drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00726 | DB00747 | 1,164 | 1,442 | [
"DDInter1876",
"DDInter1647"
] | Trimipramine | Scopolamine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1164,
24,
1442
]
],
[
[
1164,
63,
19
],
[
19,
24,
1442
]
],
[
[
1164,
6,
4973
],
[
4973,
45,
1442
]
],
[
[
1164,
21,
28766
],
[
28766,... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Trimipramine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Scopolamine (Compound)
Trimipramine... |
DB00934 | DB04837 | 413 | 649 | [
"DDInter1124",
"DDInter407"
] | Maprotiline | Clofedanol | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
413,
24,
649
]
],
[
[
413,
24,
1376
],
[
1376,
24,
649
]
],
[
[
413,
1,
293
],
[
293,
40,
649
]
],
[
[
413,
63,
832
],
[
832,
40... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Maprotiline (Compound) resembles Imipramine (Compound) and Imipramine (Compound) resembles Clofedanol... |
DB00679 | DB00694 | 684 | 51 | [
"DDInter1796",
"DDInter485"
] | Thioridazine | Daunorubicin | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Major | 2 | [
[
[
684,
25,
51
]
],
[
[
684,
6,
7950
],
[
7950,
45,
51
]
],
[
[
684,
7,
8617
],
[
8617,
45,
51
]
],
[
[
684,
7,
9072
],
[
9072,
46,... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daunorubicin"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"D... | Thioridazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Daunorubicin (Compound)
Thioridazine (Compound) upregulates POR (Gene) and POR (Gene) is bound by Daunorubicin (Compound)
Thioridazine (Compound) upregulates TMEM140 (Gene) and TMEM140 (Gene) is upregulated by Daunorubicin (Compound)
Thioridazine... |
DB00969 | DB01087 | 2 | 1,520 | [
"DDInter52",
"DDInter1520"
] | Alosetron | Primaquine | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
2,
24,
1520
]
],
[
[
2,
6,
7950
],
[
7950,
45,
1520
]
],
[
[
2,
21,
28722
],
[
28722,
60,
1520
]
],
[
[
2,
24,
1297
],
[
1297,
6... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Alosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Alosetron (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Primaquine (Compound)
Alosetron (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Primaquine (Compound)
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrosta... |
DB00073 | DB00363 | 1,394 | 695 | [
"DDInter1608",
"DDInter419"
] | Rituximab | Clozapine | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
1394,
25,
695
]
],
[
[
1394,
24,
738
],
[
738,
64,
695
]
],
[
[
1394,
25,
507
],
[
507,
64,
695
]
],
[
[
1394,
64,
1057
],
[
1057,
... | [
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
"Niraparib",
... | Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may lead to a major life threatening interaction when taken with Clozapine
Rituximab may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam and Samarium (153Sm) lexidro... |
DB00264 | DB00938 | 88 | 455 | [
"DDInter1200",
"DDInter1635"
] | Metoprolol | Salmeterol | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
88,
24,
455
]
],
[
[
88,
24,
688
],
[
688,
63,
455
]
],
[
[
88,
6,
3576
],
[
3576,
45,
455
]
],
[
[
88,
21,
29024
],
[
29024,
60... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Metoprolol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Salmeterol (Compound)
Metoprolol (Compound... |
DB00432 | DB08904 | 1,083 | 375 | [
"DDInter1868",
"DDInter342"
] | Trifluridine | Certolizumab pegol | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
1083,
25,
375
]
],
[
[
1083,
63,
1461
],
[
1461,
23,
375
]
],
[
[
1083,
40,
231
],
[
231,
24,
375
]
],
[
[
1083,
24,
200
],
[
200,
... | [
[
[
"Trifluridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Trifluridine (Compound) resembles Stavudine (Compound) and Stavudine may cause a moderate interaction that... |
DB00209 | DB00497 | 352 | 828 | [
"DDInter1886",
"DDInter1366"
] | Trospium | Oxycodone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
352,
24,
828
]
],
[
[
352,
24,
421
],
[
421,
1,
828
]
],
[
[
352,
24,
560
],
[
560,
40,
828
]
],
[
[
352,
6,
12523
],
[
12523,
4... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Oxycodone (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Oxymorphone and Oxymorphone (Compound) resembles Oxycodone (Compound... |
DB00005 | DB00601 | 1,057 | 453 | [
"DDInter687",
"DDInter1073"
] | Etanercept | Linezolid | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Major | 2 | [
[
[
1057,
25,
453
]
],
[
[
1057,
24,
792
],
[
792,
1,
453
]
],
[
[
1057,
25,
770
],
[
770,
63,
453
]
],
[
[
1057,
24,
10
],
[
10,
24... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Linezolid"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
],
[
"Rivaroxaba... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaroxaban (Compound) resembles Linezolid (Compound)
Etanercept may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate ... |
DB00420 | DB00553 | 508 | 92 | [
"DDInter1532",
"DDInter1177"
] | Promazine | Methoxsalen | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Moderate | 1 | [
[
[
508,
24,
92
]
],
[
[
508,
6,
8374
],
[
8374,
45,
92
]
],
[
[
508,
7,
3769
],
[
3769,
57,
92
]
],
[
[
508,
1,
146
],
[
146,
63,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxsalen"
]
],
[
[
"Promazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Promazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methoxsalen (Compound)
Promazine (Compound) upregulates EBP (Gene) and EBP (Gene) is downregulated by Methoxsalen (Compound)
Promazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerba... |
DB00261 | DB06822 | 702 | 802 | [
"DDInter93",
"DDInter1812"
] | Anagrelide | Tinzaparin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
702,
25,
802
]
],
[
[
702,
23,
944
],
[
944,
62,
802
]
],
[
[
702,
24,
222
],
[
222,
24,
802
]
],
[
[
702,
25,
758
],
[
758,
24,... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Anagrelide may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine... |
DB01197 | DB11967 | 1,603 | 710 | [
"DDInter292",
"DDInter210"
] | Captopril | Binimetinib | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1603,
24,
710
]
],
[
[
1603,
24,
1220
],
[
1220,
24,
710
]
],
[
[
1603,
63,
1411
],
[
1411,
24,
710
]
],
[
[
1603,
25,
1510
],
[
1510,... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and ... |
DB00580 | DB09054 | 311 | 384 | [
"DDInter1910",
"DDInter905"
] | Valdecoxib | Idelalisib | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
311,
24,
384
]
],
[
[
311,
63,
305
],
[
305,
24,
384
]
],
[
[
311,
24,
891
],
[
891,
24,
384
]
],
[
[
311,
24,
1619
],
[
1619,
6... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia co... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Valdecoxib may cause a moderate interaction that could exacerbate diseases... |
DB00008 | DB09122 | 491 | 1,613 | [
"DDInter1407",
"DDInter1409"
] | Peginterferon alfa-2a | Peginterferon beta-1a | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
491,
24,
1613
]
],
[
[
491,
24,
671
],
[
671,
24,
1613
]
],
[
[
491,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
491,
25,
1011
],
[
1011,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases wh... |
DB00381 | DB08884 | 376 | 796 | [
"DDInter79",
"DDInter800"
] | Amlodipine | Gadoxetic acid | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up ... | Moderate | 1 | [
[
[
376,
24,
796
]
],
[
[
376,
21,
28714
],
[
28714,
60,
796
]
],
[
[
376,
1,
1081
],
[
1081,
24,
796
]
],
[
[
376,
40,
409
],
[
409,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadoxetic acid"
]
],
[
[
"Amlodipine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is ca... | Amlodipine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Gadoxetic acid (Compound)
Amlodipine (Compound) resembles Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Gadoxetic acid
Amlodipine (Compound) resembles Felo... |
DB00261 | DB00861 | 702 | 914 | [
"DDInter93",
"DDInter551"
] | Anagrelide | Diflunisal | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Moderate | 1 | [
[
[
702,
24,
914
]
],
[
[
702,
7,
7483
],
[
7483,
46,
914
]
],
[
[
702,
21,
28828
],
[
28828,
60,
914
]
],
[
[
702,
23,
417
],
[
417,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
]
],
[
[
"Anagrelide",
"{u} (Compound) upregulates {v} (Gene)",
"HLA-DMA"
],
[
"HLA-DMA",
"{u} (Gene) is upregulated by {v... | Anagrelide (Compound) upregulates HLA-DMA (Gene) and HLA-DMA (Gene) is upregulated by Diflunisal (Compound)
Anagrelide (Compound) causes Photosensitivity reaction (Side Effect) and Photosensitivity reaction (Side Effect) is caused by Diflunisal (Compound)
Anagrelide may cause a minor interaction that can limit clinical... |
DB08882 | DB12035 | 1,281 | 943 | [
"DDInter1070",
"DDInter1641"
] | Linagliptin | Sarecycline | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1281,
24,
943
]
],
[
[
1281,
63,
850
],
[
850,
24,
943
]
],
[
[
1281,
24,
971
],
[
971,
63,
943
]
],
[
[
1281,
63,
850
],
[
850,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00651 | DB01215 | 746 | 1,418 | [
"DDInter613",
"DDInter677"
] | Dyphylline | Estazolam | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Minor | 0 | [
[
[
746,
23,
1418
]
],
[
[
746,
62,
523
],
[
523,
1,
1418
]
],
[
[
746,
23,
1216
],
[
1216,
40,
1418
]
],
[
[
746,
62,
905
],
[
905,
... | [
[
[
"Dyphylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Estazolam"
]
],
[
[
"Dyphylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alprazolam"
],
[
"... | Dyphylline may cause a minor interaction that can limit clinical effects when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Dyphylline may cause a minor interaction that can limit clinical effects when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Dyphyl... |
DB00270 | DB08820 | 1,428 | 1,478 | [
"DDInter993",
"DDInter997"
] | Isradipine | Ivacaftor | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1428,
24,
1478
]
],
[
[
1428,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1428,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1428,
24,
617
],
[
61... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Isradipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Isradipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Isradipine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesoni... |
DB01259 | DB09083 | 392 | 880 | [
"DDInter1024",
"DDInter996"
] | Lapatinib | Ivabradine | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
392,
25,
880
]
],
[
[
392,
63,
480
],
[
480,
24,
880
]
],
[
[
392,
24,
1478
],
[
1478,
24,
880
]
],
[
[
392,
24,
159
],
[
159,
6... | [
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol",... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor... |
DB01577 | DB03754 | 1,529 | 1,400 | [
"DDInter1161",
"DDInter1883"
] | Metamfetamine | Tromethamine | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th e... | Moderate | 1 | [
[
[
1529,
24,
1400
]
],
[
[
1529,
63,
959
],
[
959,
23,
1400
]
],
[
[
1529,
40,
93
],
[
93,
24,
1400
]
],
[
[
1529,
74,
1445
],
[
1445,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tromethamine"
]
],
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a minor interaction that can limit clinical effects when taken with Tromethamine
Metamfetamine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine may cause a moderate inte... |
DB00529 | DB00681 | 789 | 1,287 | [
"DDInter779",
"DDInter85"
] | Foscarnet | Amphotericin B | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Major | 2 | [
[
[
789,
25,
1287
]
],
[
[
789,
21,
28841
],
[
28841,
60,
1287
]
],
[
[
789,
63,
600
],
[
600,
23,
1287
]
],
[
[
789,
63,
251
],
[
251,
... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amphotericin B"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Bronchospasm"
],
[
"Bronchospasm",
"{u} (Side Effect) is caused by {... | Foscarnet (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Amphotericin B (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with... |
DB00060 | DB00533 | 912 | 1,416 | [
"DDInter947",
"DDInter1613"
] | Interferon beta-1a | Rofecoxib | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Moderate | 1 | [
[
[
912,
24,
1416
]
],
[
[
912,
24,
1383
],
[
1383,
63,
1416
]
],
[
[
912,
63,
1560
],
[
1560,
24,
1416
]
],
[
[
912,
24,
482
],
[
482,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rofecoxib"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfa... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00570 | DB12332 | 147 | 1,619 | [
"DDInter1936",
"DDInter1626"
] | Vinblastine | Rucaparib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
147,
24,
1619
]
],
[
[
147,
23,
307
],
[
307,
23,
1619
]
],
[
[
147,
24,
112
],
[
112,
23,
1619
]
],
[
[
147,
24,
259
],
[
259,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Vinblastine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Vinblastine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronid... |
DB01064 | DB01396 | 1,148 | 1,482 | [
"DDInter987",
"DDInter553"
] | Isoprenaline | Digitoxin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
1148,
24,
1482
]
],
[
[
1148,
63,
1252
],
[
1252,
1,
1482
]
],
[
[
1148,
7,
2969
],
[
2969,
46,
1482
]
],
[
[
1148,
18,
6461
],
[
6461... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Isoprenaline (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Digitoxin (Compound)
Isoprenaline (Compound) downregulates DDX10 (Gene) and DDX... |
DB08938 | DB09263 | 1,384 | 1,436 | [
"DDInter1112",
"DDInter1399"
] | Magaldrate | Patiromer | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Major | 2 | [
[
[
1384,
25,
1436
]
],
[
[
1384,
62,
1220
],
[
1220,
24,
1436
]
],
[
[
1384,
24,
428
],
[
428,
63,
1436
]
],
[
[
1384,
63,
1152
],
[
1152... | [
[
[
"Magaldrate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Patiromer"
]
],
[
[
"Magaldrate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
[
"Dexamethas... | Magaldrate may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate a... |
DB01276 | DB01365 | 123 | 280 | [
"DDInter706",
"DDInter1151"
] | Exenatide | Mephentermine | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
123,
24,
280
]
],
[
[
123,
63,
1445
],
[
1445,
1,
280
]
],
[
[
123,
24,
1529
],
[
1529,
1,
280
]
],
[
[
123,
24,
22
],
[
22,
40,... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Mephentermine (Compound)
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Mephe... |
DB08875 | DB12141 | 1,618 | 971 | [
"DDInter262",
"DDInter817"
] | Cabozantinib | Gilteritinib | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
1618,
25,
971
]
],
[
[
1618,
23,
1135
],
[
1135,
23,
971
]
],
[
[
1618,
62,
1247
],
[
1247,
23,
971
]
],
[
[
1618,
64,
485
],
[
485,
... | [
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Cabozantinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxeg... | Cabozantinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Cabozantinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Su... |
DB00402 | DB11730 | 1,407 | 351 | [
"DDInter685",
"DDInter1588"
] | Eszopiclone | Ribociclib | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1407,
24,
351
]
],
[
[
1407,
24,
222
],
[
222,
23,
351
]
],
[
[
1407,
24,
283
],
[
283,
62,
351
]
],
[
[
1407,
24,
597
],
[
597,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedr... |
DB09074 | DB14444 | 1,362 | 151 | [
"DDInter1327",
"DDInter924"
] | Olaparib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1362,
24,
151
]
],
[
[
1362,
63,
66
],
[
66,
24,
151
]
],
[
[
1362,
24,
1619
],
[
1619,
24,
151
]
],
[
[
1362,
64,
375
],
[
375,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exace... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Olaparib may cause a moderate interacti... |
DB00668 | DB01253 | 874 | 628 | [
"DDInter652",
"DDInter664"
] | Epinephrine | Ergometrine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Major | 2 | [
[
[
874,
25,
628
]
],
[
[
874,
64,
1131
],
[
1131,
40,
628
]
],
[
[
874,
25,
826
],
[
826,
40,
628
]
],
[
[
874,
6,
5214
],
[
5214,
... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ergometrine"
]
],
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methysergide"
],
[
"Methysergide",
... | Epinephrine may lead to a major life threatening interaction when taken with Methysergide and Methysergide (Compound) resembles Ergometrine (Compound)
Epinephrine may lead to a major life threatening interaction when taken with Ergotamine and Ergotamine (Compound) resembles Ergometrine (Compound)
Epinephrine (Compound)... |
DB06288 | DB06663 | 607 | 1,154 | [
"DDInter77",
"DDInter1398"
] | Amisulpride | Pasireotide | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
607,
25,
1154
]
],
[
[
607,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
607,
62,
112
],
[
112,
23,
1154
]
],
[
[
607,
24,
1662
],
[
1662,
... | [
[
[
"Amisulpride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Amisulpride",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused... | Amisulpride (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Amisulpride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when tak... |
DB00146 | DB00364 | 160 | 417 | [
"DDInter265",
"DDInter1717"
] | Calcifediol | Sucralfate | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protec... | Moderate | 1 | [
[
[
160,
24,
417
]
],
[
[
160,
24,
1072
],
[
1072,
62,
417
]
],
[
[
160,
24,
1482
],
[
1482,
63,
417
]
],
[
[
160,
24,
362
],
[
362,
... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
[
... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin... |
DB12141 | DB12887 | 971 | 1,598 | [
"DDInter817",
"DDInter1750"
] | Gilteritinib | Tazemetostat | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
971,
24,
1598
]
],
[
[
971,
63,
594
],
[
594,
24,
1598
]
],
[
[
971,
64,
985
],
[
985,
24,
1598
]
],
[
[
971,
24,
1476
],
[
1476,
... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
],
... | Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Gilteritinib may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may ... |
DB00581 | DB01211 | 355 | 609 | [
"DDInter1018",
"DDInter393"
] | Lactulose | Clarithromycin | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
355,
24,
609
]
],
[
[
355,
63,
1570
],
[
1570,
24,
609
]
],
[
[
355,
21,
29180
],
[
29180,
60,
609
]
],
[
[
355,
63,
600
],
[
600,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Lactulose (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is ... |
DB08899 | DB09068 | 129 | 1,427 | [
"DDInter649",
"DDInter1948"
] | Enzalutamide | Vortioxetine | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
129,
24,
1427
]
],
[
[
129,
24,
1320
],
[
1320,
63,
1427
]
],
[
[
129,
63,
477
],
[
477,
24,
1427
]
],
[
[
129,
25,
1017
],
[
1017,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilo... |
DB00965 | DB09293 | 1,258 | 116 | [
"DDInter693",
"DDInter954"
] | Ethiodized oil | Iodide I-131 | Ethiodized oil is used by injection as a radio-opaque contrast agent. The composition of the oil is comprised of iodine combined with ethyl esters of fatty acids of poppyseed oil. And although these esters are primarily as ethyl monoiodostearate and ethyl diiodostearate, the actual, specific structure is unknown. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1258,
24,
116
]
],
[
[
1258,
24,
1074
],
[
1074,
63,
516
],
[
516,
24,
116
]
],
[
[
1258,
63,
1648
],
[
1648,
24,
1486
],
[
1486,
24... | [
[
[
"Ethiodized oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Ethiodized oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
... | Ethiodized oil may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with I... |
DB00531 | DB00851 | 450 | 611 | [
"DDInter456",
"DDInter463"
] | Cyclophosphamide | Dacarbazine | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
450,
24,
611
]
],
[
[
450,
23,
739
],
[
739,
62,
611
]
],
[
[
450,
23,
646
],
[
646,
23,
611
]
],
[
[
450,
62,
1176
],
[
1176,
2... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
... | Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Cinoxacin ... |
DB00569 | DB13148 | 553 | 1,566 | [
"DDInter775",
"DDInter422"
] | Fondaparinux | Coagulation factor X human | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. However its use is limited in the perioperative setting for the management of bleeding in major surgery in patients with moderate and severe here... | Moderate | 1 | [
[
[
553,
24,
1566
]
],
[
[
553,
25,
1409
],
[
1409,
24,
1566
]
],
[
[
553,
25,
1409
],
[
1409,
25,
1421
],
[
1421,
24,
1566
]
],
[
[
553,
... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Coagulation factor X human"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[... | Fondaparinux may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Coagulation factor X human
Fondaparinux may lead to a major life threatening interaction when taken with Apixaban and Apixaban may lead to a... |
DB04948 | DB11827 | 1,084 | 433 | [
"DDInter1083",
"DDInter669"
] | Lofexidine | Ertugliflozin | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1084,
24,
433
]
],
[
[
1084,
40,
1020
],
[
1020,
24,
433
]
],
[
[
1084,
63,
521
],
[
521,
24,
433
]
],
[
[
1084,
24,
1455
],
[
1455,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Lofexidine",
"{u} (Compound) resembles {v} (Compound)",
"Clonidine"
],
[
"Clonidine",
"{u} may cause a modera... | Lofexidine (Compound) resembles Clonidine (Compound) and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin may cause a moderate interaction that could ... |
DB00704 | DB09049 | 267 | 1,135 | [
"DDInter1263",
"DDInter1261"
] | Naltrexone | Naloxegol | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Moderate | 1 | [
[
[
267,
24,
1135
]
],
[
[
267,
24,
33
],
[
33,
23,
1135
]
],
[
[
267,
24,
971
],
[
971,
62,
1135
]
],
[
[
267,
63,
888
],
[
888,
23... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteri... |
DB11796 | DB12332 | 1,612 | 1,619 | [
"DDInter786",
"DDInter1626"
] | Fostemsavir | Rucaparib | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1612,
24,
1619
]
],
[
[
1612,
62,
112
],
[
112,
23,
1619
]
],
[
[
1612,
63,
1662
],
[
1662,
24,
1619
]
],
[
[
1612,
24,
823
],
[
823,
... | [
[
[
"Fostemsavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Fostemsavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Fostemsavir may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid ... |
DB06176 | DB08895 | 1,342 | 976 | [
"DDInter1616",
"DDInter1825"
] | Romidepsin | Tofacitinib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1342,
25,
976
]
],
[
[
1342,
63,
1461
],
[
1461,
23,
976
]
],
[
[
1342,
24,
214
],
[
214,
63,
976
]
],
[
[
1342,
25,
982
],
[
982,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostama... |
DB00647 | DB00804 | 675 | 1,507 | [
"DDInter528",
"DDInter543"
] | Dextropropoxyphene | Dicyclomine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
675,
24,
1507
]
],
[
[
675,
21,
29231
],
[
29231,
60,
1507
]
],
[
[
675,
75,
1594
],
[
1594,
24,
1507
]
],
[
[
675,
25,
832
],
[
832,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
... | Dextropropoxyphene (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Dicyclomine (Compound)
Dextropropoxyphene (Compound) resembles Doxylamine (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Doxylamine and Doxylamine may c... |
DB01589 | DB11837 | 481 | 1,297 | [
"DDInter1552",
"DDInter1351"
] | Quazepam | Osilodrostat | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
481,
24,
1297
]
],
[
[
481,
63,
222
],
[
222,
23,
1297
]
],
[
[
481,
63,
401
],
[
401,
24,
1297
]
],
[
[
481,
23,
286
],
[
286,
... | [
[
[
"Quazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Quazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promet... |
DB00500 | DB00927 | 24 | 1,559 | [
"DDInter1831",
"DDInter712"
] | Tolmetin | Famotidine | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Minor | 0 | [
[
[
24,
23,
1559
]
],
[
[
24,
21,
29310
],
[
29310,
60,
1559
]
],
[
[
24,
40,
886
],
[
886,
23,
1559
]
],
[
[
24,
24,
1274
],
[
1274,
... | [
[
[
"Tolmetin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Famotidine"
]
],
[
[
"Tolmetin",
"{u} (Compound) causes {v} (Side Effect)",
"Toxic epidermal necrolysis"
],
[
"Toxic epidermal necrolysis",
... | Tolmetin (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Famotidine (Compound)
Tolmetin (Compound) resembles Ketorolac (Compound) and Ketorolac may cause a minor interaction that can limit clinical effects when taken with Famotidine
Tolmetin may cause... |
DB01211 | DB11827 | 609 | 433 | [
"DDInter393",
"DDInter669"
] | Clarithromycin | Ertugliflozin | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
609,
24,
433
]
],
[
[
609,
24,
1654
],
[
1654,
63,
433
]
],
[
[
609,
63,
695
],
[
695,
24,
433
]
],
[
[
609,
64,
1176
],
[
1176,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan and Somapacitan may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clozapin... |
DB00668 | DB06655 | 874 | 5 | [
"DDInter652",
"DDInter1077"
] | Epinephrine | Liraglutide | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
874,
24,
5
]
],
[
[
874,
63,
1252
],
[
1252,
23,
5
]
],
[
[
874,
63,
245
],
[
245,
24,
5
]
],
[
[
874,
24,
1630
],
[
1630,
24,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepirid... |
DB00688 | DB15091 | 955 | 676 | [
"DDInter1251",
"DDInter1901"
] | Mycophenolate mofetil | Upadacitinib | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
955,
25,
676
]
],
[
[
955,
23,
1193
],
[
1193,
23,
676
]
],
[
[
955,
24,
1430
],
[
1430,
24,
676
]
],
[
[
955,
63,
597
],
[
597,
... | [
[
[
"Mycophenolate mofetil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Mycophenolate mofetil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
... | Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when take... |
DB00279 | DB00284 | 1,152 | 1,647 | [
"DDInter1074",
"DDInter11"
] | Liothyronine | Acarbose | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
1152,
24,
1647
]
],
[
[
1152,
24,
279
],
[
279,
62,
1647
]
],
[
[
1152,
23,
417
],
[
417,
63,
1647
]
],
[
[
1152,
1,
624
],
[
624,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
],
[... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose
Liothyronine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucral... |
DB00377 | DB01236 | 1,494 | 679 | [
"DDInter1382",
"DDInter1664"
] | Palonosetron | Sevoflurane | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Moderate | 1 | [
[
[
1494,
24,
679
]
],
[
[
1494,
24,
1262
],
[
1262,
40,
679
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
679
]
],
[
[
1494,
21,
30319
],
[
30319... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) resembles Sevoflurane (Compound)
Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sevoflurane (Compound)
Palonosetron (Compound) causes Supraventricular extrasystole... |
DB06176 | DB11901 | 1,342 | 913 | [
"DDInter1616",
"DDInter107"
] | Romidepsin | Apalutamide | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1342,
24,
913
]
],
[
[
1342,
62,
112
],
[
112,
23,
913
]
],
[
[
1342,
63,
600
],
[
600,
24,
913
]
],
[
[
1342,
24,
28
],
[
28,
2... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fl... |
DB00808 | DB09268 | 1,605 | 1,662 | [
"DDInter916",
"DDInter1464"
] | Indapamide | Picosulfuric acid | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1605,
24,
1662
]
],
[
[
1605,
24,
708
],
[
708,
24,
1662
]
],
[
[
1605,
63,
1573
],
[
1573,
24,
1662
]
],
[
[
1605,
62,
964
],
[
964,
... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Predniso... |
DB00564 | DB01234 | 1,236 | 1,220 | [
"DDInter293",
"DDInter513"
] | Carbamazepine | Dexamethasone | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1236,
24,
1220
]
],
[
[
1236,
24,
870
],
[
870,
1,
1220
]
],
[
[
1236,
24,
175
],
[
175,
40,
1220
]
],
[
[
1236,
63,
251
],
[
251,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembl... |
DB00682 | DB01095 | 126 | 671 | [
"DDInter1951",
"DDInter769"
] | Warfarin | Fluvastatin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Minor | 0 | [
[
[
126,
23,
671
]
],
[
[
126,
23,
788
],
[
788,
40,
671
]
],
[
[
126,
24,
14
],
[
14,
63,
671
]
],
[
[
126,
6,
7950
],
[
7950,
45,
... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fluvastatin"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pitavastatin"
],
[
"... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Pitavastatin and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that co... |
DB00284 | DB09129 | 1,647 | 625 | [
"DDInter11",
"DDInter373"
] | Acarbose | Chromic chloride | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN). | Moderate | 1 | [
[
[
1647,
24,
625
]
],
[
[
1647,
24,
1021
],
[
1021,
24,
625
]
],
[
[
1647,
23,
1645
],
[
1645,
24,
625
]
],
[
[
1647,
24,
1021
],
[
1021,... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromic chloride"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
],
[... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide and Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Chromic chloride
Acarbose may cause a minor interaction that can limit clinical effects when taken with Metformin and Metfo... |
DB00041 | DB00544 | 1,648 | 970 | [
"DDInter38",
"DDInter757"
] | Aldesleukin | Fluorouracil | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Moderate | 1 | [
[
[
1648,
24,
970
]
],
[
[
1648,
23,
945
],
[
945,
62,
970
]
],
[
[
1648,
25,
147
],
[
147,
62,
970
]
],
[
[
1648,
23,
839
],
[
839,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
],
... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Fluorouracil
Aldesleukin may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may ... |
DB08907 | DB09098 | 1,344 | 98 | [
"DDInter280",
"DDInter1700"
] | Canagliflozin | Somatrem | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1344,
24,
98
]
],
[
[
1344,
63,
168
],
[
168,
23,
98
]
],
[
[
1344,
63,
336
],
[
336,
24,
98
]
],
[
[
1344,
24,
861
],
[
861,
63... | [
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nife... |
DB11901 | DB11995 | 913 | 1,634 | [
"DDInter107",
"DDInter143"
] | Apalutamide | Avatrombopag | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
913,
24,
1634
]
],
[
[
913,
63,
1622
],
[
1622,
24,
1634
]
],
[
[
913,
64,
760
],
[
760,
24,
1634
]
],
[
[
913,
25,
971
],
[
971,
... | [
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Apalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
],
... | Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Apalutamide may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat ma... |
DB00010 | DB09564 | 1,649 | 1,296 | [
"DDInter1661",
"DDInter930"
] | Sermorelin | Insulin degludec | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1649,
24,
1296
]
],
[
[
1649,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1649,
24,
1385
],
[
1385,
63,
1296
]
],
[
[
1649,
24,
1411
],
[
14... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide a... |
DB01177 | DB04855 | 77 | 540 | [
"DDInter904",
"DDInter602"
] | Idarubicin | Dronedarone | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
77,
25,
540
]
],
[
[
77,
64,
347
],
[
347,
40,
540
]
],
[
[
77,
6,
12523
],
[
12523,
45,
540
]
],
[
[
77,
21,
28883
],
[
28883,
... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (C... | Idarubicin may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Idarubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dronedarone (Compound)
Idarubicin (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side ... |
DB00381 | DB00687 | 376 | 870 | [
"DDInter79",
"DDInter747"
] | Amlodipine | Fludrocortisone | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
376,
24,
870
]
],
[
[
376,
24,
1220
],
[
1220,
40,
870
]
],
[
[
376,
21,
28835
],
[
28835,
60,
870
]
],
[
[
376,
24,
1040
],
[
1040,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Amlodipine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Fludrocortisone (Compound)
Amlodipine may cau... |
DB00261 | DB00316 | 702 | 474 | [
"DDInter93",
"DDInter14"
] | Anagrelide | Acetaminophen | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Moderate | 1 | [
[
[
702,
24,
474
]
],
[
[
702,
6,
7950
],
[
7950,
45,
474
]
],
[
[
702,
18,
2672
],
[
2672,
57,
474
]
],
[
[
702,
21,
28792
],
[
28792,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetaminophen"
]
],
[
[
"Anagrelide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound... | Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Acetaminophen (Compound)
Anagrelide (Compound) downregulates NR2F6 (Gene) and NR2F6 (Gene) is downregulated by Acetaminophen (Compound)
Anagrelide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect)... |
DB11730 | DB12001 | 351 | 564 | [
"DDInter1588",
"DDInter7"
] | Ribociclib | Abemaciclib | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
351,
24,
564
]
],
[
[
351,
63,
536
],
[
536,
24,
564
]
],
[
[
351,
64,
868
],
[
868,
24,
564
]
],
[
[
351,
25,
982
],
[
982,
63,... | [
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Ribociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
[... | Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Ribociclib may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may... |
DB00454 | DB11817 | 1,349 | 1,259 | [
"DDInter1150",
"DDInter165"
] | Meperidine | Baricitinib | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
1349,
24,
1259
]
],
[
[
1349,
40,
411
],
[
411,
24,
1259
]
],
[
[
1349,
24,
407
],
[
407,
24,
1259
]
],
[
[
1349,
64,
475
],
[
475,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Meperidine",
"{u} (Compound) resembles {v} (Compound)",
"Remifentanil"
],
[
"Remifentanil",
"{u} may cause a mo... | Meperidine (Compound) resembles Remifentanil (Compound) and Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exac... |
DB04855 | DB08880 | 540 | 1,510 | [
"DDInter602",
"DDInter1771"
] | Dronedarone | Teriflunomide | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
540,
25,
1510
]
],
[
[
540,
63,
608
],
[
608,
23,
1510
]
],
[
[
540,
25,
129
],
[
129,
63,
1510
]
],
[
[
540,
63,
303
],
[
303,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidoca... | Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Dronedarone may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may c... |
DB00334 | DB04843 | 867 | 1,511 | [
"DDInter1326",
"DDInter1149"
] | Olanzapine | Mepenzolate | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
867,
24,
1511
]
],
[
[
867,
24,
537
],
[
537,
24,
1511
]
],
[
[
867,
63,
352
],
[
352,
24,
1511
]
],
[
[
867,
24,
649
],
[
649,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium ... |
DB00418 | DB00486 | 536 | 1,614 | [
"DDInter1650",
"DDInter1253"
] | Secobarbital | Nabilone | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
536,
24,
1614
]
],
[
[
536,
24,
530
],
[
530,
1,
1614
]
],
[
[
536,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
536,
63,
999
],
[
999,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Secobarbital (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Secobarbital may cau... |
DB00889 | DB09082 | 1,133 | 659 | [
"DDInter840",
"DDInter1934"
] | Granisetron | Vilanterol | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1133,
24,
659
]
],
[
[
1133,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1133,
24,
927
],
[
927,
63,
659
]
],
[
[
1133,
25,
1069
],
[
1069,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and... |
DB01254 | DB09030 | 1,213 | 840 | [
"DDInter484",
"DDInter1945"
] | Dasatinib | Vorapaxar | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
1213,
25,
840
]
],
[
[
1213,
23,
944
],
[
944,
62,
840
]
],
[
[
1213,
24,
765
],
[
765,
24,
840
]
],
[
[
1213,
63,
383
],
[
383,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a mo... |
DB06616 | DB11757 | 594 | 960 | [
"DDInter224",
"DDInter994"
] | Bosutinib | Istradefylline | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
594,
24,
960
]
],
[
[
594,
63,
86
],
[
86,
24,
960
]
],
[
[
594,
64,
1419
],
[
1419,
24,
960
]
],
[
[
594,
24,
971
],
[
971,
63,... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Istradefylline
Bosutinib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a ... |
DB00938 | DB00978 | 455 | 739 | [
"DDInter1635",
"DDInter1084"
] | Salmeterol | Lomefloxacin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
455,
24,
739
]
],
[
[
455,
24,
945
],
[
945,
40,
739
]
],
[
[
455,
63,
1176
],
[
1176,
1,
739
]
],
[
[
455,
18,
3199
],
[
3199,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
],
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin... |
DB00604 | DB00726 | 1,425 | 1,164 | [
"DDInter385",
"DDInter1876"
] | Cisapride | Trimipramine | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Major | 2 | [
[
[
1425,
25,
1164
]
],
[
[
1425,
25,
1237
],
[
1237,
40,
1164
]
],
[
[
1425,
64,
576
],
[
576,
40,
1164
]
],
[
[
1425,
24,
1335
],
[
1335... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
],
[
"Clomipramine",
"{... | Cisapride may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Cisapride may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) resembles Trimipramine (Compound)
Cisapride may cause a mode... |
DB00277 | DB01174 | 1,031 | 697 | [
"DDInter1791",
"DDInter1442"
] | Theophylline | Phenobarbital | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1031,
24,
697
]
],
[
[
1031,
24,
759
],
[
759,
1,
697
]
],
[
[
1031,
63,
362
],
[
362,
1,
697
]
],
[
[
1031,
24,
536
],
[
536,
4... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Comp... |
DB00312 | DB01105 | 1,023 | 222 | [
"DDInter1423",
"DDInter1665"
] | Pentobarbital | Sibutramine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1023,
24,
222
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
222
]
],
[
[
1023,
21,
28758
],
[
28758,
60,
222
]
],
[
[
1023,
24,
384
],
[
384,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Pentobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Pentobarbital (Compound) causes Hyperkinesia (Side Effect) and Hyperkinesia (Side Effect) is caused by Sibutramine (Compound)
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Id... |
DB01592 | DB06824 | 1,596 | 29 | [
"DDInter975",
"DDInter1864"
] | Iron | Triethylenetetramine | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved... | Moderate | 1 | [
[
[
1596,
24,
29
]
],
[
[
1596,
23,
1193
],
[
1193,
62,
29
]
],
[
[
1596,
63,
1283
],
[
1283,
24,
29
]
],
[
[
1596,
24,
286
],
[
286,
... | [
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triethylenetetramine"
]
],
[
[
"Iron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Iron may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Triethylenetetramine
Iron may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and... |
DB00353 | DB08899 | 588 | 129 | [
"DDInter1187",
"DDInter649"
] | Methylergometrine | Enzalutamide | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
588,
24,
129
]
],
[
[
588,
24,
918
],
[
918,
1,
129
]
],
[
[
588,
6,
8374
],
[
8374,
45,
129
]
],
[
[
588,
21,
28921
],
[
28921,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamid... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Methylergometrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Methylergometrine (Compound) causes Dizzines... |
DB04865 | DB09052 | 4 | 250 | [
"DDInter1335",
"DDInter220"
] | Omacetaxine mepesuccinate | Blinatumomab | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
4,
24,
250
]
],
[
[
4,
24,
949
],
[
949,
63,
250
]
],
[
[
4,
24,
637
],
[
637,
24,
250
]
],
[
[
4,
63,
305
],
[
305,
24,
2... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Blinatum... |
DB08826 | DB08938 | 1,292 | 1,384 | [
"DDInter489",
"DDInter1112"
] | Deferiprone | Magaldrate | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1292,
24,
1384
]
],
[
[
1292,
64,
60
],
[
60,
23,
1384
]
],
[
[
1292,
25,
1468
],
[
1468,
23,
1384
]
],
[
[
1292,
25,
405
],
[
405,
... | [
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Capecitabine"
],
[
"Capeci... | Deferiprone may lead to a major life threatening interaction when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Deferiprone may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a minor inter... |
DB00526 | DB01159 | 1,555 | 419 | [
"DDInter1355",
"DDInter854"
] | Oxaliplatin | Halothane | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
1555,
24,
419
]
],
[
[
1555,
6,
6365
],
[
6365,
45,
419
]
],
[
[
1555,
24,
112
],
[
112,
23,
419
]
],
[
[
1555,
24,
629
],
[
629,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)"... | Oxaliplatin (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Halothane (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Halothane
Oxaliplatin ma... |
DB00352 | DB01045 | 482 | 463 | [
"DDInter1814",
"DDInter1590"
] | Tioguanine | Rifampicin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
482,
24,
463
]
],
[
[
482,
63,
1101
],
[
1101,
23,
463
]
],
[
[
482,
24,
1228
],
[
1228,
62,
463
]
],
[
[
482,
24,
1387
],
[
1387,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Rifampicin
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib and Lenvatin... |
DB01157 | DB14711 | 304 | 779 | [
"DDInter1875",
"DDInter1680"
] | Trimetrexate | Smallpox (Vaccinia) Vaccine, Live | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
304,
25,
779
]
],
[
[
304,
64,
1064
],
[
1064,
25,
779
]
],
[
[
304,
63,
1560
],
[
1560,
25,
779
]
],
[
[
304,
25,
1259
],
[
1259,
... | [
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Trimetrexate may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspa... |
DB00252 | DB14723 | 362 | 159 | [
"DDInter1460",
"DDInter1026"
] | Phenytoin | Larotrectinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
362,
25,
159
]
],
[
[
362,
24,
222
],
[
222,
23,
159
]
],
[
[
362,
25,
466
],
[
466,
23,
159
]
],
[
[
362,
25,
741
],
[
741,
24,... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutram... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Phenytoin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may c... |
DB01263 | DB09079 | 859 | 1,496 | [
"DDInter1494",
"DDInter1296"
] | Posaconazole | Nintedanib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
859,
24,
1496
]
],
[
[
859,
24,
741
],
[
741,
63,
1496
]
],
[
[
859,
63,
609
],
[
609,
24,
1496
]
],
[
[
859,
64,
477
],
[
477,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin an... |
DB00059 | DB00982 | 1,560 | 1,517 | [
"DDInter1404",
"DDInter991"
] | Pegaspargase | Isotretinoin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
1560,
24,
1517
]
],
[
[
1560,
24,
640
],
[
640,
25,
1517
]
],
[
[
1560,
24,
362
],
[
362,
24,
1517
]
],
[
[
1560,
24,
868
],
[
868,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acitretin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may caus... |
DB00738 | DB01267 | 485 | 519 | [
"DDInter1420",
"DDInter1381"
] | Pentamidine | Paliperidone | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
485,
24,
519
]
],
[
[
485,
63,
1664
],
[
1664,
1,
519
]
],
[
[
485,
25,
924
],
[
924,
1,
519
]
],
[
[
485,
6,
7524
],
[
7524,
45... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Pentamidine may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Compound)
Penta... |
DB00612 | DB01143 | 1,121 | 923 | [
"DDInter216",
"DDInter65"
] | Bisoprolol | Amifostine | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1121,
24,
923
]
],
[
[
1121,
21,
28642
],
[
28642,
60,
923
]
],
[
[
1121,
1,
819
],
[
819,
63,
923
]
],
[
[
1121,
1,
887
],
[
887,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Bisoprolol",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v... | Bisoprolol (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Bisoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Bisoprolol (Compound) resembles Pindolol (Compound) ... |
DB00023 | DB06081 | 305 | 1,046 | [
"DDInter127",
"DDInter286"
] | Asparaginase Escherichia coli | Caplacizumab | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Moderate | 1 | [
[
[
305,
24,
1046
]
],
[
[
305,
24,
1171
],
[
1171,
24,
1046
]
],
[
[
305,
24,
1496
],
[
1496,
63,
1046
]
],
[
[
305,
24,
1479
],
[
1479,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caplacizumab"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases... |
DB01001 | DB01211 | 688 | 609 | [
"DDInter1632",
"DDInter393"
] | Salbutamol | Clarithromycin | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
688,
24,
609
]
],
[
[
688,
63,
1570
],
[
1570,
24,
609
]
],
[
[
688,
6,
8374
],
[
8374,
45,
609
]
],
[
[
688,
21,
28759
],
[
28759,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Salbut... |
DB00445 | DB11828 | 322 | 1,406 | [
"DDInter655",
"DDInter1281"
] | Epirubicin | Neratinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
322,
24,
1406
]
],
[
[
322,
24,
392
],
[
392,
24,
1406
]
],
[
[
322,
25,
1510
],
[
1510,
24,
1406
]
],
[
[
322,
24,
710
],
[
710,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Epirubicin may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cau... |
DB01229 | DB06168 | 973 | 1,531 | [
"DDInter1378",
"DDInter281"
] | Paclitaxel (protein-bound) | Canakinumab | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
973,
24,
1531
]
],
[
[
973,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
973,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
973,
24,
1213
],
[
1213,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Paclitaxel m... |
DB00366 | DB00962 | 1,594 | 1,639 | [
"DDInter600",
"DDInter1957"
] | Doxylamine | Zaleplon | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Moderate | 1 | [
[
[
1594,
24,
1639
]
],
[
[
1594,
21,
29316
],
[
29316,
60,
1639
]
],
[
[
1594,
24,
13
],
[
13,
24,
1639
]
],
[
[
1594,
24,
1609
],
[
1609... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zaleplon"
]
],
[
[
"Doxylamine",
"{u} (Compound) causes {v} (Side Effect)",
"Sweating"
],
[
"Sweating",
"{u} (Side Effect) is caused b... | Doxylamine (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Zaleplon (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Zal... |
DB08899 | DB09118 | 129 | 1,580 | [
"DDInter649",
"DDInter1711"
] | Enzalutamide | Stiripentol | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Major | 2 | [
[
[
129,
25,
1580
]
],
[
[
129,
25,
466
],
[
466,
62,
1580
]
],
[
[
129,
64,
1409
],
[
1409,
24,
1580
]
],
[
[
129,
25,
283
],
[
283,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stiripentol"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamide",
... | Enzalutamide may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Enzalutamide may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate i... |
DB00539 | DB01041 | 11 | 770 | [
"DDInter1837",
"DDInter1789"
] | Toremifene | Thalidomide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
11,
25,
770
]
],
[
[
11,
64,
1668
],
[
1668,
1,
770
]
],
[
[
11,
6,
9842
],
[
9842,
45,
770
]
],
[
[
11,
7,
7669
],
[
7669,
46,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenalidomide"
],
[
"Lenalidomide",
"... | Toremifene may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Toremifene (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Thalidomide (Compound)
Toremifene (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregula... |
DB00543 | DB11730 | 87 | 351 | [
"DDInter82",
"DDInter1588"
] | Amoxapine | Ribociclib | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
87,
25,
351
]
],
[
[
87,
23,
112
],
[
112,
23,
351
]
],
[
[
87,
25,
222
],
[
222,
23,
351
]
],
[
[
87,
24,
283
],
[
283,
62,
... | [
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Amoxapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Amoxapine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may caus... |
DB00900 | DB09122 | 45 | 1,613 | [
"DDInter544",
"DDInter1409"
] | Didanosine | Peginterferon beta-1a | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
45,
24,
1613
]
],
[
[
45,
63,
168
],
[
168,
24,
1613
]
],
[
[
45,
24,
980
],
[
980,
24,
1613
]
],
[
[
45,
24,
1480
],
[
1480,
63... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
... | Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizuma... |
DB00652 | DB01246 | 234 | 820 | [
"DDInter1421",
"DDInter45"
] | Pentazocine | Alimemazine | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
234,
24,
820
]
],
[
[
234,
24,
104
],
[
104,
40,
820
]
],
[
[
234,
24,
401
],
[
401,
24,
820
]
],
[
[
234,
24,
649
],
[
649,
1,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction... |
DB01601 | DB06699 | 833 | 774 | [
"DDInter1089",
"DDInter493"
] | Lopinavir | Degarelix | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
833,
24,
774
]
],
[
[
833,
63,
521
],
[
521,
1,
774
]
],
[
[
833,
63,
480
],
[
480,
24,
774
]
],
[
[
833,
24,
36
],
[
36,
63,
... | [
[
[
"Lopinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Lopinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Lopinavir may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Lopinavir may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exac... |
DB12332 | DB13074 | 1,619 | 877 | [
"DDInter1626",
"DDInter1110"
] | Rucaparib | Macimorelin | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1619,
25,
877
]
],
[
[
1619,
62,
112
],
[
112,
23,
877
]
],
[
[
1619,
63,
1247
],
[
1247,
23,
877
]
],
[
[
1619,
63,
651
],
[
651,
... | [
[
[
"Rucaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Rucaparib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Rucaparib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and... |
DB00604 | DB01110 | 1,425 | 86 | [
"DDInter385",
"DDInter1209"
] | Cisapride | Miconazole | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
1425,
24,
86
]
],
[
[
1425,
6,
8717
],
[
8717,
45,
86
]
],
[
[
1425,
18,
2976
],
[
2976,
57,
86
]
],
[
[
1425,
25,
318
],
[
318,
... | [
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Cisapride",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",
... | Cisapride (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Miconazole (Compound)
Cisapride (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Miconazole (Compound)
Cisapride may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a min... |
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