drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00470 | DB11859 | 530 | 418 | [
"DDInter601",
"DDInter230"
] | Dronabinol | Brexanolone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like various other types of depr... | Moderate | 1 | [
[
[
530,
24,
418
]
],
[
[
530,
24,
820
],
[
820,
24,
418
]
],
[
[
530,
63,
1648
],
[
1648,
24,
418
]
],
[
[
530,
1,
1614
],
[
1614,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexanolone"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Brexanolone
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Al... |
DB01128 | DB06636 | 918 | 1,623 | [
"DDInter204",
"DDInter980"
] | Bicalutamide | Isavuconazonium | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
918,
24,
1623
]
],
[
[
918,
63,
1557
],
[
1557,
24,
1623
]
],
[
[
918,
24,
309
],
[
309,
24,
1623
]
],
[
[
918,
25,
1593
],
[
1593,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
],... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone ... |
DB00188 | DB00601 | 168 | 453 | [
"DDInter222",
"DDInter1073"
] | Bortezomib | Linezolid | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
168,
24,
453
]
],
[
[
168,
7,
3603
],
[
3603,
46,
453
]
],
[
[
168,
7,
20113
],
[
20113,
57,
453
]
],
[
[
168,
21,
29121
],
[
29121,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Bortezomib",
"{u} (Compound) upregulates {v} (Gene)",
"ZFP36"
],
[
"ZFP36",
"{u} (Gene) is upregulated by {v} (Co... | Bortezomib (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Linezolid (Compound)
Bortezomib (Compound) upregulates IER3 (Gene) and IER3 (Gene) is downregulated by Linezolid (Compound)
Bortezomib (Compound) causes Thrombophlebitis (Side Effect) and Thrombophlebitis (Side Effect) is caused by Linezo... |
DB00690 | DB00719 | 1,216 | 1,219 | [
"DDInter762",
"DDInter149"
] | Flurazepam | Azatadine | A benzodiazepine derivative used mainly as a hypnotic. | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1216,
24,
1219
]
],
[
[
1216,
63,
13
],
[
13,
24,
1219
]
],
[
[
1216,
24,
830
],
[
830,
1,
1219
]
],
[
[
1216,
6,
8374
],
[
8374,
... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[... | Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine a... |
DB00486 | DB00564 | 1,614 | 1,236 | [
"DDInter1253",
"DDInter293"
] | Nabilone | Carbamazepine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
1614,
24,
1236
]
],
[
[
1614,
24,
1405
],
[
1405,
40,
1236
]
],
[
[
1614,
63,
508
],
[
508,
1,
1236
]
],
[
[
1614,
24,
104
],
[
104,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
],
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Carbamazepine (... |
DB00377 | DB01246 | 1,494 | 820 | [
"DDInter1382",
"DDInter45"
] | Palonosetron | Alimemazine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1494,
24,
820
]
],
[
[
1494,
24,
401
],
[
401,
24,
820
]
],
[
[
1494,
24,
675
],
[
675,
25,
820
]
],
[
[
1494,
24,
508
],
[
508,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Dextropropox... |
DB00358 | DB06616 | 1,010 | 594 | [
"DDInter1140",
"DDInter224"
] | Mefloquine | Bosutinib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1010,
24,
594
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1010,
7,
1986
],
[
1986,
46,
594
]
],
[
[
1010,
21,
29231
],
[
29231,... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Mefloquine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Bosutinib (Compound)
Mefloquine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Bosutinib (Com... |
DB00211 | DB05812 | 1,290 | 1,374 | [
"DDInter1213",
"DDInter8"
] | Midodrine | Abiraterone | An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1290,
24,
1374
]
],
[
[
1290,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
1290,
21,
28880
],
[
28880,
60,
1374
]
],
[
[
1290,
24,
760
],
[
... | [
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Midodrine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Midodrine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Midodrine (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Abiraterone (Compound)
Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cob... |
DB00468 | DB00831 | 1,424 | 1,178 | [
"DDInter1557",
"DDInter1866"
] | Quinine | Trifluoperazine | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1424,
24,
1178
]
],
[
[
1424,
64,
695
],
[
695,
40,
1178
]
],
[
[
1424,
24,
851
],
[
851,
40,
1178
]
],
[
[
1424,
24,
9
],
[
9,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Clozapine",
... | Quinine may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Trifluoperazine (Compound)
Quinine may c... |
DB00286 | DB11921 | 380 | 1,019 | [
"DDInter440",
"DDInter492"
] | Conjugated estrogens (topical) | Deflazacort | Estrone sodium sulfate is a steroid sulfate and an organic sodium salt. It is functionally related to an estrone. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
380,
24,
1019
]
],
[
[
380,
24,
959
],
[
959,
24,
1019
]
],
[
[
380,
40,
890
],
[
890,
24,
1019
]
],
[
[
380,
24,
1385
],
[
1385,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipiz... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with De... |
DB09156 | DB15066 | 777 | 445 | [
"DDInter964",
"DDInter821"
] | Iopromide | Givosiran | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Major | 2 | [
[
[
777,
25,
445
]
],
[
[
777,
64,
589
],
[
589,
24,
445
]
],
[
[
777,
64,
629
],
[
629,
25,
445
]
],
[
[
777,
64,
589
],
[
589,
24,... | [
[
[
"Iopromide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Givosiran"
]
],
[
[
"Iopromide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
],
[
"Cisplatin",
"{u} may ca... | Iopromide may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Iopromide may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may lead to a major life threate... |
DB00307 | DB11718 | 1,101 | 927 | [
"DDInter202",
"DDInter640"
] | Bexarotene | Encorafenib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1101,
24,
927
]
],
[
[
1101,
24,
372
],
[
372,
24,
927
]
],
[
[
1101,
23,
536
],
[
536,
24,
927
]
],
[
[
1101,
62,
1324
],
[
1324,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Secobarbital and Sec... |
DB00026 | DB00277 | 1,184 | 1,031 | [
"DDInter94",
"DDInter1791"
] | Anakinra | Theophylline | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Moderate | 1 | [
[
[
1184,
24,
1031
]
],
[
[
1184,
24,
523
],
[
523,
62,
1031
]
],
[
[
1184,
24,
759
],
[
759,
63,
1031
]
],
[
[
1184,
25,
980
],
[
980,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone m... |
DB00563 | DB05679 | 663 | 1,683 | [
"DDInter1174",
"DDInter1907"
] | Methotrexate | Ustekinumab | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
663,
24,
1683
]
],
[
[
663,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
663,
24,
1042
],
[
1042,
24,
1683
]
],
[
[
663,
24,
1362
],
[
1362,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and T... |
DB01015 | DB01254 | 1,247 | 1,213 | [
"DDInter1724",
"DDInter484"
] | Sulfamethoxazole | Dasatinib | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Minor | 0 | [
[
[
1247,
23,
1213
]
],
[
[
1247,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1247,
18,
10375
],
[
10375,
57,
1213
]
],
[
[
1247,
21,
28882
],
[
... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dasatinib"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Sulfamethoxazole (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dasatinib (Compound)
Sulfamethoxazole (Compound) causes Body temperature increased (Side Effect) and Body temperature increased... |
DB08860 | DB11718 | 788 | 927 | [
"DDInter1479",
"DDInter640"
] | Pitavastatin | Encorafenib | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
788,
24,
927
]
],
[
[
788,
63,
112
],
[
112,
23,
927
]
],
[
[
788,
63,
372
],
[
372,
24,
927
]
],
[
[
788,
24,
484
],
[
484,
63,... | [
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine ... |
DB00196 | DB01169 | 600 | 57 | [
"DDInter743",
"DDInter120"
] | Fluconazole | Arsenic trioxide | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
600,
25,
57
]
],
[
[
600,
6,
8374
],
[
8374,
45,
57
]
],
[
[
600,
23,
1247
],
[
1247,
23,
57
]
],
[
[
600,
24,
603
],
[
603,
63,... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic triox... |
DB00731 | DB01208 | 1,144 | 945 | [
"DDInter1269",
"DDInter1705"
] | Nateglinide | Sparfloxacin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
1144,
25,
945
]
],
[
[
1144,
25,
739
],
[
739,
1,
945
]
],
[
[
1144,
64,
1176
],
[
1176,
1,
945
]
],
[
[
1144,
21,
28787
],
[
28787,
... | [
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
... | Nateglinide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Nateglinide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Compound)
Nateglinide (Com... |
DB00655 | DB00860 | 559 | 891 | [
"DDInter682",
"DDInter1513"
] | Estrone | Prednisolone | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
559,
24,
891
]
],
[
[
559,
63,
175
],
[
175,
40,
891
]
],
[
[
559,
24,
1547
],
[
1547,
1,
891
]
],
[
[
559,
1,
1561
],
[
1561,
2... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Exemestane and Exemestane (Compound) resembles Prednisolone (Compou... |
DB00092 | DB12267 | 58 | 1,476 | [
"DDInter40",
"DDInter233"
] | Alefacept | Brigatinib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
58,
24,
1476
]
],
[
[
58,
24,
168
],
[
168,
23,
1476
]
],
[
[
58,
24,
629
],
[
629,
24,
1476
]
],
[
[
58,
63,
1184
],
[
1184,
24... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus m... |
DB00622 | DB09280 | 1,081 | 1,604 | [
"DDInter1287",
"DDInter1101"
] | Nicardipine | Lumacaftor | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1081,
25,
1604
]
],
[
[
1081,
63,
1061
],
[
1061,
24,
1604
]
],
[
[
1081,
24,
593
],
[
593,
24,
1604
]
],
[
[
1081,
24,
629
],
[
629,
... | [
[
[
"Nicardipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Trepro... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Bupropion and B... |
DB00056 | DB10429 | 816 | 200 | [
"DDInter814",
"DDInter282"
] | Gemtuzumab ozogamicin | Candida albicans | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
816,
24,
200
]
],
[
[
816,
24,
1683
],
[
1683,
24,
200
]
],
[
[
816,
25,
976
],
[
976,
24,
200
]
],
[
[
816,
24,
738
],
[
738,
6... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Gemtuzumab ozogamicin may lead to a major life threatening interaction when taken with Tofaci... |
DB00939 | DB01254 | 1,338 | 1,213 | [
"DDInter1135",
"DDInter484"
] | Meclofenamic acid | Dasatinib | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1338,
25,
1213
]
],
[
[
1338,
18,
6212
],
[
6212,
57,
1213
]
],
[
[
1338,
21,
28956
],
[
28956,
60,
1213
]
],
[
[
1338,
24,
738
],
[
7... | [
[
[
"Meclofenamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Meclofenamic acid",
"{u} (Compound) downregulates {v} (Gene)",
"CSRP1"
],
[
"CSRP1",
"{u} (Gene) is downregulated by {v} ... | Meclofenamic acid (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Dasatinib (Compound)
Meclofenamic acid (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dasatinib (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate disea... |
DB00759 | DB09275 | 1,620 | 813 | [
"DDInter1783",
"DDInter213"
] | Tetracycline | Bismuth subcitrate potassium | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | A bismuth compound used for peptic ulcer and gastro-oesophageal reflux disease (GORD). | Moderate | 1 | [
[
[
1620,
24,
813
]
],
[
[
1620,
1,
1572
],
[
1572,
24,
813
]
],
[
[
1620,
1,
1572
],
[
1572,
1,
1669
],
[
1669,
24,
813
]
],
[
[
1620,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bismuth subcitrate potassium"
]
],
[
[
"Tetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
... | Tetracycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Bismuth subcitrate potassium
Tetracycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline (Compound) resembles Minocycline (Compound) and Minoc... |
DB06204 | DB06691 | 768 | 849 | [
"DDInter1746",
"DDInter1155"
] | Tapentadol | Mepyramine | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
768,
24,
849
]
],
[
[
768,
63,
1594
],
[
1594,
24,
849
]
],
[
[
768,
6,
12523
],
[
12523,
45,
849
]
],
[
[
768,
24,
412
],
[
412,
... | [
[
[
"Tapentadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Tapentadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Tapentadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Tapentadol may cau... |
DB11828 | DB11943 | 1,406 | 255 | [
"DDInter1281",
"DDInter495"
] | Neratinib | Delafloxacin | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1406,
24,
255
]
],
[
[
1406,
63,
896
],
[
896,
23,
255
]
],
[
[
1406,
63,
1283
],
[
1283,
24,
255
]
],
[
[
1406,
25,
913
],
[
913,
... | [
[
[
"Neratinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Neratinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Neratinib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Neratinib may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magne... |
DB08916 | DB11791 | 26 | 785 | [
"DDInter32",
"DDInter287"
] | Afatinib | Capmatinib | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
26,
24,
785
]
],
[
[
26,
63,
868
],
[
868,
24,
785
]
],
[
[
26,
24,
1320
],
[
1320,
63,
785
]
],
[
[
26,
24,
351
],
[
351,
24,
... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix m... |
DB00934 | DB00986 | 413 | 1,192 | [
"DDInter1124",
"DDInter834"
] | Maprotiline | Glycopyrronium | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
413,
24,
1192
]
],
[
[
413,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
413,
63,
262
],
[
262,
24,
1192
]
],
[
[
413,
6,
2720
],
[
2720,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and... |
DB01155 | DB13142 | 872 | 841 | [
"DDInter813",
"DDInter274"
] | Gemifloxacin | Calcium glubionate anhydrous | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
872,
24,
841
]
],
[
[
872,
40,
246
],
[
246,
24,
841
]
],
[
[
872,
1,
945
],
[
945,
24,
841
]
],
[
[
872,
40,
246
],
[
246,
1,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Gatifloxacin"
],
[
"Gatifloxacin",
... | Gemifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Gemifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseas... |
DB00059 | DB01438 | 1,560 | 585 | [
"DDInter1404",
"DDInter1438"
] | Pegaspargase | Phenazopyridine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is still us... | Moderate | 1 | [
[
[
1560,
24,
585
]
],
[
[
1560,
24,
384
],
[
384,
63,
585
]
],
[
[
1560,
24,
372
],
[
372,
24,
585
]
],
[
[
1560,
25,
1510
],
[
1510,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenazopyridine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Phenazopyridine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine ... |
DB01023 | DB11718 | 409 | 927 | [
"DDInter716",
"DDInter640"
] | Felodipine | Encorafenib | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
409,
24,
927
]
],
[
[
409,
63,
1324
],
[
1324,
24,
927
]
],
[
[
409,
40,
84
],
[
84,
24,
927
]
],
[
[
409,
1,
1081
],
[
1081,
24... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Felodipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction tha... |
DB00530 | DB06723 | 1,195 | 115 | [
"DDInter667",
"DDInter58"
] | Erlotinib | Aluminum hydroxide | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
1195,
24,
115
]
],
[
[
1195,
21,
28643
],
[
28643,
60,
115
]
],
[
[
1195,
24,
1072
],
[
1072,
23,
115
]
],
[
[
1195,
63,
752
],
[
752,... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Erlotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effect) i... | Erlotinib (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Alumi... |
DB00448 | DB00738 | 1,215 | 485 | [
"DDInter1022",
"DDInter1420"
] | Lansoprazole | Pentamidine | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
1215,
24,
485
]
],
[
[
1215,
6,
12523
],
[
12523,
45,
485
]
],
[
[
1215,
21,
29097
],
[
29097,
60,
485
]
],
[
[
1215,
24,
913
],
[
913... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Lansoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compou... | Lansoprazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pentamidine (Compound)
Lansoprazole (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Pentamidine (Compound)
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide a... |
DB01001 | DB01128 | 688 | 918 | [
"DDInter1632",
"DDInter204"
] | Salbutamol | Bicalutamide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
688,
24,
918
]
],
[
[
688,
24,
129
],
[
129,
40,
918
]
],
[
[
688,
6,
8374
],
[
8374,
45,
918
]
],
[
[
688,
21,
28642
],
[
28642,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Salbutamol (Compound) causes Shock (Side Effect) and Shock... |
DB00515 | DB14761 | 589 | 242 | [
"DDInter387",
"DDInter1578"
] | Cisplatin | Remdesivir | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
589,
24,
242
]
],
[
[
589,
24,
467
],
[
467,
24,
242
]
],
[
[
589,
25,
1377
],
[
1377,
24,
242
]
],
[
[
589,
63,
482
],
[
482,
2... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Cisplatin may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may caus... |
DB00862 | DB05812 | 1,005 | 1,374 | [
"DDInter1918",
"DDInter8"
] | Vardenafil | Abiraterone | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1005,
24,
1374
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
1005,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
1005,
24,
112
],
[
11... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Vardenafil (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when ... |
DB00436 | DB01261 | 323 | 170 | [
"DDInter179",
"DDInter1679"
] | Bendroflumethiazide | Sitagliptin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
323,
24,
170
]
],
[
[
323,
21,
28921
],
[
28921,
60,
170
]
],
[
[
323,
24,
52
],
[
52,
62,
170
]
],
[
[
323,
24,
708
],
[
708,
6... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (S... | Bendroflumethiazide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compound)
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when... |
DB00327 | DB09268 | 421 | 1,662 | [
"DDInter890",
"DDInter1464"
] | Hydromorphone | Picosulfuric acid | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
421,
24,
1662
]
],
[
[
421,
24,
1494
],
[
1494,
24,
1662
]
],
[
[
421,
40,
993
],
[
993,
24,
1662
]
],
[
[
421,
64,
475
],
[
475,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palonosetron"
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Hydromorphone (Compound) resembles Diamorphine (Compound) and Diamorphine may cause a moderate int... |
DB00451 | DB09146 | 542 | 489 | [
"DDInter1064",
"DDInter978"
] | Levothyroxine | Iron sucrose | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
542,
24,
489
]
],
[
[
542,
24,
260
],
[
260,
63,
489
]
],
[
[
542,
40,
1152
],
[
1152,
24,
489
]
],
[
[
542,
24,
954
],
[
954,
2... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anh... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Ferrous sulfate anhydrous and Ferrous sulfate anhydrous may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Levothyroxine (Compound) resembles Liothyronine (Compound) and Liothyronine m... |
DB01105 | DB09080 | 222 | 144 | [
"DDInter1665",
"DDInter1331"
] | Sibutramine | Olodaterol | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
222,
24,
144
]
],
[
[
222,
63,
504
],
[
504,
24,
144
]
],
[
[
222,
24,
1301
],
[
1301,
24,
144
]
],
[
[
222,
64,
534
],
[
534,
2... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with L... |
DB00655 | DB09564 | 559 | 1,296 | [
"DDInter682",
"DDInter930"
] | Estrone | Insulin degludec | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
559,
24,
1296
]
],
[
[
559,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
559,
63,
1645
],
[
1645,
24,
1296
]
],
[
[
559,
1,
380
],
[
380,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
[
... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metfo... |
DB00691 | DB01390 | 1,058 | 1,117 | [
"DDInter1237",
"DDInter1683"
] | Moexipril | Sodium bicarbonate | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
1058,
23,
1117
]
],
[
[
1058,
24,
1220
],
[
1220,
23,
1117
]
],
[
[
1058,
40,
1638
],
[
1638,
23,
1117
]
],
[
[
1058,
63,
1573
],
[
15... | [
[
[
"Moexipril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Moexipril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a minor interaction... |
DB00005 | DB00023 | 1,057 | 305 | [
"DDInter687",
"DDInter127"
] | Etanercept | Asparaginase Escherichia coli | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Major | 2 | [
[
[
1057,
25,
305
]
],
[
[
1057,
24,
14
],
[
14,
63,
305
]
],
[
[
1057,
25,
384
],
[
384,
63,
305
]
],
[
[
1057,
24,
1451
],
[
1451,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Asparaginase Escherichia coli"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
],
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli
Etanercept may lead to a major life threatening interaction when taken with Idelalisib an... |
DB00006 | DB00055 | 942 | 834 | [
"DDInter217",
"DDInter605"
] | Bivalirudin | Drotrecogin alfa | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Major | 2 | [
[
[
942,
25,
834
]
],
[
[
942,
23,
539
],
[
539,
62,
834
]
],
[
[
942,
24,
318
],
[
318,
63,
834
]
],
[
[
942,
24,
1226
],
[
1226,
6... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Drotrecogin alfa"
]
],
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsic... | Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Drotrecogin alfa
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Esci... |
DB04868 | DB06212 | 478 | 165 | [
"DDInter1293",
"DDInter1833"
] | Nilotinib | Tolvaptan | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
478,
24,
165
]
],
[
[
478,
64,
1080
],
[
1080,
1,
165
]
],
[
[
478,
63,
522
],
[
522,
1,
165
]
],
[
[
478,
6,
8374
],
[
8374,
45... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",
... | Nilotinib may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Tolvaptan (Compound)
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast (Compound) resembles Tolvaptan (Compound)
Nilotinib (Compou... |
DB00970 | DB08826 | 0 | 1,292 | [
"DDInter466",
"DDInter489"
] | Dactinomycin | Deferiprone | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
0,
25,
1292
]
],
[
[
0,
18,
2215
],
[
2215,
57,
1292
]
],
[
[
0,
7,
7242
],
[
7242,
57,
1292
]
],
[
[
0,
21,
28809
],
[
28809,
6... | [
[
[
"Dactinomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Dactinomycin",
"{u} (Compound) downregulates {v} (Gene)",
"HSPA8"
],
[
"HSPA8",
"{u} (Gene) is downregulated by {v} (Compoun... | Dactinomycin (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Dactinomycin (Compound) upregulates PHKA1 (Gene) and PHKA1 (Gene) is downregulated by Deferiprone (Compound)
Dactinomycin (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Defe... |
DB00196 | DB01253 | 600 | 628 | [
"DDInter743",
"DDInter664"
] | Fluconazole | Ergometrine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Moderate | 1 | [
[
[
600,
24,
628
]
],
[
[
600,
24,
1131
],
[
1131,
40,
628
]
],
[
[
600,
6,
8374
],
[
8374,
45,
628
]
],
[
[
600,
21,
28748
],
[
28748,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergometrine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methysergide"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Ergometrine (Compound)
Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ergometrine (Compound)
Fluconazole (Compound) causes Vertigo (Side Effect) and Ve... |
DB00238 | DB08901 | 188 | 1,468 | [
"DDInter1285",
"DDInter1492"
] | Nevirapine | Ponatinib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
188,
24,
1468
]
],
[
[
188,
24,
478
],
[
478,
24,
1468
]
],
[
[
188,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
188,
21,
28883
],
[
28883,... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Nevirapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Nevirapine (Compound) ... |
DB00275 | DB01285 | 217 | 708 | [
"DDInter1330",
"DDInter445"
] | Olmesartan | Corticotropin | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
217,
24,
708
]
],
[
[
217,
24,
123
],
[
123,
24,
708
]
],
[
[
217,
24,
1662
],
[
1662,
63,
708
]
],
[
[
217,
1,
240
],
[
240,
24... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
[
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid an... |
DB00903 | DB01129 | 1,680 | 379 | [
"DDInter686",
"DDInter1559"
] | Etacrynic acid | Rabeprazole | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
1680,
24,
379
]
],
[
[
1680,
63,
1215
],
[
1215,
40,
379
]
],
[
[
1680,
63,
660
],
[
660,
1,
379
]
],
[
[
1680,
21,
28762
],
[
28762,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabep... |
DB00791 | DB11627 | 132 | 1,367 | [
"DDInter1902",
"DDInter860"
] | Uracil mustard | Hepatitis B Vaccine (Recombinant) | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
132,
24,
1367
]
],
[
[
132,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
132,
24,
259
],
[
259,
24,
1367
]
],
[
[
132,
25,
375
],
[
375,
... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"... | Uracil mustard may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Rilon... |
DB00834 | DB06788 | 932 | 1,616 | [
"DDInter1215",
"DDInter864"
] | Mifepristone | Histrelin | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
932,
25,
1616
]
],
[
[
932,
23,
112
],
[
112,
23,
1616
]
],
[
[
932,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
932,
24,
603
],
[
603,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Mifepristone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Mifepristone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Mifepristone may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may c... |
DB00358 | DB01044 | 1,010 | 246 | [
"DDInter1140",
"DDInter809"
] | Mefloquine | Gatifloxacin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
1010,
25,
246
]
],
[
[
1010,
24,
739
],
[
739,
1,
246
]
],
[
[
1010,
64,
1176
],
[
1176,
1,
246
]
],
[
[
1010,
25,
945
],
[
945,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
"Lomefl... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Mef... |
DB01211 | DB06292 | 609 | 549 | [
"DDInter393",
"DDInter474"
] | Clarithromycin | Dapagliflozin | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
609,
24,
549
]
],
[
[
609,
24,
1344
],
[
1344,
40,
549
]
],
[
[
609,
6,
8374
],
[
8374,
45,
549
]
],
[
[
609,
21,
29222
],
[
29222,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Clarithromycin (Compound) causes Hypoglycaemia... |
DB00448 | DB00808 | 1,215 | 1,605 | [
"DDInter1022",
"DDInter916"
] | Lansoprazole | Indapamide | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
1215,
24,
1605
]
],
[
[
1215,
24,
811
],
[
811,
1,
1605
]
],
[
[
1215,
24,
1335
],
[
1335,
40,
1605
]
],
[
[
1215,
6,
8374
],
[
8374,
... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Indapamide (... |
DB06699 | DB12332 | 774 | 1,619 | [
"DDInter493",
"DDInter1626"
] | Degarelix | Rucaparib | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
774,
24,
1619
]
],
[
[
774,
62,
112
],
[
112,
23,
1619
]
],
[
[
774,
63,
87
],
[
87,
24,
1619
]
],
[
[
774,
24,
1662
],
[
1662,
... | [
[
[
"Degarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Degarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Degarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapin... |
DB00019 | DB00563 | 1,257 | 663 | [
"DDInter1405",
"DDInter1174"
] | Pegfilgrastim | Methotrexate | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1257,
24,
663
]
],
[
[
1257,
24,
328
],
[
328,
62,
663
]
],
[
[
1257,
24,
738
],
[
738,
63,
663
]
],
[
[
1257,
24,
1648
],
[
1648,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Nirapar... |
DB00983 | DB01064 | 480 | 1,148 | [
"DDInter776",
"DDInter987"
] | Formoterol | Isoprenaline | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
480,
24,
1148
]
],
[
[
480,
63,
1636
],
[
1636,
24,
1148
]
],
[
[
480,
40,
1188
],
[
1188,
1,
1148
]
],
[
[
480,
64,
1523
],
[
1523,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Formoterol (Compound) resembles Arbutamine (Compound) and Arbutamine (Compound) resembles Isoprenaline (... |
DB00404 | DB11718 | 523 | 927 | [
"DDInter54",
"DDInter640"
] | Alprazolam | Encorafenib | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
523,
24,
927
]
],
[
[
523,
63,
1324
],
[
1324,
24,
927
]
],
[
[
523,
24,
770
],
[
770,
24,
927
]
],
[
[
523,
24,
484
],
[
484,
6... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and ... |
DB00992 | DB00999 | 842 | 504 | [
"DDInter1182",
"DDInter883"
] | Methyl aminolevulinate (topical) | Hydrochlorothiazide | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
842,
24,
504
]
],
[
[
842,
24,
178
],
[
178,
1,
504
]
],
[
[
842,
63,
323
],
[
323,
40,
504
]
],
[
[
842,
24,
674
],
[
674,
40,
... | [
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide
Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Methyl amino... |
DB00175 | DB08901 | 681 | 1,468 | [
"DDInter1509",
"DDInter1492"
] | Pravastatin | Ponatinib | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
681,
24,
1468
]
],
[
[
681,
6,
10083
],
[
10083,
45,
1468
]
],
[
[
681,
21,
29024
],
[
29024,
60,
1468
]
],
[
[
681,
24,
589
],
[
589,... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Pravastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB11"
],
[
"ABCB11",
"{u} (Gene) is bound by {v} (Compound)"... | Pravastatin (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Ponatinib (Compound)
Pravastatin (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Ponatinib (Compound)
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin an... |
DB00067 | DB01069 | 317 | 401 | [
"DDInter1921",
"DDInter1533"
] | Vasopressin | Promethazine | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
317,
24,
401
]
],
[
[
317,
24,
1264
],
[
1264,
63,
401
]
],
[
[
317,
23,
112
],
[
112,
23,
401
]
],
[
[
317,
24,
1559
],
[
1559,
... | [
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metroni... |
DB00694 | DB01035 | 51 | 1,401 | [
"DDInter485",
"DDInter1524"
] | Daunorubicin | Procainamide | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A derivative of procaine with less CNS action. | Major | 2 | [
[
[
51,
25,
1401
]
],
[
[
51,
6,
8803
],
[
8803,
45,
1401
]
],
[
[
51,
21,
28658
],
[
28658,
60,
1401
]
],
[
[
51,
23,
112
],
[
112,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procainamide"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A2"
],
[
"SLC22A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Daunorubicin (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Procainamide (Compound)
Daunorubicin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Procainamide (Compound)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00894 | DB09228 | 1,581 | 687 | [
"DDInter1774",
"DDInter437"
] | Testolactone | Conestat alfa | An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer. | C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibi... | Moderate | 1 | [
[
[
1581,
24,
687
]
],
[
[
1581,
1,
1561
],
[
1561,
24,
687
]
],
[
[
1581,
40,
559
],
[
559,
24,
687
]
],
[
[
1581,
25,
350
],
[
350,
... | [
[
[
"Testolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conestat alfa"
]
],
[
[
"Testolactone",
"{u} (Compound) resembles {v} (Compound)",
"Testosterone"
],
[
"Testosterone",
"{u} may caus... | Testolactone (Compound) resembles Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Testolactone (Compound) resembles Estrone (Compound) and Estrone may cause a moderate interaction that could exacerbate diseases when taken with Conest... |
DB01105 | DB09068 | 222 | 1,427 | [
"DDInter1665",
"DDInter1948"
] | Sibutramine | Vortioxetine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
222,
25,
1427
]
],
[
[
222,
63,
25
],
[
25,
24,
1427
]
],
[
[
222,
24,
256
],
[
256,
24,
1427
]
],
[
[
222,
24,
1017
],
[
1017,
... | [
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anistreplase"
],
[
"Anis... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and... |
DB00674 | DB01619 | 1,516 | 830 | [
"DDInter802",
"DDInter1441"
] | Galantamine | Phenindamine | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1516,
24,
830
]
],
[
[
1516,
24,
537
],
[
537,
40,
830
]
],
[
[
1516,
63,
13
],
[
13,
24,
830
]
],
[
[
1516,
24,
104
],
[
104,
1... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction ... |
DB00624 | DB01097 | 1,561 | 1,377 | [
"DDInter1776",
"DDInter1033"
] | Testosterone (topical) | Leflunomide | Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, an androstanoid, a C19-steroid and a 3-oxo-Delta(4) steroid. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1561,
25,
1377
]
],
[
[
1561,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
1561,
21,
29231
],
[
29231,
60,
1377
]
],
[
[
1561,
25,
126
],
[
12... | [
[
[
"Testosterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Testosterone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Le... | Testosterone may lead to a major life threatening interaction when taken with Leflunomide
Testosterone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Testosterone (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Leflunomide (Compound)
... |
DB00361 | DB01206 | 134 | 37 | [
"DDInter1939",
"DDInter1086"
] | Vinorelbine | Lomustine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
134,
24,
37
]
],
[
[
134,
5,
11555
],
[
11555,
44,
37
]
],
[
[
134,
6,
8374
],
[
8374,
45,
37
]
],
[
[
134,
21,
28722
],
[
28722,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Vinorelbine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disea... | Vinorelbine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomustine (Compound)
Vinorelbine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine ... |
DB00543 | DB01087 | 87 | 1,520 | [
"DDInter82",
"DDInter1520"
] | Amoxapine | Primaquine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
87,
24,
1520
]
],
[
[
87,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
87,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
87,
21,
28722
],
[
28722,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydr... | Amoxapine may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Amoxapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Amoxapine (Compound) causes Nausea... |
DB09030 | DB15093 | 840 | 1,654 | [
"DDInter1945",
"DDInter1698"
] | Vorapaxar | Somapacitan | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
840,
24,
1654
]
],
[
[
840,
64,
1512
],
[
1512,
24,
1654
]
],
[
[
840,
24,
159
],
[
159,
24,
1654
]
],
[
[
840,
25,
283
],
[
283,
... | [
[
[
"Vorapaxar",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Vorapaxar",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
],
[
"Diclofenac"... | Vorapaxar may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may c... |
DB00604 | DB04946 | 1,425 | 924 | [
"DDInter385",
"DDInter907"
] | Cisapride | Iloperidone | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
1425,
25,
924
]
],
[
[
1425,
40,
883
],
[
883,
1,
924
]
],
[
[
1425,
25,
1664
],
[
1664,
1,
924
]
],
[
[
1425,
25,
519
],
[
519,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Cisapride",
"{u} (Compound) resembles {v} (Compound)",
"Gefitinib"
],
[
"Gefitinib",
"{u} (Compound) resembles {v} (Compound)",... | Cisapride (Compound) resembles Gefitinib (Compound) and Gefitinib (Compound) resembles Iloperidone (Compound)
Cisapride may lead to a major life threatening interaction when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Cisapride may lead to a major life threatening interaction when... |
DB00563 | DB01438 | 663 | 585 | [
"DDInter1174",
"DDInter1438"
] | Methotrexate | Phenazopyridine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is still us... | Moderate | 1 | [
[
[
663,
24,
585
]
],
[
[
663,
21,
28658
],
[
28658,
60,
585
]
],
[
[
663,
24,
384
],
[
384,
63,
585
]
],
[
[
663,
24,
372
],
[
372,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenazopyridine"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) ... | Methotrexate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Phenazopyridine (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00451 | DB00564 | 542 | 1,236 | [
"DDInter1064",
"DDInter293"
] | Levothyroxine | Carbamazepine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
542,
24,
1236
]
],
[
[
542,
63,
362
],
[
362,
1,
1236
]
],
[
[
542,
63,
1302
],
[
1302,
40,
1236
]
],
[
[
542,
24,
1164
],
[
1164,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Carbamaze... |
DB00146 | DB00653 | 160 | 544 | [
"DDInter265",
"DDInter1120"
] | Calcifediol | Magnesium sulfate | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Moderate | 1 | [
[
[
160,
24,
544
]
],
[
[
160,
24,
1473
],
[
1473,
63,
544
]
],
[
[
160,
36,
386
],
[
386,
24,
544
]
],
[
[
160,
25,
1041
],
[
1041,
... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconat... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate and Magnesium gluconate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcifediol (Compound) resembles Cholecalciferol (Compound) and Calcifediol may lead t... |
DB00342 | DB01175 | 1,181 | 318 | [
"DDInter1770",
"DDInter672"
] | Terfenadine | Escitalopram | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Major | 2 | [
[
[
1181,
25,
318
]
],
[
[
1181,
64,
1230
],
[
1230,
1,
318
]
],
[
[
1181,
25,
86
],
[
86,
23,
318
]
],
[
[
1181,
24,
1478
],
[
1478,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
],
[
"Citalopram",
"{... | Terfenadine may lead to a major life threatening interaction when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Terfenadine may lead to a major life threatening interaction when taken with Miconazole and Miconazole may cause a minor interaction that can limit clinical effects when ta... |
DB00005 | DB00073 | 1,057 | 1,394 | [
"DDInter687",
"DDInter1608"
] | Etanercept | Rituximab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Major | 2 | [
[
[
1057,
25,
1394
]
],
[
[
1057,
23,
1114
],
[
1114,
62,
1394
]
],
[
[
1057,
25,
4
],
[
4,
63,
1394
]
],
[
[
1057,
24,
151
],
[
151,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rituximab"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulfat... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Rituximab
Etanercept may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omaceta... |
DB00041 | DB00341 | 1,648 | 1,242 | [
"DDInter38",
"DDInter343"
] | Aldesleukin | Cetirizine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
1648,
24,
1242
]
],
[
[
1648,
24,
537
],
[
537,
63,
1242
]
],
[
[
1648,
24,
905
],
[
905,
24,
1242
]
],
[
[
1648,
25,
695
],
[
695,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazep... |
DB00022 | DB00175 | 268 | 681 | [
"DDInter1408",
"DDInter1509"
] | Peginterferon alfa-2b | Pravastatin | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Moderate | 1 | [
[
[
268,
24,
681
]
],
[
[
268,
24,
1463
],
[
1463,
40,
681
]
],
[
[
268,
24,
126
],
[
126,
62,
681
]
],
[
[
268,
24,
322
],
[
322,
6... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pravastatin"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lova... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin (Compound) resembles Pravastatin (Compound)
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor intera... |
DB01611 | DB09115 | 1,487 | 505 | [
"DDInter893",
"DDInter559"
] | Hydroxychloroquine | Diiodohydroxyquinoline | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
1487,
24,
505
]
],
[
[
1487,
25,
1593
],
[
1593,
24,
505
]
],
[
[
1487,
63,
467
],
[
467,
24,
505
]
],
[
[
1487,
24,
908
],
[
908,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Simvasta... |
DB00552 | DB10795 | 1,238 | 221 | [
"DDInter1425",
"DDInter1486"
] | Pentostatin | Poliovirus type 1 antigen (formaldehyde inactivated) | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1238,
24,
221
]
],
[
[
1238,
64,
581
],
[
581,
24,
221
]
],
[
[
1238,
63,
599
],
[
599,
24,
221
]
],
[
[
1238,
24,
384
],
[
384,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Pentostatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Pentostatin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Pentostatin may cause a moderate interaction that could exacerbate diseases when tak... |
DB09268 | DB11989 | 1,662 | 1,434 | [
"DDInter1464",
"DDInter183"
] | Picosulfuric acid | Benznidazole | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1662,
24,
1434
]
],
[
[
1662,
24,
148
],
[
148,
63,
1434
]
],
[
[
1662,
63,
1593
],
[
1593,
24,
1434
]
],
[
[
1662,
64,
33
],
[
33,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole and Secnidazole may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Cri... |
DB00400 | DB11799 | 353 | 627 | [
"DDInter843",
"DDInter205"
] | Griseofulvin | Bictegravir | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Moderate | 1 | [
[
[
353,
24,
627
]
],
[
[
353,
24,
1362
],
[
1362,
24,
627
]
],
[
[
353,
24,
466
],
[
466,
63,
627
]
],
[
[
353,
63,
79
],
[
79,
24,... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Dar... |
DB00277 | DB09472 | 1,031 | 1,383 | [
"DDInter1791",
"DDInter1693"
] | Theophylline | Sodium sulfate | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1031,
24,
1383
]
],
[
[
1031,
24,
609
],
[
609,
24,
1383
]
],
[
[
1031,
63,
600
],
[
600,
24,
1383
]
],
[
[
1031,
23,
898
],
[
898,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Fluco... |
DB06650 | DB09498 | 1,500 | 810 | [
"DDInter1324",
"DDInter1715"
] | Ofatumumab | Strontium chloride Sr-89 | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1500,
24,
810
]
],
[
[
1500,
63,
597
],
[
597,
24,
810
]
],
[
[
1500,
24,
1362
],
[
1362,
24,
810
]
],
[
[
1500,
24,
738
],
[
738,
... | [
[
[
"Ofatumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Ofatumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenic... | Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00647 | DB01246 | 675 | 820 | [
"DDInter528",
"DDInter45"
] | Dextropropoxyphene | Alimemazine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
675,
25,
820
]
],
[
[
675,
40,
358
],
[
358,
24,
820
]
],
[
[
675,
25,
104
],
[
104,
40,
820
]
],
[
[
675,
25,
401
],
[
401,
24,... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u} may cause a m... | Dextropropoxyphene (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Dextropropoxyphene may lead to a major life threatening interaction when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine ... |
DB01045 | DB06292 | 463 | 549 | [
"DDInter1590",
"DDInter474"
] | Rifampicin | Dapagliflozin | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Minor | 0 | [
[
[
463,
23,
549
]
],
[
[
463,
24,
1344
],
[
1344,
40,
549
]
],
[
[
463,
6,
8717
],
[
8717,
45,
549
]
],
[
[
463,
64,
467
],
[
467,
... | [
[
[
"Rifampicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Rifampicin (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Dapagliflozin (Compound)
Rifampicin may lead to a major life threatening intera... |
DB01394 | DB11581 | 1,554 | 1,456 | [
"DDInter431",
"DDInter1926"
] | Colchicine | Venetoclax | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1554,
25,
1456
]
],
[
[
1554,
24,
1476
],
[
1476,
63,
1456
]
],
[
[
1554,
63,
86
],
[
86,
24,
1456
]
],
[
[
1554,
24,
1683
],
[
1683,
... | [
[
[
"Colchicine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
"Brigatinib... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Micona... |
DB08901 | DB11932 | 1,468 | 327 | [
"DDInter1492",
"DDInter3"
] | Ponatinib | Abametapir (topical) | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1468,
24,
327
]
],
[
[
1468,
63,
168
],
[
168,
24,
327
]
],
[
[
1468,
25,
283
],
[
283,
63,
327
]
],
[
[
1468,
64,
292
],
[
292,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ponatinib ma... |
DB00564 | DB00650 | 1,236 | 1,147 | [
"DDInter293",
"DDInter1041"
] | Carbamazepine | Leucovorin | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Moderate | 1 | [
[
[
1236,
24,
1147
]
],
[
[
1236,
63,
356
],
[
356,
1,
1147
]
],
[
[
1236,
6,
5912
],
[
5912,
45,
1147
]
],
[
[
1236,
21,
28929
],
[
28929... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leucovorin"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Folic acid"
],
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Folic acid and Folic acid (Compound) resembles Leucovorin (Compound)
Carbamazepine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Leucovorin (Compound)
Carbamazepine (Compound) causes Confusional state (Side Effect... |
DB08904 | DB14783 | 375 | 287 | [
"DDInter342",
"DDInter574"
] | Certolizumab pegol | Diroximel fumarate | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Major | 2 | [
[
[
375,
25,
287
]
],
[
[
375,
64,
1101
],
[
1101,
24,
287
]
],
[
[
375,
25,
812
],
[
812,
24,
287
]
],
[
[
375,
63,
599
],
[
599,
2... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"B... | Certolizumab pegol may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Certolizumab pegol may lead to a major life threatening interaction when taken with Siltuximab and Siltuximab m... |
DB00586 | DB08822 | 1,512 | 911 | [
"DDInter537",
"DDInter156"
] | Diclofenac | Azilsartan medoxomil | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
1512,
24,
911
]
],
[
[
1512,
63,
217
],
[
217,
1,
911
]
],
[
[
1512,
24,
240
],
[
240,
1,
911
]
],
[
[
1512,
21,
28880
],
[
28880,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
]... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Azilsartan medox... |
DB00214 | DB01124 | 1,028 | 1,411 | [
"DDInter1836",
"DDInter1828"
] | Torasemide | Tolbutamide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1028,
24,
1411
]
],
[
[
1028,
24,
959
],
[
959,
40,
1411
]
],
[
[
1028,
6,
10215
],
[
10215,
45,
1411
]
],
[
[
1028,
21,
28680
],
[
28... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Torasemide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tolbutamide (Compound)
Torasemide (Compound) causes Rash (Side Effect) and Rash (Side E... |
DB01005 | DB10989 | 995 | 496 | [
"DDInter894",
"DDInter858"
] | Hydroxyurea | Hepatitis A Vaccine | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
995,
24,
496
]
],
[
[
995,
24,
4
],
[
4,
24,
496
]
],
[
[
995,
63,
147
],
[
147,
24,
496
]
],
[
[
995,
24,
738
],
[
738,
63,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepe... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Hydroxyurea may cause a moderate interaction that could exacerbate disea... |
DB00899 | DB11817 | 411 | 1,259 | [
"DDInter1579",
"DDInter165"
] | Remifentanil | Baricitinib | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
411,
24,
1259
]
],
[
[
411,
1,
1349
],
[
1349,
24,
1259
]
],
[
[
411,
24,
407
],
[
407,
24,
1259
]
],
[
[
411,
63,
475
],
[
475,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Remifentanil",
"{u} (Compound) resembles {v} (Compound)",
"Meperidine"
],
[
"Meperidine",
"{u} may cause a mo... | Remifentanil (Compound) resembles Meperidine (Compound) and Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exac... |
DB14491 | DB15617 | 428 | 174 | [
"DDInter725",
"DDInter724"
] | Ferrous fumarate | Ferric derisomaltose | Used in treatment of iron deficiency anemia. | Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide. Iron deficiency results when iron intake, iron stores, and loss of iron from the body do not adequately support production of erythrocytes, also known as red blood cells. Though it is generally considered non life-threa... | Moderate | 1 | [
[
[
428,
24,
174
]
],
[
[
428,
63,
597
],
[
597,
24,
174
]
],
[
[
428,
64,
1575
],
[
1575,
25,
174
]
],
[
[
428,
63,
597
],
[
597,
2... | [
[
[
"Ferrous fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferric derisomaltose"
]
],
[
[
"Ferrous fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlor... | Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ferric derisomaltose
Ferrous fumarate may lead to a major life threatening interaction when taken with Dime... |
DB01255 | DB08875 | 633 | 1,618 | [
"DDInter1078",
"DDInter262"
] | Lisdexamfetamine | Cabozantinib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
633,
25,
1618
]
],
[
[
633,
62,
112
],
[
112,
23,
1618
]
],
[
[
633,
63,
480
],
[
480,
24,
1618
]
],
[
[
633,
24,
1383
],
[
1383,
... | [
[
[
"Lisdexamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Formo... |
DB00352 | DB01132 | 482 | 1,130 | [
"DDInter1814",
"DDInter1472"
] | Tioguanine | Pioglitazone | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
482,
24,
1130
]
],
[
[
482,
21,
29544
],
[
29544,
60,
1130
]
],
[
[
482,
24,
242
],
[
242,
63,
1130
]
],
[
[
482,
24,
1072
],
[
1072,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Weight increased"
],
[
"Weight increased",
"{u} (Side... | Tioguanine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Pioglitazone (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when ta... |
DB09078 | DB12026 | 1,228 | 791 | [
"DDInter1036",
"DDInter1950"
] | Lenvatinib | Voxilaprevir | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most c... | Moderate | 1 | [
[
[
1228,
24,
791
]
],
[
[
1228,
63,
594
],
[
594,
24,
791
]
],
[
[
1228,
64,
1510
],
[
1510,
24,
791
]
],
[
[
1228,
63,
594
],
[
594,
... | [
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxilaprevir"
]
],
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
],
[
... | Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Voxilaprevir
Lenvatinib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may ... |
DB00095 | DB09073 | 66 | 951 | [
"DDInter623",
"DDInter1379"
] | Efalizumab | Palbociclib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
66,
24,
951
]
],
[
[
66,
24,
496
],
[
496,
63,
951
]
],
[
[
66,
24,
259
],
[
259,
24,
951
]
],
[
[
66,
63,
1184
],
[
1184,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ri... |
DB00023 | DB00635 | 305 | 1,573 | [
"DDInter127",
"DDInter1515"
] | Asparaginase Escherichia coli | Prednisone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
305,
24,
1573
]
],
[
[
305,
24,
175
],
[
175,
40,
1573
]
],
[
[
305,
24,
251
],
[
251,
1,
1573
]
],
[
[
305,
24,
1018
],
[
1018,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamet... |
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