drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB04868 | DB09237 | 478 | 1,586 | [
"DDInter1293",
"DDInter1045"
] | Nilotinib | Levamlodipine | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
478,
24,
1586
]
],
[
[
478,
23,
466
],
[
466,
62,
1586
]
],
[
[
478,
24,
578
],
[
578,
23,
1586
]
],
[
[
478,
63,
870
],
[
870,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticag... |
DB00502 | DB01001 | 1,300 | 688 | [
"DDInter853",
"DDInter1632"
] | Haloperidol | Salbutamol | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1300,
24,
688
]
],
[
[
1300,
24,
874
],
[
874,
24,
688
]
],
[
[
1300,
25,
1148
],
[
1148,
63,
688
]
],
[
[
1300,
6,
8374
],
[
8374,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Haloperidol may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenaline ma... |
DB00352 | DB01118 | 482 | 33 | [
"DDInter1814",
"DDInter76"
] | Tioguanine | Amiodarone | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
482,
24,
33
]
],
[
[
482,
24,
540
],
[
540,
1,
33
]
],
[
[
482,
21,
29544
],
[
29544,
60,
33
]
],
[
[
482,
24,
597
],
[
597,
24,... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Tioguanine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Amiodarone (Compound)
Tioguanine may cause a moder... |
DB00880 | DB01246 | 359 | 820 | [
"DDInter360",
"DDInter45"
] | Chlorothiazide | Alimemazine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
359,
24,
820
]
],
[
[
359,
24,
104
],
[
104,
40,
820
]
],
[
[
359,
24,
401
],
[
401,
24,
820
]
],
[
[
359,
21,
28741
],
[
28741,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate inter... |
DB00252 | DB09043 | 362 | 135 | [
"DDInter1460",
"DDInter36"
] | Phenytoin | Albiglutide | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
362,
24,
135
]
],
[
[
362,
24,
126
],
[
126,
23,
135
]
],
[
[
362,
24,
870
],
[
870,
24,
135
]
],
[
[
362,
63,
176
],
[
176,
24,... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludroco... |
DB00697 | DB01088 | 876 | 714 | [
"DDInter1821",
"DDInter908"
] | Tizanidine | Iloprost | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Major | 2 | [
[
[
876,
25,
714
]
],
[
[
876,
64,
1648
],
[
1648,
24,
714
]
],
[
[
876,
25,
1637
],
[
1637,
63,
714
]
],
[
[
876,
24,
222
],
[
222,
... | [
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloprost"
]
],
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aldesleukin"
],
[
"Aldesleukin",
"{u} m... | Tizanidine may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Tizanidine may lead to a major life threatening interaction when taken with Amyl Nitrite and Amyl Nitrite may cause a moderate ... |
DB00586 | DB01028 | 1,512 | 1,332 | [
"DDInter537",
"DDInter1179"
] | Diclofenac | Methoxyflurane | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Moderate | 1 | [
[
[
1512,
24,
1332
]
],
[
[
1512,
6,
7950
],
[
7950,
45,
1332
]
],
[
[
1512,
24,
1448
],
[
1448,
63,
1332
]
],
[
[
1512,
24,
50
],
[
50,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxyflurane"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compoun... | Diclofenac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Methoxyflurane (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Diclof... |
DB00802 | DB09054 | 1,322 | 384 | [
"DDInter43",
"DDInter905"
] | Alfentanil | Idelalisib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1322,
25,
384
]
],
[
[
1322,
25,
222
],
[
222,
23,
384
]
],
[
[
1322,
63,
888
],
[
888,
24,
384
]
],
[
[
1322,
64,
600
],
[
600,
... | [
[
[
"Alfentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Alfentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",
"{u}... | Alfentanil may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a ... |
DB00363 | DB11986 | 695 | 484 | [
"DDInter419",
"DDInter648"
] | Clozapine | Entrectinib | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
695,
25,
484
]
],
[
[
695,
23,
112
],
[
112,
23,
484
]
],
[
[
695,
24,
222
],
[
222,
23,
484
]
],
[
[
695,
25,
774
],
[
774,
24,... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Clozapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Clozapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibu... |
DB00472 | DB01067 | 758 | 959 | [
"DDInter758",
"DDInter826"
] | Fluoxetine | Glipizide | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
758,
24,
959
]
],
[
[
758,
63,
245
],
[
245,
40,
959
]
],
[
[
758,
24,
1411
],
[
1411,
1,
959
]
],
[
[
758,
6,
8374
],
[
8374,
4... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB01169 | DB08864 | 57 | 786 | [
"DDInter120",
"DDInter1595"
] | Arsenic trioxide | Rilpivirine | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Major | 2 | [
[
[
57,
25,
786
]
],
[
[
57,
6,
8374
],
[
8374,
45,
786
]
],
[
[
57,
62,
112
],
[
112,
23,
786
]
],
[
[
57,
64,
918
],
[
918,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilpivirine"
]
],
[
[
"Arsenic trioxide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Arsenic trioxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rilpivirine
Ar... |
DB00054 | DB01088 | 1,432 | 714 | [
"DDInter6",
"DDInter908"
] | Abciximab | Iloprost | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1432,
24,
714
]
],
[
[
1432,
23,
539
],
[
539,
62,
714
]
],
[
[
1432,
24,
383
],
[
383,
24,
714
]
],
[
[
1432,
25,
1226
],
[
1226,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Abciximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Cap... | Abciximab may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Iloprost
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan... |
DB00361 | DB01033 | 134 | 328 | [
"DDInter1939",
"DDInter1156"
] | Vinorelbine | Mercaptopurine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
134,
24,
328
]
],
[
[
134,
5,
11555
],
[
11555,
44,
328
]
],
[
[
134,
7,
8155
],
[
8155,
45,
328
]
],
[
[
134,
21,
28681
],
[
28681,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Vinorelbine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (... | Vinorelbine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Vinorelbine (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is bound by Mercaptopurine (Compound)
Vinorelbine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Si... |
DB00065 | DB09570 | 581 | 1,480 | [
"DDInter923",
"DDInter1002"
] | Infliximab | Ixazomib | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Major | 2 | [
[
[
581,
25,
1480
]
],
[
[
581,
24,
987
],
[
987,
63,
1480
]
],
[
[
581,
63,
268
],
[
268,
24,
1480
]
],
[
[
581,
25,
453
],
[
453,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixazomib"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live anti... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Infliximab may cause a moderate interact... |
DB00553 | DB11363 | 92 | 1,276 | [
"DDInter1177",
"DDInter39"
] | Methoxsalen | Alectinib | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
92,
24,
1276
]
],
[
[
92,
63,
612
],
[
612,
24,
1276
]
],
[
[
92,
24,
663
],
[
663,
24,
1276
]
],
[
[
92,
25,
213
],
[
213,
25,
... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
],
[
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin and Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and M... |
DB00196 | DB09122 | 600 | 1,613 | [
"DDInter743",
"DDInter1409"
] | Fluconazole | Peginterferon beta-1a | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
600,
24,
1613
]
],
[
[
600,
24,
671
],
[
671,
24,
1613
]
],
[
[
600,
23,
1627
],
[
1627,
24,
1613
]
],
[
[
600,
25,
975
],
[
975,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Cannabid... |
DB00014 | DB06203 | 521 | 1,002 | [
"DDInter839",
"DDInter51"
] | Goserelin | Alogliptin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
521,
24,
1002
]
],
[
[
521,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
521,
21,
28778
],
[
28778,
60,
1002
]
],
[
[
521,
24,
401
],
[
401,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Goserelin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Alogliptin (Compound)
Goserelin may cause a mode... |
DB01177 | DB12245 | 77 | 823 | [
"DDInter904",
"DDInter1863"
] | Idarubicin | Triclabendazole | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
77,
24,
823
]
],
[
[
77,
62,
1247
],
[
1247,
23,
823
]
],
[
[
77,
24,
1612
],
[
1612,
24,
823
]
],
[
[
77,
63,
1010
],
[
1010,
2... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Idarubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],... | Idarubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsa... |
DB06792 | DB12035 | 1,606 | 943 | [
"DDInter1023",
"DDInter1641"
] | Lanthanum carbonate | Sarecycline | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1606,
24,
943
]
],
[
[
1606,
63,
1596
],
[
1596,
24,
943
]
],
[
[
1606,
24,
428
],
[
428,
63,
943
]
],
[
[
1606,
63,
1596
],
[
1596,
... | [
[
[
"Lanthanum carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Lanthanum carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
... | Lanthanum carbonate may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Lanthanum carbonate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumara... |
DB00261 | DB00640 | 702 | 1,585 | [
"DDInter93",
"DDInter31"
] | Anagrelide | Adenosine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Major | 2 | [
[
[
702,
25,
1585
]
],
[
[
702,
18,
2183
],
[
2183,
57,
1585
]
],
[
[
702,
21,
28890
],
[
28890,
60,
1585
]
],
[
[
702,
24,
578
],
[
578,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Adenosine"
]
],
[
[
"Anagrelide",
"{u} (Compound) downregulates {v} (Gene)",
"CDC20"
],
[
"CDC20",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Anagrelide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Adenosine (Compound)
Anagrelide (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Adenosine (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases... |
DB00598 | DB00620 | 1,523 | 175 | [
"DDInter1013",
"DDInter1855"
] | Labetalol | Triamcinolone | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
1523,
24,
175
]
],
[
[
1523,
24,
1573
],
[
1573,
1,
175
]
],
[
[
1523,
24,
617
],
[
617,
40,
175
]
],
[
[
1523,
63,
251
],
[
251,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compou... |
DB00046 | DB00359 | 1,179 | 161 | [
"DDInter940",
"DDInter1721"
] | Insulin lispro | Sulfadiazine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Moderate | 1 | [
[
[
1179,
24,
161
]
],
[
[
1179,
24,
1029
],
[
1029,
40,
161
]
],
[
[
1179,
24,
1560
],
[
1560,
24,
161
]
],
[
[
1179,
24,
959
],
[
959,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxazole"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfadiazine (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate in... |
DB00696 | DB08865 | 826 | 1,593 | [
"DDInter665",
"DDInter448"
] | Ergotamine | Crizotinib | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
826,
24,
1593
]
],
[
[
826,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
826,
21,
28658
],
[
28658,
60,
1593
]
],
[
[
826,
24,
283
],
[
283,
... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Ergotamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Ergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Ergotamine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Crizotinib (Compound)
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB01576 | DB09268 | 93 | 1,662 | [
"DDInter526",
"DDInter1464"
] | Dextroamphetamine | Picosulfuric acid | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
93,
24,
1662
]
],
[
[
93,
40,
73
],
[
73,
24,
1662
]
],
[
[
93,
74,
1466
],
[
1466,
24,
1662
]
],
[
[
93,
63,
820
],
[
820,
24,
... | [
[
[
"Dextroamphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Dextroamphetamine",
"{u} (Compound) resembles {v} (Compound)",
"Phentermine"
],
[
"Phentermine",
"... | Dextroamphetamine (Compound) resembles Phentermine (Compound) and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Dextroamphetamine (Compound) resembles Phenylpropanolamine (Compound) and Dextroamphetamine may cause a moderate interaction that could exacerba... |
DB00717 | DB11901 | 1,197 | 913 | [
"DDInter1312",
"DDInter107"
] | Norethisterone | Apalutamide | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1197,
24,
913
]
],
[
[
1197,
63,
600
],
[
600,
24,
913
]
],
[
[
1197,
1,
35
],
[
35,
24,
913
]
],
[
[
1197,
24,
609
],
[
609,
24... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
]... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Norethisterone (Compound) resembles Quinestrol (Compound) and Quinestrol may cause a moderate interaction... |
DB00472 | DB01064 | 758 | 1,148 | [
"DDInter758",
"DDInter987"
] | Fluoxetine | Isoprenaline | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
758,
24,
1148
]
],
[
[
758,
24,
480
],
[
480,
24,
1148
]
],
[
[
758,
18,
2183
],
[
2183,
57,
1148
]
],
[
[
758,
21,
29316
],
[
29316,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Fluoxetine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Isoprenaline (Compound)
... |
DB00323 | DB01069 | 1,062 | 401 | [
"DDInter1829",
"DDInter1533"
] | Tolcapone | Promethazine | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1062,
24,
401
]
],
[
[
1062,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1062,
24,
104
],
[
104,
24,
401
]
],
[
[
1062,
6,
6017
],
[
6017,
... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazi... |
DB00261 | DB01155 | 702 | 872 | [
"DDInter93",
"DDInter813"
] | Anagrelide | Gemifloxacin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Major | 2 | [
[
[
702,
25,
872
]
],
[
[
702,
25,
739
],
[
739,
1,
872
]
],
[
[
702,
24,
1467
],
[
1467,
1,
872
]
],
[
[
702,
25,
945
],
[
945,
40,... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Anagrelide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Gemifloxacin (Compound)
Anagrelide ... |
DB00106 | DB04948 | 618 | 1,084 | [
"DDInter4",
"DDInter1083"
] | Abarelix | Lofexidine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
618,
24,
1084
]
],
[
[
618,
23,
112
],
[
112,
23,
1084
]
],
[
[
618,
24,
688
],
[
688,
24,
1084
]
],
[
[
618,
24,
1228
],
[
1228,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lofexidine
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutam... |
DB01101 | DB08880 | 60 | 1,510 | [
"DDInter285",
"DDInter1771"
] | Capecitabine | Teriflunomide | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
60,
25,
1510
]
],
[
[
60,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
60,
24,
221
],
[
221,
63,
1510
]
],
[
[
60,
24,
1136
],
[
1136,
... | [
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vita... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 ... |
DB00734 | DB00927 | 1,664 | 1,559 | [
"DDInter1605",
"DDInter712"
] | Risperidone | Famotidine | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
1664,
24,
1559
]
],
[
[
1664,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
1664,
24,
286
],
[
286,
62,
1559
]
],
[
[
1664,
23,
112
],
[
112... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Risperidone",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is caus... | Risperidone (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when ta... |
DB01394 | DB12500 | 1,554 | 283 | [
"DDInter431",
"DDInter714"
] | Colchicine | Fedratinib | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1554,
25,
283
]
],
[
[
1554,
25,
351
],
[
351,
23,
283
]
],
[
[
1554,
64,
1419
],
[
1419,
24,
283
]
],
[
[
1554,
63,
63
],
[
63,
... | [
[
[
"Colchicine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Colchicine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",
"{u} m... | Colchicine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Colchicine may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interactio... |
DB00444 | DB08826 | 63 | 1,292 | [
"DDInter1765",
"DDInter489"
] | Teniposide | Deferiprone | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
63,
25,
1292
]
],
[
[
63,
18,
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],
[
2215,
57,
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],
[
[
63,
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[
28809,
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1292
]
],
[
[
63,
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1017
],
[
1017,
... | [
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Teniposide",
"{u} (Compound) downregulates {v} (Gene)",
"HSPA8"
],
[
"HSPA8",
"{u} (Gene) is downregulated by {v} (Compound)",... | Teniposide (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Teniposide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Lor... |
DB00286 | DB01041 | 380 | 770 | [
"DDInter439",
"DDInter1789"
] | Conjugated estrogens | Thalidomide | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
380,
25,
770
]
],
[
[
380,
25,
1668
],
[
1668,
1,
770
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[
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380,
6,
7950
],
[
7950,
45,
770
]
],
[
[
380,
21,
29598
],
[
29598,
... | [
[
[
"Conjugated estrogens",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Conjugated estrogens",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenalidomide"
],
[
"Le... | Conjugated estrogens may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Conjugated estrogens (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thalidomide (Compound)
Conjugated estrogens (Compound) causes Cellulitis (Side... |
DB00480 | DB04938 | 1,668 | 1,423 | [
"DDInter1035",
"DDInter1353"
] | Lenalidomide | Ospemifene | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Major | 2 | [
[
[
1668,
25,
1423
]
],
[
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21,
28883
],
[
28883,
60,
1423
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],
[
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1668,
25,
1514
],
[
1514,
63,
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],
[
[
1668,
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129
],
[
1... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ospemifene"
]
],
[
[
"Lenalidomide",
"{u} (Compound) causes {v} (Side Effect)",
"Skin disorder"
],
[
"Skin disorder",
"{u} (Side Effect) is caused ... | Lenalidomide (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Ospemifene (Compound)
Lenalidomide may lead to a major life threatening interaction when taken with Human C1-esterase inhibitor and Human C1-esterase inhibitor may cause a moderate interaction that could exacerbate d... |
DB00539 | DB09098 | 11 | 98 | [
"DDInter1837",
"DDInter1700"
] | Toremifene | Somatrem | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
11,
24,
98
]
],
[
[
11,
25,
1612
],
[
1612,
62,
98
]
],
[
[
11,
24,
671
],
[
671,
24,
98
]
],
[
[
11,
24,
159
],
[
159,
63,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostemsavir... | Toremifene may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Somatrem
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause ... |
DB00501 | DB00637 | 752 | 1,557 | [
"DDInter380",
"DDInter128"
] | Cimetidine | Astemizole | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Major | 2 | [
[
[
752,
25,
1557
]
],
[
[
752,
24,
704
],
[
704,
1,
1557
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],
[
[
752,
25,
1568
],
[
1568,
64,
1557
]
],
[
[
752,
6,
21998
],
[
21998,
... | [
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Astemizole"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Astemizole (Compound)
Cimetidine may lead to a major life threatening interaction when taken with Pimozide and Pimozide may lead to a major life threatening interaction when taken with A... |
DB00994 | DB09135 | 361 | 1,211 | [
"DDInter1277",
"DDInter967"
] | Neomycin | Ioxilan | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
361,
25,
1211
]
],
[
[
361,
64,
1028
],
[
1028,
24,
1211
]
],
[
[
361,
23,
699
],
[
699,
24,
1211
]
],
[
[
361,
24,
242
],
[
242,
... | [
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Torasemide"
],
[
"Torasemide",
"{u} may caus... | Neomycin may lead to a major life threatening interaction when taken with Torasemide and Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Neomycin may cause a minor interaction that can limit clinical effects when taken with Nadolol and Nadolol may cause a moderate inte... |
DB00092 | DB10583 | 58 | 949 | [
"DDInter40",
"DDInter415"
] | Alefacept | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
58,
24,
949
]
],
[
[
58,
63,
550
],
[
550,
24,
949
]
],
[
[
58,
24,
589
],
[
589,
24,
949
]
],
[
[
58,
25,
1377
],
[
1377,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when tak... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Alefacept may cause a moderate interaction that could exacerb... |
DB00635 | DB06335 | 1,573 | 761 | [
"DDInter1515",
"DDInter1646"
] | Prednisone | Saxagliptin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1573,
24,
761
]
],
[
[
1573,
6,
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],
[
8374,
45,
761
]
],
[
[
1573,
21,
28722
],
[
28722,
60,
761
]
],
[
[
1573,
23,
307
],
[
307,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Prednisone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Prednisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Prednisone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Prednisone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil m... |
DB00982 | DB12035 | 1,517 | 943 | [
"DDInter991",
"DDInter1641"
] | Isotretinoin | Sarecycline | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Major | 2 | [
[
[
1517,
25,
943
]
],
[
[
1517,
24,
850
],
[
850,
24,
943
]
],
[
[
1517,
24,
1619
],
[
1619,
63,
943
]
],
[
[
1517,
63,
126
],
[
126,
... | [
[
[
"Isotretinoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sarecycline"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
],
[
... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB09118 | DB12500 | 1,580 | 283 | [
"DDInter1711",
"DDInter714"
] | Stiripentol | Fedratinib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1580,
24,
283
]
],
[
[
1580,
23,
466
],
[
466,
62,
283
]
],
[
[
1580,
24,
351
],
[
351,
23,
283
]
],
[
[
1580,
63,
1593
],
[
1593,
... | [
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Stiripentol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Stiripentol may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribo... |
DB00039 | DB11793 | 1,253 | 738 | [
"DDInter1380",
"DDInter1297"
] | Palifermin | Niraparib | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1253,
24,
738
]
],
[
[
1253,
24,
1213
],
[
1213,
24,
738
]
],
[
[
1253,
24,
1619
],
[
1619,
63,
738
]
],
[
[
1253,
63,
342
],
[
342,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib ... |
DB00322 | DB11817 | 141 | 1,259 | [
"DDInter742",
"DDInter165"
] | Floxuridine | Baricitinib | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
141,
25,
1259
]
],
[
[
141,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
141,
24,
949
],
[
949,
24,
1259
]
],
[
[
141,
24,
1129
],
[
1129,
... | [
[
[
"Floxuridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani tox... |
DB08899 | DB12674 | 129 | 975 | [
"DDInter649",
"DDInter1105"
] | Enzalutamide | Lurbinectedin | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
129,
25,
975
]
],
[
[
129,
25,
159
],
[
159,
63,
975
]
],
[
[
129,
24,
98
],
[
98,
24,
975
]
],
[
[
129,
63,
1532
],
[
1532,
24,... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
],
[
"Larotrectinib",... | Enzalutamide may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem m... |
DB01087 | DB06176 | 1,520 | 1,342 | [
"DDInter1520",
"DDInter1616"
] | Primaquine | Romidepsin | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1520,
24,
1342
]
],
[
[
1520,
62,
1247
],
[
1247,
23,
1342
]
],
[
[
1520,
63,
956
],
[
956,
24,
1342
]
],
[
[
1520,
24,
1616
],
[
1616... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Primaquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Primaquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin a... |
DB06210 | DB12141 | 72 | 971 | [
"DDInter631",
"DDInter817"
] | Eltrombopag | Gilteritinib | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
72,
24,
971
]
],
[
[
72,
24,
466
],
[
466,
62,
971
]
],
[
[
72,
24,
1097
],
[
1097,
24,
971
]
],
[
[
72,
63,
700
],
[
700,
24,
... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan and ... |
DB00934 | DB01142 | 413 | 1,264 | [
"DDInter1124",
"DDInter593"
] | Maprotiline | Doxepin | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
413,
24,
1264
]
],
[
[
413,
24,
401
],
[
401,
24,
1264
]
],
[
[
413,
63,
832
],
[
832,
24,
1264
]
],
[
[
413,
40,
11355
],
[
11355,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and... |
DB00489 | DB09135 | 17 | 1,211 | [
"DDInter1704",
"DDInter967"
] | Sotalol | Ioxilan | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
17,
24,
1211
]
],
[
[
17,
1,
88
],
[
88,
24,
1211
]
],
[
[
17,
24,
1013
],
[
1013,
63,
1211
]
],
[
[
17,
24,
512
],
[
512,
24,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Sotalol",
"{u} (Compound) resembles {v} (Compound)",
"Metoprolol"
],
[
"Metoprolol",
"{u} may cause a moderate interac... | Sotalol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction that coul... |
DB00013 | DB06603 | 1,255 | 39 | [
"DDInter1905",
"DDInter1387"
] | Urokinase | Panobinostat | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1255,
25,
39
]
],
[
[
1255,
24,
578
],
[
578,
63,
39
]
],
[
[
1255,
24,
383
],
[
383,
24,
39
]
],
[
[
1255,
25,
4
],
[
4,
24,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Ticagrelor... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate ... |
DB00563 | DB13874 | 663 | 1,501 | [
"DDInter1174",
"DDInter639"
] | Methotrexate | Enasidenib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
663,
24,
1501
]
],
[
[
663,
63,
1463
],
[
1463,
24,
1501
]
],
[
[
663,
24,
1619
],
[
1619,
24,
1501
]
],
[
[
663,
64,
1064
],
[
1064,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruc... |
DB00549 | DB00704 | 522 | 267 | [
"DDInter1955",
"DDInter1263"
] | Zafirlukast | Naltrexone | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
522,
24,
267
]
],
[
[
522,
63,
828
],
[
828,
25,
267
]
],
[
[
522,
21,
28787
],
[
28787,
60,
267
]
],
[
[
522,
24,
850
],
[
850,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone may lead to a major life threatening interaction when taken with Naltrexone
Zafirlukast (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Naltrexone (Compound)
Zafirluka... |
DB01156 | DB08903 | 593 | 996 | [
"DDInter252",
"DDInter170"
] | Bupropion | Bedaquiline | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
593,
24,
996
]
],
[
[
593,
63,
1376
],
[
1376,
1,
996
]
],
[
[
593,
24,
358
],
[
358,
40,
996
]
],
[
[
593,
6,
8374
],
[
8374,
4... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Bedaquiline (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Bedaquili... |
DB00019 | DB12839 | 1,257 | 919 | [
"DDInter1405",
"DDInter1411"
] | Pegfilgrastim | Pegvaliase | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and _trans_-cinnamic acid . Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients wit... | Moderate | 1 | [
[
[
1257,
24,
919
]
],
[
[
1257,
24,
934
],
[
934,
24,
919
]
],
[
[
1257,
63,
491
],
[
491,
24,
919
]
],
[
[
1257,
24,
934
],
[
934,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegvaliase"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegloticase"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Pegloticase and Pegloticase may cause a moderate interaction that could exacerbate diseases when taken with Pegvaliase
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon... |
DB00381 | DB01110 | 376 | 86 | [
"DDInter79",
"DDInter1209"
] | Amlodipine | Miconazole | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
376,
24,
86
]
],
[
[
376,
6,
8717
],
[
8717,
45,
86
]
],
[
[
376,
7,
8784
],
[
8784,
45,
86
]
],
[
[
376,
18,
2183
],
[
2183,
57... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",... | Amlodipine (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Miconazole (Compound)
Amlodipine (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is bound by Miconazole (Compound)
Amlodipine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Amlodipine (Comp... |
DB00598 | DB01097 | 1,523 | 1,377 | [
"DDInter1013",
"DDInter1033"
] | Labetalol | Leflunomide | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1523,
25,
1377
]
],
[
[
1523,
21,
29405
],
[
29405,
60,
1377
]
],
[
[
1523,
23,
126
],
[
126,
24,
1377
]
],
[
[
1523,
24,
959
],
[
959... | [
[
[
"Labetalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Labetalol",
"{u} (Compound) causes {v} (Side Effect)",
"Raised liver function tests"
],
[
"Raised liver function tests",
"{u} (... | Labetalol (Compound) causes Raised liver function tests (Side Effect) and Raised liver function tests (Side Effect) is caused by Leflunomide (Compound)
Labetalol may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate dis... |
DB01246 | DB14509 | 820 | 1,399 | [
"DDInter45",
"DDInter1081"
] | Alimemazine | Lithium carbonate | A phenothiazine derivative that is used as an antipruritic. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
820,
24,
1399
]
],
[
[
820,
63,
874
],
[
874,
23,
1399
]
],
[
[
820,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
820,
63,
506
],
[
506,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide ... |
DB00023 | DB06779 | 305 | 365 | [
"DDInter127",
"DDInter470"
] | Asparaginase Escherichia coli | Dalteparin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
305,
24,
365
]
],
[
[
305,
24,
954
],
[
954,
24,
365
]
],
[
[
305,
24,
1496
],
[
1496,
63,
365
]
],
[
[
305,
24,
1018
],
[
1018,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases w... |
DB00668 | DB00696 | 874 | 826 | [
"DDInter652",
"DDInter665"
] | Epinephrine | Ergotamine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Major | 2 | [
[
[
874,
25,
826
]
],
[
[
874,
64,
588
],
[
588,
1,
826
]
],
[
[
874,
64,
1131
],
[
1131,
40,
826
]
],
[
[
874,
25,
628
],
[
628,
1,... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ergotamine"
]
],
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylergometrine"
],
[
"Methylergometrin... | Epinephrine may lead to a major life threatening interaction when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergotamine (Compound)
Epinephrine may lead to a major life threatening interaction when taken with Methysergide and Methysergide (Compound) resembles Ergotamine (Compound)
Epinephrin... |
DB00081 | DB00476 | 273 | 109 | [
"DDInter1838",
"DDInter608"
] | Tositumomab | Duloxetine | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
273,
24,
109
]
],
[
[
273,
24,
758
],
[
758,
1,
109
]
],
[
[
273,
25,
1409
],
[
1409,
63,
109
]
],
[
[
273,
25,
702
],
[
702,
24... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
[
... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate disea... |
DB00816 | DB08881 | 1,674 | 868 | [
"DDInter1346",
"DDInter1925"
] | Orciprenaline | Vemurafenib | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1674,
25,
868
]
],
[
[
1674,
18,
16549
],
[
16549,
57,
868
]
],
[
[
1674,
7,
3222
],
[
3222,
57,
868
]
],
[
[
1674,
21,
29106
],
[
291... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Orciprenaline",
"{u} (Compound) downregulates {v} (Gene)",
"SLC2A6"
],
[
"SLC2A6",
"{u} (Gene) is downregulated by {v} (Com... | Orciprenaline (Compound) downregulates SLC2A6 (Gene) and SLC2A6 (Gene) is downregulated by Vemurafenib (Compound)
Orciprenaline (Compound) upregulates DUSP4 (Gene) and DUSP4 (Gene) is downregulated by Vemurafenib (Compound)
Orciprenaline (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Vem... |
DB00365 | DB01005 | 839 | 995 | [
"DDInter842",
"DDInter894"
] | Grepafloxacin | Hydroxyurea | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Minor | 0 | [
[
[
839,
23,
995
]
],
[
[
839,
23,
1238
],
[
1238,
24,
995
]
],
[
[
839,
23,
869
],
[
869,
63,
995
]
],
[
[
839,
24,
147
],
[
147,
2... | [
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pentostatin"
],
... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Pentostatin and Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Topotecan and To... |
DB14723 | DB14730 | 159 | 1,412 | [
"DDInter1026",
"DDInter264"
] | Larotrectinib | Calaspargase pegol | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
159,
24,
1412
]
],
[
[
159,
63,
792
],
[
792,
24,
1412
]
],
[
[
159,
64,
384
],
[
384,
24,
1412
]
],
[
[
159,
63,
1101
],
[
1101,
... | [
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
... | Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Larotrectinib may lead to a major life threatening interaction when taken with Idelalisib and Idela... |
DB00685 | DB13749 | 1,299 | 1,473 | [
"DDInter1887",
"DDInter1116"
] | Trovafloxacin | Magnesium gluconate | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
1299,
24,
1473
]
],
[
[
1299,
1,
872
],
[
872,
24,
1473
]
],
[
[
1299,
63,
544
],
[
544,
24,
1473
]
],
[
[
1299,
24,
853
],
[
853,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Gemifloxacin"
],
[
"Gemifloxacin",
"{u} ... | Trovafloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause ... |
DB00427 | DB00476 | 1,233 | 109 | [
"DDInter1879",
"DDInter608"
] | Triprolidine | Duloxetine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
1233,
24,
109
]
],
[
[
1233,
24,
758
],
[
758,
1,
109
]
],
[
[
1233,
63,
1302
],
[
1302,
1,
109
]
],
[
[
1233,
6,
12523
],
[
12523,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Duloxetine (... |
DB00804 | DB01085 | 1,507 | 562 | [
"DDInter543",
"DDInter1465"
] | Dicyclomine | Pilocarpine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Moderate | 1 | [
[
[
1507,
24,
562
]
],
[
[
1507,
6,
7992
],
[
7992,
45,
562
]
],
[
[
1507,
21,
28847
],
[
28847,
60,
562
]
],
[
[
1507,
24,
1192
],
[
1192... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pilocarpine"
]
],
[
[
"Dicyclomine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)"... | Dicyclomine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Pilocarpine (Compound)
Dicyclomine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Pilocarpine (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrro... |
DB08816 | DB11837 | 578 | 1,297 | [
"DDInter1802",
"DDInter1351"
] | Ticagrelor | Osilodrostat | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
578,
24,
1297
]
],
[
[
578,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
578,
63,
222
],
[
222,
23,
1297
]
],
[
[
578,
23,
907
],
[
907,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Ticagrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutrami... |
DB08913 | DB11767 | 1,186 | 1,583 | [
"DDInter1561",
"DDInter1643"
] | Radium Ra 223 dichloride | Sarilumab | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
1186,
24,
1583
]
],
[
[
1186,
63,
850
],
[
850,
24,
1583
]
],
[
[
1186,
24,
1362
],
[
1362,
24,
1583
]
],
[
[
1186,
24,
738
],
[
738,
... | [
[
[
"Radium Ra 223 dichloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Radium Ra 223 dichloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate d... |
DB00851 | DB08870 | 611 | 850 | [
"DDInter463",
"DDInter228"
] | Dacarbazine | Brentuximab vedotin | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
611,
24,
850
]
],
[
[
611,
24,
496
],
[
496,
63,
850
]
],
[
[
611,
63,
896
],
[
896,
24,
850
]
],
[
[
611,
24,
259
],
[
259,
24,... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vacc... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Dacarbazine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00207 | DB08870 | 1,570 | 850 | [
"DDInter157",
"DDInter228"
] | Azithromycin | Brentuximab vedotin | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1570,
24,
850
]
],
[
[
1570,
24,
267
],
[
267,
24,
850
]
],
[
[
1570,
63,
305
],
[
305,
24,
850
]
],
[
[
1570,
25,
1593
],
[
1593,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Asparagi... |
DB01041 | DB04574 | 770 | 177 | [
"DDInter1789",
"DDInter684"
] | Thalidomide | Estrone sulfate (topical) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Estrone 3-sulfate is a steroid sulfate that is the 3-sulfate of estrone. It has a role as a human metabolite and a mouse metabolite. It is a 17-oxo steroid and a steroid sulfate. It is functionally related to an estrone. It is a conjugate acid of an estrone 3-sulfate(1-). It derives from a hydride of an estrane. | Major | 2 | [
[
[
770,
25,
177
]
],
[
[
770,
64,
380
],
[
380,
1,
177
]
],
[
[
770,
25,
35
],
[
35,
1,
177
]
],
[
[
770,
6,
7950
],
[
7950,
45,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Estrone sulfate"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conjugated estrogens"
],
[
"Conjugat... | Thalidomide may lead to a major life threatening interaction when taken with Estrone sulfate
Thalidomide may lead to a major life threatening interaction when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Estrone sulfate (Compound)
Thalidomide may lead to a major life threatening interac... |
DB00289 | DB01218 | 847 | 1,493 | [
"DDInter132",
"DDInter852"
] | Atomoxetine | Halofantrine | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
847,
25,
1493
]
],
[
[
847,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
847,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
847,
40,
211
],
[
211,... | [
[
[
"Atomoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Hal... | Atomoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Atomoxetine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Atomoxetine (Compound) resembles Tolterodine (Compound) and Tolterodine may caus... |
DB00346 | DB00692 | 472 | 274 | [
"DDInter44",
"DDInter1448"
] | Alfuzosin | Phentolamine | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
472,
24,
274
]
],
[
[
472,
6,
5214
],
[
5214,
45,
274
]
],
[
[
472,
21,
29118
],
[
29118,
60,
274
]
],
[
[
472,
24,
530
],
[
530,
... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)",... | Alfuzosin (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Phentolamine (Compound)
Alfuzosin (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and... |
DB00543 | DB01067 | 87 | 959 | [
"DDInter82",
"DDInter826"
] | Amoxapine | Glipizide | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
87,
24,
959
]
],
[
[
87,
63,
245
],
[
245,
40,
959
]
],
[
[
87,
24,
1411
],
[
1411,
1,
959
]
],
[
[
87,
21,
28698
],
[
28698,
60... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB01255 | DB06767 | 633 | 732 | [
"DDInter1078",
"DDInter80"
] | Lisdexamfetamine | Ammonium chloride | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions. | Moderate | 1 | [
[
[
633,
24,
732
]
],
[
[
633,
63,
1264
],
[
1264,
23,
732
]
],
[
[
633,
24,
22
],
[
22,
23,
732
]
],
[
[
633,
40,
1529
],
[
1529,
2... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ammonium chloride"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"... | Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine ... |
DB00280 | DB06176 | 494 | 1,342 | [
"DDInter575",
"DDInter1616"
] | Disopyramide | Romidepsin | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
494,
25,
1342
]
],
[
[
494,
23,
112
],
[
112,
23,
1342
]
],
[
[
494,
25,
485
],
[
485,
24,
1342
]
],
[
[
494,
25,
1616
],
[
1616,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Disopyramide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Disopyramide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine ma... |
DB00202 | DB00863 | 190 | 1,194 | [
"DDInter1716",
"DDInter1568"
] | Succinylcholine | Ranitidine | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Minor | 0 | [
[
[
190,
23,
1194
]
],
[
[
190,
21,
31998
],
[
31998,
60,
1194
]
],
[
[
190,
24,
1031
],
[
1031,
24,
1194
]
],
[
[
190,
24,
1011
],
[
1011... | [
[
[
"Succinylcholine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
]
],
[
[
"Succinylcholine",
"{u} (Compound) causes {v} (Side Effect)",
"Porphyrin metabolism disorder"
],
[
"Porphyrin metabo... | Succinylcholine (Compound) causes Porphyrin metabolism disorder (Side Effect) and Porphyrin metabolism disorder (Side Effect) is caused by Ranitidine (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction ... |
DB08880 | DB12674 | 1,510 | 975 | [
"DDInter1771",
"DDInter1105"
] | Teriflunomide | Lurbinectedin | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
1510,
25,
975
]
],
[
[
1510,
64,
1488
],
[
1488,
24,
975
]
],
[
[
1510,
25,
1613
],
[
1613,
24,
975
]
],
[
[
1510,
25,
159
],
[
159,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabine"
],
[
"Fludarabine",
... | Teriflunomide may lead to a major life threatening interaction when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Teriflunomide may lead to a major life threatening interaction when taken with Peginterferon beta-1a and Peginterferon ... |
DB00477 | DB01041 | 216 | 770 | [
"DDInter363",
"DDInter1789"
] | Chlorpromazine | Thalidomide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
216,
24,
770
]
],
[
[
216,
6,
6365
],
[
6365,
45,
770
]
],
[
[
216,
7,
7669
],
[
7669,
46,
770
]
],
[
[
216,
21,
28789
],
[
28789,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Co... | Chlorpromazine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Chlorpromazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Chlorpromazine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is ... |
DB00554 | DB09268 | 1,027 | 1,662 | [
"DDInter1478",
"DDInter1464"
] | Piroxicam | Picosulfuric acid | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1027,
24,
1662
]
],
[
[
1027,
23,
16
],
[
16,
23,
1662
]
],
[
[
1027,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
1027,
25,
1618
],
[
1618,
... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Piroxicam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
],
... | Piroxicam may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruca... |
DB01233 | DB06700 | 1,311 | 643 | [
"DDInter1197",
"DDInter511"
] | Metoclopramide | Desvenlafaxine | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
1311,
24,
643
]
],
[
[
1311,
63,
1100
],
[
1100,
1,
643
]
],
[
[
1311,
21,
29597
],
[
29597,
60,
643
]
],
[
[
1311,
24,
1383
],
[
1383... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Metoclopramide (Compound) causes Feeling jittery (Side Effect) and Feeling jittery (Side Effect) is caused by Desvenlafaxine (Compound)
Metoclopramide... |
DB00687 | DB10276 | 870 | 1,624 | [
"DDInter747",
"DDInter1623"
] | Fludrocortisone | Rotavirus vaccine | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
870,
25,
1624
]
],
[
[
870,
25,
375
],
[
375,
25,
1624
]
],
[
[
870,
63,
58
],
[
58,
25,
1624
]
],
[
[
870,
1,
1220
],
[
1220,
2... | [
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
],
[
"... | Fludrocortisone may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may lead to a major life threatening interaction when taken with Rotavirus vaccine
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alef... |
DB00342 | DB01072 | 1,181 | 915 | [
"DDInter1770",
"DDInter129"
] | Terfenadine | Atazanavir | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Major | 2 | [
[
[
1181,
25,
915
]
],
[
[
1181,
25,
1327
],
[
1327,
1,
915
]
],
[
[
1181,
24,
1374
],
[
1374,
62,
915
]
],
[
[
1181,
23,
1387
],
[
1387,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atazanavir"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavir",
"{u}... | Terfenadine may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical ... |
DB00836 | DB01001 | 543 | 688 | [
"DDInter1088",
"DDInter1632"
] | Loperamide | Salbutamol | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
543,
24,
688
]
],
[
[
543,
6,
8374
],
[
8374,
45,
688
]
],
[
[
543,
21,
28714
],
[
28714,
60,
688
]
],
[
[
543,
24,
112
],
[
112,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Loperamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Loperamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Salbutamol (Compound)
Loperamide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Salbutamol (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Met... |
DB00353 | DB00877 | 588 | 629 | [
"DDInter1187",
"DDInter1678"
] | Methylergometrine | Sirolimus | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
588,
24,
629
]
],
[
[
588,
6,
8374
],
[
8374,
45,
629
]
],
[
[
588,
7,
19625
],
[
19625,
46,
629
]
],
[
[
588,
18,
4893
],
[
4893,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Methylergometrine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Methylergometrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Methylergometrine (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Sirolimus (Compound)
Methylergometrine (Compound) downregulates S100A13 (Gene) and S100A13 (Gene) is upregulated by Sirolimus (Co... |
DB00690 | DB00902 | 1,216 | 104 | [
"DDInter762",
"DDInter1168"
] | Flurazepam | Methdilazine | A benzodiazepine derivative used mainly as a hypnotic. | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1216,
24,
104
]
],
[
[
1216,
63,
13
],
[
13,
24,
104
]
],
[
[
1216,
24,
820
],
[
820,
1,
104
]
],
[
[
1216,
24,
537
],
[
537,
40... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB01030 | DB06688 | 869 | 1,430 | [
"DDInter1835",
"DDInter1677"
] | Topotecan | Sipuleucel-T | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
869,
24,
1430
]
],
[
[
869,
63,
51
],
[
51,
24,
1430
]
],
[
[
869,
25,
676
],
[
676,
63,
1430
]
],
[
[
869,
24,
1531
],
[
1531,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Topotecan may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib ma... |
DB08881 | DB11575 | 868 | 1,676 | [
"DDInter1925",
"DDInter841"
] | Vemurafenib | Grazoprevir | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Moderate | 1 | [
[
[
868,
24,
1676
]
],
[
[
868,
63,
723
],
[
723,
24,
1676
]
],
[
[
868,
64,
1151
],
[
1151,
24,
1676
]
],
[
[
868,
25,
351
],
[
351,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Grazoprevir"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Vemurafenib may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause... |
DB08896 | DB11932 | 292 | 327 | [
"DDInter1576",
"DDInter3"
] | Regorafenib | Abametapir (topical) | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
292,
24,
327
]
],
[
[
292,
25,
283
],
[
283,
63,
327
]
],
[
[
292,
63,
613
],
[
613,
24,
327
]
],
[
[
292,
40,
79
],
[
79,
24,
... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratin... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Regorafenib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Regorafenib may cause a... |
DB00047 | DB00367 | 176 | 566 | [
"DDInter932",
"DDInter1061"
] | Insulin glargine | Levonorgestrel | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Moderate | 1 | [
[
[
176,
24,
566
]
],
[
[
176,
24,
1336
],
[
1336,
40,
566
]
],
[
[
176,
24,
1197
],
[
1197,
1,
566
]
],
[
[
176,
24,
1130
],
[
1130,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestre... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Etonogestrel and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) rese... |
DB00641 | DB01076 | 467 | 700 | [
"DDInter1675",
"DDInter133"
] | Simvastatin | Atorvastatin | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
467,
24,
700
]
],
[
[
467,
25,
1080
],
[
1080,
1,
700
]
],
[
[
467,
24,
788
],
[
788,
1,
700
]
],
[
[
467,
5,
11576
],
[
11576,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Coniva... | Simvastatin may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Atorvastatin (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Simva... |
DB01114 | DB01618 | 272 | 776 | [
"DDInter362",
"DDInter1239"
] | Chlorpheniramine | Molindone | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
272,
24,
776
]
],
[
[
272,
21,
28800
],
[
28800,
60,
776
]
],
[
[
272,
74,
100
],
[
100,
24,
776
]
],
[
[
272,
63,
1442
],
[
1442,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) causes {v} (Side Effect)",
"Dyskinesia"
],
[
"Dyskinesia",
"{u} (Side Ef... | Chlorpheniramine (Compound) causes Dyskinesia (Side Effect) and Dyskinesia (Side Effect) is caused by Molindone (Compound)
Chlorpheniramine (Compound) resembles Brompheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Bromphenira... |
DB01067 | DB04398 | 959 | 193 | [
"DDInter826",
"DDInter1015"
] | Glipizide | Lactic acid | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as ... | Minor | 0 | [
[
[
959,
23,
193
]
],
[
[
959,
40,
1411
],
[
1411,
23,
193
]
],
[
[
959,
24,
22
],
[
22,
24,
193
]
],
[
[
959,
63,
1479
],
[
1479,
2... | [
[
[
"Glipizide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lactic acid"
]
],
[
[
"Glipizide",
"{u} (Compound) resembles {v} (Compound)",
"Tolbutamide"
],
[
"Tolbutamide",
"{u} may cause a minor in... | Glipizide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Lactic acid
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a moderate interaction that could ex... |
DB01190 | DB01211 | 568 | 609 | [
"DDInter398",
"DDInter393"
] | Clindamycin | Clarithromycin | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
568,
24,
609
]
],
[
[
568,
6,
8374
],
[
8374,
45,
609
]
],
[
[
568,
21,
28803
],
[
28803,
60,
609
]
],
[
[
568,
24,
34
],
[
34,
... | [
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Clindamycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Clindamycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Clindamycin (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Clarithromycin (Compound)
Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavi... |
DB01218 | DB06402 | 1,493 | 1,079 | [
"DDInter852",
"DDInter1756"
] | Halofantrine | Telavancin | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Major | 2 | [
[
[
1493,
25,
1079
]
],
[
[
1493,
21,
28680
],
[
28680,
60,
1079
]
],
[
[
1493,
62,
112
],
[
112,
23,
1079
]
],
[
[
1493,
24,
657
],
[
657... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
]
],
[
[
"Halofantrine",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (Compound)"... | Halofantrine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telavancin (Compound)
Halofantrine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
... |
DB00494 | DB00682 | 1,533 | 126 | [
"DDInter646",
"DDInter1951"
] | Entacapone | Warfarin | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
1533,
23,
126
]
],
[
[
1533,
24,
1376
],
[
1376,
40,
126
]
],
[
[
1533,
25,
1053
],
[
1053,
62,
126
]
],
[
[
1533,
40,
1062
],
[
1062,... | [
[
[
"Entacapone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Entacapone may lead to a major life threatening interaction when taken with Procarbazine and Procarbazine may cause a minor interaction that can limit c... |
DB00197 | DB14731 | 1,324 | 1,518 | [
"DDInter1881",
"DDInter1741"
] | Troglitazone | Tagraxofusp | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
1324,
24,
1518
]
],
[
[
1324,
63,
176
],
[
176,
24,
1518
]
],
[
[
1324,
24,
1130
],
[
1130,
24,
1518
]
],
[
[
1324,
24,
242
],
[
242,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Piog... |
DB00330 | DB00641 | 238 | 467 | [
"DDInter689",
"DDInter1675"
] | Ethambutol | Simvastatin | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
238,
24,
467
]
],
[
[
238,
21,
28810
],
[
28810,
60,
467
]
],
[
[
238,
63,
367
],
[
367,
24,
467
]
],
[
[
238,
24,
134
],
[
134,
... | [
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Ethambutol",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"... | Ethambutol (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Simvastatin (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that coul... |
DB00816 | DB14509 | 1,674 | 1,399 | [
"DDInter1346",
"DDInter1081"
] | Orciprenaline | Lithium carbonate | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1674,
24,
1399
]
],
[
[
1674,
63,
874
],
[
874,
23,
1399
]
],
[
[
1674,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
1674,
63,
1010
],
[
1010... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Semaglut... |
DB00398 | DB12267 | 79 | 1,476 | [
"DDInter1702",
"DDInter233"
] | Sorafenib | Brigatinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
79,
24,
1476
]
],
[
[
79,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
79,
23,
1135
],
[
1135,
23,
1476
]
],
[
[
79,
24,
629
],
[
629,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol m... |
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