drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00242 | DB01157 | 1,064 | 304 | [
"DDInter392",
"DDInter1875"
] | Cladribine | Trimetrexate | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Major | 2 | [
[
[
1064,
25,
304
]
],
[
[
1064,
21,
28703
],
[
28703,
60,
304
]
],
[
[
1064,
64,
58
],
[
58,
24,
304
]
],
[
[
1064,
24,
1270
],
[
1270,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimetrexate"
]
],
[
[
"Cladribine",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused by {v} (Comp... | Cladribine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Trimetrexate (Compound)
Cladribine may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Cladribine ... |
DB00563 | DB01032 | 663 | 824 | [
"DDInter1174",
"DDInter1522"
] | Methotrexate | Probenecid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. | Major | 2 | [
[
[
663,
25,
824
]
],
[
[
663,
6,
5912
],
[
5912,
45,
824
]
],
[
[
663,
21,
28722
],
[
28722,
60,
824
]
],
[
[
663,
25,
1274
],
[
1274,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Probenecid"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",
"Probe... | Methotrexate (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Probenecid (Compound)
Methotrexate (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Probenecid (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may ca... |
DB00445 | DB00857 | 322 | 1,387 | [
"DDInter655",
"DDInter1768"
] | Epirubicin | Terbinafine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
322,
24,
1387
]
],
[
[
322,
7,
6808
],
[
6808,
46,
1387
]
],
[
[
322,
18,
9971
],
[
9971,
46,
1387
]
],
[
[
322,
18,
4360
],
[
4360,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Epirubicin",
"{u} (Compound) upregulates {v} (Gene)",
"LGMN"
],
[
"LGMN",
"{u} (Gene) is upregulated by {v} (Co... | Epirubicin (Compound) upregulates LGMN (Gene) and LGMN (Gene) is upregulated by Terbinafine (Compound)
Epirubicin (Compound) downregulates UAP1 (Gene) and UAP1 (Gene) is upregulated by Terbinafine (Compound)
Epirubicin (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Terbinafine (Compound)
Epi... |
DB01227 | DB09080 | 1,301 | 144 | [
"DDInter1043",
"DDInter1331"
] | Levacetylmethadol | Olodaterol | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1301,
24,
144
]
],
[
[
1301,
25,
1011
],
[
1011,
24,
144
]
],
[
[
1301,
64,
11
],
[
11,
24,
144
]
],
[
[
1301,
74,
543
],
[
543,
... | [
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
... | Levacetylmethadol may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Levacetylmethadol may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a... |
DB00738 | DB09082 | 485 | 659 | [
"DDInter1420",
"DDInter1934"
] | Pentamidine | Vilanterol | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
485,
24,
659
]
],
[
[
485,
63,
1570
],
[
1570,
24,
659
]
],
[
[
485,
24,
1296
],
[
1296,
63,
659
]
],
[
[
485,
25,
1069
],
[
1069,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Insulin deglude... |
DB00175 | DB00445 | 681 | 322 | [
"DDInter1509",
"DDInter655"
] | Pravastatin | Epirubicin | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
681,
24,
322
]
],
[
[
681,
21,
28963
],
[
28963,
60,
322
]
],
[
[
681,
24,
112
],
[
112,
62,
322
]
],
[
[
681,
24,
134
],
[
134,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Pravastatin",
"{u} (Compound) causes {v} (Side Effect)",
"Anxiety"
],
[
"Anxiety",
"{u} (Side Effect) is caused... | Pravastatin (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Epirubicin (Compound)
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Epiru... |
DB00595 | DB05528 | 1,545 | 1,070 | [
"DDInter1374",
"DDInter1228"
] | Oxytetracycline | Mipomersen | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1545,
25,
1070
]
],
[
[
1545,
25,
1517
],
[
1517,
25,
1070
]
],
[
[
1545,
24,
384
],
[
384,
64,
1070
]
],
[
[
1545,
40,
1620
],
[
1620... | [
[
[
"Oxytetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Oxytetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isotretinoin"
],
[
"Isotretinoin"... | Oxytetracycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Mipomersen
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may lead to... |
DB00938 | DB01211 | 455 | 609 | [
"DDInter1635",
"DDInter393"
] | Salmeterol | Clarithromycin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
455,
25,
609
]
],
[
[
455,
63,
1570
],
[
1570,
24,
609
]
],
[
[
455,
6,
7524
],
[
7524,
45,
609
]
],
[
[
455,
18,
2183
],
[
2183,
... | [
[
[
"Salmeterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
"Azit... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Salmeterol (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Salmet... |
DB00242 | DB11627 | 1,064 | 1,367 | [
"DDInter392",
"DDInter860"
] | Cladribine | Hepatitis B Vaccine (Recombinant) | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1064,
24,
1367
]
],
[
[
1064,
36,
1083
],
[
1083,
24,
1367
]
],
[
[
1064,
64,
1648
],
[
1648,
24,
1367
]
],
[
[
1064,
25,
1480
],
[
14... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Cladribine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when... | Cladribine (Compound) resembles Trifluridine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Cladribine may lead to a major life thre... |
DB01211 | DB08864 | 609 | 786 | [
"DDInter393",
"DDInter1595"
] | Clarithromycin | Rilpivirine | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
609,
24,
786
]
],
[
[
609,
24,
655
],
[
655,
1,
786
]
],
[
[
609,
6,
8374
],
[
8374,
45,
786
]
],
[
[
609,
21,
29343
],
[
29343,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Clarithromycin (Compound) causes Blood creatinine increa... |
DB00978 | DB01169 | 739 | 57 | [
"DDInter1084",
"DDInter120"
] | Lomefloxacin | Arsenic trioxide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
739,
25,
57
]
],
[
[
739,
6,
5912
],
[
5912,
45,
57
]
],
[
[
739,
62,
112
],
[
112,
23,
57
]
],
[
[
739,
24,
603
],
[
603,
63,
... | [
[
[
"Lomefloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",
... | Lomefloxacin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Arsenic trioxide (Compound)
Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Lo... |
DB00059 | DB00359 | 1,560 | 161 | [
"DDInter1404",
"DDInter1721"
] | Pegaspargase | Sulfadiazine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Moderate | 1 | [
[
[
1560,
24,
161
]
],
[
[
1560,
24,
1029
],
[
1029,
40,
161
]
],
[
[
1560,
63,
1179
],
[
1179,
24,
161
]
],
[
[
1560,
24,
959
],
[
959,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxazole"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfadiazine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro may cause a moderate in... |
DB00252 | DB06410 | 362 | 1,196 | [
"DDInter1460",
"DDInter595"
] | Phenytoin | Doxercalciferol | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney d... | Moderate | 1 | [
[
[
362,
24,
1196
]
],
[
[
362,
24,
286
],
[
286,
63,
1196
]
],
[
[
362,
25,
1017
],
[
1017,
63,
1196
]
],
[
[
362,
1,
759
],
[
759,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxercalciferol"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Doxercalciferol
Phenytoin may lead to a major life threatening interaction when taken with Lorlatinib and ... |
DB00637 | DB01263 | 1,557 | 859 | [
"DDInter128",
"DDInter1494"
] | Astemizole | Posaconazole | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Major | 2 | [
[
[
1557,
25,
859
]
],
[
[
1557,
6,
4973
],
[
4973,
45,
859
]
],
[
[
1557,
23,
112
],
[
112,
23,
859
]
],
[
[
1557,
63,
1101
],
[
1101,
... | [
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Posaconazole"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Posacon... | Astemizole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Posaconazole
Astemizole may... |
DB00352 | DB14761 | 482 | 242 | [
"DDInter1814",
"DDInter1578"
] | Tioguanine | Remdesivir | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
482,
24,
242
]
],
[
[
482,
24,
1130
],
[
1130,
24,
242
]
],
[
[
482,
25,
1377
],
[
1377,
24,
242
]
],
[
[
482,
63,
367
],
[
367,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Tioguanine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may ... |
DB01023 | DB08899 | 409 | 129 | [
"DDInter716",
"DDInter649"
] | Felodipine | Enzalutamide | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
409,
25,
129
]
],
[
[
409,
6,
8374
],
[
8374,
45,
129
]
],
[
[
409,
21,
28703
],
[
28703,
60,
129
]
],
[
[
409,
63,
1512
],
[
1512,
... | [
[
[
"Felodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Felodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Enzal... | Felodipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Felodipine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Di... |
DB00836 | DB01177 | 543 | 77 | [
"DDInter1088",
"DDInter904"
] | Loperamide | Idarubicin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
543,
24,
77
]
],
[
[
543,
6,
12523
],
[
12523,
45,
77
]
],
[
[
543,
7,
6952
],
[
6952,
46,
77
]
],
[
[
543,
18,
1853
],
[
1853,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Loperamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Loperamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Loperamide (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound)
Loperamide (Compound) downregulates CRK (Gene) and CRK (Gene) is downregulated by Idarubicin (Compound)
Loperamide (Comp... |
DB00047 | DB01044 | 176 | 246 | [
"DDInter932",
"DDInter809"
] | Insulin glargine | Gatifloxacin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
176,
25,
246
]
],
[
[
176,
25,
739
],
[
739,
1,
246
]
],
[
[
176,
25,
945
],
[
945,
40,
246
]
],
[
[
176,
24,
1479
],
[
1479,
24... | [
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxa... | Insulin glargine may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Insulin glargine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gatifloxacin (Compound)
Insuli... |
DB00284 | DB00951 | 1,647 | 1,072 | [
"DDInter11",
"DDInter986"
] | Acarbose | Isoniazid | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1647,
24,
1072
]
],
[
[
1647,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
1647,
24,
1486
],
[
1486,
62,
1072
]
],
[
[
1647,
24,
870
],
[
8... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Acarbose",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (... | Acarbose (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Ison... |
DB01001 | DB01100 | 688 | 1,568 | [
"DDInter1632",
"DDInter1470"
] | Salbutamol | Pimozide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
688,
24,
1568
]
],
[
[
688,
63,
78
],
[
78,
40,
1568
]
],
[
[
688,
63,
1557
],
[
1557,
25,
1568
]
],
[
[
688,
6,
8374
],
[
8374,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may lead to a major life threatening interact... |
DB00976 | DB11921 | 1,056 | 1,019 | [
"DDInter1758",
"DDInter492"
] | Telithromycin | Deflazacort | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1056,
25,
1019
]
],
[
[
1056,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
1056,
24,
761
],
[
761,
24,
1019
]
],
[
[
1056,
64,
629
],
[
629,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
"Ruca... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and ... |
DB00738 | DB00978 | 485 | 739 | [
"DDInter1420",
"DDInter1084"
] | Pentamidine | Lomefloxacin | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
485,
24,
739
]
],
[
[
485,
25,
945
],
[
945,
40,
739
]
],
[
[
485,
24,
872
],
[
872,
40,
739
]
],
[
[
485,
64,
1176
],
[
1176,
1... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Spar... | Pentamidine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Lomefloxacin (Compound)
P... |
DB01050 | DB01324 | 848 | 178 | [
"DDInter900",
"DDInter1490"
] | Ibuprofen | Polythiazide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
848,
24,
178
]
],
[
[
848,
63,
674
],
[
674,
40,
178
]
],
[
[
848,
21,
28835
],
[
28835,
60,
178
]
],
[
[
848,
64,
126
],
[
126,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
],
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Ibuprofen (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Ibuprofen may le... |
DB05528 | DB09079 | 1,070 | 1,496 | [
"DDInter1228",
"DDInter1296"
] | Mipomersen | Nintedanib | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Major | 2 | [
[
[
1070,
25,
1496
]
],
[
[
1070,
64,
609
],
[
609,
24,
1496
]
],
[
[
1070,
25,
1593
],
[
1593,
24,
1496
]
],
[
[
1070,
25,
159
],
[
159,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nintedanib"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromycin",
... | Mipomersen may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Mipomersen may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moder... |
DB00907 | DB00988 | 290 | 817 | [
"DDInter427",
"DDInter584"
] | Cocaine (topical) | Dopamine | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Major | 2 | [
[
[
290,
25,
817
]
],
[
[
290,
64,
532
],
[
532,
1,
817
]
],
[
[
290,
25,
584
],
[
584,
1,
817
]
],
[
[
290,
25,
1148
],
[
1148,
63,... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dopamine"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dobutamine"
],
[
"Dobutamine",
"{u} (Compound... | Cocaine may lead to a major life threatening interaction when taken with Dopamine
Cocaine may lead to a major life threatening interaction when taken with Dobutamine and Dobutamine (Compound) resembles Dopamine (Compound)
Cocaine may lead to a major life threatening interaction when taken with Levonordefrin and Levonor... |
DB08820 | DB08912 | 1,478 | 1,040 | [
"DDInter997",
"DDInter462"
] | Ivacaftor | Dabrafenib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1478,
24,
1040
]
],
[
[
1478,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1478,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
1478,
23,
271
],
[
27... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Ivacaftor",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ivacaftor (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Ivacaftor (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Mirabegron and M... |
DB00976 | DB12500 | 1,056 | 283 | [
"DDInter1758",
"DDInter714"
] | Telithromycin | Fedratinib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1056,
25,
283
]
],
[
[
1056,
24,
466
],
[
466,
62,
283
]
],
[
[
1056,
25,
351
],
[
351,
23,
283
]
],
[
[
1056,
63,
1419
],
[
1419,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Da... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Telithromycin may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib ma... |
DB00519 | DB06723 | 1,638 | 115 | [
"DDInter1843",
"DDInter58"
] | Trandolapril | Aluminum hydroxide | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
1638,
23,
115
]
],
[
[
1638,
21,
28643
],
[
28643,
60,
115
]
],
[
[
1638,
1,
1058
],
[
1058,
23,
115
]
],
[
[
1638,
24,
870
],
[
870,
... | [
[
[
"Trandolapril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Trandolapril",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effec... | Trandolapril (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Trandolapril (Compound) resembles Moexipril (Compound) and Moexipril may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Trandolapril may cause a mod... |
DB00295 | DB00780 | 475 | 551 | [
"DDInter1244",
"DDInter1440"
] | Morphine | Phenelzine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Major | 2 | [
[
[
475,
25,
551
]
],
[
[
475,
24,
94
],
[
94,
40,
551
]
],
[
[
475,
6,
3486
],
[
3486,
45,
551
]
],
[
[
475,
21,
28827
],
[
28827,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
],
[
"Phenacemide",... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Phenelzine (Compound)
Morphine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Phenelzine (Compound)
Morphine (Compound) causes Orthostatic hypotension (Side Effect) and... |
DB00169 | DB00375 | 386 | 1,037 | [
"DDInter367",
"DDInter433"
] | Cholecalciferol | Colestipol | Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-... | Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally o... | Moderate | 1 | [
[
[
386,
24,
1037
]
],
[
[
386,
75,
160
],
[
160,
24,
1037
]
],
[
[
386,
25,
1098
],
[
1098,
63,
1037
]
],
[
[
386,
75,
160
],
[
160,
... | [
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colestipol"
]
],
[
[
"Cholecalciferol",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {... | Cholecalciferol (Compound) resembles Calcifediol (Compound) and Cholecalciferol may lead to a major life threatening interaction when taken with Calcifediol and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Colestipol
Cholecalciferol may lead to a major life threatening int... |
DB11113 | DB11837 | 657 | 1,297 | [
"DDInter307",
"DDInter1351"
] | Castor oil | Osilodrostat | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of, which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic,... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
657,
24,
1297
]
],
[
[
657,
63,
623
],
[
623,
24,
1297
]
],
[
[
657,
24,
971
],
[
971,
63,
1297
]
],
[
[
657,
24,
927
],
[
927,
... | [
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gi... |
DB00277 | DB00794 | 1,031 | 759 | [
"DDInter1791",
"DDInter1521"
] | Theophylline | Primidone | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
1031,
24,
759
]
],
[
[
1031,
24,
697
],
[
697,
40,
759
]
],
[
[
1031,
63,
362
],
[
362,
1,
759
]
],
[
[
1031,
24,
157
],
[
157,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Comp... |
DB00445 | DB14723 | 322 | 159 | [
"DDInter655",
"DDInter1026"
] | Epirubicin | Larotrectinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
322,
24,
159
]
],
[
[
322,
24,
479
],
[
479,
23,
159
]
],
[
[
322,
25,
318
],
[
318,
23,
159
]
],
[
[
322,
64,
1230
],
[
1230,
2... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Epirubicin may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cau... |
DB00393 | DB09054 | 854 | 384 | [
"DDInter1295",
"DDInter905"
] | Nimodipine | Idelalisib | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
854,
25,
384
]
],
[
[
854,
63,
58
],
[
58,
24,
384
]
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[
[
854,
24,
1512
],
[
1512,
24,
384
]
],
[
[
854,
1,
409
],
[
409,
24,
... | [
[
[
"Nimodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
"Alefacept",... | Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofen... |
DB00196 | DB12500 | 600 | 283 | [
"DDInter743",
"DDInter714"
] | Fluconazole | Fedratinib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
600,
24,
283
]
],
[
[
600,
23,
271
],
[
271,
23,
283
]
],
[
[
600,
23,
466
],
[
466,
62,
283
]
],
[
[
600,
25,
351
],
[
351,
23,... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Daroluta... |
DB00201 | DB09330 | 1,684 | 985 | [
"DDInter263",
"DDInter1352"
] | Caffeine | Osimertinib | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1684,
24,
985
]
],
[
[
1684,
23,
43
],
[
43,
24,
985
]
],
[
[
1684,
24,
663
],
[
663,
24,
985
]
],
[
[
1684,
63,
529
],
[
529,
2... | [
[
[
"Caffeine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Caffeine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Melatonin"
],
[
"M... | Caffeine may cause a minor interaction that can limit clinical effects when taken with Melatonin and Melatonin may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexat... |
DB00099 | DB00262 | 440 | 552 | [
"DDInter735",
"DDInter302"
] | Filgrastim | Carmustine | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Moderate | 1 | [
[
[
440,
24,
552
]
],
[
[
440,
24,
377
],
[
377,
63,
552
]
],
[
[
440,
63,
305
],
[
305,
24,
552
]
],
[
[
440,
25,
1064
],
[
1064,
2... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mitomycin"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Carmustine
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichi... |
DB00370 | DB06788 | 1,251 | 1,616 | [
"DDInter1230",
"DDInter864"
] | Mirtazapine | Histrelin | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1251,
24,
1616
]
],
[
[
1251,
23,
112
],
[
112,
23,
1616
]
],
[
[
1251,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
1251,
24,
603
],
[
603,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Mirtazapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Rom... |
DB01268 | DB09082 | 1,151 | 659 | [
"DDInter1731",
"DDInter1934"
] | Sunitinib | Vilanterol | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1151,
24,
659
]
],
[
[
1151,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1151,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1151,
24,
1296
],
[
1296,... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Az... |
DB00450 | DB00526 | 78 | 1,555 | [
"DDInter603",
"DDInter1355"
] | Droperidol | Oxaliplatin | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Major | 2 | [
[
[
78,
25,
1555
]
],
[
[
78,
64,
79
],
[
79,
24,
1555
]
],
[
[
78,
25,
1213
],
[
1213,
63,
1555
]
],
[
[
78,
24,
384
],
[
384,
63,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sorafenib"
],
[
"Sorafenib",
"{u} ma... | Droperidol may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Droperidol may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interac... |
DB00586 | DB06603 | 1,512 | 39 | [
"DDInter537",
"DDInter1387"
] | Diclofenac | Panobinostat | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1512,
25,
39
]
],
[
[
1512,
23,
479
],
[
479,
23,
39
]
],
[
[
1512,
63,
912
],
[
912,
24,
39
]
],
[
[
1512,
1,
282
],
[
282,
63,... | [
[
[
"Diclofenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Diclofenac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
"Donepezil",... | Diclofenac may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and In... |
DB01319 | DB06228 | 34 | 792 | [
"DDInter777",
"DDInter1609"
] | Fosamprenavir | Rivaroxaban | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
34,
24,
792
]
],
[
[
34,
6,
8374
],
[
8374,
45,
792
]
],
[
[
34,
21,
28703
],
[
28703,
60,
792
]
],
[
[
34,
63,
752
],
[
752,
24... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Fosamprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Fosamprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivaroxaban (Compound)
Fosamprenavir (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine... |
DB00624 | DB08870 | 1,561 | 850 | [
"DDInter1776",
"DDInter228"
] | Testosterone (topical) | Brentuximab vedotin | Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, an androstanoid, a C19-steroid and a 3-oxo-Delta(4) steroid. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1561,
24,
850
]
],
[
[
1561,
24,
267
],
[
267,
24,
850
]
],
[
[
1561,
40,
443
],
[
443,
24,
850
]
],
[
[
1561,
63,
245
],
[
245,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuxi... |
DB00431 | DB00915 | 1,503 | 1,170 | [
"DDInter1072",
"DDInter60"
] | Lindane | Amantadine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Moderate | 1 | [
[
[
1503,
24,
1170
]
],
[
[
1503,
24,
1369
],
[
1369,
40,
1170
]
],
[
[
1503,
21,
28762
],
[
28762,
60,
1170
]
],
[
[
1503,
63,
999
],
[
9... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amantadine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimantadine"
],
[
"... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Rimantadine and Rimantadine (Compound) resembles Amantadine (Compound)
Lindane (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Amantadine (Compound)
Lindane may cause a moderate interaction that coul... |
DB00087 | DB10583 | 599 | 949 | [
"DDInter41",
"DDInter415"
] | Alemtuzumab | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
599,
24,
949
]
],
[
[
599,
63,
550
],
[
550,
24,
949
]
],
[
[
599,
24,
589
],
[
589,
24,
949
]
],
[
[
599,
25,
1377
],
[
1377,
2... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Alemtuzumab may cause a moderate interaction that could exa... |
DB00202 | DB01082 | 190 | 1,448 | [
"DDInter1716",
"DDInter1713"
] | Succinylcholine | Streptomycin | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Major | 2 | [
[
[
190,
25,
1448
]
],
[
[
190,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
190,
24,
608
],
[
608,
23,
1448
]
],
[
[
190,
25,
361
],
[
361,
... | [
[
[
"Succinylcholine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Streptomycin"
]
],
[
[
"Succinylcholine",
"{u} (Compound) causes {v} (Side Effect)",
"Renal failure"
],
[
"Renal failure",
"{u} (Side Effect) is... | Succinylcholine (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when ta... |
DB00372 | DB11160 | 999 | 337 | [
"DDInter1793",
"DDInter1459"
] | Thiethylperazine | Phenyltoloxamine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
999,
24,
337
]
],
[
[
999,
63,
1594
],
[
1594,
24,
337
]
],
[
[
999,
24,
1511
],
[
1511,
24,
337
]
],
[
[
999,
25,
1311
],
[
1311,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamin... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Mep... |
DB00776 | DB12015 | 1,335 | 1,033 | [
"DDInter1360",
"DDInter53"
] | Oxcarbazepine | Alpelisib | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1335,
24,
1033
]
],
[
[
1335,
24,
1135
],
[
1135,
23,
1033
]
],
[
[
1335,
24,
951
],
[
951,
24,
1033
]
],
[
[
1335,
63,
837
],
[
837,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palb... |
DB00748 | DB09061 | 662 | 1,627 | [
"DDInter297",
"DDInter284"
] | Carbinoxamine | Cannabidiol | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
662,
24,
1627
]
],
[
[
662,
63,
1594
],
[
1594,
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]
],
[
[
662,
24,
516
],
[
516,
24,
1627
]
],
[
[
662,
24,
407
],
[
407,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine... |
DB11921 | DB12332 | 1,019 | 1,619 | [
"DDInter492",
"DDInter1626"
] | Deflazacort | Rucaparib | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1019,
24,
1619
]
],
[
[
1019,
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],
[
307,
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],
[
[
1019,
63,
259
],
[
259,
24,
1619
]
],
[
[
1019,
24,
151
],
[
151,
... | [
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Deflazacort",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Modafinil"
],
[
"Modafinil"... | Deflazacort may lead to a major life threatening interaction when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a m... |
DB08869 | DB08907 | 162 | 1,344 | [
"DDInter1773",
"DDInter280"
] | Tesamorelin | Canagliflozin | Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
162,
24,
1344
]
],
[
[
162,
63,
549
],
[
549,
1,
1344
]
],
[
[
162,
63,
176
],
[
176,
24,
1344
]
],
[
[
162,
24,
1296
],
[
1296,
... | [
[
[
"Tesamorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Tesamorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Tesamorelin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Tesamorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate... |
DB00982 | DB08899 | 1,517 | 129 | [
"DDInter991",
"DDInter649"
] | Isotretinoin | Enzalutamide | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1517,
24,
129
]
],
[
[
1517,
21,
29377
],
[
29377,
60,
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]
],
[
[
1517,
25,
1510
],
[
1510,
24,
129
]
],
[
[
1517,
24,
242
],
[
242,... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Isotretinoin",
"{u} (Compound) causes {v} (Side Effect)",
"Musculoskeletal pain"
],
[
"Musculoskeletal pain",
... | Isotretinoin (Compound) causes Musculoskeletal pain (Side Effect) and Musculoskeletal pain (Side Effect) is caused by Enzalutamide (Compound)
Isotretinoin may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when... |
DB08904 | DB10429 | 375 | 200 | [
"DDInter342",
"DDInter282"
] | Certolizumab pegol | Candida albicans | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
375,
24,
200
]
],
[
[
375,
64,
1096
],
[
1096,
24,
200
]
],
[
[
375,
25,
1019
],
[
1019,
63,
200
]
],
[
[
375,
25,
745
],
[
745,
... | [
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
... | Certolizumab pegol may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Certolizumab pegol may lead to a major life threatening interaction when taken with Deflazacort and... |
DB00365 | DB01156 | 839 | 593 | [
"DDInter842",
"DDInter252"
] | Grepafloxacin | Bupropion | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
839,
25,
593
]
],
[
[
839,
24,
1532
],
[
1532,
63,
593
]
],
[
[
839,
25,
126
],
[
126,
24,
593
]
],
[
[
839,
25,
1593
],
[
1593,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
"Ifosf... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Bupropion
Grepafloxacin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause... |
DB00031 | DB06692 | 20 | 930 | [
"DDInter1764",
"DDInter113"
] | Tenecteplase | Aprotinin | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). Since it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery. For this use, it is typically administered by injection. The goal o... | Moderate | 1 | [
[
[
20,
24,
930
]
],
[
[
20,
23,
944
],
[
944,
62,
582
],
[
582,
24,
930
]
],
[
[
20,
24,
804
],
[
804,
63,
582
],
[
582,
24,
930
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprotinin"
]
],
[
[
"Tenecteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Reteplase and Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Aprotinin
Tenecteplase ... |
DB00472 | DB08881 | 758 | 868 | [
"DDInter758",
"DDInter1925"
] | Fluoxetine | Vemurafenib | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
758,
25,
868
]
],
[
[
758,
6,
8374
],
[
8374,
45,
868
]
],
[
[
758,
7,
3727
],
[
3727,
46,
868
]
],
[
[
758,
18,
4187
],
[
4187,
... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Fluoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Fluoxetine (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Vemurafenib (Compound)
Fluoxetine (Compound) downregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Vemurafenib (Compound)
Fluoxetine ... |
DB00398 | DB09074 | 79 | 1,362 | [
"DDInter1702",
"DDInter1327"
] | Sorafenib | Olaparib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
79,
24,
1362
]
],
[
[
79,
24,
627
],
[
627,
63,
1362
]
],
[
[
79,
24,
896
],
[
896,
24,
1362
]
],
[
[
79,
64,
576
],
[
576,
24,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir and Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide... |
DB01319 | DB11718 | 34 | 927 | [
"DDInter777",
"DDInter640"
] | Fosamprenavir | Encorafenib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
34,
25,
927
]
],
[
[
34,
24,
659
],
[
659,
24,
927
]
],
[
[
34,
63,
1324
],
[
1324,
24,
927
]
],
[
[
34,
64,
613
],
[
613,
24,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[
"Vil... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone a... |
DB00562 | DB11348 | 1,014 | 1,065 | [
"DDInter188",
"DDInter279"
] | Benzthiazide | Calcium Phosphate | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
1014,
24,
1065
]
],
[
[
1014,
23,
1620
],
[
1620,
24,
1065
]
],
[
[
1014,
1,
359
],
[
359,
24,
1065
]
],
[
[
1014,
62,
964
],
[
964,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracycline"
... | Benzthiazide may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Benzthiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate i... |
DB04946 | DB06595 | 924 | 1,491 | [
"DDInter907",
"DDInter1214"
] | Iloperidone | Midostaurin | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
924,
25,
1491
]
],
[
[
924,
62,
112
],
[
112,
23,
1491
]
],
[
[
924,
24,
761
],
[
761,
24,
1491
]
],
[
[
924,
64,
888
],
[
888,
... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Iloperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Iloperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and ... |
DB01041 | DB04837 | 770 | 649 | [
"DDInter1789",
"DDInter407"
] | Thalidomide | Clofedanol | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
770,
24,
649
]
],
[
[
770,
24,
1376
],
[
1376,
24,
649
]
],
[
[
770,
63,
21
],
[
21,
24,
649
]
],
[
[
770,
64,
675
],
[
675,
40,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Amitripty... |
DB00087 | DB00363 | 599 | 695 | [
"DDInter41",
"DDInter419"
] | Alemtuzumab | Clozapine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
599,
25,
695
]
],
[
[
599,
24,
1001
],
[
1001,
64,
695
]
],
[
[
599,
63,
1172
],
[
1172,
25,
695
]
],
[
[
599,
24,
552
],
[
552,
... | [
[
[
"Alemtuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],
[
"Mech... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine may lead to a major life threatening interaction when taken with Clozapine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ibritumomab tiuxetan and ... |
DB00582 | DB12010 | 1,622 | 214 | [
"DDInter1946",
"DDInter785"
] | Voriconazole | Fostamatinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
1622,
25,
214
]
],
[
[
1622,
25,
976
],
[
976,
24,
214
]
],
[
[
1622,
24,
723
],
[
723,
24,
214
]
],
[
[
1622,
63,
10
],
[
10,
2... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
... | Voriconazole may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant ma... |
DB00188 | DB11003 | 168 | 748 | [
"DDInter222",
"DDInter100"
] | Bortezomib | Anthrax vaccine | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
168,
24,
748
]
],
[
[
168,
24,
322
],
[
322,
24,
748
]
],
[
[
168,
25,
676
],
[
676,
63,
748
]
],
[
[
168,
64,
1057
],
[
1057,
2... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Bortezomib may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib m... |
DB01241 | DB08899 | 1,206 | 129 | [
"DDInter812",
"DDInter649"
] | Gemfibrozil | Enzalutamide | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1206,
24,
129
]
],
[
[
1206,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1206,
21,
29377
],
[
29377,
60,
129
]
],
[
[
1206,
63,
1512
],
[
1512... | [
[
[
"Gemfibrozil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Gemfibrozil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Gemfibrozil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Gemfibrozil (Compound) causes Musculoskeletal pain (Side Effect) and Musculoskeletal pain (Side Effect) is caused by Enzalutamide (Compound)
Gemfibrozil may cause a moderate interaction that could exacerbate diseases when t... |
DB01095 | DB11901 | 671 | 913 | [
"DDInter769",
"DDInter107"
] | Fluvastatin | Apalutamide | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
671,
24,
913
]
],
[
[
671,
63,
112
],
[
112,
23,
913
]
],
[
[
671,
63,
600
],
[
600,
24,
913
]
],
[
[
671,
24,
1250
],
[
1250,
2... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB00745 | DB00907 | 307 | 290 | [
"DDInter1236",
"DDInter427"
] | Modafinil | Cocaine (topical) | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Major | 2 | [
[
[
307,
25,
290
]
],
[
[
307,
6,
2437
],
[
2437,
45,
290
]
],
[
[
307,
21,
28741
],
[
28741,
60,
290
]
],
[
[
307,
24,
629
],
[
629,
... | [
[
[
"Modafinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
"{u} (Gene) is bound by {v} (Compound)",
"Cocaine"
... | Modafinil may lead to a major life threatening interaction when taken with Cocaine
Modafinil (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Cocaine (Compound)
Modafinil (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Compound)
Modafinil may cause a moderate inte... |
DB00284 | DB01583 | 1,647 | 624 | [
"DDInter11",
"DDInter1075"
] | Acarbose | Liotrix | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Moderate | 1 | [
[
[
1647,
24,
624
]
],
[
[
1647,
63,
1152
],
[
1152,
1,
624
]
],
[
[
1647,
24,
542
],
[
542,
40,
624
]
],
[
[
1647,
21,
28898
],
[
28898,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[
"... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Liotrix (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine (Compound) resembles Liotrix (Compound)
... |
DB00454 | DB01105 | 1,349 | 222 | [
"DDInter1150",
"DDInter1665"
] | Meperidine | Sibutramine | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
1349,
25,
222
]
],
[
[
1349,
6,
8374
],
[
8374,
45,
222
]
],
[
[
1349,
21,
28698
],
[
28698,
60,
222
]
],
[
[
1349,
24,
159
],
[
159,
... | [
[
[
"Meperidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Meperidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Sibutr... | Meperidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Meperidine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and L... |
DB08899 | DB09049 | 129 | 1,135 | [
"DDInter649",
"DDInter1261"
] | Enzalutamide | Naloxegol | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
129,
25,
1135
]
],
[
[
129,
64,
33
],
[
33,
23,
1135
]
],
[
[
129,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
129,
63,
495
],
[
495,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiodarone",
"{u... | Enzalutamide may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Enzalutamide may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor interact... |
DB00209 | DB00524 | 352 | 811 | [
"DDInter1886",
"DDInter1199"
] | Trospium | Metolazone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Minor | 0 | [
[
[
352,
23,
811
]
],
[
[
352,
23,
1605
],
[
1605,
40,
811
]
],
[
[
352,
23,
1014
],
[
1014,
1,
811
]
],
[
[
352,
21,
28850
],
[
28850,
... | [
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
]
],
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
],
[
"Ind... | Trospium may cause a minor interaction that can limit clinical effects when taken with Indapamide and Indapamide (Compound) resembles Metolazone (Compound)
Trospium may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resembles Metolazone (Compound)
Tros... |
DB00526 | DB14509 | 1,555 | 1,399 | [
"DDInter1355",
"DDInter1081"
] | Oxaliplatin | Lithium carbonate | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1555,
24,
1399
]
],
[
[
1555,
63,
589
],
[
589,
23,
1399
]
],
[
[
1555,
24,
1374
],
[
1374,
24,
1399
]
],
[
[
1555,
63,
1010
],
[
1010... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and ... |
DB00912 | DB06717 | 473 | 875 | [
"DDInter1581",
"DDInter778"
] | Repaglinide | Fosaprepitant | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
473,
24,
875
]
],
[
[
473,
63,
723
],
[
723,
1,
875
]
],
[
[
473,
21,
29340
],
[
29340,
60,
875
]
],
[
[
473,
24,
222
],
[
222,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Repaglinide (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Fosaprepitant (Compound)
Repagl... |
DB00526 | DB11837 | 1,555 | 1,297 | [
"DDInter1355",
"DDInter1351"
] | Oxaliplatin | Osilodrostat | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1555,
24,
1297
]
],
[
[
1555,
24,
112
],
[
112,
23,
1297
]
],
[
[
1555,
23,
1247
],
[
1247,
23,
1297
]
],
[
[
1555,
24,
623
],
[
623,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazol... |
DB00816 | DB01044 | 1,674 | 246 | [
"DDInter1346",
"DDInter809"
] | Orciprenaline | Gatifloxacin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
1674,
25,
246
]
],
[
[
1674,
24,
739
],
[
739,
1,
246
]
],
[
[
1674,
64,
1176
],
[
1176,
1,
246
]
],
[
[
1674,
25,
945
],
[
945,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
"... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Orciprenaline may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compoun... |
DB08908 | DB15762 | 713 | 725 | [
"DDInter564",
"DDInter1644"
] | Dimethyl fumarate | Satralizumab | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
713,
24,
725
]
],
[
[
713,
24,
1362
],
[
1362,
24,
725
]
],
[
[
713,
63,
372
],
[
372,
24,
725
]
],
[
[
713,
64,
1066
],
[
1066,
... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Clofarabi... |
DB00180 | DB00834 | 1,351 | 932 | [
"DDInter749",
"DDInter1215"
] | Flunisolide | Mifepristone | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
1351,
25,
932
]
],
[
[
1351,
6,
1899
],
[
1899,
45,
932
]
],
[
[
1351,
7,
6314
],
[
6314,
46,
932
]
],
[
[
1351,
18,
8733
],
[
8733,
... | [
[
[
"Flunisolide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Flunisolide",
"{u} (Compound) binds {v} (Gene)",
"NR3C1"
],
[
"NR3C1",
"{u} (Gene) is bound by {v} (Compound)",
"Mifep... | Flunisolide (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is bound by Mifepristone (Compound)
Flunisolide (Compound) upregulates TLR4 (Gene) and TLR4 (Gene) is upregulated by Mifepristone (Compound)
Flunisolide (Compound) downregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Mifepristone (Compound)
Flunisolide... |
DB01087 | DB06402 | 1,520 | 1,079 | [
"DDInter1520",
"DDInter1756"
] | Primaquine | Telavancin | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
1520,
24,
1079
]
],
[
[
1520,
21,
28722
],
[
28722,
60,
1079
]
],
[
[
1520,
62,
112
],
[
112,
23,
1079
]
],
[
[
1520,
24,
657
],
[
657... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Primaquine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by ... | Primaquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Telavancin (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
... |
DB11901 | DB11943 | 913 | 255 | [
"DDInter107",
"DDInter495"
] | Apalutamide | Delafloxacin | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
913,
24,
255
]
],
[
[
913,
63,
63
],
[
63,
23,
255
]
],
[
[
913,
64,
613
],
[
613,
23,
255
]
],
[
[
913,
63,
1512
],
[
1512,
24,... | [
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
],
... | Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Apalutamide may lead to a major life threatening interaction when taken with Irinotecan and Irinotecan may caus... |
DB00047 | DB09043 | 176 | 135 | [
"DDInter932",
"DDInter36"
] | Insulin glargine | Albiglutide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
176,
24,
135
]
],
[
[
176,
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1103
],
[
1103,
23,
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]
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[
[
176,
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],
[
624,
24,
135
]
],
[
[
176,
25,
646
],
[
646,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
... | Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and ... |
DB00014 | DB00398 | 521 | 79 | [
"DDInter839",
"DDInter1702"
] | Goserelin | Sorafenib | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
521,
24,
79
]
],
[
[
521,
21,
29209
],
[
29209,
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79
]
],
[
[
521,
24,
549
],
[
549,
62,
79
]
],
[
[
521,
23,
1247
],
[
1247,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is caused by... | Goserelin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Sorafenib (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a minor interaction that can limit clinical effects when taken with Sorafeni... |
DB00757 | DB14509 | 1,166 | 1,399 | [
"DDInter581",
"DDInter1081"
] | Dolasetron | Lithium carbonate | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
1166,
25,
1399
]
],
[
[
1166,
25,
1374
],
[
1374,
24,
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]
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[
[
1166,
64,
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],
[
506,
24,
1399
]
],
[
[
1166,
63,
475
],
[
475,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
],
[
"Abiraterone",
... | Dolasetron may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Dolasetron may lead to a major life threatening interaction when taken with Dextromethorphan and Dextromethorphan may ... |
DB00934 | DB01218 | 413 | 1,493 | [
"DDInter1124",
"DDInter852"
] | Maprotiline | Halofantrine | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
413,
25,
1493
]
],
[
[
413,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
413,
18,
2183
],
[
2183,
57,
1493
]
],
[
[
413,
21,
28810
],
[
2881... | [
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Hal... | Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Maprotiline (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Halofantrine (Compound)
Maprotiline (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is cau... |
DB01254 | DB09049 | 1,213 | 1,135 | [
"DDInter484",
"DDInter1261"
] | Dasatinib | Naloxegol | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
1213,
23,
1135
]
],
[
[
1213,
64,
33
],
[
33,
23,
1135
]
],
[
[
1213,
24,
495
],
[
495,
23,
1135
]
],
[
[
1213,
24,
971
],
[
971,
... | [
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amiodarone",
... | Dasatinib may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine and Ezogabine may cause a minor... |
DB01261 | DB09128 | 170 | 1,241 | [
"DDInter1679",
"DDInter231"
] | Sitagliptin | Brexpiprazole | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
170,
24,
1241
]
],
[
[
170,
24,
129
],
[
129,
24,
1241
]
],
[
[
170,
24,
1296
],
[
1296,
63,
1241
]
],
[
[
170,
63,
1179
],
[
1179,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degl... |
DB00188 | DB00215 | 168 | 1,230 | [
"DDInter222",
"DDInter388"
] | Bortezomib | Citalopram | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Minor | 0 | [
[
[
168,
23,
1230
]
],
[
[
168,
23,
318
],
[
318,
40,
1230
]
],
[
[
168,
6,
7950
],
[
7950,
45,
1230
]
],
[
[
168,
18,
5587
],
[
5587,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Citalopram"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Escitalopram"
],
[
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Escitalopram and Escitalopram (Compound) resembles Citalopram (Compound)
Bortezomib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Citalopram (Compound)
Bortezomib (Compound) downregulates SCAND1 (Gene) and SCAND1 (Ge... |
DB00861 | DB09133 | 914 | 1,527 | [
"DDInter551",
"DDInter965"
] | Diflunisal | Iothalamic acid | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
914,
25,
1527
]
],
[
[
914,
24,
116
],
[
116,
63,
1527
]
],
[
[
914,
63,
1512
],
[
1512,
25,
1527
]
],
[
[
914,
24,
848
],
[
848,
... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
],
[
"Iod... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131 and Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac a... |
DB00030 | DB00877 | 1,685 | 629 | [
"DDInter934",
"DDInter1678"
] | Insulin human | Sirolimus | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1685,
24,
629
]
],
[
[
1685,
24,
1438
],
[
1438,
24,
629
]
],
[
[
1685,
24,
1476
],
[
1476,
63,
629
]
],
[
[
1685,
24,
609
],
[
609,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Bri... |
DB06788 | DB11110 | 1,616 | 603 | [
"DDInter864",
"DDInter1115"
] | Histrelin | Magnesium citrate | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1616,
24,
603
]
],
[
[
1616,
64,
57
],
[
57,
24,
603
]
],
[
[
1616,
63,
789
],
[
789,
24,
603
]
],
[
[
1616,
24,
484
],
[
484,
6... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Histrelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Histrelin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Fosca... |
DB01124 | DB01432 | 1,411 | 857 | [
"DDInter1828",
"DDInter368"
] | Tolbutamide | Cholestyramine | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water. | Moderate | 1 | [
[
[
1411,
24,
857
]
],
[
[
1411,
63,
1512
],
[
1512,
23,
857
]
],
[
[
1411,
24,
1264
],
[
1264,
23,
857
]
],
[
[
1411,
63,
870
],
[
870,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholestyramine"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a minor interaction that can limit clinical effects when taken with Cholestyramine
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxep... |
DB00252 | DB01229 | 362 | 973 | [
"DDInter1460",
"DDInter1377"
] | Phenytoin | Paclitaxel | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
362,
24,
973
]
],
[
[
362,
24,
310
],
[
310,
63,
973
]
],
[
[
362,
6,
7524
],
[
7524,
45,
973
]
],
[
[
362,
7,
6952
],
[
6952,
4... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Phenytoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Phenytoin (Compoun... |
DB04946 | DB12010 | 924 | 214 | [
"DDInter907",
"DDInter785"
] | Iloperidone | Fostamatinib | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
924,
24,
214
]
],
[
[
924,
64,
51
],
[
51,
24,
214
]
],
[
[
924,
25,
1250
],
[
1250,
24,
214
]
],
[
[
924,
63,
1144
],
[
1144,
2... | [
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daunorubicin"
],
[
"Daun... | Iloperidone may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Iloperidone may lead to a major life threatening interaction when taken with Pazopanib and Pazopanib may cause a moderat... |
DB01112 | DB08938 | 665 | 1,384 | [
"DDInter335",
"DDInter1112"
] | Cefuroxime | Magaldrate | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
665,
24,
1384
]
],
[
[
665,
63,
752
],
[
752,
23,
1384
]
],
[
[
665,
40,
1462
],
[
1462,
24,
1384
]
],
[
[
665,
63,
1096
],
[
1096,
... | [
[
[
"Cefuroxime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Cefuroxime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[
... | Cefuroxime may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Cefuroxime (Compound) resembles Cefditoren (Compound) and Cefditoren may cause a moderate interaction that could e... |
DB00370 | DB01254 | 1,251 | 1,213 | [
"DDInter1230",
"DDInter484"
] | Mirtazapine | Dasatinib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1251,
24,
1213
]
],
[
[
1251,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1251,
6,
3576
],
[
3576,
57,
1213
]
],
[
[
1251,
21,
28882
],
[
288... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Mirtazapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Mirtazapine (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is downregulated by Dasatinib (Compound)
Mirtazapine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused ... |
DB00083 | DB01069 | 677 | 401 | [
"DDInter225",
"DDInter1533"
] | Botulinum toxin type A | Promethazine | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
677,
24,
401
]
],
[
[
677,
24,
1264
],
[
1264,
63,
401
]
],
[
[
677,
24,
104
],
[
104,
24,
401
]
],
[
[
677,
24,
1264
],
[
1264,
... | [
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"D... | Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB01172 | DB05260 | 416 | 1,329 | [
"DDInter1004",
"DDInter804"
] | Kanamycin | Gallium nitrate | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for... | Major | 2 | [
[
[
416,
25,
1329
]
],
[
[
416,
21,
29035
],
[
29035,
60,
1329
]
],
[
[
416,
63,
1555
],
[
1555,
24,
1329
]
],
[
[
416,
24,
712
],
[
712,
... | [
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gallium nitrate"
]
],
[
[
"Kanamycin",
"{u} (Compound) causes {v} (Side Effect)",
"Hearing impaired"
],
[
"Hearing impaired",
"{u} (Side Effect) is ca... | Kanamycin (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Gallium nitrate (Compound)
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when... |
DB00286 | DB09564 | 380 | 1,296 | [
"DDInter439",
"DDInter930"
] | Conjugated estrogens | Insulin degludec | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
380,
24,
1296
]
],
[
[
380,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
380,
24,
1385
],
[
1385,
63,
1296
]
],
[
[
380,
40,
559
],
[
559,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"T... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when take... |
DB00590 | DB09098 | 1,433 | 98 | [
"DDInter592",
"DDInter1700"
] | Doxazosin | Somatrem | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1433,
24,
98
]
],
[
[
1433,
24,
159
],
[
159,
63,
98
]
],
[
[
1433,
24,
1573
],
[
1573,
24,
98
]
],
[
[
1433,
40,
479
],
[
479,
... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Pred... |
DB00855 | DB01069 | 213 | 401 | [
"DDInter72",
"DDInter1533"
] | Aminolevulinic acid | Promethazine | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Major | 2 | [
[
[
213,
25,
401
]
],
[
[
213,
21,
28787
],
[
28787,
60,
401
]
],
[
[
213,
25,
1247
],
[
1247,
23,
401
]
],
[
[
213,
64,
1028
],
[
1028,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
]
],
[
[
"Aminolevulinic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) ... | Aminolevulinic acid (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Promethazine (Compound)
Aminolevulinic acid may lead to a major life threatening interaction when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when t... |
DB00641 | DB09115 | 467 | 505 | [
"DDInter1675",
"DDInter559"
] | Simvastatin | Diiodohydroxyquinoline | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
467,
24,
505
]
],
[
[
467,
24,
1593
],
[
1593,
24,
505
]
],
[
[
467,
25,
1510
],
[
1510,
24,
505
]
],
[
[
467,
63,
168
],
[
168,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Simvastatin may lead to a major life threatening interaction when taken with Teriflunomide and Teri... |
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