drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB06273 | DB08889 | 980 | 350 | [
"DDInter1824",
"DDInter299"
] | Tocilizumab | Carfilzomib | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
980,
24,
350
]
],
[
[
980,
24,
1270
],
[
1270,
63,
350
]
],
[
[
980,
63,
482
],
[
482,
24,
350
]
],
[
[
980,
24,
310
],
[
310,
2... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified prot... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Tocilizumab may cause a moderate interaction that coul... |
DB00393 | DB06168 | 854 | 1,531 | [
"DDInter1295",
"DDInter281"
] | Nimodipine | Canakinumab | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
854,
24,
1531
]
],
[
[
854,
24,
1476
],
[
1476,
63,
1531
]
],
[
[
854,
24,
1213
],
[
1213,
24,
1531
]
],
[
[
854,
63,
58
],
[
58,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasati... |
DB04946 | DB09082 | 924 | 659 | [
"DDInter907",
"DDInter1934"
] | Iloperidone | Vilanterol | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
924,
24,
659
]
],
[
[
924,
24,
1296
],
[
1296,
63,
659
]
],
[
[
924,
25,
927
],
[
927,
63,
659
]
],
[
[
924,
25,
1069
],
[
1069,
... | [
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
],
... | Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Iloperidone may lead to a major life threatening interaction when taken with Encorafenib and Encora... |
DB00361 | DB00532 | 134 | 208 | [
"DDInter1939",
"DDInter1152"
] | Vinorelbine | Mephenytoin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
134,
24,
208
]
],
[
[
134,
63,
168
],
[
168,
23,
208
]
],
[
[
134,
25,
908
],
[
908,
63,
208
]
],
[
[
134,
63,
599
],
[
599,
24,... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Mephenytoin
Vinorelbine may lead to a major life threatening interaction when taken with Golimumab and Golimumab may cause a... |
DB00652 | DB01183 | 234 | 173 | [
"DDInter1421",
"DDInter1262"
] | Pentazocine | Naloxone | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, ... | Moderate | 1 | [
[
[
234,
24,
173
]
],
[
[
234,
1,
11505
],
[
11505,
40,
173
]
],
[
[
234,
64,
475
],
[
475,
24,
173
]
],
[
[
234,
25,
267
],
[
267,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxone"
]
],
[
[
"Pentazocine",
"{u} (Compound) resembles {v} (Compound)",
"Levallorphan"
],
[
"Levallorphan",
"{u} (Compound) rese... | Pentazocine (Compound) resembles Levallorphan (Compound) and Levallorphan (Compound) resembles Naloxone (Compound)
Pentazocine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone
Pentazocine may l... |
DB00041 | DB01149 | 1,648 | 851 | [
"DDInter38",
"DDInter1274"
] | Aldesleukin | Nefazodone | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
1648,
24,
851
]
],
[
[
1648,
24,
252
],
[
252,
40,
851
]
],
[
[
1648,
24,
1178
],
[
1178,
1,
851
]
],
[
[
1648,
24,
1242
],
[
1242,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Nefazodone (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Nefazodo... |
DB01098 | DB08901 | 14 | 1,468 | [
"DDInter1622",
"DDInter1492"
] | Rosuvastatin | Ponatinib | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
14,
24,
1468
]
],
[
[
14,
6,
10083
],
[
10083,
45,
1468
]
],
[
[
14,
18,
4165
],
[
4165,
46,
1468
]
],
[
[
14,
7,
3163
],
[
3163,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Rosuvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB11"
],
[
"ABCB11",
"{u} (Gene) is bound by {v} (Compound... | Rosuvastatin (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Ponatinib (Compound)
Rosuvastatin (Compound) downregulates EGF (Gene) and EGF (Gene) is upregulated by Ponatinib (Compound)
Rosuvastatin (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Ponatinib (Compound)
Rosuvastatin ... |
DB09098 | DB11979 | 98 | 1,320 | [
"DDInter1700",
"DDInter625"
] | Somatrem | Elagolix | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
98,
24,
1320
]
],
[
[
98,
62,
168
],
[
168,
23,
1320
]
],
[
[
98,
23,
1612
],
[
1612,
23,
1320
]
],
[
[
98,
24,
1297
],
[
1297,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Somatrem",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
"Bor... | Somatrem may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir and Fostemsavir may c... |
DB00206 | DB06292 | 1,245 | 549 | [
"DDInter1582",
"DDInter474"
] | Reserpine | Dapagliflozin | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1245,
24,
549
]
],
[
[
1245,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1245,
6,
4973
],
[
4973,
45,
549
]
],
[
[
1245,
21,
28787
],
[
28787... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Reserpine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dapagliflozin (Compound)
Reserpine (Compound) causes Dermatitis (Side Effect) and D... |
DB00186 | DB00692 | 905 | 274 | [
"DDInter1092",
"DDInter1448"
] | Lorazepam | Phentolamine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
905,
24,
274
]
],
[
[
905,
21,
29118
],
[
29118,
60,
274
]
],
[
[
905,
40,
695
],
[
695,
24,
274
]
],
[
[
905,
24,
530
],
[
530,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Lorazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) is ... | Lorazepam (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Lorazepam (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine
Lorazepam may cause a moderate interacti... |
DB00313 | DB00352 | 556 | 482 | [
"DDInter1913",
"DDInter1814"
] | Valproic acid | Tioguanine | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Moderate | 1 | [
[
[
556,
24,
482
]
],
[
[
556,
21,
28868
],
[
28868,
60,
482
]
],
[
[
556,
24,
322
],
[
322,
63,
482
]
],
[
[
556,
63,
912
],
[
912,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
]
],
[
[
"Valproic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Stomatitis"
],
[
"Stomatitis",
"{u} (Side Effect)... | Valproic acid (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Tioguanine (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00352 | DB06603 | 482 | 39 | [
"DDInter1814",
"DDInter1387"
] | Tioguanine | Panobinostat | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
482,
24,
39
]
],
[
[
482,
24,
1247
],
[
1247,
23,
39
]
],
[
[
482,
63,
912
],
[
912,
24,
39
]
],
[
[
482,
24,
221
],
[
221,
63,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Interfero... |
DB00712 | DB01009 | 1,274 | 935 | [
"DDInter763",
"DDInter1009"
] | Flurbiprofen | Ketoprofen | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1274,
24,
935
]
],
[
[
1274,
40,
253
],
[
253,
1,
935
]
],
[
[
1274,
63,
1523
],
[
1523,
40,
935
]
],
[
[
1274,
1,
11303
],
[
11303,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) resembles {v} (Compound)",
"Mefenamic acid"
],
[
"Mefenamic acid",
"{u} (Compou... | Flurbiprofen (Compound) resembles Mefenamic acid (Compound) and Mefenamic acid (Compound) resembles Ketoprofen (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Flurbiprofen (Compound) resembles Fenb... |
DB00835 | DB01176 | 100 | 537 | [
"DDInter245",
"DDInter453"
] | Brompheniramine | Cyclizine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
100,
24,
537
]
],
[
[
100,
24,
1511
],
[
1511,
63,
537
]
],
[
[
100,
40,
11244
],
[
11244,
1,
537
]
],
[
[
100,
63,
1242
],
[
1242,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Brompheniramine (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Cyclizine... |
DB00264 | DB13142 | 88 | 841 | [
"DDInter1200",
"DDInter274"
] | Metoprolol | Calcium glubionate anhydrous | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
88,
24,
841
]
],
[
[
88,
40,
887
],
[
887,
24,
841
]
],
[
[
88,
23,
1152
],
[
1152,
24,
841
]
],
[
[
88,
1,
819
],
[
819,
24,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Pindolol"
],
[
"Pindolol",
"{u} may c... | Metoprolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Metoprolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate intera... |
DB00557 | DB01611 | 252 | 1,487 | [
"DDInter895",
"DDInter893"
] | Hydroxyzine | Hydroxychloroquine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
252,
25,
1487
]
],
[
[
252,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
252,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
252,
21,
29232
],
[
2923... | [
[
[
"Hydroxyzine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Hydroxyzine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Hydroxyzine (Co... |
DB00065 | DB08904 | 581 | 375 | [
"DDInter923",
"DDInter342"
] | Infliximab | Certolizumab pegol | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
581,
25,
375
]
],
[
[
581,
23,
1461
],
[
1461,
23,
375
]
],
[
[
581,
23,
1193
],
[
1193,
62,
375
]
],
[
[
581,
24,
231
],
[
231,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitam... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zi... |
DB05239 | DB11627 | 866 | 1,367 | [
"DDInter425",
"DDInter860"
] | Cobimetinib | Hepatitis B Vaccine (Recombinant) | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
866,
24,
1367
]
],
[
[
866,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
866,
24,
259
],
[
259,
24,
1367
]
],
[
[
866,
25,
375
],
[
375,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
]... | Cobimetinib may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept ... |
DB00227 | DB09054 | 1,463 | 384 | [
"DDInter1098",
"DDInter905"
] | Lovastatin | Idelalisib | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1463,
25,
384
]
],
[
[
1463,
24,
72
],
[
72,
24,
384
]
],
[
[
1463,
63,
58
],
[
58,
24,
384
]
],
[
[
1463,
64,
600
],
[
600,
24,... | [
[
[
"Lovastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
],
[
"Eltrombop... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefa... |
DB01220 | DB08875 | 1,088 | 1,618 | [
"DDInter1593",
"DDInter262"
] | Rifaximin | Cabozantinib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
1088,
24,
1618
]
],
[
[
1088,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
1088,
24,
165
],
[
165,
24,
1618
]
],
[
[
1088,
40,
690
],
[
690,
... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
],
... | Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Tolvapt... |
DB00939 | DB13620 | 1,338 | 948 | [
"DDInter1135",
"DDInter1499"
] | Meclofenamic acid | Potassium gluconate | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Moderate | 1 | [
[
[
1338,
24,
948
]
],
[
[
1338,
24,
848
],
[
848,
24,
948
]
],
[
[
1338,
74,
1512
],
[
1512,
24,
948
]
],
[
[
1338,
63,
1274
],
[
1274,
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibup... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Meclofenamic acid (Compound) resembles Diclofenac (Compound) and Meclofenamic acid may cause a mod... |
DB08815 | DB12941 | 154 | 466 | [
"DDInter1104",
"DDInter481"
] | Lurasidone | Darolutamide | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
154,
24,
466
]
],
[
[
154,
63,
1374
],
[
1374,
23,
466
]
],
[
[
154,
64,
600
],
[
600,
23,
466
]
],
[
[
154,
25,
351
],
[
351,
2... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Lurasidone may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may ca... |
DB00814 | DB01097 | 1,171 | 1,377 | [
"DDInter1143",
"DDInter1033"
] | Meloxicam | Leflunomide | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1171,
25,
1377
]
],
[
[
1171,
10,
11573
],
[
11573,
44,
1377
]
],
[
[
1171,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
1171,
21,
29231
],
[
... | [
[
[
"Meloxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Meloxicam",
"{u} (Compound) palliates {v} (Disease)",
"systemic scleroderma"
],
[
"systemic scleroderma",
"{u} (Disease) is tre... | Meloxicam (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Leflunomide (Compound)
Meloxicam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Meloxicam (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect... |
DB01067 | DB09104 | 959 | 286 | [
"DDInter826",
"DDInter1118"
] | Glipizide | Magnesium hydroxide | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
959,
24,
286
]
],
[
[
959,
24,
820
],
[
820,
23,
286
]
],
[
[
959,
63,
88
],
[
88,
23,
286
]
],
[
[
959,
24,
1326
],
[
1326,
24,... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and... |
DB00494 | DB00662 | 1,533 | 717 | [
"DDInter646",
"DDInter1873"
] | Entacapone | Trimethobenzamide | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
1533,
24,
717
]
],
[
[
1533,
21,
29648
],
[
29648,
60,
717
]
],
[
[
1533,
63,
1594
],
[
1594,
24,
717
]
],
[
[
1533,
24,
506
],
[
506,... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Entacapone",
"{u} (Compound) causes {v} (Side Effect)",
"Disorientation"
],
[
"Disorientation",
"{u} (Sid... | Entacapone (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when t... |
DB11095 | DB11312 | 235 | 298 | [
"DDInter505",
"DDInter1542"
] | Desirudin | Protein C | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Moderate | 1 | [
[
[
235,
24,
298
]
],
[
[
235,
64,
707
],
[
707,
24,
298
]
],
[
[
235,
24,
321
],
[
321,
63,
298
]
],
[
[
235,
63,
1461
],
[
1461,
2... | [
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
]
],
[
[
"Desirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparoid",
... | Desirudin may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib and Selumetinib may cause a... |
DB00193 | DB14568 | 534 | 982 | [
"DDInter1841",
"DDInter1000"
] | Tramadol | Ivosidenib | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
534,
25,
982
]
],
[
[
534,
23,
112
],
[
112,
23,
982
]
],
[
[
534,
25,
608
],
[
608,
23,
982
]
],
[
[
534,
24,
976
],
[
976,
24,... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Tramadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazole... | Tramadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Tramadol may lead to a major life threatening interaction when taken with Lidocaine and Lidocaine may cause a mi... |
DB00852 | DB06207 | 1,445 | 910 | [
"DDInter1545",
"DDInter1667"
] | Pseudoephedrine | Silodosin | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
1445,
24,
910
]
],
[
[
1445,
6,
5214
],
[
5214,
45,
910
]
],
[
[
1445,
21,
28921
],
[
28921,
60,
910
]
],
[
[
1445,
24,
1450
],
[
1450... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Co... | Pseudoephedrine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Silodosin (Compound)
Pseudoephedrine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Silodosin (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Empagl... |
DB00289 | DB12332 | 847 | 1,619 | [
"DDInter132",
"DDInter1626"
] | Atomoxetine | Rucaparib | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
847,
24,
1619
]
],
[
[
847,
23,
222
],
[
222,
23,
1619
]
],
[
[
847,
40,
307
],
[
307,
23,
1619
]
],
[
[
847,
24,
1662
],
[
1662,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Atomoxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Atomoxetine (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit c... |
DB00400 | DB15233 | 353 | 1,650 | [
"DDInter843",
"DDInter142"
] | Griseofulvin | Avapritinib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
353,
24,
1650
]
],
[
[
353,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
353,
62,
1101
],
[
1101,
24,
1650
]
],
[
[
353,
24,
1409
],
[
1409,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexar... |
DB01244 | DB12364 | 762 | 1,421 | [
"DDInter192",
"DDInter200"
] | Bepridil | Betrixaban | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
762,
25,
1421
]
],
[
[
762,
24,
1476
],
[
1476,
24,
1421
]
],
[
[
762,
25,
1151
],
[
1151,
24,
1421
]
],
[
[
762,
64,
888
],
[
888,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
... | Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Bepridil may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a mode... |
DB00470 | DB00776 | 530 | 1,335 | [
"DDInter601",
"DDInter1360"
] | Dronabinol | Oxcarbazepine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
530,
24,
1335
]
],
[
[
530,
24,
1605
],
[
1605,
1,
1335
]
],
[
[
530,
24,
1264
],
[
1264,
63,
1335
]
],
[
[
530,
63,
902
],
[
902,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could ex... |
DB00069 | DB08826 | 367 | 1,292 | [
"DDInter946",
"DDInter489"
] | Interferon alfacon-1 | Deferiprone | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
367,
25,
1292
]
],
[
[
367,
24,
45
],
[
45,
24,
1292
]
],
[
[
367,
25,
72
],
[
72,
24,
1292
]
],
[
[
367,
24,
482
],
[
482,
25,
... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
],
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Interferon alfacon-1 may lead to a major life threatening interaction when taken with Eltrombopag and... |
DB00366 | DB00674 | 1,594 | 1,516 | [
"DDInter600",
"DDInter802"
] | Doxylamine | Galantamine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
1594,
24,
1516
]
],
[
[
1594,
63,
475
],
[
475,
40,
1516
]
],
[
[
1594,
24,
828
],
[
828,
40,
1516
]
],
[
[
1594,
21,
28766
],
[
28766... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine (Compound) resembles Galantamine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Galantamine (Compound)
Doxy... |
DB04946 | DB06282 | 924 | 516 | [
"DDInter907",
"DDInter1053"
] | Iloperidone | Levocetirizine | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
924,
24,
516
]
],
[
[
924,
63,
701
],
[
701,
24,
516
]
],
[
[
924,
40,
1664
],
[
1664,
24,
516
]
],
[
[
924,
24,
407
],
[
407,
6... | [
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Iloperidone (Compound) resembles Risperidone (Compound) and Risperidone may cause a moderate interaction th... |
DB01024 | DB11248 | 1,096 | 1,193 | [
"DDInter1252",
"DDInter1965"
] | Mycophenolic acid | Zinc gluconate | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
1096,
23,
1193
]
],
[
[
1096,
24,
1531
],
[
1531,
23,
1193
]
],
[
[
1096,
23,
1596
],
[
1596,
23,
1193
]
],
[
[
1096,
24,
270
],
[
270... | [
[
[
"Mycophenolic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Iron ... |
DB00367 | DB01132 | 566 | 1,130 | [
"DDInter1061",
"DDInter1472"
] | Levonorgestrel | Pioglitazone | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Minor | 0 | [
[
[
566,
23,
1130
]
],
[
[
566,
6,
8374
],
[
8374,
45,
1130
]
],
[
[
566,
7,
4698
],
[
4698,
46,
1130
]
],
[
[
566,
18,
1870
],
[
1870,
... | [
[
[
"Levonorgestrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pioglitazone"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Levonorgestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pioglitazone (Compound)
Levonorgestrel (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Pioglitazone (Compound)
Levonorgestrel (Compound) downregulates MYC (Gene) and MYC (Gene) is upregulated by Pioglitazone (Compound)
Levo... |
DB00843 | DB01114 | 479 | 272 | [
"DDInter583",
"DDInter362"
] | Donepezil | Chlorpheniramine | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
479,
24,
272
]
],
[
[
479,
24,
849
],
[
849,
63,
272
]
],
[
[
479,
63,
128
],
[
128,
24,
272
]
],
[
[
479,
6,
12523
],
[
12523,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramin... |
DB00712 | DB00790 | 1,274 | 664 | [
"DDInter763",
"DDInter1431"
] | Flurbiprofen | Perindopril | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
1274,
24,
664
]
],
[
[
1274,
63,
1638
],
[
1638,
1,
664
]
],
[
[
1274,
24,
954
],
[
954,
40,
664
]
],
[
[
1274,
18,
5833
],
[
5833,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Co... |
DB00331 | DB12015 | 1,645 | 1,033 | [
"DDInter1164",
"DDInter53"
] | Metformin | Alpelisib | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1645,
24,
1033
]
],
[
[
1645,
24,
1254
],
[
1254,
24,
1033
]
],
[
[
1645,
63,
1028
],
[
1028,
24,
1033
]
],
[
[
1645,
24,
1619
],
[
16... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Torasemide... |
DB00323 | DB04837 | 1,062 | 649 | [
"DDInter1829",
"DDInter407"
] | Tolcapone | Clofedanol | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1062,
24,
649
]
],
[
[
1062,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1062,
24,
832
],
[
832,
40,
649
]
],
[
[
1062,
63,
701
],
[
701,
... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamin... |
DB00215 | DB00470 | 1,230 | 530 | [
"DDInter388",
"DDInter601"
] | Citalopram | Dronabinol | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1230,
24,
530
]
],
[
[
1230,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
530
]
],
[
[
1230,
21,
29226
],
[
29226... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dronabinol (Compound)
Citalopram (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side... |
DB00060 | DB00520 | 912 | 1,358 | [
"DDInter947",
"DDInter306"
] | Interferon beta-1a | Caspofungin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Moderate | 1 | [
[
[
912,
24,
1358
]
],
[
[
912,
24,
267
],
[
267,
63,
1358
]
],
[
[
912,
24,
482
],
[
482,
24,
1358
]
],
[
[
912,
63,
1560
],
[
1560,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caspofungin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Caspofungin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Tiog... |
DB00099 | DB16582 | 440 | 899 | [
"DDInter735",
"DDInter1080"
] | Filgrastim | Lisocabtagene maraleucel | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Lisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to [brexucabtagene autoleucel] and [axicabtagene ciloleucel].[A228493,L31588] Lisocabtagene maraleucel is a genetically modified autologous T-cell therapy that targets CD19, the B-lymphocyte surface antigen B4. CAR T-cell therapy has ... | Moderate | 1 | [
[
[
440,
24,
899
]
],
[
[
440,
24,
869
],
[
869,
24,
899
]
],
[
[
440,
24,
869
],
[
869,
24,
810
],
[
810,
24,
899
]
],
[
[
440,
24,... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisocabtagene maraleucel"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Lisocabtagene maraleucel
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Topotecan... |
DB00334 | DB09074 | 867 | 1,362 | [
"DDInter1326",
"DDInter1327"
] | Olanzapine | Olaparib | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
867,
24,
1362
]
],
[
[
867,
24,
79
],
[
79,
24,
1362
]
],
[
[
867,
24,
1619
],
[
1619,
63,
1362
]
],
[
[
867,
63,
702
],
[
702,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib m... |
DB00612 | DB08884 | 1,121 | 796 | [
"DDInter216",
"DDInter800"
] | Bisoprolol | Gadoxetic acid | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up ... | Moderate | 1 | [
[
[
1121,
24,
796
]
],
[
[
1121,
63,
457
],
[
457,
1,
796
]
],
[
[
1121,
24,
1106
],
[
1106,
1,
796
]
],
[
[
1121,
21,
28841
],
[
28841,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoxetic acid"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadodiamide"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadoxetic acid (Compound)
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Gadofosveset trisodium and Gadofosveset trisodium (Compound) re... |
DB06176 | DB13074 | 1,342 | 877 | [
"DDInter1616",
"DDInter1110"
] | Romidepsin | Macimorelin | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1342,
25,
877
]
],
[
[
1342,
62,
112
],
[
112,
23,
877
]
],
[
[
1342,
63,
651
],
[
651,
24,
877
]
],
[
[
1342,
24,
913
],
[
913,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and F... |
DB01159 | DB11130 | 419 | 407 | [
"DDInter854",
"DDInter1344"
] | Halothane | Opium | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
419,
24,
407
]
],
[
[
419,
63,
770
],
[
770,
24,
407
]
],
[
[
419,
24,
1662
],
[
1662,
24,
407
]
],
[
[
419,
23,
256
],
[
256,
2... | [
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
],
[
"T... | Halothane may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Opium
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Pico... |
DB00595 | DB01357 | 1,545 | 890 | [
"DDInter1374",
"DDInter1160"
] | Oxytetracycline | Mestranol | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
1545,
24,
890
]
],
[
[
1545,
40,
1572
],
[
1572,
24,
890
]
],
[
[
1545,
24,
126
],
[
126,
24,
890
]
],
[
[
1545,
24,
1096
],
[
1096,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Oxytetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
"{u} ma... | Oxytetracycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Mestranol
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interacti... |
DB00867 | DB06292 | 1,052 | 549 | [
"DDInter1606",
"DDInter474"
] | Ritodrine | Dapagliflozin | Adrenergic beta-agonist used to control premature labor. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1052,
24,
549
]
],
[
[
1052,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1052,
63,
79
],
[
79,
23,
549
]
],
[
[
1052,
63,
1636
],
[
1636,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a minor interaction that can... |
DB00836 | DB04908 | 543 | 1,671 | [
"DDInter1088",
"DDInter741"
] | Loperamide | Flibanserin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Major | 2 | [
[
[
543,
25,
1671
]
],
[
[
543,
24,
741
],
[
741,
63,
1671
]
],
[
[
543,
24,
830
],
[
830,
24,
1671
]
],
[
[
543,
63,
1594
],
[
1594,
... | [
[
[
"Loperamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flibanserin"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
[
"Rolapitan... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phe... |
DB00531 | DB00552 | 450 | 1,238 | [
"DDInter456",
"DDInter1425"
] | Cyclophosphamide | Pentostatin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
450,
24,
1238
]
],
[
[
450,
21,
28769
],
[
28769,
60,
1238
]
],
[
[
450,
62,
1467
],
[
1467,
23,
1238
]
],
[
[
450,
23,
1539
],
[
1539... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
... | Cyclophosphamide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Pentostatin (Compound)
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin may cause a minor interaction that can limit clinical effects when... |
DB01024 | DB09050 | 1,096 | 931 | [
"DDInter1252",
"DDInter333"
] | Mycophenolic acid | Ceftolozane | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Ceftolozane is a semi-synthetic broad-spectrum fifth generation cephalosporin. It was approved by the FDA in 2014 for use in combination with [Tazobactam] for the treatment of serious infections, such as intra-abdominal infections and complicated urinary tract infections. The manufacturer of this drug is Cubist Pharmac... | Moderate | 1 | [
[
[
1096,
24,
931
]
],
[
[
1096,
63,
361
],
[
361,
24,
931
]
],
[
[
1096,
24,
1448
],
[
1448,
24,
931
]
],
[
[
1096,
63,
361
],
[
361,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftolozane"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Ceftolozane
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Streptomyc... |
DB00361 | DB00615 | 134 | 690 | [
"DDInter1939",
"DDInter1589"
] | Vinorelbine | Rifabutin | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
134,
24,
690
]
],
[
[
134,
24,
463
],
[
463,
1,
690
]
],
[
[
134,
6,
8374
],
[
8374,
45,
690
]
],
[
[
134,
21,
29062
],
[
29062,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
[
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Vinorelbine (Compound) causes Neutropenia (Side Effect) and Neutro... |
DB00795 | DB09133 | 50 | 1,527 | [
"DDInter1725",
"DDInter965"
] | Sulfasalazine | Iothalamic acid | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
50,
25,
1527
]
],
[
[
50,
24,
116
],
[
116,
63,
1527
]
],
[
[
50,
63,
589
],
[
589,
25,
1527
]
],
[
[
50,
24,
1329
],
[
1329,
25... | [
[
[
"Sulfasalazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
],
[
... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131 and Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Cispla... |
DB00694 | DB01059 | 51 | 956 | [
"DDInter485",
"DDInter1313"
] | Daunorubicin | Norfloxacin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
51,
24,
956
]
],
[
[
51,
24,
872
],
[
872,
40,
956
]
],
[
[
51,
64,
1176
],
[
1176,
1,
956
]
],
[
[
51,
24,
1539
],
[
1539,
1,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Daunorubicin may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
D... |
DB00776 | DB09039 | 1,335 | 1,670 | [
"DDInter1360",
"DDInter629"
] | Oxcarbazepine | Eliglustat | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
1335,
24,
1670
]
],
[
[
1335,
24,
1135
],
[
1135,
62,
1670
]
],
[
[
1335,
24,
1409
],
[
1409,
24,
1670
]
],
[
[
1335,
40,
1164
],
[
11... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixab... |
DB01041 | DB10583 | 770 | 949 | [
"DDInter1789",
"DDInter415"
] | Thalidomide | Clostridium tetani toxoid antigen (formaldehyde inactivated) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
770,
24,
949
]
],
[
[
770,
64,
550
],
[
550,
24,
949
]
],
[
[
770,
25,
1377
],
[
1377,
24,
949
]
],
[
[
770,
63,
58
],
[
58,
24,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}... | Thalidomide may lead to a major life threatening interaction when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Thalidomide may lead to a major life threatening interaction when taken wi... |
DB06616 | DB11581 | 594 | 1,456 | [
"DDInter224",
"DDInter1926"
] | Bosutinib | Venetoclax | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
594,
24,
1456
]
],
[
[
594,
63,
536
],
[
536,
24,
1456
]
],
[
[
594,
24,
241
],
[
241,
63,
1456
]
],
[
[
594,
25,
1375
],
[
1375,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib and Erd... |
DB00850 | DB06699 | 1,630 | 774 | [
"DDInter1432",
"DDInter493"
] | Perphenazine | Degarelix | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
1630,
24,
774
]
],
[
[
1630,
63,
521
],
[
521,
1,
774
]
],
[
[
1630,
21,
29232
],
[
29232,
60,
774
]
],
[
[
1630,
23,
112
],
[
112,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Perphenazine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Perphenazine may cause a minor interaction t... |
DB00004 | DB10316 | 669 | 334 | [
"DDInter499",
"DDInter1248"
] | Denileukin diftitox | Mumps virus strain B level jeryl lynn live antigen | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
669,
25,
334
]
],
[
[
669,
25,
1057
],
[
1057,
25,
334
]
],
[
[
669,
24,
599
],
[
599,
25,
334
]
],
[
[
669,
25,
1259
],
[
1259,
... | [
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Denileukin diftitox may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when take... |
DB00687 | DB00749 | 870 | 59 | [
"DDInter747",
"DDInter699"
] | Fludrocortisone | Etodolac | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
870,
24,
59
]
],
[
[
870,
21,
28748
],
[
28748,
60,
59
]
],
[
[
870,
1,
175
],
[
175,
24,
59
]
],
[
[
870,
63,
245
],
[
245,
24,... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Vertigo"
],
[
"Vertigo",
"{u} (Side Effect) is ... | Fludrocortisone (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Etodolac (Compound)
Fludrocortisone (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Fludrocortisone may cause a moderate... |
DB00959 | DB10583 | 1,486 | 949 | [
"DDInter1191",
"DDInter415"
] | Methylprednisolone | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1486,
24,
949
]
],
[
[
1486,
63,
589
],
[
589,
24,
949
]
],
[
[
1486,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1486,
25,
1259
],
[
1259,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Methylprednisolone may lead to a major life threatening ... |
DB00372 | DB00731 | 999 | 1,144 | [
"DDInter1793",
"DDInter1269"
] | Thiethylperazine | Nateglinide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
999,
24,
1144
]
],
[
[
999,
63,
80
],
[
80,
40,
1144
]
],
[
[
999,
24,
93
],
[
93,
40,
1144
]
],
[
[
999,
24,
610
],
[
610,
24,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Nateglinide (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Dextroamphetamine and Dextroamphetamine (Compound) res... |
DB11730 | DB14409 | 351 | 1,129 | [
"DDInter1588",
"DDInter867"
] | Ribociclib | Human adenovirus e serotype 4 strain cl-68578 antigen | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
351,
24,
1129
]
],
[
[
351,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
351,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
351,
24,
119
],
[
119,
... | [
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Ribociclib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Ribociclib may cause a moderate interaction that could exacerbate diseases when take... |
DB00063 | DB08875 | 366 | 1,618 | [
"DDInter659",
"DDInter262"
] | Eptifibatide | Cabozantinib | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
366,
25,
1618
]
],
[
[
366,
24,
41
],
[
41,
63,
1618
]
],
[
[
366,
24,
222
],
[
222,
24,
1618
]
],
[
[
366,
24,
885
],
[
885,
25... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
... | Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Sibut... |
DB00543 | DB06699 | 87 | 774 | [
"DDInter82",
"DDInter493"
] | Amoxapine | Degarelix | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
87,
24,
774
]
],
[
[
87,
63,
521
],
[
521,
1,
774
]
],
[
[
87,
21,
29232
],
[
29232,
60,
774
]
],
[
[
87,
23,
112
],
[
112,
23,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Amoxapine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Amoxapine may cause a minor interaction that can l... |
DB01599 | DB08881 | 1,232 | 868 | [
"DDInter1523",
"DDInter1925"
] | Probucol | Vemurafenib | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1232,
25,
868
]
],
[
[
1232,
62,
112
],
[
112,
23,
868
]
],
[
[
1232,
63,
480
],
[
480,
24,
868
]
],
[
[
1232,
24,
286
],
[
286,
... | [
[
[
"Probucol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Probucol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formote... |
DB00424 | DB01209 | 19 | 1,359 | [
"DDInter896",
"DDInter531"
] | Hyoscyamine | Dezocine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
19,
24,
1359
]
],
[
[
19,
24,
234
],
[
234,
1,
1359
]
],
[
[
19,
24,
262
],
[
262,
24,
1359
]
],
[
[
19,
63,
1594
],
[
1594,
24,... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could... |
DB00208 | DB00945 | 1,018 | 1,479 | [
"DDInter1804",
"DDInter20"
] | Ticlopidine | Acetylsalicylic acid | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1018,
24,
1479
]
],
[
[
1018,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
1018,
6,
10215
],
[
10215,
45,
1479
]
],
[
[
1018,
21,
28931
],
[
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic ac... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Ticlopidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicy... |
DB01265 | DB06317 | 1,477 | 1,626 | [
"DDInter1757",
"DDInter630"
] | Telbivudine | Elotuzumab | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
1477,
24,
1626
]
],
[
[
1477,
63,
973
],
[
973,
24,
1626
]
],
[
[
1477,
24,
310
],
[
310,
63,
1626
]
],
[
[
1477,
64,
367
],
[
367,
... | [
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cab... |
DB09073 | DB12010 | 951 | 214 | [
"DDInter1379",
"DDInter785"
] | Palbociclib | Fostamatinib | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
951,
24,
214
]
],
[
[
951,
64,
976
],
[
976,
24,
214
]
],
[
[
951,
63,
723
],
[
723,
24,
214
]
],
[
[
951,
24,
861
],
[
861,
63,... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Palbociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofac... | Palbociclib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ... |
DB00794 | DB11979 | 759 | 1,320 | [
"DDInter1521",
"DDInter625"
] | Primidone | Elagolix | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
759,
24,
1320
]
],
[
[
759,
64,
168
],
[
168,
23,
1320
]
],
[
[
759,
62,
608
],
[
608,
23,
1320
]
],
[
[
759,
25,
1297
],
[
1297,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
... | Primidone may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Primidone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor in... |
DB00934 | DB11186 | 413 | 1,609 | [
"DDInter1124",
"DDInter1427"
] | Maprotiline | Pentoxyverine | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
413,
24,
1609
]
],
[
[
413,
63,
104
],
[
104,
24,
1609
]
],
[
[
413,
24,
649
],
[
649,
24,
1609
]
],
[
[
413,
1,
1302
],
[
1302,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol a... |
DB00704 | DB08868 | 267 | 1,011 | [
"DDInter1263",
"DDInter737"
] | Naltrexone | Fingolimod | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
267,
24,
1011
]
],
[
[
267,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
267,
24,
1247
],
[
1247,
23,
1011
]
],
[
[
267,
24,
242
],
[
242,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Naltrexone",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
... | Naltrexone (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limi... |
DB00014 | DB01182 | 521 | 371 | [
"DDInter839",
"DDInter1534"
] | Goserelin | Propafenone | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
521,
24,
371
]
],
[
[
521,
24,
847
],
[
847,
1,
371
]
],
[
[
521,
24,
675
],
[
675,
40,
371
]
],
[
[
521,
24,
455
],
[
455,
24,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Propa... |
DB00373 | DB08938 | 461 | 1,384 | [
"DDInter1809",
"DDInter1112"
] | Timolol | Magaldrate | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
461,
23,
1384
]
],
[
[
461,
24,
167
],
[
167,
23,
1384
]
],
[
[
461,
63,
245
],
[
245,
24,
1384
]
],
[
[
461,
24,
478
],
[
478,
... | [
[
[
"Timolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glime... |
DB00731 | DB08886 | 1,144 | 637 | [
"DDInter1269",
"DDInter126"
] | Nateglinide | Asparaginase Erwinia chrysanthemi | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1144,
24,
637
]
],
[
[
1144,
24,
167
],
[
167,
24,
637
]
],
[
[
1144,
24,
1385
],
[
1385,
63,
637
]
],
[
[
1144,
63,
1274
],
[
1274,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hy... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Nateglinide may cause a moderate interaction that could exacerbate diseases when... |
DB00563 | DB01284 | 663 | 1,042 | [
"DDInter1174",
"DDInter1782"
] | Methotrexate | Tetracosactide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
663,
24,
1042
]
],
[
[
663,
24,
1683
],
[
1683,
63,
1042
]
],
[
[
663,
63,
811
],
[
811,
24,
1042
]
],
[
[
663,
25,
1137
],
[
1137,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Metolazone ... |
DB00238 | DB00342 | 188 | 1,181 | [
"DDInter1285",
"DDInter1770"
] | Nevirapine | Terfenadine | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Moderate | 1 | [
[
[
188,
24,
1181
]
],
[
[
188,
24,
159
],
[
159,
63,
1181
]
],
[
[
188,
25,
1476
],
[
1476,
63,
1181
]
],
[
[
188,
23,
1101
],
[
1101,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine
Nevirapine may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may... |
DB00313 | DB00631 | 556 | 372 | [
"DDInter1913",
"DDInter405"
] | Valproic acid | Clofarabine | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
556,
24,
372
]
],
[
[
556,
21,
28903
],
[
28903,
60,
372
]
],
[
[
556,
63,
1560
],
[
1560,
24,
372
]
],
[
[
556,
24,
292
],
[
292,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Valproic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Dry skin"
],
[
"Dry skin",
"{u} (Side Effect) is... | Valproic acid (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Clofarabine (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01177 | DB01246 | 77 | 820 | [
"DDInter904",
"DDInter45"
] | Idarubicin | Alimemazine | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
77,
24,
820
]
],
[
[
77,
63,
401
],
[
401,
24,
820
]
],
[
[
77,
63,
675
],
[
675,
25,
820
]
],
[
[
77,
63,
508
],
[
508,
1,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphe... |
DB00011 | DB01100 | 1,451 | 1,568 | [
"DDInter944",
"DDInter1470"
] | Interferon alfa-n1 | Pimozide | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
1451,
24,
1568
]
],
[
[
1451,
24,
112
],
[
112,
23,
1568
]
],
[
[
1451,
24,
1503
],
[
1503,
24,
1568
]
],
[
[
1451,
63,
491
],
[
491,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimozide
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Lin... |
DB00393 | DB00501 | 854 | 752 | [
"DDInter1295",
"DDInter380"
] | Nimodipine | Cimetidine | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
854,
24,
752
]
],
[
[
854,
6,
8374
],
[
8374,
45,
752
]
],
[
[
854,
21,
28784
],
[
28784,
60,
752
]
],
[
[
854,
25,
1166
],
[
1166,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Nimodipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Nimodipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cimetidine (Compound)
Nimodipine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Cimetidine (Compound)
Nimodipine may lead to a major life threatening interaction when taken with Dolasetron and Dolas... |
DB00078 | DB01166 | 1,172 | 477 | [
"DDInter898",
"DDInter379"
] | Ibritumomab tiuxetan | Cilostazol | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
1172,
25,
477
]
],
[
[
1172,
25,
126
],
[
126,
23,
477
]
],
[
[
1172,
23,
539
],
[
539,
62,
477
]
],
[
[
1172,
24,
109
],
[
109,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfari... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum ma... |
DB01242 | DB08896 | 1,237 | 292 | [
"DDInter410",
"DDInter1576"
] | Clomipramine | Regorafenib | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
1237,
24,
292
]
],
[
[
1237,
63,
79
],
[
79,
1,
292
]
],
[
[
1237,
6,
8374
],
[
8374,
45,
292
]
],
[
[
1237,
21,
28890
],
[
28890,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Clomipramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Regorafenib (Compound)
Clomipramine (Compound) causes Myocardial infarction (Side Eff... |
DB00065 | DB00911 | 581 | 458 | [
"DDInter923",
"DDInter1811"
] | Infliximab | Tinidazole | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
581,
24,
458
]
],
[
[
581,
24,
112
],
[
112,
1,
458
]
],
[
[
581,
24,
238
],
[
238,
24,
458
]
],
[
[
581,
25,
310
],
[
310,
63,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol and Ethambutol may cause a moderate interaction that... |
DB00193 | DB04843 | 534 | 1,511 | [
"DDInter1841",
"DDInter1149"
] | Tramadol | Mepenzolate | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
534,
24,
1511
]
],
[
[
534,
24,
537
],
[
537,
24,
1511
]
],
[
[
534,
24,
649
],
[
649,
1,
1511
]
],
[
[
534,
6,
2720
],
[
2720,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol ... |
DB01244 | DB08895 | 762 | 976 | [
"DDInter192",
"DDInter1825"
] | Bepridil | Tofacitinib | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
762,
24,
976
]
],
[
[
762,
25,
982
],
[
982,
63,
976
]
],
[
[
762,
63,
86
],
[
86,
24,
976
]
],
[
[
762,
24,
407
],
[
407,
63,
... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib",
... | Bepridil may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole may cause a m... |
DB01157 | DB10343 | 304 | 962 | [
"DDInter1875",
"DDInter160"
] | Trimetrexate | Bacillus calmette-guerin substrain tice live antigen | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
304,
25,
962
]
],
[
[
304,
64,
1057
],
[
1057,
25,
962
]
],
[
[
304,
24,
270
],
[
270,
64,
962
]
],
[
[
304,
63,
663
],
[
663,
2... | [
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"... | Trimetrexate may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Ocrel... |
DB00307 | DB00342 | 1,101 | 1,181 | [
"DDInter202",
"DDInter1770"
] | Bexarotene | Terfenadine | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Moderate | 1 | [
[
[
1101,
24,
1181
]
],
[
[
1101,
24,
159
],
[
159,
63,
1181
]
],
[
[
1101,
23,
555
],
[
555,
63,
1181
]
],
[
[
1101,
25,
971
],
[
971,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant and N... |
DB09104 | DB14491 | 286 | 428 | [
"DDInter1118",
"DDInter725"
] | Magnesium hydroxide | Ferrous fumarate | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
286,
24,
428
]
],
[
[
286,
63,
1096
],
[
1096,
23,
428
]
],
[
[
286,
62,
752
],
[
752,
23,
428
]
],
[
[
286,
63,
1008
],
[
1008,
... | [
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Myc... | Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Magnesium hydroxide may cause a minor interaction that can limit clinical effects whe... |
DB00553 | DB12329 | 92 | 464 | [
"DDInter1177",
"DDInter660"
] | Methoxsalen | Eravacycline | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive aerobic, and facultative bacteria. This includes most of those bacteria resistant to cephalosporins, fluoroquin... | Moderate | 1 | [
[
[
92,
24,
464
]
],
[
[
92,
24,
1517
],
[
1517,
25,
464
]
],
[
[
92,
63,
1101
],
[
1101,
25,
464
]
],
[
[
92,
25,
213
],
[
213,
25,... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eravacycline"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
],
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Eravacycline
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene ma... |
DB00620 | DB08880 | 175 | 1,510 | [
"DDInter1855",
"DDInter1771"
] | Triamcinolone | Teriflunomide | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
175,
25,
1510
]
],
[
[
175,
62,
1461
],
[
1461,
23,
1510
]
],
[
[
175,
23,
1193
],
[
1193,
62,
1510
]
],
[
[
175,
24,
221
],
[
221,
... | [
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Triamcinolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vita... | Triamcinolone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Triamcinolone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Z... |
DB01284 | DB11124 | 1,042 | 209 | [
"DDInter1782",
"DDInter1560"
] | Tetracosactide | Racepinephrine | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Minor | 0 | [
[
[
1042,
23,
209
]
],
[
[
1042,
62,
688
],
[
688,
24,
209
]
],
[
[
1042,
23,
659
],
[
659,
24,
209
]
],
[
[
1042,
62,
688
],
[
688,
... | [
[
[
"Tetracosactide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Racepinephrine"
]
],
[
[
"Tetracosactide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salbutamol"
],
... | Tetracosactide may cause a minor interaction that can limit clinical effects when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Racepinephrine
Tetracosactide may cause a minor interaction that can limit clinical effects when taken with Vilanterol an... |
DB00557 | DB08881 | 252 | 868 | [
"DDInter895",
"DDInter1925"
] | Hydroxyzine | Vemurafenib | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
252,
25,
868
]
],
[
[
252,
6,
12523
],
[
12523,
45,
868
]
],
[
[
252,
21,
28681
],
[
28681,
60,
868
]
],
[
[
252,
23,
112
],
[
112,
... | [
[
[
"Hydroxyzine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Vemu... | Hydroxyzine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Vemurafenib (Compound)
Hydroxyzine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Vemurafenib (Compound)
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Me... |
DB00712 | DB09133 | 1,274 | 1,527 | [
"DDInter763",
"DDInter965"
] | Flurbiprofen | Iothalamic acid | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
1274,
25,
1527
]
],
[
[
1274,
63,
863
],
[
863,
24,
1527
]
],
[
[
1274,
24,
762
],
[
762,
24,
1527
]
],
[
[
1274,
24,
242
],
[
242,
... | [
[
[
"Flurbiprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiloride"
],
[
"Am... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Amiloride and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Bepridil and B... |
DB00055 | DB00712 | 834 | 1,274 | [
"DDInter605",
"DDInter763"
] | Drotrecogin alfa | Flurbiprofen | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Major | 2 | [
[
[
834,
25,
1274
]
],
[
[
834,
25,
935
],
[
935,
63,
1274
]
],
[
[
834,
24,
529
],
[
529,
24,
1274
]
],
[
[
834,
24,
643
],
[
643,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
],
[
"Ketoprofen"... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvox... |
DB00682 | DB00930 | 126 | 166 | [
"DDInter1951",
"DDInter432"
] | Warfarin | Colesevelam | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | Moderate | 1 | [
[
[
126,
24,
166
]
],
[
[
126,
24,
959
],
[
959,
63,
166
]
],
[
[
126,
63,
1645
],
[
1645,
24,
166
]
],
[
[
126,
24,
167
],
[
167,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colesevelam"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin ma... |
DB05294 | DB06663 | 1,069 | 1,154 | [
"DDInter1917",
"DDInter1398"
] | Vandetanib | Pasireotide | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1069,
25,
1154
]
],
[
[
1069,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1069,
62,
112
],
[
112,
23,
1154
]
],
[
[
1069,
63,
62
],
[
62,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Vandetanib",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused b... | Vandetanib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
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