drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB09039 | DB11799 | 1,670 | 627 | [
"DDInter629",
"DDInter205"
] | Eliglustat | Bictegravir | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Moderate | 1 | [
[
[
1670,
24,
627
]
],
[
[
1670,
63,
578
],
[
578,
24,
627
]
],
[
[
1670,
64,
600
],
[
600,
24,
627
]
],
[
[
1670,
25,
741
],
[
741,
... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Eliglustat may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cau... |
DB00970 | DB10315 | 0 | 1,137 | [
"DDInter466",
"DDInter1127"
] | Dactinomycin | Measles virus vaccine live attenuated | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
0,
25,
1137
]
],
[
[
0,
64,
581
],
[
581,
25,
1137
]
],
[
[
0,
24,
384
],
[
384,
25,
1137
]
],
[
[
0,
63,
1184
],
[
1184,
25,
... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Dactinomycin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idela... |
DB00526 | DB11817 | 1,555 | 1,259 | [
"DDInter1355",
"DDInter165"
] | Oxaliplatin | Baricitinib | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1555,
25,
1259
]
],
[
[
1555,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
1555,
24,
1274
],
[
1274,
24,
1259
]
],
[
[
1555,
63,
598
],
[
598... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurb... |
DB00333 | DB00889 | 576 | 1,133 | [
"DDInter1166",
"DDInter840"
] | Methadone | Granisetron | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
576,
25,
1133
]
],
[
[
576,
24,
19
],
[
19,
40,
1133
]
],
[
[
576,
24,
85
],
[
85,
1,
1133
]
],
[
[
576,
6,
8374
],
[
8374,
45,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamin... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Compound)
Me... |
DB00047 | DB01278 | 176 | 1,021 | [
"DDInter932",
"DDInter1506"
] | Insulin glargine | Pramlintide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
176,
24,
1021
]
],
[
[
176,
23,
1103
],
[
1103,
23,
1021
]
],
[
[
176,
24,
1560
],
[
1560,
24,
1021
]
],
[
[
176,
25,
839
],
[
839,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
... | Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Pramlintide
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase... |
DB00533 | DB13074 | 1,416 | 877 | [
"DDInter1613",
"DDInter1110"
] | Rofecoxib | Macimorelin | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
1416,
24,
877
]
],
[
[
1416,
24,
1479
],
[
1479,
24,
877
]
],
[
[
1416,
63,
251
],
[
251,
24,
877
]
],
[
[
1416,
24,
477
],
[
477,
... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Be... |
DB00023 | DB00586 | 305 | 1,512 | [
"DDInter127",
"DDInter537"
] | Asparaginase Escherichia coli | Diclofenac | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
305,
24,
1512
]
],
[
[
305,
24,
1263
],
[
1263,
63,
1512
]
],
[
[
305,
24,
1622
],
[
1622,
24,
1512
]
],
[
[
305,
25,
976
],
[
976,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases w... |
DB00374 | DB00880 | 1,061 | 359 | [
"DDInter1852",
"DDInter360"
] | Treprostinil | Chlorothiazide | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
1061,
24,
359
]
],
[
[
1061,
24,
1577
],
[
1577,
1,
359
]
],
[
[
1061,
21,
28784
],
[
28784,
60,
359
]
],
[
[
1061,
24,
126
],
[
126,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Treprostinil (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Chlorothiazide (Compound)
Tr... |
DB00085 | DB01592 | 639 | 1,596 | [
"DDInter1384",
"DDInter975"
] | Pancrelipase | Iron | Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010. For further informa... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
639,
24,
1596
]
],
[
[
639,
24,
1384
],
[
1384,
63,
1596
]
],
[
[
639,
24,
1117
],
[
1117,
24,
1596
]
],
[
[
639,
24,
1384
],
[
1384,
... | [
[
[
"Pancrelipase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Pancrelipase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
],
[
... | Pancrelipase may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Iron
Pancrelipase may cause a moderate interaction that could exacerbate diseases when taken with Sodium bicarbonate and ... |
DB05239 | DB08912 | 866 | 1,040 | [
"DDInter425",
"DDInter462"
] | Cobimetinib | Dabrafenib | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Major | 2 | [
[
[
866,
25,
1040
]
],
[
[
866,
63,
1101
],
[
1101,
23,
1040
]
],
[
[
866,
63,
478
],
[
478,
24,
1040
]
],
[
[
866,
24,
1478
],
[
1478,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dabrafenib"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dabrafenib
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotin... |
DB00106 | DB01087 | 618 | 1,520 | [
"DDInter4",
"DDInter1520"
] | Abarelix | Primaquine | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
618,
24,
1520
]
],
[
[
618,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
618,
23,
112
],
[
112,
23,
1520
]
],
[
[
618,
24,
479
],
[
479,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronid... |
DB11915 | DB11967 | 1,293 | 710 | [
"DDInter1909",
"DDInter210"
] | Valbenazine | Binimetinib | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1293,
24,
710
]
],
[
[
1293,
64,
1593
],
[
1593,
24,
710
]
],
[
[
1293,
63,
1557
],
[
1557,
24,
710
]
],
[
[
1293,
24,
1619
],
[
1619,... | [
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Valbenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizoti... | Valbenazine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may cau... |
DB09020 | DB11642 | 28 | 938 | [
"DDInter212",
"DDInter1480"
] | Bisacodyl | Pitolisant | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
28,
24,
938
]
],
[
[
28,
63,
600
],
[
600,
24,
938
]
],
[
[
28,
24,
1228
],
[
1228,
24,
938
]
],
[
[
28,
24,
927
],
[
927,
63,
... | [
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib and Lenvat... |
DB00734 | DB06788 | 1,664 | 1,616 | [
"DDInter1605",
"DDInter864"
] | Risperidone | Histrelin | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1664,
24,
1616
]
],
[
[
1664,
23,
112
],
[
112,
23,
1616
]
],
[
[
1664,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
1664,
63,
1179
],
[
1179... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Risperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Rom... |
DB00270 | DB00959 | 1,428 | 1,486 | [
"DDInter993",
"DDInter1191"
] | Isradipine | Methylprednisolone | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
1428,
24,
1486
]
],
[
[
1428,
24,
175
],
[
175,
40,
1486
]
],
[
[
1428,
24,
167
],
[
167,
1,
1486
]
],
[
[
1428,
6,
8374
],
[
8374,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB01110 | DB06605 | 86 | 1,409 | [
"DDInter1209",
"DDInter108"
] | Miconazole | Apixaban | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
86,
24,
1409
]
],
[
[
86,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
86,
21,
29061
],
[
29061,
60,
1409
]
],
[
[
86,
62,
307
],
[
307,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",... | Miconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Miconazole (Compound) causes Gamma-glutamyltransferase increased (Side Effect) and Gamma-glutamyltransferase increased (Side Effect) is caused by Apixaban (Compound)
Miconazole may cause a minor interaction that can limit clin... |
DB02701 | DB09043 | 1,632 | 135 | [
"DDInter1289",
"DDInter36"
] | Nicotinamide | Albiglutide | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1632,
24,
135
]
],
[
[
1632,
63,
1647
],
[
1647,
23,
135
]
],
[
[
1632,
63,
176
],
[
176,
24,
135
]
],
[
[
1632,
24,
1412
],
[
1412,
... | [
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and I... |
DB01377 | DB06799 | 1,283 | 212 | [
"DDInter1119",
"DDInter1169"
] | Magnesium oxide | Methenamine | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine). | Moderate | 1 | [
[
[
1283,
24,
212
]
],
[
[
1283,
24,
286
],
[
286,
63,
212
]
],
[
[
1283,
24,
286
],
[
286,
24,
460
],
[
460,
63,
212
]
],
[
[
1283,
... | [
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methenamine"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydrox... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Methenamine
Magnesium oxide may cause a moderate interaction that could exacerbate diseases when tak... |
DB00701 | DB01377 | 1,091 | 1,283 | [
"DDInter90",
"DDInter1119"
] | Amprenavir | Magnesium oxide | Amprenavir is a protease inhibitor used to treat HIV infection. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1091,
24,
1283
]
],
[
[
1091,
24,
167
],
[
167,
23,
1283
]
],
[
[
1091,
63,
1573
],
[
1573,
23,
1283
]
],
[
[
1091,
25,
1468
],
[
1468... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone... |
DB01268 | DB06663 | 1,151 | 1,154 | [
"DDInter1731",
"DDInter1398"
] | Sunitinib | Pasireotide | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1151,
25,
1154
]
],
[
[
1151,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1151,
62,
112
],
[
112,
23,
1154
]
],
[
[
1151,
63,
88
],
[
88,
... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Sunitinib",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused by ... | Sunitinib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Sunitinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00860 | DB06710 | 891 | 1,546 | [
"DDInter1513",
"DDInter1193"
] | Prednisolone | Methyltestosterone | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
891,
35,
1546
]
],
[
[
891,
40,
1581
],
[
1581,
1,
1546
]
],
[
[
891,
63,
312
],
[
312,
1,
1546
]
],
[
[
891,
24,
155
],
[
155,
... | [
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Testolactone"
]... | Prednisolone (Compound) resembles Methyltestosterone (Compound) and
Prednisolone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Methyltestosterone (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone (Compou... |
DB00475 | DB09481 | 1,119 | 460 | [
"DDInter355",
"DDInter1113"
] | Chlordiazepoxide | Magnesium carbonate | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1119,
23,
460
]
],
[
[
1119,
24,
401
],
[
401,
23,
460
]
],
[
[
1119,
40,
1382
],
[
1382,
23,
460
]
],
[
[
1119,
1,
523
],
[
523,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prometha... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Chlordiazepoxide (Compound) resembles Midazolam (Compound) and Midazolam may cause a minor inte... |
DB00635 | DB01320 | 1,573 | 651 | [
"DDInter1515",
"DDInter783"
] | Prednisone | Fosphenytoin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1573,
24,
651
]
],
[
[
1573,
23,
307
],
[
307,
1,
651
]
],
[
[
1573,
63,
362
],
[
362,
1,
651
]
],
[
[
1573,
24,
998
],
[
998,
1... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Pr... |
DB11932 | DB12500 | 327 | 283 | [
"DDInter3",
"DDInter714"
] | Abametapir (topical) | Fedratinib | Abametapir is a member of bipyridines. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
327,
24,
283
]
],
[
[
327,
63,
351
],
[
351,
23,
283
]
],
[
[
327,
63,
1419
],
[
1419,
24,
283
]
],
[
[
327,
24,
971
],
[
971,
2... | [
[
[
"Abametapir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Abametapir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Abametapir may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Abametapir may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Abametapir m... |
DB01254 | DB11730 | 1,213 | 351 | [
"DDInter484",
"DDInter1588"
] | Dasatinib | Ribociclib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1213,
25,
351
]
],
[
[
1213,
23,
271
],
[
271,
23,
351
]
],
[
[
1213,
62,
1247
],
[
1247,
23,
351
]
],
[
[
1213,
63,
222
],
[
222,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Dasatinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamet... |
DB00365 | DB01278 | 839 | 1,021 | [
"DDInter842",
"DDInter1506"
] | Grepafloxacin | Pramlintide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
839,
24,
1021
]
],
[
[
839,
25,
891
],
[
891,
24,
1021
]
],
[
[
839,
25,
1019
],
[
1019,
63,
1021
]
],
[
[
839,
24,
127
],
[
127,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisolone"
],
[
"P... | Grepafloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Grepafloxacin may lead to a major life threatening interaction when taken with Deflazacort and Deflazacort may cause a ... |
DB00295 | DB01136 | 475 | 772 | [
"DDInter1244",
"DDInter305"
] | Morphine | Carvedilol | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
475,
24,
772
]
],
[
[
475,
6,
12523
],
[
12523,
45,
772
]
],
[
[
475,
21,
28997
],
[
28997,
60,
772
]
],
[
[
475,
24,
1054
],
[
1054,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Morphine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Morphine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Carvedilol (Compound)
Morphine (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Carvedilol (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Kao... |
DB01115 | DB12500 | 336 | 283 | [
"DDInter1291",
"DDInter714"
] | Nifedipine | Fedratinib | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
336,
24,
283
]
],
[
[
336,
23,
466
],
[
466,
62,
283
]
],
[
[
336,
24,
351
],
[
351,
23,
283
]
],
[
[
336,
63,
1419
],
[
1419,
2... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Nifedipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Nifedipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboci... |
DB04868 | DB06414 | 478 | 655 | [
"DDInter1293",
"DDInter703"
] | Nilotinib | Etravirine | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
478,
24,
655
]
],
[
[
478,
25,
786
],
[
786,
40,
655
]
],
[
[
478,
6,
4973
],
[
4973,
45,
655
]
],
[
[
478,
21,
28740
],
[
28740,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilpivirine"
],
[
"Rilpivirine... | Nilotinib may lead to a major life threatening interaction when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Nilotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Nilotinib (Compound) causes Disturbance in attention (Side Effect) and Disturbance ... |
DB00705 | DB08865 | 441 | 1,593 | [
"DDInter496",
"DDInter448"
] | Delavirdine | Crizotinib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
441,
25,
1593
]
],
[
[
441,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
441,
21,
29093
],
[
29093,
60,
1593
]
],
[
[
441,
25,
283
],
[
283,
... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Delavirdine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizo... | Delavirdine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Delavirdine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Delavirdine may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause... |
DB01162 | DB09038 | 195 | 1,450 | [
"DDInter1767",
"DDInter636"
] | Terazosin | Empagliflozin | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
195,
24,
1450
]
],
[
[
195,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
195,
1,
1433
],
[
1433,
24,
1450
]
],
[
[
195,
24,
885
],
[
885,
... | [
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[... | Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Terazosin (Compound) resembles Doxazosin (Compound) and Doxazosin may cause a moderate interaction that co... |
DB00026 | DB13985 | 1,184 | 546 | [
"DDInter94",
"DDInter1108"
] | Anakinra | Lutetium Lu 177 dotatate | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
1184,
24,
546
]
],
[
[
1184,
24,
66
],
[
66,
24,
546
]
],
[
[
1184,
64,
1057
],
[
1057,
25,
546
]
],
[
[
1184,
25,
1377
],
[
1377,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
]... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Anakinra may lead to a major life threatening interaction when taken with Etanercept and Etanercept ... |
DB00023 | DB01041 | 305 | 770 | [
"DDInter127",
"DDInter1789"
] | Asparaginase Escherichia coli | Thalidomide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
305,
25,
770
]
],
[
[
305,
24,
1668
],
[
1668,
1,
770
]
],
[
[
305,
24,
609
],
[
609,
63,
770
]
],
[
[
305,
24,
876
],
[
876,
24... | [
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Len... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarith... |
DB00380 | DB10276 | 145 | 1,624 | [
"DDInter522",
"DDInter1623"
] | Dexrazoxane | Rotavirus vaccine | An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug ... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
145,
25,
1624
]
],
[
[
145,
24,
713
],
[
713,
25,
1624
]
],
[
[
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3930
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[
3930,
45,
51
],
[
51,
25,
1624
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],
[
[
145,
2... | [
[
[
"Dexrazoxane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Dexrazoxane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
],
[
... | Dexrazoxane may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may lead to a major life threatening interaction when taken with Rotavirus vaccine
Dexrazoxane (Compound) binds TOP2B (Gene) and TOP2B (Gene) is bound by Daunorubicin (Compound) and Daunor... |
DB00261 | DB00334 | 702 | 867 | [
"DDInter93",
"DDInter1326"
] | Anagrelide | Olanzapine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Moderate | 1 | [
[
[
702,
24,
867
]
],
[
[
702,
25,
695
],
[
695,
40,
867
]
],
[
[
702,
6,
7950
],
[
7950,
45,
867
]
],
[
[
702,
23,
112
],
[
112,
62... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olanzapine"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Clozapine",... | Anagrelide may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Olanzapine (Compound)
Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Olanzapine (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken... |
DB00987 | DB10315 | 1,224 | 1,137 | [
"DDInter460",
"DDInter1127"
] | Cytarabine | Measles virus vaccine live attenuated | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1224,
25,
1137
]
],
[
[
1224,
64,
581
],
[
581,
25,
1137
]
],
[
[
1224,
24,
384
],
[
384,
25,
1137
]
],
[
[
1224,
63,
1184
],
[
1184,
... | [
[
[
"Cytarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Cytarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Cytarabine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB00399 | DB01050 | 963 | 848 | [
"DDInter1968",
"DDInter900"
] | Zoledronic acid | Ibuprofen | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
963,
24,
848
]
],
[
[
963,
6,
10417
],
[
10417,
45,
848
]
],
[
[
963,
21,
28773
],
[
28773,
60,
848
]
],
[
[
963,
24,
91
],
[
91,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Zoledronic acid",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Comp... | Zoledronic acid (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Ibuprofen (Compound)
Zoledronic acid (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Zoledronic acid may cause a moderate interaction that could exacerbate diseases when tak... |
DB00872 | DB11760 | 1,080 | 119 | [
"DDInter438",
"DDInter1742"
] | Conivaptan | Talazoparib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
1080,
24,
119
]
],
[
[
1080,
25,
985
],
[
985,
24,
119
]
],
[
[
1080,
25,
1406
],
[
1406,
63,
119
]
],
[
[
1080,
24,
292
],
[
292,
... | [
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
],
[
"Osimerti... | Conivaptan may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Conivaptan may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a moderate int... |
DB01100 | DB09076 | 1,568 | 1,116 | [
"DDInter1470",
"DDInter1899"
] | Pimozide | Umeclidinium | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1568,
24,
1116
]
],
[
[
1568,
24,
849
],
[
849,
24,
1116
]
],
[
[
1568,
64,
401
],
[
401,
24,
1116
]
],
[
[
1568,
63,
1442
],
[
1442,
... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Pimozide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may caus... |
DB01203 | DB01575 | 699 | 1,054 | [
"DDInter1255",
"DDInter1005"
] | Nadolol | Kaolin | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Minor | 0 | [
[
[
699,
23,
1054
]
],
[
[
699,
40,
729
],
[
729,
23,
1054
]
],
[
[
699,
24,
407
],
[
407,
63,
1054
]
],
[
[
699,
63,
85
],
[
85,
24... | [
[
[
"Nadolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Kaolin"
]
],
[
[
"Nadolol",
"{u} (Compound) resembles {v} (Compound)",
"Penbutolol"
],
[
"Penbutolol",
"{u} may cause a minor interaction t... | Nadolol (Compound) resembles Penbutolol (Compound) and Penbutolol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases w... |
DB00745 | DB04845 | 307 | 309 | [
"DDInter1236",
"DDInter1001"
] | Modafinil | Ixabepilone | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Minor | 0 | [
[
[
307,
23,
309
]
],
[
[
307,
6,
8374
],
[
8374,
45,
309
]
],
[
[
307,
21,
28987
],
[
28987,
60,
309
]
],
[
[
307,
62,
1419
],
[
1419,
... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ixabepilone"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Modafinil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Modafinil (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Modafinil may cause a minor interaction that can limit clinical effects when taken with Imatinib and Imatinib may ca... |
DB01222 | DB08822 | 617 | 911 | [
"DDInter246",
"DDInter156"
] | Budesonide | Azilsartan medoxomil | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
617,
24,
911
]
],
[
[
617,
63,
217
],
[
217,
1,
911
]
],
[
[
617,
21,
28880
],
[
28880,
60,
911
]
],
[
[
617,
40,
1220
],
[
1220,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
]... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Budesonide (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Azilsartan medoxomil (Compound)
Budesonide (Compound) ... |
DB06688 | DB12240 | 1,430 | 110 | [
"DDInter1677",
"DDInter1485"
] | Sipuleucel-T | Polatuzumab vedotin | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1430,
24,
110
]
],
[
[
1430,
63,
1419
],
[
1419,
24,
110
]
],
[
[
1430,
24,
951
],
[
951,
24,
110
]
],
[
[
1430,
24,
1619
],
[
1619,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib ... |
DB06237 | DB11730 | 438 | 351 | [
"DDInter141",
"DDInter1588"
] | Avanafil | Ribociclib | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
438,
25,
351
]
],
[
[
438,
25,
283
],
[
283,
62,
351
]
],
[
[
438,
24,
98
],
[
98,
24,
351
]
],
[
[
438,
63,
1324
],
[
1324,
24,... | [
[
[
"Avanafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Avanafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{u} may c... | Avanafil may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Avanafil may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate... |
DB00496 | DB01110 | 194 | 86 | [
"DDInter480",
"DDInter1209"
] | Darifenacin | Miconazole | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
194,
24,
86
]
],
[
[
194,
6,
8374
],
[
8374,
45,
86
]
],
[
[
194,
21,
29122
],
[
29122,
60,
86
]
],
[
[
194,
40,
1413
],
[
1413,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Darifenacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Darifenacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound)
Darifenacin (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Darifenacin (Compound) resembles Fexofenadine (Compound) and Fexofenadine may cause a ... |
DB01149 | DB08912 | 851 | 1,040 | [
"DDInter1274",
"DDInter462"
] | Nefazodone | Dabrafenib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
851,
24,
1040
]
],
[
[
851,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
851,
18,
4729
],
[
4729,
57,
1040
]
],
[
[
851,
21,
28900
],
[
28900,... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Nefazodone (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dabrafenib (Compound)
Nefazodone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib... |
DB00831 | DB08875 | 1,178 | 1,618 | [
"DDInter1866",
"DDInter262"
] | Trifluoperazine | Cabozantinib | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1178,
25,
1618
]
],
[
[
1178,
23,
112
],
[
112,
23,
1618
]
],
[
[
1178,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
1178,
24,
480
],
[
480,
... | [
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Picosul... |
DB00726 | DB01114 | 1,164 | 272 | [
"DDInter1876",
"DDInter362"
] | Trimipramine | Chlorpheniramine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1164,
24,
272
]
],
[
[
1164,
1,
358
],
[
358,
63,
272
]
],
[
[
1164,
1,
11244
],
[
11244,
1,
272
]
],
[
[
1164,
24,
849
],
[
849,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Trimipramine",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u} may c... | Trimipramine (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Trimipramine (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Chlorpheniramine (Compound)
Trimipramine may cause a m... |
DB01406 | DB09054 | 984 | 384 | [
"DDInter472",
"DDInter905"
] | Danazol | Idelalisib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
984,
24,
384
]
],
[
[
984,
62,
222
],
[
222,
23,
384
]
],
[
[
984,
63,
305
],
[
305,
24,
384
]
],
[
[
984,
40,
1687
],
[
1687,
2... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Danazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
"Si... | Danazol may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli... |
DB00264 | DB00986 | 88 | 1,192 | [
"DDInter1200",
"DDInter834"
] | Metoprolol | Glycopyrronium | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
88,
24,
1192
]
],
[
[
88,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
88,
24,
262
],
[
262,
24,
1192
]
],
[
[
88,
21,
29231
],
[
29231,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and C... |
DB00945 | DB01233 | 1,479 | 1,311 | [
"DDInter20",
"DDInter1197"
] | Acetylsalicylic acid | Metoclopramide | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Minor | 0 | [
[
[
1479,
23,
1311
]
],
[
[
1479,
10,
11610
],
[
11610,
49,
1311
]
],
[
[
1479,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1479,
63,
1252
],
[
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metoclopramide"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) palliates {v} (Disease)",
"migraine"
],
[
"migraine",
"{u} (D... | Acetylsalicylic acid (Compound) palliates migraine (Disease) and migraine (Disease) is palliated by Metoclopramide (Compound)
Acetylsalicylic acid (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Acetylsalicylic acid may cause a moderate interaction that cou... |
DB00417 | DB09268 | 1,667 | 1,662 | [
"DDInter1445",
"DDInter1464"
] | Phenoxymethylpenicillin | Picosulfuric acid | Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK. It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, s... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1667,
24,
1662
]
],
[
[
1667,
40,
319
],
[
319,
24,
1662
]
],
[
[
1667,
24,
361
],
[
361,
24,
1662
]
],
[
[
1667,
63,
964
],
[
964,
... | [
[
[
"Phenoxymethylpenicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Phenoxymethylpenicillin",
"{u} (Compound) resembles {v} (Compound)",
"Amoxicillin"
],
[
"Amoxicill... | Phenoxymethylpenicillin (Compound) resembles Amoxicillin (Compound) and Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Phenoxymethylpenicillin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a ... |
DB01177 | DB08904 | 77 | 375 | [
"DDInter904",
"DDInter342"
] | Idarubicin | Certolizumab pegol | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
77,
25,
375
]
],
[
[
77,
63,
1461
],
[
1461,
23,
375
]
],
[
[
77,
24,
200
],
[
200,
63,
375
]
],
[
[
77,
25,
1593
],
[
1593,
24,... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vit... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans ... |
DB03904 | DB11827 | 1,574 | 433 | [
"DDInter1903",
"DDInter669"
] | Urea | Ertugliflozin | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1574,
24,
433
]
],
[
[
1574,
24,
1455
],
[
1455,
24,
433
]
],
[
[
1574,
23,
1399
],
[
1399,
63,
433
]
],
[
[
1574,
63,
222
],
[
222,
... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
],
[
"Ni... | Urea may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid and Nitrous acid may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Urea may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate and Lithiu... |
DB00381 | DB00653 | 376 | 544 | [
"DDInter79",
"DDInter1120"
] | Amlodipine | Magnesium sulfate | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Moderate | 1 | [
[
[
376,
24,
544
]
],
[
[
376,
6,
2044
],
[
2044,
45,
544
]
],
[
[
376,
21,
28717
],
[
28717,
60,
544
]
],
[
[
376,
40,
854
],
[
854,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"CACNB2"
],
[
"CACNB2",
"{u} (Gene) is bound by {v} (Comp... | Amlodipine (Compound) binds CACNB2 (Gene) and CACNB2 (Gene) is bound by Magnesium sulfate (Compound)
Amlodipine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Magnesium sulfate (Compound)
Amlodipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interact... |
DB00333 | DB11837 | 576 | 1,297 | [
"DDInter1166",
"DDInter1351"
] | Methadone | Osilodrostat | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
576,
25,
1297
]
],
[
[
576,
23,
112
],
[
112,
23,
1297
]
],
[
[
576,
24,
222
],
[
222,
23,
1297
]
],
[
[
576,
25,
1320
],
[
1320,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Methadone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Methadone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sib... |
DB00281 | DB06717 | 608 | 875 | [
"DDInter1066",
"DDInter778"
] | Lidocaine | Fosaprepitant | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
608,
24,
875
]
],
[
[
608,
24,
723
],
[
723,
1,
875
]
],
[
[
608,
21,
29648
],
[
29648,
60,
875
]
],
[
[
608,
23,
1101
],
[
1101,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Lidocaine (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Fosaprepitant (Compound)
Lidocaine may cause a minor in... |
DB01114 | DB01178 | 272 | 369 | [
"DDInter362",
"DDInter357"
] | Chlorpheniramine | Chlormezanone | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Moderate | 1 | [
[
[
272,
24,
369
]
],
[
[
272,
24,
1532
],
[
1532,
63,
369
]
],
[
[
272,
63,
13
],
[
13,
24,
369
]
],
[
[
272,
74,
1376
],
[
1376,
2... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlormezanone"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cyproh... |
DB00877 | DB01233 | 629 | 1,311 | [
"DDInter1678",
"DDInter1197"
] | Sirolimus | Metoclopramide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
629,
24,
1311
]
],
[
[
629,
63,
1425
],
[
1425,
40,
1311
]
],
[
[
629,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
629,
63,
1010
],
[
1010... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisapride"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Sirolimus (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Sirolimus may cause a moderate interac... |
DB00581 | DB11228 | 355 | 721 | [
"DDInter1018",
"DDInter1184"
] | Lactulose | Methylcellulose | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum... | Moderate | 1 | [
[
[
355,
24,
721
]
],
[
[
355,
40,
1647
],
[
1647,
23,
721
]
],
[
[
355,
23,
16
],
[
16,
23,
721
]
],
[
[
355,
24,
1662
],
[
1662,
2... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylcellulose"
]
],
[
[
"Lactulose",
"{u} (Compound) resembles {v} (Compound)",
"Acarbose"
],
[
"Acarbose",
"{u} may cause a minor in... | Lactulose (Compound) resembles Acarbose (Compound) and Acarbose may cause a minor interaction that can limit clinical effects when taken with Methylcellulose
Lactulose may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit c... |
DB00470 | DB01563 | 530 | 680 | [
"DDInter601",
"DDInter349"
] | Dronabinol | Chloral hydrate | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. | Moderate | 1 | [
[
[
530,
24,
680
]
],
[
[
530,
24,
272
],
[
272,
24,
680
]
],
[
[
530,
1,
1614
],
[
1614,
24,
680
]
],
[
[
530,
25,
593
],
[
593,
24... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloral hydrate"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Dronabinol (Compound) resembles Nabilone (Compound) and Nabilone may cause a moderate interacti... |
DB00374 | DB00861 | 1,061 | 914 | [
"DDInter1852",
"DDInter551"
] | Treprostinil | Diflunisal | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
1061,
24,
914
]
],
[
[
1061,
7,
7720
],
[
7720,
45,
914
]
],
[
[
1061,
7,
7483
],
[
7483,
46,
914
]
],
[
[
1061,
21,
29209
],
[
29209,... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Treprostinil",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Com... | Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Diflunisal (Compound)
Treprostinil (Compound) upregulates HLA-DMA (Gene) and HLA-DMA (Gene) is upregulated by Diflunisal (Compound)
Treprostinil (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diflunisal (Comp... |
DB00976 | DB01234 | 1,056 | 1,220 | [
"DDInter1758",
"DDInter513"
] | Telithromycin | Dexamethasone | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1056,
24,
1220
]
],
[
[
1056,
63,
870
],
[
870,
1,
1220
]
],
[
[
1056,
64,
175
],
[
175,
40,
1220
]
],
[
[
1056,
25,
617
],
[
617,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Telithromycin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethason... |
DB00238 | DB05812 | 188 | 1,374 | [
"DDInter1285",
"DDInter8"
] | Nevirapine | Abiraterone | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
188,
24,
1374
]
],
[
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188,
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],
[
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60,
1374
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],
[
[
188,
24,
466
],
[
466,... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Nevirapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Nevirapine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and ... |
DB00215 | DB01225 | 1,230 | 500 | [
"DDInter388",
"DDInter645"
] | Citalopram | Enoxaparin | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Moderate | 1 | [
[
[
1230,
24,
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],
[
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[
29173,
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],
[
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[
1039,
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]
],
[
[
1230,
1,
318
],
[
318,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
]
],
[
[
"Citalopram",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema peripheral"
],
[
"Oedema peripheral",
"{u} (Side... | Citalopram (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Citalopram may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00916 | DB11642 | 112 | 938 | [
"DDInter1202",
"DDInter1480"
] | Metronidazole | Pitolisant | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Minor | 0 | [
[
[
112,
23,
938
]
],
[
[
112,
62,
600
],
[
600,
24,
938
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],
[
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23,
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[
1228,
24,
938
]
],
[
[
112,
23,
927
],
[
927,
6... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pitolisant"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fluconazole"
],
[... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib and Le... |
DB00512 | DB01432 | 91 | 857 | [
"DDInter1916",
"DDInter368"
] | Vancomycin | Cholestyramine | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water. | Moderate | 1 | [
[
[
91,
24,
857
]
],
[
[
91,
24,
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],
[
1512,
23,
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],
[
[
91,
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629
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[
629,
24,
857
]
],
[
[
91,
24,
1096
],
[
1096,
25,... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholestyramine"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a minor interaction that can limit clinical effects when taken with Cholestyramine
Vancomycin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause ... |
DB00108 | DB10315 | 1,066 | 1,137 | [
"DDInter1268",
"DDInter1127"
] | Natalizumab | Measles virus vaccine live attenuated | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1066,
25,
1137
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],
[
[
1066,
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],
[
1042,
24,
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[
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],
[
119,
64,
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],
[
[
1066,
64,
273
],
[
273,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetracosactide"
],
[... | Natalizumab may lead to a major life threatening interaction when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Natalizumab may lead to a major life threatening interaction when taken with Talazoparib an... |
DB01156 | DB01233 | 593 | 1,311 | [
"DDInter252",
"DDInter1197"
] | Bupropion | Metoclopramide | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
593,
25,
1311
]
],
[
[
593,
6,
12523
],
[
12523,
45,
1311
]
],
[
[
593,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
593,
64,
1010
],
[
101... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Bupropion",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Metoc... | Bupropion (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Bupropion (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Bupropion may lead to a major life threatening interaction when taken with Mefloquine and Mefloquine m... |
DB00694 | DB08901 | 51 | 1,468 | [
"DDInter485",
"DDInter1492"
] | Daunorubicin | Ponatinib | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
51,
24,
1468
]
],
[
[
51,
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478
],
[
478,
24,
1468
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],
[
[
51,
6,
10083
],
[
10083,
45,
1468
]
],
[
[
51,
18,
2030
],
[
2030,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotini... | Daunorubicin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Daunorubicin (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Ponatinib (Compound)
Daunorubicin (Compound) downregul... |
DB00402 | DB01142 | 1,407 | 1,264 | [
"DDInter685",
"DDInter593"
] | Eszopiclone | Doxepin | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1407,
24,
1264
]
],
[
[
1407,
24,
401
],
[
401,
24,
1264
]
],
[
[
1407,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
1407,
24,
649
],
[
649,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Dox... |
DB00001 | DB11793 | 1,578 | 738 | [
"DDInter1037",
"DDInter1297"
] | Lepirudin | Niraparib | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1578,
24,
738
]
],
[
[
1578,
25,
1213
],
[
1213,
24,
738
]
],
[
[
1578,
24,
848
],
[
848,
24,
738
]
],
[
[
1578,
25,
1650
],
[
1650,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Lepirudin may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moder... |
DB06176 | DB06788 | 1,342 | 1,616 | [
"DDInter1616",
"DDInter864"
] | Romidepsin | Histrelin | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1342,
24,
1616
]
],
[
[
1342,
62,
112
],
[
112,
23,
1616
]
],
[
[
1342,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
1342,
24,
603
],
[
603,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risp... |
DB00033 | DB00060 | 342 | 912 | [
"DDInter949",
"DDInter947"
] | Interferon gamma-1b | Interferon beta-1a | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Moderate | 1 | [
[
[
342,
24,
912
]
],
[
[
342,
24,
1662
],
[
1662,
63,
912
]
],
[
[
342,
63,
305
],
[
305,
24,
912
]
],
[
[
342,
25,
1101
],
[
1101,
... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"P... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseas... |
DB00502 | DB08875 | 1,300 | 1,618 | [
"DDInter853",
"DDInter262"
] | Haloperidol | Cabozantinib | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1300,
25,
1618
]
],
[
[
1300,
23,
112
],
[
112,
23,
1618
]
],
[
[
1300,
24,
723
],
[
723,
24,
1618
]
],
[
[
1300,
24,
384
],
[
384,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Haloperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Haloperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and ... |
DB00877 | DB10315 | 629 | 1,137 | [
"DDInter1678",
"DDInter1127"
] | Sirolimus | Measles virus vaccine live attenuated | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
629,
25,
1137
]
],
[
[
629,
24,
617
],
[
617,
24,
1137
]
],
[
[
629,
64,
581
],
[
581,
25,
1137
]
],
[
[
629,
25,
384
],
[
384,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Sirolimus may lead to a major life threatening interaction when taken with Infliximab ... |
DB00078 | DB10316 | 1,172 | 334 | [
"DDInter898",
"DDInter1248"
] | Ibritumomab tiuxetan | Mumps virus strain B level jeryl lynn live antigen | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1172,
25,
334
]
],
[
[
1172,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1172,
25,
908
],
[
908,
25,
334
]
],
[
[
1172,
24,
599
],
[
599,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Golimu... |
DB00465 | DB05773 | 886 | 1,047 | [
"DDInter1010",
"DDInter1848"
] | Ketorolac | Trastuzumab emtansine | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
886,
24,
1047
]
],
[
[
886,
25,
848
],
[
848,
24,
1047
]
],
[
[
886,
24,
1613
],
[
1613,
63,
1047
]
],
[
[
886,
63,
912
],
[
912,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibuprofen"
],
[
"Ib... | Ketorolac may lead to a major life threatening interaction when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peg... |
DB00092 | DB09054 | 58 | 384 | [
"DDInter40",
"DDInter905"
] | Alefacept | Idelalisib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
58,
24,
384
]
],
[
[
58,
24,
725
],
[
725,
63,
384
]
],
[
[
58,
24,
328
],
[
328,
24,
384
]
],
[
[
58,
63,
305
],
[
305,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and ... |
DB05812 | DB06605 | 1,374 | 1,409 | [
"DDInter8",
"DDInter108"
] | Abiraterone | Apixaban | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
1374,
24,
1409
]
],
[
[
1374,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
1374,
21,
28787
],
[
28787,
60,
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]
],
[
[
1374,
63,
109
],
[
10... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Abiraterone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",... | Abiraterone (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Abiraterone (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Dul... |
DB00969 | DB09074 | 2 | 1,362 | [
"DDInter52",
"DDInter1327"
] | Alosetron | Olaparib | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
2,
24,
1362
]
],
[
[
2,
63,
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],
[
1684,
24,
1362
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],
[
[
2,
24,
1619
],
[
1619,
63,
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]
],
[
[
2,
24,
86
],
[
86,
24,
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caffeine"
],
[
"C... | Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may c... |
DB01242 | DB11901 | 1,237 | 913 | [
"DDInter410",
"DDInter107"
] | Clomipramine | Apalutamide | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1237,
24,
913
]
],
[
[
1237,
62,
112
],
[
112,
23,
913
]
],
[
[
1237,
63,
600
],
[
600,
24,
913
]
],
[
[
1237,
40,
1178
],
[
1178,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Clomipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Clomipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB08889 | DB13007 | 350 | 1,060 | [
"DDInter299",
"DDInter642"
] | Carfilzomib | Enfortumab vedotin | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
350,
24,
1060
]
],
[
[
350,
63,
1593
],
[
1593,
24,
1060
]
],
[
[
350,
24,
270
],
[
270,
24,
1060
]
],
[
[
350,
64,
1011
],
[
1011,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab... |
DB00572 | DB00679 | 85 | 684 | [
"DDInter136",
"DDInter1796"
] | Atropine | Thioridazine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
85,
24,
684
]
],
[
[
85,
24,
1237
],
[
1237,
40,
684
]
],
[
[
85,
63,
216
],
[
216,
1,
684
]
],
[
[
85,
24,
9
],
[
9,
1,
6... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thioridazine... |
DB00106 | DB01059 | 618 | 956 | [
"DDInter4",
"DDInter1313"
] | Abarelix | Norfloxacin | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
618,
24,
956
]
],
[
[
618,
24,
872
],
[
872,
40,
956
]
],
[
[
618,
25,
1176
],
[
1176,
1,
956
]
],
[
[
618,
24,
1539
],
[
1539,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Abarelix may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Abarelix ... |
DB00604 | DB00757 | 1,425 | 1,166 | [
"DDInter385",
"DDInter581"
] | Cisapride | Dolasetron | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1425,
25,
1166
]
],
[
[
1425,
63,
19
],
[
19,
40,
1166
]
],
[
[
1425,
63,
85
],
[
85,
1,
1166
]
],
[
[
1425,
6,
12523
],
[
12523,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamine... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
Cisa... |
DB00321 | DB00981 | 21 | 1,528 | [
"DDInter78",
"DDInter1462"
] | Amitriptyline | Physostigmine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
21,
24,
1528
]
],
[
[
21,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
21,
1,
508
],
[
508,
24,
1528
]
],
[
[
21,
24,
1511
],
[
1511,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Amitriptyline",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effe... | Amitriptyline (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Amitriptyline (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Amitriptyline may cause a modera... |
DB00593 | DB00792 | 1,464 | 832 | [
"DDInter695",
"DDInter1878"
] | Ethosuximide | Tripelennamine | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1464,
24,
832
]
],
[
[
1464,
24,
100
],
[
100,
63,
832
]
],
[
[
1464,
24,
649
],
[
649,
1,
832
]
],
[
[
1464,
63,
1594
],
[
1594,
... | [
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Ethosuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ethosuximide may cause a moderate interaction that could exacerbate diseases when taken with Clo... |
DB01114 | DB01142 | 272 | 1,264 | [
"DDInter362",
"DDInter593"
] | Chlorpheniramine | Doxepin | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
272,
24,
1264
]
],
[
[
272,
74,
508
],
[
508,
24,
1264
]
],
[
[
272,
63,
401
],
[
401,
24,
1264
]
],
[
[
272,
40,
11439
],
[
11439,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases whe... | Chlorpheniramine (Compound) resembles Promazine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Chlorpheniramine may cause a moderate interactio... |
DB01118 | DB09134 | 33 | 1,552 | [
"DDInter76",
"DDInter966"
] | Amiodarone | Ioversol | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
33,
24,
1552
]
],
[
[
33,
24,
1074
],
[
1074,
63,
1552
]
],
[
[
33,
25,
116
],
[
116,
63,
1552
]
],
[
[
33,
64,
589
],
[
589,
25... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
],
[
... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Amiodarone may lead to a major life threatening interaction when taken with Iodide I-131 and Iodide I-131 may ... |
DB00283 | DB11732 | 701 | 1,097 | [
"DDInter395",
"DDInter1027"
] | Clemastine | Lasmiditan | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
701,
24,
1097
]
],
[
[
701,
24,
1614
],
[
1614,
24,
1097
]
],
[
[
701,
35,
1242
],
[
1242,
24,
1097
]
],
[
[
701,
24,
1053
],
[
1053,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Clemastine (Compound) resembles Cetirizine (Compound) and Clemastine may cause a moderate interaction that could exa... |
DB00842 | DB12130 | 686 | 1,017 | [
"DDInter1359",
"DDInter1094"
] | Oxazepam | Lorlatinib | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
686,
24,
1017
]
],
[
[
686,
63,
608
],
[
608,
23,
1017
]
],
[
[
686,
40,
1274
],
[
1274,
24,
1017
]
],
[
[
686,
24,
222
],
[
222,
... | [
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"... | Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Oxazepam (Compound) resembles Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exa... |
DB00526 | DB05260 | 1,555 | 1,329 | [
"DDInter1355",
"DDInter804"
] | Oxaliplatin | Gallium nitrate | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for... | Moderate | 1 | [
[
[
1555,
24,
1329
]
],
[
[
1555,
24,
712
],
[
712,
24,
1329
]
],
[
[
1555,
24,
361
],
[
361,
25,
1329
]
],
[
[
1555,
24,
712
],
[
712,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gallium nitrate"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and N... |
DB00106 | DB00816 | 618 | 1,674 | [
"DDInter4",
"DDInter1346"
] | Abarelix | Orciprenaline | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
618,
24,
1674
]
],
[
[
618,
24,
1164
],
[
1164,
24,
1674
]
],
[
[
618,
24,
484
],
[
484,
63,
1674
]
],
[
[
618,
25,
880
],
[
880,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
],
[
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and En... |
DB00794 | DB06335 | 759 | 761 | [
"DDInter1521",
"DDInter1646"
] | Primidone | Saxagliptin | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
759,
24,
761
]
],
[
[
759,
6,
8374
],
[
8374,
45,
761
]
],
[
[
759,
21,
28722
],
[
28722,
60,
761
]
],
[
[
759,
25,
1491
],
[
1491,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Primidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Primidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Primidone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Primidone may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a m... |
DB00927 | DB06626 | 1,559 | 263 | [
"DDInter712",
"DDInter147"
] | Famotidine | Axitinib | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Minor | 0 | [
[
[
1559,
23,
263
]
],
[
[
1559,
23,
1384
],
[
1384,
62,
263
]
],
[
[
1559,
23,
1283
],
[
1283,
23,
263
]
],
[
[
1559,
63,
322
],
[
322,
... | [
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Axitinib"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
],
[
"M... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a minor interaction that can limit clinical effects when taken with Axitinib
Famotidine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide and Magnesium... |
DB00372 | DB03128 | 999 | 140 | [
"DDInter1793",
"DDInter18"
] | Thiethylperazine | Acetylcholine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Moderate | 1 | [
[
[
999,
24,
140
]
],
[
[
999,
24,
1376
],
[
1376,
24,
140
]
],
[
[
999,
63,
352
],
[
352,
24,
140
]
],
[
[
999,
24,
1116
],
[
1116,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylcholine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydram... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Acetylcholine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00928 | DB08880 | 1,426 | 1,510 | [
"DDInter148",
"DDInter1771"
] | Azacitidine | Teriflunomide | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1426,
25,
1510
]
],
[
[
1426,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
1426,
24,
221
],
[
221,
63,
1510
]
],
[
[
1426,
24,
1136
],
[
1136... | [
[
[
"Azacitidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 an... |
DB00023 | DB00851 | 305 | 611 | [
"DDInter127",
"DDInter463"
] | Asparaginase Escherichia coli | Dacarbazine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
305,
24,
611
]
],
[
[
305,
24,
1176
],
[
1176,
23,
611
]
],
[
[
305,
24,
850
],
[
850,
63,
611
]
],
[
[
305,
24,
66
],
[
66,
24,... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate disea... |
DB00757 | DB00774 | 1,166 | 1,577 | [
"DDInter581",
"DDInter889"
] | Dolasetron | Hydroflumethiazide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Major | 2 | [
[
[
1166,
25,
1577
]
],
[
[
1166,
25,
359
],
[
359,
40,
1577
]
],
[
[
1166,
64,
323
],
[
323,
40,
1577
]
],
[
[
1166,
25,
504
],
[
504,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chlorothiazide"
],
[
"Chlorothiazid... | Dolasetron may lead to a major life threatening interaction when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) resembles Hydroflumethiazide... |
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