drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00992 | DB01165 | 842 | 1,539 | [
"DDInter1182",
"DDInter1325"
] | Methyl aminolevulinate (topical) | Ofloxacin | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
842,
24,
1539
]
],
[
[
842,
63,
1467
],
[
1467,
1,
1539
]
],
[
[
842,
24,
945
],
[
945,
40,
1539
]
],
[
[
842,
24,
246
],
[
246,
... | [
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enox... | Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin
Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Methyl aminolevulinate may cause a moder... |
DB01177 | DB12035 | 77 | 943 | [
"DDInter904",
"DDInter1641"
] | Idarubicin | Sarecycline | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
77,
24,
943
]
],
[
[
77,
63,
1181
],
[
1181,
24,
943
]
],
[
[
77,
24,
1670
],
[
1670,
24,
943
]
],
[
[
77,
24,
1619
],
[
1619,
6... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eli... |
DB00270 | DB00741 | 1,428 | 167 | [
"DDInter993",
"DDInter885"
] | Isradipine | Hydrocortisone | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1428,
24,
167
]
],
[
[
1428,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1428,
24,
870
],
[
870,
1,
167
]
],
[
[
1428,
6,
8374
],
[
8374,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hy... |
DB00694 | DB01115 | 51 | 336 | [
"DDInter485",
"DDInter1291"
] | Daunorubicin | Nifedipine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
51,
24,
336
]
],
[
[
51,
24,
409
],
[
409,
1,
336
]
],
[
[
51,
6,
7950
],
[
7950,
45,
336
]
],
[
[
51,
18,
7933
],
[
7933,
46,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Nifedipine (Compound)
Daunorubicin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound)
Daunorubicin (Compound) downregulates DDX42 (Gene) and DDX42 (... |
DB00682 | DB01155 | 126 | 872 | [
"DDInter1951",
"DDInter813"
] | Warfarin | Gemifloxacin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Major | 2 | [
[
[
126,
25,
872
]
],
[
[
126,
25,
739
],
[
739,
1,
872
]
],
[
[
126,
64,
1467
],
[
1467,
1,
872
]
],
[
[
126,
25,
945
],
[
945,
40,... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u}... | Warfarin may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Warfarin may lead to a major life threatening interaction when taken with Enoxacin and Enoxacin (Compound) resembles Gemifloxacin (Compound)
Warfarin may lead to a major l... |
DB00816 | DB08918 | 1,674 | 41 | [
"DDInter1346",
"DDInter1059"
] | Orciprenaline | Levomilnacipran | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1674,
24,
41
]
],
[
[
1674,
24,
901
],
[
901,
40,
41
]
],
[
[
1674,
21,
28975
],
[
28975,
60,
41
]
],
[
[
1674,
25,
1618
],
[
1618,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Orciprenaline (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Levomilnacipran (Compound)
Orciprenaline may lead to a ma... |
DB01101 | DB01177 | 60 | 77 | [
"DDInter285",
"DDInter904"
] | Capecitabine | Idarubicin | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
60,
24,
77
]
],
[
[
60,
5,
11579
],
[
11579,
44,
77
]
],
[
[
60,
6,
6017
],
[
6017,
45,
77
]
],
[
[
60,
7,
6952
],
[
6952,
46,
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Capecitabine",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is ... | Capecitabine (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Idarubicin (Compound)
Capecitabine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Capecitabine (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compoun... |
DB00705 | DB00731 | 441 | 1,144 | [
"DDInter496",
"DDInter1269"
] | Delavirdine | Nateglinide | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
441,
24,
1144
]
],
[
[
441,
63,
168
],
[
168,
24,
1144
]
],
[
[
441,
6,
6799
],
[
6799,
45,
1144
]
],
[
[
441,
21,
28787
],
[
28787,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Delavirdine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Nateglinide (Compound)
Delavirdine (C... |
DB00214 | DB09156 | 1,028 | 777 | [
"DDInter1836",
"DDInter964"
] | Torasemide | Iopromide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
1028,
24,
777
]
],
[
[
1028,
63,
1648
],
[
1648,
24,
777
]
],
[
[
1028,
24,
1512
],
[
1512,
25,
777
]
],
[
[
1028,
25,
1132
],
[
1132,... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclo... |
DB09073 | DB14443 | 951 | 987 | [
"DDInter1379",
"DDInter1931"
] | Palbociclib | Vibrio cholerae CVD 103-HgR strain live antigen | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
951,
24,
987
]
],
[
[
951,
63,
1220
],
[
1220,
24,
987
]
],
[
[
951,
24,
351
],
[
351,
24,
987
]
],
[
[
951,
64,
384
],
[
384,
2... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Palbociclib may cause a moderate interaction that could exacerbate d... |
DB00065 | DB08908 | 581 | 713 | [
"DDInter923",
"DDInter564"
] | Infliximab | Dimethyl fumarate | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Major | 2 | [
[
[
581,
25,
713
]
],
[
[
581,
24,
996
],
[
996,
24,
713
]
],
[
[
581,
25,
1083
],
[
1083,
24,
713
]
],
[
[
581,
25,
725
],
[
725,
6... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
],
[
"Be... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Infliximab may lead to a major life threatening interaction when taken with Trifluridine and Trifluridi... |
DB00087 | DB01087 | 599 | 1,520 | [
"DDInter41",
"DDInter1520"
] | Alemtuzumab | Primaquine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
599,
24,
1520
]
],
[
[
599,
24,
1342
],
[
1342,
63,
1520
]
],
[
[
599,
24,
322
],
[
322,
24,
1520
]
],
[
[
599,
25,
1292
],
[
1292,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Primaquine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epir... |
DB06702 | DB12267 | 573 | 1,476 | [
"DDInter731",
"DDInter233"
] | Fesoterodine | Brigatinib | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
573,
24,
1476
]
],
[
[
573,
63,
918
],
[
918,
24,
1476
]
],
[
[
573,
40,
494
],
[
494,
24,
1476
]
],
[
[
573,
24,
982
],
[
982,
... | [
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Fesoterodine (Compound) resembles Disopyramide (Compound) and Disopyramide may cause a moderate interactio... |
DB00836 | DB00924 | 543 | 1,405 | [
"DDInter1088",
"DDInter454"
] | Loperamide | Cyclobenzaprine | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
543,
24,
1405
]
],
[
[
543,
40,
649
],
[
649,
63,
1405
]
],
[
[
543,
63,
1302
],
[
1302,
1,
1405
]
],
[
[
543,
24,
358
],
[
358,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Loperamide",
"{u} (Compound) resembles {v} (Compound)",
"Clofedanol"
],
[
"Clofedanol",
"{u} may cause a mo... | Loperamide (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Cyclobenzap... |
DB00278 | DB01088 | 291 | 714 | [
"DDInter117",
"DDInter908"
] | Argatroban | Iloprost | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
291,
24,
714
]
],
[
[
291,
23,
539
],
[
539,
62,
714
]
],
[
[
291,
24,
383
],
[
383,
24,
714
]
],
[
[
291,
64,
1432
],
[
1432,
2... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Argatroban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"C... | Argatroban may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Iloprost
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentos... |
DB11901 | DB12329 | 913 | 464 | [
"DDInter107",
"DDInter660"
] | Apalutamide | Eravacycline | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive aerobic, and facultative bacteria. This includes most of those bacteria resistant to cephalosporins, fluoroquin... | Major | 2 | [
[
[
913,
25,
464
]
],
[
[
913,
63,
609
],
[
609,
23,
464
]
],
[
[
913,
64,
384
],
[
384,
23,
464
]
],
[
[
913,
63,
1096
],
[
1096,
2... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eravacycline"
]
],
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
[
"Cl... | Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Eravacycline
Apalutamide may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib ... |
DB06717 | DB08875 | 875 | 1,618 | [
"DDInter778",
"DDInter262"
] | Fosaprepitant | Cabozantinib | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
875,
24,
1618
]
],
[
[
875,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
875,
40,
723
],
[
723,
24,
1618
]
],
[
[
875,
24,
384
],
[
384,
... | [
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Fosaprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Nal... | Fosaprepitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Fosaprepitant (Compound) resembles Aprepitant (Compound) and Aprepitant may cause a moderate interaction that could exacerbate... |
DB00532 | DB00860 | 208 | 891 | [
"DDInter1152",
"DDInter1513"
] | Mephenytoin | Prednisolone | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
208,
24,
891
]
],
[
[
208,
24,
175
],
[
175,
40,
891
]
],
[
[
208,
24,
167
],
[
167,
1,
891
]
],
[
[
208,
63,
251
],
[
251,
1,
... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Pred... |
DB00476 | DB01129 | 109 | 379 | [
"DDInter608",
"DDInter1559"
] | Duloxetine | Rabeprazole | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Minor | 0 | [
[
[
109,
23,
379
]
],
[
[
109,
62,
1215
],
[
1215,
40,
379
]
],
[
[
109,
23,
660
],
[
660,
1,
379
]
],
[
[
109,
62,
837
],
[
837,
1,... | [
[
[
"Duloxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rabeprazole"
]
],
[
[
"Duloxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lansoprazole"
],
[
... | Duloxetine may cause a minor interaction that can limit clinical effects when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (Comp... |
DB00526 | DB00877 | 1,555 | 629 | [
"DDInter1355",
"DDInter1678"
] | Oxaliplatin | Sirolimus | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1555,
24,
629
]
],
[
[
1555,
63,
1461
],
[
1461,
23,
629
]
],
[
[
1555,
24,
419
],
[
419,
63,
629
]
],
[
[
1555,
25,
1301
],
[
1301,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sirolimus
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Halothane and Halothane ... |
DB00450 | DB09054 | 78 | 384 | [
"DDInter603",
"DDInter905"
] | Droperidol | Idelalisib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
78,
24,
384
]
],
[
[
78,
24,
222
],
[
222,
23,
384
]
],
[
[
78,
25,
1618
],
[
1618,
24,
384
]
],
[
[
78,
64,
600
],
[
600,
24,
... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Droperidol may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may ca... |
DB00810 | DB01114 | 456 | 272 | [
"DDInter211",
"DDInter362"
] | Biperiden | Chlorpheniramine | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
456,
24,
272
]
],
[
[
456,
1,
11268
],
[
11268,
1,
272
]
],
[
[
456,
24,
849
],
[
849,
63,
272
]
],
[
[
456,
63,
128
],
[
128,
2... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Biperiden",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Compound) ... | Biperiden (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Chlorpheniramine (Compound)
Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chl... |
DB01246 | DB09038 | 820 | 1,450 | [
"DDInter45",
"DDInter636"
] | Alimemazine | Empagliflozin | A phenothiazine derivative that is used as an antipruritic. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
820,
24,
1450
]
],
[
[
820,
63,
461
],
[
461,
24,
1450
]
],
[
[
820,
24,
659
],
[
659,
63,
1450
]
],
[
[
820,
24,
911
],
[
911,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilante... |
DB11003 | DB11760 | 748 | 119 | [
"DDInter100",
"DDInter1742"
] | Anthrax vaccine | Talazoparib | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
748,
24,
119
]
],
[
[
748,
63,
66
],
[
66,
24,
119
]
],
[
[
748,
24,
351
],
[
351,
24,
119
]
],
[
[
748,
24,
1619
],
[
1619,
63,... | [
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
... | Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib... |
DB00514 | DB09065 | 506 | 760 | [
"DDInter527",
"DDInter424"
] | Dextromethorphan | Cobicistat | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
506,
24,
760
]
],
[
[
506,
24,
1627
],
[
1627,
23,
760
]
],
[
[
506,
64,
1230
],
[
1230,
23,
760
]
],
[
[
506,
25,
318
],
[
318,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Dextromethorphan may lead to a major life threatening interaction when taken with Citalopram and Citalopra... |
DB01215 | DB08938 | 1,418 | 1,384 | [
"DDInter677",
"DDInter1112"
] | Estazolam | Magaldrate | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
1418,
23,
1384
]
],
[
[
1418,
63,
752
],
[
752,
23,
1384
]
],
[
[
1418,
40,
1119
],
[
1119,
23,
1384
]
],
[
[
1418,
1,
686
],
[
686,
... | [
[
[
"Estazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[
... | Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Estazolam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide may cause a minor interaction that ... |
DB01227 | DB09241 | 1,301 | 1,629 | [
"DDInter1043",
"DDInter1186"
] | Levacetylmethadol | Methylene blue | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1301,
25,
1629
]
],
[
[
1301,
64,
1148
],
[
1148,
24,
1629
]
],
[
[
1301,
24,
659
],
[
659,
24,
1629
]
],
[
[
1301,
63,
455
],
[
455,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
],
[
"Isopr... | Levacetylmethadol may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and... |
DB01009 | DB08896 | 935 | 292 | [
"DDInter1009",
"DDInter1576"
] | Ketoprofen | Regorafenib | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
935,
25,
292
]
],
[
[
935,
6,
6017
],
[
6017,
45,
292
]
],
[
[
935,
21,
28890
],
[
28890,
60,
292
]
],
[
[
935,
63,
1560
],
[
1560,
... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Ketoprofen",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Regora... | Ketoprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Ketoprofen (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound)
Ketoprofen may cause a moderate interaction that could exacerbate diseases when take... |
DB00641 | DB01232 | 467 | 1,327 | [
"DDInter1675",
"DDInter1640"
] | Simvastatin | Saquinavir | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
467,
25,
1327
]
],
[
[
467,
64,
798
],
[
798,
40,
1327
]
],
[
[
467,
25,
915
],
[
915,
40,
1327
]
],
[
[
467,
6,
15333
],
[
15333,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",
"{u}... | Simvastatin may lead to a major life threatening interaction when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Simvastatin may lead to a major life threatening interaction when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
Simvastatin (Compound) binds... |
DB00661 | DB09039 | 122 | 1,670 | [
"DDInter1928",
"DDInter629"
] | Verapamil | Eliglustat | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
122,
25,
1670
]
],
[
[
122,
25,
1135
],
[
1135,
62,
1670
]
],
[
[
122,
24,
1409
],
[
1409,
24,
1670
]
],
[
[
122,
24,
1499
],
[
1499,
... | [
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may c... | Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a moderate... |
DB00795 | DB00877 | 50 | 629 | [
"DDInter1725",
"DDInter1678"
] | Sulfasalazine | Sirolimus | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
50,
25,
629
]
],
[
[
50,
6,
15333
],
[
15333,
45,
629
]
],
[
[
50,
6,
2067
],
[
2067,
46,
629
]
],
[
[
50,
18,
5415
],
[
5415,
4... | [
[
[
"Sulfasalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Sulfasalazine",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B1"
],
[
"SLCO1B1",
"{u} (Gene) is bound by {v} (Compound)",
"... | Sulfasalazine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Sirolimus (Compound)
Sulfasalazine (Compound) binds IKBKB (Gene) and IKBKB (Gene) is upregulated by Sirolimus (Compound)
Sulfasalazine (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Sirolimus (Compound)
Sulfasalazin... |
DB00902 | DB08897 | 104 | 1,429 | [
"DDInter1168",
"DDInter22"
] | Methdilazine | Aclidinium | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
104,
24,
1429
]
],
[
[
104,
63,
352
],
[
352,
24,
1429
]
],
[
[
104,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
104,
1,
537
],
[
537,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepen... |
DB00833 | DB09104 | 1,305 | 286 | [
"DDInter309",
"DDInter1118"
] | Cefaclor | Magnesium hydroxide | Semisynthetic, broad-spectrum antibiotic derivative of cephalexin. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1305,
24,
286
]
],
[
[
1305,
24,
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],
[
1096,
24,
286
]
],
[
[
1305,
1,
1024
],
[
1024,
24,
286
]
],
[
[
1305,
40,
339
],
[
339,
... | [
[
[
"Cefaclor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Cefaclor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Cefaclor may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Cefaclor (Compound) resembles Cefpodoxime (Compound) and Cefpodoxime may cause a moderate i... |
DB00501 | DB06700 | 752 | 643 | [
"DDInter380",
"DDInter511"
] | Cimetidine | Desvenlafaxine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Minor | 0 | [
[
[
752,
23,
643
]
],
[
[
752,
62,
1100
],
[
1100,
1,
643
]
],
[
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8374
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[
8374,
45,
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]
],
[
[
752,
21,
28809
],
[
28809,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Venlafaxine"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Desvenlafaxine (Compound)
Cimetidine (Compound) causes Diarrhoea (Side Effect) and D... |
DB00254 | DB05528 | 964 | 1,070 | [
"DDInter598",
"DDInter1228"
] | Doxycycline | Mipomersen | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
964,
25,
1070
]
],
[
[
964,
25,
1517
],
[
1517,
25,
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[
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964,
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384
],
[
384,
64,
1070
]
],
[
[
964,
40,
1620
],
[
1620,
... | [
[
[
"Doxycycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Doxycycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isotretinoin"
],
[
"Isotretinoin",
... | Doxycycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Mipomersen
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may lead to a major... |
DB00586 | DB00880 | 1,512 | 359 | [
"DDInter537",
"DDInter360"
] | Diclofenac | Chlorothiazide | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
1512,
24,
359
]
],
[
[
1512,
24,
1577
],
[
1577,
1,
359
]
],
[
[
1512,
63,
1014
],
[
1014,
1,
359
]
],
[
[
1512,
6,
10612
],
[
10612,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resemble... |
DB01619 | DB09061 | 830 | 1,627 | [
"DDInter1441",
"DDInter284"
] | Phenindamine | Cannabidiol | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
830,
24,
1627
]
],
[
[
830,
63,
1594
],
[
1594,
24,
1627
]
],
[
[
830,
24,
516
],
[
516,
24,
1627
]
],
[
[
830,
40,
104
],
[
104,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine a... |
DB00734 | DB11130 | 1,664 | 407 | [
"DDInter1605",
"DDInter1344"
] | Risperidone | Opium | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1664,
24,
407
]
],
[
[
1664,
24,
662
],
[
662,
24,
407
]
],
[
[
1664,
63,
1233
],
[
1233,
24,
407
]
],
[
[
1664,
64,
475
],
[
475,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine and T... |
DB00312 | DB00916 | 1,023 | 112 | [
"DDInter1423",
"DDInter1202"
] | Pentobarbital | Metronidazole | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
1023,
24,
112
]
],
[
[
1023,
24,
458
],
[
458,
40,
112
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
112
]
],
[
[
1023,
21,
28789
],
[
28789,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound)
Pentobarbital (Compound) causes Loss of consciousness ... |
DB01619 | DB09034 | 830 | 1,313 | [
"DDInter1441",
"DDInter1733"
] | Phenindamine | Suvorexant | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
830,
24,
1313
]
],
[
[
830,
63,
530
],
[
530,
24,
1313
]
],
[
[
830,
24,
516
],
[
516,
24,
1313
]
],
[
[
830,
24,
1609
],
[
1609,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Suvorexant
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine an... |
DB00615 | DB08865 | 690 | 1,593 | [
"DDInter1589",
"DDInter448"
] | Rifabutin | Crizotinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
690,
25,
1593
]
],
[
[
690,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
690,
7,
3727
],
[
3727,
46,
1593
]
],
[
[
690,
18,
2183
],
[
2183,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotini... | Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Rifabutin (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Crizotinib (Compound)
Rifabutin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Crizotinib (Compound)
Rifabutin (Compound) ... |
DB00242 | DB00970 | 1,064 | 0 | [
"DDInter392",
"DDInter466"
] | Cladribine | Dactinomycin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Major | 2 | [
[
[
1064,
25,
0
]
],
[
[
1064,
6,
17404
],
[
17404,
45,
0
]
],
[
[
1064,
7,
18110
],
[
18110,
46,
0
]
],
[
[
1064,
18,
2183
],
[
2183,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dactinomycin"
]
],
[
[
"Cladribine",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
"Dactino... | Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dactinomycin (Compound)
Cladribine (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Dactinomycin (Compound)
Cladribine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dactinomycin (Compound)
... |
DB00888 | DB14443 | 1,001 | 987 | [
"DDInter1133",
"DDInter1931"
] | Mechlorethamine | Vibrio cholerae CVD 103-HgR strain live antigen | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1001,
24,
987
]
],
[
[
1001,
63,
141
],
[
141,
24,
987
]
],
[
[
1001,
24,
1224
],
[
1224,
24,
987
]
],
[
[
1001,
64,
581
],
[
581,
... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when take... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Mechlorethamine may cause a moderate interaction that could exacerba... |
DB00005 | DB00361 | 1,057 | 134 | [
"DDInter687",
"DDInter1939"
] | Etanercept | Vinorelbine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Major | 2 | [
[
[
1057,
25,
134
]
],
[
[
1057,
25,
147
],
[
147,
63,
134
]
],
[
[
1057,
24,
151
],
[
151,
63,
134
]
],
[
[
1057,
25,
1101
],
[
1101,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinorelbine"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinblastine"
],
[
"Vinblastine",
"{u... | Etanercept may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/... |
DB00615 | DB08816 | 690 | 578 | [
"DDInter1589",
"DDInter1802"
] | Rifabutin | Ticagrelor | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
690,
24,
578
]
],
[
[
690,
6,
8374
],
[
8374,
45,
578
]
],
[
[
690,
21,
28646
],
[
28646,
60,
578
]
],
[
[
690,
24,
1135
],
[
1135,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Rifabutin (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Rifabutin may cause a mode... |
DB01142 | DB01221 | 1,264 | 1,190 | [
"DDInter593",
"DDInter1007"
] | Doxepin | Ketamine | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
1264,
24,
1190
]
],
[
[
1264,
6,
8374
],
[
8374,
45,
1190
]
],
[
[
1264,
21,
28642
],
[
28642,
60,
1190
]
],
[
[
1264,
24,
649
],
[
64... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"... | Doxepin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketamine (Compound)
Doxepin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Ketamine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a mo... |
DB08870 | DB09038 | 850 | 1,450 | [
"DDInter228",
"DDInter636"
] | Brentuximab vedotin | Empagliflozin | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
850,
24,
1450
]
],
[
[
850,
63,
1551
],
[
1551,
24,
1450
]
],
[
[
850,
24,
1017
],
[
1017,
63,
1450
]
],
[
[
850,
25,
1510
],
[
1510,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00379 | DB11569 | 143 | 1,093 | [
"DDInter1206",
"DDInter1003"
] | Mexiletine | Ixekizumab | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
143,
24,
1093
]
],
[
[
143,
63,
608
],
[
608,
24,
1093
]
],
[
[
143,
24,
1683
],
[
1683,
24,
1093
]
],
[
[
143,
64,
1031
],
[
1031,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekin... |
DB00662 | DB11859 | 717 | 418 | [
"DDInter1873",
"DDInter230"
] | Trimethobenzamide | Brexanolone | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like various other types of depr... | Moderate | 1 | [
[
[
717,
24,
418
]
],
[
[
717,
24,
820
],
[
820,
24,
418
]
],
[
[
717,
63,
1233
],
[
1233,
24,
418
]
],
[
[
717,
24,
820
],
[
820,
6... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexanolone"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Brexanolone
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Trip... |
DB00209 | DB00562 | 352 | 1,014 | [
"DDInter1886",
"DDInter188"
] | Trospium | Benzthiazide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Minor | 0 | [
[
[
352,
23,
1014
]
],
[
[
352,
23,
811
],
[
811,
40,
1014
]
],
[
[
352,
23,
674
],
[
674,
1,
1014
]
],
[
[
352,
35,
1192
],
[
1192,
... | [
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Benzthiazide"
]
],
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
],
[
"M... | Trospium may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resembles Benzthiazide (Compound)
Trospium may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Benzthiazide... |
DB01124 | DB06016 | 1,411 | 1,508 | [
"DDInter1828",
"DDInter300"
] | Tolbutamide | Cariprazine | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1411,
24,
1508
]
],
[
[
1411,
64,
600
],
[
600,
24,
1508
]
],
[
[
1411,
63,
176
],
[
176,
24,
1508
]
],
[
[
1411,
24,
1450
],
[
1450,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Tolbutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Flucon... | Tolbutamide may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin gl... |
DB00352 | DB13179 | 482 | 68 | [
"DDInter1814",
"DDInter1882"
] | Tioguanine | Troleandomycin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
482,
24,
68
]
],
[
[
482,
63,
1101
],
[
1101,
23,
68
]
],
[
[
482,
24,
1374
],
[
1374,
23,
68
]
],
[
[
482,
24,
267
],
[
267,
24... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abi... |
DB00024 | DB00912 | 818 | 473 | [
"DDInter1800",
"DDInter1581"
] | Thyrotropin alfa | Repaglinide | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
818,
24,
473
]
],
[
[
818,
24,
1645
],
[
1645,
24,
473
]
],
[
[
818,
24,
433
],
[
433,
63,
473
]
],
[
[
818,
24,
1645
],
[
1645,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflo... |
DB00445 | DB01259 | 322 | 392 | [
"DDInter655",
"DDInter1024"
] | Epirubicin | Lapatinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
322,
24,
392
]
],
[
[
322,
5,
11579
],
[
11579,
44,
392
]
],
[
[
322,
18,
2097
],
[
2097,
45,
392
]
],
[
[
322,
18,
10780
],
[
10780,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Epirubicin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treat... | Epirubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Epirubicin (Compound) downregulates ERBB2 (Gene) and ERBB2 (Gene) is bound by Lapatinib (Compound)
Epirubicin (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
... |
DB00960 | DB05812 | 887 | 1,374 | [
"DDInter1471",
"DDInter8"
] | Pindolol | Abiraterone | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
887,
24,
1374
]
],
[
[
887,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
887,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
887,
24,
760
],
[
760,... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Pindolol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Pindolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Pindolol (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicist... |
DB01169 | DB09472 | 57 | 1,383 | [
"DDInter120",
"DDInter1693"
] | Arsenic trioxide | Sodium sulfate | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Major | 2 | [
[
[
57,
25,
1383
]
],
[
[
57,
25,
609
],
[
609,
24,
1383
]
],
[
[
57,
64,
521
],
[
521,
24,
1383
]
],
[
[
57,
25,
1612
],
[
1612,
63... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clari... | Arsenic trioxide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Arsenic trioxide may lead to a major life threatening interaction when taken with Goserelin and Goserelin may... |
DB00620 | DB00991 | 175 | 97 | [
"DDInter1855",
"DDInter1358"
] | Triamcinolone | Oxaprozin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
175,
24,
97
]
],
[
[
175,
63,
362
],
[
362,
1,
97
]
],
[
[
175,
24,
1274
],
[
1274,
24,
97
]
],
[
[
175,
23,
307
],
[
307,
1,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction tha... |
DB01124 | DB04575 | 1,411 | 35 | [
"DDInter1828",
"DDInter1555"
] | Tolbutamide | Quinestrol | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
1411,
24,
35
]
],
[
[
1411,
63,
566
],
[
566,
1,
35
]
],
[
[
1411,
24,
984
],
[
984,
40,
35
]
],
[
[
1411,
63,
1336
],
[
1336,
4... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Quinestrol (Compou... |
DB00285 | DB00775 | 1,100 | 1,226 | [
"DDInter1927",
"DDInter1818"
] | Venlafaxine | Tirofiban | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Moderate | 1 | [
[
[
1100,
24,
1226
]
],
[
[
1100,
21,
28681
],
[
28681,
60,
1226
]
],
[
[
1100,
24,
714
],
[
714,
63,
1226
]
],
[
[
1100,
25,
1039
],
[
10... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tirofiban"
]
],
[
[
"Venlafaxine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side ... | Venlafaxine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Tirofiban (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken w... |
DB04845 | DB08870 | 309 | 850 | [
"DDInter1001",
"DDInter228"
] | Ixabepilone | Brentuximab vedotin | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
309,
24,
850
]
],
[
[
309,
24,
788
],
[
788,
24,
850
]
],
[
[
309,
63,
671
],
[
671,
24,
850
]
],
[
[
309,
24,
496
],
[
496,
63,... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Fluvas... |
DB00924 | DB06282 | 1,405 | 516 | [
"DDInter454",
"DDInter1053"
] | Cyclobenzaprine | Levocetirizine | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1405,
24,
516
]
],
[
[
1405,
63,
701
],
[
701,
24,
516
]
],
[
[
1405,
40,
1302
],
[
1302,
24,
516
]
],
[
[
1405,
24,
407
],
[
407,
... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
... | Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Cyclobenzaprine (Compound) resembles Protriptyline (Compound) and Protriptyline may cause a moderate in... |
DB00819 | DB00912 | 471 | 473 | [
"DDInter15",
"DDInter1581"
] | Acetazolamide | Repaglinide | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
471,
24,
473
]
],
[
[
471,
6,
8374
],
[
8374,
45,
473
]
],
[
[
471,
21,
28876
],
[
28876,
60,
473
]
],
[
[
471,
64,
1645
],
[
1645,
... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Acetazolamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Acetazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Acetazolamide (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Repaglinide (Compound)
Acetazolamide may lead to a major life threatening interaction when taken wi... |
DB00582 | DB12001 | 1,622 | 564 | [
"DDInter1946",
"DDInter7"
] | Voriconazole | Abemaciclib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1622,
25,
564
]
],
[
[
1622,
63,
1051
],
[
1051,
24,
564
]
],
[
[
1622,
25,
868
],
[
868,
24,
564
]
],
[
[
1622,
74,
600
],
[
600,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Voriconazole may lead to a major life threatening interaction when taken with Vemurafenib and V... |
DB06228 | DB11793 | 792 | 738 | [
"DDInter1609",
"DDInter1297"
] | Rivaroxaban | Niraparib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
792,
24,
738
]
],
[
[
792,
24,
466
],
[
466,
63,
738
]
],
[
[
792,
64,
1213
],
[
1213,
24,
738
]
],
[
[
792,
25,
1598
],
[
1598,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Rivaroxaban may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cau... |
DB00342 | DB00916 | 1,181 | 112 | [
"DDInter1770",
"DDInter1202"
] | Terfenadine | Metronidazole | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
1181,
23,
112
]
],
[
[
1181,
63,
847
],
[
847,
23,
112
]
],
[
[
1181,
24,
843
],
[
843,
62,
112
]
],
[
[
1181,
24,
87
],
[
87,
2... | [
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine an... |
DB00465 | DB01222 | 886 | 617 | [
"DDInter1010",
"DDInter246"
] | Ketorolac | Budesonide | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
886,
24,
617
]
],
[
[
886,
63,
251
],
[
251,
1,
617
]
],
[
[
886,
24,
175
],
[
175,
1,
617
]
],
[
[
886,
7,
2592
],
[
2592,
46,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[
... | Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Budesonide (... |
DB00791 | DB11943 | 132 | 255 | [
"DDInter1902",
"DDInter495"
] | Uracil mustard | Delafloxacin | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
132,
23,
255
]
],
[
[
132,
24,
869
],
[
869,
23,
255
]
],
[
[
132,
1,
970
],
[
970,
23,
255
]
],
[
[
132,
24,
869
],
[
869,
63,
... | [
[
[
"Uracil mustard",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
],
... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Uracil mustard (Compound) resembles Fluorouracil (Compound) and Fluorouracil may cause a minor interaction tha... |
DB00026 | DB01076 | 1,184 | 700 | [
"DDInter94",
"DDInter133"
] | Anakinra | Atorvastatin | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
1184,
24,
700
]
],
[
[
1184,
24,
303
],
[
303,
23,
700
]
],
[
[
1184,
24,
896
],
[
896,
24,
700
]
],
[
[
1184,
24,
1491
],
[
1491,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone acetate"
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Atorvastatin
Anakinra may cause a moderate interaction that could exacerbate diseases when ta... |
DB01097 | DB01124 | 1,377 | 1,411 | [
"DDInter1033",
"DDInter1828"
] | Leflunomide | Tolbutamide | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1377,
24,
1411
]
],
[
[
1377,
63,
959
],
[
959,
40,
1411
]
],
[
[
1377,
6,
6017
],
[
6017,
45,
1411
]
],
[
[
1377,
21,
29455
],
[
2945... | [
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Leflunomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Tolbutamide (Compound)
Leflunomide (Compound) causes Agranulocytosis (Side Effect) and ... |
DB08896 | DB11967 | 292 | 710 | [
"DDInter1576",
"DDInter210"
] | Regorafenib | Binimetinib | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Major | 2 | [
[
[
292,
25,
710
]
],
[
[
292,
63,
441
],
[
441,
24,
710
]
],
[
[
292,
24,
68
],
[
68,
63,
710
]
],
[
[
292,
24,
129
],
[
129,
24,
... | [
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Binimetinib"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
],
[
"Delavi... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Troleandomycin a... |
DB00570 | DB14783 | 147 | 287 | [
"DDInter1936",
"DDInter574"
] | Vinblastine | Diroximel fumarate | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
147,
24,
287
]
],
[
[
147,
63,
1101
],
[
1101,
24,
287
]
],
[
[
147,
24,
812
],
[
812,
24,
287
]
],
[
[
147,
25,
384
],
[
384,
2... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab ... |
DB08870 | DB14761 | 850 | 242 | [
"DDInter228",
"DDInter1578"
] | Brentuximab vedotin | Remdesivir | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
850,
24,
242
]
],
[
[
850,
63,
1130
],
[
1130,
24,
242
]
],
[
[
850,
64,
1377
],
[
1377,
24,
242
]
],
[
[
850,
24,
129
],
[
129,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitaz... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Brentuximab vedotin may lead to a major life threatening interaction when taken with Leflunomide an... |
DB00374 | DB01170 | 1,061 | 1,150 | [
"DDInter1852",
"DDInter846"
] | Treprostinil | Guanethidine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Moderate | 1 | [
[
[
1061,
24,
1150
]
],
[
[
1061,
24,
1445
],
[
1445,
24,
1150
]
],
[
[
1061,
24,
1344
],
[
1344,
63,
1150
]
],
[
[
1061,
1,
885
],
[
885,... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanethidine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Guanethidine
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Canag... |
DB00808 | DB01132 | 1,605 | 1,130 | [
"DDInter916",
"DDInter1472"
] | Indapamide | Pioglitazone | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
1605,
24,
1130
]
],
[
[
1605,
6,
8374
],
[
8374,
45,
1130
]
],
[
[
1605,
21,
28778
],
[
28778,
60,
1130
]
],
[
[
1605,
24,
688
],
[
68... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Indapamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Indapamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pioglitazone (Compound)
Indapamide (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound)
Indapamide may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00395 | DB12500 | 210 | 283 | [
"DDInter301",
"DDInter714"
] | Carisoprodol | Fedratinib | Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with b... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
210,
24,
283
]
],
[
[
210,
24,
401
],
[
401,
24,
283
]
],
[
[
210,
62,
168
],
[
168,
24,
283
]
],
[
[
210,
24,
913
],
[
913,
25,... | [
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Carisoprodol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Carisoprodol may cause a minor interaction that can limit clinical effects when taken with Bortezomib and ... |
DB00238 | DB09143 | 188 | 313 | [
"DDInter1285",
"DDInter1701"
] | Nevirapine | Sonidegib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
188,
25,
313
]
],
[
[
188,
24,
379
],
[
379,
23,
313
]
],
[
[
188,
24,
478
],
[
478,
24,
313
]
],
[
[
188,
25,
484
],
[
484,
63,... | [
[
[
"Nevirapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
"Rabeprazol... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotini... |
DB01254 | DB04911 | 1,213 | 968 | [
"DDInter484",
"DDInter1347"
] | Dasatinib | Oritavancin | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Oritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). Oritavancin was initially approved by the FDA in 2014 and formulated to combat susceptible gram-positive bacteria that cause skin and skin structure infections. It boasts... | Moderate | 1 | [
[
[
1213,
24,
968
]
],
[
[
1213,
24,
1079
],
[
1079,
1,
968
]
],
[
[
1213,
21,
28883
],
[
28883,
60,
968
]
],
[
[
1213,
64,
126
],
[
126,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oritavancin"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin (Compound) resembles Oritavancin (Compound)
Dasatinib (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Oritavancin (Compound)
Dasatinib may lead to a major life t... |
DB00748 | DB12161 | 662 | 730 | [
"DDInter297",
"DDInter512"
] | Carbinoxamine | Deutetrabenazine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
662,
24,
730
]
],
[
[
662,
35,
100
],
[
100,
24,
730
]
],
[
[
662,
24,
1264
],
[
1264,
24,
730
]
],
[
[
662,
63,
1219
],
[
1219,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases ... | Carbinoxamine (Compound) resembles Brompheniramine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Carbinoxamine may cause a m... |
DB06402 | DB11901 | 1,079 | 913 | [
"DDInter1756",
"DDInter107"
] | Telavancin | Apalutamide | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1079,
24,
913
]
],
[
[
1079,
62,
112
],
[
112,
23,
913
]
],
[
[
1079,
63,
600
],
[
600,
24,
913
]
],
[
[
1079,
24,
28
],
[
28,
2... | [
[
[
"Telavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Telavancin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Telavancin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fl... |
DB00622 | DB11901 | 1,081 | 913 | [
"DDInter1287",
"DDInter107"
] | Nicardipine | Apalutamide | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1081,
25,
913
]
],
[
[
1081,
63,
600
],
[
600,
24,
913
]
],
[
[
1081,
24,
1619
],
[
1619,
63,
913
]
],
[
[
1081,
24,
1450
],
[
1450,
... | [
[
[
"Nicardipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
"Flucon... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ru... |
DB00460 | DB01269 | 612 | 38 | [
"DDInter1929",
"DDInter1386"
] | Verteporfin | Panitumumab | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006. | Moderate | 1 | [
[
[
612,
24,
38
]
],
[
[
612,
24,
92
],
[
92,
24,
38
]
],
[
[
612,
25,
213
],
[
213,
25,
38
]
],
[
[
612,
24,
92
],
[
92,
25,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panitumumab"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxsalen"
],
... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Methoxsalen and Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Panitumumab
Verteporfin may lead to a major life threatening interaction when taken with Aminolevulinic acid and Aminole... |
DB00467 | DB13749 | 1,467 | 1,473 | [
"DDInter644",
"DDInter1116"
] | Enoxacin | Magnesium gluconate | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
1467,
24,
1473
]
],
[
[
1467,
40,
1299
],
[
1299,
24,
1473
]
],
[
[
1467,
1,
872
],
[
872,
24,
1473
]
],
[
[
1467,
24,
544
],
[
544,
... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Enoxacin",
"{u} (Compound) resembles {v} (Compound)",
"Trovafloxacin"
],
[
"Trovafloxacin",
"{u} may caus... | Enoxacin (Compound) resembles Trovafloxacin (Compound) and Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Enoxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00477 | DB01169 | 216 | 57 | [
"DDInter363",
"DDInter120"
] | Chlorpromazine | Arsenic trioxide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
216,
25,
57
]
],
[
[
216,
6,
8374
],
[
8374,
45,
57
]
],
[
[
216,
23,
112
],
[
112,
23,
57
]
],
[
[
216,
24,
603
],
[
603,
63,
... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Chlorpromazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic triox... |
DB01075 | DB01118 | 1,376 | 33 | [
"DDInter569",
"DDInter76"
] | Diphenhydramine | Amiodarone | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
1376,
24,
33
]
],
[
[
1376,
24,
540
],
[
540,
1,
33
]
],
[
[
1376,
6,
7950
],
[
7950,
45,
33
]
],
[
[
1376,
21,
28779
],
[
28779,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Diphenhydramine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Diphenhydramine (Compound) causes Dry mouth (Side Effe... |
DB00697 | DB01181 | 876 | 1,532 | [
"DDInter1821",
"DDInter906"
] | Tizanidine | Ifosfamide | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
876,
24,
1532
]
],
[
[
876,
18,
17480
],
[
17480,
57,
1532
]
],
[
[
876,
21,
28996
],
[
28996,
60,
1532
]
],
[
[
876,
64,
1648
],
[
16... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Tizanidine",
"{u} (Compound) downregulates {v} (Gene)",
"ENOPH1"
],
[
"ENOPH1",
"{u} (Gene) is downregulated by ... | Tizanidine (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Ifosfamide (Compound)
Tizanidine (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Ifosfamide (Compound)
Tizanidine may lead to a major life threatening interaction ... |
DB00678 | DB11827 | 240 | 433 | [
"DDInter1095",
"DDInter669"
] | Losartan | Ertugliflozin | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
240,
24,
433
]
],
[
[
240,
63,
251
],
[
251,
24,
433
]
],
[
[
240,
40,
217
],
[
217,
24,
433
]
],
[
[
240,
24,
870
],
[
870,
24,... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[
... | Losartan may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Losartan (Compound) resembles Olmesartan (Compound) and Olmesartan may cause a moderate interaction that ... |
DB00263 | DB09268 | 1,029 | 1,662 | [
"DDInter1727",
"DDInter1464"
] | Sulfisoxazole | Picosulfuric acid | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1029,
24,
1662
]
],
[
[
1029,
63,
912
],
[
912,
24,
1662
]
],
[
[
1029,
1,
1247
],
[
1247,
24,
1662
]
],
[
[
1029,
40,
698
],
[
698,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon bet... | Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole ma... |
DB00910 | DB12010 | 1,041 | 214 | [
"DDInter1394",
"DDInter785"
] | Paricalcitol | Fostamatinib | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1041,
24,
214
]
],
[
[
1041,
63,
690
],
[
690,
24,
214
]
],
[
[
1041,
24,
179
],
[
179,
63,
214
]
],
[
[
1041,
24,
1155
],
[
1155,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl... |
DB00366 | DB00801 | 1,594 | 1,563 | [
"DDInter600",
"DDInter850"
] | Doxylamine | Halazepam | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Moderate | 1 | [
[
[
1594,
24,
1563
]
],
[
[
1594,
24,
686
],
[
686,
1,
1563
]
],
[
[
1594,
63,
902
],
[
902,
40,
1563
]
],
[
[
1594,
24,
481
],
[
481,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halazepam"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Oxazepam and Oxazepam (Compound) resembles Halazepam (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Halazepam (Compound)
Doxylamine... |
DB00290 | DB15965 | 329 | 1,330 | [
"DDInter219",
"DDInter1270"
] | Bleomycin | Naxitamab | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
329,
24,
1330
]
],
[
[
329,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
329,
25,
770
],
[
770,
24,
1330
]
],
[
[
329,
63,
1184
],
[
1184,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Bleomycin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a... |
DB05294 | DB14840 | 1,069 | 861 | [
"DDInter1917",
"DDInter1601"
] | Vandetanib | Ripretinib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1069,
24,
861
]
],
[
[
1069,
25,
351
],
[
351,
24,
861
]
],
[
[
1069,
24,
214
],
[
214,
24,
861
]
],
[
[
1069,
64,
392
],
[
392,
... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib... | Vandetanib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may ca... |
DB00570 | DB12240 | 147 | 110 | [
"DDInter1936",
"DDInter1485"
] | Vinblastine | Polatuzumab vedotin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
147,
24,
110
]
],
[
[
147,
24,
129
],
[
129,
23,
110
]
],
[
[
147,
24,
467
],
[
467,
24,
110
]
],
[
[
147,
63,
268
],
[
268,
24,... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Simvasta... |
DB00460 | DB00553 | 612 | 92 | [
"DDInter1929",
"DDInter1177"
] | Verteporfin | Methoxsalen | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Moderate | 1 | [
[
[
612,
24,
92
]
],
[
[
612,
54,
19243
],
[
19243,
15,
92
]
],
[
[
612,
21,
28680
],
[
28680,
60,
92
]
],
[
[
612,
24,
1276
],
[
1276,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxsalen"
]
],
[
[
"Verteporfin",
"{u} (Compound) is included by {v} (Pharmacologic Class)",
"Photosensitizing Activity"
],
[
"Photosens... | Verteporfin (Compound) is included by Photosensitizing Activity (Pharmacologic Class) and Photosensitizing Activity (Pharmacologic Class) includes Methoxsalen (Compound)
Verteporfin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Methoxsalen (Compound)
Verteporfin may cause a moderate interacti... |
DB06626 | DB13179 | 263 | 68 | [
"DDInter147",
"DDInter1882"
] | Axitinib | Troleandomycin | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
263,
25,
68
]
],
[
[
263,
63,
1101
],
[
1101,
23,
68
]
],
[
[
263,
63,
267
],
[
267,
24,
68
]
],
[
[
263,
64,
1220
],
[
1220,
24... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexo... |
DB00500 | DB04865 | 24 | 4 | [
"DDInter1831",
"DDInter1335"
] | Tolmetin | Omacetaxine mepesuccinate | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
24,
25,
4
]
],
[
[
24,
6,
7720
],
[
7720,
46,
4
]
],
[
[
24,
18,
16896
],
[
16896,
57,
4
]
],
[
[
24,
63,
1645
],
[
1645,
24,
... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Tolmetin",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v} (Compound)",... | Tolmetin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolmetin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00775 | DB11703 | 1,226 | 405 | [
"DDInter1818",
"DDInter9"
] | Tirofiban | Acalabrutinib | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1226,
25,
405
]
],
[
[
1226,
63,
383
],
[
383,
24,
405
]
],
[
[
1226,
24,
643
],
[
643,
24,
405
]
],
[
[
1226,
24,
738
],
[
738,
... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00431 | DB01192 | 1,503 | 560 | [
"DDInter1072",
"DDInter1372"
] | Lindane | Oxymorphone | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
1503,
24,
560
]
],
[
[
1503,
24,
828
],
[
828,
1,
560
]
],
[
[
1503,
63,
421
],
[
421,
1,
560
]
],
[
[
1503,
21,
28719
],
[
28719,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
"O... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Oxymorphone (Compound)
... |
DB00615 | DB00912 | 690 | 473 | [
"DDInter1589",
"DDInter1581"
] | Rifabutin | Repaglinide | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
690,
24,
473
]
],
[
[
690,
6,
8374
],
[
8374,
45,
473
]
],
[
[
690,
21,
28763
],
[
28763,
60,
473
]
],
[
[
690,
24,
609
],
[
609,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Rifabutin (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Repaglinide (Compound)
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and... |
DB00939 | DB01234 | 1,338 | 1,220 | [
"DDInter1135",
"DDInter513"
] | Meclofenamic acid | Dexamethasone | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1338,
24,
1220
]
],
[
[
1338,
63,
870
],
[
870,
1,
1220
]
],
[
[
1338,
63,
175
],
[
175,
40,
1220
]
],
[
[
1338,
24,
617
],
[
617,
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocort... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound)... |
DB09128 | DB09472 | 1,241 | 1,383 | [
"DDInter231",
"DDInter1693"
] | Brexpiprazole | Sodium sulfate | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1241,
24,
1383
]
],
[
[
1241,
64,
609
],
[
609,
24,
1383
]
],
[
[
1241,
63,
1528
],
[
1528,
24,
1383
]
],
[
[
1241,
24,
407
],
[
407,
... | [
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Brexpiprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
... | Brexpiprazole may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Brexpiprazole may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and ... |
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