drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00995 | DB12834 | 1,112 | 148 | [
"DDInter139",
"DDInter1649"
] | Auranofin | Secnidazole | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1112,
24,
148
]
],
[
[
1112,
24,
1593
],
[
1593,
24,
148
]
],
[
[
1112,
63,
597
],
[
597,
24,
148
]
],
[
[
1112,
25,
1487
],
[
1487,
... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
... | Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Auranofin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Ch... |
DB00816 | DB06335 | 1,674 | 761 | [
"DDInter1346",
"DDInter1646"
] | Orciprenaline | Saxagliptin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1674,
24,
761
]
],
[
[
1674,
21,
28722
],
[
28722,
60,
761
]
],
[
[
1674,
63,
307
],
[
307,
23,
761
]
],
[
[
1674,
24,
1491
],
[
1491,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Orciprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is cau... | Orciprenaline (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Saxaglipti... |
DB00495 | DB01050 | 139 | 848 | [
"DDInter1961",
"DDInter900"
] | Zidovudine | Ibuprofen | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
139,
24,
848
]
],
[
[
139,
24,
1053
],
[
1053,
1,
848
]
],
[
[
139,
6,
1829
],
[
1829,
45,
848
]
],
[
[
139,
21,
28773
],
[
28773,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
[
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Zidovudine (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Zidovudine (Compound) causes Urethral disorder (Side Effect) and Ureth... |
DB00067 | DB00757 | 317 | 1,166 | [
"DDInter1921",
"DDInter581"
] | Vasopressin | Dolasetron | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
317,
25,
1166
]
],
[
[
317,
23,
112
],
[
112,
62,
1166
]
],
[
[
317,
24,
688
],
[
688,
63,
1166
]
],
[
[
317,
63,
521
],
[
521,
... | [
[
[
"Vasopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Dolasetron
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Sa... |
DB00682 | DB09052 | 126 | 250 | [
"DDInter1951",
"DDInter220"
] | Warfarin | Blinatumomab | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
126,
24,
250
]
],
[
[
126,
24,
1412
],
[
1412,
63,
250
]
],
[
[
126,
24,
637
],
[
637,
24,
250
]
],
[
[
126,
63,
305
],
[
305,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
],
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and Calaspargase pegol may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Asparag... |
DB00791 | DB14444 | 132 | 151 | [
"DDInter1902",
"DDInter924"
] | Uracil mustard | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
132,
24,
151
]
],
[
[
132,
24,
869
],
[
869,
24,
151
]
],
[
[
132,
25,
375
],
[
375,
24,
151
]
],
[
[
132,
64,
1066
],
[
1066,
2... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Uracil mustard may lead to a major ... |
DB01246 | DB11057 | 820 | 720 | [
"DDInter45",
"DDInter1223"
] | Alimemazine | Mineral oil | A phenothiazine derivative that is used as an antipruritic. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
820,
24,
720
]
],
[
[
820,
24,
927
],
[
927,
63,
720
]
],
[
[
820,
24,
1151
],
[
1151,
24,
720
]
],
[
[
820,
25,
1069
],
[
1069,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Su... |
DB08917 | DB14491 | 1,608 | 428 | [
"DDInter723",
"DDInter725"
] | Ferric carboxymaltose | Ferrous fumarate | Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013. | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
1608,
24,
428
]
],
[
[
1608,
63,
597
],
[
597,
24,
428
]
],
[
[
1608,
64,
1575
],
[
1575,
25,
428
]
],
[
[
1608,
63,
597
],
[
597,
... | [
[
[
"Ferric carboxymaltose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Ferric carboxymaltose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Ferric carboxymaltose may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate
Ferric carboxymaltose may lead to a major life threatening interaction when taken wit... |
DB00500 | DB09418 | 24 | 554 | [
"DDInter1831",
"DDInter1501"
] | Tolmetin | Potassium perchlorate | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Moderate | 1 | [
[
[
24,
24,
554
]
],
[
[
24,
40,
886
],
[
886,
24,
554
]
],
[
[
24,
24,
1274
],
[
1274,
24,
554
]
],
[
[
24,
1,
831
],
[
831,
24,
... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Tolmetin",
"{u} (Compound) resembles {v} (Compound)",
"Ketorolac"
],
[
"Ketorolac",
"{u} may cause a mo... | Tolmetin (Compound) resembles Ketorolac (Compound) and Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction t... |
DB01344 | DB14520 | 1,231 | 1,229 | [
"DDInter1830",
"DDInter1785"
] | Tolevamer | Tetraferric tricitrate decahydrate | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Moderate | 1 | [
[
[
1231,
24,
1229
]
],
[
[
1231,
63,
954
],
[
954,
24,
1229
]
],
[
[
1231,
24,
320
],
[
320,
24,
1229
]
],
[
[
1231,
63,
954
],
[
954,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quina... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Tetraferric tricitrate decahydrate
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00820 | DB01110 | 402 | 86 | [
"DDInter1736",
"DDInter1209"
] | Tadalafil | Miconazole | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
402,
24,
86
]
],
[
[
402,
6,
8374
],
[
8374,
45,
86
]
],
[
[
402,
21,
29122
],
[
29122,
60,
86
]
],
[
[
402,
63,
1101
],
[
1101,
... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Tadalafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tadalafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound)
Tadalafil (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01364 | DB09564 | 22 | 1,296 | [
"DDInter650",
"DDInter930"
] | Ephedrine | Insulin degludec | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
22,
24,
1296
]
],
[
[
22,
23,
1203
],
[
1203,
23,
1296
]
],
[
[
22,
63,
17
],
[
17,
24,
1296
]
],
[
[
22,
24,
659
],
[
659,
24,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Ephedrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Monopotassium phosphate"
... | Ephedrine may cause a minor interaction that can limit clinical effects when taken with Monopotassium phosphate and Monopotassium phosphate may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00969 | DB01182 | 2 | 371 | [
"DDInter52",
"DDInter1534"
] | Alosetron | Propafenone | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
2,
24,
371
]
],
[
[
2,
6,
6017
],
[
6017,
45,
371
]
],
[
[
2,
21,
28765
],
[
28765,
60,
371
]
],
[
[
2,
63,
752
],
[
752,
24,
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Alosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Alosetron (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Propafenone (Compound)
Alosetron (Compound) causes Abnormal dreams (Side Effect) and Abnormal dreams (Side Effect) is caused by Propafenone (Compound)
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Cimetidi... |
DB06674 | DB09330 | 908 | 985 | [
"DDInter837",
"DDInter1352"
] | Golimumab | Osimertinib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
908,
25,
985
]
],
[
[
908,
64,
168
],
[
168,
23,
985
]
],
[
[
908,
63,
112
],
[
112,
23,
985
]
],
[
[
908,
64,
134
],
[
134,
24,... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u} ma... | Golimumab may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cau... |
DB00295 | DB14575 | 475 | 733 | [
"DDInter1244",
"DDInter674"
] | Morphine | Eslicarbazepine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
475,
24,
733
]
],
[
[
475,
24,
1264
],
[
1264,
24,
733
]
],
[
[
475,
63,
1314
],
[
1314,
24,
733
]
],
[
[
475,
24,
124
],
[
124,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopres... |
DB00153 | DB00880 | 1,331 | 359 | [
"DDInter662",
"DDInter360"
] | Ergocalciferol | Chlorothiazide | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
1331,
24,
359
]
],
[
[
1331,
24,
1577
],
[
1577,
1,
359
]
],
[
[
1331,
21,
29209
],
[
29209,
60,
359
]
],
[
[
1331,
25,
1196
],
[
1196... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiaz... | Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Ergocalciferol (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound)
Ergocalciferol... |
DB01172 | DB06590 | 416 | 1,682 | [
"DDInter1004",
"DDInter329"
] | Kanamycin | Ceftaroline fosamil | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia. | Moderate | 1 | [
[
[
416,
24,
1682
]
],
[
[
416,
63,
149
],
[
149,
40,
1682
]
],
[
[
416,
63,
778
],
[
778,
1,
1682
]
],
[
[
416,
24,
1453
],
[
1453,
... | [
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftaroline fosamil"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftazidime"
],
... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Ceftaroline fosamil (Compound)
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Cefixime and Cefixime (Compound) resembles Ceftaroline fosam... |
DB06290 | DB11901 | 1,449 | 913 | [
"DDInter1673",
"DDInter107"
] | Simeprevir | Apalutamide | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1449,
25,
913
]
],
[
[
1449,
64,
600
],
[
600,
24,
913
]
],
[
[
1449,
63,
467
],
[
467,
24,
913
]
],
[
[
1449,
24,
1421
],
[
1421,
... | [
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fluconazole",
"{u... | Simeprevir may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may c... |
DB00598 | DB09112 | 1,523 | 1,455 | [
"DDInter1013",
"DDInter1306"
] | Labetalol | Nitrous acid | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1523,
24,
1455
]
],
[
[
1523,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
1523,
40,
954
],
[
954,
24,
1455
]
],
[
[
1523,
24,
433
],
[
433,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Labetalol (Compound) resembles Quinapril (Compound) and Quinapril may cause a moderate interaction that c... |
DB00708 | DB09065 | 1,454 | 760 | [
"DDInter1718",
"DDInter424"
] | Sufentanil | Cobicistat | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1454,
24,
760
]
],
[
[
1454,
63,
1101
],
[
1101,
23,
760
]
],
[
[
1454,
63,
723
],
[
723,
24,
760
]
],
[
[
1454,
24,
609
],
[
609,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepita... |
DB00081 | DB06168 | 273 | 1,531 | [
"DDInter1838",
"DDInter281"
] | Tositumomab | Canakinumab | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
273,
24,
1531
]
],
[
[
273,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
273,
25,
1213
],
[
1213,
24,
1531
]
],
[
[
273,
25,
1409
],
[
1409,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified prot... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Tositumomab may lead to a major life threatening inter... |
DB00405 | DB01452 | 128 | 993 | [
"DDInter517",
"DDInter532"
] | Dexbrompheniramine | Diamorphine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Moderate | 1 | [
[
[
128,
24,
993
]
],
[
[
128,
63,
421
],
[
421,
40,
993
]
],
[
[
128,
63,
475
],
[
475,
25,
993
]
],
[
[
128,
24,
13
],
[
13,
24,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diamorphine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorph... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Diamorphine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life... |
DB00804 | DB01619 | 1,507 | 830 | [
"DDInter543",
"DDInter1441"
] | Dicyclomine | Phenindamine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1507,
24,
830
]
],
[
[
1507,
24,
537
],
[
537,
40,
830
]
],
[
[
1507,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1507,
63,
357
],
[
357,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound... |
DB00569 | DB00686 | 553 | 383 | [
"DDInter775",
"DDInter1424"
] | Fondaparinux | Pentosan polysulfate | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Moderate | 1 | [
[
[
553,
24,
383
]
],
[
[
553,
21,
28898
],
[
28898,
60,
383
]
],
[
[
553,
25,
714
],
[
714,
63,
383
]
],
[
[
553,
64,
20
],
[
20,
2... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]
],
[
[
"Fondaparinux",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (... | Fondaparinux (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Pentosan polysulfate (Compound)
Fondaparinux may lead to a major life threatening interaction when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pentos... |
DB06674 | DB09054 | 908 | 384 | [
"DDInter837",
"DDInter905"
] | Golimumab | Idelalisib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
908,
25,
384
]
],
[
[
908,
25,
725
],
[
725,
63,
384
]
],
[
[
908,
64,
328
],
[
328,
24,
384
]
],
[
[
908,
63,
289
],
[
289,
24,... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
],
[
"Satralizumab",
"{u}... | Golimumab may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Golimumab may lead to a major life threatening interaction when taken with Mercaptopurine and Mercaptopurine may cause a mod... |
DB01501 | DB14575 | 1,118 | 733 | [
"DDInter549",
"DDInter674"
] | Difenoxin | Eslicarbazepine | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1118,
24,
733
]
],
[
[
1118,
63,
1614
],
[
1614,
24,
733
]
],
[
[
1118,
24,
1609
],
[
1609,
24,
733
]
],
[
[
1118,
1,
1688
],
[
1688,
... | [
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Difenoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pent... |
DB01069 | DB06282 | 401 | 516 | [
"DDInter1533",
"DDInter1053"
] | Promethazine | Levocetirizine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
401,
24,
516
]
],
[
[
401,
23,
771
],
[
771,
62,
516
]
],
[
[
401,
24,
1074
],
[
1074,
63,
516
]
],
[
[
401,
63,
701
],
[
701,
2... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],... | Promethazine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-12... |
DB00163 | DB01073 | 1,461 | 1,488 | [
"DDInter1943",
"DDInter745"
] | Vitamin E | Fludarabine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
1461,
24,
1488
]
],
[
[
1461,
24,
1426
],
[
1426,
1,
1488
]
],
[
[
1461,
24,
36
],
[
36,
63,
1488
]
],
[
[
1461,
24,
134
],
[
134,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Fludarabine (Compound)
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could ex... |
DB00470 | DB00903 | 530 | 1,680 | [
"DDInter601",
"DDInter686"
] | Dronabinol | Etacrynic acid | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Moderate | 1 | [
[
[
530,
24,
1680
]
],
[
[
530,
21,
29169
],
[
29169,
60,
1680
]
],
[
[
530,
24,
222
],
[
222,
63,
1680
]
],
[
[
530,
25,
593
],
[
593,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Dronabinol",
"{u} (Compound) causes {v} (Side Effect)",
"Tinnitus"
],
[
"Tinnitus",
"{u} (Side Effect) is ca... | Dronabinol (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Etacrynic acid (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Eta... |
DB00661 | DB11828 | 122 | 1,406 | [
"DDInter1928",
"DDInter1281"
] | Verapamil | Neratinib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
122,
25,
1406
]
],
[
[
122,
25,
1135
],
[
1135,
23,
1406
]
],
[
[
122,
24,
392
],
[
392,
24,
1406
]
],
[
[
122,
63,
1195
],
[
1195,
... | [
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ca... | Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderat... |
DB00218 | DB01592 | 1,176 | 1,596 | [
"DDInter1247",
"DDInter975"
] | Moxifloxacin | Iron | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1176,
24,
1596
]
],
[
[
1176,
21,
29243
],
[
29243,
60,
1596
]
],
[
[
1176,
24,
1193
],
[
1193,
62,
1596
]
],
[
[
1176,
24,
1096
],
[
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Wheezing"
],
[
"Wheezing",
"{u} (Side Effect) is caused b... | Moxifloxacin (Compound) causes Wheezing (Side Effect) and Wheezing (Side Effect) is caused by Iron (Compound)
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Iron
... |
DB00397 | DB11640 | 1,466 | 1,267 | [
"DDInter1458",
"DDInter64"
] | Phenylpropanolamine | Amifampridine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
1466,
24,
1267
]
],
[
[
1466,
63,
999
],
[
999,
24,
1267
]
],
[
[
1466,
24,
820
],
[
820,
24,
1267
]
],
[
[
1466,
25,
1039
],
[
1039,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thieth... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when... |
DB00814 | DB08890 | 1,171 | 16 | [
"DDInter1143",
"DDInter1069"
] | Meloxicam | Linaclotide | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin deri... | Minor | 0 | [
[
[
1171,
23,
16
]
],
[
[
1171,
63,
1314
],
[
1314,
40,
16
]
],
[
[
1171,
63,
1512
],
[
1512,
23,
16
]
],
[
[
1171,
24,
848
],
[
848,
... | [
[
[
"Meloxicam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Linaclotide (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a minor interaction that can l... |
DB00193 | DB00372 | 534 | 999 | [
"DDInter1841",
"DDInter1793"
] | Tramadol | Thiethylperazine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Major | 2 | [
[
[
534,
25,
999
]
],
[
[
534,
24,
286
],
[
286,
62,
999
]
],
[
[
534,
24,
1614
],
[
1614,
63,
999
]
],
[
[
534,
24,
352
],
[
352,
2... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
],
[
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Nab... |
DB00041 | DB00361 | 1,648 | 134 | [
"DDInter38",
"DDInter1939"
] | Aldesleukin | Vinorelbine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
1648,
24,
134
]
],
[
[
1648,
25,
147
],
[
147,
63,
134
]
],
[
[
1648,
23,
872
],
[
872,
62,
134
]
],
[
[
1648,
23,
1176
],
[
1176,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinblastine"
],
[
"Vinbla... | Aldesleukin may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may... |
DB00502 | DB00668 | 1,300 | 874 | [
"DDInter853",
"DDInter652"
] | Haloperidol | Epinephrine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1300,
24,
874
]
],
[
[
1300,
24,
688
],
[
688,
63,
874
]
],
[
[
1300,
25,
1674
],
[
1674,
63,
874
]
],
[
[
1300,
6,
7950
],
[
7950,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Haloperidol may lead to a major life threatening interaction when taken with Orciprenaline and Orciprenaline m... |
DB06603 | DB12364 | 39 | 1,421 | [
"DDInter1387",
"DDInter200"
] | Panobinostat | Betrixaban | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
39,
25,
1421
]
],
[
[
39,
63,
1091
],
[
1091,
24,
1421
]
],
[
[
39,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
39,
64,
529
],
[
529,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[
"Ampren... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lo... |
DB00398 | DB09122 | 79 | 1,613 | [
"DDInter1702",
"DDInter1409"
] | Sorafenib | Peginterferon beta-1a | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
79,
24,
1613
]
],
[
[
79,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
79,
63,
600
],
[
600,
24,
1613
]
],
[
[
79,
24,
1155
],
[
1155,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Fluconazol... |
DB00434 | DB01057 | 13 | 1,318 | [
"DDInter459",
"DDInter615"
] | Cyproheptadine | Echothiophate (ophthalmic) | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | Moderate | 1 | [
[
[
13,
24,
1318
]
],
[
[
13,
21,
28817
],
[
28817,
60,
1318
]
],
[
[
13,
24,
830
],
[
830,
63,
1318
]
],
[
[
13,
24,
1219
],
[
1219,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Echothiophate"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) causes {v} (Side Effect)",
"Vision blurred"
],
[
"Vision blurred",
"{u} ... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Echothiophate
Cyproheptadine (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Echothiophate (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases... |
DB00471 | DB11952 | 201 | 800 | [
"DDInter1242",
"DDInter612"
] | Montelukast | Duvelisib | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
201,
24,
800
]
],
[
[
201,
63,
254
],
[
254,
24,
800
]
],
[
[
201,
24,
522
],
[
522,
24,
800
]
],
[
[
201,
24,
1017
],
[
1017,
6... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitisinone"
],
[
... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafi... |
DB06448 | DB09082 | 171 | 659 | [
"DDInter1087",
"DDInter1934"
] | Lonafarnib | Vilanterol | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
171,
24,
659
]
],
[
[
171,
64,
1220
],
[
1220,
23,
659
]
],
[
[
171,
63,
891
],
[
891,
23,
659
]
],
[
[
171,
25,
927
],
[
927,
6... | [
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamet... | Lonafarnib may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone ma... |
DB00008 | DB08880 | 491 | 1,510 | [
"DDInter1407",
"DDInter1771"
] | Peginterferon alfa-2a | Teriflunomide | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
491,
25,
1510
]
],
[
[
491,
24,
505
],
[
505,
63,
1510
]
],
[
[
491,
24,
1136
],
[
1136,
24,
1510
]
],
[
[
491,
25,
1477
],
[
1477,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquin... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline and Diiodohydroxyquinoline may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Peginterferon alfa-2a may cause a moderate interaction that could exacerba... |
DB01045 | DB03404 | 463 | 765 | [
"DDInter1590",
"DDInter855"
] | Rifampicin | Hemin | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Major | 2 | [
[
[
463,
25,
765
]
],
[
[
463,
25,
840
],
[
840,
63,
765
]
],
[
[
463,
63,
1061
],
[
1061,
24,
765
]
],
[
[
463,
24,
477
],
[
477,
2... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hemin"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
],
[
"Vorapaxar",
"{u} may caus... | Rifampicin may lead to a major life threatening interaction when taken with Vorapaxar and Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Hemin
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a m... |
DB01309 | DB11943 | 1,254 | 255 | [
"DDInter933",
"DDInter495"
] | Insulin glulisine | Delafloxacin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Major | 2 | [
[
[
1254,
25,
255
]
],
[
[
1254,
63,
1479
],
[
1479,
24,
255
]
],
[
[
1254,
24,
52
],
[
52,
24,
255
]
],
[
[
1254,
24,
1385
],
[
1385,
... | [
[
[
"Insulin glulisine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delafloxacin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Insulin glulisine may cause a moderate interaction that could exacerbate diseases w... |
DB00477 | DB00539 | 216 | 11 | [
"DDInter363",
"DDInter1837"
] | Chlorpromazine | Toremifene | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
216,
25,
11
]
],
[
[
216,
63,
1594
],
[
1594,
40,
11
]
],
[
[
216,
24,
1376
],
[
1376,
40,
11
]
],
[
[
216,
6,
4973
],
[
4973,
4... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
"Do... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Toremifene (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Tore... |
DB00188 | DB09098 | 168 | 98 | [
"DDInter222",
"DDInter1700"
] | Bortezomib | Somatrem | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Minor | 0 | [
[
[
168,
23,
98
]
],
[
[
168,
24,
671
],
[
671,
24,
98
]
],
[
[
168,
23,
1671
],
[
1671,
24,
98
]
],
[
[
168,
25,
690
],
[
690,
24,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Somatrem"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Flibanserin and Flibans... |
DB00981 | DB01403 | 1,528 | 9 | [
"DDInter1462",
"DDInter1175"
] | Physostigmine | Methotrimeprazine | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1528,
24,
9
]
],
[
[
1528,
63,
1178
],
[
1178,
40,
9
]
],
[
[
1528,
63,
1164
],
[
1164,
1,
9
]
],
[
[
1528,
24,
401
],
[
401,
24... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazin... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resem... |
DB01583 | DB05351 | 624 | 101 | [
"DDInter1075",
"DDInter519"
] | Liotrix | Dexlansoprazole | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
624,
24,
101
]
],
[
[
624,
24,
16
],
[
16,
62,
101
]
],
[
[
624,
24,
428
],
[
428,
63,
101
]
],
[
[
624,
63,
1231
],
[
1231,
24,... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linaclotide"
],
[
... | Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and F... |
DB00945 | DB01240 | 1,479 | 885 | [
"DDInter20",
"DDInter657"
] | Acetylsalicylic acid | Epoprostenol | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1479,
24,
885
]
],
[
[
1479,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1479,
6,
6017
],
[
6017,
45,
885
]
],
[
[
1479,
21,
28936
],
[
28936,... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trepr... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Acetylsalicylic acid (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Acetylsalicylic acid (Compound) causes... |
DB00404 | DB09293 | 523 | 116 | [
"DDInter54",
"DDInter954"
] | Alprazolam | Iodide I-131 | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
523,
24,
116
]
],
[
[
523,
23,
1486
],
[
1486,
24,
116
]
],
[
[
523,
63,
701
],
[
701,
24,
116
]
],
[
[
523,
24,
516
],
[
516,
2... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methylprednisolone"
],
... | Alprazolam may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Clema... |
DB01118 | DB01611 | 33 | 1,487 | [
"DDInter76",
"DDInter893"
] | Amiodarone | Hydroxychloroquine | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
33,
25,
1487
]
],
[
[
33,
64,
1520
],
[
1520,
25,
1487
]
],
[
[
33,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
33,
21,
28658
],
[
28658,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Amiodarone may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Amiodarone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Amiodarone (Compound) causes Vom... |
DB00010 | DB00912 | 1,649 | 473 | [
"DDInter1661",
"DDInter1581"
] | Sermorelin | Repaglinide | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1649,
24,
473
]
],
[
[
1649,
24,
1645
],
[
1645,
24,
473
]
],
[
[
1649,
24,
433
],
[
433,
63,
473
]
],
[
[
1649,
24,
1645
],
[
1645,
... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
[
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin and Ertu... |
DB08820 | DB09034 | 1,478 | 1,313 | [
"DDInter997",
"DDInter1733"
] | Ivacaftor | Suvorexant | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
1478,
24,
1313
]
],
[
[
1478,
23,
1135
],
[
1135,
62,
1313
]
],
[
[
1478,
63,
1213
],
[
1213,
24,
1313
]
],
[
[
1478,
24,
1619
],
[
16... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Ivacaftor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"... | Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Suvorexant
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may c... |
DB00186 | DB00277 | 905 | 1,031 | [
"DDInter1092",
"DDInter1791"
] | Lorazepam | Theophylline | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Minor | 0 | [
[
[
905,
23,
1031
]
],
[
[
905,
23,
746
],
[
746,
40,
1031
]
],
[
[
905,
21,
29339
],
[
29339,
60,
1031
]
],
[
[
905,
40,
523
],
[
523,
... | [
[
[
"Lorazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
]
],
[
[
"Lorazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dyphylline"
],
[
... | Lorazepam may cause a minor interaction that can limit clinical effects when taken with Dyphylline and Dyphylline (Compound) resembles Theophylline (Compound)
Lorazepam (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Theophylline (Compound)
Lorazepam (Compoun... |
DB00317 | DB00615 | 883 | 690 | [
"DDInter810",
"DDInter1589"
] | Gefitinib | Rifabutin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
883,
24,
690
]
],
[
[
883,
24,
463
],
[
463,
1,
690
]
],
[
[
883,
6,
8374
],
[
8374,
45,
690
]
],
[
[
883,
18,
2183
],
[
2183,
5... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Gefitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Gefitinib (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is do... |
DB08816 | DB11652 | 578 | 1,155 | [
"DDInter1802",
"DDInter1891"
] | Ticagrelor | Tucatinib | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Major | 2 | [
[
[
578,
25,
1155
]
],
[
[
578,
63,
222
],
[
222,
23,
1155
]
],
[
[
578,
63,
1424
],
[
1424,
24,
1155
]
],
[
[
578,
64,
609
],
[
609,
... | [
[
[
"Ticagrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tucatinib"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramin... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine ma... |
DB09045 | DB14731 | 52 | 1,518 | [
"DDInter607",
"DDInter1741"
] | Dulaglutide | Tagraxofusp | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
52,
24,
1518
]
],
[
[
52,
62,
170
],
[
170,
24,
1518
]
],
[
[
52,
63,
176
],
[
176,
24,
1518
]
],
[
[
52,
24,
1296
],
[
1296,
24... | [
[
[
"Dulaglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Dulaglutide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sitagliptin"
],
[
... | Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Dulaglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine a... |
DB09122 | DB12001 | 1,613 | 564 | [
"DDInter1409",
"DDInter7"
] | Peginterferon beta-1a | Abemaciclib | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
1613,
24,
564
]
],
[
[
1613,
63,
868
],
[
868,
24,
564
]
],
[
[
1613,
24,
242
],
[
242,
63,
564
]
],
[
[
1613,
64,
139
],
[
139,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemu... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00470 | DB01142 | 530 | 1,264 | [
"DDInter601",
"DDInter593"
] | Dronabinol | Doxepin | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
530,
24,
1264
]
],
[
[
530,
63,
508
],
[
508,
24,
1264
]
],
[
[
530,
24,
401
],
[
401,
24,
1264
]
],
[
[
530,
24,
649
],
[
649,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethaz... |
DB01610 | DB04865 | 248 | 4 | [
"DDInter1912",
"DDInter1335"
] | Valganciclovir | Omacetaxine mepesuccinate | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
248,
24,
4
]
],
[
[
248,
63,
1394
],
[
1394,
24,
4
]
],
[
[
248,
24,
745
],
[
745,
63,
4
]
],
[
[
248,
40,
563
],
[
563,
24,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritu... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Rituximab and Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00863 | DB09143 | 1,194 | 313 | [
"DDInter1568",
"DDInter1701"
] | Ranitidine | Sonidegib | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Minor | 0 | [
[
[
1194,
23,
313
]
],
[
[
1194,
40,
1127
],
[
1127,
23,
313
]
],
[
[
1194,
24,
478
],
[
478,
24,
313
]
],
[
[
1194,
25,
1213
],
[
1213,
... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sonidegib"
]
],
[
[
"Ranitidine",
"{u} (Compound) resembles {v} (Compound)",
"Nizatidine"
],
[
"Nizatidine",
"{u} may cause a minor inte... | Ranitidine (Compound) resembles Nizatidine (Compound) and Nizatidine may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exac... |
DB00033 | DB08880 | 342 | 1,510 | [
"DDInter949",
"DDInter1771"
] | Interferon gamma-1b | Teriflunomide | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
342,
25,
1510
]
],
[
[
342,
24,
1031
],
[
1031,
24,
1510
]
],
[
[
342,
25,
593
],
[
593,
25,
1510
]
],
[
[
342,
24,
713
],
[
713,
... | [
[
[
"Interferon gamma-1b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Interferon gamma-1b may lead to a major life threatening interaction when taken with Bupropion a... |
DB00218 | DB00938 | 1,176 | 455 | [
"DDInter1247",
"DDInter1635"
] | Moxifloxacin | Salmeterol | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1176,
24,
455
]
],
[
[
1176,
24,
688
],
[
688,
63,
455
]
],
[
[
1176,
6,
3199
],
[
3199,
57,
455
]
],
[
[
1176,
21,
29095
],
[
29095,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Salmeterol (Compound)
Moxiflox... |
DB00031 | DB08901 | 20 | 1,468 | [
"DDInter1764",
"DDInter1492"
] | Tenecteplase | Ponatinib | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
20,
25,
1468
]
],
[
[
20,
24,
1230
],
[
1230,
24,
1468
]
],
[
[
20,
24,
41
],
[
41,
63,
1468
]
],
[
[
20,
25,
4
],
[
4,
24,
... | [
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
"Citalop... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran an... |
DB08899 | DB12500 | 129 | 283 | [
"DDInter649",
"DDInter714"
] | Enzalutamide | Fedratinib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
129,
25,
283
]
],
[
[
129,
62,
271
],
[
271,
23,
283
]
],
[
[
129,
25,
907
],
[
907,
23,
283
]
],
[
[
129,
25,
466
],
[
466,
62,... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Enzalutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegr... | Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Enzalutamide may lead to a major life threatening interaction when taken with Doravirine and Doravirine may cause ... |
DB00281 | DB01381 | 608 | 958 | [
"DDInter1066",
"DDInter819"
] | Lidocaine | Ginkgo biloba | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
608,
24,
958
]
],
[
[
608,
24,
1010
],
[
1010,
24,
958
]
],
[
[
608,
23,
129
],
[
129,
63,
958
]
],
[
[
608,
25,
593
],
[
593,
2... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Lidocaine may cause a minor interaction that can limit clinical effects when taken with Enzalutamide and Enzal... |
DB01110 | DB09143 | 86 | 313 | [
"DDInter1209",
"DDInter1701"
] | Miconazole | Sonidegib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Moderate | 1 | [
[
[
86,
24,
313
]
],
[
[
86,
24,
478
],
[
478,
24,
313
]
],
[
[
86,
24,
484
],
[
484,
63,
313
]
],
[
[
86,
63,
1028
],
[
1028,
24,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sonidegib"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sonidegib
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrecti... |
DB00530 | DB00607 | 1,195 | 1,249 | [
"DDInter667",
"DDInter1256"
] | Erlotinib | Nafcillin | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Moderate | 1 | [
[
[
1195,
24,
1249
]
],
[
[
1195,
6,
7950
],
[
7950,
45,
1249
]
],
[
[
1195,
18,
4360
],
[
4360,
57,
1249
]
],
[
[
1195,
21,
28792
],
[
28... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Erlotinib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nafcillin (Compound)
Erlotinib (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Nafcillin (Compound)
Erlotinib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused ... |
DB00222 | DB00679 | 245 | 684 | [
"DDInter825",
"DDInter1796"
] | Glimepiride | Thioridazine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
245,
24,
684
]
],
[
[
245,
24,
1237
],
[
1237,
40,
684
]
],
[
[
245,
24,
216
],
[
216,
1,
684
]
],
[
[
245,
6,
6017
],
[
6017,
4... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thiori... |
DB00570 | DB16627 | 147 | 1,125 | [
"DDInter1936",
"DDInter1145"
] | Vinblastine | Melphalan flufenamide | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. _In vitro_ models show that melphalan is 10 to hundreds of times more potent than melphala... | Moderate | 1 | [
[
[
147,
24,
1125
]
],
[
[
147,
24,
611
],
[
611,
24,
1125
]
],
[
[
147,
24,
611
],
[
611,
24,
1224
],
[
1224,
24,
1125
]
],
[
[
147,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan flufenamide"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine and Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan flufenamide
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Dacarb... |
DB01041 | DB10316 | 770 | 334 | [
"DDInter1789",
"DDInter1248"
] | Thalidomide | Mumps virus strain B level jeryl lynn live antigen | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
770,
25,
334
]
],
[
[
770,
64,
1057
],
[
1057,
25,
334
]
],
[
[
770,
25,
1316
],
[
1316,
64,
334
]
],
[
[
770,
25,
908
],
[
908,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Thalidomide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Thalidomide may lead to a major life threatening interaction when taken with Durvalumab and Durvaluma... |
DB06589 | DB08899 | 1,250 | 129 | [
"DDInter1400",
"DDInter649"
] | Pazopanib | Enzalutamide | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1250,
24,
129
]
],
[
[
1250,
63,
918
],
[
918,
1,
129
]
],
[
[
1250,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1250,
7,
5774
],
[
5774,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Pazopanib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Pazopanib (Compound) upregulates SELL (Gene) and SELL (Gene)... |
DB00202 | DB00618 | 190 | 1,572 | [
"DDInter1716",
"DDInter498"
] | Succinylcholine | Demeclocycline | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Moderate | 1 | [
[
[
190,
24,
1572
]
],
[
[
190,
24,
1620
],
[
1620,
1,
1572
]
],
[
[
190,
24,
1669
],
[
1669,
40,
1572
]
],
[
[
190,
24,
1031
],
[
1031,
... | [
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
]
],
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"... | Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Demeclocycline (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and Minocycline (Compound) resembles De... |
DB00367 | DB11767 | 566 | 1,583 | [
"DDInter1061",
"DDInter1643"
] | Levonorgestrel | Sarilumab | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
566,
24,
1583
]
],
[
[
566,
40,
890
],
[
890,
24,
1583
]
],
[
[
566,
1,
1336
],
[
1336,
24,
1583
]
],
[
[
566,
24,
1362
],
[
1362,
... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) resembles {v} (Compound)",
"Mestranol"
],
[
"Mestranol",
"{u} may cause a mo... | Levonorgestrel (Compound) resembles Mestranol (Compound) and Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Levonorgestrel (Compound) resembles Etonogestrel (Compound) and Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Sa... |
DB00334 | DB01309 | 867 | 1,254 | [
"DDInter1326",
"DDInter933"
] | Olanzapine | Insulin glulisine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
867,
24,
1254
]
],
[
[
867,
25,
1621
],
[
1621,
23,
1254
]
],
[
[
867,
24,
274
],
[
274,
23,
1254
]
],
[
[
867,
24,
1424
],
[
1424,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Olanzapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
],
[
... | Olanzapine may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine an... |
DB00675 | DB01320 | 888 | 651 | [
"DDInter1744",
"DDInter783"
] | Tamoxifen | Fosphenytoin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
888,
24,
651
]
],
[
[
888,
24,
307
],
[
307,
1,
651
]
],
[
[
888,
40,
11234
],
[
11234,
40,
651
]
],
[
[
888,
63,
362
],
[
362,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Tamoxifen (Compound) resembles Benzyl Benzoate (Compound) and Benzyl Benzoate (Compound) resembles Fosphenytoin (Compound)
Tamoxifen may cause a moderate interac... |
DB00008 | DB09208 | 491 | 934 | [
"DDInter1407",
"DDInter1410"
] | Peginterferon alfa-2a | Pegloticase | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin. In gout patients treated with pegloticase, the conve... | Moderate | 1 | [
[
[
491,
24,
934
]
],
[
[
491,
24,
1257
],
[
1257,
24,
934
]
],
[
[
491,
24,
919
],
[
919,
63,
934
]
],
[
[
491,
24,
1257
],
[
1257,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegloticase"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegf... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim and Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Pegloticase
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when tak... |
DB00902 | DB01200 | 104 | 469 | [
"DDInter1168",
"DDInter243"
] | Methdilazine | Bromocriptine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
104,
24,
469
]
],
[
[
104,
24,
401
],
[
401,
24,
469
]
],
[
[
104,
63,
701
],
[
701,
24,
469
]
],
[
[
104,
24,
407
],
[
407,
63,... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Bromocriptine
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine... |
DB00726 | DB11730 | 1,164 | 351 | [
"DDInter1876",
"DDInter1588"
] | Trimipramine | Ribociclib | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1164,
25,
351
]
],
[
[
1164,
23,
112
],
[
112,
23,
351
]
],
[
[
1164,
25,
222
],
[
222,
23,
351
]
],
[
[
1164,
24,
283
],
[
283,
... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Trimipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Trimipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Trimipramine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine ma... |
DB00563 | DB11767 | 663 | 1,583 | [
"DDInter1174",
"DDInter1643"
] | Methotrexate | Sarilumab | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
663,
24,
1583
]
],
[
[
663,
63,
1461
],
[
1461,
23,
1583
]
],
[
[
663,
24,
267
],
[
267,
24,
1583
]
],
[
[
663,
63,
362
],
[
362,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrex... |
DB06212 | DB08820 | 165 | 1,478 | [
"DDInter1833",
"DDInter997"
] | Tolvaptan | Ivacaftor | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
165,
24,
1478
]
],
[
[
165,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
165,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
165,
23,
1135
],
[
1135,... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Tolvaptan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tolvaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Tolvaptan (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Tolvaptan may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may ... |
DB00081 | DB10897 | 273 | 539 | [
"DDInter1838",
"DDInter291"
] | Tositumomab | Capsicum | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
273,
23,
539
]
],
[
[
273,
25,
885
],
[
885,
23,
539
]
],
[
[
273,
64,
582
],
[
582,
23,
539
]
],
[
[
273,
24,
578
],
[
578,
23,... | [
[
[
"Tositumomab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
],
[
"Epoprosten... | Tositumomab may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Tositumomab may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a minor interac... |
DB06700 | DB11130 | 643 | 407 | [
"DDInter511",
"DDInter1344"
] | Desvenlafaxine | Opium | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
643,
24,
407
]
],
[
[
643,
63,
662
],
[
662,
24,
407
]
],
[
[
643,
64,
1264
],
[
1264,
24,
407
]
],
[
[
643,
40,
1100
],
[
1100,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Desvenlafaxine may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cau... |
DB01001 | DB11730 | 688 | 351 | [
"DDInter1632",
"DDInter1588"
] | Salbutamol | Ribociclib | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
688,
25,
351
]
],
[
[
688,
23,
1247
],
[
1247,
23,
351
]
],
[
[
688,
62,
112
],
[
112,
23,
351
]
],
[
[
688,
24,
222
],
[
222,
2... | [
[
[
"Salbutamol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB00252 | DB00863 | 362 | 1,194 | [
"DDInter1460",
"DDInter1568"
] | Phenytoin | Ranitidine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Moderate | 1 | [
[
[
362,
24,
1194
]
],
[
[
362,
6,
8374
],
[
8374,
45,
1194
]
],
[
[
362,
21,
29090
],
[
29090,
60,
1194
]
],
[
[
362,
24,
1468
],
[
1468,... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenytoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Phenytoin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Ranitidine (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ponatini... |
DB00047 | DB01211 | 176 | 609 | [
"DDInter932",
"DDInter393"
] | Insulin glargine | Clarithromycin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
176,
24,
609
]
],
[
[
176,
24,
1101
],
[
1101,
23,
609
]
],
[
[
176,
24,
34
],
[
34,
62,
609
]
],
[
[
176,
24,
52
],
[
52,
63,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Fosampr... |
DB06674 | DB11730 | 908 | 351 | [
"DDInter837",
"DDInter1588"
] | Golimumab | Ribociclib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
908,
25,
351
]
],
[
[
908,
63,
112
],
[
112,
23,
351
]
],
[
[
908,
25,
310
],
[
310,
24,
351
]
],
[
[
908,
63,
597
],
[
597,
24,... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Golimumab may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may ca... |
DB01362 | DB04861 | 497 | 1,592 | [
"DDInter960",
"DDInter1271"
] | Iohexol | Nebivolol | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
497,
24,
1592
]
],
[
[
497,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
497,
64,
1528
],
[
1528,
24,
1592
]
],
[
[
497,
24,
512
],
[
512,
... | [
[
[
"Iohexol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Iohexol",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v}... | Iohexol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Iohexol may lead to a major life threatening interaction when taken with Physostigmine and Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol
Iohexol may cau... |
DB00515 | DB00526 | 589 | 1,555 | [
"DDInter387",
"DDInter1355"
] | Cisplatin | Oxaliplatin | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
589,
24,
1555
]
],
[
[
589,
6,
2484
],
[
2484,
45,
1555
]
],
[
[
589,
54,
19299
],
[
19299,
15,
1555
]
],
[
[
589,
63,
141
],
[
141,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Cisplatin",
"{u} (Compound) binds {v} (Gene)",
"ATP7B"
],
[
"ATP7B",
"{u} (Gene) is bound by {v} (Compound)",
... | Cisplatin (Compound) binds ATP7B (Gene) and ATP7B (Gene) is bound by Oxaliplatin (Compound)
Cisplatin (Compound) is included by Platinum-containing Compounds (Pharmacologic Class) and Platinum-containing Compounds (Pharmacologic Class) includes Oxaliplatin (Compound)
Cisplatin may cause a moderate interaction that coul... |
DB00295 | DB01563 | 475 | 680 | [
"DDInter1244",
"DDInter349"
] | Morphine | Chloral hydrate | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. | Major | 2 | [
[
[
475,
25,
680
]
],
[
[
475,
24,
272
],
[
272,
24,
680
]
],
[
[
475,
25,
593
],
[
593,
24,
680
]
],
[
[
475,
24,
1609
],
[
1609,
6... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chloral hydrate"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
],
[
"Chl... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Morphine may lead to a major life threatening interaction when taken with Bupropion and Bupropion... |
DB00366 | DB00413 | 1,594 | 1,346 | [
"DDInter600",
"DDInter1505"
] | Doxylamine | Pramipexole | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) . It was first approved by the FDA in 1997 . Parkinson's Disease is one of the m... | Moderate | 1 | [
[
[
1594,
24,
1346
]
],
[
[
1594,
21,
28784
],
[
28784,
60,
1346
]
],
[
[
1594,
24,
832
],
[
832,
63,
1346
]
],
[
[
1594,
35,
272
],
[
272... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramipexole"
]
],
[
[
"Doxylamine",
"{u} (Compound) causes {v} (Side Effect)",
"Thrombocytopenia"
],
[
"Thrombocytopenia",
"{u} (Side ... | Doxylamine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Pramipexole (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases ... |
DB00861 | DB06779 | 914 | 365 | [
"DDInter551",
"DDInter470"
] | Diflunisal | Dalteparin | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
914,
25,
365
]
],
[
[
914,
63,
305
],
[
305,
24,
365
]
],
[
[
914,
24,
116
],
[
116,
63,
365
]
],
[
[
914,
24,
1039
],
[
1039,
2... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
],
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Diflunisal may cause a moderate interaction that could exacerbate diseases... |
DB00468 | DB01064 | 1,424 | 1,148 | [
"DDInter1557",
"DDInter987"
] | Quinine | Isoprenaline | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1424,
24,
1148
]
],
[
[
1424,
24,
480
],
[
480,
24,
1148
]
],
[
[
1424,
6,
9842
],
[
9842,
45,
1148
]
],
[
[
1424,
21,
28717
],
[
2871... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Quinine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Isoprenaline (Compound)
Quinine (Compound) c... |
DB00771 | DB01591 | 262 | 667 | [
"DDInter397",
"DDInter1696"
] | Clidinium | Solifenacin | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
262,
24,
667
]
],
[
[
262,
6,
7992
],
[
7992,
45,
667
]
],
[
[
262,
24,
830
],
[
830,
63,
667
]
],
[
[
262,
24,
104
],
[
104,
24... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Clidinium",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Clidinium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Solifenacin (Compound)
Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Solifenacin
Clidinium may ca... |
DB00804 | DB00810 | 1,507 | 456 | [
"DDInter543",
"DDInter211"
] | Dicyclomine | Biperiden | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Moderate | 1 | [
[
[
1507,
24,
456
]
],
[
[
1507,
63,
1105
],
[
1105,
40,
456
]
],
[
[
1507,
6,
4304
],
[
4304,
45,
456
]
],
[
[
1507,
24,
104
],
[
104,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Dicyclomine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Biperiden (Compound)
Dicyclomine may cause a moderate interaction that could ex... |
DB00744 | DB09054 | 1,288 | 384 | [
"DDInter1962",
"DDInter905"
] | Zileuton | Idelalisib | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1288,
24,
384
]
],
[
[
1288,
63,
305
],
[
305,
24,
384
]
],
[
[
1288,
24,
868
],
[
868,
24,
384
]
],
[
[
1288,
24,
1619
],
[
1619,
... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
... | Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Zileuton may cause a moderate interaction that could exacerbate diseases whe... |
DB00363 | DB01097 | 695 | 1,377 | [
"DDInter419",
"DDInter1033"
] | Clozapine | Leflunomide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
695,
25,
1377
]
],
[
[
695,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
695,
24,
126
],
[
126,
24,
1377
]
],
[
[
695,
24,
1411
],
[
1411,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Leflunom... | Clozapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Clozapine may cause a ... |
DB01309 | DB01367 | 1,254 | 1,163 | [
"DDInter933",
"DDInter1572"
] | Insulin glulisine | Rasagiline | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1254,
24,
1163
]
],
[
[
1254,
63,
590
],
[
590,
24,
1163
]
],
[
[
1254,
24,
22
],
[
22,
24,
1163
]
],
[
[
1254,
62,
274
],
[
274,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with E... |
DB00450 | DB11837 | 78 | 1,297 | [
"DDInter603",
"DDInter1351"
] | Droperidol | Osilodrostat | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
78,
25,
1297
]
],
[
[
78,
23,
112
],
[
112,
23,
1297
]
],
[
[
78,
24,
222
],
[
222,
23,
1297
]
],
[
[
78,
25,
401
],
[
401,
24,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and S... |
DB00682 | DB04855 | 126 | 540 | [
"DDInter1951",
"DDInter602"
] | Warfarin | Dronedarone | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
126,
24,
540
]
],
[
[
126,
25,
33
],
[
33,
40,
540
]
],
[
[
126,
6,
8374
],
[
8374,
45,
540
]
],
[
[
126,
25,
112
],
[
112,
23,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiodarone",
... | Warfarin may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Warfarin may lead to a major life threatening interaction when taken with Metronida... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.