drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00780 | DB09488 | 551 | 103 | [
"DDInter1440",
"DDInter23"
] | Phenelzine | Acrivastine | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
551,
24,
103
]
],
[
[
551,
62,
85
],
[
85,
24,
103
]
],
[
[
551,
25,
1264
],
[
1264,
24,
103
]
],
[
[
551,
23,
1123
],
[
1123,
2... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Phenelzine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Atropine"
],
[
... | Phenelzine may cause a minor interaction that can limit clinical effects when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Phenelzine may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate ... |
DB01042 | DB01073 | 1,307 | 1,488 | [
"DDInter1144",
"DDInter745"
] | Melphalan | Fludarabine | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
1307,
24,
1488
]
],
[
[
1307,
63,
372
],
[
372,
1,
1488
]
],
[
[
1307,
5,
11555
],
[
11555,
44,
1488
]
],
[
[
1307,
21,
29106
],
[
291... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Melphalan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Fludarabine (Compound)
Melphalan (Compound) causes Mya... |
DB00060 | DB11791 | 912 | 785 | [
"DDInter947",
"DDInter287"
] | Interferon beta-1a | Capmatinib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
912,
24,
785
]
],
[
[
912,
24,
1324
],
[
1324,
24,
785
]
],
[
[
912,
24,
1320
],
[
1320,
63,
785
]
],
[
[
912,
63,
1560
],
[
1560,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazon... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with E... |
DB00552 | DB08868 | 1,238 | 1,011 | [
"DDInter1425",
"DDInter737"
] | Pentostatin | Fingolimod | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1238,
25,
1011
]
],
[
[
1238,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
1238,
24,
748
],
[
748,
63,
1011
]
],
[
[
1238,
24,
1136
],
[
11... | [
[
[
"Pentostatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Pentostatin",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Effect) is caused ... | Pentostatin (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases w... |
DB00407 | DB01240 | 202 | 885 | [
"DDInter115",
"DDInter657"
] | Ardeparin | Epoprostenol | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Major | 2 | [
[
[
202,
25,
885
]
],
[
[
202,
64,
1061
],
[
1061,
1,
885
]
],
[
[
202,
21,
28642
],
[
28642,
60,
885
]
],
[
[
202,
25,
1512
],
[
1512,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
]
],
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Treprostinil"
],
[
"Treprostinil",
"{... | Ardeparin may lead to a major life threatening interaction when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Ardeparin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Epoprostenol (Compound)
Ardeparin may lead to a major life threatening interaction wh... |
DB00443 | DB00457 | 251 | 1,205 | [
"DDInter195",
"DDInter1511"
] | Betamethasone | Prazosin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Moderate | 1 | [
[
[
251,
24,
1205
]
],
[
[
251,
24,
195
],
[
195,
1,
1205
]
],
[
[
251,
6,
4973
],
[
4973,
45,
1205
]
],
[
[
251,
7,
16662
],
[
16662,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
],
[... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Terazosin and Terazosin (Compound) resembles Prazosin (Compound)
Betamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Prazosin (Compound)
Betamethasone (Compound) upregulates SQRDL (Gene) and SQRDL (Gene) i... |
DB00196 | DB00252 | 600 | 362 | [
"DDInter743",
"DDInter1460"
] | Fluconazole | Phenytoin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Major | 2 | [
[
[
600,
25,
362
]
],
[
[
600,
23,
307
],
[
307,
1,
362
]
],
[
[
600,
23,
697
],
[
697,
40,
362
]
],
[
[
600,
25,
126
],
[
126,
63,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenytoin"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Phenytoin (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Phenobarbital and Phenobarbital (Compound) resembles Phenytoin (Compound)
... |
DB00377 | DB01041 | 1,494 | 770 | [
"DDInter1382",
"DDInter1789"
] | Palonosetron | Thalidomide | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1494,
24,
770
]
],
[
[
1494,
6,
7950
],
[
7950,
45,
770
]
],
[
[
1494,
21,
29425
],
[
29425,
60,
770
]
],
[
[
1494,
24,
609
],
[
609,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compou... | Palonosetron (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thalidomide (Compound)
Palonosetron (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when ... |
DB00092 | DB01073 | 58 | 1,488 | [
"DDInter40",
"DDInter745"
] | Alefacept | Fludarabine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
58,
24,
1488
]
],
[
[
58,
24,
1426
],
[
1426,
1,
1488
]
],
[
[
58,
24,
975
],
[
975,
63,
1488
]
],
[
[
58,
24,
134
],
[
134,
24,... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Fludarabine (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin and Lurbinectedin may cause a moderate interaction tha... |
DB00341 | DB11823 | 1,242 | 858 | [
"DDInter343",
"DDInter673"
] | Cetirizine | Esketamine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Moderate | 1 | [
[
[
1242,
24,
858
]
],
[
[
1242,
24,
272
],
[
272,
24,
858
]
],
[
[
1242,
63,
475
],
[
475,
24,
858
]
],
[
[
1242,
74,
701
],
[
701,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esketamine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Morphine ... |
DB08885 | DB10276 | 363 | 1,624 | [
"DDInter33",
"DDInter1623"
] | Aflibercept | Rotavirus vaccine | Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Dalt... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
363,
25,
1624
]
],
[
[
363,
25,
375
],
[
375,
25,
1624
]
],
[
[
363,
63,
58
],
[
58,
25,
1624
]
],
[
[
363,
64,
908
],
[
908,
25... | [
[
[
"Aflibercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Aflibercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
],
[
"Certoliz... | Aflibercept may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may lead to a major life threatening interaction when taken with Rotavirus vaccine
Aflibercept may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept ma... |
DB00959 | DB06710 | 1,486 | 1,546 | [
"DDInter1191",
"DDInter1193"
] | Methylprednisolone | Methyltestosterone | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
1486,
24,
1546
]
],
[
[
1486,
40,
1581
],
[
1581,
1,
1546
]
],
[
[
1486,
63,
312
],
[
312,
1,
1546
]
],
[
[
1486,
24,
155
],
[
155,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Testolactone"
],
[
"Testolactone",
... | Methylprednisolone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Methyltestosterone (Compound)
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone (Compound) resembles Methyltestosterone (Compound)
Methylpredni... |
DB00023 | DB08889 | 305 | 350 | [
"DDInter127",
"DDInter299"
] | Asparaginase Escherichia coli | Carfilzomib | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
305,
24,
350
]
],
[
[
305,
24,
1270
],
[
1270,
63,
350
]
],
[
[
305,
24,
482
],
[
482,
24,
350
]
],
[
[
305,
63,
1451
],
[
1451,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Asparaginase Escherichia coli may ca... |
DB00812 | DB00877 | 998 | 629 | [
"DDInter1451",
"DDInter1678"
] | Phenylbutazone | Sirolimus | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
998,
25,
629
]
],
[
[
998,
6,
8374
],
[
8374,
45,
629
]
],
[
[
998,
18,
5660
],
[
5660,
46,
629
]
],
[
[
998,
24,
1476
],
[
1476,
... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Phenylbutazone (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is upregulated by Sirolimus (Compound)
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brig... |
DB00001 | DB05773 | 1,578 | 1,047 | [
"DDInter1037",
"DDInter1848"
] | Lepirudin | Trastuzumab emtansine | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Major | 2 | [
[
[
1578,
25,
1047
]
],
[
[
1578,
24,
848
],
[
848,
24,
1047
]
],
[
[
1578,
24,
643
],
[
643,
63,
1047
]
],
[
[
1578,
25,
932
],
[
932,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ib... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine... |
DB00078 | DB00574 | 1,172 | 121 | [
"DDInter898",
"DDInter717"
] | Ibritumomab tiuxetan | Fenfluramine | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
1172,
24,
121
]
],
[
[
1172,
64,
366
],
[
366,
24,
121
]
],
[
[
1172,
25,
24
],
[
24,
24,
121
]
],
[
[
1172,
25,
292
],
[
292,
6... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Tolmetin and Tolmetin may... |
DB00176 | DB09472 | 529 | 1,383 | [
"DDInter770",
"DDInter1693"
] | Fluvoxamine | Sodium sulfate | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
529,
24,
1383
]
],
[
[
529,
24,
609
],
[
609,
24,
1383
]
],
[
[
529,
25,
1466
],
[
1466,
24,
1383
]
],
[
[
529,
24,
971
],
[
971,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Fluvoxamine may lead to a major life threatening interaction when taken with Phenylpropanolamine an... |
DB00726 | DB01041 | 1,164 | 770 | [
"DDInter1876",
"DDInter1789"
] | Trimipramine | Thalidomide | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1164,
24,
770
]
],
[
[
1164,
6,
10215
],
[
10215,
45,
770
]
],
[
[
1164,
7,
7669
],
[
7669,
46,
770
]
],
[
[
1164,
21,
28784
],
[
2878... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Trimipramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Comp... | Trimipramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Thalidomide (Compound)
Trimipramine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Trimipramine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Thal... |
DB01232 | DB11793 | 1,327 | 738 | [
"DDInter1640",
"DDInter1297"
] | Saquinavir | Niraparib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1327,
24,
738
]
],
[
[
1327,
24,
466
],
[
466,
63,
738
]
],
[
[
1327,
25,
1213
],
[
1213,
24,
738
]
],
[
[
1327,
25,
1619
],
[
1619,
... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Saquinavir may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause... |
DB00927 | DB14509 | 1,559 | 1,399 | [
"DDInter712",
"DDInter1081"
] | Famotidine | Lithium carbonate | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1559,
24,
1399
]
],
[
[
1559,
24,
1374
],
[
1374,
24,
1399
]
],
[
[
1559,
63,
1010
],
[
1010,
24,
1399
]
],
[
[
1559,
25,
1213
],
[
12... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB00209 | DB00808 | 352 | 1,605 | [
"DDInter1886",
"DDInter916"
] | Trospium | Indapamide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Minor | 0 | [
[
[
352,
23,
1605
]
],
[
[
352,
23,
811
],
[
811,
1,
1605
]
],
[
[
352,
21,
28868
],
[
28868,
60,
1605
]
],
[
[
352,
24,
1511
],
[
1511,
... | [
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
]
],
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
],
[
"Met... | Trospium may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Trospium (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Indapamide (Compound)
Trospium may cause a moderate interaction that c... |
DB00631 | DB01005 | 372 | 995 | [
"DDInter405",
"DDInter894"
] | Clofarabine | Hydroxyurea | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
372,
24,
995
]
],
[
[
372,
5,
11555
],
[
11555,
44,
995
]
],
[
[
372,
6,
4362
],
[
4362,
45,
995
]
],
[
[
372,
21,
29429
],
[
29429,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Clofarabine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Dis... | Clofarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Hydroxyurea (Compound)
Clofarabine (Compound) binds RRM1 (Gene) and RRM1 (Gene) is bound by Hydroxyurea (Compound)
Clofarabine (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is ca... |
DB00995 | DB08901 | 1,112 | 1,468 | [
"DDInter139",
"DDInter1492"
] | Auranofin | Ponatinib | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1112,
24,
1468
]
],
[
[
1112,
7,
7478
],
[
7478,
46,
1468
]
],
[
[
1112,
6,
2067
],
[
2067,
46,
1468
]
],
[
[
1112,
18,
1982
],
[
1982... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Auranofin",
"{u} (Compound) upregulates {v} (Gene)",
"TRAPPC6A"
],
[
"TRAPPC6A",
"{u} (Gene) is upregulated by {v}... | Auranofin (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ponatinib (Compound)
Auranofin (Compound) binds IKBKB (Gene) and IKBKB (Gene) is upregulated by Ponatinib (Compound)
Auranofin (Compound) downregulates CCT5 (Gene) and CCT5 (Gene) is downregulated by Ponatinib (Compound)
Auranofin (C... |
DB01116 | DB09112 | 601 | 1,455 | [
"DDInter1872",
"DDInter1306"
] | Trimethaphan | Nitrous acid | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
601,
24,
1455
]
],
[
[
601,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
601,
40,
762
],
[
762,
24,
1455
]
],
[
[
601,
63,
714
],
[
714,
... | [
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Trimethaphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],... | Trimethaphan may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Trimethaphan (Compound) resembles Bepridil (Compound) and Bepridil may cause a moderate interaction th... |
DB01220 | DB15444 | 1,088 | 683 | [
"DDInter1593",
"DDInter628"
] | Rifaximin | Elexacaftor | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It received FDA approval in October 2019 in combination with [tezacaftor] and [ivacaftor] as the combination product Trikafta<sup>TM</sup>. Elexacaftor is considered ... | Moderate | 1 | [
[
[
1088,
24,
683
]
],
[
[
1088,
6,
8374
],
[
8374,
45,
473
],
[
473,
24,
683
]
],
[
[
1088,
21,
28763
],
[
28763,
60,
473
],
[
473,
24,... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elexacaftor"
]
],
[
[
"Rifaximin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Rifaximin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound) and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Elexacaftor
Rifaximin (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Repaglinide (Compound) ... |
DB00270 | DB11718 | 1,428 | 927 | [
"DDInter993",
"DDInter640"
] | Isradipine | Encorafenib | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1428,
24,
927
]
],
[
[
1428,
1,
84
],
[
84,
24,
927
]
],
[
[
1428,
24,
1010
],
[
1010,
24,
927
]
],
[
[
1428,
24,
484
],
[
484,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Isradipine",
"{u} (Compound) resembles {v} (Compound)",
"Nisoldipine"
],
[
"Nisoldipine",
"{u} may cause a mode... | Isradipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that co... |
DB00640 | DB11837 | 1,585 | 1,297 | [
"DDInter31",
"DDInter1351"
] | Adenosine | Osilodrostat | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1585,
24,
1297
]
],
[
[
1585,
23,
578
],
[
578,
24,
1297
]
],
[
[
1585,
24,
401
],
[
401,
24,
1297
]
],
[
[
1585,
63,
1555
],
[
1555,
... | [
[
[
"Adenosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Adenosine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
],
[
... | Adenosine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promet... |
DB01009 | DB11901 | 935 | 913 | [
"DDInter1009",
"DDInter107"
] | Ketoprofen | Apalutamide | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
935,
24,
913
]
],
[
[
935,
25,
1468
],
[
1468,
24,
913
]
],
[
[
935,
24,
877
],
[
877,
63,
913
]
],
[
[
935,
24,
1662
],
[
1662,
... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib"... | Ketoprofen may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin and Macimorelin may cause... |
DB00397 | DB13139 | 1,466 | 1,032 | [
"DDInter1458",
"DDInter1063"
] | Phenylpropanolamine | Levosalbutamol | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1466,
24,
1032
]
],
[
[
1466,
25,
121
],
[
121,
24,
1032
]
],
[
[
1466,
64,
73
],
[
73,
24,
1032
]
],
[
[
1466,
24,
1048
],
[
1048,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
],... | Phenylpropanolamine may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Phenylpropanolamine may lead to a major life threatening interaction when taken with Phentermine and Phentermi... |
DB00851 | DB14811 | 611 | 385 | [
"DDInter463",
"DDInter979"
] | Dacarbazine | Isatuximab | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
611,
24,
385
]
],
[
[
611,
24,
1362
],
[
1362,
24,
385
]
],
[
[
611,
63,
377
],
[
377,
24,
385
]
],
[
[
611,
64,
1648
],
[
1648,
... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin... |
DB00358 | DB00850 | 1,010 | 1,630 | [
"DDInter1140",
"DDInter1432"
] | Mefloquine | Perphenazine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
1010,
24,
1630
]
],
[
[
1010,
24,
252
],
[
252,
40,
1630
]
],
[
[
1010,
25,
684
],
[
684,
40,
1630
]
],
[
[
1010,
6,
12523
],
[
12523,... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Perphenazine (Compound)
Meflo... |
DB00220 | DB01124 | 798 | 1,411 | [
"DDInter1276",
"DDInter1828"
] | Nelfinavir | Tolbutamide | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
798,
24,
1411
]
],
[
[
798,
24,
959
],
[
959,
40,
1411
]
],
[
[
798,
6,
10215
],
[
10215,
45,
1411
]
],
[
[
798,
18,
15501
],
[
15501,... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Nelfinavir (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tolbutamide (Compound)
Nelfinavir (Compound) downregulates CCDC86 (Gene) and CCDC86 (Ge... |
DB01240 | DB01242 | 885 | 1,237 | [
"DDInter657",
"DDInter410"
] | Epoprostenol | Clomipramine | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
885,
24,
1237
]
],
[
[
885,
21,
28703
],
[
28703,
60,
1237
]
],
[
[
885,
63,
1578
],
[
1578,
24,
1237
]
],
[
[
885,
24,
397
],
[
397,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Epoprostenol",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is ... | Epoprostenol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Clomipramine (Compound)
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomi... |
DB01404 | DB06441 | 757 | 936 | [
"DDInter820",
"DDInter283"
] | Ginseng | Cangrelor | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
757,
24,
936
]
],
[
[
757,
63,
1271
],
[
1271,
25,
936
]
],
[
[
757,
24,
1046
],
[
1046,
25,
936
]
],
[
[
757,
24,
802
],
[
802,
... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alteplase"
],
[
"Alt... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Alteplase and Alteplase may lead to a major life threatening interaction when taken with Cangrelor
Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab and Caplacizumab may lead to a m... |
DB00798 | DB00963 | 1,132 | 1,263 | [
"DDInter815",
"DDInter241"
] | Gentamicin | Bromfenac | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
1132,
24,
1263
]
],
[
[
1132,
24,
935
],
[
935,
40,
1263
]
],
[
[
1132,
63,
831
],
[
831,
40,
1263
]
],
[
[
1132,
63,
1512
],
[
1512,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (Compound... |
DB09104 | DB11837 | 286 | 1,297 | [
"DDInter1118",
"DDInter1351"
] | Magnesium hydroxide | Osilodrostat | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
286,
24,
1297
]
],
[
[
286,
63,
623
],
[
623,
24,
1297
]
],
[
[
286,
62,
401
],
[
401,
24,
1297
]
],
[
[
286,
24,
971
],
[
971,
... | [
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiap... | Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Pro... |
DB00252 | DB06589 | 362 | 1,250 | [
"DDInter1460",
"DDInter1400"
] | Phenytoin | Pazopanib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
362,
24,
1250
]
],
[
[
362,
6,
3486
],
[
3486,
45,
1250
]
],
[
[
362,
7,
6858
],
[
6858,
46,
1250
]
],
[
[
362,
18,
11146
],
[
11146,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Phenytoin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pazopanib (Compound)
Phenytoin (Compound) upregulates LPL (Gene) and LPL (Gene) is upregulated by Pazopanib (Compound)
Phenytoin (Compound) downregulates AMIGO2 (Gene) and AMIGO2 (Gene) is downregulated by Pazopanib (Compound)
Phenytoin (Compound) c... |
DB00339 | DB00563 | 1,182 | 663 | [
"DDInter1547",
"DDInter1174"
] | Pyrazinamide | Methotrexate | A pyrazine that is used therapeutically as an antitubercular agent. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1182,
24,
663
]
],
[
[
1182,
6,
5523
],
[
5523,
45,
663
]
],
[
[
1182,
21,
28681
],
[
28681,
60,
663
]
],
[
[
1182,
63,
1560
],
[
1560... | [
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Pyrazinamide",
"{u} (Compound) binds {v} (Gene)",
"AOX1"
],
[
"AOX1",
"{u} (Gene) is bound by {v} (Compound)... | Pyrazinamide (Compound) binds AOX1 (Gene) and AOX1 (Gene) is bound by Methotrexate (Compound)
Pyrazinamide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00675 | DB00794 | 888 | 759 | [
"DDInter1744",
"DDInter1521"
] | Tamoxifen | Primidone | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
888,
24,
759
]
],
[
[
888,
24,
697
],
[
697,
40,
759
]
],
[
[
888,
63,
362
],
[
362,
1,
759
]
],
[
[
888,
6,
6017
],
[
6017,
45,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound)
... |
DB00685 | DB00912 | 1,299 | 473 | [
"DDInter1887",
"DDInter1581"
] | Trovafloxacin | Repaglinide | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Major | 2 | [
[
[
1299,
25,
473
]
],
[
[
1299,
21,
28873
],
[
28873,
60,
473
]
],
[
[
1299,
63,
1512
],
[
1512,
24,
473
]
],
[
[
1299,
24,
433
],
[
433,... | [
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Repaglinide"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Pancreatitis"
],
[
"Pancreatitis",
"{u} (Side Effect) is caused... | Trovafloxacin (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken... |
DB00912 | DB14509 | 473 | 1,399 | [
"DDInter1581",
"DDInter1081"
] | Repaglinide | Lithium carbonate | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
473,
24,
1399
]
],
[
[
473,
63,
874
],
[
874,
23,
1399
]
],
[
[
473,
24,
1479
],
[
1479,
23,
1399
]
],
[
[
473,
24,
1385
],
[
1385,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicy... |
DB00005 | DB00987 | 1,057 | 1,224 | [
"DDInter687",
"DDInter460"
] | Etanercept | Cytarabine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Major | 2 | [
[
[
1057,
25,
1224
]
],
[
[
1057,
25,
1426
],
[
1426,
1,
1224
]
],
[
[
1057,
25,
322
],
[
322,
24,
1224
]
],
[
[
1057,
24,
987
],
[
987,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cytarabine"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azacitidine"
],
[
"Azacitidine",
"{u}... | Etanercept may lead to a major life threatening interaction when taken with Azacitidine and Azacitidine (Compound) resembles Cytarabine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when ta... |
DB00668 | DB06077 | 874 | 879 | [
"DDInter652",
"DDInter1102"
] | Epinephrine | Lumateperone | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
874,
24,
879
]
],
[
[
874,
24,
1281
],
[
1281,
63,
879
]
],
[
[
874,
63,
1645
],
[
1645,
24,
879
]
],
[
[
874,
24,
1144
],
[
1144,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and M... |
DB00314 | DB00687 | 894 | 870 | [
"DDInter288",
"DDInter747"
] | Capreomycin | Fludrocortisone | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
894,
24,
870
]
],
[
[
894,
24,
1220
],
[
1220,
40,
870
]
],
[
[
894,
21,
29232
],
[
29232,
60,
870
]
],
[
[
894,
24,
1662
],
[
1662,
... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Capreomycin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Fludrocortisone (Compound)
Capreomycin may cause a mo... |
DB00188 | DB00564 | 168 | 1,236 | [
"DDInter222",
"DDInter293"
] | Bortezomib | Carbamazepine | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Major | 2 | [
[
[
168,
25,
1236
]
],
[
[
168,
23,
307
],
[
307,
1,
1236
]
],
[
[
168,
25,
362
],
[
362,
1,
1236
]
],
[
[
168,
23,
1335
],
[
1335,
... | [
[
[
"Bortezomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carbamazepine"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modafinil"... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Carbamazepine (Compound)
Bortezomib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Bortezomib may ... |
DB00683 | DB06691 | 1,382 | 849 | [
"DDInter1212",
"DDInter1155"
] | Midazolam | Mepyramine | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1382,
24,
849
]
],
[
[
1382,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1382,
24,
272
],
[
272,
24,
849
]
],
[
[
1382,
1,
1119
],
[
1119,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Ch... |
DB00280 | DB00792 | 494 | 832 | [
"DDInter575",
"DDInter1878"
] | Disopyramide | Tripelennamine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
494,
35,
832
]
],
[
[
494,
24,
100
],
[
100,
63,
832
]
],
[
[
494,
25,
1264
],
[
1264,
63,
832
]
],
[
[
494,
40,
649
],
[
649,
1... | [
[
[
"Disopyramide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Disopyramide (Compound) resembles Tripelennamine (Compound) and
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Disopyramide may lead to a major... |
DB00202 | DB01010 | 190 | 61 | [
"DDInter1716",
"DDInter622"
] | Succinylcholine | Edrophonium | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Moderate | 1 | [
[
[
190,
24,
61
]
],
[
[
190,
6,
10558
],
[
10558,
45,
61
]
],
[
[
190,
21,
29103
],
[
29103,
60,
61
]
],
[
[
190,
24,
1011
],
[
1011,
... | [
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]
],
[
[
"Succinylcholine",
"{u} (Compound) binds {v} (Gene)",
"BCHE"
],
[
"BCHE",
"{u} (Gene) is bound by {v} (Comp... | Succinylcholine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Edrophonium (Compound)
Succinylcholine (Compound) causes Muscle contractions involuntary (Side Effect) and Muscle contractions involuntary (Side Effect) is caused by Edrophonium (Compound)
Succinylcholine may cause a moderate interaction that coul... |
DB00472 | DB00748 | 758 | 662 | [
"DDInter758",
"DDInter297"
] | Fluoxetine | Carbinoxamine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
758,
24,
662
]
],
[
[
758,
24,
28
],
[
28,
40,
662
]
],
[
[
758,
63,
1594
],
[
1594,
24,
662
]
],
[
[
758,
40,
11296
],
[
11296,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that coul... |
DB00414 | DB08820 | 590 | 1,478 | [
"DDInter16",
"DDInter997"
] | Acetohexamide | Ivacaftor | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
590,
24,
1478
]
],
[
[
590,
24,
318
],
[
318,
23,
1478
]
],
[
[
590,
63,
1230
],
[
1230,
23,
1478
]
],
[
[
590,
63,
1336
],
[
1336,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Ivacaftor
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and... |
DB01045 | DB09030 | 463 | 840 | [
"DDInter1590",
"DDInter1945"
] | Rifampicin | Vorapaxar | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
463,
25,
840
]
],
[
[
463,
25,
765
],
[
765,
24,
840
]
],
[
[
463,
25,
1017
],
[
1017,
63,
840
]
],
[
[
463,
63,
1061
],
[
1061,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hemin"
],
[
"Hemin",
"{u} may cause a ... | Rifampicin may lead to a major life threatening interaction when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Rifampicin may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction tha... |
DB00562 | DB00563 | 1,014 | 663 | [
"DDInter188",
"DDInter1174"
] | Benzthiazide | Methotrexate | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1014,
24,
663
]
],
[
[
1014,
23,
126
],
[
126,
62,
663
]
],
[
[
1014,
24,
1287
],
[
1287,
63,
663
]
],
[
[
1014,
63,
1648
],
[
1648,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
],
[
... | Benzthiazide may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Amphotericin B and Amph... |
DB00063 | DB01294 | 366 | 266 | [
"DDInter659",
"DDInter215"
] | Eptifibatide | Bismuth subsalicylate | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of [salicylic acid] linked to trivalent [bismuth cation]. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth s... | Moderate | 1 | [
[
[
366,
24,
266
]
],
[
[
366,
25,
1347
],
[
1347,
24,
266
]
],
[
[
366,
25,
235
],
[
235,
63,
266
]
],
[
[
366,
24,
578
],
[
578,
6... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bismuth subsalicylate"
]
],
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
... | Eptifibatide may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Bismuth subsalicylate
Eptifibatide may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause ... |
DB00242 | DB00307 | 1,064 | 1,101 | [
"DDInter392",
"DDInter202"
] | Cladribine | Bexarotene | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Major | 2 | [
[
[
1064,
25,
1101
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
1101
]
],
[
[
1064,
21,
28762
],
[
28762,
60,
1101
]
],
[
[
1064,
25,
597
],
[
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated b... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Bexarotene (Compound)
Cladribine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)
Cladribine may lead to a major life threatening interaction when taken with Chl... |
DB01611 | DB12500 | 1,487 | 283 | [
"DDInter893",
"DDInter714"
] | Hydroxychloroquine | Fedratinib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1487,
24,
283
]
],
[
[
1487,
25,
351
],
[
351,
23,
283
]
],
[
[
1487,
63,
122
],
[
122,
23,
283
]
],
[
[
1487,
24,
805
],
[
805,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapami... |
DB09039 | DB12364 | 1,670 | 1,421 | [
"DDInter629",
"DDInter200"
] | Eliglustat | Betrixaban | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1670,
24,
1421
]
],
[
[
1670,
64,
1091
],
[
1091,
24,
1421
]
],
[
[
1670,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
1670,
63,
529
],
[
529... | [
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Amprenavir... | Eliglustat may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause ... |
DB00827 | DB00853 | 646 | 1,686 | [
"DDInter383",
"DDInter1762"
] | Cinoxacin | Temozolomide | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Minor | 0 | [
[
[
646,
23,
1686
]
],
[
[
646,
21,
28703
],
[
28703,
60,
1686
]
],
[
[
646,
62,
970
],
[
970,
24,
1686
]
],
[
[
646,
23,
37
],
[
37,
... | [
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Temozolomide"
]
],
[
[
"Cinoxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused b... | Cinoxacin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Temozolomide (Compound)
Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Fluorouracil and Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozol... |
DB00047 | DB00104 | 176 | 966 | [
"DDInter932",
"DDInter1323"
] | Insulin glargine | Octreotide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Moderate | 1 | [
[
[
176,
24,
966
]
],
[
[
176,
24,
1154
],
[
1154,
1,
966
]
],
[
[
176,
24,
772
],
[
772,
63,
966
]
],
[
[
176,
24,
1101
],
[
1101,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide and Pasireotide (Compound) resembles Octreotide (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol may cause a moderate interact... |
DB01075 | DB04948 | 1,376 | 1,084 | [
"DDInter569",
"DDInter1083"
] | Diphenhydramine | Lofexidine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
1376,
24,
1084
]
],
[
[
1376,
63,
1617
],
[
1617,
1,
1084
]
],
[
[
1376,
24,
1311
],
[
1311,
24,
1084
]
],
[
[
1376,
63,
701
],
[
701,... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderat... |
DB00915 | DB06691 | 1,170 | 849 | [
"DDInter60",
"DDInter1155"
] | Amantadine | Mepyramine | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1170,
24,
849
]
],
[
[
1170,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1170,
24,
272
],
[
272,
24,
849
]
],
[
[
1170,
24,
103
],
[
103,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and ... |
DB06317 | DB10315 | 1,626 | 1,137 | [
"DDInter630",
"DDInter1127"
] | Elotuzumab | Measles virus vaccine live attenuated | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1626,
25,
1137
]
],
[
[
1626,
64,
581
],
[
581,
25,
1137
]
],
[
[
1626,
24,
384
],
[
384,
25,
1137
]
],
[
[
1626,
63,
1184
],
[
1184,
... | [
[
[
"Elotuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Elotuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Elotuzumab may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB00327 | DB06282 | 421 | 516 | [
"DDInter890",
"DDInter1053"
] | Hydromorphone | Levocetirizine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
421,
24,
516
]
],
[
[
421,
63,
701
],
[
701,
24,
516
]
],
[
[
421,
24,
1614
],
[
1614,
24,
516
]
],
[
[
421,
24,
407
],
[
407,
6... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Nabilone an... |
DB04946 | DB11730 | 924 | 351 | [
"DDInter907",
"DDInter1588"
] | Iloperidone | Ribociclib | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
924,
25,
351
]
],
[
[
924,
62,
112
],
[
112,
23,
351
]
],
[
[
924,
63,
222
],
[
222,
23,
351
]
],
[
[
924,
24,
283
],
[
283,
62,... | [
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Iloperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Iloperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and S... |
DB00451 | DB00841 | 542 | 532 | [
"DDInter1064",
"DDInter577"
] | Levothyroxine | Dobutamine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Moderate | 1 | [
[
[
542,
24,
532
]
],
[
[
542,
24,
817
],
[
817,
40,
532
]
],
[
[
542,
23,
1523
],
[
1523,
40,
532
]
],
[
[
542,
21,
29434
],
[
29434,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Dobutamine (Compound)
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Labetalol and Labetalol (Compound) resembles Dobutamine (Compound)
Le... |
DB00470 | DB00801 | 530 | 1,563 | [
"DDInter601",
"DDInter850"
] | Dronabinol | Halazepam | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Moderate | 1 | [
[
[
530,
24,
1563
]
],
[
[
530,
24,
686
],
[
686,
1,
1563
]
],
[
[
530,
63,
902
],
[
902,
40,
1563
]
],
[
[
530,
63,
523
],
[
523,
1... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halazepam"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Oxazepam and Oxazepam (Compound) resembles Halazepam (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Halazepam (Compound)
Dronabinol... |
DB00323 | DB00668 | 1,062 | 874 | [
"DDInter1829",
"DDInter652"
] | Tolcapone | Epinephrine | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1062,
24,
874
]
],
[
[
1062,
24,
1148
],
[
1148,
63,
874
]
],
[
[
1062,
6,
6017
],
[
6017,
45,
874
]
],
[
[
1062,
21,
28956
],
[
28956... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Tolcapone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epinephrine (Compound)
Tolcapone (Com... |
DB00175 | DB00773 | 681 | 896 | [
"DDInter1509",
"DDInter702"
] | Pravastatin | Etoposide | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
681,
24,
896
]
],
[
[
681,
6,
5912
],
[
5912,
45,
896
]
],
[
[
681,
21,
28681
],
[
28681,
60,
896
]
],
[
[
681,
24,
147
],
[
147,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Pravastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Compound)",
... | Pravastatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Etoposide (Compound)
Pravastatin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Etoposide (Compound)
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Vinbla... |
DB01088 | DB01136 | 714 | 772 | [
"DDInter908",
"DDInter305"
] | Iloprost | Carvedilol | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
714,
24,
772
]
],
[
[
714,
24,
578
],
[
578,
62,
772
]
],
[
[
714,
63,
1479
],
[
1479,
23,
772
]
],
[
[
714,
63,
702
],
[
702,
2... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Carvedilol
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Ac... |
DB00348 | DB12267 | 254 | 1,476 | [
"DDInter1300",
"DDInter233"
] | Nitisinone | Brigatinib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
254,
24,
1476
]
],
[
[
254,
24,
951
],
[
951,
24,
1476
]
],
[
[
254,
24,
1598
],
[
1598,
63,
1476
]
],
[
[
254,
63,
245
],
[
245,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Ta... |
DB05679 | DB11627 | 1,683 | 1,367 | [
"DDInter1907",
"DDInter860"
] | Ustekinumab | Hepatitis B Vaccine (Recombinant) | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1683,
24,
1367
]
],
[
[
1683,
63,
1083
],
[
1083,
24,
1367
]
],
[
[
1683,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
1683,
24,
1480
],
[
14... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tr... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Ustekinumab may lead to a major life threatening interaction when taken with Cladrib... |
DB00307 | DB00773 | 1,101 | 896 | [
"DDInter202",
"DDInter702"
] | Bexarotene | Etoposide | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
1101,
24,
896
]
],
[
[
1101,
5,
11555
],
[
11555,
44,
896
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
896
]
],
[
[
1101,
21,
28681
],
[
2868... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Bexarotene",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Bexarotene (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Etoposide (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etoposide (Compound)
Bexarotene (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is cau... |
DB00374 | DB11703 | 1,061 | 405 | [
"DDInter1852",
"DDInter9"
] | Treprostinil | Acalabrutinib | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1061,
25,
405
]
],
[
[
1061,
24,
383
],
[
383,
24,
405
]
],
[
[
1061,
63,
1230
],
[
1230,
24,
405
]
],
[
[
1061,
24,
738
],
[
738,
... | [
[
[
"Treprostinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken... |
DB01229 | DB09074 | 973 | 1,362 | [
"DDInter1377",
"DDInter1327"
] | Paclitaxel | Olaparib | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
973,
24,
1362
]
],
[
[
973,
63,
896
],
[
896,
24,
1362
]
],
[
[
973,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
973,
24,
1619
],
[
1619,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinum... |
DB00562 | DB01050 | 1,014 | 848 | [
"DDInter188",
"DDInter900"
] | Benzthiazide | Ibuprofen | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1014,
24,
848
]
],
[
[
1014,
24,
1053
],
[
1053,
1,
848
]
],
[
[
1014,
24,
286
],
[
286,
62,
848
]
],
[
[
1014,
40,
178
],
[
178,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor ... |
DB00619 | DB11952 | 1,419 | 800 | [
"DDInter909",
"DDInter612"
] | Imatinib | Duvelisib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1419,
24,
800
]
],
[
[
1419,
24,
466
],
[
466,
62,
800
]
],
[
[
1419,
23,
222
],
[
222,
23,
800
]
],
[
[
1419,
24,
310
],
[
310,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Imatinib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramin... |
DB04868 | DB06016 | 478 | 1,508 | [
"DDInter1293",
"DDInter300"
] | Nilotinib | Cariprazine | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
478,
24,
1508
]
],
[
[
478,
25,
1593
],
[
1593,
63,
1508
]
],
[
[
478,
64,
600
],
[
600,
24,
1508
]
],
[
[
478,
24,
761
],
[
761,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotinib"... | Nilotinib may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Nilotinib may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate int... |
DB00222 | DB01069 | 245 | 401 | [
"DDInter825",
"DDInter1533"
] | Glimepiride | Promethazine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
245,
24,
401
]
],
[
[
245,
24,
146
],
[
146,
24,
401
]
],
[
[
245,
24,
1264
],
[
1264,
63,
401
]
],
[
[
245,
6,
6017
],
[
6017,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and D... |
DB09118 | DB11828 | 1,580 | 1,406 | [
"DDInter1711",
"DDInter1281"
] | Stiripentol | Neratinib | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
1580,
25,
1406
]
],
[
[
1580,
64,
1135
],
[
1135,
23,
1406
]
],
[
[
1580,
63,
392
],
[
392,
24,
1406
]
],
[
[
1580,
24,
1499
],
[
1499... | [
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ma... | Stiripentol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a mod... |
DB00889 | DB06402 | 1,133 | 1,079 | [
"DDInter840",
"DDInter1756"
] | Granisetron | Telavancin | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
1133,
24,
1079
]
],
[
[
1133,
21,
28680
],
[
28680,
60,
1079
]
],
[
[
1133,
23,
112
],
[
112,
23,
1079
]
],
[
[
1133,
24,
657
],
[
657... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Granisetron",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v... | Granisetron (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telavancin (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
Gr... |
DB01114 | DB01181 | 272 | 1,532 | [
"DDInter362",
"DDInter906"
] | Chlorpheniramine | Ifosfamide | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
272,
24,
1532
]
],
[
[
272,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
272,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
272,
63,
684
],
[
684,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} ... | Chlorpheniramine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Chlorpheniramine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB06317 | DB15091 | 1,626 | 676 | [
"DDInter630",
"DDInter1901"
] | Elotuzumab | Upadacitinib | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1626,
25,
676
]
],
[
[
1626,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1626,
63,
248
],
[
248,
24,
676
]
],
[
[
1626,
63,
1184
],
[
1184,
... | [
[
[
"Elotuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir ... |
DB00948 | DB09293 | 1,681 | 116 | [
"DDInter1207",
"DDInter954"
] | Mezlocillin | Iodide I-131 | Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1681,
24,
116
]
],
[
[
1681,
40,
1249
],
[
1249,
24,
116
]
],
[
[
1681,
63,
126
],
[
126,
24,
116
]
],
[
[
1681,
40,
1249
],
[
1249,
... | [
[
[
"Mezlocillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Mezlocillin",
"{u} (Compound) resembles {v} (Compound)",
"Nafcillin"
],
[
"Nafcillin",
"{u} may cause a moder... | Mezlocillin (Compound) resembles Nafcillin (Compound) and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Mezlocillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could e... |
DB06626 | DB14730 | 263 | 1,412 | [
"DDInter147",
"DDInter264"
] | Axitinib | Calaspargase pegol | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
263,
24,
1412
]
],
[
[
263,
24,
159
],
[
159,
24,
1412
]
],
[
[
263,
63,
322
],
[
322,
24,
1412
]
],
[
[
263,
25,
384
],
[
384,
... | [
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin ... |
DB00220 | DB01234 | 798 | 1,220 | [
"DDInter1276",
"DDInter513"
] | Nelfinavir | Dexamethasone | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
798,
24,
1220
]
],
[
[
798,
24,
870
],
[
870,
1,
1220
]
],
[
[
798,
25,
175
],
[
175,
40,
1220
]
],
[
[
798,
63,
1351
],
[
1351,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Nelfinavir may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethasone (Com... |
DB00762 | DB10276 | 613 | 1,624 | [
"DDInter973",
"DDInter1623"
] | Irinotecan | Rotavirus vaccine | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
613,
25,
1624
]
],
[
[
613,
25,
770
],
[
770,
25,
1624
]
],
[
[
613,
63,
58
],
[
58,
25,
1624
]
],
[
[
613,
24,
869
],
[
869,
25... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
],
[
"Thalidomide",
... | Irinotecan may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a major life threatening interaction when taken with Rotavirus vaccine
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may lead to a majo... |
DB00754 | DB09278 | 157 | 852 | [
"DDInter696",
"DDInter24"
] | Ethotoin | Activated charcoal | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
157,
24,
852
]
],
[
[
157,
1,
697
],
[
697,
24,
852
]
],
[
[
157,
63,
964
],
[
964,
24,
852
]
],
[
[
157,
24,
1264
],
[
1264,
24... | [
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Ethotoin",
"{u} (Compound) resembles {v} (Compound)",
"Phenobarbital"
],
[
"Phenobarbital",
"{u} may cause... | Ethotoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a moderate interactio... |
DB01118 | DB06663 | 33 | 1,154 | [
"DDInter76",
"DDInter1398"
] | Amiodarone | Pasireotide | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
33,
25,
1154
]
],
[
[
33,
63,
966
],
[
966,
40,
1154
]
],
[
[
33,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
33,
63,
112
],
[
112,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
"Octreotid... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Amiodarone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Amiodarone may cause a moderate ... |
DB01087 | DB01591 | 1,520 | 667 | [
"DDInter1520",
"DDInter1696"
] | Primaquine | Solifenacin | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
1520,
24,
667
]
],
[
[
1520,
6,
8374
],
[
8374,
45,
667
]
],
[
[
1520,
21,
28722
],
[
28722,
60,
667
]
],
[
[
1520,
62,
112
],
[
112,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Primaquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Primaquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Solifenacin (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metroni... |
DB00635 | DB00808 | 1,573 | 1,605 | [
"DDInter1515",
"DDInter916"
] | Prednisone | Indapamide | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
1573,
24,
1605
]
],
[
[
1573,
63,
811
],
[
811,
1,
1605
]
],
[
[
1573,
24,
1335
],
[
1335,
40,
1605
]
],
[
[
1573,
6,
8374
],
[
8374,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Indapamide (Comp... |
DB00056 | DB00445 | 816 | 322 | [
"DDInter814",
"DDInter655"
] | Gemtuzumab ozogamicin | Epirubicin | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
816,
24,
322
]
],
[
[
816,
23,
646
],
[
646,
62,
322
]
],
[
[
816,
24,
748
],
[
748,
63,
322
]
],
[
[
816,
24,
482
],
[
482,
24,... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxac... | Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin and Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Anthr... |
DB00313 | DB06723 | 556 | 115 | [
"DDInter1913",
"DDInter58"
] | Valproic acid | Aluminum hydroxide | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
556,
23,
115
]
],
[
[
556,
21,
28643
],
[
28643,
60,
115
]
],
[
[
556,
24,
401
],
[
401,
23,
115
]
],
[
[
556,
23,
752
],
[
752,
... | [
[
[
"Valproic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Valproic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Eff... | Valproic acid (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when ta... |
DB00457 | DB06292 | 1,205 | 549 | [
"DDInter1511",
"DDInter474"
] | Prazosin | Dapagliflozin | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1205,
24,
549
]
],
[
[
1205,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1205,
6,
9842
],
[
9842,
45,
549
]
],
[
[
1205,
21,
28882
],
[
28882... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
... | Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Prazosin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dapagliflozin (Compound)
Prazosin (Compound) causes Body temperature increased (Sid... |
DB00393 | DB01050 | 854 | 848 | [
"DDInter1295",
"DDInter900"
] | Nimodipine | Ibuprofen | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
854,
24,
848
]
],
[
[
854,
24,
1053
],
[
1053,
1,
848
]
],
[
[
854,
21,
28640
],
[
28640,
60,
848
]
],
[
[
854,
24,
752
],
[
752,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
[
... | Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Nimodipine (Compound) causes Depression (Side Effect) and Depression (Side Effect) is caused by Ibuprofen (Compound)
Nimodipine may cause a moderate interact... |
DB01234 | DB11071 | 1,220 | 1,004 | [
"DDInter513",
"DDInter1449"
] | Dexamethasone | Phenyl salicylate | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1220,
24,
1004
]
],
[
[
1220,
23,
771
],
[
771,
62,
1004
]
],
[
[
1220,
63,
1411
],
[
1411,
24,
1004
]
],
[
[
1220,
40,
1573
],
[
1573... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Dexamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Tolbut... |
DB00991 | DB09268 | 97 | 1,662 | [
"DDInter1358",
"DDInter1464"
] | Oxaprozin | Picosulfuric acid | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
97,
24,
1662
]
],
[
[
97,
23,
16
],
[
16,
23,
1662
]
],
[
[
97,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
97,
63,
91
],
[
91,
24,
... | [
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Oxaprozin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
],
... | Oxaprozin may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Oxaprozin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may... |
DB00500 | DB09268 | 24 | 1,662 | [
"DDInter1831",
"DDInter1464"
] | Tolmetin | Picosulfuric acid | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
24,
24,
1662
]
],
[
[
24,
23,
16
],
[
16,
23,
1662
]
],
[
[
24,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
24,
24,
91
],
[
91,
24,
... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Tolmetin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
],
[
... | Tolmetin may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Tolmetin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may c... |
DB01227 | DB09268 | 1,301 | 1,662 | [
"DDInter1043",
"DDInter1464"
] | Levacetylmethadol | Picosulfuric acid | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
1301,
25,
1662
]
],
[
[
1301,
25,
484
],
[
484,
63,
1662
]
],
[
[
1301,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1301,
64,
597
],
[
597,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"Ent... | Levacetylmethadol may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Levacetylmethadol may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantini... |
DB01222 | DB14409 | 617 | 1,129 | [
"DDInter246",
"DDInter867"
] | Budesonide | Human adenovirus e serotype 4 strain cl-68578 antigen | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
617,
24,
1129
]
],
[
[
617,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
617,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
617,
40,
251
],
[
251,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Budesonide",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Budesonide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Budesonide may cause a moderate interaction that could exacerbate diseases when take... |
DB01236 | DB11901 | 679 | 913 | [
"DDInter1664",
"DDInter107"
] | Sevoflurane | Apalutamide | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
679,
24,
913
]
],
[
[
679,
62,
112
],
[
112,
23,
913
]
],
[
[
679,
63,
600
],
[
600,
24,
913
]
],
[
[
679,
24,
28
],
[
28,
24,
... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Sevoflurane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB00065 | DB00277 | 581 | 1,031 | [
"DDInter923",
"DDInter1791"
] | Infliximab | Theophylline | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Moderate | 1 | [
[
[
581,
24,
1031
]
],
[
[
581,
24,
523
],
[
523,
62,
1031
]
],
[
[
581,
25,
1096
],
[
1096,
62,
1031
]
],
[
[
581,
24,
1072
],
[
1072,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline
Infliximab may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic a... |
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