drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00041 | DB00590 | 1,648 | 1,433 | [
"DDInter38",
"DDInter592"
] | Aldesleukin | Doxazosin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | Moderate | 1 | [
[
[
1648,
24,
1433
]
],
[
[
1648,
24,
195
],
[
195,
1,
1433
]
],
[
[
1648,
24,
1205
],
[
1205,
40,
1433
]
],
[
[
1648,
25,
593
],
[
593,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxazosin"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Terazosin and Terazosin (Compound) resembles Doxazosin (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Doxazosin (Compound)
Aldesl... |
DB01583 | DB06335 | 624 | 761 | [
"DDInter1075",
"DDInter1646"
] | Liotrix | Saxagliptin | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
624,
24,
761
]
],
[
[
624,
6,
16560
],
[
16560,
45,
761
]
],
[
[
624,
21,
28722
],
[
28722,
60,
761
]
],
[
[
624,
24,
1296
],
[
1296,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Liotrix",
"{u} (Compound) binds {v} (Gene)",
"SLC22A8"
],
[
"SLC22A8",
"{u} (Gene) is bound by {v} (Compound)",
... | Liotrix (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Saxagliptin (Compound)
Liotrix (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin d... |
DB00983 | DB06700 | 480 | 643 | [
"DDInter776",
"DDInter511"
] | Formoterol | Desvenlafaxine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
480,
24,
643
]
],
[
[
480,
63,
1100
],
[
1100,
1,
643
]
],
[
[
480,
21,
28975
],
[
28975,
60,
643
]
],
[
[
480,
63,
1636
],
[
1636,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Formoterol (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Desvenlafaxine (Compound)
Formoterol may cause a moderate intera... |
DB00461 | DB00798 | 598 | 1,132 | [
"DDInter1254",
"DDInter815"
] | Nabumetone | Gentamicin | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
598,
24,
1132
]
],
[
[
598,
21,
28703
],
[
28703,
60,
1132
]
],
[
[
598,
24,
1555
],
[
1555,
24,
1132
]
],
[
[
598,
24,
1662
],
[
1662... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Nabumetone",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused... | Nabumetone (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Gentami... |
DB01183 | DB11130 | 173 | 407 | [
"DDInter1262",
"DDInter1344"
] | Naloxone | Opium | Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
173,
24,
407
]
],
[
[
173,
63,
1454
],
[
1454,
24,
407
]
],
[
[
173,
24,
1301
],
[
1301,
24,
407
]
],
[
[
173,
24,
180
],
[
180,
... | [
[
[
"Naloxone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Naloxone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
],
[
"Sufe... | Naloxone may cause a moderate interaction that could exacerbate diseases when taken with Sufentanil and Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Opium
Naloxone may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol and Levacety... |
DB01284 | DB08908 | 1,042 | 713 | [
"DDInter1782",
"DDInter564"
] | Tetracosactide | Dimethyl fumarate | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1042,
24,
713
]
],
[
[
1042,
24,
4
],
[
4,
24,
713
]
],
[
[
1042,
24,
270
],
[
270,
63,
713
]
],
[
[
1042,
63,
589
],
[
589,
24,... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine ... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Tetracosactide may cause a moderate interaction that could exacerbate d... |
DB00674 | DB01177 | 1,516 | 77 | [
"DDInter802",
"DDInter904"
] | Galantamine | Idarubicin | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1516,
24,
77
]
],
[
[
1516,
6,
12523
],
[
12523,
45,
77
]
],
[
[
1516,
7,
11074
],
[
11074,
46,
77
]
],
[
[
1516,
21,
28931
],
[
28931... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Galantamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Galantamine (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Idarubicin (Compound)
Galantamine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)... |
DB00196 | DB06212 | 600 | 165 | [
"DDInter743",
"DDInter1833"
] | Fluconazole | Tolvaptan | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
600,
24,
165
]
],
[
[
600,
6,
8374
],
[
8374,
45,
165
]
],
[
[
600,
21,
28681
],
[
28681,
60,
165
]
],
[
[
600,
25,
1135
],
[
1135,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tolvaptan (Compound)
Fluconazole (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Tolvaptan (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Naloxegol and Nalox... |
DB01028 | DB01050 | 1,332 | 848 | [
"DDInter1179",
"DDInter900"
] | Methoxyflurane | Ibuprofen | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1332,
24,
848
]
],
[
[
1332,
6,
6017
],
[
6017,
45,
848
]
],
[
[
1332,
63,
91
],
[
91,
24,
848
]
],
[
[
1332,
24,
123
],
[
123,
... | [
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Methoxyflurane",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Comp... | Methoxyflurane (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ibuprofen (Compound)
Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Methoxyflura... |
DB00220 | DB00455 | 798 | 1,601 | [
"DDInter1276",
"DDInter1091"
] | Nelfinavir | Loratadine | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Moderate | 1 | [
[
[
798,
24,
1601
]
],
[
[
798,
6,
8374
],
[
8374,
45,
1601
]
],
[
[
798,
7,
7669
],
[
7669,
46,
1601
]
],
[
[
798,
21,
29106
],
[
29106,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loratadine (Compound)
Nelfinavir (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Loratadine (Compound)
Nelfinavir (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Loratadine (Compound)
Nelfinavir... |
DB00902 | DB01367 | 104 | 1,163 | [
"DDInter1168",
"DDInter1572"
] | Methdilazine | Rasagiline | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
104,
24,
1163
]
],
[
[
104,
63,
100
],
[
100,
24,
1163
]
],
[
[
104,
24,
401
],
[
401,
24,
1163
]
],
[
[
104,
1,
830
],
[
830,
6... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Prometh... |
DB00087 | DB00631 | 599 | 372 | [
"DDInter41",
"DDInter405"
] | Alemtuzumab | Clofarabine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
599,
24,
372
]
],
[
[
599,
24,
1426
],
[
1426,
40,
372
]
],
[
[
599,
25,
1064
],
[
1064,
25,
372
]
],
[
[
599,
24,
329
],
[
329,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Clofarabine (Compound)
Alemtuzumab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when... |
DB08816 | DB11703 | 578 | 405 | [
"DDInter1802",
"DDInter9"
] | Ticagrelor | Acalabrutinib | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
578,
25,
405
]
],
[
[
578,
63,
1051
],
[
1051,
24,
405
]
],
[
[
578,
24,
951
],
[
951,
24,
405
]
],
[
[
578,
24,
982
],
[
982,
6... | [
[
[
"Ticagrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
"... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Palb... |
DB01197 | DB06203 | 1,603 | 1,002 | [
"DDInter292",
"DDInter51"
] | Captopril | Alogliptin | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1603,
24,
1002
]
],
[
[
1603,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1603,
6,
12523
],
[
12523,
45,
1002
]
],
[
[
1603,
21,
28873
],
[
... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Captopril (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Alogliptin (Compound)
Captopril (Compound) causes Pancreatitis (Side Effect) and Pancrea... |
DB00814 | DB12332 | 1,171 | 1,619 | [
"DDInter1143",
"DDInter1626"
] | Meloxicam | Rucaparib | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1171,
24,
1619
]
],
[
[
1171,
24,
222
],
[
222,
23,
1619
]
],
[
[
1171,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
1171,
25,
1213
],
[
1213... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Pi... |
DB00041 | DB00193 | 1,648 | 534 | [
"DDInter38",
"DDInter1841"
] | Aldesleukin | Tramadol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Major | 2 | [
[
[
1648,
25,
534
]
],
[
[
1648,
24,
1100
],
[
1100,
40,
534
]
],
[
[
1648,
24,
1376
],
[
1376,
63,
534
]
],
[
[
1648,
25,
770
],
[
770,
... | [
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
"Venlafaxi... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Tramadol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interactio... |
DB06788 | DB09082 | 1,616 | 659 | [
"DDInter864",
"DDInter1934"
] | Histrelin | Vilanterol | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1616,
24,
659
]
],
[
[
1616,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1616,
24,
1296
],
[
1296,
63,
659
]
],
[
[
1616,
64,
1069
],
[
1069,... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
... | Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec an... |
DB00934 | DB11901 | 413 | 913 | [
"DDInter1124",
"DDInter107"
] | Maprotiline | Apalutamide | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
413,
24,
913
]
],
[
[
413,
62,
112
],
[
112,
23,
913
]
],
[
[
413,
63,
600
],
[
600,
24,
913
]
],
[
[
413,
24,
609
],
[
609,
24,... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Maprotiline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB00685 | DB01575 | 1,299 | 1,054 | [
"DDInter1887",
"DDInter1005"
] | Trovafloxacin | Kaolin | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1299,
24,
1054
]
],
[
[
1299,
1,
739
],
[
739,
24,
1054
]
],
[
[
1299,
63,
475
],
[
475,
24,
1054
]
],
[
[
1299,
1,
739
],
[
739,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u} may cause a m... | Trovafloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that cou... |
DB00405 | DB00761 | 128 | 1,621 | [
"DDInter517",
"DDInter1497"
] | Dexbrompheniramine | Potassium chloride | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
128,
25,
1621
]
],
[
[
128,
63,
1105
],
[
1105,
25,
1621
]
],
[
[
128,
24,
667
],
[
667,
64,
1621
]
],
[
[
128,
24,
1408
],
[
1408,
... | [
[
[
"Dexbrompheniramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl may lead to a major life threatening interaction when taken with Potassium chloride
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with So... |
DB01059 | DB01087 | 956 | 1,520 | [
"DDInter1313",
"DDInter1520"
] | Norfloxacin | Primaquine | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
956,
24,
1520
]
],
[
[
956,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
956,
6,
7950
],
[
7950,
45,
1520
]
],
[
[
956,
21,
28722
],
[
28722,... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"... | Norfloxacin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Norfloxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Primaquine (Compound)
Norfloxacin (Compound) causes ... |
DB06168 | DB11248 | 1,531 | 1,193 | [
"DDInter281",
"DDInter1965"
] | Canakinumab | Zinc gluconate | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
1531,
23,
1193
]
],
[
[
1531,
63,
1096
],
[
1096,
23,
1193
]
],
[
[
1531,
25,
725
],
[
725,
62,
1193
]
],
[
[
1531,
24,
270
],
[
270,
... | [
[
[
"Canakinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Canakinumab may lead to a major life threatening interaction when taken with Satralizumab and S... |
DB06616 | DB14444 | 594 | 151 | [
"DDInter224",
"DDInter924"
] | Bosutinib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
594,
24,
151
]
],
[
[
594,
63,
66
],
[
66,
24,
151
]
],
[
[
594,
24,
1619
],
[
1619,
24,
151
]
],
[
[
594,
25,
375
],
[
375,
24,... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exa... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Bosutinib may cause a moderate interac... |
DB00005 | DB00622 | 1,057 | 1,081 | [
"DDInter687",
"DDInter1287"
] | Etanercept | Nicardipine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Moderate | 1 | [
[
[
1057,
24,
1081
]
],
[
[
1057,
24,
409
],
[
409,
1,
1081
]
],
[
[
1057,
25,
1583
],
[
1583,
63,
1081
]
],
[
[
1057,
24,
1593
],
[
1593,... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicardipine"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Nicardipine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Sarilumab and Sarilumab may cause a moderate interaction that could exacerbate dise... |
DB01579 | DB09241 | 341 | 1,629 | [
"DDInter1439",
"DDInter1186"
] | Phendimetrazine | Methylene blue | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
341,
25,
1629
]
],
[
[
341,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
341,
24,
659
],
[
659,
24,
1629
]
],
[
[
341,
64,
73
],
[
73,
... | [
[
[
"Phendimetrazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Vil... |
DB01041 | DB01357 | 770 | 890 | [
"DDInter1789",
"DDInter1160"
] | Thalidomide | Mestranol | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Major | 2 | [
[
[
770,
25,
890
]
],
[
[
770,
25,
35
],
[
35,
40,
890
]
],
[
[
770,
64,
380
],
[
380,
40,
890
]
],
[
[
770,
63,
506
],
[
506,
1,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mestranol"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinestrol"
],
[
"Quinestrol",
"{u} ... | Thalidomide may lead to a major life threatening interaction when taken with Quinestrol and Quinestrol (Compound) resembles Mestranol (Compound)
Thalidomide may lead to a major life threatening interaction when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Mestranol (Compound)
Thalidomid... |
DB01410 | DB08873 | 423 | 74 | [
"DDInter375",
"DDInter221"
] | Ciclesonide | Boceprevir | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
423,
24,
74
]
],
[
[
423,
6,
8374
],
[
8374,
45,
74
]
],
[
[
423,
21,
28792
],
[
28792,
60,
74
]
],
[
[
423,
63,
86
],
[
86,
24,... | [
[
[
"Ciclesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Ciclesonide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Ciclesonide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Ciclesonide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Boceprevir (Compound)
Ciclesonide may cause a moderate interaction that could exacerbate diseases ... |
DB11730 | DB11760 | 351 | 119 | [
"DDInter1588",
"DDInter1742"
] | Ribociclib | Talazoparib | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
351,
24,
119
]
],
[
[
351,
63,
66
],
[
66,
24,
119
]
],
[
[
351,
64,
441
],
[
441,
24,
119
]
],
[
[
351,
24,
1129
],
[
1129,
63,... | [
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
],
[
... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Ribociclib may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cau... |
DB00515 | DB00734 | 589 | 1,664 | [
"DDInter387",
"DDInter1605"
] | Cisplatin | Risperidone | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
589,
24,
1664
]
],
[
[
589,
24,
519
],
[
519,
40,
1664
]
],
[
[
589,
6,
4973
],
[
4973,
45,
1664
]
],
[
[
589,
21,
28787
],
[
28787,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Risperidone (Compound)
Cisplatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Risperidone (Compound)
Cisplatin (Compound) causes Dermatitis (Side Effect) and Dermati... |
DB00757 | DB09472 | 1,166 | 1,383 | [
"DDInter581",
"DDInter1693"
] | Dolasetron | Sodium sulfate | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Major | 2 | [
[
[
1166,
25,
1383
]
],
[
[
1166,
25,
1482
],
[
1482,
23,
1383
]
],
[
[
1166,
64,
1252
],
[
1252,
23,
1383
]
],
[
[
1166,
25,
609
],
[
609... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Digitoxin"
],
[
"Digitoxin",
"{u}... | Dolasetron may lead to a major life threatening interaction when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Dolasetron may lead to a major life threatening interaction when taken with Digoxin and Digoxin may cause a minor interaction t... |
DB00554 | DB00635 | 1,027 | 1,573 | [
"DDInter1478",
"DDInter1515"
] | Piroxicam | Prednisone | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
1027,
24,
1573
]
],
[
[
1027,
24,
175
],
[
175,
40,
1573
]
],
[
[
1027,
63,
251
],
[
251,
1,
1573
]
],
[
[
1027,
24,
167
],
[
167,
... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Prednisone (... |
DB00279 | DB00655 | 1,152 | 559 | [
"DDInter1074",
"DDInter682"
] | Liothyronine | Estrone | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Moderate | 1 | [
[
[
1152,
24,
559
]
],
[
[
1152,
24,
35
],
[
35,
40,
559
]
],
[
[
1152,
24,
1438
],
[
1438,
1,
559
]
],
[
[
1152,
6,
4973
],
[
4973,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
[
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Estrone (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Estrone (Compound)
Liot... |
DB00047 | DB01367 | 176 | 1,163 | [
"DDInter932",
"DDInter1572"
] | Insulin glargine | Rasagiline | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
176,
24,
1163
]
],
[
[
176,
24,
590
],
[
590,
24,
1163
]
],
[
[
176,
23,
274
],
[
274,
24,
1163
]
],
[
[
176,
24,
659
],
[
659,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Phent... |
DB00188 | DB00995 | 168 | 1,112 | [
"DDInter222",
"DDInter139"
] | Bortezomib | Auranofin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Moderate | 1 | [
[
[
168,
24,
1112
]
],
[
[
168,
7,
5137
],
[
5137,
46,
1112
]
],
[
[
168,
18,
7379
],
[
7379,
57,
1112
]
],
[
[
168,
7,
3833
],
[
3833,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Auranofin"
]
],
[
[
"Bortezomib",
"{u} (Compound) upregulates {v} (Gene)",
"KDM5A"
],
[
"KDM5A",
"{u} (Gene) is upregulated by {v} (Co... | Bortezomib (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Auranofin (Compound)
Bortezomib (Compound) downregulates GALE (Gene) and GALE (Gene) is downregulated by Auranofin (Compound)
Bortezomib (Compound) upregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Auranofin (Compound)
Bortezo... |
DB00679 | DB01377 | 684 | 1,283 | [
"DDInter1796",
"DDInter1119"
] | Thioridazine | Magnesium oxide | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
684,
23,
1283
]
],
[
[
684,
40,
216
],
[
216,
23,
1283
]
],
[
[
684,
24,
167
],
[
167,
23,
1283
]
],
[
[
684,
64,
1018
],
[
1018,
... | [
[
[
"Thioridazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Thioridazine",
"{u} (Compound) resembles {v} (Compound)",
"Chlorpromazine"
],
[
"Chlorpromazine",
"{u} may ... | Thioridazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor in... |
DB00397 | DB01396 | 1,466 | 1,482 | [
"DDInter1458",
"DDInter553"
] | Phenylpropanolamine | Digitoxin | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
1466,
24,
1482
]
],
[
[
1466,
63,
1252
],
[
1252,
1,
1482
]
],
[
[
1466,
18,
2811
],
[
2811,
57,
1482
]
],
[
[
1466,
24,
1662
],
[
166... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Phenylpropanolamine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Digitoxin (Compound)
Phenylpropanolamine may cause a moderate i... |
DB01105 | DB01589 | 222 | 481 | [
"DDInter1665",
"DDInter1552"
] | Sibutramine | Quazepam | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
222,
24,
481
]
],
[
[
222,
63,
1216
],
[
1216,
1,
481
]
],
[
[
222,
24,
1418
],
[
1418,
1,
481
]
],
[
[
222,
63,
905
],
[
905,
4... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Quazepam (Compound)
Sibu... |
DB00603 | DB13928 | 303 | 1,385 | [
"DDInter1137",
"DDInter1660"
] | Medroxyprogesterone acetate | Semaglutide | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
303,
24,
1385
]
],
[
[
303,
63,
839
],
[
839,
24,
1385
]
],
[
[
303,
24,
637
],
[
637,
24,
1385
]
],
[
[
303,
25,
1476
],
[
1476,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate disea... |
DB00196 | DB00414 | 600 | 590 | [
"DDInter743",
"DDInter16"
] | Fluconazole | Acetohexamide | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Major | 2 | [
[
[
600,
25,
590
]
],
[
[
600,
24,
660
],
[
660,
62,
590
]
],
[
[
600,
24,
1017
],
[
1017,
63,
590
]
],
[
[
600,
25,
651
],
[
651,
6... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetohexamide"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
],
[
"Eso... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and... |
DB01166 | DB01611 | 477 | 1,487 | [
"DDInter379",
"DDInter893"
] | Cilostazol | Hydroxychloroquine | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
477,
25,
1487
]
],
[
[
477,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
477,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
477,
21,
28658
],
[
2865... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"Pr... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Cilostazol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Cilostazol (Compo... |
DB00279 | DB01396 | 1,152 | 1,482 | [
"DDInter1074",
"DDInter553"
] | Liothyronine | Digitoxin | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
1152,
24,
1482
]
],
[
[
1152,
24,
1252
],
[
1252,
1,
1482
]
],
[
[
1152,
6,
6648
],
[
6648,
45,
1482
]
],
[
[
1152,
7,
13230
],
[
1323... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Liothyronine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Digitoxin (Compound)
Liothyronine (Compound) upregulates TIPARP (Gene) and TIPARP (Gene) ... |
DB06228 | DB08918 | 792 | 41 | [
"DDInter1609",
"DDInter1059"
] | Rivaroxaban | Levomilnacipran | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
792,
24,
41
]
],
[
[
792,
63,
901
],
[
901,
40,
41
]
],
[
[
792,
6,
3792
],
[
3792,
45,
41
]
],
[
[
792,
18,
5901
],
[
5901,
57,... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Rivaroxaban (Compound) binds CYP2J2 (Gene) and CYP2J2 (Gene) is bound by Levomilnacipran (Compound)
Rivaroxaban (Compound) downregulates GJA1 (Gene) and... |
DB00880 | DB09020 | 359 | 28 | [
"DDInter360",
"DDInter212"
] | Chlorothiazide | Bisacodyl | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
359,
24,
28
]
],
[
[
359,
21,
28809
],
[
28809,
60,
28
]
],
[
[
359,
63,
870
],
[
870,
24,
28
]
],
[
[
359,
40,
674
],
[
674,
24... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Chlorothiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) ... | Chlorothiazide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound)
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when t... |
DB00549 | DB04835 | 522 | 1,655 | [
"DDInter1955",
"DDInter1125"
] | Zafirlukast | Maraviroc | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
522,
24,
1655
]
],
[
[
522,
6,
8374
],
[
8374,
45,
1655
]
],
[
[
522,
21,
28792
],
[
28792,
60,
1655
]
],
[
[
522,
24,
1419
],
[
1419,... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Maraviroc (Compound)
Zafirlukast (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Maraviroc (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases wh... |
DB00205 | DB08898 | 929 | 524 | [
"DDInter1550",
"DDInter828"
] | Pyrimethamine | Glucarpidase | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Glucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified _Escherichia coli_ bacteria. It is a 390-amino acid homodimer protein. High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades in treating various cancers; however, even with aggressive hydration, ... | Moderate | 1 | [
[
[
929,
24,
524
]
],
[
[
929,
24,
304
],
[
304,
24,
524
]
],
[
[
929,
24,
304
],
[
304,
1,
1548
],
[
1548,
24,
524
]
],
[
[
929,
6,... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glucarpidase"
]
],
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimetrexate"
]... | Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate and Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Glucarpidase
Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Trimetrex... |
DB00704 | DB00813 | 267 | 704 | [
"DDInter1263",
"DDInter722"
] | Naltrexone | Fentanyl | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Major | 2 | [
[
[
267,
25,
704
]
],
[
[
267,
25,
1322
],
[
1322,
40,
704
]
],
[
[
267,
24,
998
],
[
998,
1,
704
]
],
[
[
267,
25,
1454
],
[
1454,
... | [
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
]
],
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alfentanil"
],
[
"Alfentanil",
"{u} (Co... | Naltrexone may lead to a major life threatening interaction when taken with Alfentanil and Alfentanil (Compound) resembles Fentanyl (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Fentanyl (Compound)
Naltrexone ... |
DB01156 | DB01320 | 593 | 651 | [
"DDInter252",
"DDInter783"
] | Bupropion | Fosphenytoin | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
593,
24,
651
]
],
[
[
593,
63,
362
],
[
362,
1,
651
]
],
[
[
593,
64,
1048
],
[
1048,
40,
651
]
],
[
[
593,
6,
6017
],
[
6017,
4... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Bupropion may lead to a major life threatening interaction when taken with Doxapram and Doxapram (Compound) resembles Fosphenytoin (Compound)
Bupropion (Compound... |
DB00224 | DB00959 | 215 | 1,486 | [
"DDInter917",
"DDInter1191"
] | Indinavir | Methylprednisolone | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
215,
25,
1486
]
],
[
[
215,
25,
175
],
[
175,
40,
1486
]
],
[
[
215,
24,
167
],
[
167,
1,
1486
]
],
[
[
215,
63,
1351
],
[
1351,
... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone",
... | Indinavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednisolon... |
DB00005 | DB00791 | 1,057 | 132 | [
"DDInter687",
"DDInter1902"
] | Etanercept | Uracil mustard | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Major | 2 | [
[
[
1057,
25,
132
]
],
[
[
1057,
25,
970
],
[
970,
40,
132
]
],
[
[
1057,
24,
1430
],
[
1430,
63,
132
]
],
[
[
1057,
25,
259
],
[
259,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Uracil mustard"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluorouracil"
],
[
"Fluorouracil",
... | Etanercept may lead to a major life threatening interaction when taken with Fluorouracil and Fluorouracil (Compound) resembles Uracil mustard (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could ex... |
DB00196 | DB01041 | 600 | 770 | [
"DDInter743",
"DDInter1789"
] | Fluconazole | Thalidomide | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
600,
24,
770
]
],
[
[
600,
6,
7524
],
[
7524,
45,
770
]
],
[
[
600,
21,
28768
],
[
28768,
60,
770
]
],
[
[
600,
23,
609
],
[
609,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound... | Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Fluconazole (Compound) causes Acne (Side Effect) and Acne (Side Effect) is caused by Thalidomide (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarith... |
DB00215 | DB01168 | 1,230 | 1,053 | [
"DDInter388",
"DDInter1526"
] | Citalopram | Procarbazine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
1230,
25,
1053
]
],
[
[
1230,
24,
848
],
[
848,
40,
1053
]
],
[
[
1230,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1230,
24,
126
],
[
126... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibuprofen... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Citalopram (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Citalopram may cause a moderate interaction ... |
DB00594 | DB00741 | 863 | 167 | [
"DDInter68",
"DDInter885"
] | Amiloride | Hydrocortisone | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
863,
24,
167
]
],
[
[
863,
24,
1220
],
[
1220,
40,
167
]
],
[
[
863,
24,
870
],
[
870,
1,
167
]
],
[
[
863,
63,
251
],
[
251,
40... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydr... |
DB01105 | DB01176 | 222 | 537 | [
"DDInter1665",
"DDInter453"
] | Sibutramine | Cyclizine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
222,
24,
537
]
],
[
[
222,
63,
1242
],
[
1242,
24,
537
]
],
[
[
222,
24,
358
],
[
358,
24,
537
]
],
[
[
222,
62,
847
],
[
847,
1... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orp... |
DB00295 | DB01364 | 475 | 22 | [
"DDInter1244",
"DDInter650"
] | Morphine | Ephedrine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Minor | 0 | [
[
[
475,
23,
22
]
],
[
[
475,
21,
29494
],
[
29494,
60,
22
]
],
[
[
475,
25,
993
],
[
993,
62,
22
]
],
[
[
475,
24,
413
],
[
413,
23... | [
[
[
"Morphine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ephedrine"
]
],
[
[
"Morphine",
"{u} (Compound) causes {v} (Side Effect)",
"Delirium"
],
[
"Delirium",
"{u} (Side Effect) is caused by {v}... | Morphine (Compound) causes Delirium (Side Effect) and Delirium (Side Effect) is caused by Ephedrine (Compound)
Morphine may lead to a major life threatening interaction when taken with Diamorphine and Dia
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotilin... |
DB00496 | DB00804 | 194 | 1,507 | [
"DDInter480",
"DDInter543"
] | Darifenacin | Dicyclomine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
194,
24,
1507
]
],
[
[
194,
6,
2720
],
[
2720,
45,
1507
]
],
[
[
194,
21,
28817
],
[
28817,
60,
1507
]
],
[
[
194,
24,
1021
],
[
1021,... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Darifenacin",
"{u} (Compound) binds {v} (Gene)",
"CHRM3"
],
[
"CHRM3",
"{u} (Gene) is bound by {v} (Compound)"... | Darifenacin (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Dicyclomine (Compound)
Darifenacin (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Dicyclomine (Compound)
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Pramli... |
DB00400 | DB09330 | 353 | 985 | [
"DDInter843",
"DDInter1352"
] | Griseofulvin | Osimertinib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
353,
24,
985
]
],
[
[
353,
62,
168
],
[
168,
23,
985
]
],
[
[
353,
24,
1478
],
[
1478,
24,
985
]
],
[
[
353,
63,
134
],
[
134,
2... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Griseofulvin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[... | Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaf... |
DB01197 | DB01240 | 1,603 | 885 | [
"DDInter292",
"DDInter657"
] | Captopril | Epoprostenol | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1603,
24,
885
]
],
[
[
1603,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1603,
5,
11573
],
[
11573,
49,
885
]
],
[
[
1603,
21,
28996
],
[
2899... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Captopril (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Epoprostenol (Compound)
Captopril (Compound) ... |
DB00749 | DB00927 | 59 | 1,559 | [
"DDInter699",
"DDInter712"
] | Etodolac | Famotidine | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Minor | 0 | [
[
[
59,
23,
1559
]
],
[
[
59,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
59,
63,
1274
],
[
1274,
23,
1559
]
],
[
[
59,
25,
1468
],
[
1468,
... | [
[
[
"Etodolac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Famotidine"
]
],
[
[
"Etodolac",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is caused by {v... | Etodolac (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Famotidine
... |
DB10316 | DB12001 | 334 | 564 | [
"DDInter1248",
"DDInter7"
] | Mumps virus strain B level jeryl lynn live antigen | Abemaciclib | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
334,
25,
564
]
],
[
[
334,
64,
58
],
[
58,
24,
564
]
],
[
[
334,
25,
351
],
[
351,
24,
564
]
],
[
[
334,
25,
1476
],
[
1476,
63,... | [
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when ... | Mumps virus strain B level jeryl lynn live antigen may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Mumps virus strain B level jeryl lynn live antigen may lead to a major life threatening ... |
DB00983 | DB14754 | 480 | 1,663 | [
"DDInter776",
"DDInter1697"
] | Formoterol | Solriamfetol | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label]. | Moderate | 1 | [
[
[
480,
24,
1663
]
],
[
[
480,
63,
1674
],
[
1674,
24,
1663
]
],
[
[
480,
24,
1148
],
[
1148,
24,
1663
]
],
[
[
480,
24,
1053
],
[
1053,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solriamfetol"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Solriamfetol
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline ... |
DB01142 | DB06589 | 1,264 | 1,250 | [
"DDInter593",
"DDInter1400"
] | Doxepin | Pazopanib | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1264,
24,
1250
]
],
[
[
1264,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
1264,
18,
19557
],
[
19557,
57,
1250
]
],
[
[
1264,
21,
29264
],
[
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Doxepin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Doxepin (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Pazopanib (Compound)
Doxepin (Compound) causes Rhinorrhoea (Side Effect) and Rhinorrhoea (Side Effect) is caused by Pazopanib (Compound)
Doxepin ... |
DB00563 | DB00773 | 663 | 896 | [
"DDInter1174",
"DDInter702"
] | Methotrexate | Etoposide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
663,
24,
896
]
],
[
[
663,
5,
11642
],
[
11642,
44,
896
]
],
[
[
663,
6,
10417
],
[
10417,
45,
896
]
],
[
[
663,
7,
7335
],
[
7335,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Methotrexate",
"{u} (Compound) treats {v} (Disease)",
"urinary bladder cancer"
],
[
"urinary bladder cancer",
"... | Methotrexate (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Etoposide (Compound)
Methotrexate (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Etoposide (Compound)
Methotrexate (Compound) upregulates LIG1 (Gene) and LIG1 (Gene) is upregulated by Etoposide... |
DB00771 | DB00804 | 262 | 1,507 | [
"DDInter397",
"DDInter543"
] | Clidinium | Dicyclomine | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
262,
24,
1507
]
],
[
[
262,
6,
2720
],
[
2720,
45,
1507
]
],
[
[
262,
23,
674
],
[
674,
62,
1507
]
],
[
[
262,
62,
1252
],
[
1252,
... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Clidinium",
"{u} (Compound) binds {v} (Gene)",
"CHRM3"
],
[
"CHRM3",
"{u} (Gene) is bound by {v} (Compound)",
... | Clidinium (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Dicyclomine (Compound)
Clidinium may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Clidiniu... |
DB00387 | DB00424 | 1,386 | 19 | [
"DDInter1528",
"DDInter896"
] | Procyclidine | Hyoscyamine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
1386,
24,
19
]
],
[
[
1386,
24,
85
],
[
85,
63,
19
]
],
[
[
1386,
6,
7420
],
[
7420,
45,
19
]
],
[
[
1386,
10,
11558
],
[
11558,
... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Procyclidine (Compound) binds CHRM4 (Gene) and CHRM4 (Gene) is bound by Hyoscyamine (Compound)
Procyclidine (Comp... |
DB00333 | DB04868 | 576 | 478 | [
"DDInter1166",
"DDInter1293"
] | Methadone | Nilotinib | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
576,
25,
478
]
],
[
[
576,
6,
6017
],
[
6017,
45,
478
]
],
[
[
576,
21,
28963
],
[
28963,
60,
478
]
],
[
[
576,
40,
307
],
[
307,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotinib"... | Methadone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Methadone (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Methadone (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinica... |
DB00039 | DB12332 | 1,253 | 1,619 | [
"DDInter1380",
"DDInter1626"
] | Palifermin | Rucaparib | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1253,
24,
1619
]
],
[
[
1253,
24,
309
],
[
309,
24,
1619
]
],
[
[
1253,
24,
975
],
[
975,
63,
1619
]
],
[
[
1253,
24,
351
],
[
351,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin and Lu... |
DB00207 | DB00358 | 1,570 | 1,010 | [
"DDInter157",
"DDInter1140"
] | Azithromycin | Mefloquine | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
1570,
24,
1010
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
1570,
21,
28789
],
[
28789,
60,
1010
]
],
[
[
1570,
23,
112
],
[
11... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Azithromycin (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Mefloquine (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when ta... |
DB00635 | DB11817 | 1,573 | 1,259 | [
"DDInter1515",
"DDInter165"
] | Prednisone | Baricitinib | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1573,
25,
1259
]
],
[
[
1573,
23,
1193
],
[
1193,
23,
1259
]
],
[
[
1573,
62,
1461
],
[
1461,
23,
1259
]
],
[
[
1573,
24,
1274
],
[
12... | [
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gl... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Prednisone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB00307 | DB09039 | 1,101 | 1,670 | [
"DDInter202",
"DDInter629"
] | Bexarotene | Eliglustat | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
1101,
24,
1670
]
],
[
[
1101,
24,
479
],
[
479,
23,
1670
]
],
[
[
1101,
24,
1135
],
[
1135,
62,
1670
]
],
[
[
1101,
24,
1409
],
[
1409... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol m... |
DB00208 | DB01404 | 1,018 | 757 | [
"DDInter1804",
"DDInter820"
] | Ticlopidine | Ginseng | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1018,
24,
757
]
],
[
[
1018,
63,
25
],
[
25,
24,
757
]
],
[
[
1018,
24,
578
],
[
578,
63,
757
]
],
[
[
1018,
25,
553
],
[
553,
2... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anistreplase"
],
[
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Tic... |
DB00224 | DB05351 | 215 | 101 | [
"DDInter917",
"DDInter519"
] | Indinavir | Dexlansoprazole | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
215,
24,
101
]
],
[
[
215,
25,
263
],
[
263,
62,
101
]
],
[
[
215,
23,
609
],
[
609,
24,
101
]
],
[
[
215,
24,
883
],
[
883,
24,... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
],
[
"Axitinib"... | Indinavir may lead to a major life threatening interaction when taken with Axitinib and Axitinib may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Indinavir may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may cau... |
DB06603 | DB08901 | 39 | 1,468 | [
"DDInter1387",
"DDInter1492"
] | Panobinostat | Ponatinib | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
39,
25,
1468
]
],
[
[
39,
64,
478
],
[
478,
24,
1468
]
],
[
[
39,
63,
752
],
[
752,
23,
1468
]
],
[
[
39,
24,
286
],
[
286,
62,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
"{u} ... | Panobinostat may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause... |
DB00060 | DB00982 | 912 | 1,517 | [
"DDInter947",
"DDInter991"
] | Interferon beta-1a | Isotretinoin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
912,
24,
1517
]
],
[
[
912,
24,
640
],
[
640,
25,
1517
]
],
[
[
912,
24,
362
],
[
362,
24,
1517
]
],
[
[
912,
24,
868
],
[
868,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acitretin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenyt... |
DB09407 | DB12147 | 853 | 241 | [
"DDInter1114",
"DDInter661"
] | Magnesium chloride | Erdafitinib | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Major | 2 | [
[
[
853,
25,
241
]
],
[
[
853,
63,
286
],
[
286,
25,
241
]
],
[
[
853,
24,
460
],
[
460,
25,
241
]
],
[
[
853,
24,
1473
],
[
1473,
6... | [
[
[
"Magnesium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erdafitinib"
]
],
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
... | Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may lead to a major life threatening interaction when taken with Erdafitinib
Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB01069 | DB01173 | 401 | 358 | [
"DDInter1533",
"DDInter1349"
] | Promethazine | Orphenadrine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
401,
35,
358
]
],
[
[
401,
63,
211
],
[
211,
1,
358
]
],
[
[
401,
24,
272
],
[
272,
24,
358
]
],
[
[
401,
1,
293
],
[
293,
40,
... | [
[
[
"Promethazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when t... | Promethazine (Compound) resembles Orphenadrine (Compound) and
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Orphenadrine (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00011 | DB00916 | 1,451 | 112 | [
"DDInter944",
"DDInter1202"
] | Interferon alfa-n1 | Metronidazole | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
1451,
24,
112
]
],
[
[
1451,
24,
458
],
[
458,
40,
112
]
],
[
[
1451,
24,
996
],
[
996,
62,
112
]
],
[
[
1451,
25,
695
],
[
695,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazo... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a minor inte... |
DB06228 | DB08912 | 792 | 1,040 | [
"DDInter1609",
"DDInter462"
] | Rivaroxaban | Dabrafenib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
792,
24,
1040
]
],
[
[
792,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
792,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
792,
24,
1612
],
[
1612,... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Rivaroxaban",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Rivaroxaban (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Rivaroxaban (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Fostemsa... |
DB00023 | DB00697 | 305 | 876 | [
"DDInter127",
"DDInter1821"
] | Asparaginase Escherichia coli | Tizanidine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Moderate | 1 | [
[
[
305,
24,
876
]
],
[
[
305,
25,
770
],
[
770,
63,
876
]
],
[
[
305,
24,
1374
],
[
1374,
63,
876
]
],
[
[
305,
24,
912
],
[
912,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tizanidine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thal... | Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Tizanidine
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00787 | DB14761 | 387 | 242 | [
"DDInter25",
"DDInter1578"
] | Acyclovir | Remdesivir | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
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]
],
[
[
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],
[
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[
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],
[
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]
],
[
[
387,
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372
],
[
372,
24,
... | [
[
[
"Acyclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Acyclovir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
],
[
"Sirolimus",
... | Acyclovir may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Acyclovir may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may caus... |
DB00703 | DB01001 | 997 | 688 | [
"DDInter1167",
"DDInter1632"
] | Methazolamide | Salbutamol | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
997,
24,
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]
],
[
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[
455,
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[
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[
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]
],
[
[
997,
21,
28714
],
[
28714,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Methazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Salbutamol (Compound)
Methazolamid... |
DB00865 | DB12010 | 939 | 214 | [
"DDInter187",
"DDInter785"
] | Benzphetamine | Fostamatinib | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
939,
24,
214
]
],
[
[
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],
[
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[
[
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],
[
307,
24,
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]
],
[
[
939,
24,
1130
],
[
1130,
2... | [
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Benzphetamine (Compound) resembles Modafinil (Compound) and Modafinil may cause a moderate interaction that... |
DB08895 | DB14444 | 976 | 151 | [
"DDInter1825",
"DDInter924"
] | Tofacitinib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
976,
24,
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]
],
[
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[
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[
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],
[
1619,
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]
],
[
[
976,
25,
994
],
[
994,
63,... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening intera... | Tofacitinib may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Tofacitinib may lead to a major life threatening in... |
DB00443 | DB09268 | 251 | 1,662 | [
"DDInter195",
"DDInter1464"
] | Betamethasone | Picosulfuric acid | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
251,
24,
1662
]
],
[
[
251,
24,
1482
],
[
1482,
23,
1662
]
],
[
[
251,
63,
1252
],
[
1252,
23,
1662
]
],
[
[
251,
24,
1619
],
[
1619,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and ... |
DB01126 | DB08820 | 1,260 | 1,478 | [
"DDInter611",
"DDInter997"
] | Dutasteride | Ivacaftor | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1260,
24,
1478
]
],
[
[
1260,
6,
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],
[
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45,
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[
[
1260,
21,
29998
],
[
29998,
60,
1478
]
],
[
[
1260,
24,
484
],
[
48... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Dutasteride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Dutasteride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Dutasteride (Compound) causes Hyperaesthesia (Side Effect) and Hyperaesthesia (Side Effect) is caused by Ivacaftor (Compound)
Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Entrecti... |
DB00603 | DB06674 | 303 | 908 | [
"DDInter1137",
"DDInter837"
] | Medroxyprogesterone acetate | Golimumab | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
303,
24,
908
]
],
[
[
303,
24,
697
],
[
697,
24,
908
]
],
[
[
303,
23,
14
],
[
14,
24,
908
]
],
[
[
303,
63,
362
],
[
362,
24,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects ... |
DB01118 | DB11967 | 33 | 710 | [
"DDInter76",
"DDInter210"
] | Amiodarone | Binimetinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
33,
24,
710
]
],
[
[
33,
25,
1593
],
[
1593,
24,
710
]
],
[
[
33,
24,
951
],
[
951,
24,
710
]
],
[
[
33,
64,
1557
],
[
1557,
24,... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotini... | Amiodarone may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cau... |
DB01128 | DB12010 | 918 | 214 | [
"DDInter204",
"DDInter785"
] | Bicalutamide | Fostamatinib | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
918,
24,
214
]
],
[
[
918,
63,
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],
[
723,
24,
214
]
],
[
[
918,
24,
861
],
[
861,
63,
214
]
],
[
[
918,
24,
866
],
[
866,
24,... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib and ... |
DB06603 | DB09075 | 39 | 498 | [
"DDInter1387",
"DDInter621"
] | Panobinostat | Edoxaban | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
39,
25,
498
]
],
[
[
39,
64,
109
],
[
109,
24,
498
]
],
[
[
39,
24,
1017
],
[
1017,
63,
498
]
],
[
[
39,
24,
1623
],
[
1623,
24,... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duloxetine"
],
[
"Duloxetine",
"{u}... | Panobinostat may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may caus... |
DB00349 | DB00736 | 902 | 660 | [
"DDInter401",
"DDInter676"
] | Clobazam | Esomeprazole | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Moderate | 1 | [
[
[
902,
24,
660
]
],
[
[
902,
24,
1215
],
[
1215,
40,
660
]
],
[
[
902,
6,
8374
],
[
8374,
45,
660
]
],
[
[
902,
21,
28785
],
[
28785,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
]
],
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
... | Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Esomeprazole (Compound)
Clobazam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Esomeprazole (Compound)
Clobazam (Compound) causes Muscle spasms (Side Effect) and Mus... |
DB01206 | DB11988 | 37 | 270 | [
"DDInter1086",
"DDInter1321"
] | Lomustine | Ocrelizumab | An alkylating agent of value against both hematologic malignancies and solid tumors. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
37,
24,
270
]
],
[
[
37,
63,
1461
],
[
1461,
23,
270
]
],
[
[
37,
63,
134
],
[
134,
24,
270
]
],
[
[
37,
24,
713
],
[
713,
24,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbin... |
DB01067 | DB01284 | 959 | 1,042 | [
"DDInter826",
"DDInter1782"
] | Glipizide | Tetracosactide | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
959,
24,
1042
]
],
[
[
959,
63,
455
],
[
455,
23,
1042
]
],
[
[
959,
24,
659
],
[
659,
62,
1042
]
],
[
[
959,
63,
461
],
[
461,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilant... |
DB01073 | DB10316 | 1,488 | 334 | [
"DDInter745",
"DDInter1248"
] | Fludarabine | Mumps virus strain B level jeryl lynn live antigen | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1488,
25,
334
]
],
[
[
1488,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1488,
63,
328
],
[
328,
25,
334
]
],
[
[
1488,
25,
908
],
[
908,
... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Fludarabine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptop... |
DB01259 | DB08820 | 392 | 1,478 | [
"DDInter1024",
"DDInter997"
] | Lapatinib | Ivacaftor | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
392,
24,
1478
]
],
[
[
392,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
392,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
392,
23,
907
],
[
907,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Lapatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Lapatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Lapatinib (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Lapatinib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravir... |
DB04896 | DB06704 | 901 | 247 | [
"DDInter1220",
"DDInter951"
] | Milnacipran | Iobenguane (I-123) | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
901,
37,
247
]
],
[
[
901,
6,
7390
],
[
7390,
45,
247
]
],
[
[
901,
21,
28787
],
[
28787,
60,
247
]
],
[
[
901,
24,
1090
],
[
1090,
... | [
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Milnacipran",
"{u} (Compound) binds {v} (Gene)",
"SLC6... | Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Milnacipran may lead to a major life threatening interaction when taken with Iobenguane
Milnacipran (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Milnacipran (Compound) causes ... |
DB00851 | DB14409 | 611 | 1,129 | [
"DDInter463",
"DDInter867"
] | Dacarbazine | Human adenovirus e serotype 4 strain cl-68578 antigen | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
611,
24,
1129
]
],
[
[
611,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
611,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
611,
63,
134
],
[
134,
... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Dacarbazine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Dacarbazine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00641 | DB08901 | 467 | 1,468 | [
"DDInter1675",
"DDInter1492"
] | Simvastatin | Ponatinib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
467,
24,
1468
]
],
[
[
467,
24,
478
],
[
478,
24,
1468
]
],
[
[
467,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
467,
7,
7478
],
[
7478,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Simvastatin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Simvastatin (Compoun... |
DB01169 | DB09078 | 57 | 1,228 | [
"DDInter120",
"DDInter1036"
] | Arsenic trioxide | Lenvatinib | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
57,
25,
1228
]
],
[
[
57,
62,
112
],
[
112,
23,
1228
]
],
[
[
57,
64,
1100
],
[
1100,
24,
1228
]
],
[
[
57,
25,
938
],
[
938,
63... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Arsenic trioxide may lead to a major life threatening interaction when taken with Venlafaxine and Venlaf... |
DB01083 | DB08886 | 1,142 | 637 | [
"DDInter1348",
"DDInter126"
] | Orlistat | Asparaginase Erwinia chrysanthemi | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1142,
24,
637
]
],
[
[
1142,
24,
5
],
[
5,
24,
637
]
],
[
[
1142,
24,
1385
],
[
1385,
63,
637
]
],
[
[
1142,
63,
1647
],
[
1647,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglut... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Orlistat may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01222 | DB11952 | 617 | 800 | [
"DDInter246",
"DDInter612"
] | Budesonide | Duvelisib | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
617,
24,
800
]
],
[
[
617,
63,
663
],
[
663,
24,
800
]
],
[
[
617,
24,
270
],
[
270,
63,
800
]
],
[
[
617,
24,
1683
],
[
1683,
2... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Oc... |
DB01276 | DB02701 | 123 | 1,632 | [
"DDInter706",
"DDInter1289"
] | Exenatide | Nicotinamide | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Moderate | 1 | [
[
[
123,
24,
1632
]
],
[
[
123,
24,
1254
],
[
1254,
24,
1632
]
],
[
[
123,
63,
176
],
[
176,
24,
1632
]
],
[
[
123,
24,
1412
],
[
1412,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicotinamide"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Nicotinamide
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Insulin... |
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