,
28852
],
[
28852,
60,
222
]
],
[
[
997,
24,
659
],
[
659,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Methazolamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Methazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Methazolamide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Vilant... |
DB00331 | DB00451 | 1,645 | 542 | [
"DDInter1164",
"DDInter1064"
] | Metformin | Levothyroxine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
1645,
24,
542
]
],
[
[
1645,
24,
624
],
[
624,
1,
542
]
],
[
[
1645,
63,
1152
],
[
1152,
1,
542
]
],
[
[
1645,
7,
7273
],
[
7273,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Levothyroxine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (Compound... |
DB00446 | DB06702 | 597 | 573 | [
"DDInter351",
"DDInter731"
] | Chloramphenicol | Fesoterodine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
597,
24,
573
]
],
[
[
597,
24,
211
],
[
211,
1,
573
]
],
[
[
597,
6,
8374
],
[
8374,
45,
573
]
],
[
[
597,
21,
28681
],
[
28681,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fesoterodine (Compound)
Chloramphenicol (Compound) causes Hypersensitivity... |
DB00489 | DB00668 | 17 | 874 | [
"DDInter1704",
"DDInter652"
] | Sotalol | Epinephrine | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Major | 2 | [
[
[
17,
25,
874
]
],
[
[
17,
63,
1636
],
[
1636,
1,
874
]
],
[
[
17,
25,
688
],
[
688,
63,
874
]
],
[
[
17,
36,
1674
],
[
1674,
63,
... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
]
],
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
"Phenylephrin... | Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Sotalol may lead to a major life threatening interaction when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate di... |
DB00420 | DB01362 | 508 | 497 | [
"DDInter1532",
"DDInter960"
] | Promazine | Iohexol | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
508,
25,
497
]
],
[
[
508,
18,
6929
],
[
6929,
57,
497
]
],
[
[
508,
24,
530
],
[
530,
25,
497
]
],
[
[
508,
1,
1237
],
[
1237,
... | [
[
[
"Promazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Promazine",
"{u} (Compound) downregulates {v} (Gene)",
"ITGAE"
],
[
"ITGAE",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Promazine (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Iohexol (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may lead to a major life threatening interaction when taken with Iohexol
Promazine (Compound) resemb... |
DB00792 | DB00981 | 832 | 1,528 | [
"DDInter1878",
"DDInter1462"
] | Tripelennamine | Physostigmine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
832,
24,
1528
]
],
[
[
832,
40,
508
],
[
508,
24,
1528
]
],
[
[
832,
63,
87
],
[
87,
24,
1528
]
],
[
[
832,
24,
1511
],
[
1511,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Tripelennamine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause ... | Tripelennamine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine may cause a moderate interaction tha... |
DB00434 | DB00719 | 13 | 1,219 | [
"DDInter459",
"DDInter149"
] | Cyproheptadine | Azatadine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
13,
24,
1219
]
],
[
[
13,
1,
11693
],
[
11693,
40,
1219
]
],
[
[
13,
40,
11416
],
[
11416,
1,
1219
]
],
[
[
13,
24,
830
],
[
830,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) resembles {v} (Compound)",
"Ketotifen"
],
[
"Ketotifen",
"{u} (Compound) res... | Cyproheptadine (Compound) resembles Ketotifen (Compound) and Ketotifen (Compound) resembles Azatadine (Compound)
Cyproheptadine (Compound) resembles Alcaftadine (Compound) and Alcaftadine (Compound) resembles Azatadine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01234 | DB11575 | 1,220 | 1,676 | [
"DDInter513",
"DDInter841"
] | Dexamethasone | Grazoprevir | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Major | 2 | [
[
[
1220,
25,
1676
]
],
[
[
1220,
63,
723
],
[
723,
24,
1676
]
],
[
[
1220,
24,
868
],
[
868,
24,
1676
]
],
[
[
1220,
24,
351
],
[
351,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Grazoprevir"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
"Apr... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib an... |
DB00047 | DB08815 | 176 | 154 | [
"DDInter932",
"DDInter1104"
] | Insulin glargine | Lurasidone | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
176,
24,
154
]
],
[
[
176,
24,
1033
],
[
1033,
63,
154
]
],
[
[
176,
24,
1446
],
[
1446,
24,
154
]
],
[
[
176,
23,
274
],
[
274,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide ... |
DB01612 | DB06292 | 1,637 | 549 | [
"DDInter92",
"DDInter474"
] | Amyl Nitrite | Dapagliflozin | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1637,
24,
549
]
],
[
[
1637,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1637,
63,
1630
],
[
1630,
24,
549
]
],
[
[
1637,
24,
1241
],
[
1241,... | [
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Amyl Nitrite",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]... | Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine may cause a moderate inter... |
DB00562 | DB01001 | 1,014 | 688 | [
"DDInter188",
"DDInter1632"
] | Benzthiazide | Salbutamol | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1014,
24,
688
]
],
[
[
1014,
24,
455
],
[
455,
24,
688
]
],
[
[
1014,
24,
1220
],
[
1220,
62,
688
]
],
[
[
1014,
24,
870
],
[
870,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and... |
DB00860 | DB14730 | 891 | 1,412 | [
"DDInter1513",
"DDInter264"
] | Prednisolone | Calaspargase pegol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
891,
24,
1412
]
],
[
[
891,
24,
1439
],
[
1439,
24,
1412
]
],
[
[
891,
63,
1144
],
[
1144,
24,
1412
]
],
[
[
891,
40,
251
],
[
251,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Nateglini... |
DB00242 | DB12267 | 1,064 | 1,476 | [
"DDInter392",
"DDInter233"
] | Cladribine | Brigatinib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
1064,
25,
1476
]
],
[
[
1064,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
1064,
64,
168
],
[
168,
23,
1476
]
],
[
[
1064,
25,
629
],
[
629,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
"Fostemsav... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Cladribine may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause ... |
DB00222 | DB00834 | 245 | 932 | [
"DDInter825",
"DDInter1215"
] | Glimepiride | Mifepristone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
245,
24,
932
]
],
[
[
245,
21,
28762
],
[
28762,
60,
932
]
],
[
[
245,
24,
1101
],
[
1101,
23,
932
]
],
[
[
245,
24,
480
],
[
480,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is ca... | Glimepiride (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Mifepri... |
DB00295 | DB11915 | 475 | 1,293 | [
"DDInter1244",
"DDInter1909"
] | Morphine | Valbenazine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
475,
24,
1293
]
],
[
[
475,
24,
516
],
[
516,
24,
1293
]
],
[
[
475,
63,
701
],
[
701,
24,
1293
]
],
[
[
475,
24,
124
],
[
124,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and C... |
DB01175 | DB11986 | 318 | 484 | [
"DDInter672",
"DDInter648"
] | Escitalopram | Entrectinib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
318,
25,
484
]
],
[
[
318,
62,
112
],
[
112,
23,
484
]
],
[
[
318,
64,
222
],
[
222,
23,
484
]
],
[
[
318,
25,
774
],
[
774,
24,... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Escitalopram may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine m... |
DB00635 | DB06636 | 1,573 | 1,623 | [
"DDInter1515",
"DDInter980"
] | Prednisone | Isavuconazonium | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1573,
24,
1623
]
],
[
[
1573,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
1573,
40,
167
],
[
167,
24,
1623
]
],
[
[
1573,
24,
1213
],
[
1213... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Prednisone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction t... |
DB00694 | DB14443 | 51 | 987 | [
"DDInter485",
"DDInter1931"
] | Daunorubicin | Vibrio cholerae CVD 103-HgR strain live antigen | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
51,
24,
987
]
],
[
[
51,
63,
141
],
[
141,
24,
987
]
],
[
[
51,
24,
1468
],
[
1468,
24,
987
]
],
[
[
51,
25,
351
],
[
351,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Daunorubicin may cause a moderate interaction that could exacerbate dis... |
DB00283 | DB00810 | 701 | 456 | [
"DDInter395",
"DDInter211"
] | Clemastine | Biperiden | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Moderate | 1 | [
[
[
701,
24,
456
]
],
[
[
701,
24,
1105
],
[
1105,
40,
456
]
],
[
[
701,
1,
11268
],
[
11268,
40,
456
]
],
[
[
701,
6,
12523
],
[
12523,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Clemastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Biperiden (Compound)
Clemastine (Compound) binds CYP2D6 (... |
DB00687 | DB04575 | 870 | 35 | [
"DDInter747",
"DDInter1555"
] | Fludrocortisone | Quinestrol | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
870,
24,
35
]
],
[
[
870,
24,
890
],
[
890,
1,
35
]
],
[
[
870,
63,
559
],
[
559,
1,
35
]
],
[
[
870,
24,
177
],
[
177,
40,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Estrone and Estrone (Compound) resembles Quinestrol (Compound... |
DB01377 | DB06817 | 1,283 | 809 | [
"DDInter1119",
"DDInter1563"
] | Magnesium oxide | Raltegravir | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. | Moderate | 1 | [
[
[
1283,
24,
809
]
],
[
[
1283,
24,
478
],
[
478,
23,
809
]
],
[
[
1283,
62,
1559
],
[
1559,
23,
809
]
],
[
[
1283,
24,
853
],
[
853,
... | [
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Raltegravir"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a minor interaction that can limit clinical effects when taken with Raltegravir
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Famotidine and F... |
DB00333 | DB01069 | 576 | 401 | [
"DDInter1166",
"DDInter1533"
] | Methadone | Promethazine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Major | 2 | [
[
[
576,
36,
401
]
],
[
[
576,
40,
11245
],
[
11245,
1,
401
]
],
[
[
576,
1,
146
],
[
146,
24,
401
]
],
[
[
576,
25,
1264
],
[
1264,
... | [
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
]
],
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound)",
"Ethopropazine"
],
[
"Ethopropazi... | Methadone (Compound) resembles Promethazine (Compound) and
Methadone (Compound) resembles Ethopropazine (Compound) and Ethopropazine (Compound) resembles Promethazine (Compound)
Methadone (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerbate diseases when t... |
DB00436 | DB13928 | 323 | 1,385 | [
"DDInter179",
"DDInter1660"
] | Bendroflumethiazide | Semaglutide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
323,
24,
1385
]
],
[
[
323,
24,
891
],
[
891,
24,
1385
]
],
[
[
323,
63,
1179
],
[
1179,
24,
1385
]
],
[
[
323,
40,
178
],
[
178,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Predniso... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00424 | DB01019 | 19 | 427 | [
"DDInter896",
"DDInter199"
] | Hyoscyamine | Bethanechol | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For exampl... | Moderate | 1 | [
[
[
19,
24,
427
]
],
[
[
19,
6,
2720
],
[
2720,
45,
427
]
],
[
[
19,
21,
29316
],
[
29316,
60,
427
]
],
[
[
19,
24,
1442
],
[
1442,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bethanechol"
]
],
[
[
"Hyoscyamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM3"
],
[
"CHRM3",
"{u} (Gene) is bound by {v} (Compound)"... | Hyoscyamine (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Bethanechol (Compound)
Hyoscyamine (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Bethanechol (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Sc... |
DB00584 | DB11827 | 610 | 433 | [
"DDInter638",
"DDInter669"
] | Enalapril | Ertugliflozin | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
610,
24,
433
]
],
[
[
610,
24,
959
],
[
959,
24,
433
]
],
[
[
610,
63,
251
],
[
251,
24,
433
]
],
[
[
610,
1,
954
],
[
954,
24,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Beta... |
DB00502 | DB00757 | 1,300 | 1,166 | [
"DDInter853",
"DDInter581"
] | Haloperidol | Dolasetron | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1300,
25,
1166
]
],
[
[
1300,
63,
19
],
[
19,
40,
1166
]
],
[
[
1300,
24,
85
],
[
85,
1,
1166
]
],
[
[
1300,
6,
12523
],
[
12523,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscya... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
... |
DB00030 | DB00451 | 1,685 | 542 | [
"DDInter934",
"DDInter1064"
] | Insulin human | Levothyroxine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
1685,
24,
542
]
],
[
[
1685,
24,
624
],
[
624,
1,
542
]
],
[
[
1685,
24,
88
],
[
88,
23,
542
]
],
[
[
1685,
24,
772
],
[
772,
62... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Levothyroxine (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol may cause a minor interaction that can l... |
DB00056 | DB01208 | 816 | 945 | [
"DDInter814",
"DDInter1705"
] | Gemtuzumab ozogamicin | Sparfloxacin | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
816,
23,
945
]
],
[
[
816,
23,
739
],
[
739,
1,
945
]
],
[
[
816,
24,
372
],
[
372,
23,
945
]
],
[
[
816,
25,
770
],
[
770,
24,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomeflo... | Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a min... |
DB00480 | DB14761 | 1,668 | 242 | [
"DDInter1035",
"DDInter1578"
] | Lenalidomide | Remdesivir | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1668,
24,
242
]
],
[
[
1668,
25,
467
],
[
467,
24,
242
]
],
[
[
1668,
24,
129
],
[
129,
24,
242
]
],
[
[
1668,
63,
482
],
[
482,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simvastatin"
],
[
"Simva... | Lenalidomide may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide ... |
DB00278 | DB09293 | 291 | 116 | [
"DDInter117",
"DDInter954"
] | Argatroban | Iodide I-131 | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
291,
24,
116
]
],
[
[
291,
24,
1004
],
[
1004,
63,
116
]
],
[
[
291,
25,
365
],
[
365,
24,
116
]
],
[
[
291,
64,
834
],
[
834,
2... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
],... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Argatroban may lead to a major life threatening interaction when taken with Dalteparin and Dalte... |
DB00060 | DB00069 | 912 | 367 | [
"DDInter947",
"DDInter946"
] | Interferon beta-1a | Interferon alfacon-1 | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Moderate | 1 | [
[
[
912,
24,
367
]
],
[
[
912,
24,
467
],
[
467,
63,
367
]
],
[
[
912,
63,
305
],
[
305,
24,
367
]
],
[
[
912,
24,
581
],
[
581,
24,... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"S... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when take... |
DB00431 | DB00574 | 1,503 | 121 | [
"DDInter1072",
"DDInter717"
] | Lindane | Fenfluramine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
1503,
24,
121
]
],
[
[
1503,
24,
479
],
[
479,
62,
121
]
],
[
[
1503,
24,
958
],
[
958,
63,
121
]
],
[
[
1503,
63,
421
],
[
421,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
"... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Fenfluramine
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba and Ginkgo bilo... |
DB01222 | DB06710 | 617 | 1,546 | [
"DDInter246",
"DDInter1193"
] | Budesonide | Methyltestosterone | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
617,
24,
1546
]
],
[
[
617,
40,
1581
],
[
1581,
1,
1546
]
],
[
[
617,
63,
312
],
[
312,
1,
1546
]
],
[
[
617,
24,
984
],
[
984,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Budesonide",
"{u} (Compound) resembles {v} (Compound)",
"Testolactone"
],
[
"Testolactone",
"{u} (Compou... | Budesonide (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Methyltestosterone (Compound)
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone (Compound) resembles Methyltestosterone (Compound)
Budesonide may cause a moder... |
DB00446 | DB01415 | 597 | 1,521 | [
"DDInter351",
"DDInter331"
] | Chloramphenicol | Ceftibuten | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Ceftibuten is a third-generation cephalosporin antibiotic that is orally-administered. It is typically used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. | Moderate | 1 | [
[
[
597,
24,
1521
]
],
[
[
597,
24,
665
],
[
665,
40,
1521
]
],
[
[
597,
24,
1145
],
[
1145,
1,
1521
]
],
[
[
597,
63,
149
],
[
149,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftibuten"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
]... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Ceftibuten (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefdinir and Cefdinir (Compound) resembles Ceftibuten (Comp... |
DB08918 | DB12500 | 41 | 283 | [
"DDInter1059",
"DDInter714"
] | Levomilnacipran | Fedratinib | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
41,
24,
283
]
],
[
[
41,
63,
885
],
[
885,
24,
283
]
],
[
[
41,
64,
1133
],
[
1133,
24,
283
]
],
[
[
41,
63,
1564
],
[
1564,
25,... | [
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
... | Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Levomilnacipran may lead to a major life threatening interaction when taken with Granisetron and Granis... |
DB10276 | DB12267 | 1,624 | 1,476 | [
"DDInter1623",
"DDInter233"
] | Rotavirus vaccine | Brigatinib | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
1624,
25,
1476
]
],
[
[
1624,
64,
168
],
[
168,
23,
1476
]
],
[
[
1624,
64,
629
],
[
629,
24,
1476
]
],
[
[
1624,
25,
1456
],
[
1456,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib"... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Rotavirus vaccine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a mod... |
DB00609 | DB06674 | 595 | 908 | [
"DDInter694",
"DDInter837"
] | Ethionamide | Golimumab | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
595,
24,
908
]
],
[
[
595,
63,
268
],
[
268,
24,
908
]
],
[
[
595,
24,
458
],
[
458,
24,
908
]
],
[
[
595,
24,
1434
],
[
1434,
6... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
... | Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Ethionamide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01246 | DB09082 | 820 | 659 | [
"DDInter45",
"DDInter1934"
] | Alimemazine | Vilanterol | A phenothiazine derivative that is used as an antipruritic. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
820,
24,
659
]
],
[
[
820,
63,
1570
],
[
1570,
24,
659
]
],
[
[
820,
24,
1296
],
[
1296,
63,
659
]
],
[
[
820,
25,
1069
],
[
1069,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin deglude... |
DB00397 | DB00696 | 1,466 | 826 | [
"DDInter1458",
"DDInter665"
] | Phenylpropanolamine | Ergotamine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Major | 2 | [
[
[
1466,
25,
826
]
],
[
[
1466,
25,
469
],
[
469,
40,
826
]
],
[
[
1466,
64,
588
],
[
588,
1,
826
]
],
[
[
1466,
64,
1131
],
[
1131,
... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ergotamine"
]
],
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bromocriptine"
],
[
"Brom... | Phenylpropanolamine may lead to a major life threatening interaction when taken with Bromocriptine and Bromocriptine (Compound) resembles Ergotamine (Compound)
Phenylpropanolamine may lead to a major life threatening interaction when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergotamine (Co... |
DB00488 | DB14443 | 196 | 987 | [
"DDInter57",
"DDInter1931"
] | Altretamine | Vibrio cholerae CVD 103-HgR strain live antigen | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
196,
24,
987
]
],
[
[
196,
24,
259
],
[
259,
24,
987
]
],
[
[
196,
64,
581
],
[
581,
24,
987
]
],
[
[
196,
25,
1510
],
[
1510,
2... | [
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Altretamine may lead to a major life threatening interaction when taken wi... |
DB00668 | DB01577 | 874 | 1,529 | [
"DDInter652",
"DDInter1161"
] | Epinephrine | Metamfetamine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
874,
24,
1529
]
],
[
[
874,
24,
939
],
[
939,
40,
1529
]
],
[
[
874,
63,
80
],
[
80,
40,
1529
]
],
[
[
874,
24,
93
],
[
93,
1,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Metamfeta... |
DB01320 | DB12130 | 651 | 1,017 | [
"DDInter783",
"DDInter1094"
] | Fosphenytoin | Lorlatinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
651,
25,
1017
]
],
[
[
651,
62,
608
],
[
608,
23,
1017
]
],
[
[
651,
63,
590
],
[
590,
24,
1017
]
],
[
[
651,
25,
976
],
[
976,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Fosphenytoin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
"Lidocaine... | Fosphenytoin may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Aceto... |
DB01265 | DB08904 | 1,477 | 375 | [
"DDInter1757",
"DDInter342"
] | Telbivudine | Certolizumab pegol | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
1477,
24,
375
]
],
[
[
1477,
40,
231
],
[
231,
24,
375
]
],
[
[
1477,
24,
1047
],
[
1047,
24,
375
]
],
[
[
1477,
24,
1434
],
[
1434,
... | [
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Telbivudine",
"{u} (Compound) resembles {v} (Compound)",
"Stavudine"
],
[
"Stavudine",
"{u} may cause a... | Telbivudine (Compound) resembles Stavudine (Compound) and Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine and Trastuzumab emtansine may cause a m... |
DB11248 | DB13997 | 1,193 | 133 | [
"DDInter1965",
"DDInter163"
] | Zinc gluconate | Baloxavir marboxil | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wit... | Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of [baloxavir] with an improved absorption profile than its active metabolite due to the add... | Moderate | 1 | [
[
[
1193,
24,
133
]
],
[
[
1193,
23,
428
],
[
428,
63,
133
]
],
[
[
1193,
62,
1596
],
[
1596,
24,
133
]
],
[
[
1193,
23,
428
],
[
428,
... | [
[
[
"Zinc gluconate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baloxavir marboxil"
]
],
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ferrous fumar... | Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Baloxavir marboxil
Zinc gluconate may cause a minor interaction that can limit clinical effects when taken wi... |
DB00477 | DB01254 | 216 | 1,213 | [
"DDInter363",
"DDInter484"
] | Chlorpromazine | Dasatinib | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
216,
24,
1213
]
],
[
[
216,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
216,
7,
2023
],
[
2023,
46,
1213
]
],
[
[
216,
18,
8914
],
[
8914,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compou... | Chlorpromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Chlorpromazine (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Dasatinib (Compound)
Chlorpromazine (Compound) downregulates NUP85 (Gene) and NUP85 (Gene) is downregulated by Dasatinib (Compound)
Chl... |
DB00224 | DB09564 | 215 | 1,296 | [
"DDInter917",
"DDInter930"
] | Indinavir | Insulin degludec | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
215,
24,
1296
]
],
[
[
215,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
215,
25,
175
],
[
175,
24,
1296
]
],
[
[
215,
23,
303
],
[
303,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Indinavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolon... |
DB00011 | DB01098 | 1,451 | 14 | [
"DDInter944",
"DDInter1622"
] | Interferon alfa-n1 | Rosuvastatin | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
1451,
24,
14
]
],
[
[
1451,
24,
671
],
[
671,
24,
14
]
],
[
[
1451,
24,
1060
],
[
1060,
63,
14
]
],
[
[
1451,
63,
1057
],
[
1057,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastat... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with E... |
DB06707 | DB09241 | 584 | 1,629 | [
"DDInter1060",
"DDInter1186"
] | Levonordefrin | Methylene blue | Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Moderate | 1 | [
[
[
584,
24,
1629
]
],
[
[
584,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
584,
40,
1240
],
[
1240,
24,
1629
]
],
[
[
584,
1,
874
],
[
874,
... | [
[
[
"Levonordefrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylene blue"
]
],
[
[
"Levonordefrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
... | Levonordefrin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Levonordefrin (Compound) resembles Methoxamine (Compound) and Methoxamine may cause a moderate intera... |
DB01156 | DB06702 | 593 | 573 | [
"DDInter252",
"DDInter731"
] | Bupropion | Fesoterodine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
593,
24,
573
]
],
[
[
593,
62,
211
],
[
211,
1,
573
]
],
[
[
593,
6,
12523
],
[
12523,
45,
573
]
],
[
[
593,
21,
28681
],
[
28681,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Bupropion",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
],
[
... | Bupropion may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Bupropion (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound)
Bupropion (Compound) causes Hypersensitivity (Side Effect) and H... |
DB00501 | DB06016 | 752 | 1,508 | [
"DDInter380",
"DDInter300"
] | Cimetidine | Cariprazine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
752,
24,
1508
]
],
[
[
752,
25,
1213
],
[
1213,
24,
1508
]
],
[
[
752,
25,
1250
],
[
1250,
63,
1508
]
],
[
[
752,
24,
761
],
[
761,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib"... | Cimetidine may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Cimetidine may lead to a major life threatening interaction when taken with Pazopanib and Pazopanib may cause a moderate interac... |
DB00339 | DB09268 | 1,182 | 1,662 | [
"DDInter1547",
"DDInter1464"
] | Pyrazinamide | Picosulfuric acid | A pyrazine that is used therapeutically as an antitubercular agent. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1182,
24,
1662
]
],
[
[
1182,
63,
912
],
[
912,
24,
1662
]
],
[
[
1182,
24,
322
],
[
322,
24,
1662
]
],
[
[
1182,
63,
912
],
[
912,
... | [
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-... | Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken... |
DB00046 | DB09043 | 1,179 | 135 | [
"DDInter940",
"DDInter36"
] | Insulin lispro | Albiglutide | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1179,
24,
135
]
],
[
[
1179,
23,
1103
],
[
1103,
23,
135
]
],
[
[
1179,
24,
624
],
[
624,
24,
135
]
],
[
[
1179,
25,
646
],
[
646,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Insulin lispro",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liot... |
DB00263 | DB00907 | 1,029 | 290 | [
"DDInter1727",
"DDInter427"
] | Sulfisoxazole | Cocaine (topical) | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
1029,
24,
290
]
],
[
[
1029,
6,
6017
],
[
6017,
45,
290
]
],
[
[
1029,
1,
1247
],
[
1247,
6,
3486
],
[
3486,
45,
290
]
],
[
[
1029,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Sulfisoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Sulfisoxazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cocaine (Compound)
Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole (Compound) binds CYP2C8 (Gene) and CYP2C... |
DB01234 | DB06292 | 1,220 | 549 | [
"DDInter513",
"DDInter474"
] | Dexamethasone | Dapagliflozin | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1220,
24,
549
]
],
[
[
1220,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1220,
6,
9842
],
[
9842,
45,
549
]
],
[
[
1220,
21,
28882
],
[
28882... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Dexamethasone (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dapagliflozin (Compound)
Dexamethasone (Compound) causes Body temperature... |
DB05154 | DB12130 | 740 | 1,017 | [
"DDInter1517",
"DDInter1094"
] | Pretomanid | Lorlatinib | Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy re... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
740,
25,
1017
]
],
[
[
740,
24,
1450
],
[
1450,
24,
1017
]
],
[
[
740,
64,
1220
],
[
1220,
25,
1017
]
],
[
[
740,
25,
129
],
[
129,
... | [
[
[
"Pretomanid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Pretomanid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
"Empagli... | Pretomanid may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Pretomanid may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethason... |
DB00054 | DB00682 | 1,432 | 126 | [
"DDInter6",
"DDInter1951"
] | Abciximab | Warfarin | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Major | 2 | [
[
[
1432,
25,
126
]
],
[
[
1432,
23,
944
],
[
944,
62,
126
]
],
[
[
1432,
24,
477
],
[
477,
62,
126
]
],
[
[
1432,
24,
557
],
[
557,
... | [
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
]
],
[
[
"Abciximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Abciximab may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Warfarin
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may c... |
DB00393 | DB11827 | 854 | 433 | [
"DDInter1295",
"DDInter669"
] | Nimodipine | Ertugliflozin | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
854,
24,
433
]
],
[
[
854,
1,
1428
],
[
1428,
24,
433
]
],
[
[
854,
24,
820
],
[
820,
24,
433
]
],
[
[
854,
63,
999
],
[
999,
24... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Nimodipine",
"{u} (Compound) resembles {v} (Compound)",
"Isradipine"
],
[
"Isradipine",
"{u} may cause a mode... | Nimodipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that ... |
DB00530 | DB00705 | 1,195 | 441 | [
"DDInter667",
"DDInter496"
] | Erlotinib | Delavirdine | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
1195,
24,
441
]
],
[
[
1195,
6,
12523
],
[
12523,
45,
441
]
],
[
[
1195,
21,
28709
],
[
28709,
60,
441
]
],
[
[
1195,
24,
868
],
[
868... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Erlotinib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Delavirdine (Compound)
Erlotinib (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Ve... |
DB08875 | DB08896 | 1,618 | 292 | [
"DDInter262",
"DDInter1576"
] | Cabozantinib | Regorafenib | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
1618,
25,
292
]
],
[
[
1618,
64,
79
],
[
79,
1,
292
]
],
[
[
1618,
23,
1135
],
[
1135,
62,
292
]
],
[
[
1618,
63,
643
],
[
643,
... | [
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sorafenib"
],
[
"Sorafenib",
"{u... | Cabozantinib may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Cabozantinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effec... |
DB00397 | DB00983 | 1,466 | 480 | [
"DDInter1458",
"DDInter776"
] | Phenylpropanolamine | Formoterol | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1466,
24,
480
]
],
[
[
1466,
24,
1148
],
[
1148,
63,
480
]
],
[
[
1466,
6,
1704
],
[
1704,
45,
480
]
],
[
[
1466,
18,
10375
],
[
10375... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenal... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Phenylpropanolamine (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Formoterol (Compound... |
DB00581 | DB04868 | 355 | 478 | [
"DDInter1018",
"DDInter1293"
] | Lactulose | Nilotinib | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
355,
24,
478
]
],
[
[
355,
21,
28750
],
[
28750,
60,
478
]
],
[
[
355,
24,
1486
],
[
1486,
24,
478
]
],
[
[
355,
23,
1384
],
[
1384,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Lactulose",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal discomfort"
],
[
"Abdominal discomfort",
"{u} (S... | Lactulose (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Nilotinib (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerba... |
DB01069 | DB06204 | 401 | 768 | [
"DDInter1533",
"DDInter1746"
] | Promethazine | Tapentadol | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Moderate | 1 | [
[
[
401,
24,
768
]
],
[
[
401,
6,
12523
],
[
12523,
45,
768
]
],
[
[
401,
21,
28921
],
[
28921,
60,
768
]
],
[
[
401,
63,
1123
],
[
1123,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tapentadol"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Promethazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tapentadol (Compound)
Promethazine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Tapentadol (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline... |
DB00816 | DB08882 | 1,674 | 1,281 | [
"DDInter1346",
"DDInter1070"
] | Orciprenaline | Linagliptin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1674,
24,
1281
]
],
[
[
1674,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1674,
21,
28762
],
[
28762,
60,
1281
]
],
[
[
1674,
24,
1529
],
[
1... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Orciprenaline (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Linagliptin (Compound)
Orciprenaline may cause a moderate int... |
DB00562 | DB00804 | 1,014 | 1,507 | [
"DDInter188",
"DDInter543"
] | Benzthiazide | Dicyclomine | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Minor | 0 | [
[
[
1014,
23,
1507
]
],
[
[
1014,
40,
674
],
[
674,
62,
1507
]
],
[
[
1014,
1,
359
],
[
359,
62,
1507
]
],
[
[
1014,
1,
323
],
[
323,
... | [
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dicyclomine"
]
],
[
[
"Benzthiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiazide",
"{u} ... | Benzthiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Benzthiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a minor interaction that can limit clinical effects wh... |
DB08899 | DB08911 | 129 | 1,556 | [
"DDInter649",
"DDInter1842"
] | Enzalutamide | Trametinib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. ... | Moderate | 1 | [
[
[
129,
24,
1556
]
],
[
[
129,
6,
8374
],
[
8374,
45,
1556
]
],
[
[
129,
21,
29034
],
[
29034,
60,
1556
]
],
[
[
129,
25,
384
],
[
384,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trametinib"
]
],
[
[
"Enzalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Enzalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trametinib (Compound)
Enzalutamide (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Trametinib (Compound)
Enzalutamide may lead to a major life threatening interaction when taken with Id... |
DB00414 | DB00741 | 590 | 167 | [
"DDInter16",
"DDInter885"
] | Acetohexamide | Hydrocortisone | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
590,
24,
167
]
],
[
[
590,
24,
1220
],
[
1220,
40,
167
]
],
[
[
590,
24,
870
],
[
870,
1,
167
]
],
[
[
590,
24,
1561
],
[
1561,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resemb... |
DB00078 | DB00963 | 1,172 | 1,263 | [
"DDInter898",
"DDInter242"
] | Ibritumomab tiuxetan | Bromfenac (ophthalmic) | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Bromfenac is amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns ov... | Moderate | 1 | [
[
[
1172,
37,
1263
]
],
[
[
1172,
25,
935
],
[
935,
40,
1263
]
],
[
[
1172,
24,
282
],
[
282,
40,
1263
]
],
[
[
1172,
25,
1512
],
[
1512,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Bromfenac"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Bromfenac
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprof... |
DB05294 | DB14509 | 1,069 | 1,399 | [
"DDInter1917",
"DDInter1081"
] | Vandetanib | Lithium carbonate | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
1069,
25,
1399
]
],
[
[
1069,
25,
1374
],
[
1374,
24,
1399
]
],
[
[
1069,
64,
820
],
[
820,
24,
1399
]
],
[
[
1069,
24,
144
],
[
144,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",
... | Vandetanib may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Vandetanib may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a mo... |
DB00204 | DB01069 | 228 | 401 | [
"DDInter580",
"DDInter1533"
] | Dofetilide | Promethazine | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Major | 2 | [
[
[
228,
25,
401
]
],
[
[
228,
25,
1264
],
[
1264,
63,
401
]
],
[
[
228,
24,
1376
],
[
1376,
63,
401
]
],
[
[
228,
21,
28787
],
[
28787,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
]
],
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
],
[
"Doxepin",
"{u} may c... | Dofetilide may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Dofetilide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may ... |
DB01069 | DB01599 | 401 | 1,232 | [
"DDInter1533",
"DDInter1523"
] | Promethazine | Probucol | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
401,
24,
1232
]
],
[
[
401,
62,
112
],
[
112,
23,
1232
]
],
[
[
401,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
401,
24,
927
],
[
927,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and O... |
DB00069 | DB00361 | 367 | 134 | [
"DDInter946",
"DDInter1939"
] | Interferon alfacon-1 | Vinorelbine | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
367,
24,
134
]
],
[
[
367,
24,
147
],
[
147,
63,
134
]
],
[
[
367,
25,
1101
],
[
1101,
24,
134
]
],
[
[
367,
24,
599
],
[
599,
2... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinbla... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Interferon alfacon-1 may lead to a major life threatening interaction when taken with Bexarotene an... |
DB00773 | DB08867 | 896 | 807 | [
"DDInter702",
"DDInter1897"
] | Etoposide | Ulipristal | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Moderate | 1 | [
[
[
896,
24,
807
]
],
[
[
896,
63,
600
],
[
600,
23,
807
]
],
[
[
896,
24,
1017
],
[
1017,
63,
807
]
],
[
[
896,
24,
478
],
[
478,
2... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ulipristal"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Ulipristal
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatin... |
DB00065 | DB08860 | 581 | 788 | [
"DDInter923",
"DDInter1479"
] | Infliximab | Pitavastatin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
581,
24,
788
]
],
[
[
581,
24,
671
],
[
671,
1,
788
]
],
[
[
581,
24,
700
],
[
700,
40,
788
]
],
[
[
581,
24,
126
],
[
126,
23,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin (... |
DB00582 | DB09054 | 1,622 | 384 | [
"DDInter1946",
"DDInter905"
] | Voriconazole | Idelalisib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1622,
24,
384
]
],
[
[
1622,
25,
1618
],
[
1618,
24,
384
]
],
[
[
1622,
63,
305
],
[
305,
24,
384
]
],
[
[
1622,
24,
891
],
[
891,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabo... | Voriconazole may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia col... |
DB00939 | DB06754 | 1,338 | 707 | [
"DDInter1135",
"DDInter471"
] | Meclofenamic acid | Danaparoid | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
1338,
25,
707
]
],
[
[
1338,
63,
121
],
[
121,
24,
707
]
],
[
[
1338,
24,
222
],
[
222,
24,
707
]
],
[
[
1338,
24,
738
],
[
738,
... | [
[
[
"Meclofenamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
[
... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Sib... |
DB00363 | DB00468 | 695 | 1,424 | [
"DDInter419",
"DDInter1557"
] | Clozapine | Quinine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Major | 2 | [
[
[
695,
25,
1424
]
],
[
[
695,
6,
6017
],
[
6017,
45,
1424
]
],
[
[
695,
23,
112
],
[
112,
62,
1424
]
],
[
[
695,
24,
752
],
[
752,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Quinine"
... | Clozapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quinine (Compound)
Clozapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Quinine
Clozapine may cause a mo... |
DB00738 | DB11730 | 485 | 351 | [
"DDInter1420",
"DDInter1588"
] | Pentamidine | Ribociclib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
485,
25,
351
]
],
[
[
485,
23,
1247
],
[
1247,
23,
351
]
],
[
[
485,
24,
479
],
[
479,
23,
351
]
],
[
[
485,
63,
355
],
[
355,
2... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB00209 | DB00863 | 352 | 1,194 | [
"DDInter1886",
"DDInter1568"
] | Trospium | Ranitidine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Moderate | 1 | [
[
[
352,
24,
1194
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1194
]
],
[
[
352,
21,
28658
],
[
28658,
60,
1194
]
],
[
[
352,
24,
1664
],
[
166... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
]
],
[
[
"Trospium",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ranitidine (Compound)
Trospium (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Ranitidine (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone... |
DB01267 | DB08824 | 519 | 591 | [
"DDInter1381",
"DDInter959"
] | Paliperidone | Ioflupane I-123 | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
519,
24,
591
]
],
[
[
519,
21,
29305
],
[
29305,
60,
591
]
],
[
[
519,
40,
924
],
[
924,
24,
591
]
],
[
[
519,
63,
401
],
[
401,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Paliperidone",
"{u} (Compound) causes {v} (Side Effect)",
"Dysgeusia"
],
[
"Dysgeusia",
"{u} (Side Effect... | Paliperidone (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Paliperidone (Compound) resembles Iloperidone (Compound) and Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Paliperidone may cause a mod... |
DB00555 | DB01131 | 706 | 1,243 | [
"DDInter1020",
"DDInter1531"
] | Lamotrigine | Proguanil | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. | Minor | 0 | [
[
[
706,
23,
1243
]
],
[
[
706,
21,
28658
],
[
28658,
60,
1243
]
],
[
[
706,
77,
929
],
[
929,
24,
1243
]
],
[
[
706,
21,
28658
],
[
28658... | [
[
[
"Lamotrigine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Proguanil"
]
],
[
[
"Lamotrigine",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused ... | Lamotrigine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Proguanil (Compound)
Lamotrigine (Compound) resembles Pyrimethamine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Pyrimethamine and Pyrimethamine may cause a moderate i... |
DB01072 | DB09039 | 915 | 1,670 | [
"DDInter129",
"DDInter629"
] | Atazanavir | Eliglustat | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
915,
25,
1670
]
],
[
[
915,
25,
1135
],
[
1135,
62,
1670
]
],
[
[
915,
24,
1409
],
[
1409,
24,
1670
]
],
[
[
915,
24,
1499
],
[
1499,
... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Atazanavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a modera... |
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